                         SEQUENCE LISTING

<110>  Technion Research and Development Foundation Ltd.
       Carmel-Haifa University Economic Corporation Ltd.
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF 
       NEURODEGENERATIVE DISORDERS

<130>  2221438

<150>  US61/649,311
<151>  2012-05-20

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser 
    130                 135                 140                 


Leu Phe Leu Thr Asp Leu Tyr Arg Asp Arg Lys Leu Leu Gly Ala Glu 
145                 150                 155                 160 


Glu Arg Ile Met Gln Thr Val Glu Ile Thr Lys His Ala Val Asp Ile 
                165                 170                 175     


Glu Glu Lys Gly Val Arg Leu Arg Leu Thr Ile Val Asp Thr Pro Gly 
            180                 185                 190         


Phe Gly Asp Ala Val Asn Asn Thr Glu Cys Trp Lys Pro Val Ala Glu 
        195                 200                 205             


Tyr Ile Asp Gln Gln Phe Glu Gln Tyr Phe Arg Asp Glu Ser Gly Leu 
    210                 215                 220                 


Asn Arg Lys Asn Ile Gln Asp Asn Arg Val His Cys Cys Leu Tyr Phe 
225                 230                 235                 240 


Ile Ser Pro Phe Gly His Gly Tyr Gly Pro Ser Leu Arg Leu Leu Ala 
                245                 250                 255     


Pro Pro Gly Ala Val Lys Gly Thr Gly Gln Glu His Gln Gly Gln Gly 
            260                 265                 270         


Cys His 
        


<210>  2
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  2
cggcggtgct gcgaggtcgg cgcgcacgtc cgccgcgggt cgctcgggcg ctgtccaggc       60

ggagccggcc ccgcccgggc tgcagccatg atcaagcgtt tcctggagga caccacggat      120

gatggagaac tgagcaagtt cgtgaaggat ttctcaggaa atgcgagctg ccacccacca      180

gaggctaaga cctgggcatc caggccccaa gtcccggagc caaggcccca ggccccggac      240

ctctatgatg atgacctgga gttcagaccc ccctcgcggc cccagtcctc tgacaaccag      300

cagtacttct gtgccccagc ccctctcagc ccatctgcca ggccccgcag cccatggggc      360

aagcttgatc cctatgattc ctctgaggat gacaaggagt atgtgggctt tgcaaccctc      420

cccaaccaag tccaccgaaa gtccgtgaag aaaggctttg actttaccct catggtggca      480

ggagagtctg gcctgggcaa atccacactt gtcaatagcc tcttcctcac tgatctgtac      540

cgggaccgga aacttcttgg tgctgaagag aggatcatgc aaactgtgga gatcactaag      600

catgcagtgg acatagaaga gaagggtgtg aggctgcggc tcaccattgt ggacacacca      660

ggttttgggg atgcagtcaa caacacagag tgctggaagc ctgtggcaga atacattgat      720

cagcagtttg agcagtattt ccgagacgag agtggcctga accgaaagaa catccaagac      780

aacagggtgc actgctgcct gtacttcatc tcacccttcg gccatgggta tggtccaagc      840

ctgaggctcc tggcaccacc gggtgctgtc aagggaacag gccaagagca ccaggggcag      900

ggctgccact agcaggtggt cacaggttcc tgttccccag gctccggcca ttggatgttg      960

aattcatgaa ggccctgcat cagcgggtca acatcgtgcc tatcctggct aaggcagaca     1020

cactgacacc tcccgaagtg gaccacaaga aacgcaaaat ccgggaggag attgagcatt     1080

ttggaatcaa gatctatcaa ttcccagact gtgactctga tgaggatgag gacttcaaat     1140

tgcaggacca agccctaaag gaaagcatcc catttgcagt aattggcagc aacactgtag     1200

tagaggccag agggcggcga gttcggggtc gactctaccc ctggggcatc gtggaagtgg     1260

aaaacccagg gcactgcgac tttgtgaagc tgaggacaat gctggtacgt acccacatgc     1320

aggacctgaa ggatgtgaca cgggagacac attatgagaa ctaccgggca cagtgcatcc     1380

agagcatgac ccgcctggtg gtgaaggaac ggaatcgcaa gtatgaccag aagccaggac     1440

aaagctggca gggggagatc ccaagcctag ccttgggtga gaccaagccc tacttttgtt     1500

cttctatagg ccctgggctc aatctaagcg ggtgctgggg tcctcctcgc cttatcaacc     1560

cttttctccc tttagcaaac tgactcggga aagtggtacc gacttcccca tccctgctgt     1620

cccaccaggg acagatccag aaactgagaa gcttatccga gagaaagatg aggagctgcg     1680

gcggatgcag gagatgctac acaaaataca aaaacagatg aaggagaact attaactggc     1740

tttcagccct ggatatttaa atctcctcct cttcttcctg tccatgccgg cccctcccag     1800

caccagctct gctcaggccc cttcagctac tgccacttcg ccttacatcc ctgctgactg     1860

cccagagact cagaggaaat aaagtttaat aaatctgtag gtggctaaaa a              1911


<210>  3
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80  


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95      


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110         


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125             


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140                 


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160 


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175     


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190         


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205             


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Pro Val 
    210                 215                 220                 


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240 


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255     


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270         


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285             


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300                 


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320 


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335     


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350         


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365             


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380                 


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400 


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415     


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430         


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445             


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460                 


Val 
465 


<210>  4
<211>  2960
<212>  DNA
<213>  Homo sapiens

<400>  4
tccgggagga ttacccagga gaccgctggt gggaggcgcg gctggcgccg ctgcgcgcat       60

gggcctgttc ctggcccgca gccgccacct acccagtgac catgatagtg tttgtcaggt      120

tcaactccag ccatggtttc ccagtggagg tcgattctga caccagcatc ttccagctca      180

aggaggtggt tgctaagcga cagggggttc cggctgacca gttgcgtgtg attttcgcag      240

ggaaggagct gaggaatgac tggactgtgc agaattgtga cctggatcag cagagcattg      300

ttcacattgt gcagagaccg tggagaaaag gtcaagaaat gaatgcaact ggaggcgacg      360

accccagaaa cgcggcggga ggctgtgagc gggagcccca gagcttgact cgggtggacc      420

tcagcagctc agtcctccca ggagactctg tggggctggc tgtcattctg cacactgaca      480

gcaggaagga ctcaccacca gctggaagtc cagcaggtag atcaatctac aacagctttt      540

atgtgtattg caaaggcccc tgtcaaagag tgcagccggg aaaactcagg gtacagtgca      600

gcacctgcag gcaggcaacg ctcaccttga cccagggtcc atcttgctgg gatgatgttt      660

taattccaaa ccggatgagt ggtgaatgcc aatccccaca ctgccctggg actagtgcag      720

aatttttctt taaatgtgga gcacacccca cctctgacaa ggaaacacca gtagctttgc      780

acctgatcgc aacaaatagt cggaacatca cttgcattac gtgcacagac gtcaggagcc      840

ccgtcctggt tttccagtgc aactcccgcc acgtgatttg cttagactgt ttccacttat      900

actgtgtgac aagactcaat gatcggcagt ttgttcacga ccctcaactt ggctactccc      960

tgccttgtgt ggctggctgt cccaactcct tgattaaaga gctccatcac ttcaggattc     1020

tgggagaaga gcagtacaac cggtaccagc agtatggtgc agaggagtgt gtcctgcaga     1080

tggggggcgt gttatgcccc cgccctggct gtggagcggg gctgctgccg gagcctgacc     1140

agaggaaagt cacctgcgaa gggggcaatg gcctgggctg tgggtttgcc ttctgccggg     1200

aatgtaaaga agcgtaccat gaaggggagt gcagtgccgt atttgaagcc tcaggaacaa     1260

ctactcaggc ctacagagtc gatgaaagag ccgccgagca ggctcgttgg gaagcagcct     1320

ccaaagaaac catcaagaaa accaccaagc cctgtccccg ctgccatgta ccagtggaaa     1380

aaaatggagg ctgcatgcac atgaagtgtc cgcagcccca gtgcaggctc gagtggtgct     1440

ggaactgtgg ctgcgagtgg aaccgcgtct gcatggggga ccactggttc gacgtgtagc     1500

cagggcggcc gggcgcccca tcgccacatc ctgggggagc atacccagtg tctaccttca     1560

ttttctaatt ctcttttcaa acacacacac acacgcgcgc gcgcgcacac acactcttca     1620

agtttttttc aaagtccaac tacagccaaa ttgcagaaga aactcctgga tccctttcac     1680

tatgtccatg aaaaacagca gagtaaaatt acagaagaag ctcctgaatc cctttcagtt     1740

tgtccacaca agacagcaga gccatctgcg acaccaccaa caggcgttct cagcctccgg     1800

atgacacaaa taccagagca cagattcaag tgcaatccat gtatctgtat gggtcattct     1860

cacctgaatt cgagacaggc agaatcagta gctggagaga gagttctcac atttaatatc     1920

ctgcctttta ccttcagtaa acaccatgaa gatgccattg acaaggtgtt tctctgtaaa     1980

atgaactgca gtgggttctc caaactagat tcatggcttt aacagtaatg ttcttattta     2040

aattttcaga aagcatctat tcccaaagaa ccccaggcaa tagtcaaaaa catttgttta     2100

tccttaagaa ttccatctat ataaatcgca ttaatcgaaa taccaactat gtgtaaatca     2160

acttgtcaca aagtgagaaa ttatgaaagt taatttgaat gttgaatgtt tgaattacag     2220

ggaagaaatc aagttaatgt actttcattc cctttcatga tttgcaactt tagaaagaaa     2280

ttgtttttct gaaagtatca ccaaaaaatc tatagtttga ttctgagtat tcattttgca     2340

acttggagat tttgctaata catttggctc cactgtaaat ttaatagata aagtgcctat     2400

aaaggaaaca cgtttagaaa tgatttcaaa atgatattca atcttaacaa aagtgaacat     2460

tattaaatca gaatctttaa agaggagcct ttccagaact accaaaatga agacacgccc     2520

gactctctcc atcagaaggg tttatacccc tttggcacac cctctctgtc caatctgcaa     2580

gtcccaggga gctctgcata ccaggggttc cccaggagag accttctctt aggacagtaa     2640

actcactaga atattcctta tgttgacatg gattggattt cagttcaatc aaactttcag     2700

cttttttttc agccattcac aacacaatca aaagattaac aacactgcat gcggcaaacc     2760

gcatgctctt acccacacta cgcagaagag aaagtacaac cactatcttt tgttctacct     2820

gtattgtctg acttctcagg aagatcgtga acataactga gggcatgagt ctcactagca     2880

catggaggcc cttttggatt tagagactgt aaattattaa atcggcaaca gggcttctct     2940

ttttagatgt agcactgaaa                                                 2960


<210>  5
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


<210>  6
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser 
    130                 135                 140                 


Leu Phe Leu Thr 
145             


<210>  7
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu Gly 
            20                  25                  30          


Lys Ser Thr Leu Val Asn Ser Leu Phe Leu Thr 
        35                  40              


<210>  8
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu 
            20                  25              


<210>  9
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu 
            20              


<210>  10
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn 
            20                  25                  30          


Ser Leu Phe Leu Thr 
        35          


<210>  11
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu Met Val Ala Gly Glu 
            20          


<210>  12
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu 
    


<210>  13
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu Gly 
            20                  25                  30          


Lys Ser Thr 
        35  


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe 
1               5                   10                  15  


<210>  15
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  15
gagcaccagg ggcagggct                                                    19


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu His Gln Gly Gln Gly 
1               5       


<210>  17
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer (forward) for shRNA of ARTS

<400>  17
gatccccgag caccaggggc agggctttca agagaagccc tgcccctggt gctcttttta       60


<210>  18
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer (reverse) for shRNA of ARTS

<400>  18
agcttaaaaa gagcacaggg gcagggcttc tcttgaaagc cctgcccctg gtgctcggg        59


<210>  19
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  20
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile 
1               5                   10                  15      


Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Ala Leu 
            20                  25                  30          


Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu Thr 
        35                  40                  45              


Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His Ala Lys Trp Tyr 
    50                  55                  60                  


Pro Gly Cys Lys Tyr 
65                  


<210>  21
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Phe Gly Thr Trp 
1               5   


