                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       Universit Paris-Est Crteil Val de Marne
 
<120>  IMMUNOMODULATORY METHODS USING NOTCH AGONISTS

<130>  BET 13P0983

<150>  EP 12305521.2
<151>  2012-05-10

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  2556
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (891)..(891)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Arg Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Pro Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Met Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg Leu Arg Gly Thr Cys Gln Asp Pro Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ser Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Ile Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Lys Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Ala Gly Ala Lys Gly 
    850                 855                 860                 


Gln Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg 
865                 870                 875                 880 


His Gly Ala Ser Cys Gln Asn Thr His Gly Xaa Tyr Arg Cys His Cys 
                885                 890                 895     


Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys 
            900                 905                 910         


Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn 
        915                 920                 925             


Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu 
    930                 935                 940                 


Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn 
945                 950                 955                 960 


Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe 
                965                 970                 975     


Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser 
            980                 985                 990         


Cys Phe Asn Gly Gly Thr Cys Val  Asp Gly Ile Asn Ser  Phe Thr Cys 
        995                 1000                 1005             


Leu Cys  Pro Pro Gly Phe Thr  Gly Ser Tyr Cys Gln  His Val Val 
    1010                 1015                 1020             


Asn Glu  Cys Asp Ser Arg Pro  Cys Leu Leu Gly Gly  Thr Cys Gln 
    1025                 1030                 1035             


Asp Gly  Arg Gly Leu His Arg  Cys Thr Cys Pro Gln  Gly Tyr Thr 
    1040                 1045                 1050             


Gly Pro  Asn Cys Gln Asn Leu  Val His Trp Cys Asp  Ser Ser Pro 
    1055                 1060                 1065             


Cys Lys  Asn Gly Gly Lys Cys  Trp Gln Thr His Thr  Gln Tyr Arg 
    1070                 1075                 1080             


Cys Glu  Cys Pro Ser Gly Trp  Thr Gly Leu Tyr Cys  Asp Val Pro 
    1085                 1090                 1095             


Ser Val  Ser Cys Glu Val Ala  Ala Gln Arg Gln Gly  Val Asp Val 
    1100                 1105                 1110             


Ala Arg  Leu Cys Gln His Gly  Gly Leu Cys Val Asp  Ala Gly Asn 
    1115                 1120                 1125             


Thr His  His Cys Arg Cys Gln  Ala Gly Tyr Thr Gly  Ser Tyr Cys 
    1130                 1135                 1140             


Glu Asp  Leu Val Asp Glu Cys  Ser Pro Ser Pro Cys  Gln Asn Gly 
    1145                 1150                 1155             


Ala Thr  Cys Thr Asp Tyr Leu  Gly Gly Tyr Ser Cys  Lys Cys Val 
    1160                 1165                 1170             


Ala Gly  Tyr His Gly Val Asn  Cys Ser Glu Glu Ile  Asp Glu Cys 
    1175                 1180                 1185             


Leu Ser  His Pro Cys Gln Asn  Gly Gly Thr Cys Leu  Asp Leu Pro 
    1190                 1195                 1200             


Asn Thr  Tyr Lys Cys Ser Cys  Pro Arg Gly Thr Gln  Gly Val His 
    1205                 1210                 1215             


Cys Glu  Ile Asn Val Asp Asp  Cys Asn Pro Pro Val  Asp Pro Val 
    1220                 1225                 1230             


Ser Arg  Ser Pro Lys Cys Phe  Asn Asn Gly Thr Cys  Val Asp Gln 
    1235                 1240                 1245             


Val Gly  Gly Tyr Ser Cys Thr  Cys Pro Pro Gly Phe  Val Gly Glu 
    1250                 1255                 1260             


Arg Cys  Glu Gly Asp Val Asn  Glu Cys Leu Ser Asn  Pro Cys Asp 
    1265                 1270                 1275             


Ala Arg  Gly Thr Gln Asn Cys  Val Gln Arg Val Asn  Asp Phe His 
    1280                 1285                 1290             


Cys Glu  Cys Arg Ala Gly His  Thr Gly Arg Arg Cys  Glu Ser Val 
    1295                 1300                 1305             


Ile Asn  Gly Cys Lys Gly Lys  Pro Cys Lys Asn Gly  Gly Thr Cys 
    1310                 1315                 1320             


Ala Val  Ala Ser Asn Thr Ala  Arg Gly Phe Ile Cys  Lys Cys Pro 
    1325                 1330                 1335             


Ala Gly  Phe Glu Gly Ala Thr  Cys Glu Asn Asp Ala  Arg Thr Cys 
    1340                 1345                 1350             


Gly Ser  Leu Arg Cys Leu Asn  Gly Gly Thr Cys Ile  Ser Gly Pro 
    1355                 1360                 1365             


Arg Ser  Pro Thr Cys Leu Cys  Leu Gly Pro Phe Thr  Gly Pro Glu 
    1370                 1375                 1380             


Cys Gln  Phe Pro Ala Ser Ser  Pro Cys Leu Gly Gly  Asn Pro Cys 
    1385                 1390                 1395             


Tyr Asn  Gln Gly Thr Cys Glu  Pro Thr Ser Glu Ser  Pro Phe Tyr 
    1400                 1405                 1410             


Arg Cys  Leu Cys Pro Ala Lys  Phe Asn Gly Leu Leu  Cys His Ile 
    1415                 1420                 1425             


Leu Asp  Tyr Ser Phe Gly Gly  Gly Ala Gly Arg Asp  Ile Pro Pro 
    1430                 1435                 1440             


Pro Leu  Ile Glu Glu Ala Cys  Glu Leu Pro Glu Cys  Gln Glu Asp 
    1445                 1450                 1455             


Ala Gly  Asn Lys Val Cys Ser  Leu Gln Cys Asn Asn  His Ala Cys 
    1460                 1465                 1470             


Gly Trp  Asp Gly Gly Asp Cys  Ser Leu Asn Phe Asn  Asp Pro Trp 
    1475                 1480                 1485             


Lys Asn  Cys Thr Gln Ser Leu  Gln Cys Trp Lys Tyr  Phe Ser Asp 
    1490                 1495                 1500             


Gly His  Cys Asp Ser Gln Cys  Asn Ser Ala Gly Cys  Leu Phe Asp 
    1505                 1510                 1515             


Gly Phe  Asp Cys Gln Arg Ala  Glu Gly Gln Cys Asn  Pro Leu Tyr 
    1520                 1525                 1530             


Asp Gln  Tyr Cys Lys Asp His  Phe Ser Asp Gly His  Cys Asp Gln 
    1535                 1540                 1545             


Gly Cys  Asn Ser Ala Glu Cys  Glu Trp Asp Gly Leu  Asp Cys Ala 
    1550                 1555                 1560             


Glu His  Val Pro Glu Arg Leu  Ala Ala Gly Thr Leu  Val Val Val 
    1565                 1570                 1575             


Val Leu  Met Pro Pro Glu Gln  Leu Arg Asn Ser Ser  Phe His Phe 
    1580                 1585                 1590             


Leu Arg  Glu Leu Ser Arg Val  Leu His Thr Asn Val  Val Phe Lys 
    1595                 1600                 1605             


Arg Asp  Ala His Gly Gln Gln  Met Ile Phe Pro Tyr  Tyr Gly Arg 
    1610                 1615                 1620             


Glu Glu  Glu Leu Arg Lys His  Pro Ile Lys Arg Ala  Ala Glu Gly 
    1625                 1630                 1635             


Trp Ala  Ala Pro Asp Ala Leu  Leu Gly Gln Val Lys  Ala Ser Leu 
    1640                 1645                 1650             


Leu Pro  Gly Gly Ser Glu Gly  Gly Arg Arg Arg Arg  Glu Leu Asp 
    1655                 1660                 1665             


Pro Met  Asp Val Arg Gly Ser  Ile Val Tyr Leu Glu  Ile Asp Asn 
    1670                 1675                 1680             


Arg Gln  Cys Val Gln Ala Ser  Ser Gln Cys Phe Gln  Ser Ala Thr 
    1685                 1690                 1695             


Asp Val  Ala Ala Phe Leu Gly  Ala Leu Ala Ser Leu  Gly Ser Leu 
    1700                 1705                 1710             


Asn Ile  Pro Tyr Lys Ile Glu  Ala Val Gln Ser Glu  Thr Val Glu 
    1715                 1720                 1725             


Pro Pro  Pro Pro Ala Gln Leu  His Phe Met Tyr Val  Ala Ala Ala 
    1730                 1735                 1740             


Ala Phe  Val Leu Leu Phe Phe  Val Gly Cys Gly Val  Leu Leu Ser 
    1745                 1750                 1755             


Arg Lys  Arg Arg Arg Gln His  Gly Gln Leu Trp Phe  Pro Glu Gly 
    1760                 1765                 1770             


Phe Lys  Val Ser Glu Ala Ser  Lys Lys Lys Arg Arg  Glu Pro Leu 
    1775                 1780                 1785             


Gly Glu  Asp Ser Val Gly Leu  Lys Pro Leu Lys Asn  Ala Ser Asp 
    1790                 1795                 1800             


Gly Ala  Leu Met Asp Asp Asn  Gln Asn Glu Trp Gly  Asp Glu Asp 
    1805                 1810                 1815             


Leu Glu  Thr Lys Lys Phe Arg  Phe Glu Glu Pro Val  Val Leu Pro 
    1820                 1825                 1830             


Asp Leu  Asp Asp Gln Thr Asp  His Arg Gln Trp Thr  Gln Gln His 
    1835                 1840                 1845             


Leu Asp  Ala Ala Asp Leu Arg  Met Ser Ala Met Ala  Pro Thr Pro 
    1850                 1855                 1860             


Pro Gln  Gly Glu Val Asp Ala  Asp Cys Met Asp Val  Asn Val Arg 
    1865                 1870                 1875             


Gly Pro  Asp Gly Phe Thr Pro  Leu Met Ile Ala Ser  Cys Ser Gly 
    1880                 1885                 1890             


Gly Gly  Leu Glu Thr Gly Asn  Ser Glu Glu Glu Glu  Asp Ala Pro 
    1895                 1900                 1905             


Ala Val  Ile Ser Asp Phe Ile  Tyr Gln Gly Ala Ser  Leu His Asn 
    1910                 1915                 1920             


Gln Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1925                 1930                 1935             


Tyr Ser  Arg Ser Asp Ala Ala  Lys Arg Leu Leu Glu  Ala Ser Ala 
    1940                 1945                 1950             


Asp Ala  Asn Ile Gln Asp Asn  Met Gly Arg Thr Pro  Leu His Ala 
    1955                 1960                 1965             


Ala Val  Ser Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1970                 1975                 1980             


Asn Arg  Ala Thr Asp Leu Asp  Ala Arg Met His Asp  Gly Thr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Leu Glu 
    2000                 2005                 2010             


Asp Leu  Ile Asn Ser His Ala  Asp Val Asn Ala Val  Asp Asp Leu 
    2015                 2020                 2025             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Asp 
    2030                 2035                 2040             


Ala Ala  Val Val Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    2045                 2050                 2055             


Asn Asn  Arg Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    2060                 2065                 2070             


Ser Tyr  Glu Thr Ala Lys Val  Leu Leu Asp His Phe  Ala Asn Arg 
    2075                 2080                 2085             


Asp Ile  Thr Asp His Met Asp  Arg Leu Pro Arg Asp  Ile Ala Gln 
    2090                 2095                 2100             


Glu Arg  Met His His Asp Ile  Val Arg Leu Leu Asp  Glu Tyr Asn 
    2105                 2110                 2115             


Leu Val  Arg Ser Pro Gln Leu  His Gly Ala Pro Leu  Gly Gly Thr 
    2120                 2125                 2130             


Pro Thr  Leu Ser Pro Pro Leu  Cys Ser Pro Asn Gly  Tyr Leu Gly 
    2135                 2140                 2145             


Ser Leu  Lys Pro Gly Val Gln  Gly Lys Lys Val Arg  Lys Pro Ser 
    2150                 2155                 2160             


Ser Lys  Gly Leu Ala Cys Gly  Ser Lys Glu Ala Lys  Asp Leu Lys 
    2165                 2170                 2175             


Ala Arg  Arg Lys Lys Ser Gln  Asp Gly Lys Gly Cys  Leu Leu Asp 
    2180                 2185                 2190             


Ser Ser  Gly Met Leu Ser Pro  Val Asp Ser Leu Glu  Ser Pro His 
    2195                 2200                 2205             


Gly Tyr  Leu Ser Asp Val Ala  Ser Pro Pro Leu Leu  Pro Ser Pro 
    2210                 2215                 2220             


Phe Gln  Gln Ser Pro Ser Val  Pro Leu Asn His Leu  Pro Gly Met 
    2225                 2230                 2235             


Pro Asp  Thr His Leu Gly Ile  Gly His Leu Asn Val  Ala Ala Lys 
    2240                 2245                 2250             


Pro Glu  Met Ala Ala Leu Gly  Gly Gly Gly Arg Leu  Ala Phe Glu 
    2255                 2260                 2265             


Thr Gly  Pro Pro Arg Leu Ser  His Leu Pro Val Ala  Ser Gly Thr 
    2270                 2275                 2280             


Ser Thr  Val Leu Gly Ser Ser  Ser Gly Gly Ala Leu  Asn Phe Thr 
    2285                 2290                 2295             


Val Gly  Gly Ser Thr Ser Leu  Asn Gly Gln Cys Glu  Trp Leu Ser 
    2300                 2305                 2310             


Arg Leu  Gln Ser Gly Met Val  Pro Asn Gln Tyr Asn  Pro Leu Arg 
    2315                 2320                 2325             


Gly Ser  Val Ala Pro Gly Pro  Leu Ser Thr Gln Ala  Pro Ser Leu 
    2330                 2335                 2340             


Gln His  Gly Met Val Gly Pro  Leu His Ser Ser Leu  Ala Ala Ser 
    2345                 2350                 2355             


Ala Leu  Ser Gln Met Met Ser  Tyr Gln Gly Leu Pro  Ser Thr Arg 
    2360                 2365                 2370             


Leu Ala  Thr Gln Pro His Leu  Val Gln Thr Gln Gln  Val Gln Pro 
    2375                 2380                 2385             


Gln Asn  Leu Gln Met Gln Gln  Gln Asn Leu Gln Pro  Ala Asn Ile 
    2390                 2395                 2400             


Gln Gln  Gln Gln Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Gln Pro 
    2405                 2410                 2415             


His Leu  Gly Val Ser Ser Ala  Ala Ser Gly His Leu  Gly Arg Ser 
    2420                 2425                 2430             


Phe Leu  Ser Gly Glu Pro Ser  Gln Ala Asp Val Gln  Pro Leu Gly 
    2435                 2440                 2445             


Pro Ser  Ser Leu Ala Val His  Thr Ile Leu Pro Gln  Glu Ser Pro 
    2450                 2455                 2460             


Ala Leu  Pro Thr Ser Leu Pro  Ser Ser Leu Val Pro  Pro Val Thr 
    2465                 2470                 2475             


Ala Ala  Gln Phe Leu Thr Pro  Pro Ser Gln His Ser  Tyr Ser Ser 
    2480                 2485                 2490             


Pro Val  Asp Asn Thr Pro Ser  His Gln Leu Gln Val  Pro Glu His 
    2495                 2500                 2505             


Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro Asp Gln  Trp Ser Ser 
    2510                 2515                 2520             


Ser Ser  Pro His Ser Asn Val  Ser Asp Trp Ser Glu  Gly Val Ser 
    2525                 2530                 2535             


Ser Pro  Pro Thr Ser Met Gln  Ser Gln Ile Ala Arg  Ile Pro Glu 
    2540                 2545                 2550             


Ala Phe  Lys 
    2555     


<210>  2
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asn Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  3
<211>  2281
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Pro Cys Leu Asp Gly Ser Pro Cys Ala Asn Gly Gly Arg Cys Thr 
1               5                   10                  15      


Gln Leu Pro Ser Arg Glu Ala Ala Cys Leu Cys Pro Pro Gly Trp Val 
            20                  25                  30          


Gly Glu Arg Cys Gln Leu Glu Asp Pro Cys His Ser Gly Pro Cys Ala 
        35                  40                  45              


Gly Arg Gly Val Cys Gln Ser Ser Val Val Ala Gly Thr Ala Arg Phe 
    50                  55                  60                  


Ser Cys Arg Cys Pro Arg Gly Phe Arg Gly Pro Asp Cys Ser Leu Pro 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Ser Pro Cys Ala His Gly Ala Arg Cys Ser Val 
                85                  90                  95      


Gly Pro Asp Gly Arg Phe Leu Cys Ser Cys Pro Pro Gly Tyr Gln Gly 
            100                 105                 110         


Arg Ser Cys Arg Ser Asp Val Asp Glu Cys Arg Val Gly Glu Pro Cys 
        115                 120                 125             


Arg His Gly Gly Thr Cys Leu Asn Thr Pro Gly Ser Phe Arg Cys Gln 
    130                 135                 140                 


Cys Pro Ala Gly Tyr Thr Gly Pro Leu Cys Glu Asn Pro Ala Val Pro 
145                 150                 155                 160 


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Thr Cys Arg Gln Ser Gly 
                165                 170                 175     


Asp Leu Thr Tyr Asp Cys Ala Cys Leu Pro Gly Phe Glu Gly Gln Asn 
            180                 185                 190         


Cys Glu Val Asn Val Asp Asp Cys Pro Gly His Arg Cys Leu Asn Gly 
        195                 200                 205             


Gly Thr Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Gln Cys Pro Pro 
    210                 215                 220                 


Glu Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Gln Leu 
225                 230                 235                 240 


Gln Pro Asn Ala Cys His Asn Gly Gly Thr Cys Phe Asn Thr Leu Gly 
                245                 250                 255     


Gly His Ser Cys Val Cys Val Asn Gly Trp Thr Gly Glu Ser Cys Ser 
            260                 265                 270         


Gln Asn Ile Asp Asp Cys Ala Thr Ala Val Cys Phe His Gly Ala Thr 
        275                 280                 285             


Cys His Asp Arg Val Ala Ser Phe Tyr Cys Ala Cys Pro Met Gly Lys 
    290                 295                 300                 


Thr Gly Leu Leu Cys His Leu Asp Asp Ala Cys Val Ser Asn Pro Cys 
305                 310                 315                 320 


His Glu Asp Ala Ile Cys Asp Thr Asn Pro Val Asn Gly Arg Ala Ile 
                325                 330                 335     


Cys Thr Cys Pro Pro Gly Phe Thr Gly Gly Ala Cys Asp Gln Asp Val 
            340                 345                 350         


Asp Glu Cys Ser Ile Gly Ala Asn Pro Cys Glu His Leu Gly Arg Cys 
        355                 360                 365             


Val Asn Thr Gln Gly Ser Phe Leu Cys Gln Cys Gly Arg Gly Tyr Thr 
    370                 375                 380                 


Gly Pro Arg Cys Glu Thr Asp Val Asn Glu Cys Leu Ser Gly Pro Cys 
385                 390                 395                 400 


Arg Asn Gln Ala Thr Cys Leu Asp Arg Ile Gly Gln Phe Thr Cys Ile 
                405                 410                 415     


Cys Met Ala Gly Phe Thr Gly Thr Tyr Cys Glu Val Asp Ile Asp Glu 
            420                 425                 430         


Cys Gln Ser Ser Pro Cys Val Asn Gly Gly Val Cys Lys Asp Arg Val 
        435                 440                 445             


Asn Gly Phe Ser Cys Thr Cys Pro Ser Gly Phe Ser Gly Ser Thr Cys 
    450                 455                 460                 


Gln Leu Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Arg Asn Gly Ala 
465                 470                 475                 480 


Lys Cys Val Asp Gln Pro Asp Gly Tyr Glu Cys Arg Cys Ala Glu Gly 
                485                 490                 495     


Phe Glu Gly Thr Leu Cys Asp Arg Asn Val Asp Asp Cys Ser Pro Asp 
            500                 505                 510         


Pro Cys His His Gly Arg Cys Val Asp Gly Ile Ala Ser Phe Ser Cys 
        515                 520                 525             


Ala Cys Ala Pro Gly Tyr Thr Gly Thr Arg Cys Glu Ser Gln Val Asp 
    530                 535                 540                 


Glu Cys Arg Ser Gln Pro Cys Arg His Gly Gly Lys Cys Leu Asp Leu 
545                 550                 555                 560 


Val Asp Lys Tyr Leu Cys Arg Cys Pro Ser Gly Thr Thr Gly Val Asn 
                565                 570                 575     


Cys Glu Val Asn Ile Asp Asp Cys Ala Ser Asn Pro Cys Thr Phe Gly 
            580                 585                 590         


Val Cys Arg Asp Gly Ile Asn Arg Tyr Asp Cys Val Cys Gln Pro Gly 
        595                 600                 605             


Phe Thr Gly Pro Leu Cys Asn Val Glu Ile Asn Glu Cys Ala Ser Ser 
    610                 615                 620                 


Pro Cys Gly Glu Gly Gly Ser Cys Val Asp Gly Glu Asn Gly Phe Arg 
625                 630                 635                 640 


Cys Leu Cys Pro Pro Gly Ser Leu Pro Pro Leu Cys Leu Pro Pro Ser 
                645                 650                 655     


His Pro Cys Ala His Glu Pro Cys Ser His Gly Ile Cys Tyr Asp Ala 
            660                 665                 670         


Pro Gly Gly Phe Arg Cys Val Cys Glu Pro Gly Trp Ser Gly Pro Arg 
        675                 680                 685             


Cys Ser Gln Ser Leu Ala Arg Asp Ala Cys Glu Ser Gln Pro Cys Arg 
    690                 695                 700                 


Ala Gly Gly Thr Cys Ser Ser Asp Gly Met Gly Phe His Cys Thr Cys 
705                 710                 715                 720 


Pro Pro Gly Val Gln Gly Arg Gln Cys Glu Leu Leu Ser Pro Cys Thr 
                725                 730                 735     


Pro Asn Pro Cys Glu His Gly Gly Arg Cys Glu Ser Ala Pro Gly Gln 
            740                 745                 750         


Leu Pro Val Cys Ser Cys Pro Gln Gly Trp Gln Gly Pro Arg Cys Gln 
        755                 760                 765             


Gln Asp Val Asp Glu Cys Ala Gly Pro Ala Pro Cys Gly Pro His Gly 
    770                 775                 780                 


Ile Cys Thr Asn Leu Ala Gly Ser Phe Ser Cys Thr Cys His Gly Gly 
785                 790                 795                 800 


Tyr Thr Gly Pro Ser Cys Asp Gln Asp Ile Asn Asp Cys Asp Pro Asn 
                805                 810                 815     


Pro Cys Leu Asn Gly Gly Ser Cys Gln Asp Gly Val Gly Ser Phe Ser 
            820                 825                 830         


Cys Ser Cys Leu Pro Gly Phe Ala Gly Pro Arg Cys Ala Arg Asp Val 
        835                 840                 845             


Asp Glu Cys Leu Ser Asn Pro Cys Gly Pro Gly Thr Cys Thr Asp His 
    850                 855                 860                 


Val Ala Ser Phe Thr Cys Thr Cys Pro Pro Gly Tyr Gly Gly Phe His 
865                 870                 875                 880 


Cys Glu Gln Asp Leu Pro Asp Cys Ser Pro Ser Ser Cys Phe Asn Gly 
                885                 890                 895     


Gly Thr Cys Val Asp Gly Val Asn Ser Phe Ser Cys Leu Cys Arg Pro 
            900                 905                 910         


Gly Tyr Thr Gly Ala His Cys Gln His Glu Ala Asp Pro Cys Leu Ser 
        915                 920                 925             


Arg Pro Cys Leu His Gly Gly Val Cys Ser Ala Ala His Pro Gly Phe 
    930                 935                 940                 


Arg Cys Thr Cys Leu Glu Ser Phe Thr Gly Pro Gln Cys Gln Thr Leu 
945                 950                 955                 960 


Val Asp Trp Cys Ser Arg Gln Pro Cys Gln Asn Gly Gly Arg Cys Val 
                965                 970                 975     


Gln Thr Gly Ala Tyr Cys Leu Cys Pro Pro Gly Trp Ser Gly Arg Leu 
            980                 985                 990         


Cys Asp Ile Arg Ser Leu Pro Cys  Arg Glu Ala Ala Ala  Gln Ile Gly 
        995                 1000                 1005             


Val Arg  Leu Glu Gln Leu Cys  Gln Ala Gly Gly Gln  Cys Val Asp 
    1010                 1015                 1020             


Glu Asp  Ser Ser His Tyr Cys  Val Cys Pro Glu Gly  Arg Thr Gly 
    1025                 1030                 1035             


Ser His  Cys Glu Gln Glu Val  Asp Pro Cys Leu Ala  Gln Pro Cys 
    1040                 1045                 1050             


Gln His  Gly Gly Thr Cys Arg  Gly Tyr Met Gly Gly  Tyr Met Cys 
    1055                 1060                 1065             


Glu Cys  Leu Pro Gly Tyr Asn  Gly Asp Asn Cys Glu  Asp Asp Val 
    1070                 1075                 1080             


Asp Glu  Cys Ala Ser Gln Pro  Cys Gln His Gly Gly  Ser Cys Ile 
    1085                 1090                 1095             


Asp Leu  Val Ala Arg Tyr Leu  Cys Ser Cys Pro Pro  Gly Thr Leu 
    1100                 1105                 1110             


Gly Val  Leu Cys Glu Ile Asn  Glu Asp Asp Cys Gly  Pro Gly Pro 
    1115                 1120                 1125             


Pro Leu  Asp Ser Gly Pro Arg  Cys Leu His Asn Gly  Thr Cys Val 
    1130                 1135                 1140             


Asp Leu  Val Gly Gly Phe Arg  Cys Thr Cys Pro Pro  Gly Tyr Thr 
    1145                 1150                 1155             


Gly Leu  Arg Cys Glu Ala Asp  Ile Asn Glu Cys Arg  Ser Gly Ala 
    1160                 1165                 1170             


Cys His  Ala Ala His Thr Arg  Asp Cys Leu Gln Asp  Pro Gly Gly 
    1175                 1180                 1185             


Gly Phe  Arg Cys Leu Cys His  Ala Gly Phe Ser Gly  Pro Arg Cys 
    1190                 1195                 1200             


Gln Thr  Val Leu Ser Pro Cys  Glu Ser Gln Pro Cys  Gln His Gly 
    1205                 1210                 1215             


Gly Gln  Cys Arg Pro Ser Pro  Gly Pro Gly Gly Gly  Leu Thr Phe 
    1220                 1225                 1230             


Thr Cys  His Cys Ala Gln Pro  Phe Trp Gly Pro Arg  Cys Glu Arg 
    1235                 1240                 1245             


Val Ala  Arg Ser Cys Arg Glu  Leu Gln Cys Pro Val  Gly Val Pro 
    1250                 1255                 1260             


Cys Gln  Gln Thr Pro Arg Gly  Pro Arg Cys Ala Cys  Pro Pro Gly 
    1265                 1270                 1275             


Leu Ser  Gly Pro Ser Cys Arg  Ser Phe Pro Gly Ser  Pro Pro Gly 
    1280                 1285                 1290             


Ala Ser  Asn Ala Ser Cys Ala  Ala Ala Pro Cys Leu  His Gly Gly 
    1295                 1300                 1305             


Ser Cys  Arg Pro Ala Pro Leu  Ala Pro Phe Phe Arg  Cys Ala Cys 
    1310                 1315                 1320             


Ala Gln  Gly Trp Thr Gly Pro  Arg Cys Glu Ala Pro  Ala Ala Ala 
    1325                 1330                 1335             


Pro Glu  Val Ser Glu Glu Pro  Arg Cys Pro Arg Ala  Ala Cys Gln 
    1340                 1345                 1350             


Ala Lys  Arg Gly Asp Gln Arg  Cys Asp Arg Glu Cys  Asn Ser Pro 
    1355                 1360                 1365             


Gly Cys  Gly Trp Asp Gly Gly  Asp Cys Ser Leu Ser  Val Gly Asp 
    1370                 1375                 1380             


Pro Trp  Arg Gln Cys Glu Ala  Leu Gln Cys Trp Arg  Leu Phe Asn 
    1385                 1390                 1395             


Asn Ser  Arg Cys Asp Pro Ala  Cys Ser Ser Pro Ala  Cys Leu Tyr 
    1400                 1405                 1410             


Asp Asn  Phe Asp Cys His Ala  Gly Gly Arg Glu Arg  Thr Cys Asn 
    1415                 1420                 1425             


Pro Val  Tyr Glu Lys Tyr Cys  Ala Asp His Phe Ala  Asp Gly Arg 
    1430                 1435                 1440             


Cys Asp  Gln Gly Cys Asn Thr  Glu Glu Cys Gly Trp  Asp Gly Leu 
    1445                 1450                 1455             


Asp Cys  Ala Ser Glu Val Pro  Ala Leu Leu Ala Arg  Gly Val Leu 
    1460                 1465                 1470             


Val Leu  Thr Val Leu Leu Pro  Pro Glu Glu Leu Leu  Arg Ser Ser 
    1475                 1480                 1485             


Ala Asp  Phe Leu Gln Arg Leu  Ser Ala Ile Leu Arg  Thr Ser Leu 
    1490                 1495                 1500             


Arg Phe  Arg Leu Asp Ala His  Gly Gln Ala Met Val  Phe Pro Tyr 
    1505                 1510                 1515             


His Arg  Pro Ser Pro Gly Ser  Glu Pro Arg Ala Arg  Arg Glu Leu 
    1520                 1525                 1530             


Ala Pro  Glu Val Ile Gly Ser  Val Val Met Leu Glu  Ile Asp Asn 
    1535                 1540                 1545             


Arg Leu  Cys Leu Gln Ser Pro  Glu Asn Asp His Cys  Phe Pro Asp 
    1550                 1555                 1560             


Ala Gln  Ser Ala Ala Asp Tyr  Leu Gly Ala Leu Ser  Ala Val Glu 
    1565                 1570                 1575             


Arg Leu  Asp Phe Pro Tyr Pro  Leu Arg Asp Val Arg  Gly Glu Pro 
    1580                 1585                 1590             


Leu Glu  Pro Pro Glu Pro Ser  Val Pro Leu Leu Pro  Leu Leu Val 
    1595                 1600                 1605             


Ala Gly  Ala Val Leu Leu Leu  Val Ile Leu Val Leu  Gly Val Met 
    1610                 1615                 1620             


Val Ala  Arg Arg Lys Arg Glu  His Ser Thr Leu Trp  Phe Pro Glu 
    1625                 1630                 1635             


Gly Phe  Ser Leu His Lys Asp  Val Ala Ser Gly His  Lys Gly Arg 
    1640                 1645                 1650             


Arg Glu  Pro Val Gly Gln Asp  Ala Leu Gly Met Lys  Asn Met Ala 
    1655                 1660                 1665             


Lys Gly  Glu Ser Leu Met Gly  Glu Val Ala Thr Asp  Trp Met Asp 
    1670                 1675                 1680             


Thr Glu  Cys Pro Glu Ala Lys  Arg Leu Lys Val Glu  Glu Pro Gly 
    1685                 1690                 1695             


Met Gly  Ala Glu Glu Ala Val  Asp Cys Arg Gln Trp  Thr Gln His 
    1700                 1705                 1710             


His Leu  Val Ala Ala Asp Ile  Arg Val Ala Pro Ala  Met Ala Leu 
    1715                 1720                 1725             


Thr Pro  Pro Gln Gly Asp Ala  Asp Ala Asp Gly Met  Asp Val Asn 
    1730                 1735                 1740             


Val Arg  Gly Pro Asp Gly Phe  Thr Pro Leu Met Leu  Ala Ser Phe 
    1745                 1750                 1755             


Cys Gly  Gly Ala Leu Glu Pro  Met Pro Thr Glu Glu  Asp Glu Ala 
    1760                 1765                 1770             


Asp Asp  Thr Ser Ala Ser Ile  Ile Ser Asp Leu Ile  Cys Gln Gly 
    1775                 1780                 1785             


Ala Gln  Leu Gly Ala Arg Thr  Asp Arg Thr Gly Glu  Thr Ala Leu 
    1790                 1795                 1800             


His Leu  Ala Ala Arg Tyr Ala  Arg Ala Asp Ala Ala  Lys Arg Leu 
    1805                 1810                 1815             


Leu Asp  Ala Gly Ala Asp Thr  Asn Ala Gln Asp His  Ser Gly Arg 
    1820                 1825                 1830             


Thr Pro  Leu His Thr Ala Val  Thr Ala Asp Ala Gln  Gly Val Phe 
    1835                 1840                 1845             


Gln Ile  Leu Ile Arg Asn Arg  Ser Thr Asp Leu Asp  Ala Arg Met 
    1850                 1855                 1860             


Ala Asp  Gly Ser Thr Ala Leu  Ile Leu Ala Ala Arg  Leu Ala Val 
    1865                 1870                 1875             


Glu Gly  Met Val Glu Glu Leu  Ile Ala Ser His Ala  Asp Val Asn 
    1880                 1885                 1890             


Ala Val  Asp Glu Leu Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala 
    1895                 1900                 1905             


Val Asn  Asn Val Glu Ala Thr  Leu Ala Leu Leu Lys  Asn Gly Ala 
    1910                 1915                 1920             


Asn Lys  Asp Met Gln Asp Ser  Lys Glu Glu Thr Pro  Leu Phe Leu 
    1925                 1930                 1935             


Ala Ala  Arg Glu Gly Ser Tyr  Glu Ala Ala Lys Leu  Leu Leu Asp 
    1940                 1945                 1950             


His Phe  Ala Asn Arg Glu Ile  Thr Asp His Leu Asp  Arg Leu Pro 
    1955                 1960                 1965             


Arg Asp  Val Ala Gln Glu Arg  Leu His Gln Asp Ile  Val Arg Leu 
    1970                 1975                 1980             


Leu Asp  Gln Pro Ser Gly Pro  Arg Ser Pro Pro Gly  Pro His Gly 
    1985                 1990                 1995             


Leu Gly  Pro Leu Leu Cys Pro  Pro Gly Ala Phe Leu  Pro Gly Leu 
    2000                 2005                 2010             


Lys Ala  Ala Gln Ser Gly Ser  Lys Lys Ser Arg Arg  Pro Pro Gly 
    2015                 2020                 2025             


Lys Ala  Gly Leu Gly Pro Gln  Gly Pro Arg Gly Arg  Gly Lys Lys 
    2030                 2035                 2040             


Leu Thr  Leu Ala Cys Pro Gly  Pro Leu Ala Asp Ser  Ser Val Thr 
    2045                 2050                 2055             


Leu Ser  Pro Val Asp Ser Leu  Asp Ser Pro Arg Pro  Phe Gly Gly 
    2060                 2065                 2070             


Pro Pro  Ala Ser Pro Gly Gly  Phe Pro Leu Glu Gly  Pro Tyr Ala 
    2075                 2080                 2085             


Ala Ala  Thr Ala Thr Ala Val  Ser Leu Ala Gln Leu  Gly Gly Pro 
    2090                 2095                 2100             


Gly Arg  Ala Gly Leu Gly Arg  Gln Pro Pro Gly Gly  Cys Val Leu 
    2105                 2110                 2115             


Ser Leu  Gly Leu Leu Asn Pro  Val Ala Val Pro Leu  Asp Trp Ala 
    2120                 2125                 2130             


Arg Leu  Pro Pro Pro Ala Pro  Pro Gly Pro Ser Phe  Leu Leu Pro 
    2135                 2140                 2145             


Leu Ala  Pro Gly Pro Gln Leu  Leu Asn Pro Gly Thr  Pro Val Ser 
    2150                 2155                 2160             


Pro Gln  Glu Arg Pro Pro Pro  Tyr Leu Ala Val Pro  Gly His Gly 
    2165                 2170                 2175             


Glu Glu  Tyr Pro Ala Ala Gly  Ala His Ser Ser Pro  Pro Lys Ala 
    2180                 2185                 2190             


Arg Phe  Leu Arg Val Pro Ser  Glu His Pro Tyr Leu  Thr Pro Ser 
    2195                 2200                 2205             


Pro Glu  Ser Pro Glu His Trp  Ala Ser Pro Ser Pro  Pro Ser Leu 
    2210                 2215                 2220             


Ser Asp  Trp Ser Glu Ser Thr  Pro Ser Pro Ala Thr  Ala Thr Gly 
    2225                 2230                 2235             


Ala Met  Ala Thr Thr Thr Gly  Ala Leu Pro Ala Gln  Pro Leu Pro 
    2240                 2245                 2250             


Leu Ser  Val Pro Ser Ser Leu  Ala Gln Ala Gln Thr  Gln Leu Gly 
    2255                 2260                 2265             


Pro Gln  Pro Glu Val Thr Pro  Lys Arg Gln Val Leu  Ala 
    2270                 2275                 2280     


<210>  4
<211>  2003
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210>  5
<211>  1218
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Arg Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asp Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  6
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  7
<211>  1238
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
            340                 345                 350         


Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
        355                 360                 365             


Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
    370                 375                 380                 


Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
385                 390                 395                 400 


Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                405                 410                 415     


Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
            420                 425                 430         


Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
        435                 440                 445             


Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
    450                 455                 460                 


Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
465                 470                 475                 480 


Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                485                 490                 495     


Leu Glu Arg Asp Lys Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
            500                 505                 510         


Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
        515                 520                 525             


Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
    530                 535                 540                 


Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
545                 550                 555                 560 


Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                565                 570                 575     


Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
            580                 585                 590         


Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
        595                 600                 605             


His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
    610                 615                 620                 


Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
625                 630                 635                 640 


Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                645                 650                 655     


Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
            660                 665                 670         


Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
        675                 680                 685             


Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
    690                 695                 700                 


Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
705                 710                 715                 720 


Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                725                 730                 735     


Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
            740                 745                 750         


Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
        755                 760                 765             


Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
    770                 775                 780                 


Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
785                 790                 795                 800 


Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                805                 810                 815     


Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
            820                 825                 830         


Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
        835                 840                 845             


Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
    850                 855                 860                 


Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
865                 870                 875                 880 


His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                885                 890                 895     


Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
            900                 905                 910         


Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
        915                 920                 925             


Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
    930                 935                 940                 


Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
945                 950                 955                 960 


Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                965                 970                 975     


Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
            980                 985                 990         


Ser Gly Ile Arg Ser Leu Pro Ala  Thr Arg Ala Val Ala  Arg Asp Arg 
        995                 1000                 1005             


Leu Leu  Val Leu Leu Cys Asp  Arg Ala Ser Ser Gly  Ala Ser Ala 
    1010                 1015                 1020             


Val Glu  Val Ala Val Ser Phe  Ser Pro Ala Arg Asp  Leu Pro Asp 
    1025                 1030                 1035             


Ser Ser  Leu Ile Gln Gly Ala  Ala His Ala Ile Val  Ala Ala Ile 
    1040                 1045                 1050             


Thr Gln  Arg Gly Asn Ser Ser  Leu Leu Leu Ala Val  Thr Glu Val 
    1055                 1060                 1065             


Lys Val  Glu Thr Val Val Thr  Gly Gly Ser Ser Thr  Gly Leu Leu 
    1070                 1075                 1080             


Val Pro  Val Leu Cys Gly Ala  Phe Ser Val Leu Trp  Leu Ala Cys 
    1085                 1090                 1095             


Val Val  Leu Cys Val Trp Trp  Thr Arg Lys Arg Arg  Lys Glu Arg 
    1100                 1105                 1110             


Glu Arg  Ser Arg Leu Pro Arg  Glu Glu Ser Ala Asn  Asn Gln Trp 
    1115                 1120                 1125             


Ala Pro  Leu Asn Pro Ile Arg  Asn Pro Ile Glu Arg  Pro Gly Gly 
    1130                 1135                 1140             


His Lys  Asp Val Leu Tyr Gln  Cys Lys Asn Phe Thr  Pro Pro Pro 
    1145                 1150                 1155             


Arg Arg  Ala Asp Glu Ala Leu  Pro Gly Pro Ala Gly  His Ala Ala 
    1160                 1165                 1170             


Val Arg  Glu Asp Glu Glu Asp  Glu Asp Leu Gly Arg  Gly Glu Glu 
    1175                 1180                 1185             


Asp Ser  Leu Glu Ala Glu Lys  Phe Leu Ser His Lys  Phe Thr Lys 
    1190                 1195                 1200             


Asp Pro  Gly Arg Ser Pro Gly  Arg Pro Ala His Trp  Ala Ser Gly 
    1205                 1210                 1215             


Pro Lys  Val Asp Asn Arg Ala  Val Arg Ser Ile Asn  Glu Ala Arg 
    1220                 1225                 1230             


Tyr Val  Gly Lys Glu 
    1235             


<210>  8
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  9
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Glu Glu Met Gly Asp Glu Glu Val His Thr 
        355                 360                 365             


Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro Ala 
    370                 375                 380                 


Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly Leu 
385                 390                 395                 400 


Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu Gly 
                405                 410                 415     


Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile Gln 
            420                 425                 430         


Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val Asp 
        435                 440                 445             


Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala Val 
    450                 455                 460                 


Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val Thr 
465                 470                 475                 480 


Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe Val 
                485                 490                 495     


Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser Ala 
            500                 505                 510         


Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro Ala 
        515                 520                 525             


Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu Ser 
    530                 535                 540                 


Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser Leu 
545                 550                 555                 560 


Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln Val 
                565                 570                 575     


Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr Phe 
            580                 585                 590         


Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln Gly 
        595                 600                 605             


Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser Val 
    610                 615                 620                 


Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe Ile 
625                 630                 635                 640 


Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile Glu 
                645                 650                 655     


Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys Arg 
            660                 665                 670         


Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe Ser 
        675                 680                 685             


Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln Cys 
    690                 695                 700                 


Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu Pro 
705                 710                 715                 720 


Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser Ile 
                725                 730                 735     


Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala 
            740                 745                 750         


Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met Lys 
        755                 760                 765             


Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr Leu 
    770                 775                 780                 


Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu Leu 
785                 790                 795                 800 


Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala Gly 
                805                 810                 815     


Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser Ala 
            820                 825                 830         


Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser Ser 
        835                 840                 845             


Thr Ala 
    850 


<210>  10
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Val Asn Asp Ser Val Thr Lys Ser Ile Val Ala Leu Arg Leu Thr 
1               5                   10                  15      


Leu Val Val Lys Val Ser Thr Cys Val Pro Gly Glu Ser His Ala Asn 
            20                  25                  30          


Asp Leu Glu Cys Ser Gly Lys Gly Lys Cys Thr Thr Lys Pro Ser Glu 
        35                  40                  45              


Ala Thr Phe Ser Cys Thr Cys Glu Glu Gln Tyr Val Gly Thr Phe Cys 
    50                  55                  60                  


Glu Glu Tyr Asp Ala Cys Gln Arg Lys Pro Cys Gln Asn Asn Ala Ser 
65                  70                  75                  80  


Cys Ile Asp Ala Asn Glu Lys Gln Asp Gly Ser Asn Phe Thr Cys Val 
                85                  90                  95      


Cys Leu Pro Gly Tyr Thr Gly Glu Leu Cys Gln Ser Lys Ile Asp Tyr 
            100                 105                 110         


Cys Ile Leu Asp Pro Cys Arg Asn Gly Ala Thr Cys Ile Ser Ser Leu 
        115                 120                 125             


Ser Gly Phe Thr Cys Gln Cys Pro Glu Gly Tyr Phe Gly Ser Ala Cys 
    130                 135                 140                 


Glu Glu Lys Val Asp Pro Cys Ala Ser Ser Pro Cys Gln Asn Asn Gly 
145                 150                 155                 160 


Thr Cys Tyr Val Asp Gly Val His Phe Thr Cys Asn Cys Ser Pro Gly 
                165                 170                 175     


Phe Thr Gly Pro Thr Cys Ala Gln Leu Ile Asp Phe Cys Ala Leu Ser 
            180                 185                 190         


Pro Cys Ala His Gly Thr Cys Arg Ser Val Gly Thr Ser Tyr Lys Cys 
        195                 200                 205             


Leu Cys Asp Pro Gly Tyr His Gly Leu Tyr Cys Glu Glu Glu Tyr Asn 
    210                 215                 220                 


Glu Cys Leu Ser Ala Pro Cys Leu Asn Ala Ala Thr Cys Arg Asp Leu 
225                 230                 235                 240 


Val Asn Gly Tyr Glu Cys Val Cys Leu Ala Glu Tyr Lys Gly Thr His 
                245                 250                 255     


Cys Glu Leu Tyr Lys Asp Pro Cys Ala Asn Val Ser Cys Leu Asn Gly 
            260                 265                 270         


Ala Thr Cys Asp Ser Asp Gly Leu Asn Gly Thr Cys Ile Cys Ala Pro 
        275                 280                 285             


Gly Phe Thr Gly Glu Glu Cys Asp Ile Asp Ile Asn Glu Cys Asp Ser 
    290                 295                 300                 


Asn Pro Cys His His Gly Gly Ser Cys Leu Asp Gln Pro Asn Gly Tyr 
305                 310                 315                 320 


Asn Cys His Cys Pro His Gly Trp Val Gly Ala Asn Cys Glu Ile His 
                325                 330                 335     


Leu Gln Trp Lys Ser Gly His Met Ala Glu Ser Leu Thr Asn Met Pro 
            340                 345                 350         


Arg His Ser Leu Tyr Ile Ile Ile Gly Ala Leu Cys Val Ala Phe Ile 
        355                 360                 365             


Leu Met Leu Ile Ile Leu Ile Val Gly Ile Cys Arg Ile Ser Arg Ile 
    370                 375                 380                 


Glu Tyr Gln Gly Ser Ser Arg Pro Ala Tyr Glu Glu Phe Tyr Asn Cys 
385                 390                 395                 400 


Arg Ser Ile Asp Ser Glu Phe Ser Asn Ala Ile Ala Ser Ile Arg His 
                405                 410                 415     


Ala Arg Phe Gly Lys Lys Ser Arg Pro Ala Met Tyr Asp Val Ser Pro 
            420                 425                 430         


Ile Ala Tyr Glu Asp Tyr Ser Pro Asp Asp Lys Pro Leu Val Thr Leu 
        435                 440                 445             


Ile Lys Thr Lys Asp Leu 
    450                 


<210>  11
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Thr Ser Phe Leu Pro Ala Pro Thr Gln Leu Ser Gln Asp 
1               5                   10                  15      


Gln Leu Glu Ala Glu Glu Lys Ala Arg Ser Gln Arg Ser Arg Gln Thr 
            20                  25                  30          


Ser Leu Val Ser Ser Arg Arg Glu Pro Pro Pro Tyr Gly Tyr Arg Lys 
        35                  40                  45              


Gly Trp Ile Pro Arg Leu Leu Glu Asp Phe Gly Asp Gly Gly Ala Phe 
    50                  55                  60                  


Pro Glu Ile His Val Ala Gln Tyr Pro Leu Asp Met Gly Arg Lys Lys 
65                  70                  75                  80  


Lys Met Ser Asn Ala Leu Ala Ile Gln Val Asp Ser Glu Gly Lys Ile 
                85                  90                  95      


Lys Tyr Asp Ala Ile Ala Arg Gln Gly Gln Ser Lys Asp Lys Val Ile 
            100                 105                 110         


Tyr Ser Lys Tyr Thr Asp Leu Val Pro Lys Glu Val Met Asn Ala Asp 
        115                 120                 125             


Asp Pro Asp Leu Gln Arg Pro Asp Glu Glu Ala Ile Lys Glu Ile Thr 
    130                 135                 140                 


Glu Lys Thr Arg Val Ala Leu Glu Lys Ser Val Ser Gln Lys Val Ala 
145                 150                 155                 160 


Ala Ala Met Pro Val Arg Ala Ala Asp Lys Leu Ala Pro Ala Gln Tyr 
                165                 170                 175     


Ile Arg Tyr Thr Pro Ser Gln Gln Gly Val Ala Phe Asn Ser Gly Ala 
            180                 185                 190         


Lys Gln Arg Val Ile Arg Met Val Glu Met Gln Lys Asp Pro Met Glu 
        195                 200                 205             


Pro Pro Arg Phe Lys Ile Asn Lys Lys Ile Pro Arg Gly Pro Pro Ser 
    210                 215                 220                 


Pro Pro Ala Pro Val Met His Ser Pro Ser Arg Lys Met Thr Val Lys 
225                 230                 235                 240 


Glu Gln Gln Glu Trp Lys Ile Pro Pro Cys Ile Ser Asn Trp Lys Asn 
                245                 250                 255     


Ala Lys Gly Tyr Thr Ile Pro Leu Asp Lys Arg Leu Ala Ala Asp Gly 
            260                 265                 270         


Arg Gly Leu Gln Thr Val His Ile Asn Glu Asn Phe Ala Lys Leu Ala 
        275                 280                 285             


Glu Ala Leu Tyr Ile Ala Asp Arg Lys Ala Arg Glu Ala Val Glu Met 
    290                 295                 300                 


Arg Ala Gln Val Glu Arg Lys Met Ala Gln Lys Glu Lys Glu Lys His 
305                 310                 315                 320 


Glu Glu Lys Leu Arg Glu Met Ala Gln Lys Ala Arg Glu Arg Arg Ala 
                325                 330                 335     


Gly Ile Lys Thr His Val Glu Lys Glu Asp Gly Glu Ala Arg Glu Arg 
            340                 345                 350         


Asp Glu Ile Arg His Asp Arg Arg Lys Glu Arg Gln His Asp Arg Asn 
        355                 360                 365             


Leu Ser Arg Ala Ala Pro Asp Lys Arg Ser Lys Leu Gln Arg Asn Glu 
    370                 375                 380                 


Asn Arg Asp Ile Ser Glu Val Ile Ala Leu Gly Val Pro Asn Pro Arg 
385                 390                 395                 400 


Thr Ser Asn Glu Val Gln Tyr Asp Gln Arg Leu Phe Asn Gln Ser Lys 
                405                 410                 415     


Gly Met Asp Ser Gly Phe Ala Gly Gly Glu Asp Glu Ile Tyr Asn Val 
            420                 425                 430         


Tyr Asp Gln Ala Trp Arg Gly Gly Lys Asp Met Ala Gln Ser Ile Tyr 
        435                 440                 445             


Arg Pro Ser Lys Asn Leu Asp Lys Asp Met Tyr Gly Asp Asp Leu Glu 
    450                 455                 460                 


Ala Arg Ile Lys Thr Asn Arg Phe Val Pro Asp Lys Glu Phe Ser Gly 
465                 470                 475                 480 


Ser Asp Arg Arg Gln Arg Gly Arg Glu Gly Pro Val Gln Phe Glu Glu 
                485                 490                 495     


Asp Pro Phe Gly Leu Asp Lys Phe Leu Glu Glu Ala Lys Gln His Gly 
            500                 505                 510         


Gly Ser Lys Arg Pro Ser Asp Ser Ser Arg Pro Lys Glu His Glu His 
        515                 520                 525             


Glu Gly Lys Lys Arg Arg Lys Glu 
    530                 535     


<210>  12
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp His Thr Glu Gly Ser Pro Ala Glu Glu Pro Pro Ala His Ala 
1               5                   10                  15      


Pro Ser Pro Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu Thr 
            20                  25                  30          


Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr Val 
        35                  40                  45              


Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu Lys 
    50                  55                  60                  


Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly Trp 
65                  70                  75                  80  


Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln Glu 
                85                  90                  95      


Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu Met 
            100                 105                 110         


Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr Leu 
        115                 120                 125             


Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val Lys 
    130                 135                 140                 


Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys Arg 
145                 150                 155                 160 


Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys Asn 
                165                 170                 175     


Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn Arg 
            180                 185                 190         


Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly Gly 
        195                 200                 205             


Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His Leu 
    210                 215                 220                 


Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp Gly 
225                 230                 235                 240 


Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr Gly 
                245                 250                 255     


Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr Ala 
            260                 265                 270         


Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala Phe 
        275                 280                 285             


Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu Arg 
    290                 295                 300                 


Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys Glu 
305                 310                 315                 320 


Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys Ala 
                325                 330                 335     


Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val Thr 
            340                 345                 350         


Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp Val 
        355                 360                 365             


Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg Val 
    370                 375                 380                 


Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu Ser 
385                 390                 395                 400 


Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp Arg 
                405                 410                 415     


Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn Asp 
            420                 425                 430         


Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu Pro 
        435                 440                 445             


Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala Asn 
    450                 455                 460                 


Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly Ser 
465                 470                 475                 480 


Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr Ala 
                485                 490                 495     


Thr Val Val Ser 
            500 


<210>  13
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Pro Ser Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys 
1               5                   10                  15      


Asn Arg Leu Arg Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile 
            20                  25                  30          


Asn Ser Ser Ile Glu Gln Leu Lys Leu Leu Leu Glu Gln Glu Phe Ala 
        35                  40                  45              


Arg His Gln Pro Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met 
    50                  55                  60                  


Ala Val Ser Tyr Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Lys Ser Leu His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu 
                85                  90                  95      


Gln Glu Ala Val Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln 
            100                 105                 110         


Met Lys Leu Leu Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Lys Glu Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu 
    130                 135                 140                 


Ser Ala Lys Ala Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Trp Arg Pro Trp 
                165     


<210>  14
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Thr Arg Asp Arg Ala Glu Asn Arg Asp Gly Pro Lys Met Leu 
1               5                   10                  15      


Lys Pro Leu Val Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Ser Leu 
            20                  25                  30          


Glu Glu Leu Arg Leu Leu Leu Leu Glu Arg Thr Arg Asp Gln Asn Leu 
        35                  40                  45              


Arg Asn Pro Lys Leu Glu Lys Ala Glu Ile Leu Glu Phe Ala Val Gly 
    50                  55                  60                  


Tyr Leu Arg Glu Arg Ser Arg Val Glu Pro Pro Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Gly Val Pro Arg Ser Pro Val Gln Asp Ala Glu Ala Leu Ala Ser Cys 
                85                  90                  95      


Tyr Leu Ser Gly Phe Arg Glu Cys Leu Leu Arg Leu Ala Ala Phe Ala 
            100                 105                 110         


His Asp Ala Ser Pro Ala Ala Arg Ala Gln Leu Phe Ser Ala Leu His 
        115                 120                 125             


Gly Tyr Leu Arg Pro Lys Pro Pro Arg Pro Lys Pro Val Asp Pro Arg 
    130                 135                 140                 


Pro Pro Ala Pro Arg Pro Ser Leu Asp Pro Ala Ala Pro Ala Leu Gly 
145                 150                 155                 160 


Pro Ala Leu His Gln Arg Pro Pro Val His Gln Gly His Pro Ser Pro 
                165                 170                 175     


Arg Cys Ala Trp Ser Pro Ser Leu Cys Ser Pro Arg Ala Gly Asp Ser 
            180                 185                 190         


Gly Ala Pro Ala Pro Leu Thr Gly Leu Leu Pro Pro Pro Pro Pro Pro 
        195                 200                 205             


His Arg Gln Asp Gly Ala Pro Lys Ala Pro Leu Pro Pro Pro Pro Ala 
    210                 215                 220                 


Phe Trp Arg Pro Trp Pro 
225                 230 


<210>  15
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile 
        115                 120                 125             


Val Leu Gln Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg 
    130                 135                 140                 


Gly Lys Trp Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg 
145                 150                 155                 160 


Glu Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met 
                165                 170                 175     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp 
            180                 185                 190         


Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His 
        195                 200                 205             


Gly Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly 
    210                 215                 220                 


Met Ile Lys Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His 
225                 230                 235                 240 


Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                245                 250                 255     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile 
            260                 265                 270         


Ala Asp Leu Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile 
        275                 280                 285             


Asp Ile Ala Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    290                 295                 300                 


Glu Val Leu Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys 
305                 310                 315                 320 


Arg Ala Asp Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg 
                325                 330                 335     


Arg Cys Ser Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr 
            340                 345                 350         


Asp Leu Val Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val 
        355                 360                 365             


Cys Glu Gln Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys 
    370                 375                 380                 


Glu Ala Leu Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala 
385                 390                 395                 400 


Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser 
                405                 410                 415     


Gln Leu Ser Gln Gln Glu Gly Ile Lys Met 
            420                 425     


<210>  16
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  17
ggcagaccga gatgaatcct ca                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  18
caggtccagg ggtcttggtc c                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  19
ctgcaagata catggctcca                                                   20


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  20
ctcgatctct caacacgttg t                                                 21


<210>  21
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Trp Ile Lys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg 
1               5                   10                  15      


Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln 
            20                  25                  30          


Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn 
        35                  40                  45              


Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser 
    50                  55                  60                  


Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu 
65                  70                  75                  80  


Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln 
                85                  90                  95      


Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys 
            100                 105                 110         


Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser 
        115                 120                 125             


Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser 
    130                 135                 140                 


Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu 
145                 150                 155                 160 


Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe 
                165                 170                 175     


Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu 
            180                 185                 190         


Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile 
        195                 200                 205             


His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg 
    210                 215                 220                 


Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val 
225                 230                 235                 240 


Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln 
                245                 250                 255     


Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys 
            260                 265                 270         


Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln 
        275                 280                 285             


Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn 
    290                 295                 300                 


Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp 
305                 310                 315                 320 


Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro 
                325                 330                 335     


Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly 
            340                 345                 350         


Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu 
        355                 360                 365             


Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly 
    370                 375                 380                 


Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly 
385                 390                 395                 400 


Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg 
                405                 410                 415     


Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro 
            420                 425                 430         


Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg 
        435                 440                 445             


Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu 
    450                 455                 460                 


Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser 
465                 470                 475                 480 


Thr Ala Thr Val Val Ser 
                485     


<210>  22
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Pro Val Val Thr Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys 
1               5                   10                  15      


Arg Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp 
            20                  25                  30          


Gln Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly 
        35                  40                  45              


Asn Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly 
    50                  55                  60                  


Ser Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser 
65                  70                  75                  80  


Glu Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp 
                85                  90                  95      


Gln Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala 
            100                 105                 110         


Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu 
        115                 120                 125             


Ser Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu 
    130                 135                 140                 


Ser Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser 
145                 150                 155                 160 


Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu 
                165                 170                 175     


Phe Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val 
            180                 185                 190         


Glu Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe 
        195                 200                 205             


Ile His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val 
    210                 215                 220                 


Arg Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser 
225                 230                 235                 240 


Val Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys 
                245                 250                 255     


Gln Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys 
            260                 265                 270         


Cys Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser 
        275                 280                 285             


Gln Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro 
    290                 295                 300                 


Asn Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala 
                325                 330                 335     


Pro Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly 
            340                 345                 350         


Gly Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn 
        355                 360                 365             


Leu Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys 
    370                 375                 380                 


Gly Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu 
385                 390                 395                 400 


Gly Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val 
                405                 410                 415     


Arg Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr 
            420                 425                 430         


Pro Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu 
        435                 440                 445             


Arg Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser 
    450                 455                 460                 


Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser 
465                 470                 475                 480 


Ser Thr Ala Thr Val Val Ser 
                485         


<210>  23
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Gly Cys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu 
1               5                   10                  15      


Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr 
            20                  25                  30          


Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu 
        35                  40                  45              


Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly 
    50                  55                  60                  


Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln 
65                  70                  75                  80  


Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu 
                85                  90                  95      


Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr 
            100                 105                 110         


Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val 
        115                 120                 125             


Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys 
    130                 135                 140                 


Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys 
145                 150                 155                 160 


Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn 
                165                 170                 175     


Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly 
            180                 185                 190         


Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His 
        195                 200                 205             


Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp 
    210                 215                 220                 


Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr 
225                 230                 235                 240 


Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr 
                245                 250                 255     


Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala 
            260                 265                 270         


Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu 
        275                 280                 285             


Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys 
    290                 295                 300                 


Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys 
305                 310                 315                 320 


Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val 
                325                 330                 335     


Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp 
            340                 345                 350         


Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg 
        355                 360                 365             


Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu 
    370                 375                 380                 


Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp 
385                 390                 395                 400 


Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn 
                405                 410                 415     


Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu 
            420                 425                 430         


Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala 
        435                 440                 445             


Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly 
    450                 455                 460                 


Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr 
465                 470                 475                 480 


Ala Thr Val Val Ser 
                485 


