                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  MULTISPECIFICS & H2 ANTIBODIES

<130>  P4422PC00

<140>  PCT/GB2013/051280
<141>  2013-05-17

<150>  GB1208708.6
<151>  2012-05-17

<160>  140   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220> 
<221> REPEAT
<222> (1)(5)n
<223>  linker n=1,2,3,4,5,6,7,8,9,10

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  2

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  3

Ala Lys Thr Thr Pro Lys Leu Asx Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


Val 
    


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  4

Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


Val 
    


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  7

Ser Ala Lys Thr Thr Pro 
1               5       


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  8

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  9

Arg Ala Asp Ala Ala Pro 
1               5       


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Arg Ala Asp Ala Ala Pro Thr Val Ser 
1               5                   


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  11

Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser 
1               5                   10          


<210>  12

<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (8) 4, (8)(9) 4
<223>  linker

<400>  12

Arg Ala Asp Ala Ala Ala Ala Gly Ser 
1               5                   


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Ser Ala Lys Thr Thr Pro 
1               5       


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  14

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  15

Ser Ala Lys Thr Thr Pro Lys Leu Glu Asx Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      


Arg Val 
        


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  16

Ala Asp Ala Ala Pro 
1               5   


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10          


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Thr Val Ala Ala Pro 
1               5   


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gln Pro Lys Ala Ala Pro 
1               5       


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Ala Lys Thr Thr Pro Pro 
1               5       


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  23

Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro 
1               5                   10              


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  24

Ala Lys Thr Thr Ala Pro 
1               5       


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  25

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  26

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  28

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  29

Gly Asx Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  30

Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  31

Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser 
1               5                   10                  15  


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  32

Gly Ser Thr Val Ala Ala Pro Ser 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  33

Thr Val Ala Ala Pro Ser Gly Ser 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  34

Gly Ser Thr Val Ala Ala Pro Ser Gly Ser 
1               5                   10  


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(3)n,(4)(5)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  35

Pro Ala Ser Gly Ser 
1               5   


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)n,(6)(7)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  36

Gly Gly Gly Gly Ser Gly Ser 
1               5           


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)n,(6)(7)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  37

Thr Val Ala Ala Pro Ser Gly Ser 
1               5               


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(2)m, (3)(10)n
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  38

Gly Ser Thr Val Ala Ala Pro Ser Gly Ser 
1               5                   10  


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n, (7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  39

Pro Ala Val Pro Pro Pro Gly Ser 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n,(7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  40

Thr Val Ser Asp Val Pro Gly Ser 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n,(7)8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4

<400>  41

Thr Gly Leu Asp Ser Pro Gly Ser 
1               5               


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  42

Thr Val Ala Ala Pro Ser 
1               5       


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  43

Thr Val Ala Ala Pro Ser Gly Ser 
1               5               


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  44

Ala Ser Thr Lys Gly Pro Thr 
1               5           


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(3)n,(4)(5)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  45

Pro Ala Ser Gly Ser 
1               5   


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)p,(6)(7)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  46

Gly Gly Gly Gly Ser Gly Ser 
1               5           


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)p,(7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  47

Thr Val Ala Ala Pro Ser Gly Ser 
1               5               


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(2)m,(3)(10)p
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  48

Gly Ser Thr Val Ala Ala Pro Ser Gly Ser 
1               5                   10  


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n, (7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  49

Pro Ala Val Pro Pro Pro Gly Ser 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n,(7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  50

Thr Val Ser Asp Val Pro Gly Ser 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)n,(7)(8)m
<223>  linker n=1,2,3,4,5,6,7,8,9,10, m=0,1,2,3,4, p=2,3,4,5,6,7,8,9,10

<400>  51

Thr Gly Leu Asp Ser Pro Gly Ser 
1               5               


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(6)p,(7)(8)m
<223>  linker m=0,1,2,3,4,5,6,7,8,9,10 p=2,3,4,5,6,7,8,9,10

<400>  52

Thr Val Ala Ala Pro Ser Gly Ser
1               5       


<210>  53
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  53
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga       60

cct                                                                     63


<210>  54
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide lox2272/66

<400>  54
ataacttcgt ataaagtatc ctatacgaac ggta                                   34


<210>  55
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide lox2272/71

<400>  55
taccgttcgt ataaagtatc ctatacgaag ttat                                   34


<210>  56
<211>  5458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  56
atctttcagg gacaatgatg cccatgcagg cagcatattt ataatgcaca gtaaacacta       60

ggaggaaaca aggcagtgag agaggaaaga gagcagcgat accgaaaatg tcctcagcga      120

gaagctacca cagaggatga atggagatca agcccacgtg gaaacatggg aaaatgtctc      180

agtatttttc cacctaagaa gggagggaga tggggtatgt atacacctcc ctgtcctcac      240

tgattgaggg ctttccgaga ggatgctcat tccaggtgct gtgataggcc atgtgtacag      300

gcagggctgc cttctccagc ttcagataga gcagtgagga aaagatatgg ccatgggggg      360

tcagcagaag tacagcaaag ggaaaaggga aagggtagca agagtgacaa ctatattcac      420

cccccccaca cacacacaca cacacacgaa attgtgtatt gcaatccaga actgcttctc      480

tctgaaccta aatcttagca agcagtttac cagtaactgc ccttgaaatt caggcccctg      540

gaaaggagca gggggttgtg tacaggctat accacagcag tctgcccacc cttagtgatg      600

catgagtaat gctccctgga ctccccaggt tctagtcttc tcatgtcgat gtagttgatt      660

ccacttccct tgctgcacaa ccaggctggg atgcctgggc agaggcagac atgtgaggta      720

taggggttca aatctgtttc caagttttat ccagcttcaa agcatttctc cgtgtacatg      780

agcggtggct tgacaggaga tggagactct ctttcctgga tgtgaggcaa ggaggcaggc      840

gtctgagtca ggatgatgtc cctactcact gctaaagaga aaagtggctt tgatggtgca      900

gggcagggaa atgcactgag tggtcgccac cctcacagaa gagaaagtgt tcactgacct      960

ggcctttccc cagggcctct ccctcccatt gctttccaga aagccatgat ttttgagagc     1020

cacacctgaa cactcacaaa cattatggtg ggaaaagcag atcagagcat taggcaagtt     1080

gcattacctt ggccttcttc ctttggagac aattgatgtg gggttctaga ttgacccaga     1140

gtttcaagtt tatcctgatt caggcttcaa cagctggagg aagaaacaga gatgtttttt     1200

gaagtaaaca gatctagcat tactaatcaa cccttcatac tgatgaccta tgggaaataa     1260

tacccaaggg cagaaaaatg ggcagaataa ggggagcccc aaaccaagac gaagctgctg     1320

cccattgaga ccctgggtat tacagagacc tatagctctg gataatggaa gatctatgag     1380

tggcacaggc gctgaggaat cacagcatca ttatcgtgca tctgcaggga attgcttgta     1440

aatatactgg taattacaaa tgtttaaggt cactacaaat actttggagt gtattaaata     1500

tgcttctgat aaagactgtt tttctcacat gaaacaatgg gaaccatgtg acaatcacag     1560

aggtgttgtt actatagcaa aagggattgt tactctccac atccctttaa gtaacttgaa     1620

ggcctgatag acccaccctc taagacttca ttagacattc cctacgaatg gttatactct     1680

cctgtatact cccaatacaa ctctaaaata tattattcca tatagtcctt aggtttgtat     1740

taaagtttga cttttttcct tcaaaatatc tcttgtcaca acagcggctc tagagagaaa     1800

tacattccct ccaggcaaat ctatgctgcg ctggtctgac ctgggaccct ggggacattg     1860

cccctgtgct gagttactaa gatgagccag ccctgcagct gtgctcagcc tgccccatgc     1920

cctgctgatt gatttgcatg ttccagagca cagccccctg ccctgaagac ttttttatgg     1980

gctggtcgca ccctgtgcag gagtcagtct cagtcaggac acagcatgga catgagggtc     2040

cccgctcagc tcctggggct cctgctactc tggctccgag gtaaggatgg agaacactag     2100

gaatttactc agccagtgtg ctcagtactg actggaactt cagggaagtt ctctgataac     2160

atgattaata gtaagaatat ttgtttttat gtttccaatc tcaggtgcca gatgtgacat     2220

ccagatgacc cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac     2280

ttgccgggca agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa     2340

agcccctaag ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt     2400

cagtggcagt ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga     2460

ttttgcaact tactactgtc aacagagtta cagtaccccg atcaccttcg gccaagggac     2520

acgactggag attaaacgta agtacacttt tctcatcttt ttttatgtgt aagacacagg     2580

ttttcatgtt aggagttaaa gtcagttcag aaaatcttga gaaaatggag agggctcatt     2640

atcagttgac gtggcataca gtgtcagatt ttctgtttat caagctagtg agattagggg     2700

caaaaagagg ctttagttga gaggaaagta attaatacta tggtcaccat ccaagagatt     2760

ggatcggaga ataagcatga gtagttattg agatctgggt ctgactgcag gtagcgtggt     2820

cttctagacg tttaagtggg agatttggag gggatgagga atgaaggaac ttcaggatag     2880

aaaagggctg aagtcaagtt cagctcctaa aatggatgtg ggagcaaact ttgaagataa     2940

actgaatgac ccagaggatg aaacagcgca gatcaaagag gggcctggag ctctgagaag     3000

agaaggagac tcatccgtgt tgagtttcca caagtactgt cttgagtttt gcaataaaag     3060

tgggatagca gagttgagtg agccgtaggc tgagttctct cttttgtctc ctaagttttt     3120

atgactacaa aaatcagtag tatgtcctga aataatcatt aagctgtttg aaagtatgac     3180

tgcttgccat gtagatacca tggcttgctg aataatcaga agaggtgtga ctcttattct     3240

aaaatttgtc acaaaatgtc aaaatgagag actctgtagg aacgagtcct tgacagacag     3300

ctcaaggggt ttttttcctt tgtctcattt ctacatgaaa gtaaatttga aatgatcttt     3360

tttattataa gagtagaaat acagttgggt ttgaactata tgttttaatg gccacggttt     3420

tgtaagacat ttggtccttt gttttcccag ttattactcg attgtaattt tatatcgcca     3480

gcaatggact gaaacggtcc gcaacctctt ctttacaact gggtgacctc gcggctgtgc     3540

cagccatttg gcgttcaccc tgccgctaag ggccatgtga acccccgcgg tagcatccct     3600

tgctccgcgt ggaccacttt cctgaggcac agtgatagga acagagccac taatctgaag     3660

agaacagaga tgtgacagac tacactaatg tgagaaaaac aaggaaaggg tgacttattg     3720

gagatttcag aaataaaatg catttattat tatattccct tattttaatt ttctattagg     3780

gaattagaaa gggcataaac tgctttatcc agtgttatat taaaagctta atgtatataa     3840

tcttttagag gtaaaatcta cagccagcaa aagtcatggt aaatattctt tgactgaact     3900

ctcactaaac tcctctaaat tatatgtcat attaactggt taaattaata taaatttgtg     3960

acatgacctt aactggttag gtaggatatt tttcttcatg caaaaatatg actaataata     4020

atttagcaca aaaatatttc ccaatacttt aattctgtga tagaaaaatg tttaactcag     4080

ctactataat cccataattt tgaaaactat ttattagctt ttgtgtttga cccttcccta     4140

gccaaaggca actatttaag gaccctttaa aactcttgaa actactttag agtcattaag     4200

ttatttaacc acttttaatt actttaaaat gatgtcaatt cccttttaac tattaattta     4260

ttttaagggg ggaaaggctg ctcataattc tattgttttt cttggtaaag aactctcagt     4320

tttcgttttt actacctctg tcacccaaga gttggcatct caacagaggg gactttccga     4380

gaggccatct ggcagttgct taagatcaga agtgaagtct gccagttcct cccaggcagg     4440

tggcccagat tacagttgac ctgttctggt gtggctaaaa attgtcccat gtggttacaa     4500

accattagac cagggtctga tgaattgctc agaatatttc tggacaccca aatacagacc     4560

ctggcttaag gccctgtcca tacagtaggt ttagcttggc tacaccaaag gaagccatac     4620

agaggctaat atcagagtat tcttggaaga gacaggagaa aatgaaagcc agtttctgct     4680

cttaccttat gtgcttgtgt tcagactccc aaacatcagg agtgtcagat aaactggtct     4740

gaatctctgt ctgaagcatg gaactgaaaa gaatgtagtt tcagggaaga aaggcaatag     4800

aaggaagcct gagaatatct tcaaagggtc agactcaatt tactttctaa agaagtagct     4860

aggaactagg gaataactta gaaacaacaa gataacttcg tataaagtat cctatacgaa     4920

cggtaattgt atatatgtgc atcctggccc cattgttcct tatctgtagg gataagcgtg     4980

cttttttgtg tgtctgtata taacataact gtttacacat aatacactga aatggagccc     5040

ttccttgtta cttcatacca tcctctgtgc ttccttcctc aggggctgat gctgcaccaa     5100

ctgtatccat cttcccacca tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt     5160

gcttcttgaa caacttctac cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg     5220

aacgacaaaa tggcgtcctg aacagttgga ctgatcagga cagcaaagac agcacctaca     5280

gcatgagcag caccctcacg ttgaccaagg acgagtatga acgacataac agctatacct     5340

gtgaggccac tcacaagaca tcaacttcac ccattgtcaa gagcttcaac aggaatgagt     5400

gttagagaca aaggtcctga gacgataact tcgtatagga tactttatac gaacggta       5458


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  57

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  58

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)3
<223>  linker sequence

<400>  59

Gly Gly Gly Gly Ser 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)3
<223>  linker sequence

<400>  60

Gly Gly Gly Gly Ser 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)2
<223>  linker sequence

<400>  61

Gly Gly Gly Gly Ser 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221> REPEAT
<222> (1)(5)2
<223>  linker sequence

<400>  62

Gly Gly Gly Gly Ser 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  63

Gly Gly Gly Gly Ser 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  64

Gly Gly Gly Gly Ser 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  65

Ala Lys Thr Thr Pro 
1               5   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  66

Ala Lys Thr Thr Pro Arg Leu Gly Gly 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  67

Glu Glu Gly Glu Phe Ser Glu Ala 
1               5               


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  68

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  69

Gly Gly Gly Gly Ser 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  70

Ala Lys Thr Thr Pro 
1               5   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  71

Ala Lys Thr Thr Pro Arg Leu Gly Gly 
1               5                   


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  72

Glu Glu Gly Glu Phe Ser Glu Ala 
1               5               


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  73

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  74
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  74
gtcgaaggtg gaagtggagg ttctggtgga agtggaggtt caggtggagt cgac             54


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  75

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  76
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  76
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttct                       45


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  78
ggcggcggcg gctccggtgg tggtggttct                                        30


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  79

Gly Gly Gly Gly Ser 
1               5   


<210>  80
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  80
ggaggtggtg gatcc                                                        15


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  81

Ala Lys Thr Thr Pro 
1               5   


<210>  82
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  82
gccaaaacaa caccc                                                        15


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  83

Ala Lys Thr Thr Pro Arg Leu Gly Gly 
1               5                   


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  84

Glu Glu Gly Glu Phe Ser Glu Ala 
1               5               


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  85
gaagaaggtg aattttcaga agca                                              24


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  86

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  87
ggtggttctg gtggttctgg tggttct                                           27


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  88

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  89
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  89
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttct                       45


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  90

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  91
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  91
ggcggcggcg gctccggtgg tggtggttct                                        30


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  92

Gly Gly Gly Gly Ser 
1               5   


<210>  93
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  93
ggaggtggtg gatcc                                                        15


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  94

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  95
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  95
gtcgaaggtg gaagtggagg ttctggtgga agtggaggtt caggtggagt cgac             54


<210>  96
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  97
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  97
caggtgcagc tggtggagtc cgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caagttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa gaaatactat      180

gtagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacaaatg      300

ggctactggc acttcgatct ctggggccgt ggcaccctgg tcactgtctc ctca            354


<210>  98
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  98

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  99
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  99
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  100
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Pro Tyr 
            20                  25                  30          


Gly Met His Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Leu Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Ile Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Tyr Trp His Phe Asp Leu Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  101
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  101
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  102
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = leucine or isoleucine

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ile Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Ile Asp Ala Ser Asn Arg Ala Thr Ile Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
                85                  90                  95      


Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  103
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  103
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  104
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  104

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  105
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  105
gatatcaaac tgcagcagtc aggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaaga cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  106
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  106

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  107
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  107
caggtgcagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt acagccttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  108
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  108

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  109
<211>  317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  109
gacattcagc tgacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gagccagttc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaagtgg cttctggagt cccttatcgc      180

ttcagtggca gtgggtctgg gacctcatac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaacagtgg agtagtaacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaa                                                     317


<210>  110
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  110

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  111
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  111
gatatcgtgc tcactcagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac      180

ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaac                                                    318


<210>  112
<211>  728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  112
gatatcaaac tgcagcagtc aggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaaga cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcagtc      360

gaaggtggaa gtggaggttc tggtggaagt ggaggttcag gtggagtcga cgacattcag      420

ctgacccagt ctccagcaat catgtctgca tctccagggg agaaggtcac catgacctgc      480

agagccagtt caagtgtaag ttacatgaac tggtaccagc agaagtcagg cacctccccc      540

aaaagatgga tttatgacac atccaaagtg gcttctggag tcccttatcg cttcagtggc      600

agtgggtctg ggacctcata ctctctcaca atcagcagca tggaggctga agatgctgcc      660

acttattact gccaacagtg gagtagtaac ccgctcacgt tcggtgctgg gaccaagctg      720

gagctgaa                                                               728


<210>  113
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  113

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu 
        


<210>  114
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  114

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Tyr Tyr Tyr Asp Phe Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  115
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  115
gaggtccagc tggtacagtc tggagcagag gtgaaaaagc ccggggagtc tctgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg acccgggaca cgtccacgag cacagtctac      240

atggagctta gcagcctgag atctgaggac acggccgtgt attactgtgc tagaggtagt      300

gcttattact acgattttgc tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  116
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  116

Gln Pro Val Leu Thr Gln Pro Ser Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly His Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Tyr Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  117
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  117
cagcctgtgc tgactcagcc atcctcggtg tcagtggccc caggacagac ggccacgatc       60

tcctgtgggg gacacaacat tgggagtaaa aatgtgcact ggtaccagca gaggccaggc      120

cagtcccctg tgttggtcat ttatcaggat aataagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggcgatg      240

gatgaggctg actactattg tcaggtgtgg gacaattaca gtgtgctatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  118
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  118

Asp Ile Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro 
1               5                   10                  15      


Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Asn Thr Gly Thr Val Thr 
            20                  25                  30          


Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe 
        35                  40                  45              


Thr Gly Leu Ile Gly His Thr Asn Asn Arg Ala Pro Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr 
65                  70                  75                  80  


Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr 
                85                  90                  95      


Asn Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  119
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  119
gatatccagc tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      120

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      180

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggaga aggtggatgc tgcaacctat cactgtcagc aaagtactga ggatccgtgg      300

acgttcggtg gagggaccaa gctcgagatc aaa                                   333


<210>  120
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  120

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Val Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Trp Tyr Phe Asp Val Trp Gly Ala Arg Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  121
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  121
caggtgcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttggcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtaa agccactctg actgcagacg aatcctccag cacagcctac      240

atgcaactca gcagcctagc atctgaggac tctgcggtct atttctgtgc aagacgggag      300

actacgacgg taggccgtta ttactatgct atggactact ggggccaagg gaccacggtc      360

accgtctcct ccg                                                         373


<210>  122
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anntibody sequence

<400>  122

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 
                165                 170                 175     


Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250 


<210>  123
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  123
gatatccagc tgacccagtc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      120

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      180

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggaga aggtggatgc tgcaacctat cactgtcagc aaagtactga ggatccgtgg      300

acgttcggtg gagggaccaa gctcgagatc aaaggtggtg gtggttctgg cggcggcggc      360

tccggtggtg gtggttctca ggtgcagctg cagcagtctg gggctgagct ggtgaggcct      420

gggtcctcag tgaagatttc ctgcaaggct tctggctatg cattcagtag ctactggatg      480

aactgggtga agcagaggcc tggacagggt cttgagtgga ttggacagat ttggcctgga      540

gatggtgata ctaactacaa tggaaagttc aagggtaaag ccactctgac tgcagacgaa      600

tcctccagca cagcctacat gcaactcagc agcctagcat ctgaggactc tgcggtctat      660

ttctgtgcaa gacgggagac tacgacggta ggccgttatt actatgctat ggactactgg      720

ggccaaggga ccacggtcac cgtctcctcc                                       750


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  124

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  125
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  125

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Lys Val 
    210                 215                 220                 


Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu Asp Pro Trp Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 250 


<210>  126
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  126
caggtgcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttggcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtaa agccactctg actgcagacg aatcctccag cacagcctac      240

atgcaactca gcagcctagc atctgaggac tctgcggtct atttctgtgc aagacgggag      300

actacgacgg taggccgtta ttactatgct atggactact ggggccaagg gaccacggtc      360

accgtctcct ccggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttctgat      420

atccagctga cccagtctcc agcttctttg gctgtgtctc tagggcagag ggccaccatc      480

tcctgcaagg ccagccaaag tgttgattat gatggtgata gttatttgaa ctggtaccaa      540

cagattccag gacagccacc caaactcctc atctatgatg catccaatct agtttctggg      600

atcccaccca ggtttagtgg cagtgggtct gggacagact tcaccctcaa catccatcct      660

gtggagaagg tggatgctgc aacctatcac tgtcagcaaa gtactgagga tccgtggacg      720

ttcggtggag ggaccaagct cgagatcaaa                                       750


<210>  127
<211>  1121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  127
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgatat ccagctgacc       60

cagtctccag cttctttggc tgtgtctcta gggcagaggg ccaccatctc ctgcaaggcc      120

agccaaagtg ttgattatga tggtgatagt tatttgaact ggtaccaaca gattccagga      180

cagccaccca aactcctcat ctatgatgca tccaatctag tttctgggat cccacccagg      240

tttagtggca gtgggtctgg gacagacttc accctcaaca tccatcctgt ggagaaggtg      300

gatgctgcaa cctatcactg tcagcaaagt actgaggatc cgtggacgtt cggtggaggg      360

accaagctcg agatcaaagg aggtggtgga tccgatatca aactgcagca gtcaggggct      420

gaactggcaa gacctggggc ctcagtgaag atgtcctgca agacttctgg ctacaccttt      480

actaggtaca cgatgcactg ggtaaaacag aggcctggac agggtctgga atggattgga      540

tacattaatc ctagccgtgg ttatactaat tacaatcaga agttcaagga caaggccaca      600

ttgactacag acaaatcctc cagcacagcc tacatgcaac tgagcagcct gacatctgag      660

gactctgcag tctattactg tgcaagatat tatgatgatc attactgcct tgactactgg      720

ggccaaggca ccactctcac agtctcctca gtcgaaggtg gaagtggagg ttctggtgga      780

agtggaggtt caggtggagt cgacgacatt cagctgaccc agtctccagc aatcatgtct      840

gcatctccag gggagaaggt caccatgacc tgcagagcca gttcaagtgt aagttacatg      900

aactggtacc agcagaagtc aggcacctcc cccaaaagat ggatttatga cacatccaaa      960

gtggcttctg gagtccctta tcgcttcagt ggcagtgggt ctgggacctc atactctctc     1020

acaatcagca gcatggaggc tgaagatgct gccacttatt actgccaaca gtggagtagt     1080

aacccgctca cgttcggtgc tgggaccaag ctggagctga a                         1121


<210>  128
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  128

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
1               5                   10                  15      


Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
            20                  25                  30          


Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly 
        35                  40                  45              


Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
                85                  90                  95      


Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr Glu 
            100                 105                 110         


Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
                165                 170                 175     


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly 
                245                 250                 255     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu 
            260                 265                 270         


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
        275                 280                 285             


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
305                 310                 315                 320 


Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly 
        355                 360                 365             


Thr Lys Leu Glu Leu 
    370             


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  130
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  130
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttct                       45


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  131

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  132
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  132
tccggaggtg gtggatcc                                                     18


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  133

Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Val Asp 
        


<210>  134
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  134
gtcgaaggtg gaagtggagg ttctggtgga agtggaggtt caggtggagt cgac             54


<210>  135
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Lys 
            100                 105                 110 


<210>  136
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  136
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaacgtaag                                       330


<210>  137
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  137

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  138
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  138
gatatcaaac tgcagcagtc aggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaaga cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  139
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  139

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  140
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  140
gacattcagc tgacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gagccagttc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaagtgg cttctggagt cccttatcgc      180

ttcagtggca gtgggtctgg gacctcatac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaacagtgg agtagtaacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


