                         SEQUENCE LISTING

<110>  Trustees of Boston University
       Lam, Stephen
 
<120>  A COPD-associated Bronchial Airway Epithelial Gene Expression 
       Signature That Reflects Disease Acitivty

<130>  1006.004-PCT

<150>  61649355
<151>  2012-05-20

<150>  61725391
<151>  2012-11-12

<160>  195   

<170>  PatentIn version 3.5

<210>  1
<211>  2499
<212>  DNA
<213>  Homo sapiens

<400>  1
gctgggcacc gttctgtttt ctttcttttc ttaatcctat ccaagtatgc agtacgctct       60

tgggtcgtct catgagaccc aggggcatgt tggaaagaac tgagagaaag agcaacaaag      120

cggcgagtgg tgtgagaggg cagcacgcgc tgtggggccc ttccagagaa atgtactgaa      180

aaagtctacg caatgtctgg gatttgctaa acaatacctg gaaagcagac aggtcttttt      240

gccattcctc caggacatcc accataagga aaggagaccc tggaccaaca ttctctaaga      300

tgtttatatg gaccagtggc cggacctctt catcttatag acatgatgaa aaaagaaata      360

tttaccagaa aatcagggac catgacctcc tggacaaaag gaaaacagtc acagcactga      420

aggcaggaga ggaccgagct attctcctgg gactggctat gatggtgtgc tccatcatga      480

tgtattttct gctgggaatc acactcctgc gctcatacat gcagagcgtg tggaccgaag      540

agtctcaatg caccttgctg aatgcgtcca tcacggaaac atttaattgc tccttcagct      600

gtggtccaga ctgctggaaa ctttctcagt acccctgcct ccaggtgtac gttaacctga      660

cttcttccgg ggaaaagctc ctcctctacc acacagaaga gacaataaaa atcaatcaga      720

agtgctccta tatacctaaa tgtggaaaaa attttgaaga atccatgtcc ctggtgaatg      780

ttgtcatgga aaacttcagg aagtatcaac acttctcctg ctattctgac ccagaaggaa      840

accagaagag tgttatccta acaaaactct acagttccaa cgtgctgttc cattcactct      900

tctggccaac ctgtatgatg gctgggggtg tggcaattgt tgccatggtg aaacttacac      960

agtacctctc cctactatgt gagaggatcc aacggatcaa tagataaatg caaaaatgga     1020

taaaataatt tttgttaaag ctcaaatact gttttctttc attcttcacc aaagaacctt     1080

aagtttgtaa cgtgcagtct gttatgagtt ccctaatata ttcttatatg tagagcaata     1140

atgcaaaagc tgttctatat gcaaacatga tgtctttatt attcaggaga ataaataact     1200

gttttgtgtt ggttggtggt tttcataatc ttatttctgt actggaacta gtactttctt     1260

ctctcattcc gccaaaacag ggctcagtta ttcatttgcc aagcttcgtg gaggaatgta     1320

ggtgacatca atgtgataaa gtctgtgttc tgagttgtca gatctcttga agacaatatt     1380

tttcatcact tattgtttac taaagctaca gccaaaaata tttttttttc ttattctaaa     1440

ctgagcccta tagcaagtga agggaccaga tttcctaatt aaaggaagtt aggtactttt     1500

cttgtatttt ttaccatatc actgtaaaga agaggggaaa cccagccagc tacttttttt     1560

catcactttt tattcataac ttcagatttg taaaactaat ttccaaaata taagctgttt     1620

tcattagcca gttctataat atcttcctgt gatttatgta gaaaatgaac acaccccttt     1680

tccatttaag accctgctac tgtgtgaaga gatgatactt acaaggagtg tcattacctg     1740

tgagctgact gaatgttggt aggtgctcca ttacaatcca ggaaagtctg tgttactgat     1800

atttgtgtgg aaatctttat ttcacttcaa tttaaccatt agatggtaaa attaagatgc     1860

tacttgttgg taaaaattgg tggactggtt tcaatgggta aatgtgttgt ggcaaattaa     1920

tgtgttggaa tattgctctt tgtgaatttg tgcttaagtc aatgaatgtg tagtatctcc     1980

ttctgacaag cattccctat tgggatttta aagctatgtg cacagaatat tagtctcttc     2040

tacatgtttt atttttctat ttataattcc cttttttgtt gttatatttt atacacagaa     2100

tagatctttt ttctaacaca tatttgaact gaataacaga cttaaagaaa gcctttgttc     2160

acattgctat ttacttttgt gtttggggga aaatacgagg gattgatttt aaataaaaaa     2220

cattccatct ttcatttaat atcaatatca aaagaagaag acaaacatct atctttctca     2280

tctatattta agtacctttt tgtaatgtag tatcaaagtt ttttaggtaa tgcaaaattt     2340

tacaaatcat ttgtggaatg aatggtaaaa ctaatctgat gaaatggaaa attattctgc     2400

aatattgtaa ttcatagttt gacttttcat aagcaaataa atccctagga tgtaatcagg     2460

acttcaaatg tgtaattaaa tttttttaaa aaaaatcta                            2499


<210>  2
<211>  2231
<212>  DNA
<213>  Homo sapiens

<400>  2
aaaacaggaa ataggtgttt catatatacg gctctaacct tctctctctg caccttcctt       60

ctgtcaatag atgaaacaaa tacttcatcc tgctctggaa accactgatc cctgttccac      120

cggttttgtt ttcccagcaa tgacattatt cccagtgctg ttgttcctgg ttgctgggct      180

gcttccatct tttccagcaa atgaagataa ggatcccgct tttactgctt tgttaaccac      240

ccaaacacaa gtgcaaaggg agattgtgaa taagcacaat gaactgagga gagcagtatc      300

tccccctgcc agaaacatgc tgaagatgga atggaacaaa gaggctgcag caaatgccca      360

aaagtgggca aaccagtgca attacagaca cagtaaccca aaggatcgaa tgacaagtct      420

aaaatgtggt gagaatctct acatgtcaag tgcctccagc tcatggtcac aagcaatcca      480

aagctggttt gatgagtaca atgattttga ctttggtgta gggccaaaga ctcccaacgc      540

agtggttgga cattatacac aggttgtttg gtactcttca tacctcgttg gatgtggaaa      600

tgcctactgt cccaatcaaa aagttctaaa atactactat gtttgccaat attgtcctgc      660

tggtaattgg gctaatagac tatatgtccc ttatgaacaa ggagcacctt gtgccagttg      720

cccagataac tgtgacgatg gactatgcac caatggttgc aagtacgaag atctctatag      780

taactgtaaa agtttgaagc tcacattaac ctgtaaacat cagttggtca gggacagttg      840

caaggcctcc tgcaattgtt caaacagcat ttattaaata cgcattacac accgagtagg      900

gctatgtaga gaggagtcag attatctact tagatttggc atctacttag atttaacata      960

tactagctga gaaattgtag gcatgtttga tacacatttg atttcaaatg tttttcttct     1020

ggatctgctt tttattttac aaaaatattt ttcatacaaa tggttaaaaa gaaacaaaat     1080

ctataacaac aactttggat ttttatatat aaactttgtg atttaaattt actgaattta     1140

attagggtga aaattttgaa agttgtattc tcatatgact aagttcacta aaaccctgga     1200

ttgaaagtga aaattatgtt cctagaacaa aatgtacaaa aagaacaata taattttcac     1260

atgaaccctt ggctgtagtt gcctttccta gctccactct aaggctaagc atcttcaaag     1320

acgttttccc atatgctgtc ttaattcttt tcactcattc acccttcttc ccaatcatct     1380

ggctggcatc ctcacaattg agttgaagct gttcctccta aaacaatcct gacttttatt     1440

ttgccaaaat caatacaatc ctttgaattt tttatctgca taaattttac agtagaatat     1500

gatcaaacct tcatttttaa acctctcttc tctttgacaa aacttcctta aaaaagaata     1560

caagataata taggtaaata ccctccactc aaggaggtag aactcagtcc tctcccttgt     1620

gagtcttcac taaaatcagt gactcacttc caaagagtgg agtatggaaa gggaaacata     1680

gtaactttac aggggagaaa aatgacaaat gacgtcttca ccaagtgatc aaaattaacg     1740

tcaccagtga taagtcattc agatttgttc tagataatct ttctaaaaat tcataatccc     1800

aatctaatta tgagctaaaa catccagcaa actcaagttg aaggacattc tacaaaatat     1860

ccctggggta ttttagagta ttcctcaaaa ctgtaaaaat catggaaaat aagggaatcc     1920

tgagaaacaa tcacagacca catgagacta aggagacatg tgagccaaat gcaatgtgct     1980

tcttggatca gatcctggaa cagaaaaaga tcagtaatga aaaaactgat gaagtctgaa     2040

tagaatctgg agtattttta acagtagtgt tgatttctta atcttgataa atatagcagg     2100

gtaatgtaag atgataacgt tagagaaact gaaactgggt gagggctatc taggaattct     2160

ctgtactatc ttaccaaatt ttcggtaagt ctaagaaagc aatgcaaaat aaaaagtgtc     2220

ttgaaaaaaa a                                                          2231


<210>  3
<211>  3578
<212>  DNA
<213>  Homo sapiens

<400>  3
cgggccctct ccctctctcc ctttcttcct gcctcgcctt cctgcggcga aggaggctca       60

tctattataa atgcacattc ggggctgaca tcagcgacga gcggcgggcg agcgccgacg      120

agcggtccct gcgcgctgcc cgcccggagc gcagccccca ggctcggccg agccgccggc      180

ggggcgcggg gagcgagccg ggagctgccg gacccccttc cgccgccgcc ccgggccgcc      240

gccgccgccc ccgcacgccg cgcccgcgcc cccgctccgc cgcggagttt ctgcatgact      300

gtcacaaaga tgtcctggcg tccgcaatac cgtagctcca agttccggaa tgtctacggg      360

aaggtggcca accgggagca ctgcttcgat gggatcccca tcaccaagaa tgtgcacgac      420

aaccacttct gtgccgtcaa cacccgcttc ctggccatcg tcaccgagag cgcagggggc      480

ggctccttcc tcgtcatccc cctggagcag acaggcagga ttgaacccaa ctaccccaag      540

gtctgcggcc accagggcaa tgtgctggat atcaaatgga accccttcat cgacaacatc      600

attgcctcgt gctcggagga cacgtcggtg cggatctggg agatccccga gggcgggctg      660

aagcggaaca tgacggaggc gctcctggag ctgcacgggc acagccggcg tgtggggctg      720

gtcgagtggc accccaccac caacaacatc ctgttcagcg ctggctacga ctacaaggtc      780

ctcatctgga acctggatgt gggtgagccg gtgaagatga ttgactgcca cacggatgtg      840

atcctctgca tgtccttcaa cacggacggc agcctgctca ccaccacgtg caaggacaag      900

aagctgcgtg tgattgagcc ccgctctggc cgtgttctgc aggaggccaa ctgcaaaaac      960

cacagagtga accgggtggt gttcctgggg aacatgaagc ggctcctcac gacaggggtc     1020

tccaggtgga acacaagaca gattgccctc tgggaccagg aggacctctc catgcccctg     1080

atcgaagagg aaattgatgg gctctctggc ctcctgttcc ccttctatga tgctgacacc     1140

cacatgctct acctggctgg aaagggtgat ggaaacatcc ggtactacga gatcagcact     1200

gagaagccct acctgagtta cctcatggag ttccgctccc cagccccgca gaaaggccta     1260

ggggtcatgc ccaagcacgg gctggatgtg tcagcctgcg aggtgttccg cttctacaag     1320

ctggtgactc tcaagggcct gatcgagccc atctccatga tcgtgccccg gaggtcagat     1380

tcctaccagg aagacattta cccaatgaca ccaggcacgg agccagcact gaccccggat     1440

gaatggctgg gaggcatcaa ccgagatccc gtgctgatgt ctttgaaaga aggctataag     1500

aagtcctcaa aaatggtatt taaggctccc atcaaagaaa agaagagtgt tgtggtcaac     1560

ggaatagatt tattagaaaa tgtcccaccc aggacagaga atgagctcct tcgaatgttc     1620

ttccggcagc aggatgagat tcgacggttg aaagaggagc tggcccagaa ggacatccgc     1680

attcggcagc tccagctgga actgaaaaac ttgcgcaaca gccccaagaa ctgttagctc     1740

cccagctggg ctgttttcta agccgatctc tccgtcgttt ctactcatcc cttaacttct     1800

cccttaccag tgaccccaga gacagagcca ggacaggagt gggggccagc ctgaggaccc     1860

ccgcctacca cctcgagaac tggaagccaa cctctaacct cctgacctca tgctaataaa     1920

agtccccagc ttctggagac cccctgccgg cagccccttt ccctgccacc ccaggagcca     1980

ggcttcccct cagctgggtg aagactacag actccctggg gttggcaggg gctccatctc     2040

agtggaccag gaagcaagag gggaagcggg atcccagcta gacttagaac ttggactttt     2100

cccctgtgaa gggggctgcc aggacatctc agcactcccg cctggagctc tcagcatcac     2160

tgaaggtacc acagtgtaag tgctggactg caggctgcag tgatccctct ttcgtcccac     2220

cccctcttcc ctcagcagcc ccggaagcct gcctcacccg acgaggacag cgagcggccc     2280

ggctcctttc tgtctcttcc cttcccaccc tcttgtcttc agggaattca gaggattgct     2340

ctccaaggcc ataatgaccc cttgccttcc ccatgattct ctacaaagct cttgcacacc     2400

cttttcccat tcaatttgtg agccaggcag ggtagggatt agtgtccccc tttgacaaat     2460

gacagaactg agggttgcaa tggggaaatg acttataaag tcacccagca ggtcaacaat     2520

gggcccacga ccaagaccct gggtgttcag accccaaggc cagggccttt cccgctgcat     2580

caagatgcca atccctttgt gggcttcacc agtgcccaag tctctatgga gaatgagaac     2640

tggaagccac tgctaccgtc tacccagcac cagtagtgcc gatgtgccac actgcccagt     2700

tgaggcccct cacgctctgt gcccctagat ccttcaggtc cccaccctca gctgtcacca     2760

ccaccctccc caggggactc catctgagat gaggcctcgt cctcctggaa gctgaggctg     2820

agaagggtgg agcttggccc tggggaaggc agaccagggt ctgatggctt ctagggatgc     2880

tctgcgtgtg tctcagcacc gctatctcag ccactttcag ccttatgcac gtagaatgac     2940

cacagccact cgcatccgta tagcacttta aagtttctgc agtcctttga cacataggat     3000

ctcatggagc ctcacgtcta ctcccttctg cagatgagga aaccgagaga agtggcccaa     3060

ggtcacgcaa ctctgagatg ccacatttca tttgatcttg tacacatttt cttttattcc     3120

ttcttttttc ctcctttcat ttcccactac gcacaaagag tttataaaca ctgttctcag     3180

aagagtcaca gtttggggtg agatctggaa atcaagaaat gggtgtccac tcttttcttt     3240

cattagctag gatctactag atgcattata ctccatacct gcttttccca tggccgccct     3300

acggaaaatc ccatccacag aggccagggc tacccaagcc cctccaggtg agctgggcct     3360

ttcctttatg aacctccatc ctcccagcca gctacagtag ggcctcctca ccccgtaccc     3420

cacagctaga cagtgtcagc actcatctcc tcctcccaca tttctggagc tttttttttt     3480

ccttccccat tgacctttgt ggtcttctgt gattatttat gctgcctccc aaggatagaa     3540

ttgaaataaa atgttttcaa cttatcaaaa aaaaaaaa                             3578


<210>  4
<211>  1952
<212>  DNA
<213>  Homo sapiens

<400>  4
gtgtttaggg tgttggcgga gacaaagggg aagagtcatc gcctgtcggg gctaggatat       60

gatgggtgag aggtgtcaaa ccaaattctc tcggtttgga aacggagaaa atctaaaaat      120

gaggatgtga ggaaagagtc cgctctcaag gcgcgttgtg gtctatccga gccccgtccc      180

ctgggctccc tcgggctggg gtgaggcggg cagcgctacg cgtggggtag gaccatctta      240

cgctgggacc ccgccaagga gccccaggaa gtaggtgaaa gggcaggggc gtggctctcg      300

gggcgccacc cacgctcttg aaatctgggt gattgcgagc ggccgctcag cgtcccccac      360

accacagacc cgcgccgccg acgacccagc agccgccatg gctctgctcc gaggtgtgtt      420

tgtagttgct gctaagcgaa cgccctttgg agcttacgga ggccttctga aagacttcac      480

tgctactgac ttgtctgaat ttgctgccaa ggctgccttg tctgctggca aagtctcacc      540

tgaaacagtt gacagtgtga ttatgggcaa tgtcctgcag agttcttcag atgctatata      600

tttggcaagg catgttggtt tgcgtgtggg aatcccaaag gagaccccag ctctcacgat      660

taataggctc tgtggttctg gttttcagtc cattgtgaat ggatgtcagg aaatttgtgt      720

taaagaagct gaagttgttt tatgtggagg aaccgaaagc atgagccaag ctccctactg      780

tgtcagaaat gtgcgttttg gaaccaagct tggatcagat atcaagctgg aagattcttt      840

atgggtatca ttaacagatc agcatgtcca gctccccatg gcaatgactg cagagaatct      900

tgctgtaaaa cacaaaataa gcagagaaga atgtgacaaa tatgccctgc agtcacagca      960

gagatggaaa gctgctaatg atgctggcta ctttaatgat gaaatggcac caattgaagt     1020

gaagacaaag aaaggaaaac agacaatgca ggtagacgag catgctcggc cccaaaccac     1080

cctggaacag ttacagaaac ttcctccagt attcaagaaa gatggaactg ttactgcagg     1140

gaatgcatcg ggtgtagctg atggtgctgg agctgttatc atagctagtg aagatgctgt     1200

taagaaacat aacttcacac cactggcaag aattgtgggc tactttgtat ctggatgtga     1260

tccctctatc atgggtattg gtcctgtccc tgctatcagt ggggcactga agaaagcagg     1320

actgagtctt aaggacatgg atttggtaga ggtgaatgaa gcttttgctc cccagtactt     1380

ggctgttgag aggagtttgg atcttgacat aagtaaaacc aatgtgaatg gaggagccat     1440

tgctttgggt cacccactgg gaggatctgg atcaagaatt actgcacacc tggttcacga     1500

attaaggcgt cgaggtggaa aatatgccgt tggatcagct tgcattggag gtggccaagg     1560

tattgctgtc atcattcaga gcacagcctg aagagaccag tgagctcact gtgacccatc     1620

cttactctac ttggccaggc cacagtaaaa caagtgacct tcagagcagc tgccacaact     1680

ggccatgccc tgccattgaa acagtgatta agtttgatca agccatggtg acacaaaaat     1740

gcattgatca tgaataggag cccatgctag aagtacattc tctcagattt gaaccagtga     1800

aatatgatgt atttctgagc taaaactcaa ctatagaaga cattaaaaga aatcgtattc     1860

ttgccaagta accaccactt ctgccttaga taatatgatt ataaggaaat caaataaatg     1920

ttgccttaac ttcaaaaaaa aaaaaaaaaa aa                                   1952


<210>  5
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  5
acccccgagc ccccgcagcc ctagagccgc ccaagggatg gcgatggcgt acttggcttg       60

gagactggcg cggcgttcgt gtccgaggtc actagtttcc cggtagttca gctgcacatg      120

aatagaacag caatgagagc cagtcagaag gactttgaaa attcaatgaa tcaagtgaaa      180

ctcttgaaaa aggatccagg aaacgaagtg aagctaaaac tctacgcgct atataagcag      240

gccactgaag gaccttgtaa catgcccaaa ccaggtgtat ttgacttgat caacaaggcc      300

aaatgggacg catggaatgc ccttggcagc ctgcccaagg aagctgccag gcagaactat      360

gtggatttgg tgtccagttt gagtccttca ttggaatcct ctagtcaggt ggagcctgga      420

acagacagga aatcaactgg gtttgaaact ctggtggtga cctccgaaga tggcatcaca      480

aagatcatgt tcaaccggcc caaaaagaaa aatgccataa acactgagat gtatcatgaa      540

attatgcgtg cacttaaagc tgccagcaag gatgactcaa tcatcactgt tttaacagga      600

aatggtgact attacagtag tgggaatgat ctgactaact tcactgatat tccccctggt      660

ggagtagagg agaaagctaa aaataatgcc gttttactga gggaatttgt gggctgtttt      720

atagattttc ctaagcctct gattgcagtg gtcaatggtc cagctgtggg catctccgtc      780

accctccttg ggctattcga tgccgtgtat gcatctgaca gggcaacatt tcatacacca      840

tttagtcacc taggccaaag tccggaagga tgctcctctt acacttttcc gaagataatg      900

agcccagcca aggcaacaga gatgcttatt tttggaaaga agttaacagc gggagaggca      960

tgtgctcaag gacttgttac tgaagttttc cctgatagca cttttcagaa agaagtctgg     1020

accaggctga aggcatttgc aaagcttccc ccaaatgcct tgagaatttc aaaagaggta     1080

atcaggaaaa gagagagaga aaaactacac gctgttaatg ctgaagaatg caatgtcctt     1140

cagggaagat ggctatcaga tgaatgcaca aatgctgtgg tgaacttctt atccagaaaa     1200

tcaaaactgt gatgaccact acagcagagt aaagcatgtc caaggaagga tgtgctgtta     1260

cctctgattt ccagtactgg aactaaataa gcttcattgt gccttttgta gtgctagaat     1320

atcaattaca atgatgatat ttcactacag ctctgatgaa taaaaagttt tgtaaaacaa     1380

gcttaagaat tcaaaaaaaa aaaaaaaaaa                                      1410


<210>  6
<211>  3600
<212>  DNA
<213>  Homo sapiens

<400>  6
gaagagactc agggcagagg gaggaaggac agcagaccag acagtcacag cagccttgac       60

aaaacgttcc tggaactcaa gctcttctcc acagaggagg acagagcaga cagcagagac      120

catggagtct ccctcggccc ctccccacag atggtgcatc ccctggcaga ggctcctgct      180

cacagcctca cttctaacct tctggaaccc gcccaccact gccaagctca ctattgaatc      240

cacgccgttc aatgtcgcag aggggaagga ggtgcttcta cttgtccaca atctgcccca      300

gcatcttttt ggctacagct ggtacaaagg tgaaagagtg gatggcaacc gtcaaattat      360

aggatatgta ataggaactc aacaagctac cccagggccc gcatacagtg gtcgagagat      420

aatatacccc aatgcatccc tgctgatcca gaacatcatc cagaatgaca caggattcta      480

caccctacac gtcataaagt cagatcttgt gaatgaagaa gcaactggcc agttccgggt      540

atacccggag ctgcccaagc cctccatctc cagcaacaac tccaaacccg tggaggacaa      600

ggatgctgtg gccttcacct gtgaacctga gactcaggac gcaacctacc tgtggtgggt      660

aaacaatcag agcctcccgg tcagtcccag gctgcagctg tccaatggca acaggaccct      720

cactctattc aatgtcacaa gaaatgacac agcaagctac aaatgtgaaa cccagaaccc      780

agtgagtgcc aggcgcagtg attcagtcat cctgaatgtc ctctatggcc cggatgcccc      840

caccatttcc cctctaaaca catcttacag atcaggggaa aatctgaacc tctcctgcca      900

cgcagcctct aacccacctg cacagtactc ttggtttgtc aatgggactt tccagcaatc      960

cacccaagag ctctttatcc ccaacatcac tgtgaataat agtggatcct atacgtgcca     1020

agcccataac tcagacactg gcctcaatag gaccacagtc acgacgatca cagtctatgc     1080

agagccaccc aaacccttca tcaccagcaa caactccaac cccgtggagg atgaggatgc     1140

tgtagcctta acctgtgaac ctgagattca gaacacaacc tacctgtggt gggtaaataa     1200

tcagagcctc ccggtcagtc ccaggctgca gctgtccaat gacaacagga ccctcactct     1260

actcagtgtc acaaggaatg atgtaggacc ctatgagtgt ggaatccaga acaaattaag     1320

tgttgaccac agcgacccag tcatcctgaa tgtcctctat ggcccagacg accccaccat     1380

ttccccctca tacacctatt accgtccagg ggtgaacctc agcctctcct gccatgcagc     1440

ctctaaccca cctgcacagt attcttggct gattgatggg aacatccagc aacacacaca     1500

agagctcttt atctccaaca tcactgagaa gaacagcgga ctctatacct gccaggccaa     1560

taactcagcc agtggccaca gcaggactac agtcaagaca atcacagtct ctgcggagct     1620

gcccaagccc tccatctcca gcaacaactc caaacccgtg gaggacaagg atgctgtggc     1680

cttcacctgt gaacctgagg ctcagaacac aacctacctg tggtgggtaa atggtcagag     1740

cctcccagtc agtcccaggc tgcagctgtc caatggcaac aggaccctca ctctattcaa     1800

tgtcacaaga aatgacgcaa gagcctatgt atgtggaatc cagaactcag tgagtgcaaa     1860

ccgcagtgac ccagtcaccc tggatgtcct ctatgggccg gacaccccca tcatttcccc     1920

cccagactcg tcttaccttt cgggagcgaa cctcaacctc tcctgccact cggcctctaa     1980

cccatccccg cagtattctt ggcgtatcaa tgggataccg cagcaacaca cacaagttct     2040

ctttatcgcc aaaatcacgc caaataataa cgggacctat gcctgttttg tctctaactt     2100

ggctactggc cgcaataatt ccatagtcaa gagcatcaca gtctctgcat ctggaacttc     2160

tcctggtctc tcagctgggg ccactgtcgg catcatgatt ggagtgctgg ttggggttgc     2220

tctgatatag cagccctggt gtagtttctt catttcagga agactgacag ttgttttgct     2280

tcttccttaa agcatttgca acagctacag tctaaaattg cttctttacc aaggatattt     2340

acagaaaaga ctctgaccag agatcgagac catcctagcc aacatcgtga aaccccatct     2400

ctactaaaaa tacaaaaatg agctgggctt ggtggcgcgc acctgtagtc ccagttactc     2460

gggaggctga ggcaggagaa tcgcttgaac ccgggaggtg gagattgcag tgagcccaga     2520

tcgcaccact gcactccagt ctggcaacag agcaagactc catctcaaaa agaaaagaaa     2580

agaagactct gacctgtact cttgaataca agtttctgat accactgcac tgtctgagaa     2640

tttccaaaac tttaatgaac taactgacag cttcatgaaa ctgtccacca agatcaagca     2700

gagaaaataa ttaatttcat gggactaaat gaactaatga ggataatatt ttcataattt     2760

tttatttgaa attttgctga ttctttaaat gtcttgtttc ccagatttca ggaaactttt     2820

tttcttttaa gctatccaca gcttacagca atttgataaa atatactttt gtgaacaaaa     2880

attgagacat ttacattttc tccctatgtg gtcgctccag acttgggaaa ctattcatga     2940

atatttatat tgtatggtaa tatagttatt gcacaagttc aataaaaatc tgctctttgt     3000

atgacagaat acatttgaaa acattggtta tattaccaag actttgacta gaatgtcgta     3060

tttgaggata taaacccata ggtaataaac ccacaggtac tacaaacaaa gtctgaagtc     3120

agccttggtt tggcttccta gtgtcaatta aacttctaaa agtttaatct gagattcctt     3180

ataaaaactt ccagcaaagc aactttaaaa aagtctgtgt gggccgggcg cggtggctca     3240

cgcctgtaat cccagcactt tgatccgccg aggcgggcgg atcacgaggt caggagatcc     3300

agaccatcct ggctaacaca gtgaaacccc gtctctacta aaaatacaaa aaaagttagc     3360

cgggcgtggt ggtgggggcc tgtagtccca gctactcagg aggctgaggc aggagaacgg     3420

catgaacccg ggaggcaggg cttgcagtga gccaagatca tgccgctgca ctccagcctg     3480

ggagacaaag tgagactccg tcaaaaaaaa aaaaaagtct atgtggtcag tcactactct     3540

tgctgcagtt atgaaaagaa tgaggccaag tctgatgaaa ataaacttat tttgaaaaca     3600


<210>  7
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  7
aagacttagg aagactggtg gatgcgtttg ggttgtagct aggctttttc ttttctttct       60

cttttaaaac acatctagac aaggaaaaaa caagcctcgg atctgatttt tcactcctcg      120

ttcttgtgct tggttcttac tgtgtttgtg tattttaaag gcgagaagac gaggggaaca      180

aaaccagctg gatccatcca tcaccgtggg tggttttaat ttttcgtttt ttctcgttat      240

ttttttttaa acaaccactc ttcacaatga acaaactgta tatcggaaac ctcagcgaga      300

acgccgcccc ctcggaccta gaaagtatct tcaaggacgc caagatcccg gtgtcgggac      360

ccttcctggt gaagactggc tacgcgttcg tggactgccc ggacgagagc tgggccctca      420

aggccatcga ggcgctttca ggtaaaatag aactgcacgg gaaacccata gaagttgagc      480

actcggtccc aaaaaggcaa aggattcgga aacttcagat acgaaatatc ccgcctcatt      540

tacagtggga ggtgctggat agtttactag tccagtatgg agtggtggag agctgtgagc      600

aagtgaacac tgactcggaa actgcagttg taaatgtaac ctattccagt aaggaccaag      660

ctagacaagc actagacaaa ctgaatggat ttcagttaga gaatttcacc ttgaaagtag      720

cctatatccc tgatgaaatg gccgcccagc aaaacccctt gcagcagccc cgaggtcgcc      780

gggggcttgg gcagaggggc tcctcaaggc aggggtctcc aggatccgta tccaagcaga      840

aaccatgtga tttgcctctg cgcctgctgg ttcccaccca atttgttgga gccatcatag      900

gaaaagaagg tgccaccatt cggaacatca ccaaacagac ccagtctaaa atcgatgtcc      960

accgtaaaga aaatgcgggg gctgctgaga agtcgattac tatcctctct actcctgaag     1020

gcacctctgc ggcttgtaag tctattctgg agattatgca taaggaagct caagatataa     1080

aattcacaga agagatcccc ttgaagattt tagctcataa taactttgtt ggacgtctta     1140

ttggtaaaga aggaagaaat cttaaaaaaa ttgagcaaga cacagacact aaaatcacga     1200

tatctccatt gcaggaattg acgctgtata atccagaacg cactattaca gttaaaggca     1260

atgttgagac atgtgccaaa gctgaggagg agatcatgaa gaaaatcagg gagtcttatg     1320

aaaatgatat tgcttctatg aatcttcaag cacatttaat tcctggatta aatctgaacg     1380

ccttgggtct gttcccaccc acttcaggga tgccacctcc cacctcaggg cccccttcag     1440

ccatgactcc tccctacccg cagtttgagc aatcagaaac ggagactgtt catctgttta     1500

tcccagctct atcagtcggt gccatcatcg gcaagcaggg ccagcacatc aagcagcttt     1560

ctcgctttgc tggagcttca attaagattg ctccagcgga agcaccagat gctaaagtga     1620

ggatggtgat tatcactgga ccaccagagg ctcagttcaa ggctcaggga agaatttatg     1680

gaaaaattaa agaagaaaac tttgttagtc ctaaagaaga ggtgaaactt gaagctcata     1740

tcagagtgcc atcctttgct gctggcagag ttattggaaa aggaggcaaa acggtgaatg     1800

aacttcagaa tttgtcaagt gcagaagttg ttgtccctcg tgaccagaca cctgatgaga     1860

atgaccaagt ggttgtcaaa ataactggtc acttctatgc ttgccaggtt gcccagagaa     1920

aaattcagga aattctgact caggtaaagc agcaccaaca acagaaggct ctgcaaagtg     1980

gaccacctca gtcaagacgg aagtaaaggc tcaggaaaca gcccaccaca gaggcagatg     2040

ccaaaccaaa gacagattgc ttaaccaaca gatgggcgct gaccccctat ccagaatcac     2100

atgcacaagt ttttacctag ccagttgttt ctgaggacca ggcaactttt gaactcctgt     2160

ctctgtgaga atgtatactt tatgctctct gaaatgtatg acacccagct ttaaaacaaa     2220

caaacaaaca aacaaaaaaa gggtggggga gggagggaaa gagaagagct ctgcacttcc     2280

ctttgttgta gtctcacagt ataacagata ttctaattct tcttaatatt cccccataat     2340

gccagaaatt ggcttaatga tgctttcact aaattcatca aatagattgc tcctaaatcc     2400

aattgttaaa attggatcag aataattatc acaggaactt aaatgttaag ccattagcat     2460

agaaaaactg ttctcagttt tatttttacc taacactaac atgagtaacc taagggaagt     2520

gctgaatggt gttggcaggg gtattaaacg tgcattttta ctcaactacc tcaggtattc     2580

agtaatacaa tgaaaagcaa aattgttcct tttttttgaa aattttatat actttataat     2640

gatagaagtc caaccgtttt ttaaaaaata aatttaaaat ttaacagcaa tcagctaaca     2700

ggcaaattaa gatttttact tctggctggt gacagtaaag ctggaaaatt aatttcaggg     2760

ttttttgagg cttttgacac agttattagt taaatcaaat gttcaaaaat acggagcagt     2820

gcctagtatc tggagagcag cactaccatt tattctttca tttatagttg ggaaagtttt     2880

tgacggtact aacaaagtgg tcgcaggaga ttttggaacg gctggtttaa atggcttcag     2940

gagacttcag ttttttgttt agctacatga ttgaatgcat aataaatgct ttgtgcttct     3000

gactatcaat acctaaagaa agtgcatcag tgaagagatg caagactttc aactgactgg     3060

caaaaagcaa gctttagctt gtcttatagg atgcttagtt tgccactaca cttcagacca     3120

atgggacagt catagatggt gtgacagtgt ttaaacgcaa caaaaggcta catttccatg     3180

gggccagcac tgtcatgagc ctcactaagc tattttgaag atttttaagc actgataaat     3240

taaaaaaaaa aaattagact ccaccttaag tagtaaagta taacaggatt tctgtatact     3300

gtgcaatcag ttctttgaaa aaaaagtcaa aagatagaga atacaagaaa agtttttggg     3360

atataatttg aatgactgtg aaaacatatg acctttgata acgaactcat ttgctcactc     3420

cttgacagca aagcccagta cgtacaattg tgttgggtgt gggtggtctc caaggccacg     3480

ctgctctctg aattgatttt ttgagttttg tttgtaagat gatcacagtc atgttacact     3540

gatctaaagg acatatatat aaccctttaa aaaaaaaatc actgcctcat tcttatttca     3600

agatgaattt ctatacagac tagatgtttt tctgaagatc aattagacat tttgaaaatg     3660

atttaaagtg ttttccttaa tgttctctga aaacaagttt cttttgtagt tttaaccaaa     3720

aaagtgccct ttttgtcact ggattctcct agcattcatg attttttttt catacaatga     3780

attaaaattg ctaaaatcat ggactggctt tctggttgga tttcaggtaa gatgtgttta     3840

aggccagagc ttttctcagt atttgatttt tttccccaat atttgatttt ttaaaaatat     3900

acacataggt gctgcattta tatctgctgg tttaaattct gtcatatttc acttctagcc     3960

ttttagtatg gcaaatcata ttttactttt acttaagcat ttgtaatttg gagtatctgg     4020

tactagctaa gaaataattc tataattgag ttttgtactc accatatatg gatcattcct     4080

catgtataat gtgccccaaa tgcagcttca ttttccagat accttgacgc agaataaatt     4140

ttttcatcat ttaggtgcaa aaaaaaaa                                        4168


<210>  8
<211>  2049
<212>  DNA
<213>  Homo sapiens

<400>  8
atccatttgt tctcaagagg tagcaagaaa cagtatccac agtggactcc ggggctccta       60

cagacttggc acagcttcct acagtcttga aacagccctg ttgttctgtc atggccagtg      120

ggcagtttgt gaacaaactg caagaggaag tgatctgccc catctgcctg gacattctgc      180

agaaacctgt caccatcgac tgtgggcaca atttctgcct caaatgcatc actcagattg      240

gggaaacatc atgtggattt ttcaaatgtc ccctctgcaa aacttccgta aggaagaacg      300

caatcaggtt caactcgctg ttgcggaatc tggtggagaa aatccaagct ctacaagcct      360

ctgaggtgca gtccaaaagg aaagaggcta catgcccgag gcaccaggag atgttccact      420

atttctgcga ggatgatggg aagttcctct gttttgtgtg tcgtgaatcc aaggaccaca      480

aatcccataa tgtcagcttg atcgaagaag ctgcccagaa ttatcagggg cagattcaag      540

agcagatcca agtcttgcag caaaaggaga aggagacagt acaagtgaag gcacaaggtg      600

tacacagggt cgatgtcttc acggaccagg tagaacatga gaagcaaagg atcctcacag      660

aatttgaact cctgcatcaa gtcctagagg aggagaagaa tttcctgcta tcacggattt      720

actggctggg tcatgaggga acggaagcgg ggaaacacta tgttgcctcc actgagccac      780

agttgaacga tctcaagaag ctcgttgatt ccctgaagac caagcagaac atgccaccca      840

ggcagctgct ggaggatatc aaagtcgtct tgtgcagaag tgaagagttt cagtttctca      900

acccaacccc tgttcctctg gaactggaga aaaaactcag tgaagcaaaa tcaagacatg      960

actccatcac agggagccta aaaaaattca aagaccaact ccaggctgat aggaaaaaag     1020

atgaaaacag attcttcaaa agcatgaata aaaatgacat gaagagctgg ggcttgttac     1080

agaaaaataa tcataaaatg aacaaaacct cagagcccgg gtcatcttct gcaggcggca     1140

gaactacatc ggggccacca aatcaccact cttcagcccc atcccactcc ctgtttcggg     1200

cctcgtctgc tgggaaagtc acttttccag tatgtctcct ggcctcttat gatgagattt     1260

ctggtcaagg agcgagctct caggatacga agacatttga cgttgcgctg tccgaggagc     1320

tccatgcggc actgagtgag tggctgacag cgatccgggc ttggttttgt gaggttcctt     1380

caagctaagc cagctcagag aacacgggga gcggtggtgc tacacggact tcggagcata     1440

gagtggcgct gagtgagtgg ctgagaccga ccacggttct tgacttagtg gaattgggtc     1500

gaaggagtgg agaatgggag ggctcgggct actgagagtg gagatggggg cgggggtggt     1560

ggtgaagaga gttggagaag gaatggacga attcttgagc aaaaggaggg gaagagacaa     1620

tctccagcca cccgccccac gcttgacttc ttatcacttt ggctgtggtg ccgcctagtg     1680

gaaaaaggaa gtccctgcag cagtccccgc actctttaag cagctgttta ccgaaggcac     1740

cagttcagcc aggagtgaaa tccggagagg agcaacgcca gcctgggtca cagtccatca     1800

aaccccatga gcccgaccac tctcgctctt ccttacattc ccacgtcccc cttctctccc     1860

aacccctcat atcagcaagg gaaattaatt aatgagattt gataaatcag tagatagaat     1920

gaggtcccca ttctgaaata tttagcagac tggaaccacc acgcaagcct ctgtaggggg     1980

tggatggaga cacttctaac tttaataaac tgcgactgaa cgtggaaaaa aaaaaaaaaa     2040

aaaaaaaaa                                                             2049


<210>  9
<211>  2240
<212>  DNA
<213>  Homo sapiens

<400>  9
gccccactcc tcgctcgcac ctcgctcgcg ccagcccttc ccgctcttct gttctcgctc       60

tatttgcccc gctgactgct ggcctcgcca gctttgccag tcttacgtct ctgccgcccc      120

cactcccgcc cgcgccccat cttcttgcgc gactcgcgcc cgctggtccc cccctcctcc      180

tcccgcgtcc tgcctgcccc ctcctcctgc tctcgcaggc tccttggcac ccaggccggg      240

aggcgacgcg cccagccgtc taaacgggaa cagccctggc tgagggagct gcagcgcagc      300

agagtatctg acggcgccag gttgcgtagg tgcggcacga ggagttttcc cggcagcgag      360

gaggtcctga gcagcatggc ccggaggagc gccttccctg ccgccgcgct ctggctctgg      420

agcatcctcc tgtgcctgct ggcactgcgg gcggaggccg ggccgccgca ggaggagagc      480

ctgtacctat ggatcgatgc tcaccaggca agagtactca taggatttga agaagatatc      540

ctgattgttt cagaggggaa aatggcacct tttacacatg atttcagaaa agcacaacag      600

agaatgccag ctattcctgt caatatccat tccatgaatt ttacctggca agctgcaggg      660

caggcagaat acttctatga attcctgtcc ttgcgctccc tggataaagg catcatggca      720

gatccaaccg tcaatgtccc tctgctggga acagtgcctc acaaggcatc agttgttcaa      780

gttggtttcc catgtcttgg aaaacaggat ggggtggcag catttgaagt ggatgtgatt      840

gttatgaatt ctgaaggcaa caccattctc caaacacctc aaaatgctat cttctttaaa      900

acatgtcaac aagctgagtg cccaggcggg tgccgaaatg gaggcttttg taatgaaaga      960

cgcatctgcg agtgtcctga tgggttccac ggacctcact gtgagaaagc cctttgtacc     1020

ccacgatgta tgaatggtgg actttgtgtg actcctggtt tctgcatctg cccacctgga     1080

ttctatggag tgaactgtga caaagcaaac tgctcaacca cctgctttaa tggagggacc     1140

tgtttctacc ctggaaaatg tatttgccct ccaggactag agggagagca gtgtgaaatc     1200

agcaaatgcc cacaaccctg tcgaaatgga ggtaaatgca ttggtaaaag caaatgtaag     1260

tgttccaaag gttaccaggg agacctctgt tcaaagcctg tctgcgagcc tggctgtggt     1320

gcacatggaa cctgccatga acccaacaaa tgccaatgtc aagaaggttg gcatggaaga     1380

cactgcaata aaaggtacga agccagcctc atacatgccc tgaggccagc aggcgcccag     1440

ctcaggcagc acacgccttc acttaaaaag gccgaggagc ggcgggatcc acctgaatcc     1500

aattacatct ggtgaactcc gacatctgaa acgttttaag ttacaccaag ttcatagcct     1560

ttgttaacct ttcatgtgtt gaatgttcaa ataatgttca ttacacttaa gaatactggc     1620

ctgaatttta ttagcttcat tataaatcac tgagctgata tttactcttc cttttaagtt     1680

ttctaagtac gtctgtagca tgatggtata gattttcttg tttcagtgct ttgggacaga     1740

ttttatatta tgtcaattga tcaggttaaa attttcagtg tgtagttggc agatattttc     1800

aaaattacaa tgcatttatg gtgtctgggg gcaggggaac atcagaaagg ttaaattggg     1860

caaaaatgcg taagtcacaa gaatttggat ggtgcagtta atgttgaagt tacagcattt     1920

cagattttat tgtcagatat ttagatgttt gttacatttt taaaaattgc tcttaatttt     1980

taaactctca atacaatata ttttgacctt accattattc cagagattca gtattaaaaa     2040

aaaaaaaatt acactgtggt agtggcattt aaacaatata atatattcta aacacaatga     2100

aatagggaat ataatgtatg aactttttgc attggcttga agcaatataa tatattgtaa     2160

acaaaacaca gctcttacct aataaacatt ttatactgtt tgtatgtata aaataaaggt     2220

gctgctttag ttttctgagc                                                 2240


<210>  10
<211>  8351
<212>  DNA
<213>  Homo sapiens

<400>  10
ctgccgtcgt ggaagcagga tttccgcggt tgtgtaacgg cctgtcgcag gcgtgcaggg       60

acctggactc cgcctcgtcc ccggggctcg ggcagccgag ccatggcggg gaactgtggg      120

gcccgcggcg cgctgtcggc gcacacgctg ctgttcgacc tgccgcccgc gctgctcgga      180

gagctctgcg ctgttctgga cagctgcgac ggcgcgctgg gctggcgcgg cctggcagag      240

agactttcaa gcagctggct ggatgttcgt catattgaaa agtatgtaga ccaaggtaaa      300

agtggaacaa gagaattact ttggtcctgg gcacagaaaa acaagaccat cggtgacctt      360

ttacaggtcc tccaggagat gggacatcgt cgagctattc atttaattac aaactatgga      420

gcagtgttga gtccttcaga gaagagttat caggaaggtg gatttccaaa tatattattc      480

aaggaaacag ccaatgtcac cgtggataat gttcttattc ctgaacataa tgaaaaagga      540

atactgctta aatcttccat cagctttcaa aatatcatag aaggaactag aaatttccac      600

aaagacttcc taattggaga aggagagatt tttgaggtat acagagtgga gattcaaaac      660

ctaacatatg ctgtcaaatt atttaaacag gagaaaaaaa tgcagtgtaa gaagcattgg      720

aagaggtttt tatctgagct tgaagtttta ctactgtttc atcacccaaa catactagag      780

ttggctgcat attttacaga gactgagaag ttctgtctga tttatccata catgagaaat      840

ggaacacttt ttgacagatt gcagtgtgta ggtgacacgg ccccactccc ttggcacatt      900

cgaatcggta tattaatagg aatatccaaa gccattcact acctgcacaa cgttcaacca      960

tgctcggtca tctgtggcag tatatcaagt gcaaacatcc ttttggatga tcagtttcaa     1020

cccaaactaa ctgattttgc catggcacac ttccggtccc acctagaaca tcagagttgt     1080

accataaata tgaccagcag cagcagtaaa catctgtggt acatgccaga agagtacatc     1140

agacagggga aactttccat taaaacagat gtctacagct ttggaattgt aataatggaa     1200

gttctaacag gatgtagagt agtgttagat gatccaaaac atatccagct gcgggatctc     1260

cttagagaat tgatggagaa gagaggcctg gattcatgtc tctcatttct agataagaaa     1320

gtgcctccct gccctcggaa tttctctgcc aagctcttct gtttggcagg ccggtgtgct     1380

gcaacgcggg caaagttaag accatcaatg gatgaagttt taaatactct tgaaagtact     1440

caagccagct tgtattttgc tgaagatcct cccacatcac taaagtcctt caggtgtcct     1500

tctcctctat tcctggagaa tgtaccaagt attccagtgg aagatgatga aagccagaat     1560

aacaatttac taccttctga tgaaggcctg aggatagaca gaatgactca gaaaactcct     1620

tttgaatgca gccagtctga ggttatgttt ctgagcttgg acaaaaagcc agagagcaag     1680

agaaatgagg aagcttgcaa catgcccagt tcttcttgtg aagaaagttg gttcccaaag     1740

tatatagttc catcccagga cttaaggccc tataaggtaa atatagatcc ttcttcagaa     1800

gctccagggc attcttgcag gagcaggcca gtggagagca gctgttcctc caaattttcc     1860

tgggatgaat atgaacagta caaaaaagaa taaattctac cagaagataa agaaaaaagc     1920

aagtattgca taggcacctg agcataggta tgaccttggg aagacattgg ctccataagc     1980

aatgccaaga gaatgatcaa tagtgagttt gggtgatgca gataaacaat ctggataatt     2040

ccatttcttt tttcccaaac cctcaaacag agtgccttaa aaaattgttt tatcaggata     2100

attgtctcat gaccaaatcc acgctcaatt agagccattc aaaattcctt aagatcatgg     2160

gttctgactt cagccaaaca aaacaatcaa aacctaccaa aaagggactg gattgtaatg     2220

tcctctccat catcctcagt gtgagtcctc agagcctcca tctgccaaga acattcagtt     2280

ggattccatc gtttggttta gcttgcttgc acgggttgta ggaaatgtct aatttgtaaa     2340

tgttaataga tacctttgga aagaatcacc ttgttattct gattgacccc tcttgttttt     2400

tggttaatcc ctgactagcc tgcttgtctg aaaatgagcc aggttcaccc ttagctacgg     2460

catgctctgg gttgaaaggg gatttcttcc caagatctat cctaaactct taggacagtt     2520

tatcctgtat tgactattat tacagctttt taaaaacaga cttagtgacc tattatatct     2580

taaggagact atgtgaaatg tccatcaagt aatttttatt cctgagaaaa tggctggtca     2640

agggcctagg tcagcttttt gtttaatcta cacctttcaa ctctgggcct tcattcctgc     2700

tgtttcttgg atctccctct tttgaaatcc taccaatcat cagagctcta caaaacagcc     2760

acctcctgga agcttcccta atctctacaa ccagaagtac tccctttatc agtatttcca     2820

cagcaatttc tttgtatttc tattttatat ttatcacttt ctgaattata tcaaagctgc     2880

ttgtcttatc tctttttttt tttgagacgg agtctcgctc tgtcatccag gctggagtgc     2940

agtggcacaa tctcggctca ccgcaaggtc tgcctcccgg gttcacgcca ttctcctgcc     3000

tcagcctccc gagtaaaggt gggactacag gcgcccgcca ctacgcccgg ctaatttttt     3060

gtatttttag tagagacggg gtttcaccat gttaggcagg atggtctcga tctcctgacc     3120

tcatgatccg cctgcctggc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc     3180

cagccttcat ctcttttact aggttgtaaa ctccctatat tagttttcta ttgtttttgt     3240

aacacattat cacaaattta gtgacttaaa gtaacataaa ttaattattt tgcagttctg     3300

gaggtcagaa ttccttagca ttctttctgg aggctgttgg ggagaactca ctgccttgcc     3360

ttttccagct tctagaggcc acctgccttc tttggctcat ggcctcttcc tccgtcttca     3420

aagccagcaa cgtgacattt cagatctccc tctctctgtc tgtctcaccg catctcttca     3480

ctaccctctt cctctcattc tggcccttct gcatgtcttt tataaagacc tttgtgattt     3540

cactgggccc actcatataa gccaggaaaa tctctgtgtc tcagatcctt aatttaatta     3600

cacctgcaaa gtccgttttc tcgtgtaaag taacatattc acaggtttct ggaattggga     3660

cgtggacatc ttcgggggac cattactctg tctgtcatac tccctgagtg tgtaagggcc     3720

atctcttcag agcctaatgt gtcatcctac acagagcagg tgtttcctta taaattaagt     3780

tgaattaaat tacccctatg aagccacata atcaataatt cagctataat aaacattgcc     3840

gaataaatta acaaagggag gataatgact ccttatgatg atggatagaa acactgaaga     3900

aaaccatttt cagaggattt actgaatttt cctctccaag gagcttgtaa tagaagggta     3960

aacctctagt ttcttgtcca gcagaggaat aggctcatgt cttttgtttt attttatttt     4020

tttggtgagt cagtatggtt gggttaatca tattcacatt agattccatg ttgaagaaca     4080

actaatcaaa gaagaaaatc atcaggaatc agggtgagat taacagacca aggtcagaaa     4140

catggagtta caattttcca aaaaagcacg aagtgagatt aaaaccacag taagtcttag     4200

tctgactgac aggctttata caggccctcg gtaagcagtt gggagaaccc atgcccacca     4260

ctgctctgta cggtatctgg ctgctcagag ctctctgatt cacaaaagag atcatcaaga     4320

attgactctg tgttaaactg tttttcactt agaatatgga cccccaccaa tacattcaat     4380

gaagggtcat taaggaagct ctgattaaca ccaggcccat gcagttactc cgcacatata     4440

atctgtgggt attatgttga tttgaacttg cttagctgac ttaaagcagg gtttctcaaa     4500

ctgtagtatg catcagaatg acttggaaag ctggttaaaa acgcagattg ctgggtccac     4560

ccagcttctg atgcaatagg tctggggtta gaaattttgc tttctaatga gttcccaggt     4620

gatgctgatg ccaatgatgt gaagcccgct cttcacatcc gtgaaaatcg ctgccttaag     4680

gtgctcttaa attgttatag attggtagat cctacctttc catcactggt atgttttttg     4740

agaaaaggat cctttctttt cattctgtta tattcatcct attacatagg atgttggtta     4800

gcacagagtg ggagctctag aaagattgtt gaccaatcat cttattgact agaccatctt     4860

tctagagtat aactattttg gacacctcaa agatgaagtc agataagctg gcagtgacct     4920

gattaacgtt gtggtaagca gatgccactg tggctgggaa gtaccaaatc ttctgttgag     4980

tgattcagtc ttcctgacta gatttgcctt ctagtgggtg tattaataag cgttagttga     5040

tatgaattaa atgttgcaac tttctatggg taataagagg atacctttat agtttcatga     5100

tgtggagacc aagatacata agaaagcaag aatgagtctc cgggtgttcc ctctgatcag     5160

caaacatgaa ttcataattt catttactct catttttgta atgcactctg agcaatcctc     5220

caggcagatc ctatttacta agcttcaggc ttttgtccca ttttataatg cccaaacaca     5280

tggagaaaac attttgttgt ttttaaaaac aggtatggga tttctgatat aatcaatttt     5340

attgacttct tgggagttgt aatgatctgt gactcactgc ataatattgt agttttatag     5400

ggtggcacat caccctgtgt aaaacaactt taatgacctg aggactgatg agtacaggaa     5460

gtgaggttta tcatgagtag catttattaa gcatctgcta gaatcaaagc actgcattag     5520

ctactaaggt acaaagtaag acacagttta ataaggaaga cagggcatct acccaagtca     5580

acagttcagt gacatctgtt atttgaacca cacaccaatg caaccgaagt aaatgctgaa     5640

agggtgagaa gaaggaatag attactatgc atttttgaga ggatgaagaa ggcttcttgg     5700

agaaggtttc tgaaaagaga tacggaatta agagaaatag aaaagagcac tgacgaagca     5760

ctcaggatgg ctattcaagg aattggggat ccacagcagc tgtgcacaac catccctaat     5820

gccagaaaaa tggggtaagg gtgaagggaa ctgggtctag agctttgcat gtttttttct     5880

ggttaaccct tagagtcacc ctgaaggtgt ggatcccatc ttataataag gtgaggacac     5940

tgagtcagga aactaacttg ctaaaatcaa gtcctcccag tcctcccatc aggtccttcc     6000

agatctggag gagccaggat ttgaactcac atttgtctga cttcaaaatc catgcttttt     6060

cttgtgttcc aaattgcaca atggagtcac tgccagttca agctcctatg aaaagggatg     6120

gatgtgaaaa gtcatttgtt gattccacag atttttagta ggtaccatgt ctcctgcctt     6180

tatcactatc ctactcctct gctacaactt ctctgctaca ggcacccact gcagttactt     6240

gatatgagtt aaatgaatcc atccatccaa acttccattc attgaataaa tacttagcaa     6300

tggcttcctt tgtatcaggc actattctag gagctggggc tacagtgcag atggaaacca     6360

gcaaagctca ctgccctcat ggagcttata tgtaagtgaa taaatctcag ggtggttctc     6420

ctgtcatagg tcctggctcc tctgccagct cttccaaatg ggttcagaga ggttttctcc     6480

ttgtcctgtt gtgtaactga taatcccatg gtggacctca ctttgctatt catatgcact     6540

aagtagttta tggtgtgctt tgtggctggc aattgtgaca gattctattc ttctattggt     6600

atgtggtttc tttggggcat ttgtttggat actgatggca tcttccgggg gtctgaggca     6660

cctacacaaa cctcaggtca ctatcacgtg atactggagt tgcctgttaa attatatttc     6720

ttcttccaca aaactgcagg ttccctgagg gaaaggtcta tgtcctgctc atttttggat     6780

ccctaatggc tggcacagta cctggtgcat aatatggttc aacaaatatt tgtaaaatga     6840

atgaatcaaa tagtccttca aagcatcttc agaatcaaga ttgtcatcta gattgcaccc     6900

gaagtttatc tttctagtat tcagaatata atcaatcatt gcttaaatta ttccatttca     6960

tcattcttga ataaaagcta ctaattttaa atactaatat ctgagatatc ttcgaaaaga     7020

agattagtcg ttgtatgtgt tgcttataaa ttttctctat ggtggaaaat attcccaaac     7080

catgtctaag caatgaaaaa ccagtgttct ggcaggaaat aaactgatgt ttgttgtgtt     7140

ttgtatctgt cttcccgttc caaatcattt atatatactt gatggtctgt gggcttgact     7200

tgcaagtatt ttcctgggag acatttttat tcaaaagacc tgtattgcct gccaaacctt     7260

catttaagag actcattatg gatgtcatct gcatcattgc aaacttttct ggtcgtctct     7320

ataaatagca agataatatt tacagagttt tacattggct cttgaatttt aaaatattct     7380

tatagacaaa cattaattgg aatggggggt aaggaggtag gaatggctta cttgcggaaa     7440

tgcaggctca ttgttgtgtc tagtaggtgc taggtgcatt cacacatctc ttaagcttta     7500

aacaacctat tgagccggtt tccatttcct tgatctatta gatttaaaaa aatgaagcat     7560

aaaggagttg gctcttgccc taagtcatac tactgatgga atgagaatac aaaccaaaaa     7620

cactttattc aagtccagga aatatctgcc ttgaaaaaga ataacttaaa aattaaaagt     7680

gtcctctatt tgaacatgaa aacagctaat aaagatgtgt tattttattt tattattatt     7740

aattttgtcc tcccatattg gcaaagataa agcaattgac aaaaatggaa ttcttgttca     7800

atactggcag gagtgaaaat tggtagaacc tttctagaag gcaatttggc aacatgtatg     7860

aaaacctaaa tgttgataca cctttaccca gcagtttgtt taggaattta tcctaatgaa     7920

taaaagttgt ccaagtcttc aaacatgagc ccaaaggtat atttcatgat gtttatgata     7980

ttaaaacatt ggaaacaact gaaacatcct tcagtaaaag atggattaaa taaattccat     8040

gcagttgtca tttaaaaata tttagatata tgtttattgc tatggatata tgttcccaaa     8100

atattattga atcaaaaagt agactacagg atatatgttg aatatgagct catttataac     8160

attgaatatt ttaagataat gtatgtttca tagagagatc ttcaccaaat gttaaggatt     8220

tttttttctg ggctgtggta tttgggtgat ctttacattc ttcagactca tgtgtgtttg     8280

aaacttttta taatgaacat atatcatttt tattagaaaa gaataaagtt tttgaaaaaa     8340

aaaaaaaaaa a                                                          8351


<210>  11
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  11
acactttgta tggcaagtgg aaccactggc ttggtggatt ttgctagatt tttctgattt       60

ttaaactcct gaaaaatatc ccagataact gtcatgaagc tggtaactat cttcctgctg      120

gtgaccatca gcctttgtag ttactctgct actgccttcc tcatcaacaa agtgcccctt      180

cctgttgaca agttggcacc tttacctctg gacaacattc ttccctttat ggatccatta      240

aagcttcttc tgaaaactct gggcatttct gttgagcacc ttgtggaggg gctaaggaag      300

tgtgtaaatg agctgggacc agaggcttct gaagctgtga agaaactgct ggaggcgcta      360

tcacacttgg tgtgacatca agataaagag cggaggtgga tggggatgga agatgatgct      420

cctatcctcc ctgcctgaaa cctgttctac caattataga tcaaatgccc taaaatgtag      480

tgacccgtga aaaggacaaa taaagcaatg aatacattaa                            520


<210>  12
<211>  2272
<212>  DNA
<213>  Homo sapiens

<400>  12
attgctgtgt caagttccag agaaaagctt ctgttcgtcc aagttactaa ccaggctaaa       60

ccacatagac gtgaaggaag gggctagaag gaagggagtg ccccactgtt gatggggtaa      120

gaggatcctg tactgagaag ttgaccagag agggtctcac catgcgcaca gttccttctg      180

tacctgtgtg gaggaaaagt actgagtgaa gggcagaaaa agagaaaaca gaaatgctct      240

gcccttggag aactgctaac ctagggctac tgttgatttt gactatcttc ttagtggccg      300

aagcggaggg tgctgctcaa ccaaacaact cattaatgct gcaaactagc aaggagaatc      360

atgctttagc ttcaagcagt ttatgtatgg atgaaaaaca gattacacag aactactcga      420

aagtactcgc agaagttaac acttcatggc ctgtaaagat ggctacaaat gctgtgcttt      480

gttgccctcc tatcgcatta agaaatttga tcataataac atgggaaata atcctgagag      540

gccagccttc ctgcacaaaa gcctacaaga aagaaacaaa tgagaccaag gaaaccaact      600

gtactgatga gagaataacc tgggtctcca gacctgatca gaattcggac cttcagattc      660

gtaccgtggc catcactcat gacgggtatt acagatgcat aatggtaaca cctgatggga      720

atttccatcg tggatatcac ctccaagtgt tagttacacc tgaagtgacc ctgtttcaaa      780

acaggaatag aactgcagta tgcaaggcag ttgcagggaa gccagctgcg catatctcct      840

ggatcccaga gggcgattgt gccactaagc aagaatactg gagcaatggc acagtgactg      900

ttaagagtac atgccactgg gaggtccaca atgtgtctac cgtgacctgc cacgtctccc      960

atttgactgg caacaagagt ctgtacatag agctacttcc tgttccaggt gccaaaaaat     1020

cagcaaaatt atatattcca tatatcatcc ttactattat tattttgacc atcgtgggat     1080

tcatttggtt gttgaaagtc aatggctgca gaaaatataa attgaataaa acagaatcta     1140

ctccagttgt tgaggaggat gaaatgcagc cctatgccag ctacacagag aagaacaatc     1200

ctctctatga tactacaaac aaggtgaagg catctgaggc attacaaagt gaagttgaca     1260

cagacctcca tactttataa gttgttggac tctagtacca agaaacaaca acaaacgaga     1320

tacattataa ttactgtctg attttcttac agttctagaa tgaagactta tattgaaatt     1380

aggttttcca aggttcttag aagacatttt aatggattct cattcatacc cttgtataat     1440

tggaattttt gattcttagc tgctaccagc tagttctctg aagaactgat gttattacaa     1500

agaaaataca tgcccatgac caaatattca aattgtgcag gacagtaaat aatgaaaacc     1560

aaatttcctc aagaaataac tgaagaagga gcaagtgtga acagtttctt gtgtatcctt     1620

tcagaatatt ttaatgtaca tatgacatgt gtatatgcct atggtatatg tgtcaattta     1680

tgtgtcccct tacatataca tgcacatatc tttgtcaagg caccagtggg aacaatacac     1740

tgcattactg ttctatacat atgaaaacct aataatataa gtcttagaga tcattttata     1800

tcatgacaag tagagctacc tcattctttt taatggttat ataaaattcc attgtatagt     1860

tatatcatta tttaattaaa aacaacccta atgatggata tttagattct tttaagtttt     1920

gtttatttct tttaagtttt gtttgtggta taaacaatac cacatagaat gtttcttgtg     1980

catatatctc tttgtttttg agtatatctg taggataact ttcttgagtg gaattgtcag     2040

gtcaaagggt ttgtgcattt tactattgat atatatgtta aattgtgtca aatatatatg     2100

tcaaattccc tccaacattg tttaaatgtg cctttcccta aatttctatt ttaataactg     2160

tactattcct gcttctacag ttgccacttt ctctttttaa tcaaccagat taaatatgat     2220

gtgagattat aataagaatt atactattta ataaaaatgg atttatattt tt             2272


<210>  13
<211>  9464
<212>  DNA
<213>  Homo sapiens

<400>  13
gctatgaatt tctcctcaca aggatgggcc tgtttactca ccctgggcat cgttggtaga       60

gcgctagtgt aaacagcctg aggaacccgg tgggccgggg aagtgggcgc gctctgttct      120

ccgcggccag ctgggacgcc gggccaggtg gggccgcctg cgtttagcaa ctgctttctc      180

accccctgga tttgcgatgt ttgccacagc agcgagaagc gccattgtaa tggggatggg      240

aggggtggag cctccaagtc ctgtctcaat ttagatctct cactctgctg ttaggcgcgc      300

ccatttcaga ttactaaact cgaattaaga gggaaaaaaa atcagggagg aggtggcaag      360

ccacacccca cggtgcccgc gaacttcccc ggcagcggac tgtagcccag gcagacgccg      420

tcgagatgca gggcccaccg ctcctgaccg ccgcccacct cctctgcgtg tgcaccgccg      480

cgctggccgt ggctcccggg cctcggtttc tggtgacagc cccagggatc atcaggcccg      540

gaggaaatgt gactattggg gtggagcttc tggaacactg cccttcacag gtgactgtga      600

aggcggagct gctcaagaca gcatcaaacc tcactgtctc tgtcctggaa gcagaaggag      660

tctttgaaaa aggctctttt aagacactta ctcttccatc actacctctg aacagtgcag      720

atgagattta tgagctacgt gtaaccggac gtacccagga tgagatttta ttctctaata      780

gtacccgctt atcatttgag accaagagaa tatctgtctt cattcaaaca gacaaggcct      840

tatacaagcc aaagcaagaa gtgaagtttc gcattgttac actcttctca gattttaagc      900

cttacaaaac ctctttaaac attctcatta aggaccccaa atcaaatttg atccaacagt      960

ggttgtcaca acaaagtgat cttggagtca tttccaaaac ttttcagcta tcttcccatc     1020

caatacttgg tgactggtct attcaagttc aagtgaatga ccagacatac tatcaatcat     1080

ttcaggtttc agaatatgta ttaccaaaat ttgaagtgac tttgcagaca ccattatatt     1140

gttctatgaa ttctaagcat ttaaatggta ccatcacggc aaagtataca tatgggaagc     1200

cagtgaaagg agacgtaacg cttacatttt tacctttatc cttttgggga aagaagaaaa     1260

atattacaaa aacatttaag ataaatggat ctgcaaactt ctcttttaat gatgaagaga     1320

tgaaaaatgt aatggattct tcaaatggac tttctgaata cctggatcta tcttcccctg     1380

gaccagtaga aattttaacc acagtgacag aatcagttac aggtatttca agaaatgtaa     1440

gcactaatgt gttcttcaag caacatgatt acatcattga gttttttgat tatactactg     1500

tcttgaagcc atctctcaac ttcacagcca ctgtgaaggt aactcgtgct gatggcaacc     1560

aactgactct tgaagaaaga agaaataatg tagtcataac agtgacacag agaaactata     1620

ctgagtactg gagcggatct aacagtggaa atcagaaaat ggaagctgtt cagaaaataa     1680

attatactgt cccccaaagt ggaactttta agattgaatt cccaatcctg gaggattcca     1740

gtgagctaca gttgaaggcc tatttccttg gtagtaaaag tagcatggca gttcatagtc     1800

tgtttaagtc tcctagtaag acatacatcc aactaaaaac aagagatgaa aatataaagg     1860

tgggatcgcc ttttgagttg gtggttagtg gcaacaaacg attgaaggag ttaagctata     1920

tggtagtatc caggggacag ttggtggctg taggaaaaca aaattcaaca atgttctctt     1980

taacaccaga aaattcttgg actccaaaag cctgtgtaat tgtgtattat attgaagatg     2040

atggggaaat tataagtgat gttctaaaaa ttcctgttca gcttgttttt aaaaataaga     2100

taaagctata ttggagtaaa gtgaaagctg aaccatctga gaaagtctct cttaggatct     2160

ctgtgacaca gcctgactcc atagttggga ttgtagctgt tgacaaaagt gtgaatctga     2220

tgaatgcctc taatgatatt acaatggaaa atgtggtcca tgagttggaa ctttataaca     2280

caggatatta tttaggcatg ttcatgaatt cttttgcagt ctttcaggaa tgtggactct     2340

gggtattgac agatgcaaac ctcacgaagg attatattga tggtgtttat gacaatgcag     2400

aatatgctga gaggtttatg gaggaaaatg aaggacatat tgtagatatt catgactttt     2460

ctttgggtag cagtccacat gtccgaaagc attttccaga gacttggatt tggctagaca     2520

ccaacatggg ttacaggatt taccaagaat ttgaagtaac tgtacctgat tctatcactt     2580

cttgggtggc tactggtttt gtgatctctg aggacctggg tcttggacta acaactactc     2640

cagtggagct ccaagccttc caaccatttt tcattttttt gaatcttccc tactctgtta     2700

tcagaggtga agaatttgct ttggaaataa ctatattcaa ttatttgaaa gatgccactg     2760

aggttaaggt aatcattgag aaaagtgaca aatttgatat tctaatgact tcaaatgaaa     2820

taaatgccac aggccaccag cagacccttc tggttcccag tgaggatggg gcaactgttc     2880

tttttcccat caggccaaca catctgggag aaattcctat cacagtcaca gctctttcac     2940

ccactgcttc tgatgctgtc acccagatga ttttagtaaa ggctgaagga atagaaaaat     3000

catattcaca atccatctta ttagacttga ctgacaatag gctacagagt accctgaaaa     3060

ctttgagttt ctcatttcct cctaatacag tgactggcag tgaaagagtt cagatcactg     3120

caattggaga tgttcttggt ccttccatca atggcttagc ctcattgatt cggatgcctt     3180

atggctgtgg tgaacagaac atgataaatt ttgctccaaa tatttacatt ttggattatc     3240

tgactaaaaa gaaacaactg acagataatt tgaaagaaaa agctctttca tttatgaggc     3300

aaggttacca gagagaactt ctctatcaga gggaagatgg ctctttcagt gcttttggga     3360

attatgaccc ttctgggagc acttggttgt cagcttttgt tttaagatgt ttccttgaag     3420

ccgatcctta catagatatt gatcagaatg tgttacacag aacatacact tggcttaaag     3480

gacatcagaa atccaacggt gaattttggg atccaggaag agtgattcat agtgagcttc     3540

aaggtggcaa taaaagtcca gtaacactta cagcctatat tgtaacttct ctcctgggat     3600

atagaaagta tcagcctaac attgatgtgc aagagtctat ccattttttg gagtctgaat     3660

tcagtagagg aatttcagac aattatactc tagcccttat aacttatgca ttgtcatcag     3720

tggggagtcc taaagcgaag gaagctttga atatgctgac ttggagagca gaacaagaag     3780

gtggcatgca attctgggtg tcatcagagt ccaaactttc tgactcctgg cagccacgct     3840

ccctggatat tgaagttgca gcctatgcac tgctctcaca cttcttacaa tttcagactt     3900

ctgagggaat cccaattatg aggtggctaa gcaggcaaag aaatagcttg ggtggttttg     3960

catctactca ggataccact gtggctttaa aggctctgtc tgaatttgca gccctaatga     4020

atacagaaag gacaaatatc caagtgaccg tgacggggcc tagctcacca agtcctgtaa     4080

agtttctgat tgacacacac aaccgcttac tccttcagac agcagagctt gctgtggtac     4140

agccaacggc agttaatatt tccgcaaatg gttttggatt tgctatttgt cagctcaatg     4200

ttgtatataa tgtgaaggct tctgggtctt ctagaagacg aagatctatc caaaatcaag     4260

aagcctttga tttagatgtt gctgtaaaag aaaataaaga tgatctcaat catgtggatt     4320

tgaatgtgtg tacaagcttt tcgggcccgg gtaggagtgg catggctctt atggaagtta     4380

acctattaag tggctttatg gtgccttcag aagcaatttc tctgagcgag acagtgaaga     4440

aagtggaata tgatcatgga aaactcaacc tctatttaga ttctgtaaat gaaacccagt     4500

tttgtgttaa tattcctgct gtgagaaact ttaaagtttc aaatacccaa gatgcttcag     4560

tgtccatagt ggattactat gagccaagga gacaggcggt gagaagttac aactctgaag     4620

tgaagctgtc ctcctgtgac ctttgcagtg atgtccaggg ctgccgtcct tgtgaggatg     4680

gagcttcagg ctcccatcat cactcttcag tcatttttat tttctgtttc aagcttctgt     4740

actttatgga actttggctg tgatttattt ttaaaggact ctgtgtaaca ctaacatttc     4800

cagtagtcac atgtgattgt tttgttttcg tagaagaata ctgcttctat tttgaaaaaa     4860

gagttttttt tctttctatg gggttgcagg gatggtgtac aacaggtcct agcatgtata     4920

gctgcataga tttcttcacc tgatctttgt gtggaagatc agaatgaatg cagttgtgtg     4980

tctatatttt cccctctcaa aatcttttag aatttttttg gaggtgtttg ttttctccag     5040

aataaaggta ttactttaga ataggtattc tcctcatttt gtgaaagaaa tgaacctaga     5100

ttcttaagca ttattacaca tccatgtttg cttaaagatg gatttccctg ggaatgggag     5160

aaaacagcca gcaggaggag cttcatctgt tcccttccca cctccaacct agccctactg     5220

cccaccccac cccaacccac cccatgccca gtggtctcag tagatacttc ttaactggaa     5280

attctttctt ttcagaatct aggtggtgaa ttttttttaa gtggcacggt ctttttctgc     5340

ttgaaatctg atcacacccc ccagccattg ccctccctct ctttttcctc tgtagagaaa     5400

tgtgaggggc agtacattta ctgtgctttt cacaccatct cagaggttga ggagcatact     5460

gaaaattgcc ctggggggtg ctgggtgtgc tgtctccttc ccacatcctc agccccacac     5520

cagctctatt tcaggggtga gagtcagaga gcactgcaat atgtgcttca tgggatttcg     5580

attcgaagat cctagaccag ggagacactg tgagccaggg atacaacaaa atactaggta     5640

agtcactgca gaccgacctc cctgcagttt gggaaagaag ctgggtttgt ggagaatcag     5700

agcatcttga catgactgct gacctaaaga tccctggcat tggccaggga tcctgtggaa     5760

cctcttctag ttcaggggtg tgagcattag actgccagtt gtctagtgac atctgatgct     5820

tgctgtgaac ttttaagatc cccgaatcct gagcacctca atctttaatt gccctgtatt     5880

ccgaagggta atataattta tctggatgga aattttaaag atgaatcccc cttttttctt     5940

ttcttctctc ttttctttcc ttctcccttt cttctttgcc ttctaaatat actgaaatga     6000

tttagatatg tgtcaacaat taatgatctt ttattcaatc taagaaatgg tttagttttt     6060

ctctttagct ctatggcatt tcactcaagt ggacagggga aaaagtaatt gccatgggct     6120

ccaaagaatt tgctttatgt ttttagctat ttaaaaataa atccatcaaa aataaagtat     6180

gcaaatgtat cttttaaagt taatttttaa aaatgctctt attttagtga attttcagaa     6240

attatagtgg aatggatgct catatattgc ttatggatat tttggatacc aaagtaggaa     6300

taactgacat tcagtatttt aaagctggca aacctgtaca tagaaaatag atccccagac     6360

agtggtctat gaagagggca gttaagtatc aaatacttaa ttttcttgcc tttttttctt     6420

aagtggggaa aagtttctag atctcttaca cctctgacac aatctgttct aaaacaggca     6480

cttgtaatgt tggggcctcc ttgtaaacgt gtttttgccc tttactctct gggagttctt     6540

taaaggtgaa atcatcttac aaagaaattg ggggagggtc ttggcaaagg actttcccct     6600

cctctttcct ggcctgggaa ccttatactg acaatcaata ctttatattt taaagtatat     6660

aatttatagt taacttctag tgtaatatat taggaaacac tagaatggaa aggccattgg     6720

aagacaggtt gtatcttttt tagaccatat ttccttgttt aaaaactatc atttgaatac     6780

ttttttggtg aagaactcca tgttttcaag ttaaaggtca cctcgtaggc caggcgcagt     6840

ggctcatgcc tgtaatccca gcactctggg aggctgaggc gggtgaatca caaggttagg     6900

agtttgagac cagcctggcc aatatggtga aaccccgtcc ctactaaaaa tacaaaattt     6960

agccaggcgt ggtggcatgc acctgtagtc ccacctactc gggaggctga ggcaggagaa     7020

tcacttgaac ctgagagaca gaggttgcag tgagccgaga tcacgccact gcactccagc     7080

ctgggggaca gagtgagatt ctgtctcaaa aaacaaaaaa caaaaaagtc accttgtaac     7140

tcatctcttt ttattgtaag tttattaaaa atgaagagga caacaatgag aaggaacata     7200

aagggttagc tagcactgtc tcctggtgca tggggctgtg cagatgtccc ggccacttct     7260

tccttcatac ttcccttaga gaacttgctc tgctacaagc agtgggcttg gactaaaagt     7320

gattaaaata ccacaggcat aaggagaaaa ggagtatatg tagtagtaat aattactagt     7380

ataaattatt ttcttcacat gctatgagta ataatattaa aaaactcatt ttaccattaa     7440

gattccttat gctgaagctc ttccatttag aatactgtca atgtcattta ctggtatgaa     7500

ctaaagtccc ccttcttttc cactcactgg gaaccttagt aaaacaccag catatcttac     7560

ctctctttct gactggccga tgcttccaga gactgaatgt tgggaaaacc tagtagccaa     7620

acaattctag gacagaataa catttttata tttggttcca ccatcttatt acatttagtt     7680

atagttttaa aaaagaaatt caagcccatt aaaatatgtc tggtcaatga aatgcttcct     7740

tttattgtgt tgtgctattg tactttgttt ttcaaaacat tgtaaaaata gtatctttgg     7800

tttagtattt tggattatat attataatct gaggagtgtt ttgcttatgt agaatccaga     7860

tatatttctg ttacctagga gatgttactt acatatgtaa tactgtatcc tgcacgtgga     7920

aatattcaga attgtagata gcataactct ccctgctcct attcttttga gcctaggtat     7980

aatttttttt ttttttttag aaaaagacat atttagcttt aatttctatt tatgctaaac     8040

atatttataa gtagtctgtc aatataatac caactatttt tatttttaca taattcaatt     8100

atttcatttg acatgtctgg cagactcaag acattaagta aaaaattgga actatgattt     8160

ttctttgtca ttttttaaaa aagaattatt ttattaacct gctggcatat aatctggagt     8220

tcttttcaca accttacttt ttctgatttg ctttattgaa tgattgaata ctcatttctt     8280

tctaaaaata tgttgtaaat tctcccttgg caagatttct ccctatgagg gtagttatta     8340

tttgagtctg ccaagtggtt accatggggc aaggtgccat gatgtattct tgggtgcatt     8400

ggttttttgc gcattgtaaa tttaagacac ttatagtaag tggactcatt catagatgag     8460

tttcagaacc ttttacgttc tcggtagagg cttctgtcgg acaggcagaa gagtgtattc     8520

ctcacttttt tttttgtctt caaattccag taaggcatag cacttttaag aaattagaat     8580

ttttctatca tctatgcaaa tgatatttat gttaatatta aatatcttat gttacactgg     8640

gagtaatttg aggtgcaatt atttttatta ctactttgaa tagaggacca ttatccttct     8700

ttcttcagaa aactaagaag taagtgtaac ttttaaagta agtatatatc agtgagagta     8760

ggcttgtttt acaactattt ctagccagtg agttgtgttt tcatgtctca tcaaaagaca     8820

ataccacatt gcatcatttt acaaaatatg ttgtcatttt catttcagtt gtaacatagg     8880

aaaatagata tttcctagat gatttctgag tttcttactg caaagaacag ttataaattg     8940

gtatacatgt gtctctgtaa tagggataat attgatatat ctgttgctac atatttaaga     9000

atcattctat cttatgttgt cttgaggcca agatttacca cgtttgccca gtgtattgaa     9060

ttggtggtag aaggtagttc catgttccat ttgtagatct ttaagatttt atctttgata     9120

actttaatag aatgtggctc agttctggtc cttcaagcct gtatggtttg gattttcagt     9180

aggggacagt tgatgtggag tcaatctctt tggtacacag gaagctttat aaaatttcat     9240

tcacgaatct cttattttgg gaagctgttt tgcatatgag aagaacactg ttgaaataag     9300

gaactaaagc tttatatatt gatcaaggtg attctgaaag ttttaatttt taatgttgta     9360

atgttatgtt attgttaatt gtactttatt atgtattcaa tagaaaatca tgatttatta     9420

ataaaagctt aaattctcat ctatttaaaa aaaaaaaaaa aaaa                      9464


<210>  14
<211>  2562
<212>  DNA
<213>  Homo sapiens

<400>  14
gagatcttgc cattgcactc cagcctgggc aacaagagcg aaactccatc tcaaggaaaa       60

acaacaacaa caacaacaaa atcctgggct ctgcttcaga ctagttaaac cagaatctcc      120

agggtggggc accggaaaga acaagaaaaa agaacacctt atttttatct tcttcagtga      180

gccaatgttc attcaaaaga gagattaaag tgctttttgc tgactagtca cagtcagagt      240

cagaatcaca ggtggattag tagggagtgt tataaaagcc ttgaagtgaa agcccgcagt      300

tgtcttacta agaagagaag ccttcaatgg atccagctgt ggctctggtg ctctgtctct      360

cctgtttgtt tctcctttca ctctggaggc agagctctgg aagagggagg ctcccgtctg      420

gccccactcc tctcccgatt attggaaata tcctgcagtt agatgttaag gacatgagca      480

aatccttaac caatttctca aaagtctatg gccctgtgtt cactgtgtat tttggcctga      540

agcccattgt ggtgttgcat ggatatgaag cagtgaagga ggccctgatt gatcatggag      600

aggagttttc tggaagagga agttttccag tggctgaaaa agttaacaaa ggacttggaa      660

tccttttcag caatggaaag agatggaagg agatccggcg tttctgcctc atgactctgc      720

ggaattttgg gatggggaag aggagcatcg aggaccgtgt tcaagaggaa gcccgctgcc      780

ttgtggagga gttgagaaaa accaatgcct caccctgtga tcccactttc atcctgggct      840

gtgctccctg caatgtgatc tgctctgtta ttttccatga tcgatttgat tataaagatc      900

agaggtttct taacttgatg gaaaaattca atgaaaacct caggattctg agctctccat      960

ggatccaggt ctgcaataat ttccctgctc tcatcgatta tctcccagga agtcataata     1020

aaatagctga aaattttgct tacattaaaa gttatgtatt ggagagaata aaagaacatc     1080

aagaatccct ggacatgaac agtgctcggg actttattga ttgtttcctg atcaaaatgg     1140

aacaggaaaa gcacaatcaa cagtctgaat ttactgttga aagcttgata gccactgtaa     1200

ctgatatgtt tggggctgga acagagacaa cgagcaccac tctgagatat ggactcctgc     1260

tcctgctgaa gtacccagag gtcacagcta aagtccagga agagattgaa tgtgtagttg     1320

gcagaaaccg gagcccctgt atgcaggaca ggagtcacat gccctacaca gatgctgtgg     1380

tgcacgagat ccagagatac attgacctcc tccccaccaa cctgccccat gcagtgacct     1440

gtgatgttaa attcaaaaac tacctcatcc ccaagggcac gaccataata acatccctga     1500

cttctgtgct gcacaatgac aaagaattcc ccaacccaga gatgtttgac cctggccact     1560

ttctggataa gagtggcaac tttaagaaaa gtgactactt catgcctttc tcagcaggaa     1620

aacggatgtg tatgggagag ggcctggccc gcatggagct gtttttattc ctgaccacca     1680

ttttgcagaa ctttaacctg aaatctcagg ttgacccaaa ggatattgac atcaccccca     1740

ttgccaatgc atttggtcgt gtgccaccct tgtaccagct ctgcttcatt cctgtctgaa     1800

gaagggcaga tagtttggct gctcctgtgc tgtcacctgc aattctccct tatcagggcc     1860

attggcctct cccttctctc tgtgagggat attttctctg acttgtcaat ccacatcttc     1920

ccattccctc aagatccaat gaacatccaa cctccattaa agagagtttc ttgggtcact     1980

tcctaaatat atctgctatt ctccatactc tgtatcactt gtattgacca ccacatatgc     2040

taatacctat ctactgctga gttgtcagta tgttatcact agaaaacaaa gaaaaatgat     2100

taataaatga caattcagag ccatttattc tctgcatgct ctagataaaa atgattatta     2160

tttactgggt cagttcttag atttctttct tttgagtaaa atgaaagtaa gaaatgaaag     2220

aaaatagaat gtgaagaggc tgtgctggcc ctcatagtgt taagcacaaa aagggagaaa     2280

ggtaagaggg taggaaagct gttttagcta aatgccacct agagttattg gaggtctgaa     2340

tttggaaaaa aaaactatgt ccaggagcag ctgtaacctg tagggaaata ctggaacaat     2400

catccataag agggatgaac attaagtgtt tgaattcatg ctctgctttt gtgttactgt     2460

aaacacaaga tcaagatttg gataatcttt ttcctttgtg tttccaactt agatcatgtc     2520

taaatatatg ctttcatatg gctaaaaaaa aaaaaaaaaa aa                        2562


<210>  15
<211>  12602
<212>  DNA
<213>  Homo sapiens

<400>  15
ggagggagca gtcggtcgct gcgccccggc gggccacttt cccgggaccc cgctcgtctt       60

ccttgggccg agattttcca ctgcgcccct ccgagtaccc gggttccaaa cccctagcca      120

cgacatggaa gaatttttgc aacgcgccaa atctaaactg aatcgaagca aacgcttgga      180

gaaggtccat gtggttattg ggcctaaatc gtgtgacttg gattctctca tttctacctt      240

cacatatgct tactttctag acaaggtcag tccaccaggg gttctgtgtt taccagtgct      300

gaacatacca agaactgaat tcaactactt caccgagacg aggtttattt tagaagagct      360

aaatatttcc gaatcattcc acatattccg ggatgaaatt aacctgcatc agctaaatga      420

tgaagggaag ttatcgataa cacttgttgg cagcagtgtg ctggcgagtg aagacaaaac      480

tttagaatca gcagttgtca aagtcattaa tccggttgag cagagcgatg ccaacgttga      540

gttccgagag tcttcctctt ctctcgtgct aaaggagatt ctccaagagg ctcctgagct      600

catcaccgag caactggctc atcgcctcag aggtagcatt cttttcaagt ggatgaccat      660

ggaatcagag aagatctcag agaagcagga ggaaattctt tctatcctgg aagaaaaatt      720

tcctaacttg cctccaagag aggacatcat caacgtccta caggagaccc agttcagtgc      780

tcagggttta agtattgaac agacaatgtt gaaagatcta aaggagctgt cagatggaga      840

aataaaagtg gccattagta ctgtgagcat gaaccttgag aattgtctat ttcacagcaa      900

tattaccagt gacttgaaag catttacaga caagtttggt tttgatgtcc tcatcctgtt      960

ctccagctat ctgtcagagg agcagcagcc gagacgacag attgctgtgt actcagaaaa     1020

catggagctg tgcagtcaga tttgctgtga gctggaagag tgtcagaacc cttgcctaga     1080

actggagccc tttgactgtg gctgtgatga gatcctggtg taccaacaag aggacccttc     1140

agtgacttgt gatcaggtgg ttctcgttgt caaggaagtc atcaacagga ggtgtccaga     1200

gatggtctcc aatagccgga catcctcaac agaagccgtg gcaggcagtg cccccctctc     1260

ccaggggtct tctgggatta tggaattgta tggttctgac atagagccac aacccagctc     1320

tgtgaatttc atagagaacc ctccagatct caatgattct aaccaggctc aggtggatgc     1380

caatgtagac cttgttagcc cagacagcgg actggctacc attaggagca gccgctcatc     1440

caaggagagc tctgttttcc tcagtgacga cagccccgtg ggagaaggtg ctgggcctca     1500

ccacaccctt ctcccagggc ttgactccta cagccccatc cctgaagggg cggtggcgga     1560

ggaacatgca tggtctggag aacacggtga gcacttcgac ctcttcaatt ttgacccagc     1620

acccatggct tctgggcagt cccagcaatc ttctcattct gcagactact ccccagcaga     1680

tgacttcttc cccaacagtg acctgtcaga aggacagctc cccgctgggc ctgaaggact     1740

tgatggcatg ggaaccaaca tgtctaatta ttcatccagt tcacttttgt caggggctgg     1800

caaagatagc cttgtggaac atgatgagga gtttgtccag agacaagaca gtcccagaga     1860

taactctgaa agaaatttga gcctgacaga ttttgtggga gatgaatccc cttccccaga     1920

aaggctaaaa aatactggaa agaggatccc accaacaccc atgaatagtt tagtagaaag     1980

ctcgccatcc actgaagaac cagcctcact ctatacagaa gatatgaccc aaaaagcaac     2040

tgacacaggt cacatggggc cacctcagac ccatgcacgg tgcagcagct ggtggggtgg     2100

tttggaaatt gactccaaaa atattgcaga tgcgtggagt tccagtgaac aggaatctgt     2160

tttccagagc cctgaatcat ggaaagagca taagccaagc tccattgata ggagagcctc     2220

agattctgta tttcaaccaa agagcctcga atttacaaag tcaggtccct gggagtctga     2280

atttggtcag cctgaactgg gtagcaatga tattcaagac aaaaatgagg aaagcttgcc     2340

gttccagaac ctgcccatgg agaagtcacc tttgccaaat acatctcccc aaggaacaaa     2400

ccacctgata gaagactttg cttctttgtg gcattctggt cgctctccca cagccatgcc     2460

cgagccctgg ggaaatccta cagatgatgg tgaaccagca gctgtggcgc cattcccagc     2520

ctggagtgca tttggtaaag aagatcatga tgaagcttta aaaaatacct ggaatttgca     2580

cccaacaagc agcaagacac cttctgttag ggacccgaat gagtgggcca tggcaaaaag     2640

tgggtttgcc ttttcttctt cagaactact ggacaattca cccagtgaga taaacaatga     2700

agcagctcca gaaatctggg gcaagaaaaa caatgactcc agggatcaca tctttgcacc     2760

tggaaatccc agttctgatc tggatcacac atggactaat tctaagccac caaaagaaga     2820

tcagaatggt ttagtggatc ctaaaactag gggcaaggta tatgaaaagg tagattcctg     2880

gaaccttttt gaggagaata tgaagaaagg agggtcagat gtcctagttc cttgggaaga     2940

ttccttctta tcttacaaat gttctgatta cagtgcatcc aacctaggag aagattcggt     3000

gccttccccc ttagatacca attattccac ctcagactct tacacatcac caacatttgc     3060

tggagacgaa aaggaaactg aacacaagcc atttgctaaa gaggaaggtt ttgagtcaaa     3120

agatggtaac tccacggcag aggagactga cattcctcct cagtcactgc aacagtcatc     3180

tcgaaatcga atcagttcag gtcctgggaa cctagacatg tgggcttcac ctcatacaga     3240

taacagttct gaaataaata ccactcacaa cctggatgaa aatgaactca agacagagca     3300

cacagatggt aagaatatct ccatggagga tgacgtcggg gaaagcagcc agtccagtta     3360

cgacgacccc agcatgatgc aactgtacaa tgaaacaaac cgacaactca cacttttgca     3420

cagcagcacc aactcccggc agacggcccc tgacagtctc gacttgtgga acagagtgat     3480

tttggaggat actcagtcca ctgcaacgat ctcagatatg gacaatgatt tggactggga     3540

tgactgcagt gggggtgcgg caatccccag tgatggtcaa acagaaggat acatggctga     3600

aggttccgag ccggaaaccc gatttacagt gagacagctg gaaccctggg gcttggagta     3660

tcaggaagca aatcaggtag attgggagct ccctgcctct gatgagcata ccaaggacag     3720

tgctcccagt gaacatcaca cattgaatga gaaaagtggg cagctaattg caaacagtat     3780

ttgggattct gtcatgagag ataaagacat gtcatcattc atgttaccag gctcctcaca     3840

tatcacagat tcagagcaaa gggaattgcc tcctgaaatc cccagccatt cagcaaatgt     3900

taaagacact cattccccag atgcgccagc agcctctgga accagtgaat cagaggcact     3960

tatatctcat cttgacaagc aggacacaga gagggaaacc ctgcaaagtg atgcagcatc     4020

cttggcgact aggcttgaga atccagggta ttttccacac ccagatccat ggaaaggtca     4080

tggcgatgga caaagtgaaa gtgagaagga agcccaggga gccactgaca gggggcacct     4140

tgatgaagag gaggtgatcg cctctggtgt ggagaatgcc tcagggattt ctgaaaaagg     4200

gcagagtgac caggaactgt cttctctggt tgcatctgaa catcaggaaa tctgcattaa     4260

atcaggcaaa atcagctctc ttgctgtcac tttcagtcct caaaccgagg aaccagagga     4320

agttttagag tatgaggagg ggtcttacaa tctagactcc cgtgatgtgc aaacagggat     4380

gtccgcagat aacctgcagc caaaagatac ccatgaaaaa cacctcatga gtcaaagaaa     4440

ttcaggtgaa actactgaga cttcagatgg gatgaatttc acaaaatatg tatctgtacc     4500

tgaaaaggat cttgagaaaa ctgaagaatg taactttcta gagccagaga acgtgggtgg     4560

agggccacct cacagagttc cccgaagtct tgattttggg gacgtcccta tagacagtga     4620

tgtgcatgtc agcagcacat gttctgagat aaccaaaaat cttgacgtta aggggtctga     4680

aaatagcctt ccaggagccg gttcgtctgg aaattttgac agagatacta tttctagtga     4740

gtatactcat tcaagtgcat caagtcctga gttaaatgac tcttcagttg cactgtcctc     4800

ctggggccag caacccagtt ctgggtatca agaagaaaac caaggcaact ggagtgaaca     4860

gaatcaccaa gaatctgaac taattaccac tgatggccaa gtagaaatag ttaccaaagt     4920

gaaggattta gagaaaaaca gaataaatga gtttgaaaag agctttgatc gcaaaactcc     4980

tacattttta gagatctgga atgactcagt tgatggtgat tccttttcct ctttatccag     5040

tcctgaaaca ggcaaatatt ctgaacattc agggacacat caggaaagca atctaattgc     5100

tagctaccag gagaaaaatg aacatgacat ttctgcaact gtgcagccag aggatgccag     5160

ggtcatttca acaagctcag gttctgatga tgacagtgtc ggtggtgaag agtcaataga     5220

ggaagagatc caggtggcca actgccacgt tgctgaggat gaatccagag cttgggattc     5280

attgaatgaa tctaataagt tcttggtcac agctgatcct aagtctgaaa atatttatga     5340

ctacctagac agctcagagc cagcagagaa tgagaataag tcaaacccat tctgtgacaa     5400

tcaacaaagc agccctgatc cctggacttt ctcaccatta acggagactg aaatgcagat     5460

tacagcagtg gagaaggaga agagatcttc tccagaaaca gggacaacag gagatgttgc     5520

atggcaaata tctcccaaag cttcgttccc aaagaacgaa gataattctc aactggaaat     5580

gctgggcttc tcagctgata gcactgagtg gtggaaggcc tcaccccagg aagggagact     5640

aattgaaagt ccatttgaaa gggagctgtc tgactccagt ggtgtgttgg agataaattc     5700

ttcagtacac caaaatgcca gtccctgggg agtaccagtt cagggtgata ttgagcccgt     5760

ggaaacacac tatactaatc cttttagtga caaccatcag tcaccctttc tggaaggtaa     5820

tgggaagaac tcccatgagc aactctggaa cattcaacca aggcagccag acccagatgc     5880

tgacaagttc agccagcttg taaaattaga ccaaattaaa gaaaaggact caagagagca     5940

aacctttgtg tctgctgctg gtgatgagct gactcctgaa acacctaccc aagagcagtg     6000

tcaggacacc atgctgccag tctgtgatca tccggacaca gcctttactc acgcagagga     6060

aaatagttgt gttacatcta atgtttcaac taatgaaggt caagaaacaa atcagtggga     6120

acaagaaaaa tcatacctag gtgagatgac aaattcaagc attgccacag aaaattttcc     6180

tgctgtcagt tctcccaccc aactgataat gaagccaggc tctgaatggg atggctctac     6240

cccaagtgag gactcccgag gtacctttgt gccagatatt ttacatggca actttcaaga     6300

gggtgggcag ctggcctctg ccgcgcctga cttgtggata gatgctaaga agcccttcag     6360

tttgaaagca gatggtgaga atcctgatat cctgacgcac tgcgaacatg acagcaattc     6420

tcaggcttcc gacagccctg atatatgtca cgattctgaa gcaaagcaag agactgagaa     6480

gcacctcagt gcttgcatgg gacctgaagt ggaatccagt gagctttgtc tcactgagcc     6540

agagatagat gaagaaccca tttatgagcc tggacgggag tttgtcccat ccaatgcaga     6600

actcgattct gaaaacgcaa ctgtgctgcc tccaattggc tatcaagcag acataaaggg     6660

ctcctctcag cccgcctctc ataaaggttc acctgaacct tctgaaataa acggtgacaa     6720

cagtacaggt ttacaagtat cagaaaaagg agccagccca gatatggcac caattttgga     6780

accagttgac agaagaatcc caaggattga aaatgtggca actagcattt ttgtaactca     6840

ccaagagcca actccagaag gtgacggttc ttggatatca gacagctttt ctcctgaaag     6900

tcagcctggt gcaagagctt tgtttgatgg tgatccacat ttatccacag agaatcctgc     6960

cttggttcct gatgctttgc tagcctcaga cacttgtctg gatataagcg aagctgcctt     7020

tgaccacagt ttcagcgatg cctcaggtct caacacatcc acgggaacaa tagatgacat     7080

gagtaaactg acattatccg aaggccatcc ggaaacgcca gttgatgggg acctagggaa     7140

gcaagatatc tgctcatctg aagcctcgtg gggtgatttt gaatatgatg taatgggcca     7200

gaatatcgat gaagatttac tgagagagcc tgaacacttc ctgtatggtg gtgaccctcc     7260

tttggaggaa gattctctga agcagtcgct ggcaccgtac acacctccct ttgatttgtc     7320

ttatctcaca gaacctgccc agagtgctga aacaatagag gaagctgggt ctccagagga     7380

tgaatctctg ggatgcagag cagcagagat agtgctttct gcacttcctg atcgaagaag     7440

tgagggaaac caggctgaga ccaaaaacag actgcctgga tcccagctgg ctgtgctgca     7500

tattcgtgaa gaccctgagt ccgtttattt gccggtagga gcaggctcca acattttgtc     7560

tccatcaaac gttgactggg aagtagaaac agataattct gatttaccag caggtggaga     7620

cataggacca ccaaatggtg ccagcaagga aatatcagaa ttggaagaag aaaaaacaat     7680

tcctaccaaa gagcctgagc agataaaatc agaatacaag gaagaaagat gtacagagaa     7740

gaatgaagat cgtcatgcac tacacatgga ttacatactt gtaaaccgtg aagaaaattc     7800

acactcaaag ccagagacct gtgaagaaag agaaagcata gctgaattag aattgtatgt     7860

aggttccaaa gaaacagggc tgcagggaac tcagttagca agcttcccag acacatgtca     7920

gccagcctcc ttaaatgaaa gaaaaggtct ctctgcagag aaaatgtctt ctaaaagcga     7980

tacgagatca tcttttgaaa gccctgcaca agaccagagt tggatgttct tgggccatag     8040

tgaggttggt gatccatcac tggatgccag ggactcaggg cctgggtggt ctggcaagac     8100

tgtggagccg ttctctgaac tcggcttggg tgagggtccc cagctgcaga ttctggaaga     8160

aatgaagcct ctagaatctt tggcactaga ggaagcctct ggtccagtca gccaatcaca     8220

gaagagtaag agccgaggca gggctggccc ggatgcagtt acgttgcagg ctgtcaccca     8280

tgacaatgaa tgggaaatgc tttcaccaca gcctgttcag aaaaacatga tccctgacac     8340

ggaaatggag gaggagacag agttccttga gctcggaacc aggatatcaa gaccaaatgg     8400

actactgtca gaggatgtag gaatggacat cccctttgaa gagggcgtgc tgagtcccag     8460

tgctgcagac atgaggcctg aacctcctaa ttctctggat cttaatgaca ctcatcctcg     8520

gagaatcaag ctcacagccc caaatatcaa tctttctctg gaccaaagtg aaggatctat     8580

tctctctgat gataacttgg acagtccaga tgaaattgac atcaatgtgg atgaacttga     8640

tacccccgat gaagcagatt cttttgagta cactggccat gatcccacag ccaacaaaga     8700

ttctggccaa gagtcagagt ctattccaga atatacggcc gaagaggaac gggaggacaa     8760

ccggctttgg aggacagtgg tcattggaga acaagagcag cgcattgaca tgaaggtcat     8820

cgagccctac aggagagtca tttctcacgg aggatactat ggggacggtc taaatgccat     8880

cattgtgttt gccgcctgtt ttctgccaga cagcagtcgg gcggattacc actatgtcat     8940

ggaaaatctt ttcctatatg taataagtac tttagagttg atggtagctg aagactatat     9000

gattgtgtac ttgaatggtg caaccccaag aaggaggatg ccagggctag gctggatgaa     9060

gaaatgctac cagatgattg acagacggtt gaggaagaat ttgaaatcat tcatcattgt     9120

tcatccatct tggttcatca gaacaatcct tgctgtgaca cgacctttta taagttcaaa     9180

attcagcagt aaaattaaat atgtcaatag cttatcagaa ctcagtgggc tgatcccaat     9240

ggattgcatc cacattccag agagcatcat caaactggat gaagaactga gggaagcatc     9300

agaggcagct aaaactagct gcctttacaa tgatccagaa atgtcttcta tggagaagga     9360

tattgacttg aagctgaaag aaaagcctta gttggccatg ctggaagaag aggatgcttt     9420

tctggttcat ggttctgttg aaacatatct acctgaaaga gacagggctg atgttacctt     9480

tttccacttt gcactacctg gtgccattct aaatttctaa ggggaaaaat agaaagtttg     9540

tttactctta agatatttta tgaaattgtg tgtactttcc tattttgcca attatgtgcc     9600

tcaaagattt tagttgagcc ttagcaagaa agtaggacct tccatttcaa tacttcatta     9660

acacggtgta gtgatacttt gtcccttaga ctggtgttta ccagtaagat acctttaatc     9720

cactgttaag tatgagtgga tttgtttcca tagattagct ggatttcctt ttggtgattg     9780

cattaggttt aaagtacaca ggtctcaact ctccccagga aagtttcccc tgtttgactc     9840

cacctttaaa atcctaagcc tgactaggac agccacaaac cacacaaggt gtaaaaccat     9900

catcagctaa gtgcccgttt tgttcttgtt taccagaatc tcctttaact tctcaaaggg     9960

aagccgggct ttctaatcca cgtcaacttt attttagttg tcaaattggg cattatattt    10020

tatgtaaatt ggtcttttaa catcattttc ctgatgaatg ttggtgacca ccacattgtg    10080

aaatttaaga atccgtgttg catgtttggt agctctctga gtttcaggcc ataaactcag    10140

ctccagaggt taccttttaa gtgccaagaa ctcaagtgca aggtggccta ctcaaaaatc    10200

atttggtagc attcagttat tcatgaattc ctctctcgca tgcattataa aaagtgatct    10260

gctttaaaac accgtaatct gatcataggc ttaaaattaa atatgagtat tactttcatg    10320

tacaaaatat ttcctttata gtcttcatat gccctttaaa atgccaacaa gatttcaagt    10380

ctgtaggcct ctagtgaggt ggggtggcaa accacagcta agtctcgctc accactgcaa    10440

gctaagaatg gtttttacat tttgggttgg aaaaattttt tttgaatatt tcatgacaca    10500

tgaaaattat tcaaatgtta gtgccgataa ataaagtggt actgaaacac agccacacaa    10560

acttgttttt gtactgtcta cagctacttt cacactacag ccgcagagct gagcagttca    10620

gcagaccgta tgtcccacaa tgcctaaaac attgactatg tttacagaaa aagtttgctg    10680

acccctgctc tagcaaacgc atcctttcct actccacccc aatttgtatt tagatagttt    10740

ctctaacaga acggacaaat gaggctgcaa actaatttat ttttgtcaaa aatcaatgtt    10800

ttgacatcca cagacagtga aataaaagaa atggcttgct gaaaaacatg aggagtccta    10860

gccacaaaat cactgcttag gttgcaattg ccaaaatgaa gccttcttag aagcacttct    10920

ttagtatata caggtgttgg ctgaagtccg tgcctcactc tgggaaccat tcttagtctc    10980

cagtgtctcc tattacaaag aagctggcag aaataaaaat gaaggggtga gagcggttcc    11040

accctagtct catggtggaa aattcattgg ggagagctgt ccaggatatt tggagtcctg    11100

ggtagaagga gcttgtaact actttaaagt cgacatcttt gcacaggtga ttgagtttct    11160

ctgacctcat tgcttcacct ctgtctcctc ccgtccttcc gcacgtgccc acacacacgc    11220

agttcagccc tctttcctcc ataagcctcc atcgttttct cttttctcct cttgatcctt    11280

tcaagcgagt atcttgttga attgtatgtt ctgttggatc tcctccttca taacatctgg    11340

cttgttggac agaaaaaccc tacagcccac cccctcccac agcccacctc cacttttgaa    11400

agcccaaatt acacctctcc cagaacacag tgttgacgta aatacagtta cccaatattc    11460

ctgtttgttc acctatttgc tactttcact cagtagcatc ccattttgta aaatgaattc    11520

catggtcacc ctgtcacagg aagtaatgaa aaatccagtg ttcagtgtag tggtgcaaac    11580

ctgagggcat agagctgttc atagagggct cttgttatag ccaaacagac acagcaacaa    11640

tctcaccatt tatatatata tttttaactt gtccagctca tctatggaaa actactcagg    11700

tggtatgctg tttgaagcct catcttccta catgaaaatt atgggcattt gtcccaatga    11760

ttttgtttca gctgttctgt aggctgcata accactctga tatttaggta tctgctattt    11820

tattatctta aaagacaaat taatttaatt gcatgtgcta gggaaaagct accatgtaca    11880

ttcaccccaa gtaaatagaa tcctagatga atcctagaaa aataatccct aagcagatag    11940

gtagacagag gtaaacattc acatgattta gctctctagc tcttgcactc tgaacattct    12000

tgctttggtt ctgacttctg ggaactgctt tgcatttctc ctatagatct gtagttaagg    12060

gaaccaaggg gtcattgggg caaaagcatt gtttctcaaa gctccttgat taagagaaag    12120

aacagaaatt tgcacagaag atagtgtcaa ggagtgagaa agtttgtttg agggcagtag    12180

ctcagtgtgg aagaaaatcc tgaagtttct gttgaagcca tacaatgttc tatggggtta    12240

ctctctaaga cattctctga ggtgtgtgag gaagtcacta ctcctagcct ttgttaagat    12300

gtaattttaa atattcagtt atggtactat gtttgcaact ctcgtcttat cacaatgcct    12360

cagtagtttg ttcccttaga aacatttaga tgtgcacaaa ttaatctttt atatatctaa    12420

aggtttttct atcatgcatt ggattgctca gaataaagtg tctgttagac ttcgttttgg    12480

taaataaatt ctccataatg tagattaata atataaaagt ctttaatgac acaatatatc    12540

tatatagcct cactgtataa ttcagaaata aaaattgatt ctgcaaaaaa aaaaaaaaaa    12600

aa                                                                   12602


<210>  16
<211>  3286
<212>  DNA
<213>  Homo sapiens

<400>  16
gaacaaaacc tgcccagagc gctccctgtg tagattcgct ggaagcagct ggaggctcca       60

gttctcatct gctcaggtgt ccccggcgcc ttggcgaact cggccactcc agttcctcac      120

gtggtgagca ctcagggcag cgggtcgatt ttccgaggtc ccatacctgg gtttgagggg      180

cgcggctcgc agcggcgggt gcaggggcga ctgccagccc tcaccccgcc tcggggtgcg      240

ttcggaggcc gacacctgga ggacgcctcc agtccccgcg ggacgccacg cctgcgcgcc      300

agggatccgg gataagaagt gcgcgccggg ctccggctgc gcgccgcggg gccaccagtt      360

tgcgcgcagg gctcaggcga ccgtgcggcc atggacacgc cacggggcat cggcaccttc      420

gtggtgtggg actacgtggt gttcgcgggc atgctggtca tctcggccgc catcggcatc      480

tactacgcct tcgctggggg cggccagcag acctccaagg acttcctgat gggcggccgc      540

agaatgaccg cagtgcccgt ggcgctgtcc ctcaccgcta gcttcatgtc agccgtcact      600

gtcctgggca ccccctccga ggtctaccgt tttggggcca tttttagcat ctttgccttc      660

acctacttct ttgtggtggt catcagcgcg gaggtcttcc tcccggtgtt ctacaaactg      720

ggaattacca gcacctacga gtatttagaa cttcgattta acaaatgtgt tcgtctctgt      780

ggaacagtcc tcttcattgt tcaaacaatt ctgtatactg gaattgttat ttatgcccct      840

gccctggctt tgaatcaagt cacaggattt gatctgtggg gcgcggtagt ggcaacgggg      900

gtggtctgca cattctactg cacactgggt ggtcttaaag cagttatctg gacagatgtt      960

tttcaagttg ggatcatggt ggctggattt gcatccgtga ttatacaggc tgtggtgatg     1020

caaggtggaa tcagcactat tttaaatgat gcctatgatg gtggaagatt aaatttctgg     1080

aattttaatc ctaacccttt gcaaagacac accttctgga caattattat aggagggacc     1140

ttcacatgga ccagcatcta cggtgtcaac caatcccagg tgcagagata tatttcttgt     1200

aaaagcagat tccaggcaaa actgtctctc tacatcaatc ttgtgggact ctgggcaatc     1260

ctcacatgct cagtgttttg tgggctcgcc ctatattcca ggtaccatga ctgtgatcct     1320

tggacagcca agaaagtgtc tgcaccagac cagctcatgc cttatttggt actggacatt     1380

ctgcaagatt atccaggact tcctggactt tttgtggcct gtgcttacag tgggacatta     1440

agcacagtgt cctccagtat taatgcctta gcagcagtaa ctgtggaaga tctaatcaaa     1500

ccttacttca gatcgctctc agaaaggtct ctgtcttgga tttcccaagg aatgagtgtg     1560

gtgtatggag ccctgtgtat tggaatggct gcgctggcgt cacttatggg agctttgttg     1620

caggcagcac tcagcgtatt tggtatggtt ggtggaccac ttatgggcct gttcgctttg     1680

ggcattttgg ttccctttgc caactcaatt ggagcacttg ttggtctgat ggctggattt     1740

gccatttctc tatgggttgg aattggagct caaatatatc ctccacttcc tgagagaaca     1800

ttgccattgc accttgatat ccaaggctgt aacagcacct acaatgagac aaatttgatg     1860

acaaccacag aaatgccatt tactactagt gtttttcaaa tatacaatgt tcaaaggact     1920

ccactgatgg ataactggta ttctttatca tatctgtact tcagcactgt tggaactttg     1980

gtaacattat tagtggggat acttgtcagt ttatcaacag gaggaagaaa acagaactta     2040

gaccccagat acatactaac caaagaggac tttttatcca attttgatat ttttaagaaa     2100

aagaagcatg ttttgagcta taaatcacat ccagtggaag atggtggaac tgataatcct     2160

gctttcaacc acattgaatt gaactcagat cagagtggca agagcaatgg gactcgtttg     2220

tgaagctgct ctgatactag atatccttaa atgatgtttc aattttatat gttttctaag     2280

ataattggat caggttttct ttgtgtgtgt gtgtgtgttg tatcatgagt gtttggggga     2340

taagtttttg ttaaaacaaa gtctggacta tcttcattta ctacatcatt aattgatgtt     2400

actctggagt ttagaattct ggcattgaca tttccctctc tttcctttat ttcgatgaag     2460

ctataattgt gaaaattgta actacataga tgctgaaagg ctaatacaca catatgcaca     2520

tgtatttgat tgtcaaaggt atattcttaa atttgggtat tattgaaaat attttccatg     2580

ccttggtgct agcatataag tttggaagtt tgccaacatc acaattcatc ttgaaaagag     2640

cttttttccc tcctaccaca tacaccattc ttagggagca atgaggtaac aggtctgtgt     2700

tgtctagatc tttgcttttt atccccctat cagtccaggg catatactaa cctgcaaact     2760

gattctgaat caggaaggtg gtaatcaata agtattctgg ctgggaaaga ccgtgggccc     2820

aatgatcaaa gtcttcttgg tgctgttcat taattcttgt gccttttggc ttgttttcta     2880

gagtttctgg gctttggctg ctgatactgc ctttcttaga ctgtaatttt tatctgcatg     2940

cccagtttct gacctatcaa cttgggtttt attgtgcact ctaactgagc ttgtcttcat     3000

aattttctgt ttattgccct gggcttggat atgtctcaag acactcatgt gaatcatgcc     3060

accccaaatc ctggcttatc aagtcccaga ctataaatta tgaactccca ttagcttggt     3120

actaacatat acttgatgta ggtatttatg gacttgatga tccaagaata ttatattctt     3180

caaaatggtt aagctccatg gagttagatg actacactta atgctattaa gttgaacttt     3240

tgaatgtcaa ctaatttgca atcaattaaa gatacatatg cctaga                    3286


<210>  17
<211>  5496
<212>  DNA
<213>  Homo sapiens

<400>  17
tgctccgcgc gctagctggc tgtgtggctc gctggctcgc tagggacaag caggaatcgg       60

agcagcactg ccgcctctgg cgcgaaggct caggcgcctc ctcccgccac agtcactgtg      120

gctcggcgca cgctgccggc ggctgccctt tccgcctctg gggaagaaaa acccgcgggc      180

cgctttcgtg cttgaaccat ggcctcgggc cggaggggct gggacagctc ccacgaagac      240

gatctgcccg tgtacctggc caggccgggc accacggacc aggtcccgcg gcagaaatac      300

ggcggcatgt tctgcaacgt ggagggcgcc ttcgagagca agacgctgga tttcgatgcc      360

ctcagcgtgg ggcagcgggg cgcgaagact cctcggagcg gccagggcag cgaccgagga      420

tcggggagtc ggcccgggat cgagggggac accccgcgca ggggccaagg ccgggaagag      480

agcagggagc ccgcgcccgc ctcccccgcc cccgccgggg tagagatccg gagcgccacc      540

ggcaaagagg tgttgcagaa cctcggcccc aaggacaaga gtgaccgtct ccttatcaag      600

ggaggcagaa tcgtcaatga tgatcagtcc ttttatgctg atatttacat ggaagatggc      660

ttaataaaac aaattggaga caatctgatt gttcctggag gagtgaagac cattgaagcc      720

aatgggaaga tggtgatccc tggaggcatc gatgtccata ctcacttcca gatgccatat      780

aagggaatga ccacagtaga tgacttcttc caagggacaa aggcggcctt agcaggtggc      840

accaccatga tcattgacca tgtggtgcct gagcctgagt ccagcctgac tgaggcctat      900

gagaaatgga gagagtgggc tgatgggaag agttgctgtg actatgccct gcatgtggac      960

atcacccact ggaatgacag cgtcaagcag gaagtgcaga acctcatcaa ggacaaaggg     1020

gttaactcct tcatggttta tatggcttat aaggatttgt atcaagtatc taacacagag     1080

ctctatgaga tcttcacctg cctgggagag ctgggggcca ttgctcaagt tcatgctgag     1140

aatggggata tcattgccca ggagcaaacc cgcatgttgg aaatggggat aactggccca     1200

gaaggccatg tactgagcag gccagaagag ctggaagctg aggctgtgtt ccgtgccatc     1260

accattgcca gccaaaccaa ttgccctctc tacgtcacaa aggtcatgag caagagtgca     1320

gctgacctca tctcacaagc caggaaaaaa ggaaatgtag tctttggtga gcccatcact     1380

gccagcctcg gcatagatgg aacccattat tggagcaaga actgggccaa ggcggctgca     1440

tttgtgacat ccccacccct gagccctgac ccaactactc cggactacat caactccttg     1500

ctggccagcg gggatctgca gctatctggg agtgcccact gcaccttcag cactgcccag     1560

aaagcaattg ggaaggacaa cttcacagcc attcctgagg gcaccaatgg tgtggaggag     1620

cggatgtctg tcatctggga caaggctgtg gccacaggga aaatggacga aaaccagttc     1680

gtggctgtga caagcacaaa cgctgccaag atcttcaacc tgtatccccg caagggaaga     1740

atatctgtgg gttctgacag cgacctcgtc atctgggatc cagatgctgt gaagatcgtc     1800

tctgccaaga accaccagtc tgcggcagag tacaacatct ttgaagggat ggagctgcgc     1860

ggggctcctc tggttgtcat ctgccagggc aagatcatgc tggaagatgg caacctgcac     1920

gtgacccagg gggctggccg cttcataccc tgcagcccgt tctccgacta tgtctacaag     1980

cgcattaaag cacggaggaa gatggcagac ctgcatgccg tcccaagggg catgtacgat     2040

gggcctgtgt ttgacctgac caccaccccc aaaggtggca cccccgcagg ctctgctcgg     2100

ggctctccta ctcggccgaa cccacctgtg aggaatcttc atcagtcggg atttagcctg     2160

tcaggcaccc aagtggatga gggggttcgc tcagccagca agcgcatcgt ggcgccccca     2220

ggcggccgtt ctaatatcac atctctgagt taagcaagcc ttcctcaaag agaggggcag     2280

aagcaagaag agattgtttt gaagccaaaa tggtacaccg atatttaaga aggaaagcga     2340

atccaaacgg ttgtgatcta aagaatcaat aagcctcaag ccttatgttt ctccaatgtt     2400

acgctcgctt gcctagcttt acgaatattg ctttgttttc tgtttatgca tagccttgat     2460

ttgtttgact cccctccccc catttacatg catgcaatca gacaggccac taaggtaaaa     2520

gagtctgctc tatcatagtg ttgagagcgt gtgtagtgct gcatcttatg acaaggggac     2580

agacaagctg ggacgtcagg gaaatgaaca aaagggacgc aggttatttg gggtgagtgg     2640

gtggtgggag cctggagcaa ggtggagggt gcagaggggc tggggtaggg catgtaggag     2700

ggaggtgggt gggtcaggtg agtggaaggg gtgttgtata ttgtgttgat gacgtacgtt     2760

atttccatgg aagatagccg ctgtggcagc tgtcacatca ccacagctcc ctagggtctg     2820

ccgagaaggc aggcagtctt tgggttctgt tctttgtcac gtcccctaca agtaaatttt     2880

gtttctttga acgtttatta aaatgccaag acccaaccat ttcttccacc tgcttgattg     2940

tgccagtgtt tgctcaggcc tctttcttag tgttgctttc aaatccttct ctttcctggg     3000

ttgggaaggc caggcaggga cagagcaaat gacacttctc ttcctcttgc cctccctgcc     3060

tctttggtgc tcttaaaagc cagcagctga gaacatagca caggcccacg tggtgagggc     3120

acccacagct taaagacgct tccttctaaa cacggcgagg tcacctctca ctcttctgtc     3180

tttgcaaacc gagaagagtg gcatgcttct ggcatcccaa gtcaggattt tagctcagat     3240

gaggcagaat gaagggcctc tcttacaggc agtttgtgtt tgattctctc gatcctggca     3300

catccatgat aaataggagt ttttgaaagt tggttttatt aggtgttccc taatttttac     3360

cgtaataggt catctcagct tatatgaaag tcaagtgggg aactgggaaa gccaaagtca     3420

gtcttgagca gagggagcac attttgtgga cctggttcca cctttccatt ccaaaccacc     3480

tgtttcccct tccattagca gaaactctgg gggaactttg tgtctcagtc ctagaatctc     3540

cccaagtgag tggaagtgac atgatgcagt cttcctcatg gggcacctga aagaaattag     3600

tgtgggtgct tcgatctacc ttgtctgtca gagttgaata tctctttccc tatcatgctg     3660

cttctgaaaa ttcagttttg gagcaagtcc tgtgagcaag ataagaatct atagaaccaa     3720

gatgctcatt ttcagaagaa atatgttcaa cctgggatca gacttccatg ctctggggaa     3780

tccaagtggt agcacctgta accctgtgta ctaagtgctt tgaagagaag agcaggcctc     3840

agacaccttt taattgctta ggagaaacca ttgtctctga ctgcaggttt gaataagttg     3900

aagaccagag aaaagtacac actgggctac aaaggaattt ggagatagcc aaggaacagg     3960

atttccccta gcaagctacc ttctgttcaa atcatgaaaa aagactattt ccccttagaa     4020

tagggaagct tgctatttta aagctcttgt agtgcttttc ttttaaggga gatgtagtaa     4080

aagggaaaat gtagctctta gtttacactt caaagatgtg ggggtctttc agagaactaa     4140

gaataacagt tttatgtgca gagagagttt gccagatctg aagcatatac ctcattgact     4200

aggctgttac tttgggatag gttgcagtac cagccacagc cagcagatag aggaaaagac     4260

acacataaac tcgcttctga gcgtccactt ctgcactctc tgctctgctg ttactcagcc     4320

cctgagtctg actcatctct gcacaacctc tctgtgccat gaagataagt cttccatggc     4380

caaatcggtc atccgcactg cccttgggac ttccgaagtg aaccattcca ccagaacctt     4440

tgattctgca caagatttcc ttgctctggg aacaaccccc aaatgccctt gggaggaaca     4500

acatgagctc aggaagcctc tctttcttca cttaccatta ctaactctcc aagcatagaa     4560

atccctggga attgcgagaa taactcccac tattttaaaa tttatattca gatttgtttc     4620

gtttcataag acacatcaaa caggcctata caaaaggttt aggaaaagaa aacaatggtg     4680

agtcccggcc ctcttcgaat tcactggcac ctcatgcaag tgtaggaagg cacgctggat     4740

cgtctatctg attccaaagc tgtcctttgc catctcatcc cttggcctgc cccccaaccc     4800

tgaggatgcc cctgccatcc ccccaacctc ctcatattgc ctctgaaccc agatggcaat     4860

ccatcccggt tctctctgag ggccacgggc ttgggtagtg gaaagggtgt ttgggaaatt     4920

gttaaatcag ttacccgtag tagagctatt tcttgtactt ctaagttttc tagaagtgga     4980

aggattgtag tcatcctgaa aatgggttta cttcaaaatc cctcagcctt gttcttcacg     5040

actgtctata ctgagagtgt catgtttcca caaagggctg acacctgagc ctggattttc     5100

actcatccct gagaagccct ttccagtagg gtgggcaatt cccaacttcc ttgccacaag     5160

cttcccaggc tttctcccct ggaaaactcc agcttgagtc ccagatacac tcatgggctg     5220

ccctgggcag ccagcattca ttgtaagttc cctctttgaa aactggtgtg tgggtgttca     5280

gttctgtgtc tggtgggtat ggacagacag taatctcctg tgatctgtgc tagctgtgag     5340

gcagctctgg aacgtgaaga gctgtttggt ttgaaccgtg aacaaaactg tgttttgagt     5400

ttagctgaca ttaaagaaaa aagttcatca cgtgactgtt aatgtaaacc tggttattaa     5460

aataactatg aaattaccaa aaaaaaaaaa aaaaaa                               5496


<210>  18
<211>  6978
<212>  DNA
<213>  Homo sapiens

<400>  18
gaagttgctc ccgggcaggc aagcctgaga gaggccaaat acacttaaaa acaagcagcg       60

gcgagaaaag cacctcccgc gccctgcacc tcggcaggtc tcgctctcgg caccctcccg      120

gcgcccgcgt tctcctggcc ctgcccggca tcccgatggc cgccgctggg ccccggcgct      180

ccgtgcgcgg agccgtctgc ctgcatctgc tgctgaccct cgtgatcttc agtcgtgctg      240

gtgaagcctg caaaaaggtg atacttaatg taccttctaa actagaggca gacaaaataa      300

ttggcagagt taatttggaa gagtgcttca ggtctgcaga cctcatccgg tcaagtgatc      360

ctgatttcag agttctaaat gatgggtcag tgtacacagc cagggctgtt gcgctgtctg      420

ataagaaaag atcatttacc atatggcttt ctgacaaaag gaaacagaca cagaaagagg      480

ttactgtgct gctagaacat cagaagaagg tatcgaagac aagacacact agagaaactg      540

ttctcaggcg tgccaagagg agatgggcac ctattccttg ctctatgcaa gagaattcct      600

tgggcccttt cccattgttt cttcaacaag ttgaatctga tgcagcacag aactatactg      660

tcttctactc aataagtgga cgtggagttg ataaagaacc tttaaatttg ttttatatag      720

aaagagacac tggaaatcta ttttgcactc ggcctgtgga tcgtgaagaa tatgatgttt      780

ttgatttgat tgcttatgcg tcaactgcag atggatattc agcagatctg cccctcccac      840

tacccatcag ggtagaggat gaaaatgaca accaccctgt tttcacagaa gcaatttata      900

attttgaagt tttggaaagt agtagacctg gtactacagt gggggtggtt tgtgccacag      960

acagagatga accggacaca atgcatacgc gcctgaaata cagcattttg cagcagacac     1020

caaggtcacc tgggctcttt tctgtgcatc ccagcacagg cgtaatcacc acagtctctc     1080

attatttgga cagagaggtt gtagacaagt actcattgat aatgaaagta caagacatgg     1140

atggccagtt ttttggattg ataggcacat caacttgtat cataacagta acagattcaa     1200

atgataatgc acccactttc agacaaaatg cttatgaagc atttgtagag gaaaatgcat     1260

tcaatgtgga aatcttacga atacctatag aagataagga tttaattaac actgccaatt     1320

ggagagtcaa ttttaccatt ttaaagggaa atgaaaatgg acatttcaaa atcagcacag     1380

acaaagaaac taatgaaggt gttctttctg ttgtaaagcc actgaattat gaagaaaacc     1440

gtcaagtgaa cctggaaatt ggagtaaaca atgaagcgcc atttgctaga gatattccca     1500

gagtgacagc cttgaacaga gccttggtta cagttcatgt gagggatctg gatgaggggc     1560

ctgaatgcac tcctgcagcc caatatgtgc ggattaaaga aaacttagca gtggggtcaa     1620

agatcaacgg ctataaggca tatgaccccg aaaatagaaa tggcaatggt ttaaggtaca     1680

aaaaattgca tgatcctaaa ggttggatca ccattgatga aatttcaggg tcaatcataa     1740

cttccaaaat cctggatagg gaggttgaaa ctcccaaaaa tgagttgtat aatattacag     1800

tcctggcaat agacaaagat gatagatcat gtactggaac acttgctgtg aacattgaag     1860

atgtaaatga taatccacca gaaatacttc aagaatatgt agtcatttgc aaaccaaaaa     1920

tggggtatac cgacatttta gctgttgatc ctgatgaacc tgtccatgga gctccatttt     1980

atttcagttt gcccaatact tctccagaaa tcagtagact gtggagcctc accaaagtta     2040

atgatacagc tgcccgtctt tcatatcaga aaaatgctgg atttcaagaa tataccattc     2100

ctattactgt aaaagacagg gccggccaag ctgcaacaaa attattgaga gttaatctgt     2160

gtgaatgtac tcatccaact cagtgtcgtg cgacttcaag gagtacagga gtaatacttg     2220

gaaaatgggc aatccttgca atattactgg gtatagcact gctcttttct gtattgctaa     2280

ctttagtatg tggagttttt ggtgcaacta aagggaaacg ttttcctgaa gatttagcac     2340

agcaaaactt aattatatca aacacagaag cacctggaga cgatagagtg tgctctgcca     2400

atggatttat gacccaaact accaacaact ctagccaagg tttttgtggt actatgggat     2460

caggaatgaa aaatggaggg caggaaacca ttgaaatgat gaaaggagga aaccagacct     2520

tggaatcctg ccggggggct gggcatcatc ataccctgga ctcctgcagg ggaggacaca     2580

cggaggtgga caactgcaga tacacttact cggagtggca cagttttact caaccccgtc     2640

tcggtgaaga atccattaga ggacacactg gttaaaaatt aaacataaaa gaaattgcat     2700

cgatgtaatc agaatgaaga ccgcatgcca tcccaagatt atgtcctcac ttataactat     2760

gagggaagag gatctccagc tggttctgtg ggctgctgca gtgaaaagca ggaagaagat     2820

ggccttgact ttttaaataa tttggaaccc aaatttatta cattagcaga agcatgcaca     2880

aagagataat gtcacagtgc tacaattagg tctttgtcag acattctgga ggtttccaaa     2940

aataatattg taaagttcaa tttcaacatg tatgtatatg atgatttttt tctcaatttt     3000

gaattatgct actcaccaat ttatattttt aaagcaagtt gttgcttatc ttttccaaaa     3060

agtgaaaaat gttaaaacag acaactggta aatctcaaac tccagcactg gaattaaggt     3120

ctctaaagca tctgctcttt ttttttttta cggatatttt agtaataaat atgctggata     3180

aatattagtc caacaatagc taagttatgc taatatcaca ttattatgta ttcactttaa     3240

gtgatagttt aaaaaataaa caagaaatat tgagtatcac tatgtgaaga aagttttgga     3300

aaagaaacaa tgaagactga attaaattaa aaatgttgca gctcataaag aattgggact     3360

cacccctact gcactaccaa attcatttga ctttggaggc aaaatgtgtt gaagtgccct     3420

atgaagtagc aattttctat aggaatatag ttggaaataa atgtgtgtgt gtatattatt     3480

attaatcaat gcaatattta aaatgaaatg agaacaaaga ggaaaatggt aaaaacttga     3540

aatgaggctg gggtatagtt tgtcctacaa tagaaaaaag agagagcttc ctaggcctgg     3600

gctcttaaat gctgcattat aactgagtct atgaggaaat agttcctgtc caatttgtgt     3660

aatttgttta aaattgtaaa taaattaaac ttttctggtt tctgtgggaa ggaaataggg     3720

aatccaatgg aacagtagct ttgctttgca gtctgtttca agatttctgc atccacaagt     3780

tagtagcaaa ctggggaata ctcgctgcag ctggggttcc ctgctttttg gtagcaaggg     3840

tccagagatg aggtgttttt ttcggggagc taataacaaa aacattttaa aacttacctt     3900

tactgaagtt aaatcctcta ttgctgtttc tattctctct tatagtgacc aacatctttt     3960

taatttagat ccaaataacc atgtcctcct agagtttaga ggctagaggg agctgagggg     4020

aggatcttac tgaaagcacc ctggggagat tgattgtcct taaacctaag ccccacaaac     4080

ttgacacctg atcaggtctg ggagctacaa aatttcattt ttctcctcac tgcccttctt     4140

ctgagtggca ttggcctgaa tcaaggaaag ccaggccttg tgggccccct tctttcggct     4200

ttctgctaaa gcaacacctc cagcagagat tcccttaagt gactccaggt tttccaccat     4260

ccttcagcgt gaattaattt ttaatcagtt tgctttctcc agagaaattt taaaataata     4320

gaagaaatag aaattttgaa tgtataaaag aaaaagatca agttgtcatt ttagaacaga     4380

gggaactttg ggagaaagca gcccaagtag gttatttgta cagtcagagg gcaacaggaa     4440

gatgcaggcc ttcaagggca aggagaggcc acaaggaata tgggtgggag taaaagcaac     4500

atcgtctgct tcatactttt tcctaggctt ggcactgcct tttcctttct caggccaatg     4560

gcaactgcca tttgagtccg gtgagggatc agccaacctc ttctctatgg ctcaccttat     4620

ttggagtgag aaatcaagga gacagagctg actgcatgat gagtctgaag gcatttgcag     4680

gatgagcctg aactggttgt gcagaacaaa caaggcattc atgggaattg ttgtattcct     4740

tctgcagccc tccttctggg cactaagaag gtctatgaat taaatgccta tctaaaattc     4800

tgatttattc ctacattttc tgttttctaa tttgacccta aaatctatgt gttttagact     4860

tagacttttt attgcccccc cccccccctt ttttttttga gacggagtct cgctctgacg     4920

cacaggctgg agtgcagtgg ctccgatctc tgctcactga aagctccgcc tcccgggttc     4980

acgccattct cctgcctcag cctcctgagt agctgggact acaggcgccc accaccacgc     5040

ccggctaatt ttttgtattt ttaatagaga cggggtttca ctgtgttagc caggatggtc     5100

tcgatctcct gacctcgtga tccgcctgcc tcggcctccc aaagtgctgg gattacaggc     5160

atgacccacc gctcccggcc ttgttttccg tttaaagtcg tcttctttta atgtaatcat     5220

tttgaacatg tgtgaaagtt gatcatacga attggatcaa tcttgaaata ctcaaccaaa     5280

agacagtcga gaagccaggg ggagaaagaa ctcagggcac aaaatattgg tctgagaatg     5340

gaattctctg taagcctagt tgctgaaatt tcctgctgta tccagaagcc agttttatct     5400

aacggctact gaaacaccca ctgtgttttg ctcactccct cactcaccga tcaaaacctg     5460

ctacctcccc aagactttac tagtgccgat aaactttctc aaagagcaac cagtatcact     5520

tccctgttta taaaacctct aaccatctct ttgttctttg aacatgctga aaaccacctg     5580

gtctgcatgt atgcccgaat ttgtaattct tttctctcaa atgaaaattt aattttaggg     5640

attcatttct atattttcac atatgtagta ttattatttc cttatatgtg taaggtgaaa     5700

tttatggtat ttgagtgtgc aagaaaatat atttttaaag ctttcatttt tcccccagtg     5760

aatgatttag aattttttat gtaaatatac agaatgtttt ttcttacttt tataaggaag     5820

cagctgtcta aaatgcagtg gggtttgttt tgcaatgttt taaacagagt tttagtattg     5880

ctattaaaag aagttacttt gcttttaaag aaacttggct gcttaaaata agcaaaaatt     5940

ggatgcgtaa agtaatattt acagatgtgg ggagatgtaa taaaacaata ttaacttggt     6000

ttcttgtttt tgctgtattt agagattaaa taattctaag atgatcactt tgcaaaatta     6060

tgcttatggc tggcatggaa atagaaataa ttatgtcttt gttgtattaa tggggaatat     6120

tttggacaat gtttcattat caaattgtcg acatcattaa tatatattgt aatgttggga     6180

agagatcact attttgaagc acagctttac agatgagtat ctatgataca tatgtataat     6240

aaattttgat tgggtattaa aagtattaga aggtggttat aattgcagag tattccatga     6300

atagtacact gacacagggg ttttactttg aggaccagtg tagtcaaggg aaaacatgag     6360

ttaaaaagaa aagcaggcga tattgcagtc ttgattctgc cacttacagg atagataacg     6420

cctgaacttt aatgacaaga tgatccaacc ataaaggtgc tctgtgcttc acagtgaatc     6480

ttttccccat gcaggagtgt gctcccctac aaacgttaag actgatcatt tcaaaaatct     6540

attagctata tcaaaagcct tacattttaa tataggttga accaaaattt caattccagt     6600

aacttctatt gtaaccatta tttttgtgta tgtcttcaag aatgttcatt ggatttttgt     6660

ttgtaatagt aaaataccgg atacatttca cgtgtccttc agtattgatt tggttgaata     6720

ttgggtcata atggttgaga agcatggaca ctagagccag aatgcttgga tatgaatcct     6780

ggatctgtca cttacttctg tgtgaccttt gaaaggctac ttatttcctc tcttagcttt     6840

ctcattaaaa tcaatgaaca atgccagcct catggggttg ttgaatgatt aaatgagtta     6900

ctatacctaa agtacataga acactgcctg cacatagtaa aagaattata agtgtgaggt     6960

agttggtaaa attatgta                                                   6978


<210>  19
<211>  8082
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgacggcct cggccgcggg cgtttacact ggctctgcct ccggcatctc ttcgccggtg       60

cgtcctcgcc gcgcccgtag gtcccggcag ccgggccccg cctccttcgg agtccgagcg      120

atgggcgggg aaagggacag gcaggtatag ctctgtcggc gccgcggtgt ccacctcagt      180

caggccacgg tggaagacgc gtgccgcggc gcctggttgc ctgcagcggc ccggacccga      240

gaggaagctg aaccatctat ctccagaaat gtcttcagaa agtaaagagc aacataacgt      300

ttcacccaga gactcagctg aaggaaatga cagttatcca tctgggatcc atctggaact      360

tcaaagggaa tcaagtactg acttcaagca atttgagacc aatgatcaat gcagacctta      420

tcataggatc cttattgagc gtcaagagaa atcagataca aacttcaagg agtttgttat      480

taaaaagctg cagaagaatt gccagtgcag tccagccaaa gccaaaaata tgattttagg      540

tttccttcct gttttgcagt ggctcccaaa atacgaccta aagaaaaaca ttttagggga      600

tgtgatgtca ggcttgattg tgggcatatt attggtgccc cagtccattg cttattccct      660

gctggctggc caagaacctg tctatggtct gtacacatct ttttttgcca gcatcattta      720

ttttctcttg ggtacctccc gtcacatctc tgtgggcatt tttggagtac tgtgccttat      780

gattggtgag acagttgacc gagaactaca gaaagctggc tatgacaatg cccatagtgc      840

tccttcctta ggaatggttt caaatgggag cacattatta aatcatacat cagacaggat      900

atgtgacaaa agttgctatg caattatggt tggcagcact gtaaccttta tagctggagt      960

ttatcaggta gcgatgggct tctttcaagt gggttttgtt tctgtctacc tctcagatgc     1020

cttgctgagt ggatttgtca ctggtgcctc cttcactatt cttacatctc aggccaagta     1080

tcttcttggg ctcaaccttc ctcggactaa tggtgtgggc tcactcatca ctacctggat     1140

acatgtcttc agaaacatcc ataagaccaa tctctgtgat cttatcacca gccttttgtg     1200

ccttttggtt cttttgccaa ccaaagaact caatgaacac ttcaaatcca agcttaaggc     1260

accgattcct attgaacttg ttgttgttgt agcagccaca ttagcctctc attttggaaa     1320

actacatgaa aattataatt ctagtattgc tggacatatt cccactgggt ttatgccacc     1380

caaagtacca gaatggaacc taattcctag tgtggctgta gatgcaatag ctatttccat     1440

cattggtttt gctatcactg tatcactttc tgagatgttt gccaagaaac atggttacac     1500

agtcaaagca aaccaggaaa tgtatgccat tggcttttgt aatatcatcc cttccttctt     1560

ccactgtttt actactagtg cagctcttgc aaagacattg gttaaagaat caacaggctg     1620

ccatactcag ctttctggtg tggtaacagc cctggttctt ttgttggtcc tcctagtaat     1680

agctcctttg ttctattccc ttcaaaaaag tgtccttggt gtgatcacaa ttgtaaatct     1740

acggggagcc cttcgtaaat ttagggatct tcccaaaatg tggagtatta gtagaatgga     1800

tacagttatc tggtttgtta ctatgctgtc ctctgcactg ctaagtactg aaataggcct     1860

acttgttggg gtttgttttt ctatattttg tgtcatcctc cgcactcaga agccaaagag     1920

ttcactgctt ggcttggtgg aagagtctga ggtctttgaa tctgtgtctg cttacaagaa     1980

ccttcagatt aagccaggca tcaagatttt ccgctttgta gcccctctct actacataaa     2040

caaagaatgc tttaaatctg ctttatacaa acaaactgtc aacccaatct taataaaggt     2100

ggcttggaag aaggcagcaa agagaaagat caaagaaaaa gtagtgactc ttggtggaat     2160

ccaggatgaa atgtcagtgc aactttccca tgatcccttg gagctgcata ctatagtgat     2220

tgactgcagt gcaattcaat ttttagatac agcagggatc cacacactga aagaagttcg     2280

cagagattat gaagccattg gaatccaggt tctgctggct cagtgcaatc ccactgtgag     2340

ggattcccta accaacggag aatattgcaa aaaggaagaa gaaaaccttc tcttctatag     2400

tgtgtatgaa gcgatggctt ttgcagaagt atctaaaaat cagaaaggag tatgtgttcc     2460

caatggtctg agtcttagta gtgattaatt gagaaggtag atagaagaat gtctagccaa     2520

taggttaaaa tttcaagtgt ccaacatttc ccagttccac agtgggaaat tttgcacact     2580

tgaaatttta accaagtggc tagatattat tcctcctttg aagctaatgg catttgtata     2640

tacacactgc agcagagctt gtagctggac agagtcaaaa agaagaaaat acggtttcag     2700

gctttcttgc agatatgaag tattcttgga atgcaataag tatgtattga actgtactgt     2760

aaagtagctc caaaacttaa ttactctcct gttttagggg ttatacattt ggactgtgca     2820

ttctccaaga gatgaagcgg tgaagttggg atttacattg gaagtgctgt agacttcttt     2880

atgtggctca gtggagagag ggaaagaatg ttgcacctgc tctagtacca taggtcaaga     2940

ggcttctgga tcacaaagtc ataactagac aggtttgttc ttgtagtttt ctatccccag     3000

tctttgctcc ccagatggca gtagttttta gtaggaaagt gccattcctg tccttaaggc     3060

acagtctcat cagaagtcta atacctgggc aggtttataa catcctgaga gccagcctga     3120

cattagacag aatacccttt gtaatacatt ggaaattttt actcatgcct ttttgtttag     3180

gataaatagg taagcacaaa gagctcttca aaatcagaaa aaacaatagg agtccttcct     3240

tgtcttttct gtgatctctg tccttgtttc tgagactttc tctaccatta agctctattt     3300

tagctttcag ttattctagt ttgtttccca tggaatctgt cctaaactgg tgtttttgtc     3360

agtgacagtc ttgccagtca gcaatttcta acagcatttt aaatgagttt gatgtacagt     3420

aaatattgat gacaatgaca gcttttaact cttcaagtca cctaaagcta ttatgcagga     3480

ggatttagaa gtcacattca taaaacccaa gtgctatggg tgtattattc atgatagctg     3540

gcccacaggt catgaattga ggaggaattt gctttcaaaa agcaagaatg tccaacactg     3600

aaagtttata gttttatatt tggaccttga aaggtaagaa aaaaccaggt tctccaaagt     3660

taggaatagg gaactaattt atgaaacagc catcttaaaa aaaaaaaaag taaactgcaa     3720

aagtacaaaa tcatttttca atctgttccc agtttctaaa caattttaaa tatttatgag     3780

aagcaaaccc tatgtgtagg gcatctgttg gagtgggatg cttttagaca tatattaagt     3840

atgtacatgt ttaatatgta tatttaaaat gcatatatat tttattatat ctatattatc     3900

ctatatagat atatgtaact tagctttatt gttagctcca taagctgcca gtgttgcttt     3960

tctgttggta gagctctccc atttggtgac atggaaaata cctttccatt atcacaacaa     4020

agcagttgct cagtagaaag tctagatttc tgtcttatag gtgatttctg tcttataggt     4080

gattataatc aagtgtaggc ttcctgaatt ttgacatcct tttagaactt gggtctggaa     4140

ttccagaaat gttaattgct gcttgtattt gttcttgttt gttttttagc cagtatttgc     4200

cctttctatc cagccttatg aataatagca gtaaaatcac agtatcttgg tcagtcttta     4260

tttttttcct tttttctttt ttaagagaca gtcatccagg ccagagtgca gtttgatgat     4320

agcttactga agcttcccac tcctgggctc aagttatcct tccattttgg cctcctgagt     4380

agctagacca taggtatgca tcaccacacc ctgctaattt tttaaatttt tttctagaga     4440

gagggtctca ctgtgttgcc caggctggtc tcaaactcca ggctcaagca atccttcagc     4500

ctcagcctcc cagagtgttg ggattacagg cgtgagccac tgcacttggc caagttattt     4560

atttttaatc tctcttgccc ttctcccaag gcaggcttaa gttgagacta ttataggtgt     4620

ctaataacct gtgacagagt aatgagtaca tgcttaagat gttataatta gccaacacca     4680

acacagcaaa aaatataatt ccagccaaag attctggaaa atccctcaga aggagggata     4740

acaggatttg acctttacca gcgatttctg tccatatgtg gatgtaaaca gttctggaac     4800

gttatgcatg cagttagcga atccttgaat tatgttctgg tttgtacttg tcccatccat     4860

ccaaacaaga gattctgctt ttggtagcca tctgtagaaa catttaagat gtcactagaa     4920

tttacatttc atcctctcta cttgggttga ggttgcctat acttgcatat tgttaaaatg     4980

ttttggttgc tgatattcag aggaatgaaa cctggaacca aagcctaatt tgccgataaa     5040

aaaactgttt tcggccaggt gcagtggctc atgcctgtaa tcccagcacg ttgggaggcc     5100

gaggcgggtg gatcacctga agtcaggagt tcgagaccat cctggctaac actgtgaaac     5160

cccgtctcta ctaaaaatac aaaaaattag cggggcatgg tggcacgcgc ctgtagtccc     5220

agctactcag gaggctgagg caggagaatt acttgaaccc gggaggcgga ggttgcagta     5280

agcagagatt gtgccactgg actccagcct gggtgacaga gcgagactcc gtctcaaaca     5340

aacaaacaaa aaactgtttt catttgctct cttgaccaaa ggataggact ttagttcttt     5400

aagcattatt ttaaacacta tattgataca aaaatatctt gcttactcta aactttagag     5460

tctaaatgaa gctttttctc agtacaagat tctgagtatc ataaaatggt tatttaattg     5520

aaacgtagtg tggtatactc ttgatggtta gaactcttac agccttattt atttttaagt     5580

ttgttacagc caaagggttg gagtgtgcca gtgcacaggt agactaagga aaacattata     5640

gaggagtgaa gagaacagac cattgaaaag actattatct gaccagcgga ggcagaaaag     5700

agaggaaccc agttgaatag gatccaatcc ctggttagcc tctacacaat aatagggaga     5760

caaggattag gagccatacc tcccagagca aggtatcttt ctagagcaaa tttctctttc     5820

tagaagggga gggtcacagg gtcacagatt caccaaagct gaaagggctg aggagctcat     5880

ggtagcctgg gctgacctac tctggagcac ggtgtcttcc ttctaaactg agtgactgta     5940

gtactatctg tgcctctgat ggtaataaaa ctgacaagat gtctaatttt tttttaagta     6000

ggaccaaagg aaaacaagat ttagatagtc tgactttgct tttgaacaac agacattgca     6060

agtcaaaatt gttgtcaaat ttacatatgg taaatgatga actttaaaaa tgtgtccagg     6120

tgttagatga gttcattaga ctcttttaat gctaatggct agtacgttta aacaaaacag     6180

cagttctctg ctgcaatatt cccattgacc acttaaatga ccataagtgg tcatttaaga     6240

acatgttagg gttagccctg atctgaatat aaaagtgaga aaagggctac agtgcatttc     6300

ttggtaactt aaactgagtc ttgaagttat aatgatccat tcgagttctg tgatccttat     6360

tgttcttaat tgtgtttctc tacgtattgt tacagatgag ccatacgttt ctttgtatca     6420

atgtagacat gacttcagat acctctgagg acctacccag cagtctagga ccctgggcca     6480

agtgctggga ctatggtact aaatccagta gatgggctgt gtagcaactc tcccagggaa     6540

cacactaggg tacttaggga ggtgctttgt ggagcatgtt gaagctttga gatctgagca     6600

ggaggcagtg atgtccctgg tctattcagg gaaagatttc agtgtgaaat ggtaaacatc     6660

caattgacag gatttagatt ttgcttagtt tttctgcttt ttaatgtttc tatcccccat     6720

ctcagtgttt tctttatcca tcccagtgat gccttatttg aaactgggct taaactgcaa     6780

aaagaatgaa gttggattta ggaagctgtt agatcattga gtggtgttga gagtgaagtt     6840

tcactagcag ggaagtttcc ttgagcctaa aataaaaaga aaaaattaaa aagaatcagt     6900

ttttttaatt aaaaaaatag aaagctgtta ggctcctaat tcgtggggtt tttttttgta     6960

aaaacagttt agataatcct gaatgcaatc attaacttgg ttgctaatta caagaatgaa     7020

aattataatg gaaaaggaca aaataatata ccagctggtt tgttattata gtccgtgtat     7080

taaaatacta ttgaaatacg ttaaaggtaa atttttaagg tttaaaaaaa atttagtaac     7140

ttacagggat ggagaattta gatgtcagag gtggggagat ttatttttat aaggtaattt     7200

ttatcctgat aaggacttaa aaaaaagttt tgcaactgaa attttaaagt aaacatgtta     7260

agtacagtta aaaagtaagc attgtagtaa atagtggatt ctctggtgtg tattttttat     7320

ctcagtgttg aaaattggaa aagaatggac tgaagtctaa aaactggaat aatgaaggac     7380

actaaatgcc tttattgtag atactatgtt tgtaagtcta tagctaagca acttaagcca     7440

aaaaggtctt tcaactgaag ctttaatcaa cttattttgg agatgttctc ttcccttatc     7500

tcatgcgtca tccctaaaat aataagatac atgggatcaa atagcccttg ccttttcaac     7560

acaaatcagt tggaaaatta tggtttgagt cctgttgctg ccatggcttc tgtttctcag     7620

aaatgagtgt gtatgaacat accaatctat gtaataggct accttttttt gtcttctttg     7680

gaactttgta cacaaaccaa gacaatatca gggtgacagg tgaatgaact taaattctca     7740

gtcttgtcta ttcaccaaaa aagtatactg cctgtttttt ctttaattat tcaaggttga     7800

tgacttttag gaacatgttt tatactgtat tttttaatta aagcaagtgc cttgatgtaa     7860

ttccatgtaa atcattgctt aaccctctta tgggatgagg atgagttatt aatgtattgc     7920

agcctactgg aaaggagggg gagttggtta atagcagata cttttcttct agaagcttat     7980

gttttatgct gtttattatg taagatcctg tatgtgtgtt gagatttaga ggtttcattt     8040

gttttgtctg ctaataaatt gttactctaa taataaaaaa aa                        8082


<210>  20
<211>  2545
<212>  DNA
<213>  Homo sapiens

<400>  20
actcattcac ataaaacgct gcgcggccgg cggaatcccc ggcttctagg gcggcgagcg       60

gccgggctgg ctatcgagcg agcggggcgg gaacgcggag ttgcgccgcc gctcgggcgc      120

cgggctccgt cgcggccgca gccccgcggg tcgccctccc gtgcctcgcc cgcggacacc      180

ctggccgtgg acaccctggc cgtgggcacc cgcggggcgc gcggcgcggg gccgctggcc      240

ggcggcggcg gcggcatgaa ggtcacgtcg ctcgacgggc gccagctgcg caagatgctc      300

cgcaaggagg cggcggcgcg ctgcgtggtg ctcgactgcc ggccctatct ggccttcgct      360

gcctcgaacg tgcgcggctc gctcaacgtc aacctcaact cggtggtgct gcggcgggcc      420

cggggcggcg cggtgtcggc gcgctacgtg ctgcccgacg aggcggcgcg cgcgcggctc      480

ctgcaggagg gcggcggcgg cgtcgcggcc gtggtggtgc tggaccaggg cagccgccac      540

tggcagaagc tgcgagagga gagcgccgcg cgtgtcgtcc tcacctcgct actcgcttgc      600

ctacccgccg gcccgcgggt ctacttcctc aaagggggat atgagacttt ctactcggaa      660

tatcctgagt gttgcgtgga tgtaaaaccc atttcacaag agaagattga gagtgagaga      720

gccctcatca gccagtgtgg aaaaccagtg gtaaatgtca gctacaggcc agcttatgac      780

cagggtggcc cagttgaaat ccttcccttc ctctaccttg gaagtgccta ccatgcatcc      840

aagtgcgagt tcctcgccaa cctgcacatc acagccctgc tgaatgtctc ccgacggacc      900

tccgaggcct gcgcgaccca cctacactac aaatggatcc ctgtggaaga cagccacacg      960

gctgacatta gctcccactt tcaagaagca atagacttca ttgactgtgt cagggaaaag     1020

ggaggcaagg tcctggtcca ctgtgaggct gggatctccc gttcacccac catctgcatg     1080

gcttacctta tgaagaccaa gcagttccgc ctgaaggagg ccttcgatta catcaagcag     1140

aggaggagca tggtctcgcc caactttggc ttcatgggcc agctcctgca gtacgaatct     1200

gagatcctgc cctccacgcc caacccccag cctccctcct gccaagggga ggcagcaggc     1260

tcttcactga taggccattt gcagacactg agccctgaca tgcagggtgc ctactgcaca     1320

ttccctgcct cggtgctggc accggtgcct acccactcaa cagtctcaga gctcagcaga     1380

agccctgtgg caacggccac atcctgctaa aactgggatg gaggaatcgg cccagcccca     1440

agagcaactg tgatttttgt ttttaagact catggacatt tcatacctgt gcaatactga     1500

agacctcatt ctgtcatgct gccccagtga gatagtgagt ggtcaccagg cttgcaaatg     1560

aacttcagac ggacctcagg gtaggttctc gggactgaag gaaggccaag ccattacggg     1620

agcacagcat gtgctgacta ctgtacttcc agacccctgc cctcttggga ctgcccagtc     1680

cttgcacctc agagttcgcc ttttcatttc aagcataagg caataaatac ctgcagcaac     1740

gtgggagaaa gaagttgctg gaccaggaga aaaggcagtt atgaagccaa ttcattttga     1800

aggaagcaca atttccacct tattttttga actttggcag tttcaatgtc tgtctctgtt     1860

gcttcggggc ataagctgat caccgtctag ttgggaaagt aaccctacag ggtttgtagg     1920

gacatgatca gcatcctgat ttgaaccctg aaatgttgtg tagacaccct cttgggtcca     1980

atgaggtagt tggttgaagt agcaagatgt tggcttttct ggattttttt tgccatgggt     2040

tcttcactga ccttggactt tggcatgatt cttagtcata cttgaacttg tctcattcca     2100

cctcttctca gagcaactct tcctttggga aaagagttct tcagatcata gaccaaaaaa     2160

gtcatacctt cgaggtggta gcagtagatt ccaggaggag aagggtactt gctaggtatc     2220

ctgggtcagt ggcggtgcaa actggtttcc tcagctgcct gtccttctgt gtgcttatgt     2280

ctcttgtgac aattgttttc ctccctgccc ctggaggttg tcttcaagct gtggacttct     2340

gggatttgca gattttgcaa cgtggtacta cttttttttt ctttttgtct gttagttatt     2400

tctccagggg aaaaggcaat aattttctaa gacccgtgtg aatgtgaaga aaagcagtat     2460

gttactggtt gttgttgttg ttcttgtttt ttatagtgta aaataaaaat agtaaaagga     2520

gaaaagcaaa aaaaaaaaaa aaaaa                                           2545


<210>  21
<211>  4457
<212>  DNA
<213>  Homo sapiens

<400>  21
gtcgcgggag gggcttccgc cgcgaggggg cggggccggc cctcagagtc ctctgacggc       60

cccagtcagg gaatttcaat ttgaaaccta gcggagggag gaggcaggcg cggctgccgg      120

cggctgggac tgaagaggga cgggtcccgc ggcgagcgag ctcctgagca taagctgtgg      180

ccatgactac tgaagtaggc tctgtgtctg aagtgaagaa ggactctagc cagttaggaa      240

cagatgcaac caaggaaaaa cctaaagaag tagcagaaaa tcagcagaat cagtcttccg      300

atccagagga ggaaaaaggt tcccagccac ctcctgcagc tgaaagccaa agtagtctac      360

gccgccagaa gagagagaag gaaacatcgg agagcagggg tatttctcgg ttcataccgc      420

catggcttaa gaagcaaaag tcatatacct tagtagtggc caaagatgga ggagataaaa      480

aagagcctac ccaagctgtt gttgaagaac aggtcttaga taaagaggaa ccccttccag      540

aagaacagag acaggctaag ggtgatgctg aagaaatggc tcagaagaaa caagagatta      600

aagttgaagt caaggaagaa aaaccctcag tgagcaagga agaaaaaccc tcagtgagca      660

aagtggagat gcagcctact gaattagtaa gtaaggagag agaagagaag gtaaaagaaa      720

cacaggaaga caaattagaa ggaggagcag caaaaaggga gaccaaggaa gtgcagacca      780

atgagctgaa agcagagaag gcatctcaaa aagtcaccaa gaagaccaaa actgtccagt      840

gtaaagtgac cctcttagat ggcaccgaat acagctgtga cctggagaaa catgccaagg      900

gacaagtgtt atttgacaaa gtgtgtgaac acctcaatct cttggagaaa gactactttg      960

gacttttgtt tcaggaaagc cctgagcaga aaaactggtt agatcctgct aaagaaataa     1020

agagacaact gagaaacctt ccatggctat tcacttttaa tgtgaagttt tatcctcctg     1080

atccttctca attgactgaa gatatcacca gatacttctt gtgccttcag ctccggcagg     1140

acattgcctc tggccgcctg ccctgctctt ttgtgactca tgctctcctg ggatcctaca     1200

ccctgcaggc tgaacttggt gactatgacc cagaagaaca tggcagcatc gacctcagtg     1260

aattccagtt tgcccctact cagactaagg agctggaaga gaaggtggca gagctgcaca     1320

aaacccacag gggcttatcg ccagcacaag ctgattccca gttcttagaa aatgcaaaga     1380

ggctttccat gtatggtgtt gacctacatc atgccaagga ctcagaaggt gtggacatca     1440

agctgggcgt gtgtgctaat ggacttctca tttacaaaga cagactgcga atcaatcgtt     1500

ttgcttggcc gaaaatctta aaaatttcct ataaacgcag taacttctac attaaagtca     1560

gaccggcaga gctggaacag tttgagagta ccattggatt caaactgcca aaccaccggg     1620

cagcgaaaag actatggaaa gtgtgcgtgg agcatcatac tttctacagg cttgtttctc     1680

cagagcagcc accaaaagcc aagttcctga ccttggggtc caaatttcgc tatagtggcc     1740

gcacccaagc acagacccgc caggccagca ccctcataga taggccagca ccacactttg     1800

agcgcacttc tagtaaacgg gtctccagga gtctagatgg agctccgatt ggtgtcatgg     1860

accaaagtct tatgaaggat tttcctggcg ctgctgggga gatttcagcc tatggacctg     1920

gacttgtcag cattgccgtg gtacaagatg gggacggcag gagggaagtg agaagcccaa     1980

ctaaagcccc acatttgcag ctcattgaag gaaagaaaaa ttccttgaga gtagaagggg     2040

ataatattta tgtcagacat agcaatttaa tgttggagga actggataag gcccaggagg     2100

acatactgaa acatcaggct agcattagtg aactcaagcg caattttatg gaatccacac     2160

ctgagccgcg ccctaatgaa tgggaaaaac gacgtatcac acctctgtcc ctacagacac     2220

aagggagttc acatgagact ctgaatatag tggaggagaa gaagcgggca gaggttggga     2280

aagacgaaag agtaatcaca gaagaaatga atggtaaaga gatatcacct gggagtggtc     2340

ctggggagat tcgtaaggtg gagcctgtga cacaaaaaga ctccacctcc ctgtcttctg     2400

agagcagcag cagcagcagt gagagtgagg aggaagacgt gggagagtac cgtccccacc     2460

accgagtgac cgagggcacc atcagggagg aacaggagta tgaagaagag gtggaggaag     2520

aaccccgccc ggcagccaag gtagtagaga gggaggaagc agtgcccgaa gccagcccag     2580

tcacacaagc aggtgccagt gtaatcacag tagaaacagt gatccaggaa aatgtaggtg     2640

cccaaaagat acccggagag aagagtgtac acgaaggcgc tcttaagcaa gacatgggag     2700

aagaagcaga ggaagagcca cagaaagtta acggagaggt gtcccatgtt gacattgatg     2760

ttttgccaca aattatttgt tgttcagagc caccagtggt aaaaacagag atggtaacaa     2820

tttctgatgc ctcacaaagg acagaaatct ccaccaagga agtccccatt gtccaaactg     2880

agaccaaaac catcacatat gagtctccac agattgatgg cggggctggt ggtgattcgg     2940

gcacgttact gaccgcacaa accatcacat ctgagtccgt gtcaacaacg acaaccacac     3000

acatcaccaa gactgtaaaa ggtggaattt ctgaaacaag aattgagaaa cgcattgtga     3060

tcacaggaga tggagatatt gatcatgacc aggcactggc tcaggcgatc agggaagcca     3120

gagagcagca ccctgacatg tcggtcacaa gagtggtggt acacaaagaa acagagttgg     3180

ctgaggaagg ggaagattaa gtaagaaagt cattttttaa acaacactca actttgtgaa     3240

cccctgaaga ttttttgacc gttccaagtc ttaatgccac accactattc cagcgaattt     3300

atgctacaac tggtaacaat gaccagaagc ctgaagaatt aaaatgccaa caccaaacct     3360

ttccttacca gctctggtct atattgctcc catgcattta atatattatt ttgttttata     3420

accacttcta aatattctca gttctttctt tttgttgttg ttaattaagg ggttttggtt     3480

ttgttttctg tttactttgt gtgcaactac ctgcttttaa tgactcactt tgatcaaatg     3540

acagtgaaca aagccagccc aagctggtaa ggtgctgttc acttgaacag gtgctgttgc     3600

gcagaaagga aactctgtga ctaatttaga tagtggcttt ccttcttctg gattcttttc     3660

attgaattct cacagtaaat atttacggag ttttcaaatt gcagcaaata tactgtatga     3720

gaaaatatta atacagatta aaagcctttc ttacatcttg aaaattttct aatatttgag     3780

aatttcacag ggatgttttt tatattggac ccttttgact ttccagtcct gtgactttct     3840

acttttagta gagagtcaga atctctggac tggagaataa tgaagaagtt cactgactgt     3900

gcactgtgct tagagaccct gccgcaccac agtgccaatg cttgtcagac acatgccctt     3960

cggcagcatt ccagaacagg agggaagaga aagagaaaac tttcttccct tctactaaaa     4020

gattcaggca gcttaaaacc ttagtgcttt ctttcttaac atacccacat ttcaattctt     4080

tccattattt gaacacttgg gtagaactct tgctttgtat taaacctctt tgtctacaca     4140

tgtaaaactt accttttgtt attgagcagg cctatctctt tcagatagtt ttatgattca     4200

cacaggtttg aggatgctgg ggagaggggg agggggctgt ggtggtgttc tgttggttac     4260

aagaaagtta taccatttaa agctggcacc agagacccga tagggactta ttaactatat     4320

tgaacatttt ttcctttgcc tttgacccta tgtatagtta cgatgccaga ttagatttat     4380

agcagcctca agttgtatta aatgatattt tgcttcctgt aatactatta taaaataaag     4440

tttgtttatt ctctaaa                                                    4457


<210>  22
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  22
tccgtagagt attagctaca gaaacctttc cattgccata ctgagaaact gcagcaggca       60

gtgtgcctac aggtctacaa agaaacttca gatcatcttc ttgagggaaa gaagctgaag      120

tgctacataa gatgcttgtg cttcataact ctcagaagct gcagattctg tataaatcct      180

tagaaaagag catccctgaa tccataaagg tatatggcgc cattttcaac ataaaagata      240

aaaacccttt caacatggag gtgctggtag atgcctggcc agattaccag atcgtcatta      300

cccggcctca gaaacaggag atgaaagatg accaggatca ttataccaac acttaccaca      360

tcttcaccaa agctcctgac aaattagagg aagtcctgtc atactccaat gtaatcagct      420

gggagcaaac tttgcagatc caaggttgcc aagagggctt ggatgaagca ataagaaagg      480

ttgcaacttc aaaatcagtg caggtagatt acatgaaaac catcctcttt ataccggaat      540

taccaaagaa acacaagacc tcaagtaatg acaagatgga gttatttgaa gtggatgatg      600

ataacaagga aggaaacttt tcaaacatgt tcttagatgc ttcacatgca ggtcttgtga      660

atgaacactg ggcctttggg aaaaatgaga ggagcttgaa atatattgaa cgctgcctcc      720

aggattttct aggatttggt gtgctgggtc cagagggcca gcttgtctct tggattgtga      780

tggaacagtc ctgtgagttg agaatgggtt atactgtccc caaatacaga caccaaggca      840

acatgttgca aattggttat catcttgaaa agtatctttc tcagaaagaa atcccatttt      900

atttccatgt ggcagataat aatgagaaaa gcctacaggc actgaacaat ttggggttta      960

agatttgtcc ttgtggctgg catcagtgga aatgcacccc caagaaatat tgttgattga     1020

ttccactgtc catttcaaat ctttcttatc agtaaaaaaa cattaattca aacacaagca     1080

ttgtgatcta cattagcaca aaatgcaact gattatctag gatctgtgta ttacttaagc     1140

tcacccttaa cagttttacc ttccttctcc tctgtattct tacagaaaat tagaagctca     1200

attttatggt ctcataattt cctttatgac agacatctca gaattaaaat cacccaaagc     1260

caatcattag tgccaagata accctttaac ggcaacactt tcttaaatga agactatttc     1320

tttcatgaaa aaattcactt ttatgacttt cttgttaaaa taaaaagtct gcttttaaaa     1380

aaaaaa                                                                1386


<210>  23
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  23
ggaccccggt tgctagggtg tgtctccttg gcctcctaga gggtggggat ccgtggtgct       60

tcttcgggaa cagcctcctg caggaagacc ctcgctggac ctttacctcg ctgcctagat      120

tccgaggaaa aggagatagg agacgaaaag ccagttggtt tggaaagcgg ccgattatcc      180

taaagggtag tgtgggagtc cagcacttcc atgcccctct ttgggtacta cggaagggag      240

atttccagca tcgtgtggaa catatgacca gggagtacac cttgagcgct tgtgtgcagt      300

tatcttttgg cggattatga aaaacagcac ttattattca ttaaaatgca aaagccccca      360

ctgcttcttc gaagaccctt acctccaaaa ttcactaagc tgtctttaca tgagaaaaaa      420

acccatacag ctaaaactgg taaaattgag tcactacatg tagcattcac tgaagatgaa      480

accacttcca ttaaaatgga tagaactcgt tttcctgatg ttttaagaaa tcaatcacta      540

acacctatca atatccaaaa tatctttctt gatcactgtg tacaagaaag agtgactgca      600

atttcatcac cccagaaatc tactaagcat gtccgtgagc agattccaga tactgctact      660

ggttccatat tttttccaca ttgtaattca gcttctactc gaatttttgg gaaacaaaca      720

aacaaaatgg aaagttcaag aaagtttaaa actatgaaag atgtttatac tgaaaaaagg      780

ctagaaaaca ttttaattct ttcttccaag ttttccaaac ctaaaagtac tcctggctca      840

gttatcgctc aaaaacttga gaaaatgcac cctaagcatc aacctttacc agagagtcca      900

ggctatactt atcagcacat ctcgagagac ttaagtgcaa cagtgccaag ccctccacct      960

atgactgtat ctatgaaacc agaaggacag tggcctgaac attttaaatc aactgctaca     1020

ttgacactaa gagttactga atttccaggt tttgtttcct tgccaacacc agttttacca     1080

agaaaacctc acaggcagtc tgtgatagaa actcttgtaa cagaaaatgg aaatatagaa     1140

agtgtcccaa agcaaatccc accaagacca cctgaaggtc tcaccaaaac tgaaaaaata     1200

gaatcagaga tacacgttgt acgtggtgaa ggttttaaga ctgttgcagc aacacgatat     1260

gaaacaataa cagccatgac caacctggcc atagtaaact gtcaagtata tgggagaaat     1320

gcacttaatc tgaagggctt ttttatccta aattgtccag acttaacacc tttggctttc     1380

cagttgatat atcttaattt atcatttaat gatcttcatt actttcccac agaaatatta     1440

tgtcttaaaa atttacaaat actgaaattg agaaataatc ctatcaaaga aattccttct     1500

gaaattcaac aacttgagtt ccttagaatt ttcaccattg cttttaattt aattactgtt     1560

cttccaattg ggttattttc cttgtcttat cttgaagaac ttgatgtttc ctataatgaa     1620

cttactttta ttccaaatga aattcagaaa ctcagatcac ttgaaaaact gactgttgat     1680

gggaatgaac tgagtttttt cccccatgga attttgaagc ttaacctgac aaaaattcag     1740

tttgagaata atttcactca tccttgtttt tggagagata attatttgaa taatccacaa     1800

caacttactc aaattatttc tttgttcatt gtccaaaata aactacataa attttatgat     1860

aagatcccag tagaagttca gaagttacta aaatggtga                            1899


<210>  24
<211>  5762
<212>  DNA
<213>  Homo sapiens

<400>  24
acagaaggca gttcacctct gctcccgaca gcctgggaac ccgcaagagc cccagcattt       60

gaagtctggt cttgtgaaac cccaccctcc tctggctgtg tgattgaatg ggatgccctc      120

gaggttcacc tcacctgaga gggttttggg cagatcagca gtaaggtgtt aaattttaga      180

agcctgaaaa ctccagaaga gaaaggccaa ccaactcaaa cttgaagaca tgaaatcccc      240

aaggagaacc actttgtgcc tcatgtttat tgtgatttat tcttccaaag ctgcactgaa      300

ctggaattac gagtctacta ttcatccttt gagtcttcat gaacatgaac cagctggtga      360

agaggcactg aggcaaaaac gagccgttgc cacaaaaagt cctacggctg aagaatacac      420

tgttaatatt gagatcagtt ttgaaaatgc atccttcctg gatcctatca aagcctactt      480

gaacagcctc agttttccaa ttcatgggaa taacactgac caaattaccg acattttgag      540

cataaatgtg acaacagtct gcagacctgc tggaaatgaa atctggtgct cctgcgagac      600

aggttatggg tggcctcggg aaaggtgtct tcacaatctc atttgtcaag agcgtgacgt      660

cttcctccca gggcaccatt gcagttgcct taaagaactg cctcccaatg gacctttttg      720

cctgcttcag gaagatgtta ccctgaacat gagagtcaga ctaaatgtag gctttcaaga      780

agacctcatg aacacttcct ccgccctcta taggtcctac aagaccgact tggaaacagc      840

gttccggaag ggttacggaa ttttaccagg cttcaagggc gtgactgtga cagggttcaa      900

gtctggaagt gtggttgtga catatgaagt caagactaca ccaccatcac ttgagttaat      960

acataaagcc aatgaacaag ttgtacagag cctcaatcag acctacaaaa tggactacaa     1020

ctcctttcaa gcagttacta tcaatgaaag caatttcttt gtcacaccag aaatcatctt     1080

tgaaggggac acagtcagtc tggtgtgtga aaaggaagtt ttgtcctcca atgtgtcttg     1140

gcgctatgaa gaacagcagt tggaaatcca gaacagcagc agattctcga tttacaccgc     1200

acttttcaac aacatgactt cggtgtccaa gctcaccatc cacaacatca ctccaggtga     1260

tgcaggtgaa tatgtttgca aactgatatt agacattttt gaatatgagt gcaagaagaa     1320

aatagatgtt atgcccatcc aaattttggc aaatgaagaa atgaaggtga tgtgcgacaa     1380

caatcctgta tctttgaact gctgcagtca gggtaatgtt aattggagca aagtagaatg     1440

gaagcaggaa ggaaaaataa atattccagg aacccctgag acagacatag attctagctg     1500

cagcagatac accctcaagg ctgatggaac ccagtgccca agcgggtcgt ctggaacaac     1560

agtcatctac acttgtgagt tcatcagtgc ctatggagcc agaggcagtg caaacataaa     1620

agtgacattc atctctgtgg ccaatctaac aataaccccg gacccaattt ctgtttctga     1680

gggacaaaac ttttctataa aatgcatcag tgatgtgagt aactatgatg aggtttattg     1740

gaacacttct gctggaatta aaatatacca aagattttat accacgagga ggtatcttga     1800

tggagcagaa tcagtactga cagtcaagac ctcgaccagg gagtggaatg gaacctatca     1860

ctgcatattt agatataaga attcatacag tattgcaacc aaagacgtca ttgttcaccc     1920

gctgcctcta aagctgaaca tcatggttga tcctttggaa gctactgttt catgcagtgg     1980

ttcccatcac atcaagtgct gcatagagga ggatggagac tacaaagtta ctttccatac     2040

gggttcctca tcccttcctg ctgcaaaaga agttaacaaa aaacaagtgt gctacaaaca     2100

caatttcaat gcaagctcag tttcctggtg ttcaaaaact gttgatgtgt gttgtcactt     2160

taccaatgct gctaataatt cagtctggag cccatctatg aagctgaatc tggttcctgg     2220

ggaaaacatc acatgccagg atcccgtaat aggtgtcgga gagccgggga aagtcatcca     2280

gaagctatgc cggttctcaa acgttcccag cagccctgag agtcccattg gcgggaccat     2340

cacttacaaa tgtgtaggct cccagtggga ggagaagaga aatgactgca tctctgcccc     2400

aataaacagt ctgctccaga tggctaaggc tttgatcaag agcccctctc aggatgagat     2460

gctccctaca tacctgaagg atctttctat tagcatagac aaagcggaac atgaaatcag     2520

ctcttctcct gggagtctgg gagccattat taacatcctt gatctgctct caacagttcc     2580

aacccaagta aattcagaaa tgatgacgca cgtgctctct acggttaatg tcatccttgg     2640

caagcccgtc ttgaacacct ggaaggtttt acaacagcaa tggaccaatc agagttcaca     2700

gctactacat tcagtggaaa gattttccca agcattacag tcgggagata gccctccttt     2760

gtccttctcc caaactaatg tgcagatgag cagcatggta atcaagtcca gccacccaga     2820

aacctatcaa cagaggtttg ttttcccata ctttgacctc tggggcaatg tggtcattga     2880

caagagctat ctagaaaact tgcagtcgga ttcgtctatt gtcaccatgg ctttcccaac     2940

tctccaagcc atccttgccc aggatatcca ggaaaataac tttgcagaga gcttagtgat     3000

gacaaccact gtcagccaca atacaactat gccattcagg atttcaatga cttttaagaa     3060

caatagccct tcaggcggcg aaacgaagtg tgtcttctgg aacttcaggc ttgccaacaa     3120

cacagggggg tgggacagca gtgggtgcta tgtagaagaa ggtgatgggg acaatgtcac     3180

ctgtatctgt gaccacctaa catcattctc catcctcatg tcccctgact ccccagatcc     3240

tagttctctc ctgggaatac tcctggatat tatttcttat gttggggtgg gcttttccat     3300

cttgagcttg gcagcctgtc tagttgtgga agctgtggtg tggaaatcgg tgaccaagaa     3360

ccggacttct tatatgcgcc acacctgcat agtgaatatc gctgcctccc ttctggtcgc     3420

caacacctgg ttcattgtgg tcgctgccat ccaggacaat cgctacatac tctgcaagac     3480

agcctgtgtg gctgccacct tcttcatcca cttcttctac ctcagcgtct tcttctggat     3540

gctgacactg ggcctcatgc tgttctatcg cctggttttc attctgcatg aaacaagcag     3600

gtccactcag aaagccattg ccttctgtct tggctatggc tgcccacttg ccatctcggt     3660

catcacgctg ggagccaccc agccccggga agtctatacg aggaagaatg tctgttggct     3720

caactgggag gacaccaagg ccctgctggc tttcgccatc ccagcactga tcattgtggt     3780

ggtgaacata accatcacta ttgtggtcat caccaagatc ctgaggcctt ccattggaga     3840

caagccatgc aagcaggaga agagcagcct gtttcagatc agcaagagca ttggggtcct     3900

cacaccactc ttgggcctca cttggggttt tggtctcacc actgtgttcc cagggaccaa     3960

ccttgtgttc catatcatat ttgccatcct caatgtcttc cagggattat tcattttact     4020

ctttggatgc ctctgggatc tgaaggtaca ggaagctttg ctgaataagt tttcattgtc     4080

gagatggtct tcacagcact caaagtcaac atccctgggt tcatccacac ctgtgttttc     4140

tatgagttct ccaatatcaa ggagatttaa caatttgttt ggtaaaacag gaacgtataa     4200

tgtttccacc ccagaagcaa ccagctcatc cctggaaaac tcatccagtg cttcttcgtt     4260

gctcaactaa gaacaggata atccaaccta cgtgacctcc cggggacagt ggctgtgctt     4320

ttaaaaagag atgcttgcaa agcaatgggg aacgtgttct cggggcaggt ttccgggagc     4380

agatgccaaa aagacttttt catagagaag aggctttctt ttgtaaagac agaataaaaa     4440

taattgttat gtttctgttt gttccctccc cctccccctt gtgtgatacc acatgtgtat     4500

agtatttaag tgaaactcaa gccctcaagg cccaacttct ctgtctatat tgtaatatag     4560

aatttcgaag agacattttc actttttaca cattgggcac aaagataagc tttgattaaa     4620

gtagtaagta aaaggctacc taggaaatac ttcagtgaat tctaagaagg aaggaaggaa     4680

gaaaggaagg aaagaaggga gggaaacagg gagaaaggga aaaagaagaa aaagagaaag     4740

atgaaaatag gaacaaataa agacaaacaa cattaagggc catattgtaa gatttccatg     4800

ttaatgatct aatataatca ctcagtgcaa cattgagaat ttttttttaa tggctcaaaa     4860

atggaaactg aaagcaagtc atggggaatg aatactttgg gcagtatctt cctgatgtct     4920

tcttagctaa gaggaggaaa aaaaggctga aaaaataggg aggaaattcc ttcatcagaa     4980

cgacttcaag tggataacaa tatttataag aaatgaatgg aaggaaatat gatcctcctg     5040

agactaactt tgtatgttaa ggtttgaact aagtgaatgt atctgcagag gaagtattac     5100

aaagatatgt cattagatcc aagtgctgat taaattttta tagtttatca gaaaagcctt     5160

atattttagt ttgttccaca ttttgaaagc aaaaaatata tatttgatat acccttcaat     5220

tgccaaattt gatatgttgc actgaagaca gaccctgtca tatatttaat ggcttcaagc     5280

aggtacttct ctgtgcatta tagaatagat tttaataatc ttatagcatt gtatattatt     5340

attgctgttg tcactgttat tattattgtg gatactggcc cttggtgtgt tgcatagctc     5400

cctatgtatt ctctgtttcc atctttaagt tcccagacca atatacatta agagttttgc     5460

atggtctaaa ttgtgtttat tccaaccacg tggaaagctc ctggaaagaa attttacatt     5520

cggttgttct gtgctcctaa tgacacttga ccttgttgaa caaatggcag agcctttccc     5580

aaggatttga ttgtttgtga attatctgca tgtgtgcttt tttttggtgt gtatttcatt     5640

aaaaaatata aatatttatg aaaattgcac gcatattaga gttaaccatg tactattgat     5700

acagcaacgc tacattgcaa ataaaagtcc gatcccaaaa ggagaatgag acaaaaaaaa     5760

aa                                                                    5762


<210>  25
<211>  6628
<212>  DNA
<213>  Homo sapiens

<400>  25
ctcctcggtg caacctatat aaggctcaca gtctgcgctc ctggtacacg cgcttcaact       60

tcggttggtg tgtgtcgaag aaacctgact gcgccctgag gagaacagcg gagaaggtcc      120

accgagcctg gcgaaaggtc cgctgagcgg gctgtcgtcc ggagccactc cgggctgcgg      180

agcacccagt ggagaccgcg cctggctcag gtgtgggacc ccatccttcc tgtcttcgca      240

gaggagtcct cgcgtgaaat aagcgggttt tgaaaacaaa aaaaagaagg agtggaagag      300

ggggccagga tccaggcctc catccccaca gaagtgaagc tacagctggg aggtctcctc      360

ccaccccaac cgtcaccctg ggtcccgact gcccacctcc tcctcctccc cctcccccca      420

acaacaacaa caacaacaac tccaagcaca ccggccataa gagtgcgtgt gtccccaaca      480

tgaccgaacg aagaagggac gagctctctg aagagatcaa caacttaaga gagaaggtca      540

tgaagcagtc ggaggagaac aacaacctgc agagccaggt gcagaagctc acagaggaga      600

acaccaccct tcgagagcaa gtggaaccca cccctgagga tgaggatgat gacatcgagc      660

tccgcggtgc tgcagcagct gctgccccac cccctccaat agaggaagag tgcccagaag      720

acctcccaga gaagttcgat ggcaacccag acatgctggc tcctttcatg gcccagtgcc      780

agatcttcat ggaaaagagc accagggatt tctcagttga tcgtgtccgt gtctgcttcg      840

tgacaagcat gatgaccggc cgtgctgccc gttgggcctc agcaaagctg gagcgctccc      900

actacctgat gcacaactac ccagctttca tgatggaaat gaagcatgtc tttgaagacc      960

ctcagaggcg agaggttgcc aaacgcaaga tcagacgcct gcgccaaggc atggggtctg     1020

tcatcgacta ctccaatgct ttccagatga ttgcccagga cctggattgg aacgagcctg     1080

cgctgattga ccagtaccac gagggcctca gcgaccacat tcaggaggag ctctcccacc     1140

tcgaggtcgc caagtcgctg tctgctctga ttgggcagtg cattcacatt gagagaaggc     1200

tggccagggc tgctgcagct cgcaagccac gctcgccacc ccgggcgctg gtgttgcctc     1260

acattgcaag ccaccaccag gtagatccaa ccgagccggt gggaggtgcc cgcatgcgcc     1320

tgacgcagga agaaaaagaa agacgcagaa agctgaacct gtgcctctac tgtggaacag     1380

gaggtcacta cgctgacaat tgtcctgcca aggcctcaaa gtcttcgccg gcgggaaact     1440

ccccggcccc gctgtagagg gaccttcagc gaccgggcca gaaataataa ggtccccaca     1500

agatgatgcc tcatctccac acttgcaagt gatgctccag attcatcttc cgggcagaca     1560

caccctgttc gtccgagcca tgatcgattc tggtgcttct ggcaacttca ttgatcacga     1620

atatgttgct caaaatggaa ttcctctaag aatcaaggac tggccaatac ttgtggaagc     1680

aattgatggg cgccccatag catcgggccc agttgtccac gaaactcacg acctgatagt     1740

tgacctggga gatcaccgag aggtgctgtc atttgatgtg actcagtctc cattcttccc     1800

tgtcgtccta ggggttcgct ggctgagcac acatgatccc aatatcacat ggagcactcg     1860

atctatcgtc tttgattctg aatactgccg ctaccactgc cggatgtatt ctccaatacc     1920

accatcgctc ccaccaccag caccacaacc gccactctat tatccagtag atggatacag     1980

agtttaccaa ccagtgaggt attactatgt ccagaatgtg tacactccag tagatgagca     2040

cgtctaccca gatcaccgcc tggttgaccc tcacatagaa atgatacctg gagcacacag     2100

tattcccagt ggacatgtgt attcactgtc cgaacctgaa atggcagctc ttcgagattt     2160

tgtggcaaga aatgtaaaag atgggctaat tactccaacg attgcaccta atggagccca     2220

agttctccag gtgaagaggg ggtggaaact gcaagtttct tatgattgcc gagctccaaa     2280

caattttact atccagaatc agtatcctcg cctatctatt ccaaatttag aagaccaagc     2340

acacctggca acgtacactg aattcgtacc tcaaatacct ggataccaaa cataccccac     2400

atatgccgcg tacccgacct acccagtagg attcgcctgg tacccagtgg gacgagacgg     2460

acaaggaaga tcactatatg tacctgtgat gatcacttgg aatccacact ggtaccgcca     2520

gcctccggta ccacagtacc cgccgccaca gccgccgcct ccaccaccac caccgccgcc     2580

gcctccatct tacagtaccc tgtaaatacc tgtcatgtcc ttcaggatct ctgccctcaa     2640

aatttattcc tgttcagctt ctcaatcagt gactgtgtgc taaattttag gctactgtat     2700

cttcaggcca cctgaggcac atcctctctg aaacggctat ggaaggttag ggccactctg     2760

gactggcaca catcctaaag caccaaaaga ccttcaacat tttctgagag caacagagta     2820

tttgccaata aatgatctct catttttcca ccttgactgc caatctaact aaaataatta     2880

ataagtttac tttccagcca gtcctggaag tctgggtttt acctgccaaa acctccatca     2940

ccatctaaat tataggctgc caaatttgct gtttaacatt tacagagaag ctgatacaaa     3000

cgcaggaaat gctgatttct ttatggaggg ggagacgagg aggaggagga catgactttt     3060

cttgcggttt cggtaccctc tttttaaatc actggaggac tgaggcctta ttaaggaagc     3120

caaaattatc ggtgcagtgt ggaaaggctt ccgtgatcct ctcgctgcac ccttagaaac     3180

ttcaccgtct tcaaactcca tttccatggt tctgttaatt ctcaaggagc agcaactcga     3240

ctggttctcc caggagcagg aaaaaccctt gtgacatgaa acatctcagg cctgaaaaga     3300

aagtgctctc tcagatggac tcttgcatgt taagactatg tcttcacatc atggtgcaaa     3360

tcacatgtac ccaatgactc cggctttgac acaacacctt accatcatca tgccatgatg     3420

gcttccacaa agcattaaac ctggtaacca gagattactg gtggctccag cgttgttaga     3480

tgttcatgaa atgtgaccac ctctcaatca cctttgaggg ctaaagagta gcacatcaaa     3540

aggactccaa aatcccatac ccaactctta agagatttgt cctggtactt cagaaagaat     3600

tttcatgagt gttcttaatt ggctggaaaa gcaccagctg acgttttgga agaatctatc     3660

catgtgtctg cctccatatg catctgggca tttcatcttc agtcccctca ttagactgta     3720

gcattaggat gtgtggagag aggagaaatg atttagcacc cagattcaca ctcctatgcc     3780

tggaaggggg acatctttga agaagaggaa ttagggctgt ggacactgtc ttgaggatgt     3840

ggacttcctt agtgagctcc acattacttg atggtaacca cttcaaaagg atcagaatcc     3900

acgtaatgaa aaaggtccct ctagaggatg gagctgatgt gaagctgcca atggatgaaa     3960

agcctcagaa agcaactcaa aggactcaaa gcaacggaca acacaagagt tgtcttcagc     4020

ccagtgacac ctctgatgtc ccctggaagc tttgtgctaa cctgggactg cctgacttcc     4080

tttagcctgg tcccttgcta ctaccttgaa ctgttttatc taacctctct ttttctgttt     4140

aattctttgc tactgccatt gaccctgctg caggatttgt gtcattttcc tgcctggttg     4200

ctgagactcc attttgctgc cacacacaga gatgtaagag gcaggcttta attgccaaag     4260

cacagtttga gcagtagaaa acaacatggt gtatatctca aattgcctga catgaagagg     4320

agtctaacgg tgaagtttca cttttcatca gcatcatctt tcacatgttc attatcatct     4380

gctcttattc ttgcatgttt aaacacttaa aatttttagt ataattttta gtgtgttttg     4440

aagtggtgac taggctttca aaaacttcca ttgaattaca aagcactatc cagttcttat     4500

tgttaaacta agtaaaaatg ataagtaaca tagtgtaaaa tattccttta ctgtgaactt     4560

cttacaatgc tgtgaatgag aggctcctca gaactggagc atttgtataa taattcatcc     4620

tgttcatctt caattttaac atcatatata atttcaattc tatcaattgg gcctttaaaa     4680

atcatataaa aggatataaa atttgaaaag agaaacctaa ttggctattt aatccaaaac     4740

aacttttttt ttccttcaat ggaatcagaa agcttgtcaa tcactcatgt gttttagagt     4800

aattactttt aaaatggtgc atttgtgctt ctgaactatt ttgaagagtc acttctgttt     4860

acctcaagta tcaattcatc ctccatacat ttgaattcaa gttgtttttt tgtcaaattt     4920

acagttgtca attgatcttc aagctgcagg gtgcctagaa atgggccgtt gtctgtagcc     4980

ctggcatgtg cacacggaca tttgccacca ctgcaagcaa aagtctggag aagttcacca     5040

acgacaagaa cgattaggga aaatatgctg ctgtgggtta acaactcaga aagtccctga     5100

tccacatttg gctgtttact aaagcttgtg attaactttt tggcagtgtg tactatgctc     5160

tattgctata tatgctatct ataaatgtag atgttaagga taagtaattc taaatttatt     5220

attctatagt tttgaagttt ggttaagttt cctttcactc aattgattta ttttgttgtt     5280

aatcaaattt atgttaattg gatcctttaa attttttttg gcattttcca acaaaaatgg     5340

ctttattcat aagaaaggaa aaaaatcaat ggaatttgat atctaaagaa gttagaaagg     5400

gagcaaaata aaaaacataa aggagataga tgaattagta agcaaatcag tagtcgagtt     5460

tttcaaactg gcaaaattaa ttaattgact tttagcccaa atttacattg ttaattaaat     5520

caagaaggaa gaagatctaa gagctcccat tgataggcaa gcctagagag aactagctaa     5580

atttatcatg ctaggatatt gaaacacaga aagtttacat acatttatga agggtcaatt     5640

tagtttggac agtgaggtat ttgtcttagt ggaaaaaagg agaattagtc tgatcaaatc     5700

gtgaagtaat acagtgaact tgcaggtgca caaaataaga gggccacatc tatatggtgc     5760

agtctggaat tctgtttaag tttgtaggta cctcttggac ttctgaattg atccagttgt     5820

catccaccac agacatctca catcagatac agacagttcc aagattgaca acagagaaca     5880

acctgctgga aagacctggg cagaaatgga gagccctgcg ggaaccatgc tacattttca     5940

tctaaagaga gaatgcacat ctgatgagac tgaaagttct ttgttgtttt agattgtaga     6000

atggtattga attggtctgt ggaaaattgc attgctttta tttctttgtg taatcaagtt     6060

taagtaatag gggatatata atcataagca ttttagggtg ggagggacta ttaagtaatt     6120

ttaagtgggt ggggttattt agaatgttag aataatatta tgtattagat atcgctataa     6180

gtggacatgc gtacttactt gtaacccttt accctataat tgctatcctt aaagatttca     6240

aataaactcg gagggaactg cagggagacc aacttattta gagcgaattg gacatggata     6300

aaaaccccag tgggagaaag ttcaaaggtg attagattaa taatttaata gaggatgagt     6360

gacctctgat aaattactgc tagaatgaac ttgtcaatga tggatggtaa attttcatgg     6420

aagttataaa agtgataaat aaaaaccctt gcttttaccc ctgtcagtag ccctcctcct     6480

accactgaac cccattgccc ctacccctcc ttctaacttt attgctgtat tctcttcact     6540

ctatatttct ctctatttgc taatattgca ttgctgttac aataaaaatt caataaagat     6600

ttagtggtta agtgcaaaaa aaaaaaaa                                        6628


<210>  26
<211>  7582
<212>  DNA
<213>  Homo sapiens

<400>  26
tctttcactc ttgggcctag cgaggcagct tatttttcct ttttctttca ttggtcacag       60

ttatttcttt tcagtgtgtc atcttctcta agtttctgag ggagtgttag cttgaggcct      120

tgccttgaca taatcagata taatcagaaa aatgaaaaat tccataggaa agagaactat      180

tttagccaag gtgtgcgaga gaaataccgc cactttcaag cactgttttc ttctactgga      240

gtctgctcaa tagggacgtc agctttgctg gggcttcctt tgacaagaga atcagaaccg      300

actggtgaca tttgtttcaa tgaaagcaac agtgtgaaga gtaagtagtt tttcctatta      360

ttcatctcac tcagtggaga taatgaactc ctctccactg ccaagatgag aaactaccat      420

ttcttacaca tggacacaaa gatgagaaca ataaacactg agacttcaaa aaggagggaa      480

ggagaaagag gaacaagact tgaaatctac ctatcagaac ttgcaattta ttctgatcaa      540

caatttgccc agctaaagta ctacatctgc cccctcttcc tgtggctgta ggggcacagc      600

aaaggtcact ggtctaacct ccttaaaggg actccgctaa cagaaaccac caaatggagt      660

ggagaaaaag aaaagggatc ccctatcccc aactccagcc atctagatta agaaaagcca      720

gctgactgga cagtagcaca gcccagtcac ctcatggaca aatttcctag gaaagaacct      780

ctcccatcta ttctacttat cactctcctt tgaggttccg gccacagatc ttcgcctgct      840

gctggaaatg gccctctcag tggactcatc gtggcatcgg tggcagtgga gagtcagaga      900

tggcttcccc cattgtccat cggaaaccac accgctgctc tctccagaga aagggagaca      960

gagctacaac ttgacacagc agcgggtcgt gttccccaac aacagcatat tccatcaaga     1020

ttgggaagag gtctccagga gataccctgg caacagaacc tgcacaacca aatacaccct     1080

cttcaccttc ctgccccgga atctctttga gcaatttcat agatgggcta acctctattt     1140

cctgttcctg gtgattttga actggatgcc ctccatggaa gtcttccaca gagaaatcac     1200

catgttacca ttggccattg tcctgttcgt catcatgatc aaggatggca tggaggactt     1260

caagagacac cgctttgata aagcaataaa ctgctccaac attcgaattt atgaaagaaa     1320

agagcagacc tatgtgcaga agtgctggaa ggatgtgcgc gtgggagact tcatccaaat     1380

gaaatgcaat gagattgtcc cagcagacat actcctcctt ttttcctctg accccaatgg     1440

gatatgccat ctggaaactg ccagcttgga tggagagaca aacctcaagc aaagatgtgt     1500

cgtgaagggc ttctcacagc aggaggtaca gttcgaacca gagcttttcc acaataccat     1560

cgtgtgtgag aaacccaaca accacctcaa caaatttaag ggttatatgg agcatcctga     1620

ccagaccagg actggctttg gctgtgagag tcttctgctt cgaggctgca ccatcagaaa     1680

caccgagatg gctgttggca ttgtcatcta tgcaggccat gagacgaaag ccatgctgaa     1740

caacagtggc ccccggtaca aacgcagcaa gattgagcgg cgcatgaata tagacatctt     1800

cttctgcatt gggatcctca tcctcatgtg ccttattgga gctgtaggtc acagcatctg     1860

gaatgggacc tttgaagaac accctccctt cgatgtgcca gatgccaatg gcagcttcct     1920

tcccagtgcc cttgggggct tctacatgtt cctcacaatg atcatcctgc tccaggtgct     1980

gatccccatc tctttgtatg tctccattga gctggtgaag ctcgggcaag tgttcttctt     2040

gagcaatgac cttgacctgt atgatgaaga gaccgattta tccattcaat gtcgagccct     2100

caacatcgca gaggacttgg gccagatcca gtacatcttc tccgataaga cggggaccct     2160

gacagagaac aagatggtgt tccgacgttg caccatcatg ggcagcgagt attctcacca     2220

agaaaatgct aagcgactgg agaccccaaa ggagctggac tcagatggtg aagagtggac     2280

ccaataccaa tgcctgtcct tctcggctag atgggcccag gatccagcaa ctatgagaag     2340

ccaaaaaggt gctcagcctc tgaggaggag ccagagtgcc cgggtgccca tccagggcca     2400

ctaccggcaa aggtctatgg ggcaccgtga aagctcacag cctcctgtgg ccttcagcag     2460

ctccatagaa aaagatgtaa ctccagataa aaacctactg accaaggttc gagatgctgc     2520

cctgtggttg gagaccttgt cagacagcag acctgccaag gcttccctct ccaccacctc     2580

ctccattgct gatttcttcc ttgccttaac catctgcaac tctgtcatgg tgtccacaac     2640

caccgagccc aggcagaggg tcaccatcaa accctcaagc aaggctctgg ggacgtccct     2700

ggagaagatt cagcagctct tccagaagtt gaagctattg agcctcagcc agtcattctc     2760

atccactgca ccctctgaca cagacctcgg ggagagctta ggggccaacg tggccaccac     2820

agactcggat gagagagatg atgcatctgt gtgcagtgga ggtgactcca ctgatgacgg     2880

tggctacagg agcagcatgt gggaccaggg cgacatcctg gagtctgggt caggcacttc     2940

cttggaggag gcattggagg ccccagccac agacctggcc aggcctgagt tctgttacga     3000

ggctgagagc cctgatgagg ccgccctggt gcacgctgcc catgcctaca gcttcacact     3060

agtgtcccgg acacctgagc aggtgactgt gcgcctgccc cagggcacct gcctcacctt     3120

cagcctcctc tgcaccctgg gctttgactc tgtcaggaag agaatgtctg tggttgtgag     3180

gcacccactg actggcgaga ttgttgtcta caccaagggt gctgactcgg tcatcatgga     3240

cctgctggaa gacccagcct gcgtacctga cattaatatg gaaaagaagc tgagaaaaat     3300

ccgagcccgg acccaaaagc atctagactt gtatgcaaga gatggcctgc gcacactatg     3360

cattgccaag aaggttgtaa gcgaagagga cttccggaga tgggccagtt tccggcgtga     3420

ggctgaggca tccctcgaca accgagatga gcttctcatg gaaactgcac agcatctgga     3480

gaatcaactc accttacttg gagccactgg gatcgaagac cggctgcagg aaggagttcc     3540

agatacgatt gccactctgc gggaggctgg gatccagctc tgggtcctga ctggagataa     3600

gcaggagaca gcggtcaaca ttgcccattc ctgcagactg ttaaatcaga ccgacactgt     3660

ttataccatc aatacagaga atcaggagac ctgtgaatcc atcctcaatt gtgcattgga     3720

agagctaaag caatttcgtg aactacagaa gccagaccgc aagctctttg gattccgctt     3780

accttccaag acaccatcca tcacctcaga agctgtggtt ccagaagctg gattggtcat     3840

cgatgggaag acattgaatg ccatcttcca gggaaagcta gagaagaagt ttctggaatt     3900

gacccagtat tgtcggtccg tcctgtgctg ccgctccacg ccactccaga agagtatgat     3960

agtcaagctg gtgcgagaca agttgcgcgt catgaccctt tccataggtg atggagcaaa     4020

tgatgtaagc atgattcaag ctgctgatat tggaattgga atatctggac aggaaggcat     4080

gcaggctgtc atgtccagcg actttgccat cacccgcttt aagcatctca agaagttgct     4140

gctcgtgcat ggccactggt gttactcgcg cctggccagg atggtggtgt actacctcta     4200

caagaacgtg tgctacgtca acctgctctt ctggtatcag ttcttctgtg gtttctccag     4260

ctccaccatg attgattact ggcagatgat attcttcaat ctcttcttta cctccttgcc     4320

tcctcttgtc tttggagtcc ttgacaaaga catctctgca gaaacactcc tggcattgcc     4380

tgagctatac aagagtggcc agaactctga gtgctataac ctgtcgactt tctggatttc     4440

tatggtggat gcattctacc agagcctcat ctgtttcttt atcccttacc tggcctataa     4500

gggctctgat atagatgtct ttacctttgg gacaccaatc aacaccatct ccctcaccac     4560

aatccttttg caccaggcaa tggaaatgaa gacatggacc attttccacg gagtcgtgct     4620

cctcggcagc ttcctgatgt actttctggt atccctcctg tacaatgcca cctgcgtcat     4680

ctgcaacagc cccaccaatc cctattgggt gatggaaggc cagctctcaa accccacttt     4740

ctacctcgtc tgctttctca caccagttgt tgctcttctc ccaagatact ttttcctgtc     4800

tctgcaagga acttgtggga agtctctaat ctcaaaagct cagaaaattg acaaactccc     4860

cccagacaaa agaaacctgg aaatccagag ttggagaagc agacagaggc ctgcccctgt     4920

ccccgaagtg gctcgaccaa ctcaccaccc agtgtcatct atcacaggac aggacttcag     4980

tgccagcacc ccaaagagct ctaaccctcc caagaggaag catgtggaag agtcagtact     5040

ccacgaacag agatgtggca cggagtgcat gagggatgac tcatgctcag gggactcctc     5100

agctcaactc tcatccgggg agcacctgct gggacctaac aggataatgg cctactcaag     5160

aggacagact gatatgtgcc ggtgctcaaa gaggagcagc catcgccgat cccagagttc     5220

actgaccata tgaggagctg cagaaatctg tacaaactca acagaggcca cctagtcact     5280

ggtccacata acccttgacc ccttcttctt catagaggaa acaatgtgcc agtcttattc     5340

ttttcttcaa caaccttgac ttccatggag gaagtgctgg ccccaagggg tctgacacaa     5400

agacgggaaa cccagtcggc ctctagtttt ctgctgctct caggcagcac atcttgcaaa     5460

cagtttggag aaggaggctg tttttgttga atcgagttct caaatcggtt tagaccaaag     5520

ccattcttct gaccctctag ataagcgtag cctacaaccc agtgccgtaa gtttccaaga     5580

ttcaagaagt gtatcaaccc aggcaatatc tcaggatatg gaagtttctg ggtttattta     5640

cccctcagtg cccagagtta aagtttcaga agagacttgt gcacataagg gcttcatctc     5700

aagtgtattg cagtaatggc tgaatcgggg ttaacatccc ttccaggcac agcgagttgg     5760

ttctgctttt tgcctgtaag ccaaagaaaa gccacatcta aaaagctact actaaaagcc     5820

agaaagaaaa gtggatttga actcagtgtc acagactctt ctgagtgttt tagggtcaca     5880

gctagtgtaa gaggcatgaa gaatagacat gcaaaaggga acgggtgcac cagagacccc     5940

tgttttggct gacagaccat atgtcccacc agctggggaa tctgacaaga ggacataggt     6000

ggcactcttt ttttaaagct atttattgta tctattttta aataaaattg cccatcctca     6060

ttcagctctt agaacaaaag caaaaaaccc tgtaaatcag gagatataag cacatctgca     6120

cccagaatag gcccatatga tagggcaacc ctgagcttaa acaatgacat cttcaagggt     6180

agaactaatc tgaaacccca ttcagcctat tccagaatgg ggataggctg aaaccccctt     6240

ccagcctctg gaagacactg gcctgcatca gttagagtca gagcaagtgt cacttcacag     6300

ggaaaagaag gattatatag acttcctatc cctagagttt ataaatgtca actatataaa     6360

aaaagctcaa aacagtgtta aaggaatgaa cagtagaatt ttaataggct gtccaaagaa     6420

gccaggtctg ctgtgggcaa gtatagccta accctagtct tgtaaaataa gccagaaagg     6480

gttactgagc caccttaagc tagtacctat atagtaggca aaaagtacag aaatagatgc     6540

aataagtgtg gtgagtcttt gagcctacga gtcatgccac cagccataag ttgacctatc     6600

acttgagaac ctcctcagca aagatgccag aaaacattca atcaagttgg caaatgacac     6660

agggagctgg ccctctgacc atcttcctgg caaacctgga ctggaagggc catttgcagc     6720

actgtcctgg agctaataca ctgtttcact gcctctgcca tataatgatg ccagcactag     6780

ccagctggtg ggtatttgga ggaatcctgc atgaggattg cccaataagg ggcaggtaca     6840

catacctggc aaagtgatga tgatgtgaat tgtttccagt gaggggattg agtcaaaact     6900

tggatctcag gtacctcaat ttttccccca atttctggct actactaaaa gccagaaaga     6960

acagaacagt ggcctcagga gatctgagtt tgaatccttg ctctctagga tgcaggtggc     7020

ttgaagcaga atgccacacc tgcaagttga ttagaactgc ctttcttccc aggcttgaca     7080

taggtattaa gtcaaaatta catgaaaccc agtggtaaaa aagcctctga aagctgtaac     7140

accctcagta ataacaaaag ggatttttat ttcacagcta aagggaaaat aggtggagaa     7200

gttaaaaaat aatgtctgat cctgttccta agttccaaac tatagccaac actctgatgc     7260

tgctcttttt cttgtaggac caaccgtccc agtttgcctg ggactttctc atttttacag     7320

agtcccaaat cctaggaaac tggagcaact ggtacaactg gtcacctact cttgcccctc     7380

tgtaaatcaa gccaactgtg accatccaat gtgccatctt acagggaaaa gttataacca     7440

ctattcccct ataacataat gctaatgatt gtacttagta catttttata cttttatgat     7500

attttactga ttggaaatgt catcctttat taaaaataaa catggttttc catagttgcc     7560

tgccaaaaaa aaaaaaaaaa aa                                              7582


<210>  27
<211>  2158
<212>  DNA
<213>  Homo sapiens

<400>  27
attcataaaa cgcttgttat aaaagcagtg gctgcggcgc ctcgtactcc aaccgcatct       60

gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg aacgagcagt      120

gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc ctcggcccct      180

cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag actacgaggc      240

gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt actaccactc      300

acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact tctgcacgga      360

cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga ccagtccgga      420

cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc agaccagagc      480

ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg ctggcgttgt      540

gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg tggaacagtt      600

atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga tggctgcagc      660

caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga cagaccaact      720

agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg agaaggaaaa      780

actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg acctgggctt      840

cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag aggttgccac      900

cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc ccaagccctc      960

agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct ttgatgactt     1020

cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg tgccagacat     1080

ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg gctccctggg     1140

gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca cctgtactcc     1200

cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg actccttccc     1260

cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct ctgactcgct     1320

cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag ccggcaccca     1380

caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt ccctagaggg     1440

ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct gtgggcctca     1500

aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag atgtagcaaa     1560

acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt agtagcatgt     1620

tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc atagcattaa     1680

ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca aattgtatct     1740

agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt ctgattagaa     1800

atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata gaaataaata     1860

gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat gttactgatc     1920

atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga aaacgtttta     1980

ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt tattttattt     2040

ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa atttaagcat     2100

tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat gcgaccaa       2158


<210>  28
<211>  2607
<212>  DNA
<213>  Homo sapiens

<400>  28
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct       60

catccactgc tcgctgcctc tccagatctt cagttgcttc aggccatttg aacgtatatg      120

agccggtcgt aggggatatg atggcttagc ttgggctcag aggcctgaaa atcgccccca      180

ccaatcacct gtttccccca atctaccctc ctgaaggtca ctgacaaaga cttcattgtc      240

tcctaggaga ggctgccata tatccagggc tgacgtaatt ccatcttaat atcagttaca      300

ttataaaaat ttacctcgtg cctgaggccc cagagcccaa gggtgcaaag cagtaattgg      360

tcaaagttca acttccctcc cactctgggc tcaggctgtc ccctgagggc ctgtgttttg      420

agtctctttc cagaaccttg gtgtgaactt aggtcttggc gtcgggatcc cttttcgtca      480

cactcaggtg acctacaggg agctccgctc gacactgcaa ggcttagacc agttcggtcc      540

aacagagaaa gcaggcaacc accatgtcat ttgaaaacag tttcatcggg atataattcg      600

caacccatac agtgaatcca tttaagatac tctgacccat ggatcccctg ggtgcagcca      660

agccacaatg gccatggcgc cgctgtctgg ccgcactgct atttcagctg ctggtggctg      720

tgtgtttctt ctcctacctg cgtgtgtccc gagacgatgc cactggatcc cctagggctc      780

ccagtgggtc ctcccgacag gacaccactc ccacccgccc caccctcctg atcctgctat      840

ggacatggcc tttccacatc cctgtggctc tgtcccgctg ttcagagatg gtgcccggca      900

cagccgactg ccacatcact gccgaccgca aggtgtaccc acaggcagac acggtcatcg      960

tgcaccactg ggatatcatg tccaacccta agtcacgcct cccaccttcc ccgaggccgc     1020

aggggcagcg ctggatctgg ttcaacttgg agccaccccc taactgccag cacctggaag     1080

ccctggacag atacttcaat ctcaccatgt cctaccgcag cgactccgac atcttcacgc     1140

cctacggctg gctggagccg tggtccggcc agcctgccca cccaccgctc aacctctcgg     1200

ccaagaccga gctggtggcc tgggcggtgt ccaactggaa gccggactca gccagggtgc     1260

gctactacca gagcctgcag gctcatctca aggtggacgt gtacggacgc tcccacaagc     1320

ccctgcccaa ggggaccatg atggagacgc tgtcccggta caagttctac ctggccttcg     1380

agaactcctt gcaccccgac tacatcaccg agaagctgtg gaggaacgcc ctggaggcct     1440

gggccgtgcc cgtggtgctg ggccccagca gaagcaacta cgagaggttc ctgccacccg     1500

acgccttcat ccacgtggac gacttccaga gccccaagga cctggcccgg tacctgcagg     1560

agctggacaa ggaccacgcc cgctacctga gctactttcg ctggcgggag acgctgcggc     1620

ctcgctcctt cagctgggca ctggatttct gcaaggcctg ctggaaactg cagcaggaat     1680

ccaggtacca gacggtgcgc agcatagcgg cttggttcac ctgagaggcc ggcatggtgc     1740

ctgggctgcc gggaacctca tctgcctggg gcctcacctg ctggagtcct ttgtggccaa     1800

ccctctctct tacctgggac ctcacacgct gggcttcacg gctgccagga gcctctcccc     1860

tccagaagac ttgcctgcta gggacctcgc ctgctgggga cctcgcctgt tggggacctc     1920

acctgctggg gacctcacct gctggggacc ttggctgctg gaggctgcac ctactgagga     1980

tgtcggcggt cggggacttt acctgctggg acctgctccc agagaccttg ccacactgaa     2040

tctcacctgc tggggacctc accctggagg gccctgggcc ctggggaact ggcttacttg     2100

gggccccacc cgggagtgat ggttctggct gatttgtttg tgatgttgtt agccgcctgt     2160

gaggggtgca gagagatcat cacggcacgg tttccagatg taatactgca aggaaaaatg     2220

atgacgtgtc tcctcactct agaggggttg gtcccatggg ttaagagctc accccaggtt     2280

ctcacctcag gggttaagag ctcagagttc agacaggtcc aagttcaagc ccaggaccac     2340

cacttatagg gtacaggtgg gatcgactgt aaatgaggac ttctggaaca ttccaaatat     2400

tctggggttg agggaaattg ctgctgtcta caaaatgcca agggtggaca ggcgctgtgg     2460

ctcacgcctg taatcccagc actttgggag gctgaggtag gaggattgat tgaggccaag     2520

agttaaagac cagcctggtc aatatagcaa gaccacgtct ctaaataaaa aataataggc     2580

cggccaggca aaaaaaaaaa aaaaaaa                                         2607


<210>  29
<211>  6769
<212>  DNA
<213>  Homo sapiens

<400>  29
aattctgctg ggagtcgcat cctacctgtt tgggaggtgc actgcctttc cacactctcc       60

cttctgtact cagccagctg ctgctgaggt gggaggaaaa gtcctggctg ggagaattga      120

gctagtgcag cacacgtaaa aaagcgattc cgatgggtcc tttgaaagct tttctcttct      180

ccccttttct tctgcggagt caaagtagag gggtgaggtt ggtcttcttg ttactgaccc      240

tgcatttggg aaactgtgtt gataaggcag atgatgaaga tgatgaggat ttaacggtga      300

acaaaacctg ggtcttggcc ccaaaaattc atgaaggaga tatcacacaa attctgaatt      360

cattgcttca aggctatgac aataaacttc gtccagatat aggagtgagg cccacagtaa      420

ttgaaactga tgtttatgta aacagcattg gaccagttga tccaattaat atggaatata      480

caatagatat aatttttgcc caaacctggt ttgacagtcg tttaaaattc aatagtacca      540

tgaaagtgct tatgcttaac agtaatatgg ttggaaaaat ttggattcct gacactttct      600

tcagaaactc aagaaaatct gatgctcact ggataacaac tcctaatcgt ctgcttcgaa      660

tttggaatga tggacgagtt ctgtatactc taagattgac aattaatgca gaatgttatc      720

ttcagcttca taactttccc atggatgaac attcctgtcc actggaattt tcaagctatg      780

gataccctaa aaatgaaatt gagtataagt ggaaaaagcc ctccgtagaa gtggctgatc      840

ctaaatactg gagattatat cagtttgcat ttgtagggtt acggaactca actgaaatca      900

ctcacacgat ctctggggat tatgttatca tgacaatttt ttttgacctg agcagaagaa      960

tgggatattt cactattcag acctacattc catgcattct gacagttgtt ctttcttggg     1020

tgtctttttg gatcaataaa gatgcagtgc ctgcaagaac atcgttgggt atcactacag     1080

ttctgactat gacaaccctg agtacaattg ccaggaagtc tttacctaag gtttcttatg     1140

tgactgcgat ggatctcttt gtttctgttt gtttcatttt tgtttttgca gccttgatgg     1200

aatatggaac cttgcattat tttaccagca accaaaaagg aaagactgct actaaagaca     1260

gaaagctaaa aaataaagcc tcgatgactc ctggtctcca tcctggatcc actctgattc     1320

caatgaataa tatttctgtg ccgcaagaag atgattatgg gtatcagtgt ttggagggca     1380

aagattgtgc cagcttcttc tgttgctttg aagactgcag aacaggatct tggagggaag     1440

gaaggataca catacgcatt gccaaaattg actcttattc tagaatattt ttcccaaccg     1500

cttttgccct gttcaacttg gtttattggg ttggctatct ttacttataa aatctacttc     1560

ataagcaaaa atcaaaagaa gtctgactaa attcagtaga atcttttgtg cttcagtaac     1620

ttgaagttta aatttaaaat gcagagagac caatggttaa aatgtgaata gtattgtaac     1680

tattttaagg ccttcagaag taaataaagt agcagctttc aggctaattt acgtgaaact     1740

gattagttgc aaaatccagt aggttaaaat actcacatat ttttacttaa attttcttta     1800

atttacttat atgttattat aattttgaat ttttaagttc tatgattcat gttttaaaga     1860

tggaataatt ttaatacata ttttgtttaa atataatcta taattgtttt gtaatgtaag     1920

actaattact aatatttatg tagcaacttt tgtgccagaa aaaagactgt taatttgttt     1980

tttcttgctt ttcatttgat taccctgctt gaaatacagt tagttgataa cataaagcca     2040

tagttttctt ggattttctt ccaagatatt gtattcccaa gaagaaattg atttattttt     2100

aaactatcag ttactgaaga cttatgaaaa ggtcaatttt tacctgtctt ttaatccagt     2160

ccattttctg acacaatatt aaacagaacg ccagttgcat ttactttggt gatttgcaaa     2220

cttggaatga agccaccagt cattttttaa gaatgcaaga tgaaaaaatc aggtaaaatc     2280

taaccatttt attctctgct tcatagcatt tataatgtat gatgaggtta acactgaaat     2340

attaaaatct gcaaatgcac attaatgcaa attaaatgca gagagaaatg attatttttt     2400

tctttatgtt ttatgaaagt gttgcagtcc ctaaaataaa aatattgagg aacattgctt     2460

gtatttactc acgtggttaa aaaattatta cctggcaaac tgagttgccg gtcatattga     2520

ggacaaaatc ttaaatatgt gctattagca ttgtttttag actagtaata tgcagaaaac     2580

agttttaggc ctgcgttaca tattgcctct tccagctcca aagttttgga ccctgtcagt     2640

tttgcaacta cattatacat tattataata ttcttttttt tttctagaaa ctgggggcag     2700

cctcaaaatc atgttaaaga gggagttttg ttagaggcat ctttaatgaa catgaatgtg     2760

agtgctctct aaattcttag catctcactg gatgtaaaat ctatcagtta atagttttaa     2820

aaatgtctct tttgttaaga ataaatttag gcttcaatca ttataatcct gtaagtagct     2880

tgacatacca attgtttata agattcatca cataaatttc tggagaacca ccaggtttag     2940

cttggaaata acctttaaag attgtttctg ttgccaagac caatgaccat gatgaagagt     3000

tttatgatca cagcctatct tacttaaggt ttgagaggaa acctgtcacc tctgcaattg     3060

ttactctagt ttttaatgtt ataattccgc tgcgtggtta gtgaatgtct ggcatgatta     3120

tacacgtgta ttggaaatat ctagtttttt aaatttttaa ttaatttatt tataatttac     3180

tgtgtgttcc cagctaactc tatttttttt ttcacttgct cataaacttc tggaaaaaaa     3240

taagcatgaa tcaaatggta atgcccaata tccaccgaca ctgcttttct tgaatgaaca     3300

gccaaactaa actttggcca tctatatatt catttacaga ttattcatac attcatttta     3360

ataacattga gtactgatgg atgttttgaa agtgagcatt catttaagga taaataaaaa     3420

ataaagtagt aataaagaat aaaatacttt actaaaatat tgtatggcta ttttcatgtt     3480

tgaagctata gcttactatc atgagacagt tttgattttg ggactctttc aagtgtatct     3540

gagcatgact gtattttaaa atacttaaaa gtgcttgata taaatagctt ttccttctga     3600

accacgttct atgtaaaaga aaaaaaatag ctttgatttt ctcactggtg tttcattaac     3660

ttggttttaa atgttgacaa tatttacaag tggaaataaa atttgtaaat atatgaaaga     3720

tgcctttcct tgtatatacc atcaagcaag cactttgttt tcaaagcaag tggtattttg     3780

atcagtttta tttaaatgtg tgatcagaaa gaatggcgta caaatcttat tatttctaaa     3840

aataagaata aaaaggtaaa actacattta gacttctttc tcaagaaatc aaatacagct     3900

ttttttcaaa gctgattcag ttcatttcct gttcctctat tccaagtata agtttcacca     3960

ccttgagaaa taattttttt aaaaaatctt cctctttctc tggggagtta tataataatt     4020

tattgaattt attggaactt gattttcctg gatgctttca atgtttttaa tgctaacata     4080

gaccccaaaa ttagatataa agaattggga aggatacctg gagcacaagg aataagatca     4140

tttgtaaaaa tgtttgttta tatagaccta tcctctaaat atgtgacaag gatctagaaa     4200

ttctgagagg ggaaaatgtg attttggatt tacaatgaca gggtaatatt ttatttatct     4260

tcgaattcca tggacaaaat taggctcact taaattaatt tttgtaaacc caagtaagtt     4320

ctaaaaaaaa gtaaaaaata catagaatac ttgagaattt agcagggaca gggaaaaatt     4380

tcccagtaag tctgaagtct tgatgtaagt gggaattaga taactaattg gaggcatttt     4440

attttaagtt aaagacagat ttctttaata agtttttaaa attgatcaac tttaaattaa     4500

gcacagtaaa tgtgtataaa tatgaaggca atcataagga ttttttcact tgtgtttcca     4560

tattctggca ttagtatatc atcataaaat agacaatgtt tttgtctcaa gaacaagaat     4620

aaaattgaaa tctgcattca tgccaattca gcataaaaaa gaataggcta cagttctctc     4680

acaccaaggg ccccatagtt ataaatgtga aattatattc caggtcaaaa tttgtgaaaa     4740

atacacaaaa cactttgatt ttacaagaga ggagctttaa ataagatgat tttagtagat     4800

tgaaataaat aaccagtatt taagtaaatg tataacgaat gaataaatac atgcataata     4860

ttttcaaagt tctataccag tacctatttt tactcttaca aaatttcctg taaaaaaata     4920

ctacatttga aattatttca ttggttttag aactggcatt gaaggtaccc agtagactct     4980

taagccttta ctgcttgtct cactagaaac atttatttct gacctaccaa gttttcttca     5040

catcatcaaa tttattcagc ttctcagtgc tgtaccgtat gatggcaaga catacttggt     5100

atttccattt ttgttggtca ttctttattg ctttttactg ctaggaaggt cttgccaggc     5160

ttctatacag ttacaaaaac cattaccaaa ctttatcaag gactttccaa atggagtttt     5220

caaatactat tgaccacatt gctctagtta atgtaaggtc agctctgact ttttgtgttt     5280

gcatttcgga agtgaggtaa cctcattcaa atatatatgc agcactttct gtgtacaaag     5340

tactgttcta aatacaaaag ggaatataaa gatgactttc aaggaacata taatgtagtc     5400

agaaagatga gaggattagt tatacaattt aaggaaggga ggataacttt gggaaggttt     5460

tgtggaggat atgtgtttag agatgcgagc tggggattca acaggtaaga gggagagaga     5520

tcacaatttc caactgggta aacagcttga aaaaagaaac agaagcctgg gcacaaatga     5580

aaattccata ttaattggaa gttaagattc atatagagac aatgaaaggt taggttagaa     5640

caataaactg agaagtacga atgtggactt caggaggcta ggggaaatta cgaagtcata     5700

aaaagttcac agagatactt gagtacaaaa gatacattat taaaatttct gcagaagttt     5760

catcttattt gtgtgtgatg gtttggaata taacaagcca gttaggcgta taagcttata     5820

gtggctaata tgaggatgaa atccgtactc ttgtgacaca agtcttcagc ggagatgggg     5880

gatgataggc ccaaatagaa agaaaagtgg cagacattaa gctttgacta acagacaaca     5940

taactgagag acatggtgtg ttgggtggaa gggatcctgt agtagatact tgcttgcatg     6000

tagatgggta caaagacacc ataaggaaat tctgaatgta atacaaaggc ttatttttcc     6060

tgttgattta tctttttcac acataaaaga tgaagaaaaa aataatctga aatgtaaatc     6120

ctaaagtgat ctgtctagat tcttattttt tgaaaaatgt tcctcactaa aagagttttc     6180

tattcaaata accatttcca gttttctaac tgagacatac atacatatat atatgtataa     6240

aattatatat atatttggac aaagagaata agagaattgc aggtagaaat agtctactgt     6300

gtgtagacaa atccagaaag ttgatttctg ttcctcaaac aatttctgaa atatttatgt     6360

cagaataaat aaaagaattg ttattgttgg acaatgaaac atacctggac cctttgagtg     6420

tgtgaatagt aaaggctgtg ataactgaaa tgcagctaag caaaaagggc taattagaag     6480

acttttgaga catgatttac ctaaatggaa atagtttggt tttcaatcct tcactgtaat     6540

aacaattatt tgcatctatt aagtgtttgt agtcactttg tataataaag ttttatggct     6600

tgtgattata atggcttctg ttattctgct actgcctcat tgttttgagg aacatttgta     6660

attttgtggc aaaggtgtct caatttttca gtgttcttta ctctcatgat ccttagaaca     6720

aaaaaaatac cagtaacttg ttataaataa agagtcacat tctcttaaa                 6769


<210>  30
<211>  3310
<212>  DNA
<213>  Homo sapiens

<400>  30
agagccactc catctgaggg tggctgcgtg tccacatacg aggggacagg gctgaggatg       60

aggagaaccc tggggaccca gaagaccgtg ccttgcctgg aagtcctgcc tgtaggcctg      120

aaggacttgc cctaacagag cctcaacaac tacctggtga ttcctacttc agccccttgg      180

tgtgagcagc ttctcaacat gaactacagc ctccacttgg ccttcgtgtg tctgagtctc      240

ttcactgaga ggatgtgcat ccaggggagt cagttcaacg tcgaggtcgg cagaagtgac      300

aagctttccc tgcctggctt tgagaacctc acagcaggat ataacaaatt tctcaggccc      360

aattttggtg gagaacccgt acagatagcg ctgactctgg acattgcaag tatctctagc      420

atttcagaga gtaacatgga ctacacagcc accatatacc tccgacagcg ctggatggac      480

cagcggctgg tgtttgaagg caacaagagc ttcactctgg atgcccgcct cgtggagttc      540

ctctgggtgc cagatactta cattgtggag tccaagaagt ccttcctcca tgaagtcact      600

gtgggaaaca ggctcatccg cctcttctcc aatggcacgg tcctgtatgc cctcagaatc      660

acgacaactg ttgcatgtaa catggatctg tctaaatacc ccatggacac acagacatgc      720

aagttgcagc tggaaagctg gggctatgat ggaaatgatg tggagttcac ctggctgaga      780

gggaacgact ctgtgcgtgg actggaacac ctgcggcttg ctcagtacac catagagcgg      840

tatttcacct tagtcaccag atcgcagcag gagacaggaa attacactag attggtctta      900

cagtttgagc ttcggaggaa tgttctgtat ttcattttgg aaacctacgt tccttccact      960

ttcctggtgg tgttgtcctg ggtttcattt tggatctctc tcgattcagt ccctgcaaga     1020

acctgcattg gagtgacgac cgtgttatca atgaccacac tgatgatcgg gtcccgcact     1080

tctcttccca acaccaactg cttcatcaag gccatcgatg tgtacctggg gatctgcttt     1140

agctttgtgt ttggggcctt gctagaatat gcagttgctc actacagttc cttacagcag     1200

atggcagcca aagatagggg gacaacaaag gaagtagaag aagtcagtat tactaatatc     1260

atcaacagct ccatctccag ctttaaacgg aagatcagct ttgccagcat tgaaatttcc     1320

agcgacaacg ttgactacag tgacttgaca atgaaaacca gcgacaagtt caagtttgtc     1380

ttccgagaaa agatgggcag gattgttgat tatttcacaa ttcaaaaccc cagtaatgtt     1440

gatcactatt ccaaactact gtttcctttg atttttatgc tagccaatgt attttactgg     1500

gcatactaca tgtatttttg agtcaatgtt aaatttcttg catgccatag gtcttcaaca     1560

ggacaagata atgatgtaaa tggtatttta ggccaagtgt gcacccacat ccaatggtgc     1620

tacaagtgac tgaaataata tttgagtctt tctgctcaaa gaatgaagct ccaaccattg     1680

ttctaagctg tgtagaagtc ctagcattat aggatcttgt aatagaaaca tcagtccatt     1740

cctctttcat cttaatcaag gacattccca tggagcccaa gattacaaat gtactcaggg     1800

ctgtttattc ggtggctccc tggtttgcat ttacctcata taaagaatgg gaaggagacc     1860

attgggtaac cctcaagtgt cagaagttgt ttctaaagta actatacatg ttttttacta     1920

aatctctgca gtgcttataa aatacattgt tgcctattta gggagtaaca ttttctagtt     1980

tttgtttctg gttaaaatga aatatgggct tatgtcaatt cattggaagt caatgcacta     2040

actcaatacc aagatgagtt tttaaataat gaatattatt taataccaca acagaattat     2100

ccccaatttc caataagtcc tatcattgaa aattcaaata taagtgaaga aaaaattagt     2160

agatcaacaa tctaaacaaa tccctcggtt ctaagataca atggattccc catactggaa     2220

ggactctgag gctttattcc cccactatgc atatcttatc attttattat tatacacaca     2280

tccatcctaa actatactaa agcccttttc ccatgcatgg atggaaatgg aagatttttt     2340

tttaacttgt tctagaagtc ttaatatggg ctgttgccat gaaggcttgc agaattgagt     2400

ccattttcta gctgccttta ttcacatagt gatggggtac taaaagtact gggttgactc     2460

agagagtcgc tgtcattctg tcattgctgc tactctaaca ctgagcaaca ctctcccagt     2520

ggcagatccc ctgtatcatt ccaagaggag cattcatccc tttgctctaa tgatcaggaa     2580

tgatgcttat tagaaaacaa actgcttgac ccaggaacaa gtggcttagc ttaagtaaac     2640

ttggctttgc tcagatccct gatccttcca gctggtctgc tatgagtggc ttatcccgca     2700

tgagcaggag cgtgctggcc ctgagtactg aactttctga gtaacaatga gatacgttac     2760

agaacctatg ttcaggttgc gggtgagctg ccctctccaa atccagccag agatgcacat     2820

tcctcggcca gtctcagcca acagtaccaa aagtgatttt tgagtgtgcc agggtaaagg     2880

cttccagttc agcctcagtt attttagaca atctcgccat ctttaatttc ttagcttcct     2940

gttctaataa atgcacggct ttacctttcc tgtcagaaat aaaccaaggc tctaaaagat     3000

gatttccctt ctgtaactcc ctagagccac aggttctcat tccttttccc attatacttc     3060

tcacaattca gtttctatga gtttgatcac ctgatttttt taacaaaata tttctaacgg     3120

gaatgggtgg gagtgctggt gaaaagaggt gaaatgtggt tgtatgagcc aatcatattt     3180

gtgatttttt aaaaaaagtt taaaaggaaa tatctgttct gaaaccccac ttaagcattg     3240

tttttatata aaaacaatga taaagatgtg aaactgtgaa ataaatatac catattagct     3300

acccaccaaa                                                            3310


<210>  31
<211>  3488
<212>  DNA
<213>  Homo sapiens

<400>  31
gcaaaaccgt gagctggatt tataatcgcc ctataaagct ccagaggcgg tcaggcacct       60

gcagaggagc cccgccgctc cgccgactag ctgcccccgc gagcaacggc ctcgtgattt      120

ccccgccgat ccggtccccg cctccccact ctgcccccgc ctaccccgga gccgtgcagc      180

cgcctctccg aatctctctc ttctcctggc gctcgcgtgc gagagggaac tagcgagaac      240

gaggaagcag ctggaggtga cgccgggcag attacgcctg tcagggccga gccgagcgga      300

tcgctgggcg ctgtgcagag gaaaggcggg agtgcccggc tcgctgtcgc agagccgagc      360

ctgtttctgc gccggaccag tcgaggactc tggacagtag aggccccggg acgaccgagc      420

tgatggcgtc ttcgacccca tcttcgtccg caacctcctc gaacgcggga gcggacccca      480

ataccactaa cctgcgcccc acaacgtacg atacctggtg cggcgtggcc catggatgca      540

ccagaaaact ggggctcaag atctgcggct tcttgcaaag gaccaacagc ctggaagaga      600

agagtcgcct tgtgagtgcc ttcaaggaga ggcaatcctc caagaacctg ctttcctgtg      660

aaaacagcga ccgggatgcc cgcttccggc gcacagagac tgacttctct aatctgtttg      720

ctagagatct gcttccggct aagaacggtg aggagcaaac cgtgcaattc ctcctggaag      780

tggtggacat actcctcaac tatgtccgca agacatttga tcgctccacc aaggtgctgg      840

actttcatca cccacaccag ttgctggaag gcatggaggg cttcaacttg gagctctctg      900

accaccccga gtccctggag cagatcctgg ttgactgcag agacaccttg aagtatgggg      960

ttcgcacagg tcatcctcga tttttcaacc agctctccac tggattggat attattggcc     1020

tagctggaga atggctgaca tcaacggcca ataccaacat gtttacatat gaaattgcac     1080

cagtgtttgt cctcatggaa caaataacac ttaagaagat gagagagata gttggatggt     1140

caagtaaaga tggtgatggg atattttctc ctgggggcgc catatccaac atgtacagca     1200

tcatggctgc tcgctacaag tacttcccgg aagttaagac aaagggcatg gcggctgtgc     1260

ctaaactggt cctcttcacc tcagaacaga gtcactattc cataaagaaa gctggggctg     1320

cacttggctt tggaactgac aatgtgattt tgataaagtg caatgaaagg gggaaaataa     1380

ttccagctga ttttgaggca aaaattcttg aagccaaaca gaagggatat gttccctttt     1440

atgtcaatgc aactgctggc acgactgttt atggagcttt tgatccgata caagagattg     1500

cagatatatg tgagaaatat aacctttggt tgcatgtcga tgctgcctgg ggaggtgggc     1560

tgctcatgtc caggaagcac cgccataaac tcaacggcat agaaagggcc aactcagtca     1620

cctggaaccc tcacaagatg atgggcgtgc tgttgcagtg ctctgccatt ctcgtcaagg     1680

aaaagggtat actccaagga tgcaaccaga tgtgtgcagg atacctcttc cagccagaca     1740

agcagtatga tgtctcctac gacaccgggg acaaggcaat tcagtgtggc cgccacgtgg     1800

atatcttcaa gttctggctg atgtggaaag caaagggcac agtgggattt gaaaaccaga     1860

tcaacaaatg cctggaactg gctgaatacc tctatgccaa gattaaaaac agagaagaat     1920

ttgagatggt tttcaatggc gagcctgagc acacaaacgt ctgtttttgg tatattccac     1980

aaagcctcag gggtgtgcca gacagccctc aacgacggga aaagctacac aaggtggctc     2040

caaaaatcaa agccctgatg atggagtcag gtacgaccat ggttggctac cagccccaag     2100

gggacaaggc caacttcttc cggatggtca tctccaaccc agccgctacc cagtctgaca     2160

ttgacttcct cattgaggag atagaaagac tgggccagga tctgtaatca tccttcgcag     2220

aacatgagtt tatgggaatg ccttttccct ctggcactcc agaacaaacc tctatatgtt     2280

gctgaaacac acaggccatt tcattgaggg aaaacataat atcttgaaga atattgttaa     2340

aaccttactt aaagcttgtt tgttctagtt agcaggaaat agtgttcttt ttaaaaagtt     2400

gcacattagg aacagagtat atatgtacag ttatacatac ctctctctat atatacatgt     2460

atagtgagtg tggcttagta atagatcacg gcatgtttcc cgctccaaga gaattcactt     2520

taccttcagc agttaccgag gagctaaaca tgctgccaac cagcttgtcc aacaactcca     2580

ggaaaactgt ttttcaaaac gccatgtcct aggggccaag ggaaatgctg ttggtgagaa     2640

tcgacctcac tgtcagcgtt tctccacctg aagtgatgat ggatgagaaa aaacaccacc     2700

aaatgacaag tcacaccctc cccattagta tcctgttagg ggaaaatagt agcagagtca     2760

ttgttacagg tgtactatgg ctgtattttt agagattaat ttgtgtagat tgtgtaaatt     2820

cctgttgtct gaccttggtg gtgggagggg gagactatgt gtcatgattt caatgattgt     2880

ttaattgtag gtcaatgaaa tatttgctta tttatattca gagatgtacc atgttaaaga     2940

ggcgtcttgt attttcttcc catttgtaat gtatcttatt tatatatgaa gtaagttctg     3000

aaaactgttt atggtatttt cgtgcatttg tgagccaaag agaaaagatt aaaattagtg     3060

agatttgtat ttatattaga gtgcccttaa aataatgatt taagcatttt actgtctgta     3120

agagaattct aagattgtac ataaagtcat atatatggaa atcctgttac ttaaatagca     3180

tctgctcttc tcttacgctc tctgtctggc tgtacgtctg gtgttctcaa tgcttttcta     3240

gcaactgttg gataataact agatctcctg taattttgta gtagttgatg accaatctct     3300

gtgactcgct tagctgaaac ctaaggcaac atttccgaag accttctgaa gatctcagat     3360

aaagtgacca ggctcacaac tgtttttgaa gaagggaaat tcacactgtg cgttttagag     3420

tatgcaagaa gaatataaat aaataaaaat attctccatg gagaatttga acaaaaaaaa     3480

aaaaaaaa                                                              3488


<210>  32
<211>  5069
<212>  DNA
<213>  Homo sapiens

<400>  32
gaggcggagg cggccccggg ctcgggcggc tgggatggag cagaagagcg cggagcaccg       60

gagggcacgc agctgacgga gctgcgctgc gttcgcctcg tttgcctcgc gccctccact      120

ggagctgttc gcgcctcccg gctcccaccg cagcccaccc ggcagaggag tcgctaccag      180

cgcccagtgc gctctgtcag tccgcaaact ccttgccgcc cgccccgggc tgggcaccaa      240

ataccaggct accatggtct acaagactct cttcgctctt tgcatcttaa ctgcaggatg      300

gagggtacag agtctgccta catcagctcc tttgtctgtt tctcttccga caaacattgt      360

accaccgacc accatctgga ctagctctcc acaaaacact gatgcagaca ctgcctcccc      420

atccaacggc actcacaaca actcggtgct cccagttaca gcatcagccc caacatctct      480

gcttcctaag aacatttcca tagagtccag agaagaggag atcaccagcc caggttcgaa      540

ttgggaaggc acaaacacag acccctcacc ttctgggttc tcgtcaacaa gcggtggagt      600

ccacttaaca accacgttgg aggaacacag ctcgggcact cctgaagcag gcgtggcagc      660

tacactgtcg cagtccgctg ctgagcctcc cacactcatc tcccctcaag ctccagcctc      720

atcaccctca tccctatcaa cctcaccacc tgaggtcttt tctgcctccg ttactaccaa      780

ccatagctcc actgtgacca gcacccaacc cactggagct ccaactgcac cagagtcccc      840

gacagaggag tccagctctg accacacacc cacttcacat gccacagctg agccagtacc      900

ccaggagaaa acacccccaa caactgtgtc aggcaaagtg atgtgtgagc tcatagacat      960

ggagaccacc accacctttc ccagggtgat catgcaggaa gtagaacatg cattaagttc     1020

aggcagcatc gccgccatta ccgtgacagt cattgccgtg gtgctgctgg tgtttggagt     1080

tgcagcctac ctaaaaatca ggcattcctc ctatggaaga cttttggacg accatgacta     1140

cgggtcctgg ggaaactaca acaaccctct gtacgatgac tcctaacaat ggaatatggc     1200

ctgggatgag gattaactgt tctttattta taagtgctta tccagtagaa ttaataagta     1260

cctgatgcgc attgaacgac aatcttaagc cctgttttgt tggtatggtt gtttttgttt     1320

tcctccctct cctctggctg ctacaacttc ccctttctgg tacaagaaga accattcttt     1380

aaaggtgagt ggaggctgat ttgcagctga agtgggccag ccttgcacca gccaggccag     1440

accaccatgg tgaaggcttc tttccccact gcaggaccca ctttgagaag gaccgaggag     1500

gaggatttgg gttgttttgt taggggttac tttcagggga acatttcatt tgtgttattt     1560

cttaaacttc tatttaggaa attacattaa gtattaatga ggggaaagga aatgagctct     1620

acgaggattt caccctgcat gggagagagc agggttttct cagattcctt tttaatctct     1680

atttatctgg ttgtttctga caggatgctg cctgcttggc tctacaagct ggaaagcagc     1740

ttcttagctg cctaattaat gaaagatgaa aataggaagt gccctggagg gggccagcag     1800

gtcacggggc agaatctctc aggttgctgt gggatctcag tgtgccccta cctgttctcc     1860

cctccaggcc acctgtctct gtaaaggatg tctgctctgt tcaaaaggca gctgggatcc     1920

cagcccacaa gtgatcagca gagttgcatt tccaaagaaa aaggctatga gatgagctga     1980

gttatagaga gaaagggaga ggcatgtacg gtgtggggaa gtggaagaga agctggcggg     2040

ggagaaggag gctaacctgc actgagtact tcattaggac aagtgagaat cagctattga     2100

taatggccag agatatccac agcttggagg agcccagaga ccgtttgctt tatacccaca     2160

cagcaactgg tccactgctt tactgtctgt tggataatgg ctgtaaaatg tttaaaaaca     2220

aaacaaaaca aaaaagaggc actagtctat ctgcaattac tcaacgaggc attttcatag     2280

gaaacagact atgattaatc catttattct tcccacacac ttaccttact aagtctttgc     2340

tttaataaat gagcaaccct gggtatagtc ttaaaattct gcacaataaa ttttgagaaa     2400

gaattgttcc tctttgtagg tatctgtgta ttgcaatcat tctcaaccag gaggtgattt     2460

tgccccctga ctccacccca gggacattca aaaatgtctg gtgacagttt tcattgtcat     2520

gacttggggg tgctactaga agccaggaat gctgccaaac attctaccat gcacagcaca     2580

acctacaaca gcaaagaatc atccacccca aaatatcagt agtgccgaga ttgagaaacc     2640

ctgatttatc acaatgccca ctgtgacaga acaagacact cacagattag tgatacgttt     2700

tatttttaac aaaatgaaat gatgtgttaa gtttttattt ccaaagtgtt tagtttattg     2760

gctgatgggt tgttcttggt atgcatggtg acctttttat ttctgtgtgc ttcctagaga     2820

gctttatttc atggcgacaa ctctgtcttc ttgtaacagc tgatattagc aagcagcatc     2880

ttatgtcctg atttcatata gtagaaaaca aacattgggt ccgacttcaa aatgtgttgt     2940

attgtcctac agtgtcataa agaacctgaa aatgaacttt tgtttctaaa gttggacctt     3000

gctgccatga ctgtttagtt tacagaaact tgaccccggc tcatcctgtc tctggctgtg     3060

gcccggcaaa gcactgaaaa cccctctggt ctcagagaca gtaggggcag tgccactttc     3120

tacaacctgc caacccacac actggagtaa ttctgaaaaa aattattcct aaactctcta     3180

agtgtggacg gagaatgagc aagccccaga agtattttac aaccagagtg ggtaatgagg     3240

agggggctta ctggaatcgt catatctctg aatattgaaa acaacaacta aaaaagtgga     3300

ccttctcaga aaaaaagggc agcaaatgac caagggcgcc ccttctggcc gtgcttggct     3360

tgagtaactg tctctctttc cccaccccca tcacagggct ttcagtttgg caaaggaaaa     3420

gcagataaaa acagaacatt ccatatgttt ctttctccat cggccaaaaa cattttgaca     3480

caatgtttgt gaaacacctt tggagaggtg cacttctgaa tgctgcctct gccgtaaatc     3540

ctggggcaag ggatcagcct cttcccagga accatcgcct tctataaacc gtgaactcaa     3600

gcaggcattt tttttttctt accgaaaggc tgctattgtg caagggcaca taatgggtct     3660

gttgctctta ttggcttcca aatgtgcatg gcaaagagag agatgtgggc ctagagcaga     3720

tatattcagc aaggtgacag cttcccataa caattctaac acttcttatc ttatgtgaga     3780

ataaaatatt taagggttga accttatttt gccaaatgta tcttttctgc ttttgaattg     3840

ggcagaagat tttagcaact atattctaca aatgttactt ataacacaca cacacacatc     3900

tgaaatatat gccgaaaatt gacgtctttg acctcaggga gagcacctgt ccaggtctgc     3960

ctaaaggaaa tggctccagt gggtctaaac aaccacatcc tatccatgga taggtctagt     4020

cataacactt tagagagaat gtcagagcag gagggaggca agccgcctct tctcggccat     4080

cgactgcaga tgatgaaaga gcgggattca actttgtttt cttttcctgt ggccccagtg     4140

aaacctcctg ccctccctgc acgtctgtgt cttcatttct aaaatggggg tgatgctttc     4200

atattgacct caccccatac tacctcacag atgtgttgtg aggattaata aaattatgtc     4260

tatggtattt tcagtttctg gagaaaaata cttatagaca gtttaactat tacatagata     4320

tataagtgat ctcagtttct tgtttgctgt gatactaatg tgttgtttta acttattcca     4380

taaaatgaca gttgtgtcct agccacatca gacagctatc taagctctgg actacccctt     4440

tgtgcagctg aatcactgca gggttgacca tgcctggtgc cacagccatg gtttccattt     4500

ctagatgaaa ggatggccta ggacataggt ctcaaagact cttggatcag aatcaggaga     4560

ttagggaaaa caggatggat acctgagcac taacagcagt agacgtagac ctctgtcctt     4620

taccatctga ggtcttctgg attctttgtg gggttaattt tgatttgatg tcatctgttt     4680

gcccttcatc ttgcttgcaa gtgtgcatgg ttcaatccct cacatccagg aaatgaattt     4740

tgcaattggg ccagatgcta atttgcacgt tgattcacct tctttgcctt taagcctttt     4800

ttttcttttt tttttttttg gcaaatgaat gtaccatttc aactttgatt ttaatagtgc     4860

tagttgatat tggtaataat gctaaccaag agatcaatgc cagatttttc tcttggggta     4920

agttagctga agtcatttaa agatggaaag gtgggaaaat tctttgatat ttgatgtcat     4980

tgtatccaca tttgttgtaa gacatattgc ataccaatta taattatatc aattaaagtt     5040

gataaaagct tccaaaaaaa aaaaaaaaa                                       5069


<210>  33
<211>  9112
<212>  DNA
<213>  Homo sapiens

<400>  33
gaagagttga ttgagaagtg cctcttggtt aaggattaac cacagggaaa aatccagcag       60

aaacagaaga actgtgggtt tcttacccca gccctcaagg aagctatgcc gtgaaagggg      120

tactgataca ctgacataca gcaagttgga cggggcatca gttcttcatt tgtggagtgg      180

agaaaagaag aggaaatctc tcatttgggg catttgaagg atggcttccc tgtttcatca      240

gcttcagatc ctggtctgga aaaattggct aggtgtaaaa aggcagccgc tttggacact      300

tgtcttgatc ttatggccag tcattatttt cataattttg gctattactc ggaccaaatt      360

tcctccaact gcaaaaccaa cttgttacct cgcacctcga aaccttccta gtactggatt      420

ctttccattc ctgcagaccc tactctgtga cacagactct aaatgcaaag acacacccta      480

tggcccacaa gatctgcttc gtaggaaagg aattgatgat gcactattta aagacagtga      540

gattctgaga aagtcatcca acctggataa ggacagcagt ttatcattcc agagcaccca      600

agttccagaa agaaggcatg catcactagc cacagtattt cccagtccaa gttctgattt      660

ggaaatcccc ggaacatata ctttcaatgg cagtcaagtg ctcgcacgaa ttcttggctt      720

ggaaaagctg ttaaagcaaa attcaacttc agaagatata cgaagagaac tatgtgacag      780

ctattcagga tacattgtgg atgatgcctt ctcttggacc tttctaggaa gaaatgtttt      840

taacaaattt tgcctttcta acatgaccct tttagagtct tctctccaag aactaaacaa      900

acagttctcc cagctatcca gtgaccccaa caatcagaag atagtgtttc aggaaatagt      960

cagaatgctg tctttcttct cacaagtgca agagcagaaa gctgtgtggc agcttctgtc     1020

tagttttcca aatgtgtttc agaatgacac atcactaagc aatctatttg atgttcttcg     1080

aaaggcaaac agtgtgctgc tggttgtgca gaaggtttat ccacgttttg caactaacga     1140

aggtttcaga accctccaga agtctgttaa acatctgctg tacactctgg actccccagc     1200

tcaaggtgac tccgataata taacgcatgt gtggaatgag gatgatggac agaccttatc     1260

tccaagcagt ctggctgcac agctcctaat tctggaaaac tttgaagatg ccctcttaaa     1320

tatatcagca aatagtcctt atattcctta cttggcatgt gtgagaaatg tgactgacag     1380

tttggccaga ggttcaccag aaaatctaag actcctgcag tccacaatac gatttaaaaa     1440

atcttttctt cgcaatggtt cctatgaaga ttactttcct ccagttcctg aagtcctaaa     1500

atcaaaactg tctcaacttc gaaacttgac cgaacttctt tgtgaatctg aaactttcag     1560

tttgatagag aagtcatgcc agctctctga tatgagcttt gggagcctgt gtgaagaaag     1620

tgagtttgat ctgcaactcc tcgaagcggc agagctgggc accgaaatag cagccagctt     1680

actgtaccat gacaatgtca tatctaaaaa agtgagagat ttgctgactg gagatccaag     1740

caaaattaat ttaaatatgg atcagtttct agaacaggca ctgcaaatga attacttgga     1800

aaatatcact cagttaatac cgatcataga agccatgctg catgtcaata acagtgcaga     1860

tgcttctgaa aagccaggtc agttactaga aatgtttaaa aatgttgaag agctgaaaga     1920

agatttaagg agaacaacag gaatgtccaa caggactatt gacaagttgc tggccattcc     1980

catccctgat aatagagctg agattatttc tcaggtgttc tggctgcatt cctgtgatac     2040

taatatcacc actcccaaac tagaagatgc aatgaaagaa ttctgcaacc tgtctctttc     2100

agagagatcc cggcagtctt acctcatcgg actcaccctt ctgcactact taaacattta     2160

caacttcaca tacaaggtgt ttttcccgag gaaagatcaa aagccagtag aaaagatgat     2220

ggagctcttc ataagactaa aagagattct caatcagatg gcttctggca cacatccgct     2280

gctagacaaa atgagatccc tgaagcaaat gcatctgccc agaagtgttc cattaacaca     2340

ggcaatgtac agaagcaacc gaatgaacac accacaagga tcatttagca ccatctccca     2400

agcattatgt tctcaaggaa ttaccactga atatttaact gccatgctgc cctcttccca     2460

gaggccaaaa ggcaaccaca ccaaggattt tttgacttat aaattaacta aagagcaaat     2520

tgcttcaaaa tatggaattc ccataaattc cacaccattt tgcttctccc tttataaaga     2580

catcattaac atgcccgctg gacctgtgat ttgggctttc ttgaaaccta tgttgttggg     2640

aagaattttg tatgcaccat ataacccagt cacaaaggca ataatggaaa agtccaatgt     2700

aactctgaga cagctggcgg aattaagaga aaaatctcaa gagtggatgg ataagtcgcc     2760

acttttcatg aattccttcc atctgttaaa ccaggcaatt ccaatgctcc agaatactct     2820

aaggaaccct tttgtgcaag tttttgtaaa gttctccgtg ggactcgatg ctgttgaact     2880

attgaaacag atagatgaac tcgatattct aagactgaaa ttagagaaca acattgacat     2940

catcgatcag cttaacacac tatcttccct gacagtaaat atttcctctt gtgtattata     3000

tgaccgtatt caggcagcaa aaaccataga tgaaatggag agagaggcta aaaggctcta     3060

caaaagcaac gaactctttg gaagtgttat ttttaagctt ccttctaaca gaagctggca     3120

cagaggctat gactctggaa atgtctttct tcctcctgtc ataaaatata ccatccggat     3180

gagtctcaag accgcacaga ccacaagaag cctaagaacc aagatttggg ctccagggcc     3240

acacaattct ccatcacaca accagatcta tggcagggct tttatttatt tacaggatag     3300

tattgaaaga gcaatcattg aattgcaaac tggaaggaac tcccaggaaa tagcagtcca     3360

ggttcaagca attccttatc cctgcttcat gaaagacaac ttcctaacca gtgtctctta     3420

ttctcttcca attgtgctta tggttgcctg ggttgtattt atagctgcct ttgtaaaaaa     3480

gcttgtctat gagaaagacc tccggcttca tgagtacatg aagatgatgg gtgtgaactc     3540

ctgcagccat ttctttgcct ggcttataga gagtgttgga tttttactgg ttaccatcgt     3600

gatcctcatc attatactca agtttggcaa tattcttcct aaaacaaatg ggttcatttt     3660

gttcctgtat ttttcggact acagcttctc ggttattgcc atgagctatc ttatcagtgt     3720

cttcttcaac aacaccaaca ttgcagctct gatcggaagc ctcatctaca tcattgcctt     3780

ctttccattt attgttctgg ttacagtgga gaatgagttg agctatgtat tgaaagtgtt     3840

catgagcctg ctgtccccaa cagcattcag ctatgcaagc caatacattg cacgatacga     3900

agaacagggc attggtcttc agtgggaaaa tatgtacacc tccccggttc aggatgacac     3960

cacctcattt ggctggctgt gctgtctaat cctagctgac tctttcattt atttccttat     4020

tgcttggtat gtcaggaatg tcttcccagg gacatacggt atggcagctc cctggtattt     4080

tccaattctt ccttcctatt ggaaggagcg atttgggtgt gcagaggtga agcctgagaa     4140

gagcaatggc ctcatgttta ctaacatcat gatgcagaac accaacccat ctgccagtcc     4200

tgaatacatg ttttcctcta acatcgagcc tgaacctaaa gatctcacag tcggggttgc     4260

cctgcatggg gtcacaaaga tctatggctc aaaagttgct gttgataacc tcaatctgaa     4320

cttttatgaa gggcatatta cttcattgct ggggcccaat ggagctggga aaactactac     4380

catttccatg ttaactgggc tgtttggggc ctcagcaggc accatttttg tatatggaaa     4440

agatatcaaa acagacctac acacggtacg gaagaacatg ggagtctgta tgcagcacga     4500

cgtcttgttc agttacctca ctactaagga gcaccttctc ctatatggtt ccatcaaagt     4560

tcctcactgg actaaaaagc agctccacga ggaagtaaaa aggactttaa aagatactgg     4620

actatatagc catcgtcata agagagttgg aacactgtca ggaggcatga agaggaagtt     4680

atctatatcc atagctctca ttggtggatc aagggtagta attttggatg aaccatctac     4740

tggagttgac ccatgttctc gccgaagtat atgggatgtt atatccaaga acaaaactgc     4800

cagaacaatc attctgtcaa cgcaccactt ggacgaggct gaagtgctga gtgaccgcat     4860

cgccttcctg gagcagggtg ggcttaggtg ctgtgggtcc ccattttacc tcaaggaagc     4920

ctttggcgat gggtatcacc tcacgcttac caagaagaag agtccaaatt taaatgcaaa     4980

tgcagtatgt gacaccatgg ccgtgacagc aatgatccaa tcacatctcc ccgaagccta     5040

cctcaaggag gatattgggg gagagcttgt ttatgtactt cctccattca gcaccaaagt     5100

ctcaggggcc tacctgtcac tcctacgggc actcgacaat ggcatgggtg acctcaacat     5160

cgggtgctac ggcatttcag ataccaccgt ggaggaggtc tttctgaact tgaccaaaga     5220

gtcacaaaaa aatagtgcta tgagtcttga gcacttaaca caaaagaaaa ttgggaattc     5280

caatgccaat ggcatctcaa ctcctgacga tttatctgtg agcagcagca atttcacaga     5340

cagagatgac aaaatcctga caagaggaga gaggctggat ggctttggac tgttgctgaa     5400

gaagatcatg gctatactca tcaagaggtt ccaccacacc cgcaggaact ggaaaggtct     5460

cattgctcag gttatcctcc ccatcgtctt tgttaccact gccatgggcc ttggcacact     5520

gagaaattcc agcaacagtt atccagagat tcagatctcc ccctctcttt atggtacctc     5580

cgaacagaca gccttctatg ctaattatca cccgagcacg gaagcacttg tctcagcaat     5640

gtgggacttc cctggaattg acaacatgtg tctgaacacc agtgatctac agtgtttaaa     5700

caaagacagt ctggaaaaat ggaacaccag tggagaaccc atcactaatt ttggtgtttg     5760

ctcctgctca gaaaatgtcc aggaatgtcc taaatttaac tattccccac cgcacagaag     5820

aacttactca tcccaggtaa tttataacct cactgggcaa cgagtggaaa attatcttat     5880

atcaactgca aatgagtttg tccaaaaaag atatggaggt tggagttttg ggctgccttt     5940

gacaaaagac cttcgttttg atataacagg agtccctgcc aatagaacac ttgccaaggt     6000

atggtatgat ccagaaggct atcactccct tccagcttac ctcaacagcc tgaataattt     6060

ccttctgcga gttaacatgt caaaatacga tgctgcccga catggcatca tcatgtatag     6120

ccatccttat ccaggagtgc aagaccaaga acaagccaca atcagcagtt taatcgatat     6180

tttagtggca ctgtctatct tgatgggcta ctctgtcacc accgccagct ttgtcaccta     6240

tgttgtaagg gaacatcaaa ccaaagccaa acagttgcag cacatttcag gcattggcgt     6300

gacatgctac tgggtaacaa acttcattta tgacatggtt ttctacttgg tgcctgtagc     6360

gttttcaatt ggtatcattg cgattttcaa attacctgca ttctacagtg aaaacaacct     6420

aggcgctgta tctctcctac ttctcctgtt tgggtatgca acattttcct ggatgtactt     6480

gctggctggg ctcttccatg aaacaggaat ggccttcatc acttacgtct gtgtcaactt     6540

gttttttggc attaattcca ttgtttccct gtcagtggta tactttcttt ccaaggaaaa     6600

gcctaatgat ccgactttag aacttatttc tgaaaccctc aagcgcattt tcctgatttt     6660

cccacaattc tgttttggct acggtttgat tgaactttct caacaacagt cggtcctaga     6720

cttcttaaaa gcatatggag tggaataccc aaatgaaacc tttgagatga ataaactagg     6780

tgcaatgttt gtggctttgg tttctcaggg caccatgttt ttttccttgc gactcttaat     6840

caacgaatcc ctgataaaga aactcaggct tttcttcaga aaatttaatt cttcacatgt     6900

aagggagaca atagatgagg atgaagatgt gcgggctgag agattaagag ttgagagtgg     6960

tgcagctgaa tttgacttgg tccaacttta ttgtctcaca aagacctacc aacttatcca     7020

caaaaagatt atagctgtaa acaacatcag cattgggata cctgctggag agtgttttgg     7080

gcttcttgga gtgaatggag caggaaagac cactatattc aagatgctga caggagacat     7140

cattccttca agtggaaaca ttctgatcag aaataagacc ggatctctgg gtcacgttga     7200

ttctcacagc tcattagttg gctactgtcc tcaggaagat gccttagatg acctggtaac     7260

tgtggaagaa catttgtatt tctatgccag ggtacatgga attccagaaa aggatattaa     7320

agaaactgtt cataaactcc ttaggagact tcacctgatg cccttcaagg acagagctac     7380

ctctatgtgc agttatggca caaaaagaaa attatccact gcactggcct tgatagggaa     7440

accttccatt ctactgctgg atgagccgag ctctggcatg gatccgaagt cgaaacggca     7500

cctctggaag atcatttcag aagaagtaca gaacaaatgt tccgtcatcc tcacatctca     7560

cagcatggaa gaatgtgaag ctctctgtac caggttggcc attatggtga atggaaagtt     7620

tcaatgtatt ggatctttgc agcacataaa gagcaggttt ggacgaggat ttactgtcaa     7680

agttcacttg aagaataaca aagtgaccat ggagaccctc acaaagttca tgcagctgca     7740

ctttccaaaa acatacttaa aagatcagca cctcagcatg ctagagtatc atgtaccagt     7800

cacagcagga ggagtcgcaa acatttttga tctgctggaa accaacaaga ctgctttaaa     7860

tattacaaat ttcttagtga gtcagaccac tctggaagag gttttcatca actttgccaa     7920

agaccagaag tcctatgaaa ctgctgatac cagcagccaa ggttccacta taagtgttga     7980

ctcacaagat gaccagatgg agtcttaaca cttccagcaa actcaatctc agcgtgtgac     8040

caatggcttc attttgaaga aaagccacag aagatacact tccgcaagat atcttcattt     8100

taaagtaaag taatatactg tatggaaagt tacaactgtg ttagactaac aagtaattat     8160

aaaaggaaat ttttccttct aaggtcagtg agtgttgttg ctactgaaat gaattcctgt     8220

atactcaaca ctgtgagcat gctaatgtat atgctggtga ttcttatgca aaggtgaagc     8280

cacctcaaga tgaatatctt aatttattac tttcaataaa aagacagttt aaaaggcatg     8340

gattttggta gttgaaatat aagagtggag aagaaaagtc agatggtttg tggcaggtgc     8400

caccgggcaa gcagacaaca taatttattt ccagaaaaca acagaatgaa catcatcatg     8460

aatacatgaa tcggctgtga tgtgtgaact gctaagggcc aaatgaacgt ttgcagagca     8520

gtgggcacaa tgtttacaat gtatgtgtat gtcactttcg gtacctgtga atgcatgggg     8580

acgtgctgaa cccgaaaaaa agtgcctttc cataaggact gcaatagaga gggcaattta     8640

ccctggtggt acacggaacc tagattcact cctgccatgc cttgccaata gtaagctgca     8700

gggtggaaca agaaatcact tgctctgggg ggaagggagg ggggaatggg tgtgtcagct     8760

gggtagatac aaaccctgaa aagagaatcc atgtgctact ggcaggcaac attttttaaa     8820

gctctttcag aaaccctcat atttggggtt tcttttcagg aaacattcct gtggagggaa     8880

aacgaatatg aagataattt tcagctaatt atctgggtga cccagaatcg tgtatatggc     8940

tataggatag acttcttaat aatggcaagt gacgtggccc tggggaaagg tgctttatgt     9000

accgtgtgtg cgtgtatgtg tgtgtatcta tacaagtttg tcagctttgg catgactgtt     9060

tgtctcgaaa accaataaac tcaaagttta gaaaaactca aaaaaaaaaa aa             9112


<210>  34
<211>  2206
<212>  DNA
<213>  Homo sapiens

<400>  34
actatattca caggcttgga gccagtgcca ttcacacttc cccctcttct gcagcagacg       60

gactgagttc ctctaatccc tgtgttcctt ctcccccatc tttctaaaac ccttctctga      120

gagaggaata actatagctt cagggataat atagctttaa ggaaactttt ggcagatgtg      180

gacgtcgtaa catctgggca gtgttaacag aatcccggag gccgggacag accaggagcc      240

actcgttcta ggaatgttaa agtagaaggt tttttccaat tgatgagagg agcagagagg      300

aaggagaaag aggaggagag agaaaaaggg cacaaaatac cataaaacag atcccatatt      360

tctgcttccc ctcactttta gaagttaatt gatggctgac ttctgaaagt cactttcctt      420

tgccctggta cttcaggcca tatacatctt ttcttgtctc cataatcctc cctttcaagg      480

atggccagtc agctaactca aagaggagct ctctttctgc tgttcttcct aactccggca      540

gtgacaccaa catggtatgc aggttctggc tactatccgg atgaaagcta caatgaagta      600

tatgcagagg aggtcccaca ggctcctgcc ctggactacc gagtcccccg atggtgttat      660

acattaaata tccaggatgg agaagccaca tgctactcac cgaagggagg aaattatcac      720

agcagcctgg gcacgcgttg tgagctctcc tgtgaccggg gctttcgatt gattggaagg      780

aggtcggtgc aatgcctgcc aagccgtcgt tggtctggaa ctgcctactg caggcagatg      840

agatgccacg cactaccatt catcactagt ggcacttaca cctgcacaaa tggagtgctt      900

cttgactctc gctgtgacta cagctgttcc agtggctacc acctggaagg tgatcgcagc      960

cgaatctgca tggaagatgg gagatggagt ggaggcgagc ctgtatgtgt agacatagat     1020

ccccccaaga tccgctgtcc ccactcacgt gagaagatgg cagagccaga gaaattgact     1080

gctcgagtat actgggaccc accgttggtg aaagattctg ctgatggtac catcaccagg     1140

gtgacacttc ggggccctga gcctggctct cactttcccg aaggagagca tgtgattcgt     1200

tacactgcct atgaccgagc ctacaaccgg gccagctgca agttcattgt gaaagtacaa     1260

gtgagacgct gcccaactct gaaacctccg cagcacggct acctcacctg cacctcagcg     1320

ggggacaact atggtgccac ctgtgaatac cactgtgatg gcggttatga tcgccagggg     1380

acaccctccc gggtctgtca gtccagccgc cagtggtcag gttcaccacc aatctgtgct     1440

cctatgaaga ttaacgtcaa cgtcaactca gctgctggtc tcttggatca attctatgag     1500

aaacagcgac tcctcatcat ctcagctcct gatccttcca accgatatta taaaatgcag     1560

atctctatgc tacagcaatc cacctgtgga ctggatttgc ggcatgtgac catcattgaa     1620

ctggtgggac agccacctca ggaggtgggg cgcatccggg agcaacagct gtcagccaac     1680

atcatcgagg agctcaggca atttcagcgc ctcactcgct cctacttcaa catggtgttg     1740

attgacaagc agggtattga ccgagaccgc tacatggaac ctgtcacccc cgaggaaatc     1800

ttcacattca ttgatgacta cctactgagc aatcaggagt tgacccagcg tcgggagcaa     1860

agggacatat gcgagtgaac ttgagccagg gcatggttaa agtcaaggga aaagctcctc     1920

tagttagctg aaactgggac ctaataaaag gaggaaatgt tttcccacag ttctagggac     1980

aggactctga ggtgggtgag tttgacaaat cctgcagtgt ttccaggcat ccttttagga     2040

ctgtgtaata gtttccctag aagctaggta gggactgagg acaggccttg ggcagtgggt     2100

tgggggtaga agttcttcct ttcctaaccc gggcccctgc ccagctctcc aaagtctttc     2160

agaaaagtaa atcctaaatt cagtgatgaa aaaaaaaaaa aaaaaa                    2206


<210>  35
<211>  3014
<212>  DNA
<213>  Homo sapiens

<400>  35
gagactttaa catcagaaaa aggatggact tgttgcagtt gctgtagcat tcaaagtcaa       60

gttgtgcttt gcgatgctga gtttactgtt ttaaatggac ttcaagcata gccctgaagt      120

gttgtcccgt tgttcccacc tcctagaggg cctgacagaa gaggtacata tgctatgtga      180

tcatttcaaa ccaagcatca gcaacaatta aaaatattca cttggtatct gtagtttaat      240

aatggaccaa catcaacatt tgaataaaac agcagagtca gcatcttcag agaaaaagaa      300

aacaagacgc tgcaatggat tcaagatgtt cttggcagcc ctgtcattca gctatattgc      360

taaagcacta ggtggaatca ttatgaaaat ttccatcact caaatagaaa ggagatttga      420

catatcctct tctcttgctg gtttaattga tggaagcttt gaaattggaa atttgcttgt      480

gattgtattt gtaagttact ttggatctaa actacacaga ccgaagttaa ttggaattgg      540

ttgtctcctt atgggaactg gaagtatttt gacatcttta ccacatttct tcatgggata      600

ttataggtat tctaaagaaa cccatattaa tccatcagaa aattcaacat caagtttatc      660

aacctgttta attaatcaaa ccttatcatt caatggaaca tcacctgaga tagtagaaaa      720

agattgtgta aaggaatctg ggtcacacat gtggatctat gtcttcatgg ggaatatgct      780

tcgtggcata ggggaaaccc ccatagtacc attggggatt tcatacattg atgattttgc      840

aaaagaagga cattcttcct tgtatttagg tagtttgaat gcaataggaa tgattggtcc      900

agtcattggc tttgcactgg gatctctgtt tgctaaaatg tacgtggata ttggatatgt      960

agatctgagc actatcagaa taactcctaa ggactctcgt tgggttggag cttggtggct     1020

tggtttcctt gtgtctggac tattttccat tatttcttcc ataccatttt ttttcttgcc     1080

gaaaaatcca aataaaccac aaaaagaaag aaaaatttca ctatcattgc atgtgctgaa     1140

aacaaatgat gatagaaatc aaacagctaa tttgaccaac caaggaaaaa atgttaccaa     1200

aaatgtgact ggttttttcc agtctttgaa aagcatcctt accaatcccc tgtatgttat     1260

atttctgctt ttgacattgt tacaagtaag cagctttatt ggttctttta cttacgtctt     1320

taaatatatg gagcaacagt acggtcagtc tgcatctcat gctaactttt tgttgggaat     1380

cataaccatt cctacggttg caactggaat gtttttagga ggatttatca ttaaaaaatt     1440

caaattgtct ttagttggaa ttgccaaatt ttcatttctt acttcgatga tatccttctt     1500

gtttcaactt ctatatttcc ctctaatctg cgaaagcaaa tcagttgccg gcctaacctt     1560

gacctatgat ggaaataatt cagtggcatc tcatgtagat gtaccacttt cttattgcaa     1620

ctcagagtgc aattgtgatg aaagtcagtg ggaaccagtc tgtgggaaca atggaataac     1680

ttacctgtca ccttgtctag caggatgcaa atcctcaagt ggtattaaaa agcatacagt     1740

gttttataac tgtagttgtg tggaagtaac tggtctccag aacagaaatt actcagcaca     1800

cttgggtgaa tgcccaagag ataatacttg tacaaggaaa tttttcatct atgttgcaat     1860

tcaagtcata aactctttgt tctctgcaac aggaggtacc acatttatct tgttgactgt     1920

gaagattgtt caacctgaat tgaaagcact tgcaatgggt ttccagtcaa tggttataag     1980

aacactagga ggaattctag ctccaatata ttttggggct ctgattgata aaacatgtat     2040

gaagtggtcc accaacagct gtggagcaca aggagcttgt aggatatata attccgtatt     2100

ttttggaagg gtctacttgg gcttatctat agctttaaga ttcccagcac ttgttttata     2160

tattgttttc atttttgcta tgaagaaaaa atttcaagga aaagatacca aggcatcgga     2220

caatgaaaga aaagtaatgg atgaagcaaa cttagaattc ttaaataatg gtgaacattt     2280

tgtaccttct gctggaacag atagtaaaac atgtaatttg gacatgcaag acaatgctgc     2340

tgccaactaa cattgcattg attcattaag atgttatttt tgaggtgttc ctggtctttc     2400

actgacaatt ccaacattct ttacttacag tggaccaatg gataagtcta tgcatctata     2460

ataaactata aaaaatggga gtacccatgg ttaggatata gctatgcctt tatggttaag     2520

attagaatat atgatccata aaaatttaaa gtgagaggca tggttagtgt gtgatacaat     2580

aaaaagtaat tgtttggtag ttgtaactgc taataaaacc agtgactaga atataaggga     2640

ggtaaaaagg acaagataga ttaatagcct aaataaagag aaaagcctga tgcctttaaa     2700

aaaaatgaaa cactttggat gtattactta ggccaaaatc tggcctggat ttatgctata     2760

atatatattt tcatgttaag ttgtatattt ttcagaaatt ataaatatta ttaatttaaa     2820

atttgaattt gtgtttgact aacaacctcg atggatcttc ttccaacctc ccattaagat     2880

cctgcagaag aaatagaaat attcaaatat tgcaaggtgt aattgtgaga caacttatta     2940

taatacgtgt taagtttcta ctggacccat ggaagtggat taagaaaaac cgactttagc     3000

ttgagaaagc aaaa                                                       3014


<210>  36
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  36
ccagcggctg cggcggcgga gctcctccga ggtccgggtc accagtctct gctcttccca       60

gcctctccgg cgcgctccaa gggcttcccg tcgggaccat gcgcggccgt gagctcccgc      120

tggtcctgct ggcgctggtc ctctgcctgg cgccccgggg gcgagcggtc ccgctgcctg      180

cgggcggagg gaccgtgctg accaagatgt acccgcgcgg caaccactgg gcggtggggc      240

acttaatggg gaaaaagagc acaggggagt cttcttctgt ttctgagaga gggagcctga      300

agcagcagct gagagagtac atcaggtggg aagaagctgc aaggaatttg ctgggtctca      360

tagaagcaaa ggagaacaga aaccaccagc cacctcaacc caaggccctg ggcaatcagc      420

agccttcgtg ggattcagag gatagcagca acttcaaaga tgtaggttca aaaggcaaag      480

ttggtagact ctctgctcca ggttctcaac gtgaaggaag gaacccccag ctgaaccagc      540

aatgataatg atggcctctc tcaaaagaga aaaacaaaac ccctaagaga ctgcgttctg      600

caagcatcag ttctacggat catcaacaag atttccttgt gcaaaatatt tgactattct      660

gtatctttca tccttgacta aattcgtgat tttcaagcag catcttctgg tttaaacttg      720

tttgctgtga acaattgtcg aaaagagtct tccaattaat gcttttttat atctaggcta      780

cctgttggtt agattcaagg ccccgagctg ttaccattca caataaaagc ttaaacacat      840

tgtccaaaaa aaaaaaaaaa aaa                                              863


<210>  37
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  37
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc       60

tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag      120

ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg      180

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc      240

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg      300

gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact      360

tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca      420

ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc      480

acaagtatca ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc      540

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc      600

taataaaaaa catttatttt cattgc                                           626


<210>  38
<211>  2692
<212>  DNA
<213>  Homo sapiens

<400>  38
gtcacggagc gcttaagagg agggtcgggc tcggccgggg agtcccagtg gcggaggcta       60

cgaaacttgg gggagtgcac agaagaactt cgggagcgca cgcgggacca gggaccaggc      120

tgagactcgg ggcgccagtc cgggcagggg cagcgggagc cggccgggta gggtgcagcc      180

tgaggcttgt tcagcagaac aggtgcaagc cacattgttg ccaagacctg cctgaagccg      240

gattctcccc actgcctcct tcaaccccgc ctcttcctcc tcctgtggga ctgctccccc      300

ctcctgtgag gctagataga tgccctgtat ccaagcccaa tatgggacac cagcaccgag      360

tccgggaccc cgtgaccacc tggcaagcga ccccctgacc cctgagttca tcaagcccac      420

catggacctg gccagccccg aggcagcccc cgctgccccc actgccctgc ccagcttcag      480

caccttcatg gacggctaca caggagagtt tgacaccttc ctctaccagc tgccaggaac      540

agtccagcca tgctcctcag cctcctcctc ggcctcctcc acatcctcgt cctcagccac      600

ctcccctgcc tctgcctcct tcaagttcga ggacttccag gtgtacggct gctaccccgg      660

ccccctgagc ggcccagtgg atgaggccct gtcctccagt ggctctgact actatggcag      720

cccctgctcg gccccgtcgc cctccacgcc cagcttccag ccgccccagc tctctccctg      780

ggatggctcc ttcggccact tctcgcccag ccagacttac gaaggcctgc gggcatggac      840

agagcagctg cccaaagcct ctgggccccc acagcctcca gccttctttt ccttcagtcc      900

tcccaccggc cccagcccca gcctggccca gagccccctg aagttgttcc cctcacaggc      960

cacccaccag ctgggggagg gagagagcta ttccatgcct acggccttcc caggtttggc     1020

acccacttct ccacaccttg agggctcggg gatactggat acacccgtga cctcaaccaa     1080

ggcccggagc ggggccccag gtggaagtga aggccgctgt gctgtgtgtg gggacaacgc     1140

ttcatgccag cattatggtg tccgcacatg tgagggctgc aagggcttct tcaagcgcac     1200

agtgcagaaa aacgccaagt acatctgcct ggctaacaag gactgccctg tggacaagag     1260

gcggcgaaac cgctgccagt tctgccgctt ccagaagtgc ctggcggtgg gcatggtgaa     1320

ggaagttgtc cgaacagaca gcctgaaggg gcggcggggc cggctacctt caaaacccaa     1380

gcagccccca gatgcctccc ctgccaatct cctcacttcc ctggtccgtg cacacctgga     1440

ctcagggccc agcactgcca aactggacta ctccaagttc caggagctgg tgctgcccca     1500

ctttgggaag gaagatgctg gggatgtaca gcagttctac gacctgctct ccggttctct     1560

ggaggtcatc cgcaagtggg cggagaagat ccctggcttt gctgagctgt caccggctga     1620

ccaggacctg ttgctggagt cggccttcct ggagctcttc atcctccgcc tggcgtacag     1680

gtctaagcca ggcgagggca agctcatctt ctgctcaggc ctggtgctac accggctgca     1740

gtgtgcccgt ggcttcgggg actggattga cagtatcctg gccttctcaa ggtccctgca     1800

cagcttgctt gtcgatgtcc ctgccttcgc ctgcctctct gcccttgtcc tcatcaccga     1860

ccggcatggg ctgcaggagc cgcggcgggt ggaggagctg cagaaccgca tcgccagctg     1920

cctgaaggag cacgtggcag ctgtggcggg cgagccccag ccagccagct gcctgtcacg     1980

tctgttgggc aaactgcccg agctgcggac cctgtgcacc cagggcctgc agcgcatctt     2040

ctacctcaag ctggaggact tggtgccccc tccacccatc attgacaaga tcttcatgga     2100

cacgctgccc ttctgacccc tgcctgggaa cacgtgtgca catgcgcact ctcatatgcc     2160

accccatgtg cctttagtcc acggaccccc agagcacccc caagcctggg cttgagctgc     2220

agaatgactc caccttctca cctgctccag gaggtttgca gggagctcaa gcccttgggg     2280

agggggatgc cttcatgggg gtgaccccac gatttgtctt atccccccca gcctggcccc     2340

ggcctttatg ttttttgtaa gataaaccgt ttttaacaca tagcgccgtg ctgtaaataa     2400

gcccagtgct gctgtaaata caggaagaaa gagcttgagg tgggagcggg gctgggagga     2460

agggatgggc cccgccttcc tgggcagcct ttccagcctc ctgctggctc tctcttccta     2520

ccctccttcc acatgtacat aaactgtcac tctaggaaga agacaaatga cagattctga     2580

catttatatt tgtgtatttt cctggattta tagtatgtga cttttctgat taatatattt     2640

aatatattga ataaaaaata gacatgtagt tggaactgaa aaaaaaaaaa aa             2692


<210>  39
<211>  8605
<212>  DNA
<213>  Homo sapiens

<400>  39
aattcgccaa ctgaaaaagt gggaaaggat gtctggaggc gaggcgtccc attacagagg       60

aaggagctcg ctatataagc cagccaaagt tggctgcacc ggccacagcc tgcctactgt      120

cacccgcctc tcccgcgcgc agatacacgc ccccgcctcc gtgggcacaa aggcagcgct      180

gctggggaac tcgggggaac gcgcacgtgg gaaccgccgc agctccacac tccaggtact      240

tcttccaagg acctaggtct ctcgcccatc ggaaagaaaa taattctttc aagaagatca      300

gggacaactg atttgaagtc tactctgtgc ttctaaatcc ccaattctgc tgaaagtgag      360

ataccctaga gccctagagc cccagcagca cccagccaaa cccacctcca ccatgggggc      420

catgactcag ctgttggcag gtgtctttct tgctttcctt gccctcgcta ccgaaggtgg      480

ggtcctcaag aaagtcatcc ggcacaagcg acagagtggg gtgaacgcca ccctgccaga      540

agagaaccag ccagtggtgt ttaaccacgt ttacaacatc aagctgccag tgggatccca      600

gtgttcggtg gatctggagt cagccagtgg ggagaaagac ctggcaccgc cttcagagcc      660

cagcgaaagc tttcaggagc acacagtgga tggggaaaac cagattgtct tcacacatcg      720

catcaacatc ccccgccggg cctgtggctg tgccgcagcc cctgatgtta aggagctgct      780

gagcagactg gaggagctgg agaacctggt gtcttccctg agggagcaat gtactgcagg      840

agcaggctgc tgtctccagc ctgccacagg ccgcttggac accaggccct tctgtagcgg      900

tcggggcaac ttcagcactg aaggatgtgg ctgtgtctgc gaacctggct ggaaaggccc      960

caactgctct gagcccgaat gtccaggcaa ctgtcacctt cgaggccggt gcattgatgg     1020

gcagtgcatc tgtgacgacg gcttcacggg cgaggactgc agccagctgg cttgccccag     1080

cgactgcaat gaccagggca agtgcgtaaa tggagtctgc atctgtttcg aaggctacgc     1140

cggggctgac tgcagccgtg aaatctgccc agtgccctgc agtgaggagc acggcacatg     1200

tgtagatggc ttgtgtgtgt gccacgatgg ctttgcaggc gatgactgca acaagcctct     1260

gtgtctcaac aattgctaca accgtggacg atgcgtggag aatgagtgcg tgtgtgatga     1320

gggtttcacg ggcgaagact gcagtgagct catctgcccc aatgactgct tcgaccgggg     1380

ccgctgcatc aatggcacct gctactgcga agaaggcttc acaggtgaag actgcgggaa     1440

acccacctgc ccacatgcct gccacaccca gggccggtgt gaggaggggc agtgtgtatg     1500

tgatgagggc tttgccggtg tggactgcag cgagaagagg tgtcctgctg actgtcacaa     1560

tcgtggccgc tgtgtagacg ggcggtgtga gtgtgatgat ggtttcactg gagctgactg     1620

tggggagctc aagtgtccca atggctgcag tggccatggc cgctgtgtca atgggcagtg     1680

tgtgtgtgat gagggctata ctggggagga ctgcagccag ctacggtgcc ccaatgactg     1740

tcacagtcgg ggccgctgtg tcgagggcaa atgtgtatgt gagcaaggct tcaagggcta     1800

tgactgcagt gacatgagct gccctaatga ctgtcaccag cacggccgct gtgtgaatgg     1860

catgtgtgtt tgtgatgacg gctacacagg ggaagactgc cgggatcgcc aatgccccag     1920

ggactgcagc aacaggggcc tctgtgtgga cggacagtgc gtctgtgagg acggcttcac     1980

cggccctgac tgtgcagaac tctcctgtcc aaatgactgc catggccagg gtcgctgtgt     2040

gaatgggcag tgcgtgtgcc atgaaggatt tatgggcaaa gactgcaagg agcaaagatg     2100

tcccagtgac tgtcatggcc agggccgctg cgtggacggc cagtgcatct gccacgaggg     2160

cttcacaggc ctggactgtg gccagcactc ctgccccagt gactgcaaca acttaggaca     2220

atgcgtctcg ggccgctgca tctgcaacga gggctacagc ggagaagact gctcagaggt     2280

gtctcctccc aaagacctcg ttgtgacaga agtgacggaa gagacggtca acctggcctg     2340

ggacaatgag atgcgggtca cagagtacct tgtcgtgtac acgcccaccc acgagggtgg     2400

tctggaaatg cagttccgtg tgcctgggga ccagacgtcc accatcatcc aggagctgga     2460

gcctggtgtg gagtacttta tccgtgtatt tgccatcctg gagaacaaga agagcattcc     2520

tgtcagcgcc agggtggcca cgtacttacc tgcacctgaa ggcctgaaat tcaagtccat     2580

caaggagaca tctgtggaag tggagtggga tcctctagac attgcttttg aaacctggga     2640

gatcatcttc cggaatatga ataaagaaga tgagggagag atcaccaaaa gcctgaggag     2700

gccagagacc tcttaccggc aaactggtct agctcctggg caagagtatg agatatctct     2760

gcacatagtg aaaaacaata cccggggccc tggcctgaag agggtgacca ccacacgctt     2820

ggatgccccc agccagatcg aggtgaaaga tgtcacagac accactgcct tgatcacctg     2880

gttcaagccc ctggctgaga tcgatggcat tgagctgacc tacggcatca aagacgtgcc     2940

aggagaccgt accaccatcg atctcacaga ggacgagaac cagtactcca tcgggaacct     3000

gaagcctgac actgagtacg aggtgtccct catctcccgc agaggtgaca tgtcaagcaa     3060

cccagccaaa gagaccttca caacaggcct cgatgctccc aggaatcttc gacgtgtttc     3120

ccagacagat aacagcatca ccctggaatg gaggaatggc aaggcagcta ttgacagtta     3180

cagaattaag tatgccccca tctctggagg ggaccacgct gaggttgatg ttccaaagag     3240

ccaacaagcc acaaccaaaa ccacactcac aggtctgagg ccgggaactg aatatgggat     3300

tggagtttct gctgtgaagg aagacaagga gagcaatcca gcgaccatca acgcagccac     3360

agagttggac acgcccaagg accttcaggt ttctgaaact gcagagacca gcctgaccct     3420

gctctggaag acaccgttgg ccaaatttga ccgctaccgc ctcaattaca gtctccccac     3480

aggccagtgg gtgggagtgc agcttccaag aaacaccact tcctatgtcc tgagaggcct     3540

ggaaccagga caggagtaca atgtcctcct gacagccgag aaaggcagac acaagagcaa     3600

gcccgcacgt gtgaaggcat ccactgaaca agcccctgag ctggaaaacc tcaccgtgac     3660

tgaggttggc tgggatggcc tcagactcaa ctggaccgca gctgaccagg cctatgagca     3720

ctttatcatt caggtgcagg aggccaacaa ggtggaggca gctcggaacc tcaccgtgcc     3780

tggcagcctt cgggctgtgg acataccggg cctcaaggct gctacgcctt atacagtctc     3840

catctatggg gtgatccagg gctatagaac accagtgctc tctgctgagg cctccacagg     3900

ggaaactccc aatttgggag aggtcgtggt ggccgaggtg ggctgggatg ccctcaaact     3960

caactggact gctccagaag gggcctatga gtactttttc attcaggtgc aggaggctga     4020

cacagtagag gcagcccaga acctcaccgt cccaggagga ctgaggtcca cagacctgcc     4080

tgggctcaaa gcagccactc attataccat caccatccgc ggggtcactc aggacttcag     4140

cacaacccct ctctctgttg aagtcttgac agaggaggtt ccagatatgg gaaacctcac     4200

agtgaccgag gttagctggg atgctctcag actgaactgg accacgccag atggaaccta     4260

tgaccagttt actattcagg tccaggaggc tgaccaggtg gaagaggctc acaatctcac     4320

ggttcctggc agcctgcgtt ccatggaaat cccaggcctc agggctggca ctccttacac     4380

agtcaccctg cacggcgagg tcaggggcca cagcactcga ccccttgctg tagaggtcgt     4440

cacagaggat ctcccacagc tgggagattt agccgtgtct gaggttggct gggatggcct     4500

cagactcaac tggaccgcag ctgacaatgc ctatgagcac tttgtcattc aggtgcagga     4560

ggtcaacaaa gtggaggcag cccagaacct cacgttgcct ggcagcctca gggctgtgga     4620

catcccgggc ctcgaggctg ccacgcctta tagagtctcc atctatgggg tgatccgggg     4680

ctatagaaca ccagtactct ctgctgaggc ctccacagcc aaagaacctg aaattggaaa     4740

cttaaatgtt tctgacataa ctcccgagag cttcaatctc tcctggatgg ctaccgatgg     4800

gatcttcgag acctttacca ttgaaattat tgattccaat aggttgctgg agactgtgga     4860

atataatatc tctggtgctg aacgaactgc ccatatctca gggctacccc ctagtactga     4920

ttttattgtc tacctctctg gacttgctcc cagcatccgg accaaaacca tcagtgccac     4980

agccacgaca gaggccctgc cccttctgga aaacctaacc atttccgaca ttaatcccta     5040

cgggttcaca gtttcctgga tggcatcgga gaatgccttt gacagctttc tagtaacggt     5100

ggtggattct gggaagctgc tggaccccca ggaattcaca ctttcaggaa cccagaggaa     5160

gctggagctt agaggcctca taactggcat tggctatgag gttatggtct ctggcttcac     5220

ccaagggcat caaaccaagc ccttgagggc tgagattgtt acagaagccg aaccggaagt     5280

tgacaacctt ctggtttcag atgccacccc agacggtttc cgtctgtcct ggacagctga     5340

tgaaggggtc ttcgacaatt ttgttctcaa aatcagagat accaaaaagc agtctgagcc     5400

actggaaata accctacttg cccccgaacg taccagggac ataacaggtc tcagagaggc     5460

tactgaatac gaaattgaac tctatggaat aagcaaagga aggcgatccc agacagtcag     5520

tgctatagca acaacagcca tgggctcccc aaaggaagtc attttctcag acatcactga     5580

aaattcggct actgtcagct ggagggcacc cacagcccaa gtggagagct tccggattac     5640

ctatgtgccc attacaggag gtacaccctc catggtaact gtggacggaa ccaagactca     5700

gaccaggctg gtgaaactca tacctggcgt ggagtacctt gtcagcatca tcgccatgaa     5760

gggctttgag gaaagtgaac ctgtctcagg gtcattcacc acagctctgg atggcccatc     5820

tggcctggtg acagccaaca tcactgactc agaagccttg gccaggtggc agccagccat     5880

tgccactgtg gacagttatg tcatctccta cacaggcgag aaagtgccag aaattacacg     5940

cacggtgtcc gggaacacag tggagtatgc tctgaccgac ctcgagcctg ccacggaata     6000

cacactgaga atctttgcag agaaagggcc ccagaagagc tcaaccatca ctgccaagtt     6060

cacaacagac ctcgattctc caagagactt gactgctact gaggttcagt cggaaactgc     6120

cctccttacc tggcgacccc cccgggcatc agtcaccggt tacctgctgg tctatgaatc     6180

agtggatggc acagtcaagg aagtcattgt gggtccagat accacctcct acagcctggc     6240

agacctgagc ccatccaccc actacacagc caagatccag gcactcaatg ggcccctgag     6300

gagcaatatg atccagacca tcttcaccac aattggactc ctgtacccct tccccaagga     6360

ctgctcccaa gcaatgctga atggagacac gacctctggc ctctacacca tttatctgaa     6420

tggtgataag gctgaggcgc tggaagtctt ctgtgacatg acctctgatg ggggtggatg     6480

gattgtgttc ctgagacgca aaaacggacg cgagaacttc taccaaaact ggaaggcata     6540

tgctgctgga tttggggacc gcagagaaga attctggctt gggctggaca acctgaacaa     6600

aatcacagcc caggggcagt acgagctccg ggtggacctg cgggaccatg gggagacagc     6660

ctttgctgtc tatgacaagt tcagcgtggg agatgccaag actcgctaca agctgaaggt     6720

ggaggggtac agtgggacag caggtgactc catggcctac cacaatggca gatccttctc     6780

cacctttgac aaggacacag attcagccat caccaactgt gctctgtcct acaaaggggc     6840

tttctggtac aggaactgtc accgtgtcaa cctgatgggg agatatgggg acaataacca     6900

cagtcagggc gttaactggt tccactggaa gggccacgaa cactcaatcc agtttgctga     6960

gatgaagctg agaccaagca acttcagaaa tcttgaaggc aggcgcaaac gggcataaat     7020

tccagggacc actgggtgag agaggaataa ggcccagagc gaggaaagga ttttaccaaa     7080

gcatcaatac aaccagccca accatcggtc cacacctggg catttggtga gagtcaaagc     7140

tgaccatgga tccctggggc caacggcaac agcatgggcc tcacctcctc tgtgatttct     7200

ttctttgcac caaagacatc agtctccaac atgtttctgt tttgttgttt gattcagcaa     7260

aaatctccca gtgacaacat cgcaatagtt ttttacttct cttaggtggc tctgggaatg     7320

ggagaggggt aggatgtaca ggggtagttt gttttagaac cagccgtatt ttacatgaag     7380

ctgtataatt aattgtcatt atttttgtta gcaaagatta aatgtgtcat tggaagccat     7440

cccttttttt acatttcata caacagaaac cagaaaagca atactgtttc cattttaagg     7500

atatgattaa tattattaat ataataatga tgatgatgat gatgaaaact aaggattttt     7560

caagagatct ttctttccaa aacatttctg gacagtacct gattgtattt tttttttaaa     7620

taaaagcaca agtacttttg agtttgttat tttgctttga attgttgagt ctgaatttca     7680

ccaaagccaa tcatttgaac aaagcgggga atgttgggat aggaaaggta agtagggata     7740

gtggtcaagt gggaggggtg gaaaggagac taaagactgg gagagaggga agcacttttt     7800

ttaaataaag ttgaacacac ttgggaaaag cttacaggcc aggcctgtaa tcccaacact     7860

ttgggaggcc aaggtgggag gatagcttaa ccccaggagt ttgagaccag cctgagcaac     7920

atagtgagaa cttgtctcta cagaaaaaaa aaaaaaaaaa aatttaatta ggcaagcgtg     7980

gtagtgcgca cctgtcgtcc cagctactca ggaggctgag gtaggaaaat cactggagcc     8040

caggagttag aggttacagt gagctatgat cacactactg cactccagcc tgggcaacag     8100

agggagaccc tgtctctaaa taaaaaaaga aaagaaaaaa aaagcttaca acttgagatt     8160

cagcatcttg ctcagtattt ccaagactaa tagattatgg tttaaaagat gcttttatac     8220

tcattttcta atgcaactcc tagaaactct atgatatagt tgaggtaagt attgttacca     8280

cacatgggct aagatcccca gaggcagact gcctgagttc aattcttggc tccaccattc     8340

ccaagttccc taacctctct atgcctcagt ttcctcttct gtaaagtagg gacactcata     8400

cttctcattt cagaacattt ttgtgaagaa taaattatgt tatccatttg aggcccttag     8460

aatggtaccc ggtgtatatt aagtgctagt acatgttagc tatcatcatt atcactttat     8520

atgagatgga ctggggttca tagaaaccca atgacttgat tgtggctact actcaataaa     8580

taatagaatt tggatttaaa aaaaa                                           8605


<210>  40
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  40
ctctgggctg ctcgggcgcc accactactg tccccatccc gccccgccag ctgggccaaa       60

gggtgacttg actcacgacg ctgccaccag cccacggctt gcccgaggcg tataaaggct      120

gccagggccg caggctgcca agccctgccc tgcccaaggc gcatagagca tggcccgagg      180

cgctgaggga ggccgtgggg acgcgggttg gggcctgcgt ggcgccctgg cggccgtggc      240

gctgctctcg gcgctcaacg ctgcgggcac ggtgttcgcg ctgtgccagt ggcgcgggct      300

gagctcggcg ctgcgggctt tggaggcgca gcggggccgg gagcagcgcg aggacagtgc      360

cctgcgctcc ttcctggccg agttgagccg cgcgccgcgc ggggcgtccg caccacccca      420

agacccggcc agctcagctc gcaacaagcg cagccacagc ggcgagcccg cgccgcatat      480

ccgcgccgag agccatgaca tgctgatgat gatgacctac tccatggtgc cgatccgagt      540

gatggtggac ctgtgcaaca gcaccaaggg catctgcctc acaggacctt ctggaccacc      600

aggacctccg ggagccggcg ggttgccagg acacaacgga ttggatggac agcctggtcc      660

tcagggccca aaaggagaaa aaggagcaaa tggaaaaaga ggaaaaatgg ggatacctgg      720

agctgcagga aatccagggg aaaggggaga aaagggagac catggtgaac tgggcctgca      780

gggaaatgag ggcccaccag ggcagaaggg agaaaagggt gacaaaggag atgtgtccaa      840

cgacgtgctc ctggcaggtg ccaaaggtga ccaaggccca cccggtccac ctgggccccc      900

aggccctcca ggtcctccag ggccccctgg aagcagaaga gccaaaggcc ctcggcagcc      960

aagcatgttc aacggccagt gcccaggtga gacttgtgcc ataccaaatg atgatacctt     1020

ggttggaaaa gctgatgaga aagccagtga acaccattcc ccacaagcag aatccatgat     1080

cacttccatt ggaaacccag tgcaagtact gaaagtgaca gagacatttg ggacttggat     1140

aagagagtct gctaacaaga gtgatgaccg gatttgggtg acagagcatt tttcaggcat     1200

catggttaag gaattcaagg atcagccctc acttctgaat ggcagttaca cgttcatcca     1260

ccttccatac tatttccatg gctgtgggca cgttgtttac aacaactctc tctactacca     1320

caaagggggt tctaataccc tagtgagatt tgaatttggc caggaaacat cccaaactct     1380

gaagcttgaa aatgccttgt attttgatcg aaaatacctt tttgcaaatt ccaaaactta     1440

cttcaatcta gctgtagatg aaaagggcct ttggattatc tatgcgtcaa gtgtggacgg     1500

ctcgagcatt cttgtagcac aactggatga gaggacattc tcagtggtgc aacacgtcaa     1560

taccacgtac cctaaatcca aggctggcaa cgccttcatt gcccgaggaa tcctctatgt     1620

cacagacacc aaagatatga gggtcacatt tgcctttgat ttgttaggag ggaaacagat     1680

caatgcaaac tttgatttaa gaacttccca gtctgttctt gccatgttag catacaacat     1740

gagagatcag catttatatt catgggaaga tggccattta atgctttatc ctgtgcagtt     1800

tttgtcaact accttaaatc agtgatgtgc tgcattcggc tcccttcagc aaatttcagg     1860

ggttttctgg gaccagttct cccccaacag gaaacttgtt tttttaacgt cagccagata     1920

tttagaaaat aacctcaaaa gtgtttatat ggtcagtgag ccccgcttag tgaaatagca     1980

acagattgga agttgaaatg gctgagattt ggtgatctcc ccacagctgg ctctgcaagt     2040

tacctctttc tccttgggcc ttagtttccc cattggtaat ctgaattggc taagatgatt     2100

ggggagattt tctgtacctg taggtaattt ggtgattctt ggtggctgct cttctcacaa     2160

cttttatgta tctgcttctg tcgtttagct tttttagcca catgctgacc aaatttacct     2220

ttgagttgat aagtccagtg gcttgagtag tgaatccctc agtgctgact tatatcttgt     2280

tctttgaaaa aatgcattga ctctttaaga catctaaagt atcacattat ccataattta     2340

ttgcttttct ttgcatctgc acctgccacc acagaataac cattaccctc agctgctgat     2400

tgggcagctc tgagattagc aaaagccagg gacagctaca tgttcaggtt tttttttttt     2460

tttttttttc aataagctat tttttttctt ttcttatttt aaatagagag agagtcttgc     2520

tatgtttccc aggctggtct tgaactcctg gggctcaagt gatcctcctg ccttggcctc     2580

ccaaaatgct ggattacagg catgtgtgcc tggcccaggt ttcttaataa aacagaatca     2640

tgatcttcca ggttcccccc agtttctgat catgttgatt tgtagctgtg gatcatgaac     2700

actgaatcct cagatcactc tgacttctta tgcttctcct gtggatccac tatcaaagta     2760

ctaaatgctg tgtaagtaga cgttaatctg gctggaacca tgggaagcac tttgcagtgt     2820

tcagaagaga ggctccattt gtggctatta tgtagaactg ggccagagcc agtccattgc     2880

ctgttttttt aaataaggtt ttactgagca cagccacact catttgttta tgcagtacgg     2940

cctgacattg cttttgctct gcaacagcag agtcgagtca ttgcaacaaa gagcatatgg     3000

ccccacagtg cctaaaatat tgaccagcta cccctttatg gaaaaagatt gctgactcct     3060

gataaagaat ataaagtgag cctgattctt gaaaaaatca gaaccagagc ctgttttgtt     3120

ttgttctaaa ctaagaagcc gcataggatg tgacttgcgt tttgagtaga ggggaaggct     3180

gataacggcg taagatgaag tggccctcca caaaggctgg ttaggggaca gttctttctc     3240

taacatagtt ttaaaggatg tgatctggtc cccttggatg ccaggagaga atccagttga     3300

acttgctcct aaatgctctt aaatatgcat attttctgcc aactcacttc tttaaacatc     3360

tttcagccca gcgctgcggc cccgggaagg gccactgcga atagagagga agctggaaaa     3420

gttcctgggg ctctgcagcc aggaagggga accagggcaa atcttatgta aagatttttc     3480

agcaacttgt cccaatttgt gtgtattctg aaactttctc tttgggacca aattcattct     3540

caatggccct gagttcaata tattattaac agcagtattt taaaacttag ggttgaactg     3600

ggcatggtgg cacataactg caatcccagc tactttggag gcagggatgg gaggatcact     3660

tgaggccagg atctcaggac cagcctagag agatcccatc tctaaaaaat aaaatataag     3720

aaaataaaac ttaggggata tacagattta aatattcaaa tctccctgct cccctgaaag     3780

tccccaggca gctgtcaatg acttgtttgt tgtgttctca atatgatggc tatttgaaac     3840

ttcacctact tttcattaga ttggttgtac catgtcacct tagcttttaa aaatactctt     3900

ttcagattca cgttctctaa caaagagtct catgttcaag atcaatatgt ctaataagtg     3960

ctggtgtcct tttaaagtat ttaaatatat atgttgctgt tgctgaatac aggagaccag     4020

gttaggaata tagtttcata ataatagtac atacaatact aattgtatat aaggtagcaa     4080

ccaaaagagg ttgttaatta gcacatattc cttttagaaa aatgtttcag aaacctcagt     4140

cttgatatct gagctatctg ggctccctta cttgtgagta agggatcatg ctcaccactg     4200

gagaagctta caccgggact ttttttcttt tttctttttt ttttgctatg acagagtaat     4260

gctaacgtaa ggacaactga gtttgatcag tgtttaatcg cagtgggtaa tcttatctga     4320

ttgtctttaa aagtgaaaag gattaagatt ttattctttc ttgtaaacat tacttgattt     4380

tttaaagaag ttttgggctc actgctaaaa tagagtatac aactgaatgt ttttaagtca     4440

agatactgtt ttaggagttt accctctcat ttataaccaa agttgctcta aaacactttc     4500

caaatatctg cacttctgat gtcagaatca aaccagataa ttctctaatt cttctttaat     4560

ctaaagtaga tagcttccca ctggaaagta aacaaaacca tccctcccaa cctcaaagct     4620

aggccacact ctatttcaag gcattttctt tcagctgata aggtgtcctc ctgaagccaa     4680

gtaggtggtt ctggtctcca agtatcgtta agcacaggtg ctatgacaga aaaagttctg     4740

gggtggaagt tttaagatga ggagttctga tcttaggcat cttaacagtc acaaggtgaa     4800

aagtcaaatg aaacagtaca attcttgatg agtgaggtgt catcttccaa ccacacagag     4860

gacgttttgg ctatgatcat ctgatggcaa gtgaaggaga aatgagtgat agggctttgc     4920

gttttcatcc agatgctgtg gccctgtgtt tcacagcatt aagagccata atttccaacc     4980

tgcacagatc ctgaacaaca aatgaataac gatgaatgtc tttttggttg taatttaaca     5040

agtcaaataa aataatcatt gctgagcaca atcacatgtt gaaa                      5084


<210>  41
<211>  2395
<212>  DNA
<213>  Homo sapiens

<400>  41
acagtacctc ctccctagga ctacacaagg actgaaccag aaggaagagg acagagcaaa       60

gccatgaaca tcatcctaga aatccttctg cttctgatca ccatcatcta ctcctacttg      120

gagtcgttgg tgaagttttt cattcctcag aggagaaaat ctgtggctgg ggagattgtt      180

ctcattactg gagctgggca tggaataggc aggcagacta cttatgaatt tgcaaaacga      240

cagagcatat tggttctgtg ggatattaat aagcgcggtg tggaggaaac tgcagctgag      300

tgccgaaaac taggcgtcac tgcgcatgcg tatgtggtag actgcagcaa cagagaagag      360

atctatcgct ctctaaatca ggtgaagaaa gaagtgggtg atgtaacaat cgtggtgaat      420

aatgctggga cagtatatcc agccgatctt ctcagcacca aggatgaaga gattaccaag      480

acatttgagg tcaacatcct aggacatttt tggatcacaa aagcacttct tccatcgatg      540

atggagagaa atcatggcca catcgtcaca gtggcttcag tgtgcggcca cgaagggatt      600

ccttacctca tcccatattg ttccagcaaa tttgccgctg ttggctttca cagaggtctg      660

acatcagaac ttcaggcctt gggaaaaact ggtatcaaaa cctcatgtct ctgcccagtt      720

tttgtgaata ctgggttcac caaaaatcca agcacaagat tatggcctgt attggagaca      780

gatgaagtcg taagaagtct gatagatgga atacttacca ataagaaaat gatttttgtt      840

ccatcgtata tcaatatctt tctgagacta cagaagtttc ttcctgaacg cgcctcagcg      900

attttaaatc gtatgcagaa tattcaattt gaagcagtgg ttggccacaa aatcaaaatg      960

aaatgaataa ataagctcca gccagagatg tatgcatgat aatgatatga atagtttcga     1020

atcaatgctg caaagcttta tttcacattt tttcagtcct gataatatta aaaacattgg     1080

tttggcacta gcagcagtca aacgaacaag attaattacc tgtcttcctg tttctcaaga     1140

atatttacgt agtttttcat aggtctgttt ttcctttcat gcctcttaaa aacttctgtg     1200

cttacataaa catacttaaa aggttttctt taagatattt tatttttcca tttaaaggtg     1260

gacaaaagct acctccctaa aagtaaatac aaagagaact tatttacaca gggaaggttt     1320

aagactgttc aagtagcatt ccaatctgta gccatgccac agaatatcaa caagaacaca     1380

gaatgagtgc acagctaaga gatcaagttt cagcaggcag ctttatctca acctggacat     1440

attttaagat tcagcatttg aaagatttcc ctagcctctt cctttttcat tagcccaaaa     1500

cggtgcaact ctattctgga ctttattact tgattctgtc ttctgtataa ctctgaagtc     1560

caccaaaagt ggaccctcta tatttcctcc ctttttatag tcttataaga tacattatga     1620

aaggtgaccg actctatttt aaatctcaga attttaagtt ctagccccat gataaccttt     1680

ttctttgtaa tttatgcttt catatatcct tggtcccaga gatgtttaga caattttagg     1740

ctcaaaaatt aaagctaaca caggaaaagg aactgtactg gctattacat aagaaacaat     1800

ggacccaaga gaagaaaagg aagaaagaaa ggttttttgg tttttgtttt gttttgtttt     1860

gttttttgtt tttttgagat ggagtctcac tctttcgccc aggctggagt gcagtggtat     1920

gatctcagct cactgcaagc tccacctccc gggttcacgc cattctcctg cctcagcctc     1980

ctgagtagct gggactacag gcgcccgcca ccacacccgg ctaatttttt gtattttttg     2040

tagagacggg gtttcaccat gttagccaag atggtctcga tctcctgacc tcgtgatcca     2100

cctgcctcgg cctcccaaag tgctgggatt acgggtgtga gccaccgtgc ccagcctttt     2160

tttttttaat agaaaaaata atccgactcc cactacatca agactaatct tgttttgtgt     2220

gtttttcaca tgtattatag aatgcttttg catggactat cctcttgttt ttattaaaaa     2280

caaatgattt ttttaaaagt cacaaaaaca attcactaaa aataaatatg tcattgtgct     2340

ttaaaaaaat aacctcttgt agttataaaa taaaacgttt gacttctaaa ctctg          2395


<210>  42
<211>  2276
<212>  DNA
<213>  Homo sapiens

<400>  42
tgagaatatc cagattctgc cctggaggcc tgcagggctg gtgtgttcag gaagctgttt       60

gaagatcaga gcagagccct gtccacagca aactaaaatg atggctatgt ggacatgagc      120

agcttcaaca cctttaagaa caatcagcag agcacagacc aggacgcaga aagacagagt      180

cttgccctgt tgcccaggct ggagtatagt agtgcagtgg tgtgatcata gctcactgta      240

acttcgacca cctgggctca aacaatcctt cttcctctgc ctcccaagta gctgggacta      300

cagagcagga cccaggatgc aagaccctag gcatccccaa ggccttccac tgtccccagg      360

ccttccaaag agacagcggc aggaccgcac aatctacaac tggaaacagc aggaagtgct      420

agaaaatcac tttaaggagg aacagtaccc agactatgac acacgacaag agctggcgga      480

gatgctcaat ctcagggagt accaagtgca ggtgtggttc aagaatcgcc gggccaaacg      540

ctctcgggag cggtggttcc agaagcagct ccagcagctc cagaagcatc ctcagcagca      600

gcatcctcag cagcagcatc cccagcagca gctccagcag cagcagcccc agcagcagcc      660

ccagcagcag cagccccagc agcagccaca gcagcagcag ccccagcagc agcagctcca      720

ccagcagccc cagtagcagc tctagcagca gcagcagcag ccccagcagc agcaactcca      780

gtagcagctc cagcagcagc agccccagca gtagctccag cagcagcagc agcagcccca      840

gtagcagctc cagcagcccc agtagcagct ccagcagcag cagcagcagc cccagtagca      900

gctccagcag ccccagtagc agctctagca gcagcagctc cagcagcagc agtcccagca      960

gcagcagccc cagtagcagc ggcagcagcc ccagtagcag caacagcagc cccagtagta     1020

gcagcagcag ccccagtagc agcagcagca gccccagccc ccgtagcagc agccccagca     1080

gcagcagctc cagcaccagc agtcccagca gcagcagtcc cagcagcagc agccccagca     1140

gcagctgccc cagtgcagcc ctgggcagga ggccacagag cccacagagc tcgcactgtg     1200

ccccctttcc ctgaagctgc ggcctctgcc ccccatcagc ctggcctctt gggaattctc     1260

ccacagggag aggccccgtg ggtattctcc cacaatctgc agcctccacc aggccttgag     1320

tagctttggg tgcagagcca ggagggcgtt tggctgtcct aggtctagcc cctggcccaa     1380

tcccagcccc attccaggcc cactcaaaag ccaaggccca atcccaggtc caggctcaat     1440

cctaggccct ggcctgattc caagccaggc ttactcccag gcccaggctt agtcctagcc     1500

ccaatcccag gtcctggccc aatcccaaac ttaggatccc tcccagcccc agccctagtc     1560

cccttgtgac ctcagagcac ttatgcctcc aatttcttgc cagacagtca ttccctgact     1620

tcacagagct cctcccaccc ctagaccagt tcgaggaatc cttggtctcc accacgacat     1680

ctcagtacca agagggggat ggctctatgg acaaaaagac tcgggcccca agtgattaat     1740

ggatttatag ggggcctgtg tctgcaaagt cctgcggata ccagtggacc tggagtggct     1800

ggttggtcta cactgctggt gaatgcacca ccaccattta accaccctgc cgctggtggg     1860

catttgctgt cttcactgtg tggccatcac gactagctct gctatgaatg cacctgccct     1920

catttgagtt gagcctgagc atttcgcagc tgggattgga gtcgctgctc atggggatgt     1980

ttggcattag tggatgctac ttgagagctt tgtaaagagc tttactcagc acttctgata     2040

gtcagcattc tccctgacac ttaggattgt gagacttttt aatgtttgtg gatccaatgg     2100

cttatggctt ccctgatgac tgagaggttg agaagttctc acatgttaat tgaaccttag     2160

aaatcctcat atgtgtccat ttgtttgccc atttttcttc atttatttga atgtattttt     2220

atattctctt gataattaaa gtgctgcaaa caccccccaa aaaaaaaaaa aaaaaa         2276


<210>  43
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  43
aatttctcac tgcccctgtg ataaactgtg gtcactggct gtggcagcaa ctattataag       60

atgctctgaa aactcttcag acactgaggg gcaccagagg agcagactac aagaatggca      120

cacgctatgg aaaactcctg gacaatcagt aaagagtacc atattgatga agaagtgggc      180

tttgctctgc caaatccaca ggaaaatcta cctgattttt ataatgactg gatgttcatt      240

gctaaacatc tgcctgatct catagagtct ggccagcttc gagaaagagt tgagaagtta      300

aacatgctca gcattgatca tctcacagac cacaagtcac agcgccttgc acgtctagtt      360

ctgggatgca tcaccatggc atatgtgtgg ggcaaaggtc atggagatgt ccgtaaggtc      420

ttgccaagaa atattgctgt tccttactgc caactctcca agaaactgga actgcctcct      480

attttggttt atgcagactg tgtcttggca aactggaaga aaaaggatcc taataagccc      540

ctgacttatg agaacatgga cgttttgttc tcatttcgtg atggagactg cagtaaagga      600

ttcttcctgg tctctctatt ggtggaaata gcagctgctt ctgcaatcaa agtaattcct      660

actgtattca aggcaatgca aatgcaagaa cgggacactt tgctaaaggc gctgttggaa      720

atagcttctt gcttggagaa agcccttcaa gtgtttcacc aaatccacga tcatgtgaac      780

ccaaaagcat ttttcagtgt tcttcgcata tatttgtctg gctggaaagg caacccccag      840

ctatcagacg gtctggtgta tgaagggttc tgggaagacc caaaggagtt tgcagggggc      900

agtgcaggcc aaagcagcgt ctttcagtgc tttgacgtcc tgctgggcat ccagcagact      960

gctggtggag gacatgctgc tcagttcctc caggacatga gaagatatat gccaccagct     1020

cacaggaact tcctgtgctc attagagtca aatccctcag tccgtgagtt tgtcctttca     1080

aaaggtgatg ctggcctgcg ggaagcttat gacgcctgtg tgaaagctct ggtctccctg     1140

aggagctacc atctgcaaat cgtgactaag tacatcctga ttcctgcaag ccagcagcca     1200

aaggagaata agacctctga agacccttca aaactggaag ccaaaggaac tggaggcact     1260

gatttaatga atttcctgaa gactgtaaga agtacaactg agaaatccct tttgaaggaa     1320

ggttaatgta acccaacaag agcacatttt atcatagcag agacatctgt atgcattcct     1380

gtcattaccc attgtaacag agccacaaac taatactatg caatgtttta ccaataatgc     1440

aatacaaaag acctcaaaat acctgtgcat ttcttgtagg aaaacaacaa aaggtaatta     1500

tgtgtaatta tactagaagt tttgtaatct gtatcttatc attggaataa aatgacattc     1560

aataaataaa aatgcataag atatattctg tcggctgggc gcggtggctc acgcctgtaa     1620

tcccagcact ttgggaggcc gaggcgggcg gatcacaagg tcaggagatc gagaccatct     1680

tggctaacac ggtgaaaccc cgtctctact aaaaatacaa aaaattagcc gggcgcggtg     1740

gcgggcacct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacctgg     1800

gaggcggagc ttgcagtgag ccaagattgt gccactgcaa tccggcctgg gctaaagagc     1860

gggactccgt ctcaaaaaaa aaaaaaaaaa gatatattct gtcataataa ataaaaatgc     1920

ataagatata aaaaaaaaaa aaaa                                            1944


<210>  44
<211>  10396
<212>  DNA
<213>  Homo sapiens

<400>  44
cgggcctggg ctgtggctgt gactggcgct gccgtgggcg ccgcagccct cgcgggagcc       60

ggacgcggta atgccccagc ggcgcagcgg gcggctgcgt ccctgagccg ctatataagc      120

gcggcaggga acatccggag gggctgaaga tgaaggtgcc cgcgcatggg cccccgctga      180

ttgccagtcc ctcccgaccc cgcgccccgc gcggagcccg aggccgccga ggacccgcct      240

tcgccgcagt agcagctgga gcagcgacag aggcggcagc tgcggcggcg gcggcgcccg      300

cgcccctcgc gccagcgcgt agagcggcgg cggcagctcg ggggccgcca ctgccccggc      360

tgccatgagt tgtgcggagg tgatgtatca cccccagcct tatggagcgt cccagtatct      420

gcccaacccc atggcagcga caacctgccc cacagcctac tatcagccgg cgccccaacc      480

tggccagcag aagaagttag cggtattcag caagatgcag gactctctgg aagtcaccct      540

tcccagcaaa caagaggagg aggatgagga ggaggaggag gaggagaaag accagcctgc      600

cgagatggag taccttaact ctcgctgtgt ccttttcact tatttccagg gagacattgg      660

gtcagtagtg gatgaacact tctcaagagc tttgggccaa gccatcaccc tccatccaga      720

atctgccatt tcaaaaagca agatggggct aaccccccta tggcgagaca gctcagctct      780

ctcaagccag cggaatagtt tcccaacttc cttttggacc agctcttacc agcccccacc      840

tgcaccttgt ttggggggag ttcatcctga cttccaggtc actggacccc ctggcacctt      900

ttctgcagct gatcccagtc cttggccggg acacaacctg catcagactg gcccagcccc      960

tccccctgct gtgtctgagt cctggcctta tcctttgaca tctcaggtga gcccatccta     1020

cagccatatg catgacgtgt acatgcggca ccaccaccct catgcccaca tgcaccaccg     1080

ccaccgccac catcatcacc atcaccaccc tcctgctggc tctgccctgg atccatccta     1140

tgggcctctg ctgatgcctt cagtgcatgc ggccaggatt cctgctcccc agtgtgacat     1200

cacaaagaca gaaccaacta cagtcacctc tgctacctca gcatgggctg gagcctttca     1260

tggaacagta gacatagtgc ccagcgtggg attcgataca ggtctacagc atcaagacaa     1320

gagtaaggaa tcaccgtggt actgaaacac acaatcttag tgagttaagt tgcagcataa     1380

atccaagggc ccactgggaa aagatactgt cgggtttttc cattcagcaa taggacacga     1440

aaggcataga aggagaagac aaagtgtcac gcagttgact ggttttcggc ctttcttgag     1500

aaagcaaagt gggtcccaga cattgaagaa aagcattttt atttgtttat ttcctcatct     1560

gagcctttgc caactgtgca actctctcct tttgttatct tgcttttatc aatatatagc     1620

taagtttttg tttcattttg attttttttt ttagccaacc accttgtcag gaaaggatga     1680

accacacatt aaaatgttca ttctttcagg aatacaagtt tgtagctcta tgtgcatcta     1740

tttttgtaga aatacaaaaa gtttggttta gcattgatgg gctatttttg agggatgtat     1800

tttttttaaa attgtaaaaa ttgttgagtt ctgtttaaag aacttgctct cagagaagca     1860

ctggcaaaaa tgtttaaaat gcttatctct aagatgtcta ttatatgctc tgtctgtgct     1920

ttctaggtta cctcaaatgt tttgtttttt tccttcttac aaaagtagct ataccgtagt     1980

caaaccaatg cagtattgtt tttacattga atctcagtaa agatttaatt ccatgctagc     2040

tcaattagtt ttgaattata tgtatagctt gaaaagtttt tttttaatga ctgtgctaaa     2100

gaaatgatat tttattgctt tgatttctcc caaagaataa cttggaggtt gactaataag     2160

aaagttggca taaactttca atcaaatgaa gagtttgcct agaggagact aattctcttt     2220

ctagcccatc caaatttgat aaatggaacc agaggttata tacaactaca aggaaaaaaa     2280

tgcatttaac catgccacct atgagtgcca gtgacttatt ttacttgttt ttaattattc     2340

attcatggca atttaaaaag tcatatttta agtgggattt gtttttcctg aagggcattt     2400

gaaggaacaa tatctgggaa ggtactagag aaattacaaa gcccgagctc tttcttataa     2460

tgccacctat ccctgtaagc taaacaaaca aacaaacaaa caaacaaaca gttctatata     2520

taatagtttc aacacagaac ttaacaagtc tctttttttg tttgtttaaa tctggcttta     2580

cttgatttaa ttccttttta gaaagaaatt tagggcaaaa taaagtgtat attaggattt     2640

aaatttatgc cacaatttaa aaataaaacc agaggttata tacaatttaa attgggctaa     2700

aaattaaaaa tttgaggatt taacttgata tagctctcag gatctaaata aagtttaaat     2760

tatcattaag acactgctag gagaagatta agattatgaa agtaacagtt attgatactg     2820

ctggacttca aaggcaaagt tcatttcttc cattaactgc ttccagagat gtcatgtaaa     2880

aaagttagtg tattagagaa gttttttagc tttataaaga ggttttttca aatttctccc     2940

atttttctct ccacccacat aaaatagtat gttcagtgaa atgccacttt ctatctttaa     3000

ttgttcgtat catatatgcg aactttttag acatgaacat gacatgttca gctaggcaga     3060

gttctcatag ataattttca aatattttcc ttggctgtaa tttatgtatt catttatatc     3120

ctatccgtct tttgagcttc agatctatat actcttttgt actctcatca ctccgcactt     3180

tgctgtttct tacctagact ctcttttaca caatatgcac atttttacca ttgtggggtc     3240

caaatttaag ataccttcca ctcactaata atatgaactt atatttcctg ggagtagcca     3300

ggttaaattt tctatacttt ggtccataat ttgatttgat atgattgttt catttataat     3360

ttgcccaaat acatggagca caaaatttag tgaatttata aatctggatt tgccttgtgt     3420

ccttctgagt tttcaaaggc aagtattcaa cagtccctgt gtgatgactg acagggttat     3480

ttgcctcatc cacatccacc ttcggaatac attaacttcc tttgtaattt atttgaaagt     3540

agtgttaaac tcattcagat cattcagttg gattttccca atgaagagga aaaggaaagt     3600

agttattcct agctccattt cttattttcc accaaattta attgaagggc attaattaga     3660

tgtcttcacc ctgaatttag actttgctct gtgttctccc ggtaactgtc agacaaaaag     3720

tttattggct ctgaggaact gagaaatgtt gggaacctgg tttctgctgt acacaggaaa     3780

gatttgtaag tgagctctct ctttgaaaac aggacccagg ctgggcacag cagctcatgc     3840

ctgtaatcct agtattatag gaggcagagg ctcgggagga ttgcttgagc ccaggagttc     3900

aagatcagcc taggcaacat agggagaccc tatccctaca aaaaatttct gaaaaattac     3960

ctgggcattg tggggcacac ctgttgtccc agctactctg gaggctgagt ccggaggaac     4020

gtttgagcct gggagtttga gtttgcagct tgcagtgagc tgtgattgca ccactgtact     4080

ccagcttggg caacagagca agatcctgtc tcaaaaggaa aaagaaaaca ggacctaggt     4140

gtttggggta cactgccacc cagggagtgg atcaaaaata tacatagaaa gagaatgagc     4200

atgtctctat aattgtcttc taggaccata ttgctgttag aagtcctaaa agaggatggg     4260

ttgtaattta gcataatatt ctgaattcat tccaagttta aaatcctgtc attctctggc     4320

tcttcttttt tcacatcaaa atgatgctgt tggacttaga ggcttccgaa ctgttttatt     4380

gagggctact atctgcctcc acaattttat taaaaccact ccacctttag acaaaggtga     4440

cttttgtctg attttacaaa tcagatttta ttcaagcttt ctaaatatct gtgaagtaga     4500

ccctagaaaa ttgtctcgtt tattttaaat agaatctatg cttccaccaa taaaccatcg     4560

ggagctaaga aacaacataa tgttgacaaa tcaggaacct aacagattat tttgtctctc     4620

attattaatt tgaaagagcc tctaaacttt tgagaaatca atgtgtcttc ttaagaaagt     4680

taagcaccct ctcttaactt tcccctctat ttgctctcct ttttctttct tcttaagagt     4740

atttatatta ttttgttaag caaaaatggc taagattgct ctaaaatttg caaaatgagg     4800

agtggattgc aaataattga gggatttatt tctttaactt tataagactt taaaaaaaaa     4860

acccaaattc taagcactga catgaaagtt gcctttgaga agcttgttat tcattataca     4920

aaaagtattt gcccattcct attctaagat ttgcagaata tgtcacccta tctagctttt     4980

gagtttgcta tctggtttaa tgttgtattt ataatttaaa gtggaaatca gaaactgttt     5040

caagaacctg tattctattc cttactgagt gtcccttctt taaatagtgt ttgctgaatt     5100

aagccgatgg gggcagtggc gttaagtggt ggaaaaagga aagtatatat gttagagttt     5160

tgaatgaggg ataaatagaa agcagaatga attaatggaa aagaactcgg ctgttaggcc     5220

attctctaaa ttctagttta gccaaaagtt tatgtgtggt ttggggcttc atttatttat     5280

ctcatgagta aaatggaata atacctaaca ggcaggctct ggaagttgga aatcacatac     5340

acacacacac acacacagac acacacacac acgatcaatc atgtagctca tattagatgt     5400

tcaataaata acagctacta cagatgccta tcagttgagt aagtagttca ttaaattgag     5460

ctcccaaagg tctcttctct tcacatccat atccgtttct gcagcaatca aatagataca     5520

tgattgtttt tctgtaagaa attactgcaa agagaatctt tttctcctac taactgttcc     5580

ttctacctgg tataggagat aaatgtacgt ttcttaatta gctgactttt tagtatgtca     5640

tttctgaagg aaaaataaat taaccttaaa gtggcatgta ggtccaattc agttttccta     5700

catgttccaa aattttattt aaattactgt gtccaaaatt atgaggacag tgtcattcat     5760

tcaccatagt ttatattttt agttatatat caaacttcct tggcacctag gataagaaca     5820

tttcttttga agttatccaa ttttttttta tttttacttg acttgaagga aagttggaaa     5880

atatggtgga aaaaatcttc cgcattaaaa gggggaaaaa cacaaccatt tacgatctca     5940

gtcagcagat ttactctact caaggaaaaa aagaaacaat cttattggaa gcagatgttg     6000

acactgtgtc agttattgaa gacggaagga gttcacttga gccattgcag ttacaaaggg     6060

gtattgatgg cagtttggat tcctgattga tcacctttgc agccaaggga aagacagcag     6120

aaactgtatg ggatcagaaa tgaaatcagc ctgccagttt aatggagagg ctcctagaaa     6180

ctcatttttt ttctttcctg taagataaaa gacatctttc agaataagaa aggcttgttt     6240

gagagagaaa ttacagttta ttctctgaaa atatttaaag gccaaagtgc cctttaaatc     6300

tattattaaa gcattgaaac tgttattaaa atcattatag aaaaattagg taaaaatttt     6360

agcctaactt tcaacatcca ttcaaaaacg aatgttgaaa acaaacatat aacctataaa     6420

aaagtgaatg gctctggcaa gtgggggcat gggtggagtc cataaggaaa cctcagtctc     6480

aataacttca aaatgttact tttcatggta acttggtcat ggagattggt cacagcacag     6540

acatttagaa ttttttagca ggtttttttt ttcttttgaa tcttgtagtg ctctctggga     6600

attgcaccat gtacactttt acaacctaca gaaatcgtca ttattgttaa agtatctcaa     6660

cttttctatt tcttttattg tctattgtgc ttttttgttt aaaaatactt ttatagtttt     6720

aaagtattgg tcaaagtagt attctcttga agttctagtc aatttaattt gatccaataa     6780

gtttttctga atctcctttt taagttccaa gaaattctat tataaataag tgtactttta     6840

ccaattccat tgtataagca aacagacacc ttttagaaaa ggataagtaa tcatcaattt     6900

gtttttttaa aaaaaaaaac aatttctaga ctactaaatt tggcataaga ataattcttt     6960

taaaatgcaa catactttaa ttagtttttt tggtatatgc ataagatgtg aactttccta     7020

ttgatatcac tttatattaa tagagatgta catttctttc tatgccgtgg ctagagcaaa     7080

agttaataat gattatttac acaattgatt taatttctta ggatatgtat aatattggat     7140

attatatctg atttaaaaat actattccat acattttttt tttcaggaga taaaacatag     7200

ggaaaggttt tcatgtgaat tctttgtatc actttgaagt acatatattt aaagggaaga     7260

tggatacaat ttgtttttat tatataaatc taggtaaggt gaaatgcttt tgtcaacaaa     7320

aatacagtgt agtgaatttt atatttgtca cttgattagg taaactgaaa actaacaata     7380

gaaatattat tttactgcat tgaaatacca tgaactttca gacttgttag ttctacaaga     7440

agttgtgcta ccttaatttt gtgtttccag aaataaaaat taaccttagt tatgctgtca     7500

tttttaacta ataaaaaaag tataattcat aaaacttttg gctttataag ataattataa     7560

aattatatat ttttttctgt ttttgtgggg ttgggaaaac attttcttat ttctattcac     7620

tcttcaaatg caggtctcat aatatgtgtc aatgatataa gatgatggaa gactttgtaa     7680

taaaaacata tgtcattatc ttcaatttgt tcaataaata atttaatgtg aattgaatgt     7740

ttgtatttta acatagcatt tggatttggt ctgcatttct tgagaattta aagctctttt     7800

tgtttcctcc ttattcaatt aagcatctta taaatatttt ggaaattaca acatcttagg     7860

tgttattaat taagaagtta atttctaggg ccaagaagtc tatatgttac agcaaggaat     7920

agattataaa atacatgttt ataatggaaa agaaaatgaa atggggtata ttaattacat     7980

aacagcaaga gtcttgagaa ttttataata caatgcttct aaggatattg gttgaccaag     8040

gtgtatttta ttgtttttac atttgttgac agggactctg ccataagtag tatgaaaaaa     8100

caaacaaaaa cttttctacg attcattaac attgaaaaga gaattccaag accttgtatt     8160

ctgaagaaag ctagagtttc tctaagtggg ccttcaattt tcttattaca cgtatcttta     8220

atgtgaaagt actaaagtct gaaaatcagc atttaaataa tagactttcc agcattacag     8280

atgaaataat ttggcgcagg ctttttaact gtctaccata tttagaatgt ggtgtcaaaa     8340

tgagattttt agaactgctg taaaatatta ctacattact acaacgataa cggcctaaaa     8400

caacacaaat ttattatctt acagctctgt cagtcagaca ttcagcaaag atcttagtct     8460

tggtgggcta cagaatgtag gaggcatttc ctggatgctt ccaagagaga atcttgctgt     8520

tccctgcttc tagagtcctt tgcttagttt ccttccatct tcaaatccag caacctggtc     8580

aagaccttct cacatgacat cactgacttc ctcttcttcc tctcccttac atatttaagg     8640

actcatgtga ttacaatagc tgcatctgtg taatccagaa taatctcttc atctcaaggt     8700

ttttgttctg ttttgttttt ttgttttgtt ttgttttgtt ttgttttgat ggagtcttgc     8760

tctgtcgtca ggctggagtg cagtggcgcg atctcggctc actccaacct ccacctcccg     8820

ggttcaaagg attcccctgc ctcagcctct cgagtagctg ggactacaga tgcgtgctac     8880

cacacaaggc taatattttg tattttagta gagacgggat ttcaccatgt tggccaggat     8940

ggtctccgtc tcctgacctc gtgatctgcc tgccttggcc tcccaaagtg ttgggattac     9000

aggcataagc cattgcgcca tgctcaaggt tcttaattac atctttaaag gccctttttc     9060

catgtacagt aacatattca atggttctgg ggattaggac ttggagccat tattctacct     9120

acaacaatta gtattggact tccatcattt tctatcactc ttgtaatcga gaaggactat     9180

ttcactggga gtagcaagtc ataatgtttg cgttggcatt tgtgtggggg tttatcttca     9240

ttcattaaat aattgcatgt aaagaaaatt cctgtcacta tttcaaatgt ttcatgtagt     9300

tattatagtg cttcagaatc caaagggtta tgtgttactt atgtaagatg agcagtctag     9360

ggggtggaga acaggtcatc tagtgcagat tcttcctagc tgaagtgtgt tttctctggg     9420

gacaaccaag taggatttaa ttgttttgct tccttttttg ggaacttaga cccatcttgc     9480

gatgtcctaa gtctccaagc atcttatttg acctgcttat acacatttga ctaaatagct     9540

aaatatgacc acattgacgt ggtaaagctt taacactttt gtccagattg aatcactcca     9600

tctgctatca gttaagcagt ggaaaactgt tatggaaaag caaacatgtt ttgatagatt     9660

taatgtgtaa agaaggtatc catactctgg aatgctgctg atcaataaat gagctgcaag     9720

actttgttcg aaacaacact caagcacaac tgttttactt tccataccaa gtttggctgt     9780

gactgaatga agaacatcag cattgatctt tgctttgcac ttgtacaaga gactatttgc     9840

agagagccaa atatagcaac agaggattta atatcttgcc aaaaaataca aaatctgttc     9900

ccctttaagc atgacactct atcctttctt gtggatcttg ctaaaaggaa aatatagctt     9960

taaactcccc tattccttct gttgaaagct taagaatctt tttcaaatga gctatgtatg    10020

gttttgtggt attttatgtt tccaaaagaa aatggctaca tgaaaaatct gtccagtgtt    10080

atcatttttc ttacaaaaaa tacttctagt tatggttgta ttaattaatt tgattgtgat    10140

aatgattaca caatgtttac ctatatcaaa tcatcatatc gtatacctta aatatatata    10200

acttttatgt gtcaattata actcagtaag tctgggaaaa tatcgttaag tcaaagatta    10260

gagtcaacag aaataaagaa aaatcatact ttgataactt caggactaat caaggatcaa    10320

tgggtgacat gatatcatgc tatgtgccat tttgtgttaa acaaattaca ccaacaataa    10380

aaaaaattgg cttcaa                                                    10396


<210>  45
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  45
actcgccacc tcctcttcca cccctgccag gcccagcagc caccacagcg cctgcttcct       60

cggccctgaa atcatgcccc taggtctcct gtggctgggc ctagccctgt tgggggctct      120

gcatgcccag gcccaggact ccacctcaga cctgatccca gccccacctc tgagcaaggt      180

ccctctgcag cagaacttcc aggacaacca attccagggg aagtggtatg tggtaggcct      240

ggcagggaat gcaattctca gagaagacaa agacccgcaa aagatgtatg ccaccatcta      300

tgagctgaaa gaagacaaga gctacaatgt cacctccgtc ctgtttagga aaaagaagtg      360

tgactactgg atcaggactt ttgttccagg ttgccagccc ggcgagttca cgctgggcaa      420

cattaagagt taccctggat taacgagtta cctcgtccga gtggtgagca ccaactacaa      480

ccagcatgct atggtgttct tcaagaaagt ttctcaaaac agggagtact tcaagatcac      540

cctctacggg agaaccaagg agctgacttc ggaactaaag gagaacttca tccgcttctc      600

caaatctctg ggcctccctg aaaaccacat cgtcttccct gtcccaatcg accagtgtat      660

cgacggctga gtgcacaggt gccgccagct gccgcaccag cccgaacacc attgagggag      720

ctgggagacc ctccccacag tgccacccat gcagctgctc cccaggccac cccgctgatg      780

gagccccacc ttgtctgcta aataaacatg tgccctcagg ccaaaaaaaa aaaaaaaaaa      840


<210>  46
<211>  6351
<212>  DNA
<213>  Homo sapiens

<400>  46
agatcccgtc ctcccgcctc gcacccatca gcgcggaccc cgggggcgac gcagtggcga       60

tgtcgggctg tgggcccagc ggtggcacta ggcggagaag caccactcaa ccccatccct      120

gggctgcaga gggcccagcg cggggggctc cgagcgtcgg gagcctgtgg aagagaagag      180

cgcgcgggcg acagttaaac aggccctggg gcagggcgcg cctcgcgctc cagggagccc      240

cgccctcccg cggcacctcc gcagcaaccg ccgcctgcac tgggcgcgcg agagctgcta      300

gggcggtttc tctgcctcgg gcctgttggg cagggccggc taaggtgcgc gtgctcgctg      360

gttctaaccc ttctgttggg cgtttctgct gagaggcggg aggcgctgag agtctgtgcg      420

aaggtccgtg gacagactgc tttgcctgtt gttgctcttc ggaggcggcg atccccgaag      480

gcgagctgaa atacggctgc aggctacaat ttgcagccga ccattatgga tgacaaggag      540

ccgaagaggt ggcccaccct cagggaccgc ttgtgctcgg atggcttctt atttccccaa      600

taccccatta aaccgtatca tctgaagggg atccacagag ctgtcttcta tcgtgatctg      660

gaggaactga agttcgttct gctcacgcgt tatgacatca ataagagaga caggaaggaa      720

aggaccgccc tacatttggc ctgtgccact ggccaaccgg aaatggtaca tctcctggtg      780

tccagaagat gtgagcttaa cctctgcgac cgtgaagaca ggacacctct gatcaaggct      840

gtacaactga ggcaggaggc ttgtgcaact cttctgctgc aaaatggcgc cgatccaaat      900

attacggatg tctttggaag gactgctctg cactacgctg tgtataatga agatacatcc      960

atgatagaaa aacttctttc atatggtgca aatattgaag aatgcagcga ggatgaatat     1020

ccgccactgt tccttgctgt gagtcaaaga aaagtgaaaa tggtggaatt tttattaaag     1080

aaaaaagcaa atataaatgc cgttgattat cttggcagat cagccctcat acatgctgtt     1140

actcttggag aaaaagatat agtcattctt cttctgcagc acaatattga tgtgttttct     1200

cgagatgtgt atggaaagct tgcagaagat tatgccagcg aggctaagaa cagagtcatt     1260

tttgaactaa tttatgaata tgaaagaaag aaacatgaag agctttctat aaatagcaat     1320

ccagtgtctt ctcagaaaca accagccttg aaggctacaa gtggcaagga agattctatc     1380

tcgaatatag ccacagaaat aaaggatgga caaaaatctg ggacagtgtc ttctcagaaa     1440

caaccggcct tgaaggatac aagtgacaag aacgattctg tttcgaacac agccacagaa     1500

ataaaagatg aacaaaaatc tgggacagtg cttcctgctg ttgaacagtg tttaaacagg     1560

agtctctaca gaccggatgc tgttgcacag cctgtgacag aggatgagtt tgctttggaa     1620

tctgagatta tttcaaaact atacatccca aagagaaaga ttatttctcc acgatctata     1680

gaagatgtgc ttcctcctgt tgaagaggct gttgacaggt gtctctacct actggaccgt     1740

tttgcacagg ctgtgacaaa ggataagttt gctttggaat ctgagaatat ttcagaacca     1800

tactttacaa acagaaggac tatttctcaa caatctgcag aaaagttaga tgctgcatgt     1860

ggcattgaca aaacagaaaa tggaaccttg tttgaagacc aaaatgttga taaggaagga     1920

aaagcactac cagcaactgg acaaaaagca aatgtgtctc ctgagcaacc gcctttattc     1980

acgcatacgg tgaaagacag tgatcacatt tcaactagat tcttaggaag tatggattca     2040

ctaacttcca gtgaagaatc ttctgagcga cctcctttat ccacgcttac tctgaaagag     2100

gcagatccca gttcaaaagc agccatgaga aggaaggatt caccacctcc aggaaaagtg     2160

tcttctcaga aacaaccagc tgagaaggct acaagtgacg acaaagattc tgtttcaaat     2220

atagccacag aaataaagga gggaccaata tctgggacag tgtcttctca gaaacaacca     2280

gctgagaagg ctacaagtga tgagaaagat tctgtttcaa atatagccac agaaataaag     2340

gagggacaac aatctgggac agtgtctcct cagaaacaat cagcctggaa ggttatattt     2400

aaaaagaaag tttctctttt gaatattgcc acaagaataa cgggcggtgg gaaatctgga     2460

acagtgtctt ctcagaaaca accaccctca aaggctacaa gtgacaagac agattctgct     2520

ttgaatatag ctacagaaat aaaggatgga ctacaatgtg ggacagtgtc ttctcagaaa     2580

caaccagcct tgaaggctac aactgacgag gaagattctg tttcgaatat agccacagaa     2640

ataaaggatg gagaaaaatc tgggacagtg tcttctcaga aacaaccagc cttgaaggct     2700

acaactgacg aggaagattc tgttttgaat atagccacag aaataaagga tggagaaaaa     2760

tctgagacag tgtcttctca gaaacaacca gccttgaagg ctacaactga cgaggaagat     2820

tctgtttcga ttatagccac agaaataaag gacggagaaa aatctgggac agtgtcttct     2880

cggaaaaaac cagccttgaa ggctacaagt gacgaggaag attctgtttt gaatatagcc     2940

agaggaaaag aggatggaga aaaaactagg agagtgtctt ctcggaaaaa accagccttg     3000

aaggctacaa gtgatgagaa agattctttt tcgaatataa ccagagaaaa aaaggatgga     3060

gaaacatcta ggacagtgtc ttctcagaaa ccaccagcct tgaaggctac aagtgacgag     3120

gaagattctg ttttgagtat agccagagaa gaaaaggatg gagaaaaatc taggacagtg     3180

tcttctgagc aaccaccagg cttgaaggct acaagagatg agaaagattc tcttttgaat     3240

atagccagag gaaaaaagca tggagaaaaa actaggagag tgtcttctcg gaaaaaagca     3300

gccttgaagg ctacaagtga tgagaaagat tctttttcaa atataaccag agaaagaaag     3360

gatggagaaa catctaggac agtgtcttct cagaaaccac cagccttgaa ggctacaagt     3420

gacgaggaag attctgtttt gaatatagcc agagaaaaaa aggatggaga aaaatctaga     3480

acagtgtctt cagagcaacc accaggcttg aaggctacaa gagacgagaa agattctctt     3540

ttgaatatag ccagaggaaa aaagtatgga gaaaaaacta ggagagtgtc ttctcagaaa     3600

ccaccagcct tgaaggctac aagtgacgag gaagattctg ttttgaatat agccagagaa     3660

aaaaaggatg gagaaaaatc tagaacagtg tcttctgagc aaccaccagg cttgaaggct     3720

acaagagatg agaaagattc tcttttgaat atagccagag gaaaaaagca tggagaaaaa     3780

actaggagag tgtcttctcg gaaaaaagca gccttgaagg ctacaggtga cgaggaagat     3840

tctgttttga atatagccag agaaaaaaag gatggagaaa aatctagaac agtgtcttct     3900

cataaacaac cagccttgaa ggctacaagt gacaaggaaa attctgttcc gaatatggcc     3960

acagaaacaa aggatgaaca aatatctggg acagtgtctt ctcagaaaca accagccttg     4020

aaggctacaa gtgacaagaa agattctgtt tcgaatatac ccacagaaat aaaggatgga     4080

caacaatctg gaacagtgtc ttctcagaaa caactggcct ggaaggctac aagtgtcaag     4140

aaagattctg tttcgaatat agccacagag ataaaggatg gacaaatacg tgggacaggt     4200

attttggaat acacctttaa tgtaatgttc gatcaaatag aagagaaatt cacttcccca     4260

aataaatcag cgggggtgtc tcctcagaaa caatcggccc agaaggttat atttaaaaag     4320

aaagtttctc ttttgaatat tgccacaaga ataacgggcg gttggaaatc tggaacagag     4380

tatcctgaga atctgcccac cttgaaggct acaattgaaa ataaaaattc tgttctgaat     4440

acagccacca aaatgaaaga tgtacaaaca tccacaccag cagaacaaga cttagaaatg     4500

gcatcagagg gagagcaaaa gaggcttgaa gaatatgaaa ataaccagcc acaggtgaaa     4560

aaccaaatac attctaggga tgaccttgat gacataattc agtcatctca aacagtctca     4620

gaggacggtg actcgctttg ctgtaattgt aagaatgtca tattactcat tgatcaacat     4680

gaaatgaagt gtaaagattg tgttcaccta ttgaaaatta aaaagacatt ttgtttatgt     4740

aaaagattaa cagaacttaa agataatcac tgtgagcaac ttagagtaaa aattcgaaaa     4800

ctgaaaaata aggctagtgt actacaaaag agactatctg aaaaagaaga aataaaatcg     4860

cagttaaagc atgaaacact tgaattggaa aaagaactct gtagtttgag atttgccata     4920

cagcaagaaa aaaagaaaag aagaaatgtt gaagagttgc accaaaaagt tagggaaaag     4980

ttaagaatca cagaagagca atataggata gaagctgatg tgacaaaacc aattaaaccg     5040

gctctcaaat cagcagaggt ggaattgaag acaggaggaa ataattcaaa tcaggtttct     5100

gaaactgatg aaaaagaaga cctgctgcat gaaaaccgct tgatgcaaga tgaaattgcc     5160

aggctcaggc tggaaaaaga cacaataaaa aaccaaaacc tggaaaagaa atacttaaaa     5220

gactttgaaa ttgtgaaaag aaagcatgaa gaccttcaaa aggctctaaa acggaatgag     5280

gaaacattag cagaaacgat agcctgttat agtggacagc ttgctgctct gacggatgaa     5340

aacacaacgc tccgttctaa actggagaag caaagagaga gcgggcaaag actggaaaca     5400

gaaatgcaat cataccgttg tagactgaat gctgctctat gtgatcatga tcaaagtcac     5460

tcatcaaaaa gagaccaaga gcttgctttc cagggcacag tagataaatg ttgtcattta     5520

caggaaaatt tgaattctca tgttctgatt ctttctctgc aactttctaa agctgagagt     5580

aagttcagag tcctcgaaac tgagctccat tacacaggag aggctctgaa agaaaaggct     5640

ttggtttttg aacacgtgca aagtgagcta aagcaaaaac agagtcaaat gaaggacatt     5700

gaaaaaatgt acaaaagtgg atacaataca atggaaaaat gcatagaaaa gcaggaaaga     5760

ttttgtcaac taaaaaaaca aaatatgttg cttcaacagc aactggatga tgctcgcaac     5820

aaagctgaca atcaagaaaa agcaatactt aatattcaag ccagatgtga tgctagagta     5880

gaaaaccttc aagctgagtg cagaaagcac cgtctcttac tagaagaaga caataaaatg     5940

ttggtgaatg aattgaatca ttcgaaagaa aaaaaatgcc aatatgaaaa agagaaagca     6000

gaaagagaag tagctgtgag acagcttcaa caaaaacaag atgatgtctt aaacaaacga     6060

tcagcaacaa aagctttgct ggatgcttca tcgcgtcact gcatctattt agaaaatggg     6120

atgcaggatt caaggaagaa attagaccag atgagaagtc aatttcaaga aatacaggat     6180

caacttacag ctactataag atgtactaag gagatggaag gcgacgcaca aaagcttgaa     6240

gtagaaaatg tcatgatgag aaaaattatt aaaaaacagg atgaacaaat tgagcggttt     6300

gagaaaatcc tgcagcattc aagtttgatg ctgcaggtgt ttgagagcta g              6351


<210>  47
<211>  15735
<212>  DNA
<213>  Homo sapiens

<400>  47
ggtctaaagg gctttatgca ctgtctggag ggtggggact ggcgcgggta gaaaacggga       60

tgcctcgggc gtgggggcag gcttttggcc actaggagct ggcggaggtg cagacctaaa      120

ggagcgttcg ctagcagagg cgctgccggt gcggtgtgct acgcgcgccc acctcccggg      180

gaaggaacgg cgaggccggg gaccgtcgcg gagatggatc gcgggccggc agcagtggcg      240

tgcacgctgc tcctggctct cgtcgcctgc ctagcgccgg ccagtggcca agaatgtgac      300

agtgcgcatt ttcgctgtgg aagtgggcat tgcatccctg cagactggag gtgtgatggg      360

accaaagact gttcagatga cgcggatgaa attggctgcg ctgttgtgac ctgccagcag      420

ggctatttca agtgccagag tgagggacaa tgcatcccca actcctgggt gtgtgaccaa      480

gatcaagact gtgatgatgg ctcagatgaa cgtcaagatt gctcacaaag tacatgctca      540

agtcatcaga taacatgctc caatggtcag tgtatcccaa gtgaatacag gtgcgaccac      600

gtcagagact gccccgatgg agctgatgag aatgactgcc agtacccaac atgtgagcag      660

cttacttgtg acaatggggc ctgctataac accagtcaga agtgtgattg gaaagttgat      720

tgcagggact cctcagatga aatcaactgc actgagatat gcttgcacaa tgagttttca      780

tgtggcaatg gagagtgtat ccctcgtgct tatgtctgtg accatgacaa tgattgccaa      840

gacggcagtg acgaacatgc ttgcaactat ccgacctgcg gtggttacca gttcacttgc      900

cccagtggcc gatgcattta tcaaaactgg gtttgtgatg gagaagatga ctgtaaagat      960

aatggagatg aagatggatg tgaaagcggt cctcatgatg ttcataaatg ttccccaaga     1020

gaatggtctt gcccagagtc gggacgatgc atctccattt ataaagtttg tgatgggatt     1080

ttagattgcc caggaagaga agatgaaaac aacactagta ccggaaaata ctgtagtatg     1140

actctgtgct ctgccttgaa ctgccagtac cagtgccatg agacgccgta tggaggagcg     1200

tgtttttgtc ccccaggtta tatcatcaac cacaatgaca gccgtacctg tgttgagttt     1260

gatgattgcc agatatgggg aatttgtgac cagaagtgtg aaagccgacc tggccgtcac     1320

ctgtgccact gtgaagaagg gtatatcttg gagcgtggac agtattgcaa agctaatgat     1380

tcctttggcg aggcctccat tatcttctcc aatggtcggg atttgttaat tggtgatatt     1440

catggaagga gcttccggat cctagtggag tctcagaatc gtggagtggc cgtgggtgtg     1500

gctttccact atcacctgca aagagttttt tggacagaca ccgtgcaaaa taaggttttt     1560

tcagttgaca ttaatggttt aaatatccaa gaggttctca atgtttctgt tgaaacccca     1620

gagaacctgg ctgtggactg ggttaataat aaaatctatc tagtggaaac caaggtcaac     1680

cgcatagata tggtaaattt ggatggaagc tatcgggtta cccttataac tgaaaacttg     1740

gggcatccta gaggaattgc cgtggaccca actgttggtt atttattttt ctcagattgg     1800

gagagccttt ctggggaacc taagctggaa agggcattca tggatggcag caaccgtaaa     1860

gacttggtga aaacaaagct gggatggcct gctggggtaa ctctggatat gatatcgaag     1920

cgtgtttact gggttgactc tcggtttgat tacattgaaa ctgtaactta tgatggaatt     1980

caaaggaaga ctgtagttca tggaggctcc ctcattcctc atccctttgg agtaagctta     2040

tttgaaggtc aggtgttctt tacagattgg acaaagatgg ccgtgctgaa ggcaaacaag     2100

ttcacagaga ccaacccaca agtgtactac caggcttccc tgaggcccta tggagtgact     2160

gtttaccatt ccctcagaca gccctatgct accaatccgt gtaaagataa caatgggggc     2220

tgtgagcagg tctgtgtcct cagccacaga acagataatg atggtttggg tttccgttgc     2280

aagtgcacat tcggcttcca actggataca gatgagcgcc actgcattgc tgttcagaat     2340

ttcctcattt tttcatccca agttgctatt cgtgggatcc cgttcacctt gtctacccag     2400

gaagatgtca tggttccagt ttcggggaat ccttctttct ttgtcgggat tgattttgac     2460

gcccaggaca gcactatctt tttttcagat atgtcaaaac acatgatttt taagcaaaag     2520

attgatggca caggaagaga aattctcgca gctaacaggg tggaaaatgt tgaaagtttg     2580

gcttttgatt ggatttcaaa gaatctctat tggacagact ctcattacaa gagtatcagt     2640

gtcatgaggc tagctgataa aacgagacgc acagtagttc agtatttaaa taacccacgg     2700

tcggtggtag ttcatccttt tgccgggtat ctattcttca ctgattggtt ccgtcctgct     2760

aaaattatga gagcatggag tgacggatct cacctcttgc ctgtaataaa cactactctt     2820

ggatggccca atggcttggc catcgattgg gctgcttcac gattgtactg ggtagatgcc     2880

tattttgata aaattgagca cagcaccttt gatggtttag acagaagaag actgggccat     2940

atagagcaga tgacacatcc gtttggactt gccatctttg gagagcattt attttttact     3000

gactggagac tgggtgccat tattcgagtc aggaaagcag atggtggaga aatgacagtt     3060

atccgaagtg gcattgctta catactgcat ttgaaatcgt atgatgtcaa catccagact     3120

ggttctaacg cctgtaatca acccacgcat cctaacggtg actgcagcca cttctgcttc     3180

ccggtgccaa atttccagcg agtgtgtggg tgcccttatg gaatgaggct ggcttccaat     3240

cacttgacat gcgaggggga cccaaccaat gaaccaccca cagagcagtg tggcttattt     3300

tccttcccct gtaaaaatgg cagatgtgtg cccaattact atctctgtga tggagtcgat     3360

gattgtcatg ataacagtga tgagcaacta tgtggcacac ttaataatac ctgttcatct     3420

tcggcgttca cctgtggcca tggggagtgc attcctgcac actggcgctg tgacaaacgc     3480

aacgactgtg tggatggcag tgatgagcac aactgcccca cccacgcacc tgcttcctgc     3540

cttgacaccc aatacacctg tgataatcac cagtgtatct caaagaactg ggtctgtgac     3600

acagacaatg attgtgggga tggatctgat gaaaagaact gcaattcgac agagacatgc     3660

caacctagtc agtttaattg ccccaatcat cgatgtattg acctatcgtt tgtctgtgat     3720

ggtgacaagg attgtgttga tggatctgat gaggttggtt gtgtattaaa ctgtactgct     3780

tctcaattca agtgtgccag tggggataaa tgtattggcg tcacaaatcg ttgtgatggt     3840

gtttttgatt gcagtgacaa ctcggatgaa gcaggctgtc caaccaggcc tcctggtatg     3900

tgccactcag atgaatttca gtgccaagaa gatggtatct gcatcccgaa cttctgggaa     3960

tgtgatgggc atccagactg cctctatgga tctgatgagc acaatgcctg tgtccccaag     4020

acttgccctt catcatattt ccactgtgac aacggaaact gcatccacag ggcatggctc     4080

tgtgatcggg acaatgactg cggggatatg agtgatgaga aggactgccc tactcagccc     4140

tttcgctgtc ctagttggca atggcagtgt cttggccata acatctgtgt gaatctgagt     4200

gtagtgtgtg atggcatctt tgactgcccc aatgggacag atgagtcccc actttgcaat     4260

gggaacagct gctcagattt caatggtggt tgtactcacg agtgtgttca agagcccttt     4320

ggggctaaat gcctatgtcc attgggattc ttacttgcca atgattctaa gacctgtgaa     4380

gacatagatg aatgtgatat tctaggctct tgtagccagc actgttacaa tatgagaggt     4440

tctttccggt gctcgtgtga tacaggctac atgttagaaa gtgatgggag gacttgcaaa     4500

gttacagcat ctgagagtct gctgttactt gtggcaagtc agaacaaaat tattgccgac     4560

agtgtcacct cccaggtcca caatatctat tcattggtcg agaatggttc ttacattgta     4620

gctgttgatt ttgattcaat tagtggtcgt atcttttggt ctgatgcaac tcagggtaaa     4680

acctggagtg cgtttcaaaa tggaacggac agaagagtgg tatttgacag tagcatcatc     4740

ttgactgaaa ctattgcaat agattgggta ggtcgtaatc tttactggac agactatgct     4800

ctggaaacaa ttgaagtctc caaaattgat gggagccaca ggactgtgct gattagtaaa     4860

aacctaacaa atccaagagg actagcatta gatcccagaa tgaatgagca tctactgttc     4920

tggtctgact ggggccacca ccctcgcatc gagcgagcca gcatggacgg cagcatgcgc     4980

actgtcattg tccaggacaa gatcttctgg ccctgcggct taactattga ctaccccaac     5040

agactgctct acttcatgga ctcctatctt gattacatgg acttttgtga ttataatgga     5100

caccatcgga gacaggtgat agccagtgat ttgattatac ggcaccccta tgccctaact     5160

ctctttgaag actctgtgta ctggactgac cgtgctactc gtcgggttat gcgagccaac     5220

aagtggcatg gagggaacca gtcagttgta atgtataata ttcaatggcc ccttgggatt     5280

gttgcggttc atccttcgaa acaaccaaat tccgtgaatc catgtgcctt ttcccgctgc     5340

agccatctct gcctgctttc ctcacagggg cctcattttt actcctgtgt ttgtccttca     5400

ggatggagtc tgtctcctga tctcctgaat tgcttgagag atgatcaacc tttcttaata     5460

actgtaaggc aacatataat ttttggaatc tcccttaatc ctgaggtgaa gagcaatgat     5520

gctatggtcc ccatagcagg gatacagaat ggtttagatg ttgaatttga tgatgctgag     5580

caatacatct attgggttga aaatccaggt gaaattcaca gagtgaagac agatggcacc     5640

aacaggacag tatttgcttc tatatctatg gtggggcctt ctatgaacct ggccttagat     5700

tggatttcaa gaaaccttta ttctaccaat cctagaactc agtcaatcga ggttttgaca     5760

ctccacggag atatcagata cagaaaaaca ttgattgcca atgatgggac agctcttgga     5820

gttggctttc caattggcat aactgttgat cctgctcgtg ggaagctgta ctggtcagac     5880

caaggaactg acagtggggt tcctgccaag atcgccagtg ctaacatgga tggcacatct     5940

gtgaaaactc tctttactgg gaacctcgaa cacctggagt gtgtcactct tgacatcgaa     6000

gagcagaaac tctactgggc agtcactgga agaggagtga ttgaaagagg aaacgtggat     6060

ggaacagatc gaatgatcct ggtacaccag ctttcccacc cctggggaat tgcagtccat     6120

gattctttcc tttattatac tgatgaacag tatgaggtca ttgaaagagt tgataaggcc     6180

actggggcca acaaaatagt cttgagagat aatgttccaa atctgagggg tcttcaagtt     6240

tatcacagac gcaatgccgc cgaatcctca aatggctgta gcaacaacat gaatgcctgt     6300

cagcagattt gcctgcctgt accaggagga ttgttttcct gcgcctgtgc cactggattt     6360

aaactcaatc ctgataatcg gtcctgctct ccatataact ctttcattgt tgtttcaatg     6420

ctgtctgcaa tcagaggctt tagcttggaa ttgtcagatc attcagaaac catggtgccg     6480

gtggcaggcc aaggacgaaa cgcactgcat gtggatgtgg atgtgtcctc tggctttatt     6540

tattggtgtg attttagcag ctcagtggca tctgataatg cgatccgtag aattaaacca     6600

gatggatctt ctctgatgaa cattgtgaca catggaatag gagaaaatgg agtccggggt     6660

attgcagtgg attgggtagc aggaaatctt tatttcacca atgcctttgt ttctgaaaca     6720

ctgatagaag ttctgcggat caatactact taccgccgtg ttcttcttaa agtcacagtg     6780

gacatgccta ggcatattgt tgtagatccc aagaacagat acctcttctg ggctgactat     6840

gggcagagac caaagattga gcgttctttc cttgactgta ccaatcgaac agtgcttgtg     6900

tcagagggca ttgtcacacc acggggcttg gcagtggacc gaagtgatgg ctacgtttat     6960

tgggttgatg attctttaga tataattgca aggattcgta tcaatggaga gaactctgaa     7020

gtgattcgtt atggcagtcg ttacccaact ccttatggca tcactgtttt tgaaaattct     7080

atcatatggg tagataggaa tttgaaaaag atcttccaag ccagcaagga accagagaac     7140

acagagccac ccacagtgat aagagacaat atcaactggc taagagatgt gaccatcttt     7200

gacaagcaag tccagccccg gtcaccagca gaggtcaaca acaacccttg cttggaaaac     7260

aatggtgggt gctctcatct ctgctttgct ctgcctggat tgcacacccc aaaatgtgac     7320

tgtgcctttg ggaccctgca aagtgatggc aagaattgtg ccatttcaac agaaaatttc     7380

ctcatctttg ccttgtctaa ttccttgaga agcttacact tggaccctga aaaccatagc     7440

ccacctttcc aaacaataaa tgtggaaaga actgtcatgt ctctagacta tgacagtgta     7500

agtgatagaa tctacttcac acaaaattta gcctctggag ttggacagat ttcctatgcc     7560

accctgtctt cagggatcca tactccaact gtcattgctt caggtatagg gactgctgat     7620

ggcattgcct ttgactggat tactagaaga atttattaca gtgactacct caaccagatg     7680

attaattcca tggctgaaga tgggtctaac cgcactgtga tagcccgcgt tccaaaacca     7740

agagcaattg tgttagatcc ctgccaaggg tacctgtact gggctgactg ggatacacat     7800

gccaaaatcg agagagccac attgggagga aacttccgcg tacccattgt gaacagcagt     7860

ctggtcatgc ccagtgggct gactctggac tatgaagagg accttctcta ctgggtggat     7920

gctagtctgc agaggattga acgcagcact ctgacgggcg tggatcgtga agtcattgtc     7980

aatgcagccg ttcatgcttt tggcttgact ctctatggcc agtatattta ctggactgac     8040

ttgtacacac aaagaattta ccgagctaac aaatatgacg ggtcaggtca gattgcaatg     8100

accacaaatt tgctctccca gcccagggga atcaacactg ttgtgaagaa ccagaaacaa     8160

cagtgtaaca atccttgtga acagtttaat gggggctgca gccatatctg tgcaccaggt     8220

ccaaatggtg ccgagtgcca gtgtccacat gagggcaact ggtatttggc caacaacagg     8280

aagcactgca ttgtggacaa tggtgaacga tgtggtgcat cttccttcac ctgctccaat     8340

gggcgctgca tctcggaaga gtggaagtgt gataatgaca acgactgtgg ggatggcagt     8400

gatgagatgg aaagtgtctg tgcacttcac acctgctcac cgacagcctt cacctgtgcc     8460

aatgggcgat gtgtccaata ctcttaccgc tgtgattact acaatgactg tggtgatggc     8520

agtgatgagg cagggtgcct gttcagggac tgcaatgcca ccacggagtt tatgtgcaat     8580

aacagaaggt gcatacctcg tgagtttatc tgcaatggtg tagacaactg ccatgataat     8640

aacacttcag atgagaaaaa ttgccctgat cgcacttgcc agtctggata cacaaaatgt     8700

cataattcaa atatttgtat tcctcgcgtt tatttgtgtg acggagacaa tgactgtgga     8760

gataacagtg atgaaaaccc tacttattgc accactcaca cgtgcagcag cagtgagttc     8820

caatgcgcat ctgggcgctg tattcctcaa cattggtatt gtgatcaaga aacagattgt     8880

tttgatgcct ctgatgaacc tgcctcttgt ggtcactctg agcgaacatg cctagctgat     8940

gagttcaagt gtgatggtgg gaggtgcatc ccaagcgaat ggatctgtga cggtgataat     9000

gactgtgggg atatgagtga cgaggataaa aggcaccagt gtcagaatca aaactgctcg     9060

gattccgagt ttctctgtgt aaatgacaga cctccggaca ggaggtgcat tccccagtct     9120

tgggtctgtg atggcgatgt ggattgtact gacggctacg atgagaatca gaattgcacc     9180

aggagaactt gctctgaaaa tgaattcacc tgtggttacg gactgtgtat cccaaagata     9240

ttcaggtgtg accggcacaa tgactgtggt gactatagcg acgagagggg ctgcttatac     9300

cagacttgcc aacagaatca gtttacctgt cagaacgggc gctgcattag taaaaccttc     9360

gtctgtgatg aggataatga ctgtggagac ggatctgatg agctgatgca cctgtgccac     9420

accccagaac ccacgtgtcc acctcacgag ttcaagtgtg acaatgggcg ctgcatcgag     9480

atgatgaaac tctgcaacca cctagatgac tgtttggaca acagcgatga gaaaggctgt     9540

ggcattaatg aatgccatga cccttcaatc agtggctgcg atcacaactg cacagacacc     9600

ttaaccagtt tctattgttc ctgtcgtcct ggttacaagc tcatgtctga caagcggact     9660

tgtgttgata ttgatgaatg cacagagatg ccttttgtct gtagccagaa gtgtgagaat     9720

gtaataggct cctacatctg taagtgtgcc ccaggctacc tccgagaacc agatggaaag     9780

acctgccggc aaaacagtaa catcgaaccc tatctcattt ttagcaaccg ttactatttg     9840

agaaatttaa ctatagatgg ctatttttac tccctcatct tggaaggact ggacaatgtt     9900

gtggcattag attttgaccg agtagagaag agattgtatt ggattgatac acagaggcaa     9960

gtcattgaga gaatgtttct gaataagaca aacaaggaga caatcataaa ccacagacta    10020

ccagctgcag aaagtctggc tgtagactgg gtttccagaa agctctactg gttggatgcc    10080

cgcctggatg gcctctttgt ctctgacctc aatggtggac accgccgcat gctggcccag    10140

cactgtgtgg atgccaacaa caccttctgc tttgataatc ccagaggact tgcccttcac    10200

cctcaatatg ggtacctcta ctgggcagac tggggtcacc gcgcatacat tgggagagta    10260

ggcatggatg gaaccaacaa gtctgtgata atctccacca agttagagtg gcctaatggc    10320

atcaccattg attacaccaa tgatctactc tactgggcag atgcccacct gggttacata    10380

gagtactctg atttggaggg ccaccatcga cacacggtgt atgatggggc actgcctcac    10440

cctttcgcta ttaccatttt tgaagacact atttattgga cagattggaa tacaaggaca    10500

gtggaaaagg gaaacaaata tgatggatca aatagacaga cactggtgaa cacaacacac    10560

agaccatttg acatccatgt gtaccatcca tataggcagc ccattgtgag caatccctgt    10620

ggtaccaaca atggtggctg ttctcatctc tgcctcatca agccaggagg aaaagggttc    10680

acttgcgagt gtccagatga cttccgcacc cttcagctga gtggcagcac ctactgcatg    10740

cccatgtgct ccagcaccca gttcctgtgc gctaacaatg aaaagtgcat tcctatctgg    10800

tggaaatgtg atggacagaa agactgctca gatggctctg atgaactggc cctttgcccg    10860

cagcgcttct gccgactggg acagttccag tgcagtgacg gcaactgcac cagcccgcag    10920

actttatgca atgctcacca aaattgccct gatgggtctg atgaagaccg tcttctttgt    10980

gagaatcacc actgtgactc caatgaatgg cagtgcgcca acaaacgttg catcccagaa    11040

tcctggcagt gtgacacatt taacgactgt gaggataact cagatgaaga cagttcccac    11100

tgtgccagca ggacctgccg gccgggccag tttcggtgtg ctaatggccg ctgcatcccg    11160

caggcctgga agtgtgatgt ggataatgat tgtggagacc actcggatga gcccattgaa    11220

gaatgcatga gctctgccca tctctgtgac aacttcacag aattcagctg caaaacaaat    11280

taccgctgca tcccaaagtg ggccgtgtgc aatggtgtag atgactgcag ggacaacagt    11340

gatgagcaag gctgtgagga gaggacatgc catcctgtgg gggatttccg ctgtaaaaat    11400

caccactgca tccctcttcg ttggcagtgt gatgggcaaa atgactgtgg agataactca    11460

gatgaggaaa actgtgctcc ccgggagtgc acagagagcg agtttcgatg tgtcaatcag    11520

cagtgcattc cctcgcgatg gatctgtgac cattacaacg actgtgggga caactcagat    11580

gaacgggact gtgagatgag gacctgccat cctgaatatt ttcagtgtac aagtggacat    11640

tgtgtacaca gtgaactgaa atgcgatgga tccgctgact gtttggatgc gtctgatgaa    11700

gctgattgtc ccacacgctt tcctgatggt gcatactgcc aggctactat gttcgaatgc    11760

aaaaaccatg tttgtatccc gccatattgg aaatgtgatg gcgatgatga ctgtggcgat    11820

ggttcagatg aagaacttca cctgtgcttg gatgttccct gtaattcacc aaaccgtttc    11880

cggtgtgaca acaatcgctg catttatagt catgaggtgt gcaatggtgt ggatgactgt    11940

ggagatggaa ctgatgagac agaggagcac tgtagaaaac cgacccctaa accttgtaca    12000

gaatatgaat ataagtgtgg caatgggcat tgcattccac atgacaatgt gtgtgatgat    12060

gccgatgact gtggtgactg gtccgatgaa ctgggttgca ataaaggaaa agaaagaaca    12120

tgtgctgaaa atatatgcga gcaaaattgt acccaattaa atgaaggagg atttatctgc    12180

tcctgtacag ctgggttcga aaccaatgtt tttgacagaa cctcctgtct agatatcaat    12240

gaatgtgaac aatttgggac ttgtccccag cactgcagaa ataccaaagg aagttatgag    12300

tgtgtctgtg ctgatggctt cacgtctatg agtgaccgcc ctggaaaacg atgtgcagct    12360

gagggtagct ctcctttgtt gctactgcct gacaatgtcc gaattcgaaa atataatctc    12420

tcatctgaga ggttctcaga gtatcttcaa gatgaggaat atatccaagc tgttgattat    12480

gattgggatc ccaaggacat aggcctcagt gttgtgtatt acactgtgcg aggggagggc    12540

tctaggtttg gtgctatcaa acgtgcctac atccccaact ttgaatccgg ccgcaataat    12600

cttgtgcagg aagttgacct gaaactgaaa tacgtaatgc agccagatgg aatagcagtg    12660

gactgggttg gaaggcatat ttactggtca gatgtcaaga ataaacgcat tgaggtggct    12720

aaacttgatg gaaggtacag aaagtggctg atttccactg acctggacca accagctgct    12780

attgctgtga atcccaaact agggcttatg ttctggactg actggggaaa ggaacctaaa    12840

atcgagtctg cctggatgaa tggagaggac cgcaacatcc tggttttcga ggaccttggt    12900

tggccaactg gcctttctat cgattatttg aacaatgacc gaatctactg gagtgacttc    12960

aaggaggacg ttattgaaac cataaaatat gatgggactg ataggagagt cattgcaaag    13020

gaagcaatga acccttacag cctggacatc tttgaagacc agttatactg gatatctaag    13080

gaaaagggag aagtatggaa acaaaataaa tttgggcaag gaaagaaaga gaaaacgctg    13140

gtagtgaacc cttggctcac tcaagttcga atctttcatc aactcagata caataagtca    13200

gtgcccaacc tttgcaaaca gatctgcagc cacctctgcc ttctgagacc tggaggatac    13260

agctgtgcct gtccccaagg ctccagcttt atagagggga gcaccactga gtgtgatgca    13320

gccatcgaac tgcctatcaa cctgcccccc ccatgcaggt gcatgcacgg aggaaattgc    13380

tattttgatg agactgacct ccccaaatgc aagtgtccta gcggctacac cggaaaatat    13440

tgtgaaatgg cgttttcaaa aggcatctct ccaggaacaa ccgcagtagc tgtgctgttg    13500

acaatcctct tgatcgtcgt aattggagct ctggcaattg caggattctt ccactataga    13560

aggaccggct cccttttgcc tgctctgccc aagctgccaa gcttaagcag tctcgtcaag    13620

ccctctgaaa atgggaatgg ggtgaccttc agatcagggg cagatcttaa catggatatt    13680

ggagtgtctg gttttggacc tgagactgct attgacaggt caatggcaat gagtgaagac    13740

tttgtcatgg aaatggggaa gcagcccata atatttgaaa acccaatgta ctcagccaga    13800

gacagtgctg tcaaagtggt tcagccaatc caggtgactg tatctgaaaa tgtggataat    13860

aagaattatg gaagtcccat aaacccttct gagatagttc cagagacaaa cccaacttca    13920

ccagctgctg atggaactca ggtgacaaaa tggaatctct tcaaacgaaa atctaaacaa    13980

actaccaact ttgaaaatcc aatctatgca cagatggaga acgagcaaaa ggaaagtgtt    14040

gctgcgacac cacctccatc accttcgctc cctgctaagc ctaagcctcc ttcgagaaga    14100

gacccaactc caacctattc tgcaacagaa gacactttta aagacaccgc aaatcttgtt    14160

aaagaagact ctgaagtata gctataccag ctatttaggg aataattaga aacacacttt    14220

tgcacatata ttttttacaa acagatgaaa aaagttaaca ttcagtactt tatgaaaaaa    14280

atatattttt ccctgtttgc ctatagttgg aggtatcctg tgtgtctttt tttacttatg    14340

ccgtctcata tttttacaaa taattatcac aatgtactat atgtatatct ttgcactgaa    14400

gttgtctgaa ggtaatacta taaatatatt gtatatttgt aaattttgga aagattatcc    14460

tgttactgaa tttgctaata aagatgtctg ctgatttggt tggtgatcat tatagtaaat    14520

gatccaacaa gaaaaggaat tgactgggga cctttagccg tgtctaaaga agaggcacca    14580

ctcatatttc ctataaaatt atctaggaaa ggaatccagg ccccgctctt gggtccattt    14640

ttacacatta gcacttaatt aatgttcaat attacatgtc aatttgatta atggctatgt    14700

tgataggggc cactatgtgt tgtatagaca tctggacttg actgtagact cctcagataa    14760

tacagaaggt aggaaaagca attcagtttg gcccttctgt gtgttggcat tgtctaacca    14820

gaactctctg tttcatgtgt gttctctcac tagctgccaa gacaacattt ttatttgtga    14880

tgtctatgag gaaatcccat atcattaagt gccagtgtcc tgcattgagt ttgtggttaa    14940

ttaaatgagc tcttctgctg atggaccctg gagcaatttc tcccctcacc tgacattcaa    15000

ggtggtcacc tgccctagta gttggagctc agtagctgaa tttctgaaac caaatctgtg    15060

tcttcataaa ataaggtgca aaaaaaaaaa ataccagtta agtaaagcct caactgggtt    15120

tttgtttcta tgaaaatatc attataatca ctatttattt cctaagttga acctgaatag    15180

aaagggaaac cattcttatt aagcttttta ttaggccctg tggctaaatg tgtacattta    15240

tattagaatg tactgtacag tccagatctt ttctttaatt cttattggtt tttttttttt    15300

tttttttttt agagatggag tcttgctata ttgccaaggc tgatcttgaa gtcctgggct    15360

caagtgatcc tcccacctca gcctcctgag tggttggggt tacgggcgtg agccactgtg    15420

cctggcttcc agctctcctc ttaaatagtg ggtatagtct gcacaacagg aaccatggca    15480

ggaatataca ctttcccata gcaaatagca tacctgactc tctgtgctaa tattgcacat    15540

ttgttaaaca atgaatgaat ggatggatgg atggatggat gaatgaatga aacatatact    15600

actgattatt ttattccaga gttctcaaaa tatttgttgc tgatattttg agtgctgact    15660

gtaattactt tgattagata aacaactgga aataatgctg ctgaaaaagt tctaataaat    15720

gtgtatttta tcaga                                                     15735


<210>  48
<211>  1664
<212>  DNA
<213>  Homo sapiens

<400>  48
cgcgtattcg cgggccgcgg ggtcgccgcc ggccgcccag gcgcggagcc tctcgggggt       60

cacccggccg ccgggcccgc gggacgcacg gggccgccag gggaggacaa caagcctcag      120

gccctgtccc tgcgccccgc ccggcctccc ccgcggggct gcgcagccca ctcggccatc      180

ctggcctgaa ggggccgccc ccggcctcgc gggaaagcct gagcctcccg ggccttctcg      240

ggccttctcg gactttcccc caggcgtcct ggaccttctt cggccttcct gggcctcctc      300

gggcttcctt gaccctcccc aggccttccc cgaggcctcc aggcccttcc ctgggcctct      360

ccaggctgag ctctccgcga catggccagt gggcctctgg gacccggggc ccggcccacc      420

cgcctccacc ctccattccc accgcctgct cacatcaagc caggagcacc gcccggatga      480

acacgcaggg ttccggacca atacctgggc cattgtgact ctcagaatgc caggcaataa      540

gagatcagaa agctggttcc acttcatctt ggagatggag gaaagcttgc cagaacaact      600

gcacacccca tccactcctc atgttctcag tttgttcttc tctgtgatac aaccagcatc      660

acgagaacag ccagcagcag ctccagcgtg ataaaatttt cactccttga caagtgtaag      720

aagccggaaa actgtgccca gccagaagtt ttgtgtcgcc cctttgagat gctgtctaac      780

ctccacgagc tgcttccgaa tcacctgatg gagacgcttt attcccgcaa gagtgaagag      840

gacaagaaaa aatgtgagaa tcctgaactc tctggcttag aaagaatctt agcaagacat      900

cagttgccaa aagagattaa tctgacccca aagccgaaca gaatgccccc gtggaaaaga      960

aaaatcatca acaatgtaac tgacgggtgg aagaaatgtc acttgttgaa gagaaacacg     1020

aaagagcctc caatgtccac catagttgtc agaaaactta ttcaaaaaaa tgtacccaga     1080

agacacagcc taaggaatac aagcaggaaa ctgagaaacc tgccaacaac agctaaaggg     1140

acacaaacag gaaaatcaca gtgccttctg ggtatatcag aacctacctg aaattcacaa     1200

actctaaaca atgaatgctc aactctgttg tatgaagtag ccacaattac caaccttcct     1260

gcacaaatca aacaagagat atcttaaaat aggaatgatg ctgaaactct acagcttttg     1320

tgtgaaacac atagaagaag aaagtaaaac aggacaaact ccgtgggcag gctccacctg     1380

actagaggat tccaatgaag gactcaaact ggacaccaaa tccacatagt tctgcctggc     1440

agcttcctga acggacgatg acaaacaacc tcagcccatg gtcaatgaat aagcactttg     1500

agaaagttac tatactaata actaacacct tgcaatgaag aaagaataga agcacatcaa     1560

gatcttgaag actccattta caatggctta atgagaagca caaacttctt tagaagtaca     1620

gcaaataaaa gcacagtaac tagtaaactc aaaaaaaaaa aaaa                      1664


<210>  49
<211>  2593
<212>  DNA
<213>  Homo sapiens

<400>  49
agaaccagga caggtgaggt gcaggctggc tttcctctcg cagcgcggtg tggagtcctg       60

tcctgcctca gggcttttcg gagcctggat cctcaaggaa caagtagacc tggccgcggg      120

gagtggggag ggaaggggtg tctattgggc aacagggcgg ggcaaagccc tgaataaagg      180

ggcgcagggc aggcgcaagt ggcagagcct tcgtttgcca agtcgcctcc agaccgcaga      240

catgaaactt gtcttcctcg tcctgctgtt cctcggggcc ctcggactgt gtctggctgg      300

ccgtaggagg agtgttcagt ggtgcgccgt atcccaaccc gaggccacaa aatgcttcca      360

atggcaaagg aatatgagaa aagtgcgtgg ccctcctgtc agctgcataa agagagactc      420

ccccatccag tgtatccagg ccattgcgga aaacagggcc gatgctgtga cccttgatgg      480

tggtttcata tacgaggcag gcctggcccc ctacaaactg cgacctgtag cggcggaagt      540

ctacgggacc gaaagacagc cacgaactca ctattatgcc gtggctgtgg tgaagaaggg      600

cggcagcttt cagctgaacg aactgcaagg tctgaagtcc tgccacacag gccttcgcag      660

gaccgctgga tggaatgtcc ctatagggac acttcgtcca ttcttgaatt ggacgggtcc      720

acctgagccc attgaggcag ctgtggccag gttcttctca gccagctgtg ttcccggtgc      780

agataaagga cagttcccca acctgtgtcg cctgtgtgcg gggacagggg aaaacaaatg      840

tgccttctcc tcccaggaac cgtacttcag ctactctggt gccttcaagt gtctgagaga      900

cggggctgga gacgtggctt ttatcagaga gagcacagtg tttgaggacc tgtcagacga      960

ggctgaaagg gacgagtatg agttactctg cccagacaac actcggaagc cagtggacaa     1020

gttcaaagac tgccatctgg cccgggtccc ttctcatgcc gttgtggcac gaagtgtgaa     1080

tggcaaggag gatgccatct ggaatcttct ccgccaggca caggaaaagt ttggaaagga     1140

caagtcaccg aaattccagc tctttggctc ccctagtggg cagaaagatc tgctgttcaa     1200

ggactctgcc attgggtttt cgagggtgcc cccgaggata gattctgggc tgtaccttgg     1260

ctccggctac ttcactgcca tccagaactt gaggaaaagt gaggaggaag tggctgcccg     1320

gcgtgcgcgg gtcgtgtggt gtgcggtggg cgagcaggag ctgcgcaagt gtaaccagtg     1380

gagtggcttg agcgaaggca gcgtgacctg ctcctcggcc tccaccacag aggactgcat     1440

cgccctggtg ctgaaaggag aagctgatgc catgagtttg gatggaggat atgtgtacac     1500

tgcaggcaaa tgtggtttgg tgcctgtcct ggcagagaac tacaaatccc aacaaagcag     1560

tgaccctgat cctaactgtg tggatagacc tgtggaagga tatcttgctg tggcggtggt     1620

taggagatca gacactagcc ttacctggaa ctctgtgaaa ggcaagaagt cctgccacac     1680

cgccgtggac aggactgcag gctggaatat ccccatgggc ctgctcttca accagacggg     1740

ctcctgcaaa tttgatgaat atttcagtca aagctgtgcc cctgggtctg acccgagatc     1800

taatctctgt gctctgtgta ttggcgacga gcagggtgag aataagtgcg tgcccaacag     1860

caacgagaga tactacggct acactggggc tttccggtgc ctggctgaga atgctggaga     1920

cgttgcattt gtgaaagatg tcactgtctt gcagaacact gatggaaata acaatgaggc     1980

atgggctaag gatttgaagc tggcagactt tgcgctgctg tgcctcgatg gcaaacggaa     2040

gcctgtgact gaggctagaa gctgccatct tgccatggcc ccgaatcatg ccgtggtgtc     2100

tcggatggat aaggtggaac gcctgaaaca ggtgttgctc caccaacagg ctaaatttgg     2160

gagaaatgga tctgactgcc cggacaagtt ttgcttattc cagtctgaaa ccaaaaacct     2220

tctgttcaat gacaacactg agtgtctggc cagactccat ggcaaaacaa catatgaaaa     2280

atatttggga ccacagtatg tcgcaggcat tactaatctg aaaaagtgct caacctcccc     2340

cctcctggaa gcctgtgaat tcctcaggaa gtaaaaccga agaagatggc ccagctcccc     2400

aagaaagcct cagccattca ctgcccccag ctcttctccc caggtgtgtt ggggccttgg     2460

cctcccctgc tgaaggtggg gattgcccat ccatctgctt acaattccct gctgtcgtct     2520

tagcaagaag taaaatgaga aattttgttg atattctctc cttaaaaaaa aaaaaaaaaa     2580

aaaaaaaaaa aaa                                                        2593


<210>  50
<211>  1473
<212>  DNA
<213>  Homo sapiens

<400>  50
ctggttcctc ccctctcaac tgctctggtt cttataaaaa cctcacagcc ttccactaac       60

atcccgtagg agcctctctc cctactgctg ctacacaaga ccctgagact gacctgcagg      120

acgaaaccat gaagagcctg atccttcttg ccatcctggc cgccttagcg gtagtaactt      180

tgtgttatgg agagtggcag aaagaagaaa acttcggctt tgatatcgtt tcagttctct      240

ctctgaactg gcatcgtgcc caggaatcac atgaaagcat ggaatcttat gaacttaatc      300

ccttcattaa caggagaaat gcaaatacct tcatatcccc tcagcagaga tggagagcta      360

aagtccaaga gaggatccga gaacgctcta agcctgtcca cgagctcaat agggaagcct      420

gtgatgacta cagactttgc gaacgctacg ccatggttta tggatacaat gctgcctata      480

atcgctactt caggaagcgc cgagggacca aatgagactg agggaagaaa aaaaatctct      540

ttttttctgg aggctggcac ctgattttgt atccccctgt agcagcatta ctgaaataca      600

taggcttata tacaatgctt ctttcctgta tattctcttg tctggctgca cccctttttc      660

ccgcccccag attgataagt aatgaaagtg cactgcagtg agggtcaaag gagagtcaac      720

atatgtgatt gttccataat aaacttctgg tgtgatactt tcatcttgta aatctgcttt      780

cttttgggaa gatattgaga tatttaaatc atggcccacc ttacccaaaa taggagattc      840

tgttcatctc atatctagta ttaattagaa aaataactac ataaaaagaa ggaagctaag      900

aaggcactca ctcagccata aattctctaa accctctcta ccttggaatc cgtgaatgga      960

atctggtatg ttttttgcag gattttccta ttgtaaattg tggcaaatac agggctccct     1020

tcatttgctt ttcatctctt atgcatcaaa gtcaaaaaca tttctgaatc aagataatct     1080

agaagagaaa aaaggaggaa aaggaaaaga gaaagcagaa gggacaaata aaagcaattg     1140

gcaaaaactg tcaataatag tttatacact taactatatc aataatcaca ttatatgtaa     1200

atagtctaaa caatccaatt attttttact tctacttatg ttatattttt acttctacat     1260

ttgttaaagg ttccacgcta catttttact attcttgctt taaataattt taataatttc     1320

ttttaaagtt tagataataa gaaaatatcc cgggccaggc acagtggcca cacctgtaat     1380

ctcagtagcc atgaccatac caatgcactc cagcctgtga aacagagtga gactctgtct     1440

ctacagaaaa ataaaaaaga aaagaaagaa aag                                  1473


<210>  51
<211>  4986
<212>  DNA
<213>  Homo sapiens

<400>  51
cctttctgag cagctgtgtt tgaagaaagc tagtgggaaa agttccagga ttacatgtca       60

ggaaactaca agaggtagaa acatttgttg atttaccagt gtttttaact tcctgctggg      120

ctgaaaactg cttgtttcgt ggaaaagcaa aacttgacag caaacatcta aaatgaagag      180

ctcccaaact tttgaggaac aaacggaatg cattgtgaac actctactca tggacttctt      240

gagcccaaca ttgcaggttg ccagccggaa cctatgctgt gtagatgaag tagattcagg      300

agagccttgt tcttttgatg tggctatcat tgctggtcgc cttcggatgt tgggtgacca      360

gttcaacgga gaattggaag cttctgccaa aaacgtcatt gcagaaacca ttaagggaca      420

gacaggagct atactccagg acactgtgga atctctcagc aagacctggt gtgctcagga      480

ttccagctta gcttatgaga gagcttttct ggcagtgtca gtgaaacttc ttgagtacat      540

ggctcacatt gctcctgaag tagtgggaca ggtggctatc cccatgacgg gtatgatcaa      600

tgggaaccaa gccatccggg agttcatcca gggccaggga ggttgggaaa atctggagag      660

ctgaagagtt ggagctattc acgagactga acatcacttc cttgttgact gattgggtga      720

ttgattcctg ggaattcaaa caaacaaata aaaaagcact tttttcattt tatcagaact      780

gaacttagct gaataagtta ttttttactg attgttaaag ttgggagcag ctgccagagg      840

cctgcagagt tggtttttgt tttgttttgt tttgtcaact taatgcaaac cacagagatt      900

ttctactttc tgttttcaca tgagttttaa tgaggttctg ttgaagcaaa gacccctaga      960

cacaaagtaa tgacttgtta gtagtggaat tataagcaac agggcaggcc tttgctggag     1020

gtattttgag agaaagggag aacaatggaa actatttctt cagatgtagc cctgtctttt     1080

ggtaagaatt gtgcctacta attttgcaat ttaaaggatt tcaggaagct ttttggttga     1140

aaaatcttgt tttttttttt ttagacgtag tctcactctg tcacccaggc tggagtgcag     1200

tggtgcgatc tcagctcact gcaagctcca cctcccggtt tcactccatt ctcctgcctc     1260

agcctcctga gtagctggga ctacaggagc ccgccatcac gcccggctaa ttttttgtat     1320

ttttagtaga gatgaggttt cgccgtgtta gccaggatgg tctggatctc ctgacctcgt     1380

gattcgcccg ccttggcctc ccaaagtgct gggattacag gcgtgagcca ccacgcccgg     1440

cctaaaatct tgttatttta agttgagcat tttcattcaa aatcatccct aaacttcatg     1500

ttaatttcac ctgagaagga ctattttatg cattttagag gttggaagca aaaaacaaac     1560

aaacaaacaa aaacagttgt ttctactagg aaggtcaaag aaaataaaag ttactccatt     1620

tttactgcca caggatgcag gaagtgctgg cccacatcta ggacagcaag gccaccccag     1680

cttagatgaa gctagctgca taacacaaag ctttaaaagt gtggttcaca caccacttgt     1740

ggaccttatt gaattgctga ttcgcattcc tagagattct gattctgtag gggtaggctg     1800

gagcctagga acctaccttt taaactagtt ccataggtga ttctgatgta catatagagt     1860

gtgacagcca tcactataga gaatagattg ataaattaca acccacgcgt caaatctggc     1920

ttgctgtctt attttgtaaa taaagtttta ttggaataga gcaacattca cttgtttaca     1980

tattgtccat ggccgctttt gtgctacaat ggcagagttg aatgattata gaagaccata     2040

tggctggtta agtccaaaat atttactagc tggcccttta cagaaaaagt tggctgaccc     2100

cttctctaaa tcaacatttc tccttggtaa ctgaaactct attacagtcc tgacaattcc     2160

agcaaacaca gctgtagata gggtttaaac tcaaagatat ttaactcttc tttgggaact     2220

tagtctccat atgtttgtta gttcttgcat aatccacagt ttctctgggt cttcagccaa     2280

tcagagagct ctgtagctcc tgagtagtcc atttctctgg ccctacaagt gagagtgatt     2340

ggaagcaaag cttatgattt gtatgatctt gtatctcaaa atagtcctta atgatctaat     2400

agattagtag gcagtcatca ggtagagact ccaaaaacca gactactttc ctaaatatca     2460

agaagaaagg cattgctaca gtgattcatg aaaagcagca ttaataactt tggctaaagt     2520

ttaacaaagc taaccacttc ccctctatca gccagccatc tatgtatctc ctctaaatgc     2580

agagaagtaa atatgtagtg ctgttaatac atttttgctt tttaaagtta tgctttgtcc     2640

tggcgcagtg gctcatgcct gtaatcccag cactttggga ggccaaggcg ggtggatcac     2700

ctgaggttag gagtttgaga ccagcctggc caacatggtg aaaccctgtc tctgctaaaa     2760

atacaaaaaa ttagccaggc ttggtggcac gtgcctgtaa tgccagctac tcaggaggct     2820

gaggcaggag aatcacttga acctgggagg cggaggttgc tgtgagctga gttcgcgcca     2880

ttgcactcca gcctgggcta caaaagcgaa actgtctaaa aaaaaaaaaa gaaaataaat     2940

aaagttatgc tttttcctct attcctagtt aaatcacaac aagttagtaa tccataaatg     3000

atgtgtcctg tttctcttta gtagaaatta tatttttggc taccagttaa gaaacttgta     3060

ctcctttgtc ccttatgtta ctataaactc aagatgatga gttttgtggt atttgacttc     3120

ataggcaaaa tcaaaatttt tactttgttg ctattctgtt ttatgaaata aacttctgtc     3180

tatgcatttg aactaagttt cagcaaattc aatctaaatt gaataattcc agctcccagt     3240

tttatcctat gttgctcata aaacagttcc aagtatactg cattatcttg agatttgaag     3300

atatggtgcc cacggggatt atactaggca aatgcgttaa gcagctctgg cctaggtgtt     3360

gtgtatttta agagactcta tcttaggaga gcttaagtga ttgggctgca ggaagaagac     3420

attgtaaccc aggaattaaa aatggattca gattgcctga ttttaacact ttagtttcac     3480

cataggctaa ttatgtgaca ttgggcaaga gacataattc ttctgtacct tagtttctac     3540

atttgtaaaa tagagatgat ttggtaactt attaataaga tttttgtgag agataaataa     3600

aacaaataca ttttgtaaag ggtgagtact tggaatattt taaacactgt gccattagca     3660

atttggaatt ctgtgttatg cagttcataa ggttctagct tgactttttt ctctctccat     3720

taaccctgtc tctcacagat gcaaaccact cttaatggct ttactttcac atcaatgtga     3780

gtgattccta aatatgattt atttcccttc tcaattccat acccacagat gcttattatt     3840

tatttatgtg tacctttctt atccccatac tctccctgtt tgcgatacaa ctagctcaaa     3900

acctcagtca tttttacctt gtctctctct ctccagtcca actcacccaa ctagtttttc     3960

tcatttgtta cttcattttt gtcctggttc ttctaccaga tttattagca actgcctgga     4020

ctattaataa agcctcctac ttaggctttc aatagattgt tctgttcctg ctccattcca     4080

gtctgtccta tatactgcca tcagattgat caaagctgtg gtttctttgt ctattatttt     4140

gattcatttt tagatatggt atcattcatt tttaaattta acataccaat gaagattaca     4200

agacttaaac atcttatcag aagggggcat ttatttttta aatcaagaaa taactttcca     4260

aaagcattgc tttgaatgcc attctcttaa agtccttcag tggaactttt gagtgtgatt     4320

agacatgttc attatcttga ttgtagtgat tttatgggtg atgatttcac accaacttat     4380

caaactgcat actttgaaat gtgtagttta ttgtacatca gcactacctt aataaggttg     4440

ttttttttaa aaaaaaaaaa aaaaccttca gctgctccct actgttcatc aaataacagt     4500

ctgatattca aattccccca gtatctggcc ctaactgccc tatatagcct taatcaatca     4560

tgattctcct ctacaatccc aatgctctag tataaccgag ccagtcacta aagctgccct     4620

cctcctactg ttccctatgt ttcatattcc tttttctgag gctctacctg tagacatctt     4680

caagacccaa cccaactgtc atgaagcctt ctccatgaag gctatccata taaccagaat     4740

aagaagtggt ctttgcctcc ttgaactttt gtttgtacca cttttatgtt tcttatccaa     4800

aaaatggcct taagttgtaa ttatctgtat agtcatcttc cccactagga taaaggattg     4860

ctgaatgata caatttgttg tatacttctg taacacccct cctcttcatt atctggcatg     4920

tacatcgata ttaaaaatat tcattaaatg aatgaatagc tgattgactc agaaaaaaaa     4980

aaaaaa                                                                4986


<210>  52
<211>  1105
<212>  DNA
<213>  Homo sapiens

<400>  52
gggacgcgaa cagggaccat gcagggcaac ggcagcgcgc tgcccaacgc ctcccagccc       60

gtgctccgcg gggacggcgc gcggccctcg tggctggcgt ccgccctggc ctgcgtcctc      120

atcttcacca tcgtggtgga catcctgggc aacctcctgg tcatcctgtc ggtgtatcgg      180

aacaagaagc tcaggaacgc aggaaacatc tttgtggtga gcttagcggt ggcagacctg      240

gtggtggcca tttatccgta cccgttggtg ctgatgtcga tatttaacaa cgggtggaac      300

ctgggctatc tgcactgcca agtcagtggg ttcctgatgg gcctgagcgt catcggctcc      360

atattcaaca tcaccggcat cgccatcaac cgctactgct acatctgcca cagtctcaag      420

tacgacaaac tgtacagcag caagaactcc ctctgctacg tgctcctcat atggctcctg      480

acgctggcgg ccgtcctgcc caacctccgt gcagggactc tccagtacga cccgaggatc      540

tactcgtgca ccttcgccca gtccgtcagc tccgcctaca ccatcgccgt ggtggttttc      600

cacttcctcg tccccatgat catagtcatc ttctgttacc tgagaatatg gatcctggtt      660

ctccaggtca gacagagggt gaaacctgac cgcaaaccca aactgaaacc acaggacttc      720

aggaattttg tcaccatgtt tgtggttttt gtcctttttg ccatttgctg ggctcctctg      780

aacttcattg gcctggccgt ggcctctgac cccgccagca tggtgcctag gatcccagag      840

tggctgtttg tggccagtta ctacatggcg tatttcaaca gctgcctcaa tgccattata      900

tacgggctac tgaaccaaaa tttcaggaag gaatacagga gaattatagt ctcgctctgt      960

acagccaggg tgttctttgt ggacagctct aacgacgtgg ccgatagggt taaatggaaa     1020

ccgtctccac tgatgaccaa caataatgta gtaaaggtgg actccgttta aaaaagcacc     1080

acgttccggg tgagatggac acgct                                           1105


<210>  53
<211>  16819
<212>  DNA
<213>  Homo sapiens

<400>  53
ctcttttgtc ctcttcccag gttccctggc cccttcggag aaacgcactt ggttcgggcc       60

agccgcctga ggggacgggc tcacgtctgc tcctcacact gcagctgctg ggccgtggag      120

cttccccagg gagccagggg gacttttgcc gcagccatga agggggcacg ctggaggagg      180

gtcccctggg tgtccctgag ctgcctgtgt ctctgcctcc ttccgcatgt ggtcccagga      240

accacagagg acacattaat aactggaagt aaaactgctg ccccagtcac ctcaacaggc      300

tcaacaacag cgacactaga gggacaatca actgcagctt cttcaaggac ctctaatcag      360

gacatatcag cttcatctca gaaccaccag actaagagca cggagaccac cagcaaagct      420

caaaccgaca ccctcacgca gatgatgaca tcaactcttt tttcttcccc aagtgtacac      480

aatgtgatgg agacagctcc tccagatgaa atgaccacat catttccctc cagtgtcacc      540

aacacactca tgatgacatc aaagactata acaatgacaa cctccacaga ctccactctt      600

ggaaacacag aagagacatc aacagcagga actgaaagtt ctaccccagt gacctcagca      660

gtctcaataa cagctggaca ggaaggacaa tcacgaacaa cttcctggag gacctctatc      720

caagacacat cagcttcttc tcagaaccac tggactcgga gcacgcagac caccagggaa      780

tctcaaacca gcaccctaac acacagaacc acttcaactc cttctttctc tccaagtgta      840

cacaatgtga cagggactgt ttctcagaag acatctcctt caggtgaaac agctacctca      900

tccctctgta gtgtcacaaa cacatccatg atgacatcag agaagataac agtgacaacc      960

tccacaggct ccactcttgg aaacccaggg gagacatcat cagtacctgt tactggaagt     1020

cttatgccag tcacctcagc agccttagta acatttgatc cagaaggaca atcaccagca     1080

actttctcaa ggacttctac tcaggacaca acagcttttt ctaagaacca ccagactcag     1140

agcgtggaga ccaccagagt atctcaaatc aacaccctca acaccctcac accggttaca     1200

acatcaactg ttttatcctc accaagtgga ttcaacccaa gtggaacagt ttctcaggag     1260

acattccctt ctggtgaaac aaccacctca tccccttcca gtgtcagcaa tacattcctg     1320

gtaacatcaa aggtgttcag aatgccaacc tccagagact ctactcttgg aaacacagag     1380

gagacatcac tatctgtaag tggaaccatt tctgcaatca cttccaaagt ttcaaccata     1440

tggtggtcag acactctgtc aacagcactc tcccccagtt ctctacctcc aaaaatatcc     1500

acagctttcc acacccagca gagtgaaggt gcagagacca caggacggcc tcatgagagg     1560

agctcattct ctccaggtgt gtctcaagaa atatttactc tacatgaaac aacaacatgg     1620

ccttcctcat tctccagcaa aggccacaca acttggtcac aaacagaact gccctcaaca     1680

tcaacaggtg ctgccactag gcttgtcaca ggaaatccat ctacagggac agctggcact     1740

attccaaggg tcccctctaa ggtctcagca ataggggaac caggagagcc caccacatac     1800

tcctcccaca gcacaactct cccaaaaaca acaggggcag gcgcccagac acaatggaca     1860

caagaaacgg ggaccactgg agaggctctt ctcagcagcc caagctacag tgtgactcag     1920

atgataaaaa cggccacatc cccatcttct tcacctatgc tggatagaca cacatcccaa     1980

caaattacaa cggcaccatc aacaaatcat tcaacaatac attccacaag cacctctcct     2040

caggaatcac cagctgtttc ccaaaggggt cacactcaag ccccgcagac cacacaagaa     2100

tcacaaacca cgaggtccgt ctcccccatg actgacacca agacagtcac caccccaggt     2160

tcttccttca cagccagtgg gcactcgccc tcagaaattg ttcctcagga cgcacccacc     2220

ataagtgcag caacaacctt tgccccagct cccaccgggg atggtcacac aacccaggcc     2280

ccgaccacag cactgcaggc agcacccagc agccatgatg ccaccctggg gccctcagga     2340

ggcacgtcac tttccaaaac aggtgccctt actctggcca actctgtagt gtcaacacca     2400

gggggcccag aaggacaatg gacatcagcc tctgccagca cctcacctga cacagcagca     2460

gccatgaccc atacccacca ggctgagagc acagaggcct ctggacaaac acagaccagc     2520

gaaccggcct cctcagggtc acgaaccacc tcagcgggca cagctacccc ttcctcatcc     2580

ggggcgagtg gcacaacacc ttcaggaagc gaaggaatat ccacctcagg agagacgaca     2640

aggttttcat caaacccctc cagggacagt cacacaaccc agtcaacaac cgaattgctg     2700

tccgcctcag ccagtcatgg tgccatccca gtaagcacag gaatggcgtc ttcgatcgtc     2760

cccggcacct ttcatcccac cctctctgag gcctccactg cagggagacc gacaggacag     2820

tcaagcccaa cttctcccag tgcctctcct caggagacag ccgccatttc ccggatggcc     2880

cagactcaga ggacaagaac cagcagaggg tctgacacta tcagcctggc gtcccaggca     2940

accgacacct tctcaacagt cccacccaca cctccatcga tcacatccac tgggcttaca     3000

tctccacaaa ccgagaccca cactctgtca ccttcagggt ctggtaaaac cttcaccacg     3060

gccctcatca gcaacgccac ccctcttcct gtcacctacg cttcctcggc atccacaggt     3120

cacaccaccc ctcttcatgt caccgatgct tcctcagtat ccacaggtca cgccacccct     3180

cttcctgtca ccagcccttc ctcagtatcc acaggtcaca ccacccctct tcctgtcacc     3240

gacacttcct cagaatccac aggtcacgtc acccctcttc ctgtcaccag cttttcctca     3300

gcatccacag gtgacagcac ccctcttcct gtcactgaca cttcctcagc atccacaggt     3360

cacgtcaccc ctcttcctgt caccagcctt tcctcagcat ccacaggtga caccacccct     3420

cttcctgtca ctgacacttc ctcagcatcc acaggtcacg ccacctctct tcctgtcacc     3480

gacacttcct cagtatccac aggtcacacc acccctcttc ctgtcaccga cacttcctca     3540

gcatccacag gtcacgccac ctctcttcct gtcaccgaca cttcctcagt atccacaggt     3600

cacaccaccc ctcttcatgt cactgatgct tcctcagcat ccacaggtca ggccacccct     3660

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcact     3720

agcccttcct cagcatccac aggtcacgcc acccctcttc ttgtcaccga cacttcctca     3780

gcatccacag gacacgccac ccctcttcct gtcaccgacg cttcctcagt gtccacagat     3840

cacgccacct ctcttcctgt aaccatccct tccgcagcat ccacaggtca caccacccct     3900

cttcctgtca ccgacacttc ctcagcatcc acaggtcagg ccacctctct tcttgtcacc     3960

gacacttcct cagtatccac aggtgacacc acgcctcttc ctgtcactag cacttcctca     4020

gcatccacag gtcacgtcac tcctcttcat gtcaccagcc cttcctcagc atccacaggt     4080

cacgccaccc ctcttcctgt caccagcctt tcctcagcat ccacaggtga caccatgcct     4140

cttcctgtca ctagcccttc ctcagcatcc acaggtgaca ccacccctct tcctgtcacc     4200

gacgcttcct cagtatccac aggtcacacc acccctcttc atgtcactga tgcttcctca     4260

gcatccacag gtcaggccac ccctcttcct gtcaccagcc tttcctcagt atccacaggt     4320

gacaccacgc ctcttcctgt cactagccct tcctcagcat ccacaggtca cgccacccct     4380

cttcttgtca ccgacacttc ctcagcatcc acaggacacg ccacccctct tcctgtcacc     4440

gacgcttcct cagtgtccac agatcacgcc acctctcttc ctgtaaccat cccttccgca     4500

gcatccacag gtcacaccac ccctcttcct gtcaccgaca cttcctcagc atccacaggt     4560

caggccacct ctcttcttgt caccgacact tcctcagtat ccacaggtga caccacgcct     4620

cttcctgtca ctagcacttc ctcagcatcc acaggtcacg tcactcctct tcatgtcacc     4680

agcccttcct cagcatccac aggtcacgcc acccctcttc ctgtcaccag cctttcctca     4740

gcatccacag gtgacaccat gcctcttcct gtcactagcc cttcctcagc atccacaggt     4800

gacaccaccc ctcttcctgt caccgacgct tcctcagtat ccacaggtca caccacccct     4860

cttcctgtca ccagcccttc ctcagcatct acaggtcaca ccacccctct tcctgtcacc     4920

gacacttcct cagcatccaa aggtgacacc acccctcttc ctgtcaccag cccttcctca     4980

gcatctacag gtcacaccac ccctcttcct gtcaccgaca cttcctcagc atccacaggt     5040

gacaccaccc ctcttcctgt caccaatgct tcctcattat ccacaggtca cgccacccct     5100

cttcatgtca ccagcccttc ctcagcatcc acaggtcacg ccacccctct tcctgtcacc     5160

agcacttcct cagcatccac cggtcacgcc acccctcttc ctgtcaccgg cctttcctca     5220

gctaccacag atgacaccac ccgtcttcct gtcaccgacg tttcctcggc atccacaggt     5280

caggccaccc ctcttcctgt caccagcctt tcctcagtat ccacaggtga caccacgcct     5340

cttcctgtca ctagcccttc ctcagcatcc acaggtcacg ccagccctct tcttgtcact     5400

gacgcttcct cagcatccac aggtcaggcc acccctcttc ctgtcaccga cacttcctca     5460

gtatccacag ctcacgccac cccacttcct gtcaccggcc tttcttcagc ttccacagat     5520

gacaccaccc gtcttcctgt caccgacgtt tcctcggcat ccacaggtca ggccatccct     5580

cttcctgtca ccagcccttc ctcagcatcc acaggtgaca ccacccctct tcctgtcacc     5640

gacgcttcct cagcatccac aggtgacacc acctctcttc ctgtcaccat cccttcctca     5700

gcatcttcag gtcacaccac ctctcttcct gtcaccgacg cttcctcagt gtccacaggt     5760

cacgccacct ctcttcttgt caccgacgct tcctcagtat ccacaggtga caccacccct     5820

cttcctgtca ccgacactaa ctcagcatcc acaggtgaca ccacccctct tcatgtcacc     5880

gacgcttcct cagtatccac aggtcacgcc acctctcttc ctgtcaccag cctttcctca     5940

gcatccacag gtgacaccac gcctcttcct gtcactagcc cttcctcagc atcctcaggt     6000

cacaccaccc ctcttcctgt caccgacgct tcctcagtac ccacaggtca cgccacctct     6060

cttcctgtca ccgacgcttc ctcagtgtcc acaggtcacg ccacccctct tcctgtcacc     6120

gacgcttcct cagtgtccac aggtcatgcc acccctcttc cggtcaccga cacttcctca     6180

gtatctacag gacaggccac ccctcttcct gtcaccagcc tttcctcagc atccactggt     6240

gacaccacgc cgcttcctgt caccgatact tcctcagcat ccacaggtca ggacacccct     6300

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcact     6360

aacccttcct cagcatccac aggtcacgcc acccctcttc ttgtcaccga cgcttcctca     6420

atatccacag gtcacgccac ctctcttctt gtcaccgacg cttcctcagt atccacaggt     6480

cacgccaccg ctcttcatga caccgatgct tcctcattat ccacagggga caccacccct     6540

cttcctgtca ccagcccttc ctcaacatcc acaggtgaca ccacccctct tcctgtcacc     6600

gaaacttcct cagtatccac aggtcacgcc acctctcttc ctgtcaccga cacttcctca     6660

gcatccacag gtcacgccac ctctcttcct gtcaccgaca cttcctcagc atccacaggt     6720

cacgccaccc ctcttcctgt caccgacact tcctcagcat ccacaggtca ggccacccct     6780

cttcctgtca ccagcccttc ctcagcatcc acaggtcacg ccatccctct tcttgtcacc     6840

gacacttcct cagcatccac aggacaggcc acccctcttc ctgtcaccag cctttcctca     6900

gcatccacag gtgacaccac ccctcttcct gtcaccgacg cttcctcagt gtccacaggt     6960

cacgccacct ctcttcctgt caccagcctt tcctcagtat ccacaggtga caccactcct     7020

cttcctgtca ctagcccttc ctcagcatcc acaggtcacg ccacccctct tcatgtcacc     7080

gacgcttcct cagcatccac aggtcacgcc acccctcttc ctgtcaccag cctttcctca     7140

gcatccacag gtgacaccac gcctcttcct gtcactagcc cttcctcagc atccacaggt     7200

cacgccaccc ctcttcatgt caccgacgct tcctcagtat ccacaggtga caccacccct     7260

cttcctgtca ccagctcttc ctcagcatcc tcaggtcaca ccacccctct tcctgtcacc     7320

gacgcttcct cagcatccac aggtgacacc acccctcttc ctgtcaccga cacttcctca     7380

gcatccacag gtcacgccac ccatcttcct gtcaccggcc tttcctcagc ttccacaggt     7440

gacaccaccc gtcttcctgt caccaacgtt tcctcggcat ccacaggtca tgccacccct     7500

cttcctgtca ccagcacttc ctcagcatcc acaggtgaca ccacccctct tcctggcacc     7560

gacacttcct cagtatccac aggtcacacc acccctcttc ttgtcaccga cgcttcgtca     7620

gtatccacag gtgacaccac ccgtcttcct gtcaccagcc cttcctcagc atctacaggt     7680

cacaccaccc ctctacctgt caccgacact ccctcagcat ccacaggtga caccacccct     7740

cttcctgtca ccaatgcttc ctcattatcc acacgtcacg ccacctctct tcatgtcacc     7800

agcccttcct cagcatccac aggtcacgcc acctctcttc ctgtcaccga cacttccgca     7860

gcatccacag gtcacgccac ccctcttcct gtcaccagca cttcctcagc atccacaggt     7920

gacaccaccc ctcttcctgt caccgacact tactcagcat ccacaggtca ggccacccct     7980

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcact     8040

agcccttcct cagcatccac aggtcacgcc actcctcttc ttgtcaccga cgcttcctca     8100

gcatccacag gtcaggccac ccctcttcct gtcaccagcc tttcctcagt atccacaggt     8160

gacaccacgc ctcttcctgt cactagccct tcctcagcat ccaccggtca tgccacctct     8220

cttcctgtca ccgacacttc ctcagcatcc acaggtgaca ccacctctct tcctgtcacc     8280

gacacttcct cagcatacac aggtgacacc acctctcttc ctgtcaccga cacttcctca     8340

tcatccacag gtgacaccac ccctcttctt gtcaccgaga cttcctcagt atccacaggt     8400

gacaccaccc ctcttcctgt caccgacact tcctcagcat ccacaggtca cgccacccct     8460

cttcctgtca ccaacacttc ctcagtatcc acaggtcacg ccacccctct tcatgtcacc     8520

agcccttcct cagcatccac aggtcacacc acccctcttc ctgtcaccga cgcttcgtca     8580

gtgtccacag gtcacgccac ctctcttcct gtcaccgacg cttcctcagt gttcacaggt     8640

catgccacct ctcttcctgt caccatccct tcctcagcat cctcaggtca caccacccct     8700

cttcctgtca ccgacgcttc ctcagtgtcc acaggtcacg ccacctctct tcctgtcacc     8760

gacgcttcct cagtgtccac aggtcatgcc acccctcttc ctgtcaccga cgcttcctca     8820

gtgtccacag gtcacgctac ccctcttcct ctcaccagcc tttcctcagt atccacaggt     8880

gacaccacgc ctcttcctgt caccgacact tcctcagcat ccacaggtca ggccacccct     8940

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacccctct tcctgtcacc     9000

gacacttcct cagcatccac aggtcacgcc acctctcttc ctgtcaccga cacttcctca     9060

gcatccacag gtcacgccac ccctcttcct gacaccgaca cttcctcagc atccacaggt     9120

cacgccaccc ttcttcctgt caccgacact tcctcagcat ccataggtca cgccacctct     9180

cttcctgtca ccgacacttc ctcaatatcc acaggtcacg ccacccctct tcatgtcacc     9240

agcccttcct cagcatccac cggtcacgcc accccgcttc ctgtcaccga cacttcctca     9300

gcatccacag gtcacgccaa ccctcttcat gtcaccagcc cttcctcagc atccaccggt     9360

cacgccaccc cgcttcctgt caccgacact tcctcagcat ccacaggtca cgccacccct     9420

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcact     9480

agcccttcct cagcatccac aggtcacacc acccctcttc ctgtcaccga cacttcctca     9540

gcatccacag gtcaggccac cgctcttcct gtcaccagca cttcctcagc atccacaggt     9600

gacaccaccc ctcttcctgt caccgacact tcctcagcat ccacaggtca ggccacccct     9660

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcact     9720

agcccttcct cagcatccac aggtcacgcc actcctcttc ttgtcaccga cgcttcctca     9780

gcatccacag gtcaggccac ccctcttcct gtcaccagcc tttcctcagt atccacaggt     9840

gacaccacgc ctcttcctgt cactagccct tcctcagcat ccaccggtca tgccacctct     9900

cttcctgtca ccgacacttc ctcagcatcc acaggtgaca ccacctctct tcctgtcacc     9960

gacacttcct cagcatacac aggtgacacc acctctcttc ctgtcaccga cacttcctca    10020

tcatccacag gtgacaccac ccctcttctt gtcaccgaga cttcctcagt atccacaggt    10080

cacgccactc ctcttcttgt caccgacgct tcctcagcat ccacaggtca cgccacccct    10140

cttcatgtca ccagcccttc ctcagcatcc acaggtgaca ccacccctgt gcctgtcacc    10200

gacacttcct cagtatccac aggtcacgcc acccctcttc ctgtcaccgg cctttcctca    10260

gcttccacag gtgacaccac ccgtcttcct gtcaccgaca tttcctcggc atccacaggt    10320

caggccaccc ctcttcctgt caccaacact tcctcagtat ccacaggtga caccatgcct    10380

cttcctgtca ctagcccttc ctcagcatcc acaggtcacg ccacccctct tcctgtcacc    10440

agcacttcct cagcatccac cggtcacgcc acccctgttc ctgtcaccag cacttcctca    10500

gcatctacag gtcacaccac ccctcttcct gtcaccgaca cttcctcagc atccacaggt    10560

gacaccaccc ctcttcctgt caccagccct tcctcagcat ctacaggtca caccacccct    10620

cttcatgtca ccatcccttc ctcagcatcc acaggtgaca ccagcactct tcctgtcacc    10680

ggcgcttcct cagcatccac cggtcacgcc acccctcttc ctgtcaccga cacttcctca    10740

gtatccaccg gtcacgccac gcctcttcct gtcaccagcc tttcctcagt atccacaggt    10800

gacaccaccc ctcttcctgt caccgacgct tcctcggcat ccacaggtca ggccacccct    10860

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacccctct tcttgtcacc    10920

gacgcttcct cagtatccac aggtcacgcc acccctcttc ctgtcaccga cacttcctca    10980

gcatccacag gtgacaccac ccgtcttcct gtcacggaca cttcctcagc atccacaggt    11040

caggccaccc ctcttcctgt caccagcctt tcctcagtat ccacaggtga caccacccct    11100

cttcttgtca ccgacgcttc ctcagtatcc acaggtcacg ccacccctct tcctgtcacc    11160

gacacttcct cagcatccac aggtgacacc acccgtcttc ctgtcacgga cacttcctca    11220

gcatccacag gtcaggccac ccctcttcct gtcaccatcc cttcctcatc atcctcaggt    11280

cacaccaccc ctcttcctgt caccagcact tcctcagtat ctacaggtca cgtcacccct    11340

cttcatgtca ccagcccttc ctcagcatcc acaggtcacg tcacccctct tcctgtcacc    11400

agcacttcct cagcatccac aggtcacgcc acccctcttc ttgtcaccga cgcttcctca    11460

gtgtccacag gtcacgccac gcctcttcct gtcaccgacg cttcctcagc atccacaggt    11520

gacaccaccc ctcttcctgt caccgacact tcctcagcat ccacaggtca ggccacccct    11580

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacccctct tcctgtcacc    11640

gacgcttcct cagcatccac aggtcacgcc acccctcttc ctgtcaccat cccttcctca    11700

gtatccacag gtgacaccat gcctcttcct gtcactagcc cttcctcagc atccacaggt    11760

cacgccaccc ctcttcctgt taccggcctt tcctcagctt ccacaggtga caccacccct    11820

cttcctgtca ccgacacttc ctcagcatcc acacgtcacg ccacccctct tcctgtcacc    11880

gacacttcct cagcttccac agatgacacc acccgtcttc ctgtcaccga cgtttcctcg    11940

gcatccacag gacatgccac ccctcttcct gtcaccagca cttcctcagc atccacaggt    12000

gacaccaccc ctcttcctgt caccgacact tcctcagtat ccacaggtca cgccacctct    12060

cttcctgtca ccagccgttc ctcagcatcc acaggtcacg ccacccccct tcctgtcacc    12120

gacacttcct cagtatccac aggtcacgcc acccctcttc ctgtcaccag cacttcctca    12180

gtatctacag gtcacgccac ccctcttcct gtcaccagcc cttcctcagc atccacaggt    12240

cacgccaccc ctgttcctgt caccagcact tcctcagcat ccacaggtga caccacccct    12300

cttcctgtca ccaatgcttc ctcattatcc acaggtcacg ccacccctct tcatgtcacc    12360

agcccttcct cagcatccag aggtgacacc agcactcttc ctgtcaccga tgcttcctca    12420

gcatccaccg gtcacgccac ccctcttcct ctcaccagcc tttcctcagt atccacaggt    12480

gacaccacgc ctcttcctgt caccgacact tcctctgcat ccacaggtca ggccacccct    12540

cttcctgtca ccagcctttc ctcagtatcc acaggtgaca ccacgcctct tcctgtcacc    12600

atcccttcct cagcatcctc aggtcacacc acctctcttc ctgtcaccga cgcttcctca    12660

gtgtccacag gtcacggcac ccctcttcct gtcaccagca cttcctcagc atccacaggt    12720

gacaccaccc ctcttcctgt caccgacact tcctcagcat ccacaggtca cgccacccct    12780

cttcctgtca ccgacacttc ctcagcatcc acaggtcacg ccacccctct tcctgtcacc    12840

agcctttcct cagtatccac aggtcacgcc acccctcttg ctgtcagcag tgctacctca    12900

gcttccacag tatcctcgga ctcccctctg aagatggaaa caccaggaat gacaacaccg    12960

tcactgaaga cagacggtgg gagacgcaca gccacatcac caccccccac aacctcccag    13020

accatcattt ccaccattcc cagcactgcc atgcacaccc gctccacagc tgcccccatc    13080

cccatcctgc ctgagagagg agtttccctc ttcccctatg gggcaggcgc cggggacctg    13140

gagttcgtca ggaggaccgt ggacttcacc tccccactct tcaagccggc gactggcttc    13200

ccccttggct cctctctccg tgattccctc tacttcacag acaatggcca gatcatcttc    13260

ccagagtcag actaccagat tttctcctac cccaacccac tcccaacagg cttcacaggc    13320

cgggaccctg tggccctggt ggctccgttc tgggacgatg ctgacttctc cactggtcgg    13380

gggaccacat tttatcagga atacgagacg ttctatggtg aacacagcct gctagtccag    13440

caggccgagt cttggattag aaagatgaca aacaacgggg gctacaaggc caggtgggcc    13500

ctaaaggtca cgtgggtcaa tgcccacgcc tatcctgccc agtggaccct cgggagcaac    13560

acctaccaag ccatcctctc cacggacggg agcaggtcct atgccctgtt tctctaccag    13620

agcggtggga tgcagtggga cgtggcccag cgctcaggca acccggtgct catgggcttc    13680

tctagtggag atggctattt cgaaaacagc ccactgatgt cccagccagt gtgggagagg    13740

tatcgccctg atagattcct gaattccaac tcaggcctcc aagggctgca gttctacagg    13800

ctacaccggg aagaaaggcc caactaccgt ctcgagtgcc tgcagtggct gaagagccag    13860

cctcggtggc ccagctgggg ctggaaccag gtctcctgcc cttgttcctg gcagcaggga    13920

cgacgggact tacgattcca acccgtcagc ataggtcgct ggggcctcgg cagtaggcag    13980

ctgtgcagct tcacctcttg gcgaggaggc gtgtgctgca gctacgggcc ctggggagag    14040

tttcgtgaag gctggcacgt gcagcgtcct tggcagttgg cccaggaact ggagccacag    14100

agctggtgct gccgctggaa tgacaagccc tacctctgtg ccctgtacca gcagaggcgg    14160

ccccacgtgg gctgtgctac atacaggccc ccacagcccg cctggatgtt cggggacccc    14220

cacatcacca ccttggatgg tgtcagttac accttcaatg ggctggggga cttcctgctg    14280

gtcggggccc aagacgggaa ctcctccttc ctgcttcagg gccgcaccgc ccagactggc    14340

tcagcccagg ccaccaactt catcgccttt gcggctcagt accgctccag cagcctgggc    14400

cccgtcacgg tccaatggct ccttgagcct cacgacgcaa tccgtgtcct gctggataac    14460

cagactgtga catttcagcc tgaccatgaa gacggcggag gccaggagac gttcaacgcc    14520

accggagtcc tcctgagccg caacggctct gaggtctcgg ccagcttcga cggctgggcc    14580

accgtctcgg tgatcgcgct ctccaacatc ctccacgcct ccgccagcct cccgcccgag    14640

taccagaacc gcacggaggg gctcctgggg gtctggaata acaatccaga ggacgacttc    14700

aggatgccca atggctccac cattccccca gggagccctg aggagatgct tttccacttt    14760

ggaatgacct ggcagatcaa cgggacaggc ctccttggca agaggaatga ccagctgcct    14820

tccaacttca cccctgtttt ctactcacaa ctgcaaaaaa acagctcctg ggctgaacat    14880

ttgatctcca actgtgacgg agatagctca tgcatctatg acaccctggc cctgcgcaac    14940

gcaagcatcg gacttcacac gagggaagtc agtaaaaact acgagcaggc gaacgccacc    15000

ctcaatcagt acccgccctc catcaatggt ggtcgtgtga ttgaagccta caaggggcag    15060

accacgctga ttcagtacac cagcaatgct gaggatgcca acttcacgct cagagacagc    15120

tgcaccgact tggagctctt tgagaatggg acgttgctgt ggacacccaa gtcgctggag    15180

ccattcactc tggagattct agcaagaagt gccaagattg gcttggcatc tgcactccag    15240

cccaggactg tggtctgcca ttgcaatgca gagagccagt gtttgtacaa tcagaccagc    15300

agggtgggca actcctccct ggaggtggct ggctgcaagt gtgacggggg caccttcggc    15360

cgctactgcg agggctccga ggatgcctgt gaggagccgt gcttcccgag tgtccactgc    15420

gttcctggga agggctgcga ggcctgccct ccaaacctga ctggggatgg gcggcactgt    15480

gcggctctgg ggagctcttt cctgtgtcag aaccagtcct gccctgtgaa ttactgctac    15540

aatcaaggcc actgctacat ctcccagact ctgggctgtc agcccatgtg cacctgcccc    15600

ccagccttca ctgacagccg ctgcttcctg gctgggaaca acttcagtcc aactgtcaac    15660

ctagaacttc ccttaagagt catccagctc ttgctcagtg aagaggaaaa tgcctccatg    15720

gcagaagtca acgcctcggt ggcatacaga ctggggaccc tggacatgcg ggcctttctc    15780

cgcaacagcc aagtggaacg aatcgattct gcagcaccgg cctcgggaag ccccatccaa    15840

cactggatgg tcatctcgga gttccagtac cgccctcggg gcccggtcat tgacttcctg    15900

aacaaccagc tgctggccgc ggtggtggag gcgttcttat accacgttcc acggaggagt    15960

gaggagccca ggaacgacgt ggtcttccag cccatctccg gggaagacgt gcgcgatgtg    16020

acagccctga acgtgagcac gctgaaggct tacttcagat gcgatggcta caagggctac    16080

gacctggtct acagccccca gagcggcttc acctgcgtgt ccccgtgcag taggggctac    16140

tgtgaccatg gaggccagtg ccagcacctg cccagtgggc cccgctgcag ctgtgtgtcc    16200

ttctccatct acacggcctg gggcgagcac tgtgagcacc tgagcatgaa actcgacgcg    16260

ttcttcggca tcttctttgg ggccctgggc ggcctcttgc tgctgggggt cgggacgttc    16320

gtggtcctgc gcttctgggg ttgctccggg gccaggttct cctatttcct gaactcagct    16380

gaggccttgc cttgaagggg cagctgtggc ctaggctacc tcaagactca cctcatcctt    16440

accgcacatt taaggcgcca ttgcttttgg gagactggaa aagggaaggt gactgaaggc    16500

tgtcaggatt cttcaaggag aatgaatact gggaatcaag acaagactat accttatcca    16560

taggcgcagg tgcacagggg gaggccataa agatcaaaca tgcatggatg ggtcctcacg    16620

cagacacacc cacagaagga cactagcctg tgcacgcgcg cgtgcacaca cacacacaca    16680

cacacgagtt cataatgtgg tgatggccct aagttaagca aaatgcttct gcacacaaaa    16740

ctctctggtt tacttcaaat taactctatt taaataaagt ctctctgact ttttgtgtct    16800

ccaaaaaaaa aaaaaaaaa                                                 16819


<210>  54
<211>  7450
<212>  DNA
<213>  Homo sapiens

<400>  54
atgagatcaa atgcgaggga gatgcaccgt caattacaaa cacttggaca agtctaactt       60

tttttttctt ctacaaaaac gctttcaaaa gcaaccttag caacgcccaa ataagaagcc      120

acctctaagc aaaatagtat atgtataaac ggagggcgaa tatatacaag tatatatata      180

tgtatattac agacgcacag gtttacaccc ggtgaacttt ttctttttct ttttcttttt      240

tttttaagaa aaactagtga cattgcagag aaggacgctt cctctctatc ttttggcgca      300

ttagtgaagg gggtattcta ttttgttaaa gcgcccaagg gggcgcaggg accttggaga      360

gaagagtggg gaggaaagag gaagggtggg tggggggcag agggcgagtc ggcggcggcg      420

agggcaagct ctttcttgcg gcacgatgcc gtctctgctg gtgctcactt tctccccgtg      480

cgtactactc ggctgggcgt tgctggccgg cggcaccggt ggcggtggcg ttggcggcgg      540

cggcggtggc gcgggcatag gcggcggacg ccaggagaga gaggcgctgc cgccacagaa      600

gatcgaggtg ctggtgttac tgccccagga tgactcgtac ttgttttcac tcacccgggt      660

gcggccggcc atcgagtatg ctctgcgcag cgtggagggc aacgggactg ggaggcggct      720

tctgccgccg ggcactcgct tccaggtggc ttacgaggat tcagactgtg ggaaccgtgc      780

gctcttcagc ttggtggacc gcgtggcggc ggcgcggggc gccaagccag accttatcct      840

ggggccagtg tgcgagtatg cagcagcgcc agtggcccgg cttgcatcgc actgggacct      900

gcccatgctg tcggctgggg cgctggccgc tggcttccag cacaaggact ctgagtactc      960

gcacctcacg cgcgtggcgc ccgcctacgc caagatgggc gagatgatgc tcgccctgtt     1020

ccgccaccac cactggagcc gcgctgcact ggtctacagc gacgacaagc tggagcggaa     1080

ctgctacttc accctcgagg gggtccacga ggtcttccag gaggagggtt tgcacacgtc     1140

catctacagt ttcgacgaga ccaaagactt ggatctggaa gacatcgtgc gcaatatcca     1200

ggccagtgag agagtggtga tcatgtgtgc gagcagtgac accatccgga gcatcatgct     1260

ggtggcgcac aggcatggca tgaccagtgg agactacgcc ttcttcaaca ttgagctctt     1320

caacagctct tcctatggag atggctcatg gaagagagga gacaaacacg actttgaagc     1380

taagcaagca tactcgtccc tccagacagt cactctactg aggacagtga aacctgagtt     1440

tgagaagttt tccatggagg tgaaaagttc agttgagaaa caagggctca atatggagga     1500

ttacgttaac atgtttgttg aaggattcca cgatgccatc ctcctctacg tcttggctct     1560

acatgaagta ctcagagctg gttacagcaa aaaggatgga gggaaaatta tacagcagac     1620

ttggaacaga acatttgaag gtatcgccgg gcaggtgtcc atagatgcca acggagaccg     1680

atatggggat ttctctgtga ttgccatgac tgatgtggag gcgggcaccc aggaggttat     1740

tggtgattat tttggaaaag aaggtcgttt tgaaatgcgg ccgaatgtca aatatccttg     1800

gggcccttta aaactgagaa tagatgaaaa ccgaattgta gagcatacaa acagctctcc     1860

ctgcaaatca tcaggtggcc tagaagaatc ggcagtgaca ggaattgtcg tgggggcttt     1920

actaggagct ggcttgctaa tggccttcta ctttttcagg aagaaataca gaataaccat     1980

tgagaggcga acccagcaag aagaaagtaa ccttggaaaa catcgggaat tacgggaaga     2040

ttccatcaga tcccattttt cagtagctta aaggaagccc cccacttttt ttttttctgc     2100

ctgagattct ttaaggagat agacgggttg aaagacatca atgaaacaga aggggcgttc     2160

ttgaagaatt cataatttta agcagttagt aatttcattt taaaatttct gtagaagctc     2220

aggaattatg attaatcacc atctgcctcc aggcctttca tctcatgaca aacaaatata     2280

ataatgatat cgtgtcactc tgttaaatgt tcatactgtt tcaagcccat atgattagat     2340

ttatgttttt aaaatctgtt gtctccatat cttgatggct tttgggagca tttcacacaa     2400

ggatataaaa tgcggttttc ttaaatgaaa tgttttgtag ctagaataaa atcattttta     2460

caagtacagc attcttggaa agaatttaac acccaaaaag gggaaaatgt aatgaaaaat     2520

ctcaaggttg gaaatacagc cttactctct ctagagctgg aggacaggtt tgtggttgag     2580

gacttctctg tccgatgtct acattcaggt tctgacttca tatcttgaaa aaggatttcc     2640

tccctgtctt tttcagtgtc tcataaacgc tactctggat tgttgtaaat attagtgaga     2700

tgggaggatt tacagaagaa aagcaagtca aaaatatttc ctttttgatg taaaaaaaaa     2760

aagccctatt tcgcactaac attttatttt acaagtattt taatcttata ttttggtatt     2820

agaaaaattt gtctattttt tcattttgaa gattaaatgt tgcttacatt ttaaaagcat     2880

gggtgaagtg tacaacaaac caataatgat aaaaaatact tctctttttc tccctgtttc     2940

cctttttccc ttggccacag ccaaatgcta attgctgctt taattacaga gatgtgtaaa     3000

tgtattcaga ttacaaactc tacaggaata catcaacatt ttaactcttt tgcgttttta     3060

ctgtttaact gttttaaatg caagttattt tagggtgaca ctccttccag ttctggccag     3120

atcatgagtt tcaagatcaa gagtaaaaag ttattagaat taaacagttt tataaaggga     3180

ggcagccctt ttccctcaag aacaactttg ttgagagtta ctacttgaca gcaagcacag     3240

aaatgacaaa tttaaaactt ttacacatgg catttaccaa aattcccagt gattattttg     3300

tttaaaagag ggaacctaaa tatctactct attccctttc agttaactcc acagaacttt     3360

gtaggcatcc atgaatacct gtaatagtgg gttaggtgtg gagataagga atttggacaa     3420

agttgagtaa gtttttactg ggtatctgct ttgcacccag tagtctgcaa catgagttta     3480

aactcaggtt actactttca cttatacttt atggagaaga tagacagtga gggaggaatg     3540

ggaagctgtc atgagagtgc accgtcttgg aattacataa ctggggtctt tcctcaataa     3600

cattttgagc atctgaaaaa tagtttaaaa aattgtctta atatctatta aaaggcatgt     3660

ctagtgagga aacaggagag tctgagcaat cccttggtgg cgatgaaggt ggtagttcac     3720

acaagtaaca gtggaggcaa aggtaagcgc aagctgcctg tcccagatgc tggcccatgt     3780

gtgagtgctt ccctggagaa gtccgcttct gttgctccca cctgagtcac agttaacaga     3840

ttatttctgt gtgaggcaca tttcccttct gttgtttaag aaatgggagc tgggaggcag     3900

ctgagagggc gtgataaaag aattaagtgt gatcaactga aacaactatg ttgtagttct     3960

ccatgctgga tgcaaaggaa aaagtgtcga attccaaaaa ggatggaaga agaaggcaag     4020

aagggcaaac tccagaagtt ctagtgcagg aagagagttt gagaagtaaa atccaggcaa     4080

gcaaagcgtt gtaccacttg ggactcccca aagtgaaaca gcaaggaagg attgtgtcca     4140

tcttacttac ttgaattgga gagcttgttt ctctctcatt tttatttttc aatgatgttt     4200

tctttatatt ttagagatat tcattttctc ttatcttgtg cttgtaaaaa gcatttacat     4260

ttcaagtcta tgtgcttatt acaggggaaa aataatctac ctggttgcag tctttgagta     4320

taaacatttc taaccttttt aaaacttcta tagcagccca ttaacactaa catttttaga     4380

gcaaatatat tctattttaa cttcaggtag aggaatagtc ctaaacttaa tatgatagct     4440

ctagataaga tcttagagat aagtgagcat ttagtattct aaaagtggca gaacaaatca     4500

tgaggtttct ggatgctata ccaatttaaa atcaattctt atgttaatat tgattgctta     4560

tttacatgtc agtcatctac tttttttctt tgaaatctgc atatgggtta caaaaactct     4620

gttaggtttt gaaaattcca ttaagttgga aaccttggtt aaaaatgtag gtgcctggcc     4680

catggttacc ctggattcag gtctctcatg attatatttg gggatttacg ttcctaactg     4740

ctaagcaaca tctttgacaa ctagtaattc atactctact agtagtcaca tgtcatatag     4800

taaaataaat agggctttag ttcttaagta attctatagg attttaccct gaaatccagg     4860

gtgttcagat ttcaaaaagg ataatttatc agtattttct catccagtca aacttcagct     4920

gacattgata caggtcaaaa tgcgtagatg ctttttggtg ttggaaataa gtgtctgtct     4980

tatggtcatc attgtcttct tagatttttg ggtagggggg ccaggtaggg ggagactcag     5040

aaataaaagc gttccccaga taacttcaat ctggaaagaa ttttttgtat agagtccatc     5100

tctccctcaa gactgaccac aggtttcatg agaaggtccc tgaaaacatc acatttctct     5160

gaagaaccat caacttgtct tttcttgaac cacaggaatg gttctacaga ccctactata     5220

attcttcaca tttcagaacc catgtttaat ggagggaaga gagaaatgca tgggaaaaga     5280

acacctcctt ttctcctttc tcttaaattc aaagacgttt gctttggaat gccctcactt     5340

ctccctattc acaggcttct aaaatcatta atttactcaa ggcacatgtg ccttctttgc     5400

cccaaatgca tcactttcct tttagttatg gctgattttg ggtgtgtgtg tgtaagacat     5460

gcagtcaaca atgagatgaa ggccattgca tagatctcat gcagatagtg atggattcag     5520

aaagtaggtt ccagtggcgt cactaccttc ttgtaagcca gtatacactg gctatttgtg     5580

gaaatctctt tgggagatca aatagagtat tatgccactg tgagtgttta taaactggaa     5640

ggaacaagta cctgtgtttc ttgggacaca aagcactcag atcctgagtg gatgcagaca     5700

tgagagtaaa tgtcagccca aattaggccc ctcgacctac agacatttca tgggttttat     5760

ttaatcacac cccatggttt ggggctacat gaggaagttg gtaatgagct gaatttctta     5820

ttcagtggaa aaaactgaaa ctgtctaaaa acacgggata tattttagag gcaattgtgg     5880

aagcggagag aatgagatga tggtgttcag agggaccagc ttctttttca gttgtcttta     5940

gaactcaaga ataatcaata atttagtgcc ccttcaacag ccatactcag caagaagaat     6000

cagaagcttg atcctctaac agaaatagaa gagggtagct ttgcccattg ccactgtctt     6060

tactgcccct tctgcccctc cacccacatc cacattcagc atcactccaa ggatgtgtca     6120

gcatcttgcc catgcaggta gaaatttgtg agtaggcctc catacttcct cgggggaaga     6180

aagagaaact agtgctggtt ttaagaatgt agctggcttt tcatcagaac ccttatgcta     6240

acctgaccac acttgctctc ggggaagttc aagcctgtga tgtgcataaa ctccaacaag     6300

cctggctttg gtgttcagca tgcacattcc ataaatatct cttgcaggca taccccacag     6360

ctagactgca ggattaaaat aacttccaaa aggtgctgga ttggagtttg ttcaaatttc     6420

tcattaacca ctaatgttaa ttcataccaa atgcaaagta ttctaaacca gctgatgctg     6480

tcagtgttca agttttaagt gacttcaaac acaatggaag tgtttcaatg ggagccagat     6540

ctcatgagta aaaatccatt ttataatagc tctgtgatat atcagtggga gatgattcat     6600

aggggagaga tttgaacaag cagaattaag tgttagcaaa aatgctgcat tgctttgatt     6660

catgtttaaa gacctaaatt tctatgcaca aggaataaag ggcctactta ccaagtgtaa     6720

atcacaacat aggctaccaa aatatttctt atttgctagg agaacaaagc tgtcacggtg     6780

catgatagtt ggacagagat ggctaaaaaa gaggcaaatt cagatttgga aacagggtgg     6840

cctcttcatt atttattgcc aagatctgaa aatcttcaac atcttataag acaacaatga     6900

agtagcccct gaacagcatg gagttgctgt gagtttgttc gttgcagacc tttgtgttgg     6960

gtcctgggaa tctgagcttt gttccctgtg catggtggat aattgaaacc aagaggacat     7020

gggatagacc ttgtgacaga ccaattctgt gacccctgtc ttctgggtca cattattcat     7080

tgttgattta aatacaggac taccaaacag tacaaatcta tcatgagtct ggtagaaaag     7140

taaaagtaaa agctgcacac gttacatact gtttattgtt ctaatgtaca actaactatt     7200

tgcatataat gtgatttaat ttattgctgt tttgtgtaga aaaggagaac taatgactgt     7260

ggatataacc catgttttgt ataatatatt ttatttcttg tgcgaactgg tcatttaaaa     7320

tatctacttc atttgatgtt tggatataaa tgtgtatgtg tccttgtaaa tgtttctatc     7380

aagcaagaat gccacgtact cagagtataa caatgtgttc tcattaaaaa atacatccca     7440

cggaaacctc                                                            7450


<210>  55
<211>  4930
<212>  DNA
<213>  Homo sapiens

<400>  55
ctcagccttc ccggttcggg aaaggggaag aatgcaggag gggtaggatt tctttcctga       60

taggatcggt tgggaaagac cgcagcctgt gtgtgtcttt cccttcgacc aaggtgtctg      120

ttgctccgta aataaaacgt cccactgcct tctgagagcg ctataaaggc agcggaaggg      180

tagtccgcgg ggcattccgg gcggggcgcg agcagagaca ggtcatggca gcgccaggcg      240

gcaggtcgga gccgccgcag ctccccgagt acagctgcag ctacatggtg tcgcggccgg      300

tctacagcga gctcgctttc cagcaacagc acgagcggcg cctgcaggag cgcaagacgc      360

tgcgggagag cctggccaag tgctgcagtt gttcaagaaa gagagccttt ggtgtgctaa      420

agactcttgt gcccatcttg gagtggctcc ccaaataccg agtcaaggaa tggctgctta      480

gtgacgtcat ttcgggagtt agtactgggc tagtggccac gctgcaaggg atggcatatg      540

ccctactagc tgcagttcct gtcggatatg gtctctactc tgcttttttc cctatcctga      600

catactttat ctttggaaca tcaagacata tctcagttgg accttttcca gtggtgagtt      660

taatggtggg atctgttgtt ctgagcatgg cccccgacga acactttctc gtatccagca      720

gcaatggaac tgtattaaat actactatga tagacactgc agctagagat acagctagag      780

tcctgattgc cagtgccctg actctgctgg ttggaattat acagttgata tttggtggct      840

tgcagattgg attcatagtg aggtacttgg cagatccttt ggttggtggc ttcacaacag      900

ctgctgcctt ccaagtgctg gtctcacagc taaagattgt cctcaatgtt tcaaccaaaa      960

actacaatgg agttctctct attatctata cgctggttga gatttttcaa aatattggtg     1020

ataccaatct tgctgatttc actgctggat tgctcaccat tgtcgtctgt atggcagtta     1080

aggaattaaa tgatcggttt agacacaaaa tcccagtccc tattcctata gaagtaattg     1140

tgacgataat tgctactgcc atttcatatg gagccaacct ggaaaaaaat tacaatgctg     1200

gcattgttaa atccatccca agggggtttt tgcctcctga acttccacct gtgagcttgt     1260

tctcggagat gctggctgca tcattttcca tcgctgtggt ggcttatgct attgcagtgt     1320

cagtaggaaa agtatatgcc accaagtatg attacaccat cgatgggaac caggaattca     1380

ttgcctttgg gatcagcaac atcttctcag gattcttctc ttgttttgtg gccaccactg     1440

ctctttcccg cacggccgtc caggagagca ctggaggaaa gacacaggtt gctggcatca     1500

tctctgctgc gattgtgatg atcgccattc ttgccctggg gaagcttctg gaacccttgc     1560

agaagtcggt cttggcagct gttgtaattg ccaacctgaa agggatgttt atgcagctgt     1620

gtgacattcc tcgtctgtgg agacagaata agattgatgc tgttatctgg gtgtttacgt     1680

gtatagtgtc catcattctg gggctggatc tcggtttact agctggcctt atatttggac     1740

tgttgactgt ggtcctgaga gttcagtttc cttcttggaa tggccttgga agcatcccta     1800

gcacagatat ctacaaaagt accaagaatt acaaaaacat tgaagaacct caaggagtga     1860

agattcttag attttccagt cctattttct atggcaatgt cgatggtttt aaaaaatgta     1920

tcaagtccac agttggattt gatgccatta gagtatataa taagaggctg aaagcgctga     1980

ggaaaataca gaaactaata aaaagtggac aattaagagc aacaaagaat ggcatcataa     2040

gtgatgctgt ttcaacaaat aatgcttttg agcctgatga ggatattgaa gatctggagg     2100

aacttgatat cccaaccaag gaaatagaga ttcaagtgga ttggaactct gagcttccag     2160

tcaaagtgaa cgttcccaaa gtgccaatcc atagccttgt gcttgactgt ggagctatat     2220

ctttcctgga cgttgttgga gtgagatcac tgcgggtgat tgtcaaagaa ttccaaagaa     2280

ttgatgtgaa tgtgtatttt gcatcacttc aagattatgt gatagaaaag ctggagcaat     2340

gcgggttctt tgacgacaac attagaaagg acacattctt tttgacggtc catgatgcta     2400

tactctatct acagaaccaa gtgaaatctc aagagggtca aggttccatt ttagaaacga     2460

tcactctcat tcaggattgt aaagataccc ttgaattaat agaaacagag ctgacggaag     2520

aagaacttga tgtccaggat gaggctatgc gtacacttgc atcctgaaag tgggttcggg     2580

aggtctctat gagcaaggaa tacaagacaa aacttcctca atgcattgac tatttcttca     2640

gactcaaaac actcattctt ttttctatta agccattgaa agagaagcac taagactgct     2700

tctaggcttt atttataaaa taaacacctt atccctaaca tgggcaaaat ggctagaatt     2760

attcagacga tttggcagcg tccagggtaa gctggtgtta taatacgctg ctgatctaca     2820

tcacagattt gctaataatg ttcacgtggg ccctggcata tctctgttca gttagagtga     2880

gtgctgaccc aacagcctct gtggtcaagc gagtcacgaa tgattaatca taaagaaaaa     2940

tcagtttttg actgacctgg atatccatga gctgcactga tcaccatgta aggtcacatt     3000

tagtaaatgc tgaaataaaa tgattaatgc atttatcaat aaaagccttt gaaaatactt     3060

tggataataa attggagttt taaaaatgca aatttgctta gtatctaata atgaagtgtt     3120

attacatata gccggaattg aggatctctt tgatcctgga aatggtttac ctaaaagcta     3180

cagaaccagg ccaatatatt ttgaaatatt gatgcagaca aatgaaataa taaagagatt     3240

ttcatggttt ataaaaatct tttttgatat gataataatc atgatcacaa ctgagatcaa     3300

aaaaatatat gacagattat tttgtttaaa aatgcagttt taattatctt agtctataga     3360

aatgatcatt gcatggaggc atgtataggt atgatctgtg taaaatctga cataaaaaca     3420

gtgctattct gagtgaaaat ttttttgatg tgcttacata accatggtga ttaaaatgag     3480

tttatatttt ttctcaaaaa ttttagcagt gtgtaaagta agtaatcttt aactgaactc     3540

tgaccactta aaaaaaaatc taaaaattga actacctata gtagtctgtg tttaaagtga     3600

atttttaaag acaaagcatt ctaaatgaac tcaatataaa aacattcatt tggaatgtac     3660

atactgaaaa atacaggttt ttttgaccaa aagtttttat atcttttctt tttatttatt     3720

tttttcctaa gtgccaacaa ttttctagat attatataca acacaggctt tgatcttggg     3780

gacttttccc atatatttca cactggagtg aatgaagttg tacttcattt ctagagaaaa     3840

gttataccca ggtccccaat tgagaatgtc ttgcttgatt gaaaacgaca tcatcccttg     3900

gtatactcca gggattggtt tcaggacccc tgcatttacc aaaatttgtg cacactcaag     3960

tcctgcagtc acccctgcct aaagatagaa tggcttctct gtttttcttc tgaaatacaa     4020

ccagaaacaa tgtgtctatt tctgaaagaa taggattaat gatcatacaa atgggttaat     4080

cctgaattct ggttgtaaat ctggttacag cataactagg attataatgc tgcctcattt     4140

tcacagcact acttgcttat attgacaaca aatcatctcg ctaaagagtg aatgtaggcc     4200

aggcgcggtg gctcatgcct gtaatcccag cactttggga ggccgaggcg ggtggatcac     4260

gaggtcagga gatcgagacc atcctggcta acatggtaaa accccgtctc tactaaaaat     4320

agaaaaaaag aaattagcct agcgtggtgg ctggcgggcg cctgtagtcc cagctatttg     4380

ggaggctaag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt gagccgaggt     4440

cgtgccactg cactccagcc tgggcgacag agcaagactc cgtctcaaaa aaaaaaaaaa     4500

aaaaaaaaaa agagtgaatg taatagtctt gcagaaaatg aatgaatacc tttgttcaat     4560

aaaggaaata tgcactgctc acttttttga aggaaatgcc aaagttacgt tttacaacaa     4620

ggctagagtt tgtaaattct gggttcattt gtgatgacat aagtcagcaa actgcgggaa     4680

tactgtctct tctatgtatt ttgtgaatag taagcataat tttagttttg tattatcaat     4740

gaaaatttca cttgaaatta aagctgcctt ttgttatatt tttaacctat aggataagat     4800

tccagtattg tatatgagtt ttaacaaatt aaaaaatcaa atcatgtaca tttgaaaata     4860

tttgcacaca tttaaaaata aatgtaaagt tgtcttttaa actactcgga tgtgtccttt     4920

ctgaacaaaa                                                            4930


<210>  56
<211>  3197
<212>  DNA
<213>  Homo sapiens

<400>  56
aaagttccaa ggagatttta aggtgcacgc aaggtggaaa accactgctg aagcagatgt       60

ggagaactat aaattaagga tcccagctac ttaattgact tatgcttcct agttcgttgc      120

ccagccacca ccgtctctcc aaaaacccga ggtctcgcta aaatcatcat ggattcactt      180

ggcgccgtca gcactcgact tgggtttgat cttttcaaag agctgaagaa aacaaatgat      240

ggcaacatct tcttttcccc tgtgggcatc ttgactgcaa ttggcatggt cctcctgggg      300

acccgaggag ccaccgcttc ccagttggag gaggtgtttc actctgaaaa agagacgaag      360

agctcaagaa taaaggctga agaaaaagag gtgattgaga acacagaagc agtacatcaa      420

caattccaaa agtttttgac tgaaataagc aaactcacta atgattatga actgaacata      480

accaacaggc tgtttggaga aaaaacatac ctcttccttc aaaaatactt agattatgtt      540

gaaaaatatt atcatgcatc tctggaacct gttgattttg taaatgcagc cgatgaaagt      600

cgaaagaaga ttaattcctg ggttgaaagc aaaacaaatg aaaaaatcaa ggacttgttc      660

ccagatggct ctattagtag ctctaccaag ctggtgctgg tgaacatggt ttattttaaa      720

gggcaatggg acagggagtt taagaaagaa aatactaagg aagagaaatt ttggatgaat      780

aagagcacaa gtaaatctgt acagatgatg acacagagcc attcctttag cttcactttc      840

ctggaggact tgcaggccaa aattctaggg attccatata aaaacaacga cctaagcatg      900

tttgtgcttc tgcccaacga catcgatggc ctggagaaga taatagataa aataagtcct      960

gagaaattgg tagagtggac tagtccaggg catatggaag aaagaaaggt gaatctgcac     1020

ttgccccggt ttgaggtgga ggacggttac gatctagagg cggtcctggc tgccatgggg     1080

atgggcgatg ccttcagtga gcacaaagcc gactactcgg gaatgtcgtc aggctccggg     1140

ttgtacgccc agaagttcct gcacagttcc tttgtggcag taactgagga aggcaccgag     1200

gctgcagctg ccaccggcat aggctttact gtcacatccg ccccaggtca tgaaaatgtt     1260

cactgcaatc atcccttcct gttcttcatc aggcacaatg aatccaacag catcctcttc     1320

ttcggcagat tttcttctcc ttaagatgat cgttgccatg gcattgctgc ttttagcaaa     1380

aaacaactac cagtgttact catatgatta tgaaaatcgt ccattctttt aaatgttgtc     1440

tcacttgcat ttccagtctt ggccatcaaa tcaatgattt aatgactcca ataatgtgtg     1500

tgtttataac catcctcgaa agtgaaatgt ccttttcttt gtgccatgcg taaggtgagt     1560

caaaccaaac ctcattgata atctcccttt ggtttccttt gaaagtaaat tggtatcttg     1620

tagttttgtg cacacgaaag gagagaaagt ctctccagta aagagtacga actagtaatt     1680

ttggggggtc tctctaattc tggtattttg acatgttata atacgcaagt aaaataaaac     1740

aatagtttac tcagctcatg ttactattcc ccaacagata ttgtggcaaa tcacacatag     1800

gaaagagaat ttgggaatac agtagcaaaa cataaattaa aactcaaatg ccaggacaaa     1860

ataaaacaat ataccagatg gagaggatgc ccgtattttc atcttccatt ctaacattat     1920

ccattgttag atgcataagc attttgatat tgtgtaataa atgtggtatt tgagaagata     1980

aatgatgtag ttgatcagta ttcctcctct atcacctttt tagactttgt aaggtaaata     2040

tttggactaa cttttagaaa agtttccctt tttttctcca tttacatttt tctggttttt     2100

tttttttttt gagtgaggta cgagtattac caaatgatat tttctgaaga tgctttttgg     2160

aaagctctga atctatacct aatgctctta attattggct tgtttcattt ttttcctcca     2220

gtttttaaca agatcacata actggcttat ttttaacagc tttgtcaaac tacaatttac     2280

atgccgtaaa atgtacacac tgtaatttta taattcattg acttttagta aatttctagc     2340

gttatgcatc gccacaatcc agttttagaa tatttccatg accctaagaa gtttcctcat     2400

gtctattaat attcccaatc ctaggcacca ctgagttgtt ttctgtcttt ataagttttt     2460

ctttctacat cttatataaa tggaatcata atacatgtag tattttgtgt ctggcgtctt     2520

gcacttagca tggtgttctt gaggttcatc tgttgtagta tgtattgata cttaattttt     2580

ttattgccga atactattcc attgcatgga aaagacctat tttatttcta ggttcaccag     2640

ttgagggaca tttggattgt tcccacttct tggctgttag gaataatgtt gctctgaaca     2700

tgtaaataaa gatctttgtg ttcacatatg ttttcatttc tgttggggag attcctaggc     2760

tagaaattgc tgggccatat gaaaaatcaa tagttagctt tgtaagaaac agtcaaactg     2820

ttttccaacg tgacatttta tattcccacc aggaatgttt aaaactagtg tcttcaaatc     2880

ctcaccaaca tccaggattg tgtctttatg attatagcca tttttgtagg tacaaagtgg     2940

catctcatgg tggttttaat ttgcatttcc ataatatcta attaggttga gcttttttta     3000

tgtgcttatt ggccatttgt ttgactttgt ttggtgaaat gtatacaaat catttgctca     3060

tttttaattt gggttgtctg tcttgtcttc tcattttatt gagttaaatg agttcttaat     3120

aatctctggc ttacaagtcc ttaatttatc aaatatatga tacgtggaca tttcctcata     3180

aaaaaaaaaa aaaaaaa                                                    3197


<210>  57
<211>  2940
<212>  DNA
<213>  Homo sapiens

<400>  57
aaacatctgc aaaagcgcaa ggagaccagc ccacatttta gcccctccta ctcaggataa       60

gactttctct aagtccggag ctgaaaaagg atcctgactg aaagctagag gcattgagga      120

gcctgaagat tctcaggttt taaagacgct agagtgccaa agaagacttt gaagtgtgaa      180

aacatttcct gtaattgaaa ccaaaatgtc atttatagat ccttaccagc acattatagt      240

ggagcaccag tattcccaca agtttacggt agtggtgtta cgtgccacca aagtgacaaa      300

gggggccttt ggtgacatgc ttgatactcc agatccctat gtggaacttt ttatctctac      360

aacccctgac agcaggaaga gaacaagaca tttcaataat gacataaacc ctgtgtggaa      420

tgagaccttt gaatttattt tggatcctaa tcaggaaaat gttttggaga ttacgttaat      480

ggatgccaat tatgtcatgg atgaaactct agggacagca acatttactg tatcttctat      540

gaaggtggga gaaaagaaag aagttccttt tattttcaac caagtcactg aaatggttct      600

agaaatgtct cttgaagttt gctcatgccc agacctacga tttagtatgg ctctgtgtga      660

tcaggagaag actttcagac aacagagaaa agaacacata agggagagca tgaagaaact      720

cttgggtcca aagaatagtg aaggattgca ttctgcacgt gatgtgcctg tggtagccat      780

attgggttca ggtgggggtt tccgagccat ggtgggattc tctggtgtga tgaaggcatt      840

atacgaatca ggaattctgg attgtgctac ctacgttgct ggtctttctg gctccacctg      900

gtatatgtca accttgtatt ctcaccctga ttttccagag aaagggccag aggagattaa      960

tgaagaacta atgaaaaatg ttagccacaa tcccctttta cttctcacac cacagaaagt     1020

taaaagatat gttgagtctt tatggaagaa gaaaagctct ggacaacctg tcacctttac     1080

tgatatcttt gggatgttaa taggagaaac actaattcat aatagaatga atactactct     1140

gagcagtttg aaggaaaaag ttaatactgc acaatgccct ttacctcttt tcacctgtct     1200

tcatgtcaaa cctgacgttt cagagctgat gtttgcagat tgggttgaat ttagtccata     1260

cgaaattggc atggctaaat atggtacttt tatggctccc gacttatttg gaagcaaatt     1320

ttttatggga acagtcgtta agaagtatga agaaaacccc ttgcatttct taatgggtgt     1380

ctggggcagt gccttttcca tattgttcaa cagagttttg ggcgtttctg gttcacaaag     1440

cagaggctcc acaatggagg aagaattaga aaatattacc acaaagcata ttgtgagtaa     1500

tgatagctcg gacagtgatg atgaatcaca cgaacccaaa ggcactgaaa atgaagatgc     1560

tggaagtgac tatcaaagtg ataatcaagc aagttggatt catcgtatga taatggcctt     1620

ggtgagtgat tcagctttat tcaataccag agaaggacgt gctgggaagg tacacaactt     1680

catgctgggc ttgaatctca atacatctta tccactgtct cctttgagtg actttgccac     1740

acaggactcc tttgatgatg atgaactgga tgcagctgta gcagatcctg atgaatttga     1800

gcgaatatat gagcctctgg atgtcaaaag taaaaagatt catgtagtgg acagtgggct     1860

cacatttaac ctgccgtatc ccttgatact gagacctcag agaggggttg atctcataat     1920

ctcctttgac ttttctgcaa ggccaagtga ctctagtcct ccgttcaagg aacttctact     1980

tgcagaaaag tgggctaaaa tgaacaagct cccctttcca aagattgatc cttatgtgtt     2040

tgatcgggaa gggctgaagg agtgctatgt ctttaaaccc aagaatcctg atatggagaa     2100

agattgccca accatcatcc actttgttct ggccaacatc aacttcagaa agtacaaggc     2160

tccaggtgtt ccaagggaaa ctgaggaaga gaaagaaatc gctgactttg atatttttga     2220

tgacccagaa tcaccatttt caaccttcaa ttttcaatat ccaaatcaag cattcaaaag     2280

actacatgat cttatgcact tcaatactct gaacaacatt gatgtgataa aagaagccat     2340

ggttgaaagc attgaatata gaagacagaa tccatctcgt tgctctgttt cccttagtaa     2400

tgttgaggca agaagatttt tcaacaagga gtttctaagt aaacccaaag catagttcat     2460

gtactggaaa tggcagcagt ttctgatgct gaggcagttt gcaatcccat gacaactgga     2520

tttaaaagta cagtacagat agtcgtactg atcatgagag actggctgat actcaaagtt     2580

gcagttactt agctgcatga gaataatact attataagtt aggttgacaa atgatgttga     2640

ttatgtaagg atatacttag ctacattttc agtcagtatg aacttcctga tacaaatgta     2700

gggatatata ctgtattttt aaacatttct caccaacttt cttatgtgtg ttctttttaa     2760

aaattttttt tcttttaaaa tatttaacag ttcaatctca ataagacctc gcattatgta     2820

tgaatgttat tcactgacta gatttattca taccatgaga caacactatt tttatttata     2880

tatgcatata tatacataca tgaaataaat acatcaatat aaaaataaaa aaaaaaaaaa     2940


<210>  58
<211>  2708
<212>  DNA
<213>  Homo sapiens

<400>  58
ctgataagat tgatttattt ggttaagaaa tacttttctt aaacctattt ttaaaaaata       60

acactcagta ttaccataac atgcacattt gaaatgtgag aactataaga gatgaaaatc      120

tgacaggtgc agttagtgaa acacaaagca ggaggagttg aaccaaaacc atcagttaaa      180

cattttgcat ttagacttaa ttctttgtta gaaaggttgg gaataacatg aaagccattt      240

taaccttgac aatgaaagga gattatcact taattatatt tcagtgacaa actgctttct      300

gtcaaatcca gcccacagga cacaaacaca atcttggcca caccttggca ttactggttg      360

gcggcattat ttccctatcc ttttgtgaaa cccattcaac atggaatcaa acaatagcaa      420

ctctggcaag aatcctccta tatacacaat gaagaaatat ttctgagttt cataagttat      480

aacacaagtg tcacacttct tttcacagca accgaagggc aggagttagt ttggctaaag      540

ctctcaggac attataatgg ctttagtatt tagaactgta gctcaactag ctggagtttc      600

attatctttg ctgggatggg ttttatcctg tcttacaaac tacctgccac actggaagaa      660

cctcaacctg gacttaaatg aaatggaaaa ctggaccatg ggactctggc aaacctgtgt      720

catccaagag gaagtgggga tgcaatgcaa ggactttgac tccttcctgg ctttgcctgc      780

tgaactcagg gtctccagga tcttaatgtt tctgtcaaat gggctgggat ttctgggcct      840

gctggtctct gggtttggcc tggactgttt gagaattgga gagagtcaga gagatctcaa      900

gaggcgactg ctgatcctgg gaggaattct gtcctgggcc tcgggagtca cagccctggt      960

tcccgtctct tgggttgccc acaagacggt tcaggagttc tgggatgaga acgtcccaga     1020

ctttgtcccc aggtgggagt ttggggaggc cctgtttctg ggctggtttg ctggactttc     1080

tcttctgcta ggagggtgtc tgctccactg tgcagcctgc tccagccacg ctcccctagc     1140

ttcgggccac tacgcagtgg cacaaacaca agatcatcat caagaactgg agacgagaaa     1200

caccaacctg aaacactaag ccagaaagga caagcgtctg ctgttcagga gacgcttgct     1260

caacactgga tttggtagga tgtcccgctc tagtcatctc actgtgcttt tgatttttga     1320

aaatgcatct tttcctgtgg ctattaaact atagtttctt tccaagactg gtaaaccatt     1380

tttatcttct agtctgagac caaaatcaat caagactgaa tagtaatgac acccattact     1440

gtggatgagt tttctcaatt ttaaaatagc gattgcacag aagtggtaaa taaaacatta     1500

atctctatgt atctttgaag gtattattca tatggagcgg aatcatttgg caaatcattt     1560

acttatttca ggtgtttaag ataacctagt ataataagcc tgaggtcttg ttgcatattt     1620

atttaaaatg catgacgtct tattatataa aataattact agctctttag aagcttcaga     1680

ggtgaaaggt gtagacacat catctccttc tgaatcagag acctcagtgt ctctatggaa     1740

cctttttcaa aaggcagcca cattcagtca cgccttctat actgtcagag gcaggagggc     1800

gatcttgggt tttggatgat tcaagtagac tctgccacac aaacgtgctt ctgcatcctg     1860

tgttctgtat ttcacgggca gcgtttctgg cttcccaggc actgagcagc ctgtgggggg     1920

cacggcaggg caggactggg gtgtgtgggt agataacctc ctgggacggc tgcctctctg     1980

tggagcacac tgccagccca ggcgcagcga ccacagagca catattctgg agcccttcat     2040

tttatttgct caatgaaaat acttcgtcct tttttatcag caatacatat agttccaaca     2100

agaactattc atcacaaact gccagcctgg ggatttcttc atgaaatatt ttgtatttgc     2160

ttggtacatg gttcaaggaa actcttgtgt ttgtgccaat cagggaaata aactgaacaa     2220

taaacgacac tgaaatagag tattaggcaa tatgtagctt tgtttttgct ttttttttta     2280

aaaaaaacca ctgaattttt ttccacccac aaacacatgg aaagtgcaga aaccagttaa     2340

tctatgtgat gtatttgcat acgtttacaa acaagacaaa ttaaaacaga aacatgttca     2400

gaatttaacc tgattaaata ttaagttcag tcctgagctt ttgatattta agacaatata     2460

gataaagcaa tagcaaaaaa ttttaattta tttgatttgc atgctacaga gatttagcta     2520

aactttgttc atttggctag caatattctt tttgtacctg taacacttaa gattctgata     2580

tacaaaattg taataatata ctgataattc aaacttgaga actaaatatt acattctttt     2640

taccctgtgc gaataaattc taccttttaa aaatagtatt tataatatta aaattcatat     2700

ttgtccat                                                              2708


<210>  59
<211>  2399
<212>  DNA
<213>  Homo sapiens

<400>  59
atagcagctt agaatcccag ctgctggctc gggctgcagt tctctcatgg ctcgcgcagg       60

gtggaccagc cccgttcctt tatgtgtgtg tctactgctg acctgtggct ttgccgaggc      120

agggaagctg ctggtagtgc ccatggatgg gagtcactgg ttcaccatgc agtcggtggt      180

ggagaaactt atcctcaggg ggcatgaggt ggttgtagtc atgccagagg tgagttggca      240

actggaaaga tcactgaatt gcacagtgaa gacttactca acctcgtaca ctctggaaga      300

tcagaaccgg gaattcatgg ttttcgccca tgctcaatgg aaagcacagg cacaaagtat      360

attttctcta ttaatgagtt catccagtgg ttttcttgac ttattttttt cgcattgcag      420

gagtttgttt aatgaccgaa aattagtaga atacttaaag gagagttctt ttgatgcagt      480

gtttctggat ccttttgata cctgtggctt aattgttgct aaatatttct ccctcccctc      540

tgtggtcttc accaggggaa tattttgcca ccatcttgaa gaaggtgcac agtgccctgc      600

tcctctttcc tatgtcccca atgatctctt agggttctca gatgccatga ctttcaagga      660

gagagtatgg aaccacatcg tgcacttgga ggaccattta ttttgccagt atctttttag      720

aaatgcccta gaaatagcct ctgaaattct ccaaacccct gtcacggcat atgatctcta      780

cagtcacaca tcaatttggt tgttgcgaac ggactttgtt ttggactatc ccaaacccgt      840

gatgcccaac atgatcttca ttggtggtat caactgtcat cagggaaagc cattgcctat      900

ggaatttgaa gcctacatta atgcttctgg agaacatgga attgtggttt tctctttggg      960

atcaatggtc tcagaaattc cagagaagaa agctatggca attgctgatg ctttgggcaa     1020

aatccctcag acagtcctgt ggcggtacac tggaacccga ccatcgaatc ttgcgaacaa     1080

cacgatactt gttaagtggc taccccaaaa cgatctgctt ggtcacccga tgacccgtgc     1140

ctttatcacc catgctggtt cccatggtgt ttatgaaagc atatgcaatg gcgttcccat     1200

ggtgatgatg cccttgtttg gtgatcagat ggacaatgca aagcgcatgg agactaaggg     1260

agctggagtg accctgaatg ttctggaaat gacttctgaa gatttagaaa atgctctaaa     1320

agcagtcatc aatgacaaaa gttacaagga gaacatcatg cgcctctcca gccttcacaa     1380

ggaccgcccg gtggagccgc tggacctggc cgtgttctgg gtggagtttg tgatgaggca     1440

caagggcgcg ccacacctgc gccccgcagc ccacgacctc acctggtacc agtaccattc     1500

cttggacgtg attggtttcc tcttggccgt cgtgctgaca gtggccttca tcacctttaa     1560

atgttgtgct tatggctacc ggaaatgctt ggggaaaaaa gggcgagtta agaaagccca     1620

caaatccaag acccattgag aagtgggtgg gaaataaggt aaaattttga accattccct     1680

agtcatttcc aaacttgaaa acagaatcag tgttaaattc attttattct tattaaggaa     1740

atactttgca taaattaatc agccccagag tgctttaaaa aattctctta aataaaaata     1800

atagactcgc tagtcagtaa agatatttga atatgtatcg tgccccctct ggtgtctttg     1860

atcaggatga catgtgccat ttttcagagg acgtgcagac aggctggcat tctagattac     1920

ttttcttact ctgaaacatg gcctgtttgg gagtgcggga ttcaaaggtg gtcccacggc     1980

tgcccctact gcaaatggca gttttaatct tatcttttgg cttctgcaga tggttgcaat     2040

tgatccttaa ccaataatgg tcagtcctca tctctgtcgt gcttcatagg tgccaccttg     2100

tgtgtttaaa gaagggaagc tttgtacctt tagagtgtag gtgaaatgaa tgaatggctt     2160

ggagtgcact gagaacagca tatgatttct tgctttgggg aaaaagaatg atgctatgaa     2220

attggtgggt ggtgtatttg agaagataat cattgcttat gtcaaatgga gctgaatttg     2280

ataaaaaccc aaaatacagc tatgaagtgc tgggcaagtt tacttttttt ctgatgtttc     2340

ctacaactaa aaataaatta ataaatttat ataaattcta tttaaaaaaa aaaaaaaaa      2399


<210>  60
<211>  3919
<212>  DNA
<213>  Homo sapiens

<400>  60
aaagtctttg cagcctcgct acggggcgga gtcttgcctg tcagcagggg cagagtagcg       60

atcgtcgcca aagcgcgcgg ttttatttct ctccgctttg gacggggcaa actagctttt      120

gggagtgaag cgggtacgca gttatccaac aatgtctggt gagtcaggac agcctgaggc      180

tggtccctca catgcagggc tagattggcc gaaccctgag aggaatcggg ctggggtccc      240

gggaggggtg atccgaagag ctggttccca agggcccagg tcctggatcc aaaaggttct      300

tgagcagatt atggactcac ctcgccagtg tgtcaccccc tcggaggtgg tgcctgtaac      360

tgtgctggcc gtccagaggt acctgttaga ggatgagcca cgcgacacgg tgcccaagcc      420

tcccctttat tgctatgatg tgacgatctc agatggggtg taccaggaga agtgctacct      480

ggaccccagc ttgaactctc tcgtatatca aaatattctt aaagttggca ttcaaatgag      540

aatttccagg gtctcatgtc tttacaatga gaaaaggata ggccagggga tcctgtgcat      600

agataacgtc cactgtgggg agacttcaga cagtatttct ttagaaactc ccttcagaaa      660

tagagcgcac caggagaaac cagagaggcc tttaagaggc gggaagagtc attacctggc      720

gctgtggaat aacgaagatc cctatggaga tatctggtta acagacaagc aacctgagga      780

acacaacttt agcgatacca aaataatttc cctttctcat cttgaaatga cctggactaa      840

cagaagaaat tttcctgcat tgcttgtgag gatcttacat aaatcaaaac tgcgatacta      900

tggaaaacct gataaaaaga tgattgaacc atatcagacc tttttggaag ttgctgacag      960

ttcaggcaca gtgtcagtga ttatgtggaa tgccctgtgt cctgagtggt ataaaagttt     1020

gcgggttggt ttagttcttc tgcttcaaga ctattctgtt aaaaagagtt atccattcag     1080

aatacagcct gtccccgtgg atccacagat caaactaatt tctacaatgg aaatctgcct     1140

gaatcttcga gatcccccaa caaatataat tatcattcca gaaaagcagg tgaaaccaga     1200

atggagactg ccaaagctaa atcaccgatt taccacaagg tcagaactgg atgatatgcc     1260

agaaaattgc atctgtgatg ttattggcct tttagttttt gtaggaaggg tccagcggtc     1320

aaaaaagaaa gaaaaccgtg aagatttttg gtcatatcgc tggattcaca ttgctgacgg     1380

tacttcagaa caaccattta tagtggaact gttttcaaca tcgcagccag aaatctttga     1440

aaatatttac ccaatggcat attttgtgtg tacacagttg aaagttgtca gaaatgacaa     1500

tcaagtacct aagctgcttt acctcaccac tacaaatgag agtggagtgt ttattactgg     1560

tcatagaggc cagccgtata cgtatgatgc caaggtaaaa aactttattc aatggattag     1620

aacaaagtct gattccgggg aacagaagaa tatggttatt ggtggatatt acccctatcc     1680

accagtgcca gagacatttt ccaagtatag tagttctatt aaagttgagt cgctcttgac     1740

agctataagt gaagtcagga aggagattga agacttgcag tatagggaac aaaagcgcat     1800

tgcaattcag gggataatta ctgctataaa gtatatcccc catagcagtg cgactgaaag     1860

tgcctcagca tcagaaacac ttcggaatgc taacagaccc tcgacctctc aagcagctag     1920

agtagaaatt caagaaagaa atggtaaacg gcatcaagat gatgagcctg tgaattctca     1980

gtatttccaa actacatcta caaatttaag tctgagcaat aaaataagaa ttcttcaagg     2040

cccacacgct aatccagttg ctgtacctca accaggagct tctgtacaaa caaagggaat     2100

taaaccgggc atgccaagca tcttcaaccg tcgagcaaat ataaatgcta atctgcaagg     2160

gaaagccaga aaaactataa gtgataggtg ggagagtcag ctgtggagag agaaaaagtt     2220

tggcttaata gatcacctac actacagccg tgtttatcct gaaagtattc cacggaaatt     2280

tatgtttgaa cacagaaagt ttcttagtga ccagtataat tctcagcctg cgaaatatgt     2340

accaccagaa ggaaggcccc caaaacttga tgattttaag agcgcccgaa gccttggaca     2400

ttttgaagta accatactag gtctgaacca tgagatagca atcgatgttg ctttcctacc     2460

catgtattgt ccagaagata ttcgaacatc tcaaatagac acactgttga cctccatgaa     2520

ttacagctgt gcatatccac aggacacaac tggaaatgac cgattgccag gtccaagagc     2580

ggttgcaggt gatattataa aagcagcaac tgaactggat agagtgcata tcgtcggtat     2640

cttggatatc tgtaatttgg gtaataataa agtggaagtc tatttgcaca agatttatag     2700

tccagagaat acttcttaaa agttagcaaa tgaaattatt acagattata cgagtgtact     2760

gctttaaaga tattccatca ttttgctggt aatttcagta actgttttca gcaagaatat     2820

tacatgagct ctaaagttat taagcagttt tatgttcgtt ttgtgtttag ggagcttttt     2880

aaaacacttc atttcagatt cattattgaa aaaggtcatc aaaataattt ttgtgtataa     2940

gggaatttac cttgcttacc ttactagtat gactattatc ttgacttctg gtaatttatg     3000

ttcactattc catttgtgaa gtgtactttc attctaaagc ctcagtataa ggcatcctaa     3060

cttacaagag taactttcca tggacattta acatccttcc aattttattc acatataatg     3120

ggaaattttg aattgccagt ttgaagactg ttctcctaaa gtgttcaacc tgcacttctt     3180

acaaccaagg tagtttgtat cattttcaaa agtacacatt attagggtct agttgcccct     3240

ggtccttagc ttgctcagct gcaaaataag cgtgctaaat taaattgtct taaggttttt     3300

ccacttcatt ttgtgacttt gtgtggttcg aatttctcag tattttaacc agtgtgttga     3360

tgttaaagtc aaaggctgca gtatgtctat attcttgctg tactcattgg tagtttcagt     3420

atatgtaatg tgagtttaaa tagtgaaatt gtatctcata ttaacatttc aaatgctcat     3480

attgaaaatg gaaaatagta aacacgggaa ttgattttat tctggttgtc tataatactt     3540

cattttaaat gtaaatggcc actctgcatt tgcaaggccc ggtggttgac atctgtgtgg     3600

tttgttagat gagacaaaat gaccattaaa tgagtttata gattattctg tatcaagata     3660

aatctgattc cagttaagct ataaacttgt gggattttct tgtagcccta tagttctgtg     3720

acttcatttg ctatacgctt taaatgtgtt gagcagccta tgaacctaaa gacatactgc     3780

agtttgttca taaatgtatt cagtctttta ttctttataa ttgtgtgtaa atgttaacta     3840

aacagtggat tcctctcgtg ttacagtttt gagtgaatta ttaaagaagt taaaatgcaa     3900

taacaaaaaa aaaaaaaaa                                                  3919


<210>  61
<211>  7844
<212>  DNA
<213>  Homo sapiens

<400>  61
taattgcttg aaggattttt tccagacagg tggtctggaa accttttacc tattaccttc       60

catccctgaa ccatttcaat cttctgcctc ctggatatct tggagaaaat gaaccaacac      120

aacacagctt tcagttttta gagcatttcc cccatacaga acattgtctt acttgatctt      180

cccgatgacc tcaacaacag gaaaggcagg tcctttcatt tccatttata agacgcacag      240

acccaggatt atctagccac aggaagcagg actccagatt tcaagtccag catctcaacg      300

tgacaacctt ggtaactctg catgaacgga ctggatagta aagtggaatt attactgaga      360

actgcaatga ataaaatctt ttgcattttt tgcctacgtt tcacagaggg tgatattttt      420

ctgaggcaat taaatttata ccacggccac aatactgaaa cgttctgacc aacaaagtca      480

tgctcctgca tctacacagc agataactgc agaaacggct tcctttcttc cttgtaaaat      540

tgcctgaaaa cagctccccc ttgctgtccg tcgaggcata tcttcaccaa cgttaaaaca      600

gagctgaggg agatcgcatt tctgcctccc tcccgccctg cagaggggct ccagctgttc      660

agagtaacgg attactaggt aggtggttgt ttcccctcct tcccagggcc tctttcctct      720

ctttgagatt gcctctttct tactcctgag cacaggagcc gggcgggttt tctgtccctt      780

gccctggaca gcactgcctg gatggccgct gtccggcagc tgctctttgt ccacccaaaa      840

agatgtcccc acgactcagt agtaaccaga cggtccccac ggaccactgc ggccaaattt      900

ccgccatccc cgctgtggga atcaggcttt tcccgcagaa aaccccagga atctagagaa      960

aactccttaa gtccctagtc tccatagaga aaaccaggag acactccccc caaaccccgc     1020

tgtgaataca ggcacagcag ccactggggc tgcaaagtga tgagtgcgtt cttcccgtcg     1080

caaacatagg gtaataaata gcatgcatca aagacgttac taggaagaga tagctcttta     1140

agtcacgagc ggggagaaat gtttgccccg ggaaaatttg cctggggaat aaaatttgcc     1200

agactgctgc acgggtgagc tcggtgagaa ggaagaaacc cggactggag gaggtgaggt     1260

cgagagccag gttcaggtgc aggagctaga tgcgtggacg ccggtgcgtg gactggaggt     1320

ttccaggtac cgcgcttagc gtgcctgttg aagtcaaatg catggttaag gaggctagcg     1380

aggaaggcta gtgagggaag cttgtggaaa cggctacgag cccagaaaag gcatgactcg     1440

tccagttgtc caagtttttg gaagggaaaa gcgggaaagc gccacgatcc cacctactgt     1500

gaggaggaat ctgcgagtct cccagctcca ccccctccac agtgatgcag aggacaaaca     1560

ccgacgtagg gagaggaaaa aataaaactc cagggagcgg ggagtaggca accagcagtc     1620

ttccggcaat agggcgggag ggagcgcgtc ccaaggaaac aagcaccgca taaatacttg     1680

agttgggaac ccagtgcttc cggaagctcg gagctcacct tcccgacctc gccgaagttg     1740

aaaaaaggca gagcagggag aggggccagc tcaccctgct gagagctgct cagtgggcag     1800

gcgggacgct gctccgggag acgcccactg gagggatcgc agagcccggc aagctgcgag     1860

cgcgccaaag accctgcgct tcggacgagg agcccaagtc ctccgagacg gggagggagc     1920

ggcccgcgag ggctggagct ccgaagaggg ccgagtagga gctgcatgga cagcatgcgt     1980

ctctccgccg gtcccgacgc ggggccctcg ggcaactcca gcccatggtg gcctctggcc     2040

accggcgctg gcaacacaag ccgggaggcc gaagccctcg gggagggcaa cggcccaccg     2100

agggacgtgc gcaacgagga gctggccaaa ctggagatcg ccgtgctggc ggtgactttc     2160

gcggtggccg tgctgggcaa cagcagcgta ctgctggctc tgcaccggac gccgcgcaag     2220

acgtcccgca tgcacctctt catccgacac ctcagcctgg ccgacctggc cgtggcattc     2280

ttccaggtgc tgccgcaaat gtgctgggac atcacctacc gcttccgcgg ccccgactgg     2340

ctgtgccgcg tggtgaagca cctgcaggtg ttcggcatgt ttgcgtcggc ctacatgctg     2400

gtagtcatga cagccgaccg ctacatcgcg gtgtgccacc cgctcaagac tctgcaacag     2460

cccgcgcgcc gctcgcgcct catgatcgcg gccgcctggg tgctgagctt cgtgctgagc     2520

acgccgcagt acttcgtctt ctccatgatc gaggtgaaca atgtcaccaa ggcccgcgac     2580

tgctgggcca ccttcatcca gccctggggt tctcgtgcct acgtgacctg gatgacgggc     2640

ggcatctttg tggcgcccgt ggtcatcttg ggtacctgct acggcttcat ctgctacaac     2700

atctggtgca acgtccgcgg gaagacggcg tcgcgccaga gcaagggtgc agagcaagcg     2760

ggtgtggcct tccaaaaggg gttcctgctc gcaccctgtg tcagcagcgt gaagtccatt     2820

tcccgggcca agatccgcac ggtgaagatg acttttgtga tcgtgacggc ttacatcgtc     2880

tgctgggcgc ctttcttcat catccagatg tggtctgtct gggatcccat gtccgtctgg     2940

accgaatcgg aaaaccctac catcaccatc actgcattac tgggttcctt gaatagctgc     3000

tgtaatccct ggatatacat gttttttagt ggccatctcc ttcaagactg tgttcaaagc     3060

ttcccatgct gccaaaacat gaaggaaaaa ttcaacaaag aagatactga cagtatgagc     3120

agaagacaga ctttttattc taacaatcga agcccaacaa acagtacggg tatgtggaag     3180

gactcgccta aatcttccaa gtccatcaaa ttcattcctg tttcaacttg agccttgcat     3240

tcatgcaact tgattcttgt gattgacttt ttggctcatt agctgaattg agctagaaat     3300

cacaagaaca aatacacttt attaatataa ccataaatca attcattgtg tatgagactg     3360

tgtttctagt tgcattttca tattgctacc aaaaactaga cattattttg tatggaatat     3420

taatggaaac atgctgtact aaaatatgca ggtctgattc ccagaaatac aacagaagtt     3480

atatttttaa aggaaaaatc ataaccaccc tagctttata ttttgttgtt agtttctttt     3540

attttcattt ctaacataag taagacttga ttggtttaaa agtcacataa aatgcggcac     3600

tatttctgaa caaagagagc tcatcatcag tcttaatatt cagagaaaac ttcagagaaa     3660

ttatgttttc atccattaaa attaatttgt gcatcagaaa atgcagcctt aaacagtgtc     3720

caggagatgg gatggtacct cctaggagta caagtgcctg gggtgtaatg agctcctgct     3780

cattgtggcc agtttagagt tctattagaa gctatcaatc accttgcatt tcaaaatggt     3840

aactttacaa ctggcagtgg cctccttttg gttcctcaca tattattggt caagaaaagc     3900

atgaaaactg agatgctgaa ggtgagagga aatgttgact ggccaaaaat atcttttttc     3960

ccccactgcg aggttgtttt aaagtcagat ttgtataagg aaagccaaat tttattaaaa     4020

gagtagaaaa ggattgctta aggtactctg gactttctct tggacattgt aaacgtattt     4080

tgatcagtgt tacaagggta tcctgtgcta tgctggacat taacaagatc attatcttca     4140

tgtttgggga attcagattc ataatatgag tatcctaaag agtgactcag gatataaagt     4200

gtcccaacat gtttaattaa aaatagcttt gtctttccaa tctctcactc atctaacaat     4260

tgcaaagcag agatgagaca gggttgggac atgggtgaca gatggaaaga gaactgctct     4320

gtgcccagac tggcttcctt cattattaaa tccacaactt taggcaagtt tcttaaacac     4380

atataaagcc tctgtttcct tgacttaccg tggggttgat aacacttacc tcacagggtt     4440

gttgtaagga ctaaatgaaa tcaaatatgt taaaagagct tcagaaatag taaagtacta     4500

tacacatgct agcagttgct tttattatag ccttgggatc tccaaaattg cacagatgtt     4560

ttccagttta tttttcatta actagaattg gttcatttca tggctgggat ataaaatcct     4620

aaaatttaaa tatagatcgc tgattcattg gacaacattt ccagtgactg ctcagcttga     4680

cttctcctgc ctgactaaag ttttccaatt taaagacaga acttgctttt ctttgaatgc     4740

aggtagatca aagccaccca caagcatcaa ttttttccat ttttaaacgg agaccaatta     4800

cactactttg ctgttattac atttttcatt aatggaactc agtgattttt ttcctagcta     4860

ttttgtctgg ctgcttcttc ttcttagaga tcatgcaatg atttgaggat acatcataaa     4920

tattttgcat ccttaagagg aagtaatagt tgcttttttt ttttttgaaa cagagtcttg     4980

ctcttttgcc aggctggagt gcagtggcgt gatctcggct cactgcaacc tccgcttcct     5040

gggttcaagc gattctcctg cctcagcctc ccgagtagct gggactatat gcatgtgcca     5100

ccacacccag ctaattttta tatttttagt agagatgggg tttcaccatg ttggccagca     5160

tggttttaat agtattattg agtttctttt tttacctttg tagataagaa aatgagaact     5220

ggatagcact gtgagaaccc ggaagcgata acttcactcc tcttcattct tctgcctttt     5280

gaaattctca gcccttaggc tccttgtatt gataggccta aaaacatgtt tccaaatgct     5340

ttatagagat tataaaccta gggactccct aggttttcaa attcttcttt ctaaaaataa     5400

caaatatgtc tcttaaaggg tactgtccaa tataagccat aactaaatta attaattcat     5460

tatttgagtt agagtagcat ctcagtaacc cagcactcga agactgtcag tccttttaac     5520

aactctttga tagttcaaaa actaaagctt tttggtttgg aactaagatg aacccatttt     5580

tttctaaatc catttccaaa gtaagaacct cagaacctat agatcttgct tcaaaatgtt     5640

gatatgtacc cccaagcaaa acaattcaat ttgaatgtta tttctgagaa cagctcacaa     5700

aaaaaagtgc atatcaccct acccagttgt attttctcct tttaaatgta ttgggagatg     5760

agacagtaga aaatgggctg gggaaacatg agatctgggt gctagttctg cactaggcaa     5820

atacatggtc ttattctctg cggtttaggc tgagaagttt catctgtctg gttgctaaat     5880

tttctcaatg ttatgtaccc agaaatggac gccacatatc tcaaaacaat atttcagatt     5940

ggaaggaatc tacctgcctg tctgtttcag aagaagagaa actgaaaaag tattccggga     6000

agggaagttt tccttttctt gactaaagag aagacctgag atattatgcc aaataacagc     6060

ttacagtcaa gaaaaaaatg tgttgcagca ccttatttta tttttcacag ttaacagtgg     6120

gaagatcctg caagtacaca attttaatgc ctctatatgg gtattaggaa tgtgatatat     6180

aaaaaatgtc cagtagggag aaactaatca gttgggcatt tgatgaatat taactgatga     6240

tggtaaataa acaatttaga gtgcattatt aagtgcttaa tgggttaatt ttggagcatg     6300

tattctaaag tgtaaaacta cttggctttt attttgaaat ttcatttgga acacaattgt     6360

gaaggaaatc agtgaaattc ttgggttaat tatatacttg ttttacatat agaatttcta     6420

tcatcatcaa acaagtctta tgccatgatt tcgggaaggg tatggtttta gagaaaaaaa     6480

tactaagcag tcttaatgat acacaggacc ctgccaagct tattacagtt tctagaatgg     6540

acaactacta atgattaaga aacaactttc atctgttatt acacaagaaa cccgattagg     6600

ttaaagtttg atgttttcag actctaaagc ctatgttttt gtaacttaat tggactttca     6660

gagtgttaaa ttatggcttc agagtttggc tctacctaaa atttagttag atgccaacca     6720

gggagaaatt aaacctaatc cttcacccca aatatcagag gttagacaaa cccatgttaa     6780

ttggagcctt atggttattc atattggagg caatagcttt atttagagga agcccaggac     6840

agggccgtct gggatgctag ttctggaaat gcagaagcag ccactgtatc cctgcccacc     6900

ccctccatcc agcccttttg gtactactca gtattgttga caacatttgg aatcataagt     6960

aacataggac agtaagtatt agagaatgat tctccgttag aattggacct cagccgattt     7020

gagccaaaat ttaggaacta ttcagaagac agtttctttc ttttgagtgc ttaagacagt     7080

gtaaatggtt cgaatcacac acattttaag attccattgt atacataagc attttaagaa     7140

tattgtttta acataattat taggcatact aagttatcat gaatgaaaat gtacatgtga     7200

cctgtagtat gttatatatt attatggcta aatgttaaat gccatttttt tgctttttag     7260

ttttatgtat ttttgtatgt atatacccac atttttacat tgatttatgt tctaaataat     7320

aattaaaaca aagtattata aaatgaatga aatatttttg tgttccatgg tcaaattatt     7380

aataaattca ggaaagaaaa tctgatgata aatctgatat aaataccaga ataattatta     7440

ttaatataaa ataatatttt cacatatgaa ggtatgtctt catactacag gatttctgac     7500

ttgaatatat tctataatgc tttaattcat taccataaca aatgtactaa gaattaatgt     7560

tgcatcttta gtattccatt ttttggaact gtttttcaaa tgttctatat cctctagctt     7620

attatgctat ctaaaataat ttcagtgtgt tttttcctgg ggcaactgaa tgattcttgt     7680

tttgaatgag tgataaaatg ttttgtgata gtatctaata tttggtcctt tacagaaaaa     7740

atggcttgtg gtactatatt gaaaaaacta ttgtatttcc tcaattttac tgtgtgttgt     7800

cttgtttcta taaacaaaaa taagttttgg aaaaaaaaaa aaaa                      7844


<210>  62
<211>  3850
<212>  DNA
<213>  Homo sapiens

<400>  62
cacacgagag cgagcgaggg agccagcgag agagggaggg agagaaggaa agaagagggg       60

aggggtgggg gcgagaggta aatagtctta aatcggaagg gagctgcttc tctgtggtct      120

tgacaagcgc tgcctgggct ccgccggctc actaataact gagtgacctt ttctttggct      180

gtattatgtc tggctgggaa gggattgcat tttgcagctg agagccggag cttccttcag      240

ctcggctcct cgcacgctgc tggggtaagt tgtcttgaac caggacggag agagacagcc      300

tcggactgca gttgcctaaa aggaggacac ctgtggctca gatgcggtca acaccattgc      360

ttggcgtatc cttgaggacc tcattatttt aaacttaaaa aaaaatagac attccctccc      420

ccgtcttttt tttttttttc aaacaatgct tctttttgac ctttcccaag gagaagcgct      480

acaaagcagc cactgtgctt actgaacggc ctccccctgt atcgcttaat tgagaaggta      540

tacaaatgct ctcagtccag ccagacacca agccgaaagg ttgtgctggc tgcaaccgaa      600

agatcaagga ccggtatctt ctaaaggcac tggacaaata ctggcatgaa gactgcctga      660

agtgtgcctg ctgtgactgt cgcttgggag aggtgggctc caccctgtac actaaagcta      720

atcttatcct ttgtcgcaga gactatctga ggctctttgg tgtaacggga aactgcgctg      780

cctgtagtaa gctcatccct gcctttgaga tggtgatgcg tgccaaggac aatgtttacc      840

acctggactg ctttgcatgt cagctttgta atcagagatt ttgtgttgga gacaaatttt      900

tcctaaagaa taacatgatc ctttgccaga cggactacga ggaaggttta atgaaagaag      960

gttatgcacc ccaggttcgc tgatctatca acatcacccc attaagaata caaagcacta     1020

cattctttta tcttttttgc tccacatgta cataagaatt gacacaggaa cctactgaat     1080

agcgtagata taggaaggca ggatggttat atggaataaa aggcggactg catctgtatg     1140

tagtgaaatt gccccagttc agagttgaat gtttattatt aaagaaaaaa gtaatgtaca     1200

tatggctgga tttttttgct tgctattcgt ttttgtgtca cttggcatga gatgtttatt     1260

ttggactatt gtatataatg tattgtaata tttgaagcac aaatgtaata cagttttatt     1320

gtgttaccat ttgtgttcca tttgcttctt tgtattgttg catttagtac aatcagtgtt     1380

taaacttact gtatatttat gctttctgta tttaccagct attttaaatg agctgtaact     1440

ttctagtaaa gaattgaaaa gcaaatctca ctaatgatac acagatagat aaagcaagtc     1500

tatcaacatt aaaaatacta aaaaataaag acacacacag agcattttag tgacatccac     1560

tacttattgc cgctatgagt tagagtctat cagtgttctt gttataaccc cctattttca     1620

gggggttaaa aatcagcttt aaaaaaatac ataaaaattt catcttaaag cactttcatt     1680

ttataccaac gtgaaaagtg ccatttttag aataacttta aagcttaaca ggtttccttt     1740

taatatcctt tttttgtgtg ctctttactt acacaatggc tttgttttgc tttttcagcc     1800

acacccctta tgtgaactag tgcctttggg tatcacgtaa aattttttcc aaagggttac     1860

tttaaaaatc tgttaccaca attatgagat gatttttaag tgataaatta aacttcttct     1920

tgtataaatt ctgcccagat ctctccacaa gagctgaggg tttcataact ttatggctta     1980

ataaatgtat gacactgaaa agatttgagt gtgaatctac tgaaatcact ataatgcaca     2040

ttgaagctat gatggtattt gagtagtgag gttacttttg atcggagcaa cataatgctc     2100

atagaatctt ctagaagaag agaaacaaag ggattgataa aatgctgaga actagtgatt     2160

atatattttt ctgtatttac ctgacattta ttttaatgtt caaaaagtaa acactttaag     2220

tttgatgtgt tttactctct cattgtttta agtaattgcc aactcagaat acatcattct     2280

taggctgaaa tttgtctttc cattttttaa ggtgaaatag tactacctta cgtgatagca     2340

tacaaagaag aaagctctag aaagagaaat tatggagaat gattatttaa attacaatta     2400

aggaaatgag aatatgatcc cctcttccga gttgcccaca aacttgcttc tttgcttttg     2460

ctccctgtaa tagaactact tttcaacaaa tctaattttg cacggcaccg ttaaccatat     2520

tttcactaca gcaaacttag tgctatgggt tttctttttc tttgtttttt tcttgatcac     2580

ttgtatagga aacaatattt tccagtgtta tttgcatata tattttgtcc ttccaatata     2640

tgcattacag atgaaaatta aatgttatac ctgaattctt gggttggggc caaaatatta     2700

agctgaaaat aatgctggtg tggatttgtt ttaaaacaaa gctttattat gaacatgcat     2760

gtgaatctgg atattgcctc ttatttttaa gaaaatggtt ctgtgaaaag tgaatgatat     2820

gtatttttcc aaatgcttca tggttaggag tcttcaagtt ccatgttccc cagatttgag     2880

atatactaaa gaaagaaatt caaaagtagc tatttggggc ccacaaaaat aactattatt     2940

ttagccttag agccttacac ttgtttcatg aagagaaagg acttgcataa ccaaaataaa     3000

caaagcaaga caaattaaaa atatgtgggg gagagatcag tgaaaagtgg ttttcttaat     3060

gcagccctgc tggtccccat taacaattgc ttgaaattca catggatgta aaattataat     3120

tgtcaggatc ttattcagat gatcttttaa ggtttaactg gttttgcttt tgtttatcta     3180

tatgtcaaaa tacttgtaaa ttgggaacaa acttctctca gcttcttgaa gttgttcaac     3240

tatccttgcc actggaagac caaacaaggt tttcactgct ttttctttta cataatatgc     3300

tgagaattat ttcttatgct ttttactaca aacaaaatta ctcacctgga ttaaagatta     3360

aggccttaat ctgtttagat tatctttaat ctccatgaaa tcgtgaaata agacaagaat     3420

agtgtttcag ctgtaggcca ttttacagct aattgcccat aaattgtagc atttattgac     3480

ctgaagtact aagctaattg tcttgactac tcaaagcccc tgaattgttg tcaactttcc     3540

cctttgtgtt gtgtagccct aacgtcattt agcttgttgt ctgatgcctc cagtaggaca     3600

cctccgatgg agctttgatt tctgagcagc gaaagctccc ttcctaagat gcatctcgca     3660

taggctgcct atgatgaagg accgtgcacc tccactccaa cagagtgctg agtttaaaag     3720

ttgacctgtg tttgtaattt cactttcatc ttgcttaata aatatctgct ggattctttc     3780

attcactttt ttacatttgg atttatgttt ttaataaaag gggtgttaca ctaaaaaaaa     3840

aaaaaaaaaa                                                            3850


<210>  63
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  63
ccacatgtag gcagttcaga ggtgcttccc agggccctgg cgctagtgcc tgtccctcct       60

gctgaagttg cctttcctgg tgtccagtga ttgaattcta aattcagcac atataccaga      120

ggaatacgag ccaaagaagt tgttccagct agagttgctg ggaatccatg aatcaaagac      180

ttgctcagct agttctgtat gtgaaaggaa atgggtgtga ctctgaggaa gcctttttaa      240

ttctgattca ggagatacat aattagatgc cacttgattt tgttccacag actttttgct      300

gaggacttga gagctaaggt tctgtgatcc agaactagtt ccagacttac tcttctggaa      360

atgaacaggg ccctcctgtg cttatttttc caggatactg cattggaaat tgagtcaggg      420

acccattggt gagaagagaa cagtgaacag aatcacattg atctggtcct ggagtttgtc      480

tgacaatttc tacttgaccg caggaggtct gaagattgga aggggcccta ctcaattgtg      540

ctatttttct ctcttttttt tttttttgag acggagttgc ccaggctgga gtgcagcggc      600

atggtctcag ctcactgcaa cctctgcctc ccgggttcaa gcagttctct gcctcagcct      660

cccaagtagc tgggattaca ggtgcctgcc accattcctg gctaattttt gtattttcag      720

tagagacagg gtttcaccat cttggcctgg ctgatcttga actcctgacc tcgtgatcca      780

ccggcctcag cctcccaaag tgctgggatt acagacgtga gccaccgtgc ccggccaatc      840

ctgctatttc tctacaggac aaagggatat ataatctgca acatgccctc catgttggaa      900

cgcattagca aaaatttggt caaagagatt ggaagcaaag acctgacacc tgtcaaatac      960

ctattgagtg ccaccaaatt acgtcagttt gttatattac gaaagaagaa ggattctcgt     1020

tcatcatttt gggaacaatc tgactatgtt ccagttgaat tctccctcaa tgacatcctg     1080

gagccaagtt cttcagtcct agaaactgtt gtgacaggac cgttccactt cagtgacatt     1140

atgatccaga agcataaggc tgacatgggt gtgaatgttg gtatagaagt gagtgtgtca     1200

ggggaggcct ctgtggacca tggatgctcc ctcgagtttc aaattgttac catcccatca     1260

ccaaacctgg aagactttca aaaaaggaaa ctgttggatc cagagccatc atttctgaag     1320

gagtgccgga ggagagggga caacctgtac gtggtgacag aggctgttga actgatcaac     1380

aatactgtgc tgtacgatag cagtagtgtg aatattttag ggaaaattgc tctttggatt     1440

acctatggca agggtcaagg ccaaggagag agtctcagag tgaagaagaa ggcgctgact     1500

cttcagaaag gcatggtgat ggcttataag agaaagcagc tggttatcaa ggagaaagcc     1560

attctcatct cagatgatga tgaacagaga acctttcaag atgagtacga aatttccgaa     1620

atggtaggct actgtgctgc gaggagtgag gggttgctac catcatttca taccatctct     1680

ccaaccctct tcaatgcctc atccaatgat atgaagttaa aaccagagct atttctgaca     1740

cagcaatttt tgagcgggca tttgccaaaa tacgaacaag ttcacatcct cccagtagga     1800

agaatagagg aacccttctg gcaaaatttc aagcatctac aagaggaggt tttccagaaa     1860

ataaagacac tggctcagct ctcaaaggat gttcaggatg tcatgttcta cagtatcctg     1920

gccatgctca gagacagagg ggctctacag gacctgatga acatgctgga attggacagc     1980

tcaggtcatt tggatggccc tggtggtgcc atcctaaaga aacttcaaca ggattcaaac     2040

catgcatggt ttaacccaaa ggaccccatt ctttatctcc ttgaagccat aatggtgctg     2100

agtgacttcc aacacgattt gctggcctgt tccatggaga agaggatcct gcttcagcaa     2160

caggagctgg taaggagcat cctggagcca aacttcagat acccctggag cattcccttc     2220

accctcaaac ctgagctcct cgccccactc cagagtgagg gtttggccat cacctatggc     2280

ctgctggagg agtgtggcct taggatggag ctggataacc ccaggtcaac ctgggatgta     2340

gaagcaaaga tgcccctgtc tgccctctat gggactctct cgttgctgca gcagctggct     2400

gaggcctaag ccctccctga tgggcagtca gtccagagat gctggccctc gcccagtcta     2460

tgctgtgagt gtccttatgg gtgcaagaga tagggctgtg cctctctgcg tttccaggtg     2520

gagtagagac agtaatgggt agagacttta ggaaatgttt tggggtggtg gaatactcta     2580

tatattgaca agagtttata tattgacaag agtttatata tttgtcaaaa ctcctcaaat     2640

agtatgttaa agacgtaagc gtttcactat gtataaattt tacttcaaaa taataaaaac     2700

aaatactgac tctaaaaaaa aaaaaaaaaa a                                    2731


<210>  64
<211>  2899
<212>  DNA
<213>  Homo sapiens

<400>  64
atcatttcct cctcagatta ccaagcaaga acagctaaaa tgaaagccat cattcatctt       60

actcttcttg ctctcctttc tgtaaacaca gccaccaacc aaggcaactc agctgatgct      120

gtaacaacca cagaaactgc gactagtggt cctacagtag ctgcagctga taccactgaa      180

actaatttcc ctgaaactgc tagcaccaca gcaaatacac cttctttccc aacagctact      240

tcacctgctc cccccataat tagtacacat agttcctcca caattcctac acctgctccc      300

cccataatta gtacacatag ttcctccaca attcctatac ctactgctgc agacagtgag      360

tcaaccacaa atgtaaattc attagctacc tctgacataa tcaccgcttc atctccaaat      420

gatggattaa tcacaatggt tccttctgaa acacaaagta acaatgaaat gtcccccacc      480

acagaagaca atcaatcatc agggcctccc actggcaccg ctttattgga gaccagcacc      540

ctaaacagca caggtcccag caatccttgc caagatgatc cctgtgcaga taattcgtta      600

tgtgttaagc tgcataatac aagtttttgc ctgtgtttag aagggtatta ctacaactct      660

tctacatgta agaaaggaaa ggtattccct gggaagattt cagtgacagt atcagaaaca      720

tttgacccag aagagaaaca ttccatggcc tatcaagact tgcatagtga aattactagc      780

ttgtttaaag atgtatttgg cacatctgtt tatggacaga ctgtaattct tactgtaagc      840

acatctctgt caccaagatc tgaaatgcgt gctgatgaca agtttgttaa tgtaacaata      900

gtaacaattt tggcagaaac cacaagtgac aatgagaaga ctgtgactga gaaaattaat      960

aaagcaatta gaagtagctc aagcaacttt ctaaactatg atttgaccct tcggtgtgat     1020

tattatggct gtaaccagac tgcggatgac tgcctcaatg gtttagcatg cgattgcaaa     1080

tctgacctgc aaaggcctaa cccacagagc cctttctgcg ttgcttccag tctcaagtgt     1140

cctgatgcct gcaacgcaca gcacaagcaa tgcttaataa agaagagtgg tggggcccct     1200

gagtgtgcgt gcgtgcccgg ctaccaggaa gatgctaatg ggaactgcca aaagtgtgca     1260

tttggctaca gtggactcga ctgtaaggac aaatttcagc tgatcctcac tattgtgggc     1320

accatcgctg gcattgtcat tctcagcatg ataattgcat tgattgtcac agcaagatca     1380

aataacaaaa cgaagcatat tgaagaagag aacttgattg acgaagactt tcaaaatcta     1440

aaactgcggt cgacaggctt caccaatctt ggagcagaag ggagcgtctt tcctaaggtc     1500

aggataacgg cctccagaga cagccagatg caaaatccct attcaagaca cagcagcatg     1560

ccccgccctg actattagaa tcataagaat gtggaacccg ccatggcccc caaccaatgt     1620

acaagctatt atttagagtg tttagaaaga ctgatggaga agtgagcacc agtaaagatc     1680

tggcctccgg ggtttttctt ccatctgaca tctgccagcc tctctgaatg gaagttgtga     1740

atgtttgcaa cgaatccagc tcacttgcta aataagaatc tatgacatta aatgtagtag     1800

atgctattag cgcttgtcag agaggtggtt ttcttcaatc agtacaaagt actgagacaa     1860

tggttagggt tgttttctta attcttttcc tggtagggca acaagaacca tttccaatct     1920

agaggaaagc tccccagcat tgcttgctcc tgggcaaaca ttgctcttga gttaagtgac     1980

ctaattcccc tgggagacat acgcatcaac tgtggaggtc cgaggggatg agaagggata     2040

cccaccatct ttcaagggtc acaagctcac tctctgacaa gtcagaatag ggacactgct     2100

tctatccctc caatggagag attctggcaa cctttgaaca gcccagagct tgcaacctag     2160

cctcacccaa gaagactgga aagagacata tctctcagct ttttcaggag gcgtgcctgg     2220

gaatccagga actttttgat gctaattaga aggcctggac taaaaatgtc cactatgggg     2280

tgcactctac agtttttgaa atgctaggag gcagaagggg cagagagtaa aaaacatgac     2340

ctggtagaag gaagagaggc aaaggaaact gggtggggag gatcaattag agaggaggca     2400

cctgggatcc accttcttcc ttaggtcccc tcctccatca gcaaaggagc acttctctaa     2460

tcatgccctc ccgaagactg gctgggagaa ggtttaaaaa caaaaaatcc aggagtaaga     2520

gccttaggtc agtttgaaat tggagacaaa ctgtctggca aagggtgcga gagggagctt     2580

gtgctcagga gtccagccgt ccagcctcgg ggtgtaggtt tctgaggtgt gccattgggg     2640

cctcagcctt ctctggtgac agaggctcag ctgtggccac caacacacaa ccacacacac     2700

acaaccacac acacaaatgg gggcaaccac atccagtaca agcttttaca aatgttatta     2760

gtgtcctttt ttatttctaa tgccttgtcc tcttaaaagt tattttattt gttattatta     2820

tttgttcttg actgttaatt gtgaatggta atgcaataaa gtgcctttgt tagatggtga     2880

aaaaaaaaaa aaaaaaaaa                                                  2899


<210>  65
<211>  1841
<212>  DNA
<213>  Homo sapiens

<400>  65
agaatgattt cactacagac tctctggaaa gcctgggagc tgaattccgg aagatcccca       60

catcgatgaa agcaaagcga agccaccaag ccatcatcat gtccacgtcg ctacgagtca      120

gcccatccat ccatggctac cacttcgaca cagcctctcg taagaaagcc gtgggcaaca      180

tctttgaaaa cacagaccaa gaatcactag aaaggctctt cagaaactct ggagacaaga      240

aagcagagga gagagccaag atcatttttg ccatagatca agatgtggag gagaaaacgc      300

gtgccctgat ggccttgaag aagaggacaa aagacaagct tttccagttt ctgaaactgc      360

ggaaatattc catcaaagtt cactgaagag aagaggatgg ataaggacgt tatccaagaa      420

tggacattca aagaccaagt gagtttgtga gattctaaca gatgcagcat tttgctgcta      480

ccttacaagc ttctcttctg tcaggactcc agaggctgga aagggaccgg gactggaaag      540

ggaccaggac tgaacagact ggttacaaag actccaaaca atttcatgcc ctgtgctgtt      600

acagaggaga acaaaatgct ttcagcaagg atttgaaaac tcttccgtcc ctgcaggaaa      660

ggattgatgc tgatagaaga gcctggacag atgtaatgag aactaaagaa aacagatggc      720

tggagatgac atttatccag ggtcactttg tcaggcccta ggacttaaat cgaagttgaa      780

cttttttttt tttttttaac caaatagata ggggaaggga ggagggagag ggaggacagg      840

gagagaaaat accatgcata aattgtttac tgaattttta tatctgagtg ttcaaaatat      900

ttccaagcct gagtattgtc tattggtata gatttttaga aatcaataat tgattattta      960

tttgcactta ttacaatgcc tgaaaaagtg caccacatgg atgttaagta gaaattcaag     1020

aaagtaagat gtcttcagca actcagtaaa accttacgcc accttttggt ttgtaaaagg     1080

ttttttatac atttcaaaca ggttgcacaa aagttaaaat aatggggtct tttataaatc     1140

caaagtactg tgaaaacatt ttacatattt tttaaatctt ctgactaatg ctaaaacgta     1200

atctaattaa atttcataca gttactgcag taagcattag gaagtgaata tgatatacaa     1260

aatagtttat aaagactcta tagtttctat aatttatttt actggcaaat gtcatgcaac     1320

aataataaat tattgtaaac tttgtggctt ttggtctgtg atgcttggtc tcaaaggaaa     1380

aaataagatg gtaaatgttg atatttacaa acttttctaa agatgtgtct ctaacaataa     1440

aagttaattt tagagtagtt ttatattaat taccaaactt tttcaaaaca aattcttacg     1500

tcaaatatct gggaagtttc tctgtcccaa tcttaaaata taaaatatag atatagaagt     1560

tcatagattg actccttggc atttctattt atgtatccat taaggatgag ttttaaaagg     1620

ctttctcttc atacttttga aaaatttctt ctatgattac agtagctatg tacatgtgta     1680

catctatttt tcccaagcaa tatgttttgg gtttagagtc tgagtgatga ccaagattct     1740

gtgtgttact actgtttgtt taataggaac aaatatagaa ataatattat ctctttgctt     1800

atttcccgtt aaaactataa taaaatgttt ctaggacagc a                         1841


<210>  66
<211>  7411
<212>  DNA
<213>  Homo sapiens

<400>  66
ctccagtccg catgctcagt agctgctgcc ggccgggctg cggggcggcg tcccgtgcgc       60

gcctacgggc tgcggtggcg gccgccgcgg cacccggcag ggcccgccag tccccgcttc      120

cctgctccag agccgccgcc tgggccgggg cagggcgggc ccggggctcc tccatgctgc      180

cagccgcggg gctgcggagc cgaccaagtg gctcctgcga tggcggcgga agaggaggct      240

gcggcgggag gtaaagtgtt gagagaggag aaccagtgca ttgctcctgt ggtttccagc      300

cgcgtgagtc cagggacaag accaacagct atggggtctt tcagctcaca catgacagag      360

tttccacgaa aacgcaaagg aagtgattca gacccatccc agtcaggaat catgacagaa      420

aaagtggtgg aaaagctttc tcagaatccc cttacctatc ttctttcaac aaggatagaa      480

atatcagcct ccagtggcag cagagtggaa gatggtgaac accaagttaa aatgaaggcc      540

ttcagagaag ctcatagcca aactgaaaag cggaggagag ataaaatgaa taacctgatt      600

gaagaactgt ctgcaatgat ccctcagtgc aaccccatgg cgcgtaaact ggacaaactt      660

acagttttaa gaatggctgt tcaacacttg agatctttaa aaggcttgac aaattcttat      720

gtgggaagta attatagacc atcatttctt caggataatg agctcagaca tttaatcctt      780

aagactgcag aaggcttctt atttgtggtt ggatgtgaaa gaggaaaaat tctcttcgtt      840

tctaagtcag tctccaaaat acttaattat gatcaggcta gtttgactgg acaaagctta      900

tttgacttct tacatccaaa agatgttgcc aaagtaaagg aacaactttc ttcttttgat      960

atttcaccaa gagaaaagct aatagatgcc aaaactggtt tgcaagttca cagtaatctc     1020

cacgctggaa ggacacgtgt gtattctggc tcaagacgat cttttttctg tcggataaag     1080

agttgtaaaa tctctgtcaa agaagagcat ggatgcttac ccaactcaaa gaagaaagag     1140

cacagaaaat tctatactat ccattgcact ggttacttga gaagctggcc tccaaatatt     1200

gttggaatgg aagaagaaag gaacagtaag aaagacaaca gtaattttac ctgccttgtg     1260

gccattggaa gattacagcc atatattgtt ccacagaaca gtggagagat taatgtgaaa     1320

ccaactgaat ttataacccg gtttgcagtg aatggaaaat ttgtctatgt agatcaaagg     1380

gcaacagcga ttttaggata tctgcctcag gaacttttgg gaacttcttg ttatgaatat     1440

tttcatcaag atgaccacaa taatttgact gacaagcaca aagcagttct acagagtaag     1500

gagaaaatac ttacagattc ctacaaattc agagcaaaag atggctcttt tgtaacttta     1560

aaaagccaat ggtttagttt cacaaatcct tggacaaaag aactggaata tattgtatct     1620

gtcaacactt tagttttggg acatagtgag cctggagaag catcattttt accttgtagc     1680

tctcaatcat cagaagaatc ctctagacag tcctgtatga gtgtacctgg aatgtctact     1740

ggaacagtac ttggtgctgg tagtattgga acagatattg caaatgaaat tctggattta     1800

cagaggttac agtcttcttc ataccttgat gattcgagtc caacaggttt aatgaaagat     1860

actcatactg taaactgcag gagtatgtca aataaggagt tgtttccacc aagtccttct     1920

gaaatggggg agctagaggc taccaggcaa aaccagagta ctgttgctgt ccacagccat     1980

gagccactcc tcagtgatgg tgcacagttg gatttcgatg ccctatgtga caatgatgac     2040

acagccatgg ctgcatttat gaattactta gaagcagagg ggggcctggg agaccctggg     2100

gacttcagtg acatccagtg gaccctctag cctttgattt ttaactccaa aaatgagaaa     2160

cattttaaag catttcattt acgaaaaact gtctcaacta ttcttaagta ctgtattgat     2220

attgtttgta tcttttatta atgttctacc actttttata gatttgcatc ttcctgtcac     2280

agggatgtgg ggaaatacgt tttcctccca agagaaccaa gtttattata gactccttta     2340

ttcagtgaaa tggcttataa tccactagtt gccatatttt tgctaaaata tttctaacca     2400

agaatactac ttacatattg ttttggcttt gttttatttt tgatgcagtt ttttttagtt     2460

gaggtaatgt aatatattga tgttttcctt tgtgtctaag attcatttat aatagtaggt     2520

ttgtataatt tggaacattt tccattcctt gcgaatttcc ttaattgagg atagggctta     2580

cacactttaa gaaaacagtg agtacttgaa catttaaagg gacagtgcaa tttatagtca     2640

taatcacatt gaatactgta tttgatcttt ggagacttag gcaagcacag agctgggata     2700

tttatgctca gttgagcact ttaagatgaa ttttaagtga gatgatttct tgcttaaaac     2760

tcagaaagtc aaaagagttt cagctttcct tacagaaaag gaaggatctt gggccctaga     2820

tcttggggat taacctctgc atataagatt tactcttaat aggccagacg tggtggctca     2880

cgcctgtaat cccagtactt tgggaggctg agacgggcag atcacttgag gtcaggagtt     2940

caagaccagc ctggccaata tggtgaaacc ccgtttctac taaaaataca aaaaaaatta     3000

cccaggcact cactcttgag gtaactaacc aactcccacg ataatgacag tccattcatg     3060

agcgcaaagg cctcatgacc taatggcaca cacctgtaat cccaactgct tgggaggctg     3120

aggcgagagg attgcttgaa cctgggaggc agaggttgca gtgagccgag atcgcaccac     3180

tgcactccag tctgggcaac agagtgagac ttcatctcaa aaaaagtaaa aaaaaagatt     3240

taatataatc actgaagatc tctattatag atagattagg tttttgacat tggaaacata     3300

cttagggata gatttgtcct aaaggaaaaa agtaggcccg ggcagattaa atgtcttgtg     3360

taaagtcaca cattaaattc agtcacacat taaattcata gagttttaaa tgtttaatgt     3420

atataaacca gtttctttat acacatttgg gaaaacattg gtctcacaga ttaaatgatt     3480

aactaactga cccaggaact agttgtagct ttctaagtaa ttaggcaatt acagttattg     3540

cctgtaacca aaggtaataa aacaaaatga caagtacatg tttaaaatta tgaggcaatg     3600

agaaataatt taaaaaccaa ttttctagtt ataatttaaa atttggagag catttttaac     3660

agtaattaat ccagaggtgg ctcaaattga gtataagaat taagattatt taaaatactg     3720

catgtctacc ttctcgggga tcatacttta taacactttc tgcttcagta gctcttcata     3780

gcttgccaag tatgctccca tattttctct ctcgtgcctc gcaaatgaaa gtcagatagg     3840

ctgggaactc atggggcagc cctcagactt caatgtgggc ttcaaatcca gtttcctgtt     3900

ctatatggtg ctacatcttt ccagaaaatt tccctcagag cccctcgcca aaacaaagca     3960

ttattttgac cctgcatgct atttctttag ctgtaggtga tagattagaa cttctgtcag     4020

acatgttaat gacaaacata ccaacagaca ataaccaaaa gcaaatgttt ccttcaagtg     4080

tgaaatgtgc aggggcttcg tgggcaagga tgtattggca cactgtcctc ttgaactgat     4140

agtgtcccag caatgttgga gggttggcac cattcctggt ccgacacttg aggacctgag     4200

agacatcagg tttagaatga gccaaagaaa tcctacaaga tggggagaat tggtgtgcag     4260

cagcctaagt gttatagtta agtctaaaga agtatgaaag atcccctgtg ttctctaaat     4320

tgagcagagg ggcctgccta ccaatatcac tttttagggg actgaaccat tgcaggttag     4380

acttggcttc caaagagtct gcctaagcca ggggtggcag ggtaggccat catagctgga     4440

tggcctcaaa agcagatggg ggcagacttg ccctcgtgat gccaggattt gagaggcaga     4500

gtttctagag ggagaccagt gctgcctctc acagtggcag ttttttctct ttgcaagagg     4560

aggggctgtt caattccata gaccagtggg cagatagcca gttgaatact ctgtgcatgg     4620

tttgatcctt tattagttcg ctctaatatt tttctgtaga tccttttgtc ctggactcaa     4680

aatctaatcc atgcattgta tgataccgta gctctcctaa ggtttgtgtt tccttcaaaa     4740

tgttttagtt ttcttcaact aaatttgatt tttgctgtta gaagtgacat atttttatgg     4800

tatacactat gttccttttt tctactgcga gtcaattttt tgaattttcg tgagaaagaa     4860

tatatctaca aattgcacga aagtatcata aaaacagtac tctagacttt tcttttcttt     4920

tctttttttt tttttttttt tttttgagat ggagtctcgc tctatcgccc aggctggagt     4980

gcagtggcgc gatcttggct cactgccatc tctgcctcct gggttcacgc cattctgcct     5040

cagcctccag agcagctggg accacaggcg cccgccacca cacctggcta attttgcttt     5100

gtattttcag tagagacggg gtttcaccat gttagccagg atggtctcga tctcctgacc     5160

tcgtgatccg cccacttcgg cctcccaaag tgctgggatt acaggcatga gccactgcgc     5220

ccggcctact ctacactttt tttaacccta agaattacca ctacagtaat gtagtggagt     5280

gggaagagtg cctggaatca gaagaccctg ttgaggctga atttagctgt atgacctcat     5340

gcaagccatt taaactctgt gcctcagcgt cctcattttt aaaaggaggt ttgatctcta     5400

tgtttacttc cagctctgat tctgggattc taatccacag gacttgggtg ttagggtgga     5460

acctagaact gtgctgtcca gtgcagtagc cactagccac atgtggctac tgagcacttg     5520

caatgtggct agtacaaagt gagatgtgct atcaatgtaa gatacatacc agattttgaa     5580

gactagtatt accaaaagaa tgtaaaatat cacattaata attttatatt aattacatgt     5640

tcaaatgata ttttggatat actgaattaa aacattaaaa ttagttctac ttgtatcttt     5700

ttactttttt aatgtggcta gaagaaaata aaattataca tgtggctcag attatatttc     5760

tattggacag cgctgctcta gaacattata ttaagtggtt attattgaag tagaccaaag     5820

tttataccat aaggatattt ttccttaaat accatgtttg aagaacaatt atttattgat     5880

ccttgaatct gtaagatcaa ataacaagtc tctatccatg ttaccaaatt taaacttttg     5940

aaaataataa actttaaaat atcagatgtg ttattacagg atgatacttg gaatcaagtg     6000

aaatgagtta tatggtcatc actaaattta gaaatctatt gtgaaacaaa gacaaacagg     6060

aaagtacaga atagagactt ttagtaaata aatggaattt aaaagaaagt gtttatttac     6120

agtgtcacga cagaaaagga tgtctttgtt gtcatagtct ttgagggatc tccgtaaaat     6180

ctggggcaca ggtacaagaa atagccaata tttagttccc agaccatgtt tagtagtgtc     6240

cagtttcaga tcatgctgcc aagaggtatc tccccctcag gtgggtcatc actgagccct     6300

ggaattggag actcatactt gcccagcaca atgttacggg cagacaggcc gacatctatg     6360

attagctaga agccataaag aaaagctgct aagtggccac taggtgccac ttttctgttt     6420

ttgtaatgct ttcattagca gatctttttt ttccaagctc catggggcct atgagaggca     6480

tttatgattt ttgtgcctac aataagtcag cctgtctggt gtgagttgtt ttatgagaaa     6540

tgctttccaa gggaggtcta ggaagatcct gacacataag aactttggct tagagagctt     6600

tccaggtgta gtgccaataa aaactgacct ggaaagaaaa cctgcccagc acggaacatg     6660

ctttctgaac tcacttgaga gtgtatggtg tatgtcactt ctcatatatt cttgagttta     6720

gatttgtctt ttatacaatt tttagctctt ttccagttca cttgtgctcg tctgtatatt     6780

ggtattttta aatttttgtg gtaaataatg aaaagagtga aattatattt tataattact     6840

catttgtagt tttttttttt aatttaataa acttcctcca aaaagtgctc ccttaactac     6900

tttctaatgt ggaaacatag attaaggaaa ccatccagtg ccctcaaacc actgggcaga     6960

ggggtacatt gaactctgtt actatatata tttctgggta tgttccccag ggtatactaa     7020

ctgctgtaac aactccaaaa tctcagtggt ttaaccagta aaggtttcct tgtgctcacg     7080

tcagactcca acgtcatcag ccttatctgt ccctctgact ctctcctcct ccctttctgc     7140

ctcttcctca ttccatccct cagctttgct ttcctatgag ctggttttat cttccggtgg     7200

accctctccg cataatgaca ctcagaagtt ccaagcgtat attgttctta tacctgacaa     7260

tttcagtgga aagagagcct ctctatttcc tagtaattca catgcacata tgcattgact     7320

gggcctctgg atcaacttgg tttacctgga ctttctgttg tgtggttgca gtatctacac     7380

taattctaga gagtcaacca tcatgaatta t                                    7411


<210>  67
<211>  5360
<212>  DNA
<213>  Homo sapiens

<400>  67
gccccgcagt ttccgcgcta agggaacgag tgcgcggagg ggacgagcgg ctggaccaca       60

gccggcgccc gatcaggatc tccgcgctgg gatcggtgga acttgaggca gcggcggcgc      120

ggggcgccat ggcacaccga gcggctccgt cttctgctcc tcagagagcc cggctggcgg      180

cctgggatga caagatgtct ggactgcaat cctgcacagt tttgagaggg agatgacttg      240

agtggttggc ttttatctcc acaacaatgt ccatgaacaa ttccaaacag ctagtgtctc      300

ctgcagctgc gcttctttca aacacaacct gccagacgga aaaccggctt tccgtatttt      360

tttcagtaat cttcatgaca gtgggaatct tgtcaaacag ccttgccatc gccattctca      420

tgaaggcata tcagagattt agacagaagt ccaaggcatc gtttctgctt ttggccagtg      480

gcctggtaat cactgatttc tttggccatc tcatcaatgg agccatagca gtatttgtat      540

atgcttctga taaagaatgg atccgctttg accaatcaaa tgtcctttgc agtatttttg      600

gtatctgcat ggtgttttct ggtctgtgcc cacttcttct aggcagtgtg atggccattg      660

agcggtgtat tggagtcaca aaaccaatat ttcattctac gaaaattaca tccaaacatg      720

tgaaaatgat gttaagtggt gtgtgcttgt ttgctgtttt catagctttg ctgcccatcc      780

ttggacatcg agactataaa attcaggcgt cgaggacctg gtgtttctac aacacagaag      840

acatcaaaga ctgggaagat agattttatc ttctactttt ttcttttctg gggctcttag      900

cccttggtgt ttcattgttg tgcaatgcaa tcacaggaat tacactttta agagttaaat      960

ttaaaagtca gcagcacaga caaggcagat ctcatcattt ggaaatggta atccagctcc     1020

tggcgataat gtgtgtctcc tgtatttgtt ggagcccatt tctggttaca atggccaaca     1080

ttggaataaa tggaaatcat tctctggaaa cctgtgaaac aacacttttt gctctccgaa     1140

tggcaacatg gaatcaaatc ttagatcctt gggtatatat tcttctacga aaggctgtcc     1200

ttaagaatct ctataagctt gccagtcaat gctgtggagt gcatgtcatc agcttacata     1260

tttgggagct tagttccatt aaaaattcct taaaggttgc tgctatttct gagtcaccag     1320

ttgcagagaa atcagcaagc acctagctta ataggacagt aaatctgtgt ggggctagaa     1380

caaaattaag acatgtttgg caatatttca gttagttaaa tacctgtagc ctaactggaa     1440

aattcaggct tcatcatgta gtttgaagat actattgtca gattcaggtt ttgaaatttg     1500

tcaaataaac aggataactg tacatttttc acttgttttt gccaatggga ggtagacaca     1560

ataaaataat gccatgggag tcacactgaa agcaattttg agcttatctg tcttatttat     1620

gctttgagtg aatcatctgt tgaggtctaa tgcctttact tggcctattt gccagagaac     1680

atcttaatgc agcctgcata gtgaaatggt tattttgaga tcaccgctct gtagctaacc     1740

cttataaact aggctcagta aaataaagca ctcttatttt ttgatctggc ctattttgcc     1800

cctcattgtg tagcctcaat taacacatgc atggtcatga cacccagaat tcatgatggt     1860

ttgttataac aacctctgca tattccaggt ctggcagaca ggttgcctga ccctgcaatc     1920

ctatctagaa tgggcccatt cttgtcatat ttgacaaata ggactgccta catttattat     1980

tatgaaggtc gattgttgtt ggaagtgttt tttcatgtca tagattagca attttcaaat     2040

aattattttt tctctgaaaa ttttgtgtgt gattgcacaa taaataattt ttagagaaac     2100

aaaggctctt tctcagcaca ttgatgggca actagaatta cagcagtttc aaaactctac     2160

catggataat gcaaacaaac cgaagctaca tgccaatgat aggtgcaaag aatattggca     2220

aaaggtgctt taccttgagc cattatttgt gtcagagaac aaaagaaaca gaatcaatat     2280

ataaaattca aagactatct gcagctagtg tgtttcttct ttacacacat atacacacag     2340

acatcagaaa attctgttga gagcaggttc attaaatttg taagatggca tattctaaag     2400

cctgtgctac cagtactaag aggggaagac tggcaatttg ccaagcactt ggggattatt     2460

ataacaatta actaggagat caagagataa taatctctcc ccaaattttc caataataat     2520

tgagactttt tctttgcttg tttgtgtaat tcaaccaaaa gaatttcaat acccattcaa     2580

attgtcctag gtctatcaga aattagggaa ggtagtcctg ctttataata ggaaaatgta     2640

tttctgtata agagttcttt gctttcatta acttggattc atttaaaaat taatcttccc     2700

tgttaggctg atttcagatt ctctaggaaa tctgtgtaag taaccagaag acctttcaga     2760

tggtttattt gctttcagca gagaatttat ttcatacagt tacttaagag tgttgatgtc     2820

ttgtgaacag agatataagg aaccattctc catccttcct tatcatgctg ggtacaatgc     2880

ttctatgaat atttccatgt attttgactg gggagaggca tggagaagaa actctcattc     2940

aggggctcca ggatccttct ccttgaggct tctaaataaa tggcagaatt cttgctgtat     3000

tgccatgatg tcaccctggc catgtgtact gacttgagga gatcttgcaa catggccatg     3060

tgcaaggctt taaggagtga gagagatgtg tacatatctt aggagggtta tctatgttat     3120

ctgagtatat gtttgggtaa ccaaattggt cttaaaaatg atgttaaccc aagaagtaga     3180

catcaaaaat taaaaaaaaa aaaaggaatg tgttttcatt gttttaagtt tttcttctga     3240

gtaaaacaaa attatagaaa acaaatgcaa caatgtgcac atctgactta agagtttcat     3300

ttctgttatt atatgtgttg catgtagctt ggcgatttac tgtgtaatga ataatagact     3360

ggaacatcta ccaataactt tcacataaat gttcaaaata gaagtgtatt ttttcaggtt     3420

tctggaaata aatagtaaaa taaatggcac aaatagtttc aataaattta ccaatttgag     3480

tgttttcagc tctatttcaa aactcataac taatcttcag aattactgaa tttccttttg     3540

aactgggtaa ggcattatcc aagcaacttc acatactatt taaacatgat ttctcggtaa     3600

ttatatattc tgggcaaata acataaacat gtcaggattt ttacaggtgt tagtgaattt     3660

ttctaaaaag atgagacaaa agcaaaaata tcacacatag gtttttatga ctatgaatac     3720

aaagataatg ctgattcaca attagctatg ggtaagtcca aaacatcaga ccttttactg     3780

atgggttaac taggtgaaag aaatgggccc ttattttttt ttttccctag aggcagaaag     3840

ttacttctaa tgatctatat agctaaaacg aaaaatacct gaaagttaat acatacatat     3900

gtagatatat tttgttatgt gataaatgtt tcttgtttgc acacttttgg acttgagaaa     3960

tctgcttttg ttttgtgcct actctgagtt tagaacccaa ataagaggac ttgttaaata     4020

tagagtgtac tttttgttaa aactattgct agcttcacct gtataccatc attgttccaa     4080

attaaataac tgttttgggt cagaatataa atgctgggaa tatacatttt attacttctt     4140

aatctgggtg tcaaagattt taccacctgg taaataatgt tggacttcaa cttgttactg     4200

gcacatttta atagtagatg aaacatgttt ttcttggtta tgtgaataaa tgtatgttgt     4260

gctcttcata cttgttggat tgtatagaga ttaaatagtg atatgtatat tttgttgttt     4320

gctttggtat gcaactcatg taattttagt gctttgacta gcttaaaact tcaaacaagt     4380

aattttataa taaagttgga ctaatgtttt tcaagagtga ttatttttag aaggaccata     4440

taaaacttga aacgcttgaa cctaaactcc cgttttatct gctactggat gagaagaatt     4500

tcaacttaat ttccattatt accttttgct ctcccaccct gcccaatctt ctgtgatatc     4560

ttctctcttt tacctgtgtc tcaacttacc taggcaagtc ataatttaga tagaaatctg     4620

atttcccaaa cctccaggtt tagatatatc attcagaaaa gcctcaatgt gtctgtaata     4680

agaaacaatc tccaaattac agcgccataa acttcacaaa agtttgtatc tcccacatgg     4740

ttcctgtcca ctctgaaggg gagctctgct gttgtaatca ctcagagaac tcaggtgaaa     4800

aaacagccac cattatatgt ggctgtttct caaactacag agcatggtga atcacacaca     4860

ggctgttaga atatccatct ggaggcaaca cacatttgca tacacttctc cagctaacat     4920

aaataatgtg gctttactaa cttcccaggg ggcagctaag tgcaatacta tatgttagga     4980

aaacggaaac taatttgtag acagcactaa tgatttccac attaggtaaa aaaaattttc     5040

attcttgtct tcctaatagc atttaaacag aaacgatttt taaaagttgt tttaaacatt     5100

tagaaacatc atggcataga aacatttagg actcactctt tgtaagtact gacaagcatg     5160

gtcttgtaat ctgtaaagat aaggtagaat aaatgaacta aaagaaattt tagatgacta     5220

aaaggactat ataatagaaa gagggaaatc ttggttctta aaaattcagg caattgaaac     5280

atttctgtat aataccaagc attgttgcag tattgtctga aatggttgct tttctaataa     5340

atgaaaatga ctaaaatgta                                                 5360


<210>  68
<211>  4507
<212>  DNA
<213>  Homo sapiens

<400>  68
gaccaattgt catacgactt gcagtgagcg tcaggagcac gtccaggaac tcctcagcag       60

cgcctccttc agctccacag ccagacgccc tcagacagca aagcctaccc ccgcgccgcg      120

ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct gtgcgcggtc ctggcgctca      180

gccatacagc aaatccttgc tgttcccacc catgtcaaaa ccgaggtgta tgtatgagtg      240

tgggatttga ccagtataag tgcgattgta cccggacagg attctatgga gaaaactgct      300

caacaccgga atttttgaca agaataaaat tatttctgaa acccactcca aacacagtgc      360

actacatact tacccacttc aagggatttt ggaacgttgt gaataacatt cccttccttc      420

gaaatgcaat tatgagttat gtgttgacat ccagatcaca tttgattgac agtccaccaa      480

cttacaatgc tgactatggc tacaaaagct gggaagcctt ctctaacctc tcctattata      540

ctagagccct tcctcctgtg cctgatgatt gcccgactcc cttgggtgtc aaaggtaaaa      600

agcagcttcc tgattcaaat gagattgtgg aaaaattgct tctaagaaga aagttcatcc      660

ctgatcccca gggctcaaac atgatgtttg cattctttgc ccagcacttc acgcatcagt      720

ttttcaagac agatcataag cgagggccag ctttcaccaa cgggctgggc catggggtgg      780

acttaaatca tatttacggt gaaactctgg ctagacagcg taaactgcgc cttttcaagg      840

atggaaaaat gaaatatcag ataattgatg gagagatgta tcctcccaca gtcaaagata      900

ctcaggcaga gatgatctac cctcctcaag tccctgagca tctacggttt gctgtggggc      960

aggaggtctt tggtctggtg cctggtctga tgatgtatgc cacaatctgg ctgcgggaac     1020

acaacagagt atgcgatgtg cttaaacagg agcatcctga atggggtgat gagcagttgt     1080

tccagacaag caggctaata ctgataggag agactattaa gattgtgatt gaagattatg     1140

tgcaacactt gagtggctat cacttcaaac tgaaatttga cccagaacta cttttcaaca     1200

aacaattcca gtaccaaaat cgtattgctg ctgaatttaa caccctctat cactggcatc     1260

cccttctgcc tgacaccttt caaattcatg accagaaata caactatcaa cagtttatct     1320

acaacaactc tatattgctg gaacatggaa ttacccagtt tgttgaatca ttcaccaggc     1380

aaattgctgg cagggttgct ggtggtagga atgttccacc cgcagtacag aaagtatcac     1440

aggcttccat tgaccagagc aggcagatga aataccagtc ttttaatgag taccgcaaac     1500

gctttatgct gaagccctat gaatcatttg aagaacttac aggagaaaag gaaatgtctg     1560

cagagttgga agcactctat ggtgacatcg atgctgtgga gctgtatcct gcccttctgg     1620

tagaaaagcc tcggccagat gccatctttg gtgaaaccat ggtagaagtt ggagcaccat     1680

tctccttgaa aggacttatg ggtaatgtta tatgttctcc tgcctactgg aagccaagca     1740

cttttggtgg agaagtgggt tttcaaatca tcaacactgc ctcaattcag tctctcatct     1800

gcaataacgt gaagggctgt ccctttactt cattcagtgt tccagatcca gagctcatta     1860

aaacagtcac catcaatgca agttcttccc gctccggact agatgatatc aatcccacag     1920

tactactaaa agaacgttcg actgaactgt agaagtctaa tgatcatatt tatttattta     1980

tatgaaccat gtctattaat ttaattattt aataatattt atattaaact ccttatgtta     2040

cttaacatct tctgtaacag aagtcagtac tcctgttgcg gagaaaggag tcatacttgt     2100

gaagactttt atgtcactac tctaaagatt ttgctgttgc tgttaagttt ggaaaacagt     2160

ttttattctg ttttataaac cagagagaaa tgagttttga cgtcttttta cttgaatttc     2220

aacttatatt ataagaacga aagtaaagat gtttgaatac ttaaacactg tcacaagatg     2280

gcaaaatgct gaaagttttt acactgtcga tgtttccaat gcatcttcca tgatgcatta     2340

gaagtaacta atgtttgaaa ttttaaagta cttttggtta tttttctgtc atcaaacaaa     2400

aacaggtatc agtgcattat taaatgaata tttaaattag acattaccag taatttcatg     2460

tctacttttt aaaatcagca atgaaacaat aatttgaaat ttctaaattc atagggtaga     2520

atcacctgta aaagcttgtt tgatttctta aagttattaa acttgtacat ataccaaaaa     2580

gaagctgtct tggatttaaa tctgtaaaat cagtagaaat tttactacaa ttgcttgtta     2640

aaatatttta taagtgatgt tcctttttca ccaagagtat aaaccttttt agtgtgactg     2700

ttaaaacttc cttttaaatc aaaatgccaa atttattaag gtggtggagc cactgcagtg     2760

ttatcttaaa ataagaatat tttgttgaga tattccagaa tttgtttata tggctggtaa     2820

catgtaaaat ctatatcagc aaaagggtct acctttaaaa taagcaataa caaagaagaa     2880

aaccaaatta ttgttcaaat ttaggtttaa acttttgaag caaacttttt tttatccttg     2940

tgcactgcag gcctggtact cagattttgc tatgaggtta atgaagtacc aagctgtgct     3000

tgaataatga tatgttttct cagattttct gttgtacagt ttaatttagc agtccatatc     3060

acattgcaaa agtagcaatg acctcataaa atacctcttc aaaatgctta aattcatttc     3120

acacattaat tttatctcag tcttgaagcc aattcagtag gtgcattgga atcaagcctg     3180

gctacctgca tgctgttcct tttcttttct tcttttagcc attttgctaa gagacacagt     3240

cttctcatca cttcgtttct cctattttgt tttactagtt ttaagatcag agttcacttt     3300

ctttggactc tgcctatatt ttcttacctg aacttttgca agttttcagg taaacctcag     3360

ctcaggactg ctatttagct cctcttaaga agattaaaag agaaaaaaaa aggccctttt     3420

aaaaatagta tacacttatt ttaagtgaaa agcagagaat tttatttata gctaatttta     3480

gctatctgta accaagatgg atgcaaagag gctagtgcct cagagagaac tgtacggggt     3540

ttgtgactgg aaaaagttac gttcccattc taattaatgc cctttcttat ttaaaaacaa     3600

aaccaaatga tatctaagta gttctcagca ataataataa tgacgataat acttcttttc     3660

cacatctcat tgtcactgac atttaatggt actgtatatt acttaattta ttgaagatta     3720

ttatttatgt cttattagga cactatggtt ataaactgtg tttaagccta caatcattga     3780

tttttttttg ttatgtcaca atcagtatat cttctttggg gttacctctc tgaatattat     3840

gtaaacaatc caaagaaatg attgtattaa gatttgtgaa taaattttta gaaatctgat     3900

tggcatattg agatatttaa ggttgaatgt ttgtccttag gataggccta tgtgctagcc     3960

cacaaagaat attgtctcat tagcctgaat gtgccataag actgaccttt taaaatgttt     4020

tgagggatct gtggatgctt cgttaatttg ttcagccaca atttattgag aaaatattct     4080

gtgtcaagca ctgtgggttt taatattttt aaatcaaacg ctgattacag ataatagtat     4140

ttatataaat aattgaaaaa aattttcttt tgggaagagg gagaaaatga aataaatatc     4200

attaaagata actcaggaga atcttcttta caattttacg tttagaatgt ttaaggttaa     4260

gaaagaaata gtcaatatgc ttgtataaaa cactgttcac tgtttttttt aaaaaaaaaa     4320

cttgatttgt tattaacatt gatctgctga caaaacctgg gaatttgggt tgtgtatgcg     4380

aatgtttcag tgcctcagac aaatgtgtat ttaacttatg taaaagataa gtctggaaat     4440

aaatgtctgt ttatttttgt actatttaaa aattgacaga tcttttctga agaaaaaaaa     4500

aaaaaaa                                                               4507


<210>  69
<211>  3868
<212>  DNA
<213>  Homo sapiens

<400>  69
gggccgtgct cttgctcccg ccgcctggca gcctcacgct cggctccagc ggccaagagc       60

cggagaaagt cctgctggtg ggcggccgcg gggctgaggg cgtccggcat cccggggccg      120

ctccggcccg ggcggcgaga gtgcccggcg gtccatgcat ccgccgccgc ccgccgccgc      180

gatggatttc agtcagaaca gcctgttcgg ttacatggag gacctgcagg agctcaccat      240

catcgagagg ccggtccgcc ggagcctcaa gacaccggaa gaaatagaaa gattgacagt      300

cgatgaagac ctcagtgata ttgaaagggc tgtttatctg ctcagtgctg gtcaagatgt      360

ccaaggaaca agtgtgattg caaatctccc atttttgatg cgacagaatc ccactgagac      420

gcttcggaga gtgttgccaa aagtcagaga agccctgcat gttgcaggag tggaaatgca      480

gttaacggct gcgatgtcat ttctgaccat tctgcaggac gaatcagtgt caattcatgc      540

atatacccac tcattcctcc aagtcattct cctgcatctg gagcacaggg acacaggtgt      600

cagcaatgca tggctggaaa ctcttctgtc tgttatagaa gtattgccaa aagaaaccct      660

acggcatgag attttgaatc cacttgtttc caaggcacaa ctttcccaaa cagtccagtc      720

tcgtttagtt agttgtaaaa ttttaggaaa attgaccaac aaatttgatg cccacaccat      780

taagcgagaa atacttcctc tggtaaaatc actctgtcaa gatgtagaat atgaagttcg      840

atcttgtatg tgtcggcaat tagaaaatat agcccagggc attgggacag aacttacaaa      900

aagtgtggtg ctccctgaat taatagaact ttctagggat gaaggcagca gtgtacgact      960

tgcagctttt gaaactttgg ttaatctgct tgatatattt gatacagatg acagaagtca     1020

aactatactt cccttagtga aatcattttg tgaaaaatct ttcaaagcag atgaatcaat     1080

tcttatttct ttatctttcc atttaggaaa actatgtcat ggactatatg gaattttcac     1140

tccagatcag cacttgagat ttttggaatt ttataagaaa ctttgtacat tgggtttgca     1200

acaagaaaat ggacacaatg aaaaccagat tccaccccaa atcctagagc aggagaagaa     1260

atatatttca gtacggaaga actgtgctta taactttccg gccatgattg tttttgttga     1320

tcctaaaaac ttccacatgg aactctattc tacattcttc tgcctttgcc atgaccctga     1380

agtaccagtc agatacacta ttgctatttg cttttatgaa gtatctaagc ttctgaattc     1440

tggagtatat ttaatacata aagaactaat aacattatta caagatgaat cactggaggt     1500

actagatgct cttatagatc atcttccaga aatcttggaa cttatgtcta ctggtggaga     1560

aagcagtgtt caagaaaata agttatcttc tctgcctgac ttgattccag cactcacagc     1620

tgctgaacag cgagctgcag cctctttaaa atggagaact catgagaagc tacttcagaa     1680

atatgcctgc ctgccacatg tcatatcaag cgatcagatt tattaccgtt tcttacaaag     1740

aatgttcaca atcatgatga caaataatgt tttacctgtc caaaaggcgg cttcacgaac     1800

tctatgcatt tttctgcgtt ataatcgtaa acaagaacag agacatgagg tcattcaaaa     1860

attaattgaa caattgggcc aaggaaaaag ttactggaat agacttcgat ttttggatac     1920

ctgtgaattt attatagaga tattttcaaa atcatttttc tgtaaatatt tctttctacc     1980

tgctattgaa ctgacacatg atccagtagc aaatgtgaga atgaaacttt gctacctgtt     2040

gcccaaagtg aaatctactc tgaagattcc tgctgataag catctacttc agcagttaga     2100

aatgtgtgtg aggaaactcc tgtgtcaaga aaaagataaa gatgttctgg ctattgtaaa     2160

aagaactgta ttagagttgg acagaatgga aatgtctatg gatgcttttc agaaaaagtt     2220

ttatgagaaa gatttgttgg atcaagagaa agaaagagaa gaactacttc ttttggaaat     2280

ggaacaatta gagaaagaaa agcaacagaa tgatggaagg cccatgagtg ataaaatgtt     2340

tgaaaagaaa cgtagagaca ctaagacacc aacgcaaagt ctgcccaaga acatccccat     2400

ttctgttcct ggaccctctt ctgtcacccc atcgacaagt aaagaaatca agaaatccaa     2460

actgattcga agccagtctt ttaataatca agcttttcat gcaaaatatg gcaacttaga     2520

gaaatgtgct agtaaaagtt ctacaacagg atatacaact tctgtctcag ggttaggaaa     2580

gacttctgtg ctttcactag ctgatgattc attccggact cgtaatgcca gtagcgttcc     2640

atcttccttt tctcctaata ctcccttacc gagtacttcc cgtgggacag gtaactcagt     2700

tgaccccaag agcagtggaa gtaaagatac acaaccacgg aaggctacct taaaatccag     2760

aaaatccaat ccttaaatca actgcttgat gaaggaggca aaacaaaggc agcaggagat     2820

aatgtgattg gtacacaaaa gctaaagcag tggctggggc tttgttttta aattttgggt     2880

tttttttttt gttgttgtta atgagcagaa agagagacat aatgacagct gatgttaaac     2940

ttttcatatt tcaaattaga ttccctagga ggtataatat atatttcttg agtaataatg     3000

tggttacgga attccaatgt tatagtgaag tgtaatgaaa aacatctcta ggaatgtgct     3060

ttaaccactg ctgcaaaaga gacaagtctg catttatttg tgcaggaaac cagccattta     3120

attgttctag agttttagca tttaaaaatc gtatgaaagt ctacatcagc tgaattgtcc     3180

tagcttgata agcacttgga gggggacttg gaaggtgaga aagatactgc attttctcat     3240

gagtctccaa gcccacttga aaagtcacac tgaaaggatg caaatagccg tctgcgattt     3300

tggcggccct ccggattgtg gtgacaatat gttgtacccg gacattccca aatttaaatt     3360

tggcagtgaa aattccacaa agatttctgg taactttgag ctataaatac cttaaaaata     3420

atagattgat gattttcttt atttcctaga gaatttattt tataaatact ttgtttacat     3480

tttagattgt acttgtcttt atttaaaatg atgaatctag tctgaatcag ctgttattcc     3540

aagctatcat gcttaagcta tgtcaacagc atttatttgt actaatgcta atatttccat     3600

caaaatttgc ctgtggaata tatacagttc ttaattttaa actgtcagtt cttgagatat     3660

accgtgtgaa gctattgtca gcttctctat ttcaaaatgc aatcagcata taactatatt     3720

gatattagaa gatatttgtt ttttaaaata tattgatgta tgataaagat gatctaattt     3780

gtgaatgcat atgtatgtgt ggttactttt tataatgtga aataatgaat aatgaattta     3840

ctcaaaataa aacataggtt aatgagat                                        3868


<210>  70
<211>  2788
<212>  DNA
<213>  Homo sapiens

<400>  70
tagcaaccga gcgagccttt ctcgcgtccc agcaacgcgc ccttccctct gccgggccta       60

ttctccctgg tgcccctccc ttcctcgagg ctgcagctca cccctcattg ggtctctcgt      120

tggtcaggag ggcgcgggtc tgcacactct cactcggtgc cggacatcag ttcctgcggc      180

tcttgctgtg ggagctgccc gagagccaga gcagtgggga gggacggcga gaaccaatgt      240

ttaagtttat ttaagaaaga agaaaaagag tcaagaagtt caagattttc gtcactctta      300

tttttaaggc acatccaaag ctccgtggag aaggggctgg agggtgggaa aattattttt      360

gtgcacattc catataagaa agaagagacc catcgaacat tcagtacgga gtcacctgga      420

aattggagat gttggatacg atcgcccgtg ccctgcagga cctgggcagg caggtgctgc      480

ccactctgcc ctcgctgagc caggaggaag tctctattat ctgggggaat gtatcagaat      540

ttgtgagacg gcagttaacc ctgcacaagg gggttcagat tccagcattt ggaactttca      600

ctttcataag acaaaagctt gaggtgggaa acaacaaatt tatcttaatc cagaggcctg      660

tgtttatcat ggtggagaag ctagtgcaga ttcatggact caaacaaaac aaagtatata      720

ctcctggtga aatcccaatt gttccactta attttgtcat gatatccctg gagggtccat      780

ttaacagaga tgtagtggaa ggatgtgtga aggagacgtt gcttttttta tcgcgttcca      840

tttccatgaa acaaaatgtg gagtttacat tcaaaggaat tggggtcctc atgatcagag      900

acagcaaagt gaagatgagg ttttataaag acttcctttg taccatggat ggaagtgggg      960

ctttggcaaa ggccctagca aataggcctg gcactgtgga ctcggtgttg tctagcagag     1020

aggccttgag gaagtggccc agcagtgtgc ttgcgtttcc aaggattgag ctcaaggaga     1080

tggaaaacaa actgcctatg gagacccttg tagaagaatg tggagagaat agagaaagga     1140

agtgcaagtt aaaagaccag tcagacaaag aagaaggcac cagagatatc tcatcaccca     1200

aaagacttcg agatagacaa gctttgttcc ctgccaaagt gacaaatgtc agcttgctgg     1260

aaaagtttga acgaagtgag agtggtggga agattatgac ccctgaaagc ttatcatatc     1320

caagttgtct gaaacacgac agtgagatga agccccaaac atctccagct tgccaggatc     1380

ataacaaggc aggacaggaa atgtgctatg tatgtttgca acgagcacaa cgaaattccc     1440

tgttgtacta cagtgaggaa aggaggagag agatagaaga tgagagactc atacagcagt     1500

atcagatgtt aaaggatcag gaggctctct tcagacacca gatgaaaagt ctggctacta     1560

gagaacagaa tcagaaaaat gctgcctata atcttggagt tgctgaagct ataagaaacc     1620

acaagaatga gaaaccggaa ttttataaat ccttcctatt tgacaaacgg ccactcagtc     1680

ctgcgcttaa tgctcttaag caagaggaat attcccggag tctcctgaaa caaatggata     1740

acagacagga aaacgaaata aagcaaagac aatacagaga gttgatggac cgcctggaac     1800

aagtgcaact cacagaggaa cttgctgcgc aaagagcgaa atttttaaaa gataagatgg     1860

aagaaacaca gtgttacaag agagctttgg atgcacagat aaagaacaaa ccctctcggc     1920

tgcccccctt tgagccagac tcctctgagc ccatctttgg taagaatgag ggtgaactga     1980

tggtggaaaa gcaaaagcga gaacaaaatt acatgaaaca ccagctggag gcagctgcta     2040

accacaagag gaaagccatc ctgcatcaac tagtggacca gaggcgggat ttgcaaatgc     2100

ttcagaggac acaaagagag cacttggcag acagaaccgc tgagctggag cgagtaaata     2160

gagtcaacca atgcttacag gaggactggg aaaggagtgc tgcgatgaag aagcagcgag     2220

acctggagga caaggctttt gaacgggctt cagacaagct gtttctccta gaccagtgtg     2280

agaagtatcg gcgctgcaag caatgccaga ggcgcacctc caacgtgggc gagagcaacc     2340

tgtggcccct gaacaagttc ctgcctggct cccggttgct tgtgtaaaac tcaaagtttg     2400

gctcttcgtt tcccggggaa agtttttatc ttttacatgt ttgggggtga ttgtgaaact     2460

gcgtattttt acctcagaga aaaaaatcat tgtttaggtt tggtgctttc attagattgc     2520

ttgttaagcc cttattgaat tcactcctgc tttcctccca cccccaatta tttcctatac     2580

tagtttctga tggcagtgaa ggtgtctgaa tggtcctgag ggctagaacc tgctgcacag     2640

gggctgggaa tgggatccag cttcattatg gctgctgggg tgctgctgac ccagccctgc     2700

tgctgctcca tgactttgtg tacaaaactt ttttcatctg taatgaatag tggcaataat     2760

aaatattttt taagcgcctg aaaaaaaa                                        2788


<210>  71
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  71
ggcagggacc cgcagctcag ctacagcaca gatcaggtga ggagcacacc aaggagtgat       60

ttttaaaact tactctgttt tctctttccc aacaagatta tcatttcctt taaaaaaaat      120

agttatcctg gggcatacag ccataccatt ctgaaggtgt cttatctcct ctgatctaga      180

gagcaccatg aagcttctca cgggcctggt tttctgctcc ttggtcctgg gtgtcagcag      240

ccgaagcttc ttttcgttcc ttggcgaggc ttttgatggg gctcgggaca tgtggagagc      300

ctactctgac atgagagaag ccaattacat cggctcagac aaatacttcc atgctcgggg      360

gaactatgat gctgccaaaa ggggacctgg gggtgcctgg gctgcagaag tgatcagcga      420

tgccagagag aatatccaga gattctttgg ccatggtgcg gaggactcgc tggctgatca      480

ggctgccaat gaatggggca ggagtggcaa agaccccaat cacttccgac ctgctggcct      540

gcctgagaaa tactgagctt cctcttcact ctgctctcag gagatctggc tgtgaggccc      600

tcagggcagg gatacaaagc ggggagaggg tacacaatgg gtatctaata aatacttaag      660

aggtggaatt tgtggaaa                                                    678


<210>  72
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  72
aggctcacta taaatagcag ccacctctcc ctggcagaca gggacccgca gctcagctac       60

agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctgag      120

tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat      180

gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca      240

tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt      300

gatcagcaat gccagagaga atatccagag actcacaggc cgtggtgcgg aggactcgct      360

ggccgatcag gctgccaata aatggggcag gagtggcaga gaccccaatc acttccgacc      420

tgctggcctg cctgagaaat actgagcttc ctcttcactc tgctctcagg agacctggct      480

atgaggccct cggggcaggg atacaaagtt agtgaggtct atgtccagag aagctgagat      540

atggcatata ataggcatct aataaatgct taagaggtgg aatttgttga aaca            594


<210>  73
<211>  2646
<212>  DNA
<213>  Homo sapiens

<400>  73
gacttctgca gtttctgttt ccttgactgg cagctcagcg gggccctccc gcttggatgt       60

tccgggaaag tgatgtgggt aggacaggcg gggcgagccg caggtgccag aacacagatt      120

gtataaaagg ctgggggctg gtggggagca ggggaaggga atgtgaccag gtctaggtct      180

ggagtttcag cttggacact gagccaagca gacaagcaaa gcaagccagg acacaccatc      240

ctgccccagg cccagcttct ctcctgcctt ccaacgccat ggggagcaat ctcagccccc      300

aactctgcct gatgcccttt atcttgggcc tcttgtctgg aggtgtgacc accactccat      360

ggtctttggc ccggccccag ggatcctgct ctctggaggg ggtagagatc aaaggcggct      420

ccttccgact tctccaagag ggccaggcac tggagtacgt gtgtccttct ggcttctacc      480

cgtaccctgt gcagacacgt acctgcagat ctacggggtc ctggagcacc ctgaagactc      540

aagaccaaaa gactgtcagg aaggcagagt gcagagcaat ccactgtcca agaccacacg      600

acttcgagaa cggggaatac tggccccggt ctccctacta caatgtgagt gatgagatct      660

ctttccactg ctatgacggt tacactctcc ggggctctgc caatcgcacc tgccaagtga      720

atggccgatg gagtgggcag acagcgatct gtgacaacgg agcggggtac tgctccaacc      780

cgggcatccc cattggcaca aggaaggtgg gcagccagta ccgccttgaa gacagcgtca      840

cctaccactg cagccggggg cttaccctgc gtggctccca gcggcgaacg tgtcaggaag      900

gtggctcttg gagcgggacg gagccttcct gccaagactc cttcatgtac gacacccctc      960

aagaggtggc cgaagctttc ctgtcttccc tgacagagac catagaagga gtcgatgctg     1020

aggatgggca cggcccaggg gaacaacaga agcggaagat cgtcctggac ccttcaggct     1080

ccatgaacat ctacctggtg ctagatggat cagacagcat tggggccagc aacttcacag     1140

gagccaaaaa gtgtctagtc aacttaattg agaaggtggc aagttatggt gtgaagccaa     1200

gatatggtct agtgacatat gccacatacc ccaaaatttg ggtcaaagtg tctgaagcag     1260

acagcagtaa tgcagactgg gtcacgaagc agctcaatga aatcaattat gaagaccaca     1320

agttgaagtc agggactaac accaagaagg ccctccaggc agtgtacagc atgatgagct     1380

ggccagatga cgtccctcct gaaggctgga accgcacccg ccatgtcatc atcctcatga     1440

ctgatggatt gcacaacatg ggcggggacc caattactgt cattgatgag atccgggact     1500

tgctatacat tggcaaggat cgcaaaaacc caagggagga ttatctggat gtctatgtgt     1560

ttggggtcgg gcctttggtg aaccaagtga acatcaatgc tttggcttcc aagaaagaca     1620

atgagcaaca tgtgttcaaa gtcaaggata tggaaaacct ggaagatgtt ttctaccaaa     1680

tgatcgatga aagccagtct ctgagtctct gtggcatggt ttgggaacac aggaagggta     1740

ccgattacca caagcaacca tggcaggcca agatctcagt cattcgccct tcaaagggac     1800

acgagagctg tatgggggct gtggtgtctg agtactttgt gctgacagca gcacattgtt     1860

tcactgtgga tgacaaggaa cactcaatca aggtcagcgt aggaggggag aagcgggacc     1920

tggagataga agtagtccta tttcacccca actacaacat taatgggaaa aaagaagcag     1980

gaattcctga attttatgac tatgacgttg ccctgatcaa gctcaagaat aagctgaaat     2040

atggccagac tatcaggccc atttgtctcc cctgcaccga gggaacaact cgagctttga     2100

ggcttcctcc aactaccact tgccagcaac aaaaggaaga gctgctccct gcacaggata     2160

tcaaagctct gtttgtgtct gaggaggaga aaaagctgac tcggaaggag gtctacatca     2220

agaatgggga taagaaaggc agctgtgaga gagatgctca atatgcccca ggctatgaca     2280

aagtcaagga catctcagag gtggtcaccc ctcggttcct ttgtactgga ggagtgagtc     2340

cctatgctga ccccaatact tgcagaggtg attctggcgg ccccttgata gttcacaaga     2400

gaagtcgttt cattcaagtt ggtgtaatca gctggggagt agtggatgtc tgcaaaaacc     2460

agaagcggca aaagcaggta cctgctcacg cccgagactt tcacatcaac ctctttcaag     2520

tgctgccctg gctgaaggag aaactccaag atgaggattt gggttttcta taaggggttt     2580

cctgctggac aggggcgtgg gattgaatta aaacagctgc gacaacaaaa aaaaaaaaaa     2640

aaaaaa                                                                2646


<210>  74
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  74
ggatttaaaa ccgttctccc attaatgcca aagccagcag aggtaccaac tatagctcca       60

cggccagaag ataccagcag ctctgccttt actgaaattt catctggaga aaggtccaca      120

gcacaatgag gcttttcaca ggcattgttt tctgctcctt ggtcatggga gtcaccagtg      180

aaagctggcg ttcgtttttc aaggaggctc tccaaggggt tggggacatg ggcagagcct      240

attgggacat aatgatatcc aatcaccaaa attcaaacag atatctctat gctcggggaa      300

actatgatgc tgcccaaaga ggacctgggg gtgtctgggc tgctaaactc atcagccgtt      360

ccagggtcta tcttcaggga ttaatagact gctatttatt tggaaacagc agcactgtat      420

tggaggactc gaagtccaac gagaaagctg aggaatgggg ccggagtggc aaagaccccg      480

accgcttcag acctgacggc ctgcctaaga aatactgagc ttcctgctcc tctgctctca      540

gggaaactgg gctgtgagcc acacacttct ccccccagac agggacacag ggtcactgag      600

ctttgtgtcc ccaggaactg gtatagggca cctagaggtg ttcaataaat gtttgtcaaa      660

ttgaaaaaaa aaaaa                                                       675


<210>  75
<211>  9733
<212>  DNA
<213>  Homo sapiens

<400>  75
gccccgggag cgtgccctcg gggcggagag cgtcgcggcc cgcgccgagg cgatgctcgg       60

gtggctgcga gctgccggcg gcgagaggcc atagacgggc atgggccttg cgtcccacca      120

cccctaggga ccctcgagcc tcgcccctct gctccgactc gccggaccga cgcgatggcc      180

tcagaagtgg tgtgcgggct catcttcagg ctgctgctgc ccatctgcct ggcagtagca      240

tgtgcattcc gatacaatgg gctctccttt gtctacctta tctacctctt gctcattcct      300

ctgttctcag aaccaacaaa aacgacgatg caaggacata cgggacggtt attaaagtct      360

ctgtgcttca tcagtctttc cttcctgttg ctgcacatca ttttccacat cacgttggtg      420

agccttgaag ctcaacatcg tattgcacct ggctacaact gctcaacatg ggaaaagaca      480

ttccggcaga tcggctttga aagcttaaag ggagctgatg ctggcaatgg gatcagagtg      540

tttgtacctg acatcgggat gttcattgct agtctgacca tctggctcct ctgtagaaac      600

attgttcaga aacctgtgac agacgaagca gcacagagta acccggagtt tgaaaatgaa      660

gaattggctg aaggagaaaa aattgattca gaagaggcac tgatctatga agaggatttc      720

aatggaggag atggtgttga aggcgagttg gaagaaagca cgaagttaaa aatgttccgc      780

aggcttgcct ctgtggcctc taagctcaag gagttcattg gcaacatgat caccactgct      840

gggaaagtcg ttgttaccat cttactgggc tcctcgggca tgatgttgcc gtctttgaca      900

tcatctgtgt atttttttgt atttttgggt ctgtgcacct ggtggtcctg gtgccggacg      960

ttcgacccat tgctgttcag ctgtctctgt gttctgctgg ctattttcac tgctggacat     1020

ttgattggac tttatttata ccagttccaa ttctttcaag aggcagttcc acccaatgac     1080

tactatgcaa ggttgtttgg tatcaagtca gtaattcaaa cggactgttc aagtacttgg     1140

aagatcatag tgaacccgga cctgtcgtgg taccaccacg ccaaccctat cctcctgctg     1200

gtgatgtact acactctggc cactctgatc cgcatctggc tgcaagagcc ccttgtgcag     1260

gatgagggga ccaaagaaga ggacaaagcc ctggcttgta gccccatcca aataacagcg     1320

gggaggaggc ggagcctgtg gtacgcaacc cattacccca ctgatgagag aaaactttta     1380

tccatgaccc aggatgacta caaaccatct gatggcctgc tggtgactgt gaacggcaac     1440

cccgtggatt accacaccat ccacccaagc ctgcccatgg agaacggccc tggcaaagcc     1500

gacctctact ccacccctca gtaccggtgg gagccctctg atgaatcctc agaaaagcga     1560

gaggaggaag aggaagagaa agaagaattt gaagaagaaa ggagccgtga ggaaaaaaga     1620

agtatcaaag ttcatgccat ggtctccgta ttccaattta ttatgaaaca aagttacatc     1680

tgtgccctca tagctatgat ggcctggagc atcacctatc acagctggct gaccttcgtg     1740

ctgctgatct ggtcgtgcac tctttggatg attcgcaaca gaagaaaata tgccatgatc     1800

agctctccct tcatggtggt ttatggaaac ctattgttga tattacagta tatatggagt     1860

tttgaacttc ctgaaattaa aaaagttcca ggatttttag aaaagaaaga gccaggagaa     1920

cttgcttcca aaatcctttt caccattact ttttggctac tgctgaggca gcacctcaca     1980

gagcaaaaag ctctgcaaga aaaggaagct cttttatcgg aagtcaaaat tggcagtcag     2040

gaaaatgaag aaaaagatga ggaacttcaa gatatacaag tggaaggaga gcccaaagag     2100

gaggaagaag aggaagcgaa ggaagagaag caagagagaa agaaggtaga gcaagaggaa     2160

gctgaagaag aagatgagca ggacatcatg aaagtcctgg gcaatctggt ggtggccatg     2220

ttcatcaagt actggatcta cgtctgcgga ggcatgttct tcttcgtcag cttcgagggt     2280

aaaatcgtaa tgtacaaaat catctacatg gtgctgttcc tgttctgtgt ggccctatac     2340

caggtgcact atgaatggtg gaggaaaatt ctaaaatatt tttggatgtc agtggttatt     2400

tacactatgc tggtgcttat ctttatatac acatatcagt ttgagaactt cccaggcctg     2460

tggcaaaata tgactggact gaaaaaagaa aagcttgagg atcttggctt aaagcagttt     2520

actgtggctg aactattcac tcgcatattc atcccaacct cctttctgct ggtgtgcatt     2580

ttacacctgc actacttcca tgaccggttc cttgaactca cagacctcaa gtccattccc     2640

agcaaagaag acaacaccat ctacagactg gcccacccgg aaggaagcct cccggacctc     2700

accatgatgc atctgactgc cagcctggag aagccggagg tgaggaagtt ggctgagcct     2760

ggggaggaga agcttgaggg ctactctgaa aaagcccaga agggtgatct tgggaaagac     2820

agcgaggagt cagaggagga cggagaggaa gaggaggaat ccgaggagga ggaagaaaca     2880

tcagacttaa ggaacaaatg gcacctggtg attgaccgcc tcactgtgct cttcttaaaa     2940

ttcctggagt attttcacaa gctgcaggtg ttcatgtggt ggattttgga gttgcacatc     3000

atcaaaatcg tttcctctta cattatctgg gtttctgtga aagaggtgtc tctgttcaac     3060

tatgtatttt tgatttcttg ggcttttgct ctgccgtacg ccaagctgcg ccgtctggct     3120

tcaagtgtct gcacagtctg gacgtgtgtg atcatcgtct gcaaaatgtt gtaccagctc     3180

caaaccatta agcctgagaa cttctctgtt aactgttcct tgccaaatga aaatcaaaca     3240

aacatcccct ttaatgagtt gaacaagtct ctgctctaca gcgctcctat cgatcctaca     3300

gagtgggtcg gcctgcggaa gtcttcgcct ctgctagtct acctgaggaa taacctcctg     3360

atgctggcta tcctggcctt tgaagtcacc atttaccgcc atcaggaata ctatcgaggt     3420

cgaaataacc tgacggcccc tgtgtctaga actatctttc atgacattac aagactacat     3480

ctagatgatg gacttattaa ttgtgccaaa tatttcatta attacttctt ttacaagttt     3540

ggtctggaga cctgtttcct aatgtcagtt aacgtcattg gccagcgaat ggatttctat     3600

gccatgatcc acgcctgctg gctgatcgct gtcttatata gacgcagaag gaaagccatc     3660

gcagagatct ggcccaagta ctgctgcttc ctggcatgca tcatcacctt ccagtatttc     3720

atctgcattg gcatcccacc tgctccttgc cgagattacc cgtggagatt caagggtgcc     3780

agcttcaatg acaacatcat aaagtggctg tacttcccag atttcattgt gcggcccaac     3840

cctgtgtttc tcgtctatga cttcatgctg cttctgtgtg cctccttaca acggcagatt     3900

tttgaggatg agaacaaggc tgcagtgcga atcatggcag gtgacaatgt cgagatctgc     3960

atgaaccttg atgcggcctc cttcagccaa cataaccctg tgccagattt tattcactgc     4020

agatcttact tagacatgtc caaagtgatc atcttcagct acctcttctg gtttgtgctc     4080

accatcatct tcatcactgg gaccaccagg atcagcatct tttgcatggg gtacctggtg     4140

gcctgtttct acttcctgct ctttgggggc gatttgctgt tgaaacccat caagagcatc     4200

ctgcgctact gggactggct gatcgcatac aacgtttttg tgattacgat gaaaaatatc     4260

ctgtcaatag gagcatgtgg atacattgga acattggtgc acaatagttg ttggttgatc     4320

caggctttca gcctggcctg cacagtcaaa ggctatcaaa tgcctgctgc taattcaccc     4380

tgtacacttc ccagtgggga agcaggaatc atttgggaca gcatatgttt tgccttcctc     4440

ctgctgcaaa gaagagtttt catgagttat tattttctac atgttgtggc tgatataaaa     4500

gcttcccaga ttctggcatc aagaggagct gaacttttcc aggccacaat tgtaaaagct     4560

gtaaaggcaa gaattgagga agagaagaag tccatggacc agctgaagcg acagatggat     4620

cgcatcaagg ccaggcaaca gaaatataaa aagggtaagg agaggatgct gagcttgacc     4680

caggagccag gggaaggcca ggacatgcaa aaactctctg aagaggatga tgaaagagaa     4740

gcagacaaac agaaagccaa gggcaaaaaa aagcagtggt ggcggccttg ggttgatcat     4800

gcttccatgg tcaggagtgg agattattat ttgtttgaaa cggatagtga agaggaggaa     4860

gaggaagaat taaagaagga agatgaagaa cctccacgaa ggtcagcatt ccagtttgtt     4920

tatcaagcct ggattactga tcctaaaaca gcactccgac aaagacacaa agagaaaaaa     4980

aggtctgcaa gagaagaacg gaaacgaagg cggaaaggat ccaaggaggg tcctgtggaa     5040

tgggaagacc gggaggatga accaatcaaa aagaaatccg atggaccaga taatatcatc     5100

aagaggatat ttaatatttt gaaatttacc tgggtcctat ttctggcaac agtggacagt     5160

ttcactactt ggcttaactc catttcaagg gagcatattg atatatctac agttctgaga     5220

attgaacgat gcatgctgac cagagaaatt aagaagggca atgttccaac tcgggagagc     5280

atccacatgt actatcagaa ccacatcatg aacctttcca gagagtcggg actggacacc     5340

attgacgagc atcccggagc tgcttcaggt gcacagacag cccacaggat ggatagttta     5400

gattcacatg acagtatctc cagcgagccc acgcagtgta ccatgctgta ctcacgccag     5460

gggaccactg agaccatcga ggaggtggag gctgagcagg aggaggaggc agggagcacg     5520

gcgcctgagc ccagggaggc caaggagtac gaggccactg ggtacgatgt gggagccatg     5580

ggtgccgagg aggccagcct caccccagag gaagagctga cacagttctc caccttggac     5640

ggggatgtgg aggccccacc ctcctacagc aaggctgtga gcttcgagca tctgtccttc     5700

ggctcgcagg acgactctgc aggcaagaac cgtatggcag tcagcccgga cgacagccgc     5760

accgacaagc tggggtccag catcttacct cccctgaccc atgagctgac ggccagcgag     5820

ctgctgctga aaaagatgtt tcacgacgat gagcttgaag agtcagagaa attctacgtg     5880

gggcagcccc gatttctgct gctcttctat gccatgtaca ataccctggt ggcccgctcg     5940

gagatggtgt gctacttcgt gatcatcctc aaccacatgg tctctgcctc catgatcacg     6000

ctcctgcttc ccatcctcat cttcctctgg gccatgttgt ccgtccccag gcccagccgc     6060

cggttctgga tgatggccat cgtctatact gaggtggcaa ttgtagtcaa gtatttcttc     6120

caatttgggt tctttccctg gaataagaat gtggaggtga acaaagataa accgtatcac     6180

cccccaaaca tcataggagt ggaaaagaag gaaggttatg ttctctatga cctcatccag     6240

ctcctggctc tgttctttca tcgatcaatt ttgaagtgcc atggcttatg ggatgaagat     6300

gacatgactg aaagtggcat ggccagggag gaatcagatg atgagctctc cctcggtcat     6360

ggcaggaggg actcctccga ttctctcaag tccatcaacc tggccgcgtc tgtggagtca     6420

gtgcatgtga ccttcccgga gcagcagaca gctgtccgga ggaagcgctc cggcagcagc     6480

tccgagccat cccagagatc cagcttttct tcaaacagat cccaaagagg cagcacaagc     6540

acccgaaaca gcagtcaaaa aggaagcagt gttttgagta ttaagcaaaa aggcaaaagg     6600

gaactttata tggaaaagct tcaagaacat ttaatcaaag caaaagcctt taccataaag     6660

aagacgctgg agatctatgt gcccatcaaa cagttctttt acaacctcat ccacccggag     6720

tatagcgccg tgactgacgt gtatgtactc atgttcctgg ctgacactgt ggacttcatc     6780

atcattgtct tcggcttttg ggcctttggg aaacactcag cagctgcaga catcacctct     6840

tcactgtcag aggaccaggt cccggggccg tttttggtga tggtcctcat tcagtttgga     6900

accatggtgg tggaccgagc cctctacctc aggaagactg tactgggaaa ggtcatcttc     6960

caggtcattc ttgtgttcgg aattcacttc tggatgttct tcatcttacc tggtgtgact     7020

gagaggaaat tcagccagaa cctggttgcc cagctttggt actttgtgaa atgtgtttac     7080

ttcgggttgt ctgcttacca gatccgttgt ggctacccaa cgcgagtcct ggggaacttc     7140

ctcaccaaga gctacaatta cgtcaacctc ttcttattcc aagggtttcg cctcgtgccc     7200

tttttgactg agctgagggc agtgatggac tgggtgtgga cggacacaac tttgagcctg     7260

tccagctgga tctgtgtgga ggacatctat gctcacatat tcatcctgaa gtgttggcgg     7320

gagtcggaga agagataccc tcagccacgg ggccagaaga agaagaaagt ggtgaagtat     7380

ggcatgggag gaatgatcat cgtcctgctc atctgcattg tctggtttcc tcttctcttc     7440

atgtctttga tcaaatctgt ggctggggtc atcaaccagc ccctggacgt ctccgtcaca     7500

attaccctgg gagggtatca gcctattttc acaatgagtg cccaacaaag ccagttgaaa     7560

gttatggacc agcagagctt taacaaattt atacaagctt tttctaggga caccggtgct     7620

atgcaatttc tggaaaatta tgaaaaagaa gacataacag tagcagaact ggaaggaaac     7680

tcaaattctt tgtggaccat cagcccaccc agtaagcaga aaatgataca cgaactcctg     7740

gaccccaata gtagcttctc tgttgttttt tcatggagta ttcagagaaa cttaagtctg     7800

ggtgcaaaat cggaaatagc aacagataag ctttcttttc ctcttaaaaa tattactcga     7860

aagaatatcg ctaaaatgat agcaggcaac agcacagaaa gttcaaaaac accagtgacc     7920

atagaaaaga tttatccata ttatgtgaaa gcacctagtg attctaactc aaaacctata     7980

aagcaacttt tatctgaaaa taatttcatg gatattacca tcattttgtc cagagacaat     8040

acaactaaat ataacagtga gtggtgggtt ctcaacctga ctggaaacag aatatacaat     8100

ccgaactctc aggccctgga actggtggtc ttcaatgaca aagtcagtcc cccaagtctg     8160

gggttcctgg ctggctatgg tattatggga ttatatgctt cagttgtcct tgtgattggg     8220

aaatttgtcc gtgaattctt cagtgggatt tctcactcca tcatgtttga agagcttcca     8280

aatgtggatc gaattttgaa gttgtgcaca gatatttttt tagttcgaga gacaggagaa     8340

ctggagctag aagaagatct ctatgccaaa ttaatattcc tatatcgctc accagagaca     8400

atgatcaaat ggactagaga aaaaacaaat tgaaacctta gaacacagac tgcaaataat     8460

gttaacattt gaattttttt taaaagcaca atattctcat aagagctaag catttctagt     8520

tcgacggaaa tggtttgttt ctcttctgat aggtagacaa aaggagctga tatccttctg     8580

cagtaaaagc taccttgcaa gttaaggcac tgttgaaaat gttatttgta actccatttc     8640

tctgaaatca gggctacttg ctttatgttt tagtcaacag tgtctcgcat tctgattgat     8700

catgtgaagg aatcatttat gggccccgtc cctaagagaa acagaagagg agtcagaaag     8760

aaagatgcct gtgttttcct ctgtggggcc cgtgcacttc ctggagagat gctacaatgc     8820

aatatacagc gctccatccc cactggggaa gctgctgtga tgagactaga tgagccttca     8880

acacactcag aaaatgcaac agcaataggg ggcagacagc tcctacctgt gtttctagga     8940

gcaaaagaga gggaactaat tgcccgtgaa gacgccagtg gaaggatcag cctcattcta     9000

agcaaaaaca tagtattagt gatactctta ctgccttatc ttaaccaagg actaatagga     9060

tacctttcca ttaaacacca gtgacttctc aggaaaaaaa aaaaaaagga gcaaaacaaa     9120

tgatgtgtac acctgctttg ttatggtcca ccagtgacca gcttcaatga ggggaaccat     9180

tctggagggc tgcggtctcc tgtgcaaaca gacatgaggc agaagagtaa aaagaccaac     9240

ccagtgggac ctagaatact ttgtaactct ttaataactg aggtcaggac cgctcttctg     9300

ccttcccctt cccttaacgt gctttttccc atttccatga tttaaggcaa tggtttttcc     9360

agtatgtgac attttccttc ctgtttttca ggtatatcaa agagtttaca tattccaatt     9420

cacattttta catctgagac gggtttttta agttcataat tatgaaagaa atatgtatat     9480

tgagcttggg gaaataaaaa tggccttttc ttaaattatt attattggta atacaacctc     9540

ttcattaaat aacaatgtag catgaaaaat ttatgattga aatgtagttt tcattccata     9600

ttaagataca gtttctgaga agaatcattg aatggactag aatatgtcaa aaattgatcc     9660

tgtgtagttt gggttcaggg ctgacttaaa ataaagcaca tcctgcaaag tcaaaaaaaa     9720

aaaaaaaaaa aaa                                                        9733


<210>  76
<211>  7639
<212>  DNA
<213>  Homo sapiens

<400>  76
agccagccag gaggacgggc ccgcccgcgc gctactcgga gcccagcctc gttgcggcca       60

tcgccctgcc ggaccgcgcc tcaggctccc ccagccggaa gaattaacct cgagtctgca      120

cgcttttaag aacaaggcct ttaaaaaatc caaagtgtgt ggagtttgca aacaaattat      180

tgacggtcaa ggtatttcat gccgagcctg caagtattcc tgccacaaga aatgtgaagc      240

caaggtggtg attccctgcg gtgtgcaagt ccgactggaa caggctccag ggagttccac      300

gctgtccagt tctctctgcc gtgataaacc tctgcggccc gtcatcctga gtcccaccat      360

ggaggagggc catgggctgg acctcactta catcacggag cgcatcatcg ctgtgtcctt      420

ccctgccggc tgctctgagg agtcctacct gcacaaccta caggaggtca cgcgcatgct      480

caagtccaag cacggggaca actacctggt attaaacctt tcagaaaaga gatatgacct      540

tacgaagctt aacccaaaga tcatggatgt gggctggcca gagctccacg caccgcccct      600

ggataagatg tgtaccatat gcaaggcgca ggagtcctgg ctgaacagca acctccagca      660

tgtggtcgtc attcactgca ggggcgggaa aggacgcata ggagtggtca tatcatccta      720

catgcatttc accaacgtct cagccagcgc cgaccaggcc cttgacaggt ttgcaatgaa      780

gaagttttat gatgacaaag tttcagcttt aatgcagcct tcccaaaaac ggtatgttca      840

gttcctcagt gggctcctgt ccggatcggt gaaaatgaat gcctctcccc tgttcctgca      900

ttttgtcatc ctccacggca cccccaactt cgacacaggt ggagtgtgcc ggccctttct      960

gaagctctac caagccatgc agcctgtgta cacctccggg atctacaacg ttggcccaga     1020

aaaccccagc aggatctgca tcgtcatcga gccggcccag cttctgaagg gagatgtcat     1080

ggtgaaatgc taccacaaga aataccgctc ggccacccgt gacgtcattt tccgcctgca     1140

gtttcacact ggggctgtgc agggctacgg gctggtgttt gggaaggagg atctggacaa     1200

tgccagcaaa gatgaccgtt ttcctgacta tgggaaggtt gaattagtct tctctgccac     1260

gcctgagaag attcaagggt ccgaacactt gtacaacgac cacggtgtga ttgtggacta     1320

caacacaaca gacccactga tacgctggga ctcgtacgag aacctcagtg cagatggaga     1380

agtgctacac acgcagggcc ctgtcgatgg cagcctttac gcgaaggtga ggaagaaaag     1440

ctcctcggat cctggcatcc caggtggccc ccaggcaatc ccggccacca acagcccaga     1500

ccacagtgac cacaccttgt ctgtcagcag tgactccggc cactctacag cctctgccag     1560

gacggataag acggaagagc gcctggcccc aggaaccagg aggggcctga gtgcccagga     1620

gaaggcagag ttggaccagc tgctcagtgg ctttggcctg gaagatcctg gaagctccct     1680

caaggaaatg actgatgctc gaagcaagta cagtgggacc cgccacgtgg tgccagccca     1740

ggttcacgtg aatggagacg ctgctctgaa ggatcgggag acagacattc tggatgacga     1800

gatgccccac cacgacctgc acagtgtgga cagccttggg accctgtcct cctcggaagg     1860

gcctcagtcg gcccacctgg gtcccttcac ctgccacaag agcagccaga actcactcct     1920

atctgacggt tttggcagca acgttggtga agatccgcag ggcaccctcg ttccggacct     1980

gggccttggc atggacggcc cctatgagcg ggagcggact tttgggagtc gagagcccaa     2040

gcagccccag cccctgctga gaaagccctc agtgtccgcc cagatgcagg cctatgggca     2100

gagcagctac tccacacaga cctgggtgcg ccagcagcag atggttgtag ctcaccagta     2160

tagcttcgcc ccagatgggg aggcccggct ggtgagccgc tgccctgcag acaatcctgg     2220

cctcgtccag gcccagccca gagtgccact cacccccacc cgagggacca gcagtagggt     2280

ggctgtccag aggggtgtag gcagtgggcc acatccccct gacacacagc agccctctcc     2340

cagcaaagcg ttcaaaccca ggtttccagg agaccaggtt gtgaatggag ccggcccaga     2400

gctgagcaca ggcccctccc caggctcgcc caccctggac atcgaccagt ccatcgagca     2460

gctcaacagg ctgatcctgg agctggatcc caccttcgag cccatcccta cccacatgaa     2520

cgccctcggt agccaggcca atggctctgt gtctccagac agcgtgggag gtgggctccg     2580

ggcaagcagc aggctgcctg acacaggaga gggccccagc agggccaccg ggcggcaagg     2640

ctcctctgct gaacagcccc tgggcgggag actcaggaag ctgagcctgg ggcagtacga     2700

caacgatgct ggggggcagc tgcccttctc caaatgtgca tggggaaagg ctggtgtgga     2760

ctatgcccca aacctgccgc cattcccctc accagcggac gtcaaagaga cgatgacccc     2820

tggctatccc caggacctcg atattatcga tggcagaatt ttaagtagca aggagtccat     2880

gtgttcaact ccagcatttc ctgtgtctcc agagacaccg tatgtgaaaa cagcgctgcg     2940

ccatcctccg ttcagcccac ctgagccccc gctgagcagc ccagccagtc agcacaaagg     3000

aggacgtgaa ccacgaagct gccctgagac gctcactcac gctgtgggga tgtcagagag     3060

ccccatcgga cccaaatcca cgatgctccg ggctgatgcg tcctcgacgc cctcctttca     3120

gcaggctttt gcttcttcct gcaccatttc cagcaacggc cctgggcaga ggagagagag     3180

ctcctcttct gcagaacgcc agtgggtgga gagcagcccc aagcccatgg tttccctgct     3240

ggggagcggc cggcccaccg gaagtcccct cagcgctgag ttctccggta ccaggaagga     3300

ctccccagtg ctgtcctgct tcccgccgtc agagctccag gctcctttcc acagccatga     3360

gctgtcccta gcagagccac cggactccct ggcgcctccc agcagccagg ccttcctggg     3420

cttcggcacc gccccagtgg gaagtggcct tccgcccgag gaggacctgg gggccttgct     3480

ggccaattct catggagcgt caccgacccc cagcatcccg ctgacagcga caggggctgc     3540

cgacaatggc ttcctgtccc acaactttct cacggtggcg cctggacaca gcagccacca     3600

cagtccaggc ctgcagggcc agggtgtgac cctgcccggg cagccacccc tccctgagaa     3660

gaagcgggcc tcggaggggg atcgttcttt gggctcagtc tctccctcct ccagtggctt     3720

ctccagcccg cacagcggga gcaccatcag tatccccttc ccaaatgtcc ttcccgactt     3780

ttccaaggct tcagaagcgg cctcacctct gccagatagt ccaggtgata aacttgtgat     3840

cgtgaaattt gttcaagaca cttccaagtt ctggtacaag gcggatattt caagagaaca     3900

agccatcgcc atgttgaagg acaaggagcc gggctcattc attgttcgag acagccattc     3960

cttccgaggg gcctatggcc tggccatgaa ggtggccacg cccccacctt cagtcctgca     4020

gctgaacaag aaagctggag atttggccaa tgaactcgtc cggcactttt tgatcgagtg     4080

taccccgaag ggagtgcggt tgaaagggtg ctcgaatgaa ccatatttcg ggagcctgac     4140

ggccttggtg tgccagcatt ccatcacgcc cttggccttg ccgtgcaagc tgcttatccc     4200

agagagagat ccattggagg aaatagcaga aagttctccc cagacggcag ccaattcagc     4260

agctgagctg ttgaagcagg gggcagcctg caatgtgtgg tacttgaact ctgtggagat     4320

ggagtccctc accggccacc aggcgatcca gaaggccctg agcatcaccc tggtccagga     4380

gcctccacct gtgtccacag ttgtgcactt caaggtgtca gcccagggca tcaccctgac     4440

agacaatcag aggaagctct tcttccggag gcattacccc gtgaacagtg tgattttctg     4500

tgccttggac ccacaagaca ggaagtggat caaagatggc ccttcctcaa aagtctttgg     4560

atttgtggcc cggaagcagg gcagtgccac ggataatgtg tgccacctgt ttgcagagca     4620

tgaccctgag cagcctgcca gtgccattgt caacttcgta tcaaaggtca tgattggttc     4680

cccaaagaag gtctgagaac tcccctccct ccctggaccc accgatgcct ctcgaagccc     4740

tggagacagc cgttgggtga gggtggggcc cccacttttt accaaactag taaacctgac     4800

attccaggcc catgagggga aagaggatct tccagctctg caaaaacaag aacaaacaac     4860

atcaccgtga attggccttt cctgaaagtg acttatctga cacatctctg tagccacatg     4920

ctttttgggt agaagaagct gggcatgggt gcaccccacc ccctagggtc cccatgggaa     4980

agggacatgc aaggaaacag cacagaacac gaggtggtcc ccatgtccct ggcacactag     5040

cattccgggg gatgaggaat ccccagccct tgaggcagag gtgccgagtg actgccatgc     5100

ttcgcccgtc cgcatgggcg cttctgtcca gctgcacccg aggccggggg tttccctcac     5160

ctcggtcttc ccaagatgga gatgctaacg aaactgagaa gggggcgtat gtttgacgaa     5220

ggtttgtgca agtcaggccc ttctggaaca cagcagggcc tacaacgagg ggcctttgcg     5280

atgggctgtg aggatggggg tggtgggaag aattggccac gttggagacc ccatgccacc     5340

ccaccatggt gagtgctctg tgcctcctgc tcacctgtgg tgagctgggc gagctgggcg     5400

agctgggcga gctgggctgg ggagagcctg tgaggaccga gaggagaaat gagaagaagg     5460

aacaaaaata ttatttctat gtaatttata ttttacttat gccaaattat ttatgataat     5520

ttgccattgc tatactgtac cagtgtcaaa tgctgcagcc tgccaagctg tgattttgtg     5580

aggcttgtcc ctatgtagga tgcaccgcag gcccctggcc actgaaagag tgtgcagtgg     5640

actgtgggtc tcccatatgc ggtgccgccc aaaggtggct ttgcctcaag caacctaccc     5700

tgatgtttta ctcattggaa tgtttttccc cgattgtgga tgacttcttt tctgatggag     5760

agagtccagg agggatggaa aactcctgga tttaagctca gcatccccca catgggcttt     5820

tcgatcatct tcaggcctga agctgcacga cctgaagttc gcctgcattt atcagccctc     5880

tttgtgctgc tccttgccac cttggggttc ctgctgggga ccatgtgtgg ttgtggcatg     5940

tgtgagcaga agggaggatg aggaaaaaga gaagaaaccc cggtactgac aagctgtttt     6000

tgagtgccac tgtttgccat catctaagcc actgaatcaa gtgtatttca ggcttatttc     6060

aacattccaa tgccctggtt ttcctgcttg aatctgttcg tggtcaaagg tttgggggaa     6120

tttgtgaccc tggaacatcc ccagagtgaa agatggagct gggccacatc agaataaggc     6180

cttggcccca tcctctcaca gcctaggtgc tctgcaggca tgctgactgt cctgattgcg     6240

atccagcccg aaattccctc ctctgctttc aaaagtcaaa tcccccattc ttaggccaca     6300

ctggtgtcac aagctcctgt cagggagctg gggtttggga atgtgctttg tgaactctgc     6360

tttaaagtga ggggccgagg aaaacttaga aacaggcaga gttggaagca gccaaatcac     6420

agtgggtgtt gtgtgtgtgt gcgtgtgtgc atgcgtgcgt gtatgcgtgt gtgaaagcag     6480

gtggaccatt ccacttttta gctcctattg atgcaccaaa ccaagtgcct catttctgtg     6540

ccaaatgttt gccttggtcg ttgtggacct ccttctctaa cttgcggtgg catgactgtc     6600

aggaggtgct ggcattttca gcagatcctc atgtgttgac cctgatgtct ttagcagagg     6660

cctctagcat ctcggttttt catccactgc aggaatgtgg ccacagggag cagaggtttg     6720

tactttcccc aagaggtcct catcctgaga cggtctctac ccatgtttaa cccaaagagt     6780

gcaggccagg ttccttatcc ttctgatgaa ggatgagaga gctcatttag aagtcagagc     6840

aaactagggt ctcagtattg agaaacgcag cctgccaggg aatcacagag acatcggggt     6900

gcccgcgatg gccctcatga agccatgcct cgacggcatt caggaagccc tgcaaacgtg     6960

ctttttgaac tcattggcca ggtgtgattt ttacacaagg taaacgtggt caagggcatc     7020

ggggaatttg ctccaagcag atagctccct ctgaggaacc aaaggaagca agtttccacg     7080

atttctgaag agctggtata ggaagtttct ttcttccttt tgtgttacat gtgcattaaa     7140

cagaacaagc tgtgtgtcat cacagattgt actgtgggct cagaaaccgt gagagagccc     7200

ccaccgtgga caccggctct agggccacag gaaaaggaac gtttccaggc attttgtctc     7260

cagggctccc gctggacagg cacgtactgc cctggggagt aaatgcggag agttcacgaa     7320

ctgtgcccaa cgcatgttat agccagggtc ctactaacta ctcagtaaaa gaacgtattg     7380

ttgtattcct ccagtgttaa gctatagcca tgttaaaagt cactgtgcat ttattctcag     7440

catcaaatac cttgtaacgt cttctctgcc ttgttagtgc atatttttac ttttctgata     7500

ctgtaaagaa tatatccagt atgtaaatga atgttctata aatcttttgt atagtcattt     7560

tctctgctcc ttaaatatca tctctattca gagtataata aaattatgaa cttggtaaaa     7620

aaaaaaaaaa aaaaaaaaa                                                  7639


<210>  77
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  77
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  78
<211>  1577
<212>  DNA
<213>  Homo sapiens

<400>  78
ggctgaggca acctgaagga ggagctctca ttaccttctg cccatcactt aataaatagc       60

cagccaattc atcaacattc tggtacactg ttggagagat gagacagtca caccagctgc      120

ccctagtggg gctcttactg ttttctttta ttccaagcca actatgcgag atttgtgagg      180

taagtgaaga aaactacatc cgcctaaaac ctctgttgaa tacaatgatc cagtcaaact      240

ataacagggg aaccagcgct gtcaatgttg tgttgtccct caaacttgtt ggaatccaga      300

tccaaaccct gatgcaaaag atgatccaac aaatcaaata caatgtgaaa agcagattgt      360

cagatgtaag ctcgggagag cttgccttga ttatactggc tttgggagta tgtcgtaacg      420

ctgaggaaaa cttaatatat gattaccacc tgatcgacaa gctagaaaat aaattccaag      480

cagaaattga aaatatggaa gcacacaatg gcactcccct gactaactac taccagctca      540

gcctggacgt tttggccttg tgtctgttca atgggaacta ctcaaccgcc gaagttgtca      600

accacttcac tcctgaaaat aaaaactatt attttggtag ccagttctca gtagatactg      660

gtgcaatggc tgtcctggct ctgacctgtg tgaagaagag tctaataaat gggcagatca      720

aagcagatga aggcagttta aagaacatca gtatttatac aaagtcactg gtagaaaaga      780

ttctgtctga gaaaaaagaa aatggtctca ttggaaacac atttagcaca ggagaagcca      840

tgcaggccct ctttgtatca tcagactatt ataatgaaaa tgactggaat tgccaacaaa      900

ctctgaatac agtgctcacg gaaatttctc aaggagcatt cagcaatcca aacgctgcag      960

cccaggtctt acctgccctg atgggaaaga ccttcttgga tattaacaaa gactcttctt     1020

gcgtctctgc ttcaggtaac ttcaacatct ccgctgatga gcctataact gtgacacctc     1080

ctgactcaca atcatatatc tccgtcaatt actctgtgag aatcaatgaa acatatttca     1140

ccaatgtcac tgtgctaaat ggttctgtct tcctcagtgt gatggagaaa gcccagaaaa     1200

tgaatgatac tatatttggt ttcacaatgg aggagcgctc atgggggccc tatatcacct     1260

gtattcaggg cctatgtgcc aacaataatg acagaaccta ctgggaactt ctgagtggag     1320

gcgaaccact gagccaagga gctggtagtt acgttgtccg caatggagaa aacttggagg     1380

ttcgctggag caaatactaa taagcccaaa ctttcctcag ctgcataaaa tccatttgca     1440

gtggagttcc atgtttattg tccttatgcc ttcttcttca tttatcccag tacgagcagg     1500

agagttaata acctcccctt ctctctctac atgttcaata aaagttgttg aaagattaac     1560

aactataaaa aaaaaaa                                                    1577


<210>  79
<211>  7284
<212>  DNA
<213>  Homo sapiens

<400>  79
ctcacacttt tgctctcttg cagtcagttg ctttgctggc ttctgcaggc ttttaaggtc       60

tcgcggcgta gaaatgcctg gcccccaccc ccttcctcgg tctccccttt caattcagat      120

gtgctgatgt gcagaccgga ttcatcttct cggagctgcg gcggcggctt tgggctcagg      180

cggcggcggc tcgcgctcgg ccgcggagtc ctggcagcag cggggacgcg gcgcgggagt      240

ccgagctctg gtggcagctg agcccgcggg gcgccgctcg ccgagccgcg gccgcgggaa      300

gttcggcagc cagaaggacg acctggcagg ctgcgagcgc cagcgccgcc agagccgagt      360

ttgcctgcgc cctccccgcc tccgagtgca gagttcctta cctgccctcc gcccacccgt      420

gggcccctag ccaacttctc cctgcgactg ggggtaacag gcagtgcttg ccctctctac      480

tgtcccggcg gcatccacat gtttccggac acctgagcac cccggtcccg ccgaggagcc      540

tccgggtggg gagaagagca ccggtgcccc tagccccgca catcagcgcg gaccgcggct      600

gcctaacctc tgggtcccgt cccctccttt tcctccgggg gaggaggatg gggttgggaa      660

cgctttcccc gaggatgctc gtgtggctgg tggcctcggg gattgttttc tacggggagc      720

tatgggtctg cgctggcctc gattatgatt acacttttga tgggaacgaa gaggataaaa      780

cagagactat agattacaag gacccgtgta aagccgctgt attttggggc gatattgcct      840

tagatgatga agacttaaat atctttcaaa tagataggac aattgacctt acgcagaacc      900

cctttggaaa ccttggacat accacaggtg gacttggaga ccatgctatg tcaaagaagc      960

gaggggccct ctaccaactt atagacagga taagaagaat tggctttggc ttggagcaaa     1020

acaacacagt taagggaaaa gtacctctac aattctcagg gcaaaatgag aaaaatcgag     1080

ttcccagagc cgctacatca agaacggaaa gaatatggcc tggaggcgtt attccttatg     1140

ttataggagg aaacttcact ggcagccaga gagccatgtt caagcaggcc atgaggcact     1200

gggaaaagca cacatgtgtg actttcatag aaagaagtga tgaagagagt tacattgtat     1260

tcacctatag gccttgtgga tgctgctcct atgtaggtcg gcgaggaaat ggacctcagg     1320

caatctctat cggcaagaac tgtgataaat ttgggattgt tgttcatgaa ttgggtcatg     1380

tgataggctt ttggcatgaa cacacaagac cagatcgaga taaccacgta actatcataa     1440

gagaaaacat ccagccaggt caagagtaca attttctgaa gatggagcct ggagaagtaa     1500

actcacttgg agaaagatat gatttcgaca gtatcatgca ctatgccagg aacaccttct     1560

caagggggat gtttctggat accattctcc cctcccgtga tgataatggc atacgtcctg     1620

caattggtca gcgaacccgt ctaagcaaag gagatatcgc acaggcaaga aagctgtata     1680

gatgtccagc atgtggagaa actctacaag aatccaatgg caacctttcc tctccaggat     1740

ttcccaatgg ctacccttct tacacacact gcatctggag agtttctgtg accccagggg     1800

agaagattgt tttaaatttt acaacgatgg atctatacaa gagtagtttg tgctggtatg     1860

actatattga agtaagagac gggtactgga gaaaatcacc tctccttggt agattctgtg     1920

gggacaaatt gcctgaagtt cttacttcta cagacagcag aatgtggatt gagtttcgta     1980

gcagcagtaa ttgggtagga aaaggctttg cagctgtcta tgaagcgatc tgtggaggtg     2040

agatacgtaa aaatgaagga cagattcagt ctcccaatta tcctgatgac tatcgcccga     2100

tgaaagaatg tgtgtggaaa ataacagtgt ctgagagcta ccacgtcggg ctgacctttc     2160

agtcctttga gattgaaaga catgacaatt gtgcttatga ctacctggaa gttagagatg     2220

gaaccagtga aaatagccct ttgatagggc gtttctgtgg ttatgacaaa cctgaagaca     2280

taagatctac ctccaatact ttgtggatga agtttgtttc tgacggaact gtgaacaaag     2340

cagggtttgc tgctaacttt tttaaagagg aagatgagtg tgccaaacct gaccgtggag     2400

gctgtgagca gcgatgtctg aacactctgg gcagttacca gtgtgcctgt gagcctggct     2460

atgagctggg cccagacaga aggagctgtg aagctgcttg tggtggactt cttaccaaac     2520

ttaacggcac cataaccacc cctggctggc ccaaggagta ccctcctaat aagaactgtg     2580

tgtggcaagt ggttgcacca acccagtaca gaatttctgt gaagtttgag ttttttgaat     2640

tggaaggcaa tgaagtttgc aaatatgatt atgtggagat ctggagtggt ctttcctctg     2700

agtctaaact gcatggcaaa ttctgtggcg ctgaagtgcc tgaagtgatc acatcccagt     2760

tcaacaatat gagaattgaa ttcaaatctg acaatactgt atccaagaag ggcttcaaag     2820

cacatttttt ctcagacaaa gatgaatgct ctaaggataa tggtggatgt cagcacgaat     2880

gtgtcaacac gatggggagc tacatgtgtc aatgccgtaa tggatttgtg ctacatgaca     2940

ataaacatga ttgcaaggaa gctgagtgtg aacagaagat ccacagtcca agtggcctca     3000

tcaccagtcc caactggcca gacaagtacc caagcaggaa agaatgcact tgggaaatca     3060

gcgccactcc tggccaccga atcaaattag cctttagtga atttgagatt gagcagcatc     3120

aagaatgtgc ttatgaccac ttagaagtat ttgatggaga aacagaaaag tcaccgattc     3180

ttggacgact gtgtggcaac aagataccag atccccttgt ggctactgga aataaaatgt     3240

ttgttcggtt tgtttctgat gcatctgttc aaagaaaagg ctttcaagct acacattcta     3300

cagagtgtgg cggacgattg aaagcagaat caaaaccaag agatctgtac tcacatgctc     3360

agtttggtga taacaactac ccaggacagg ttgactgtga atggctatta gtatcagaac     3420

ggggctctcg acttgaatta tccttccaga catttgaagt ggaggaagaa gcagactgtg     3480

gctatgacta tgtggagctc tttgatggtc ttgattcaac agctgtgggg cttggtcgat     3540

tctgtggatc cgggccacca gaagagattt attcaattgg agattcagtt ttaattcatt     3600

tccacactga tgacacaatc aacaagaagg gatttcatat aagatacaaa agcataagat     3660

atccagatac cacacatacc aaaaaataac accaaaacct ctgtcagaac acaaaggaat     3720

gtgcataatg gagagaagac atattttttt taaaactgaa gatattggca caaatgtttt     3780

atacaaagag tttgaacaaa aaatccctgt aagaccagaa ttatctttgt actaaaagag     3840

aagtttccag caaaaccctc atcagcatta caaggatatt tgaactccat gcttgatggt     3900

attaataaag ctggtgaaag ggcatcatat acttcaagga agactctaca agcttttgtt     3960

cacagcttga aatagatgcc tcacaattca gacagtttaa ttcaggaact gtgaccctgc     4020

agtgttcttt ttgacaattt gtcaagattt agggacataa aatgatcttg caggtcgtaa     4080

actggaaaac agtattttgg ttgtcttagg ataattgctg actttgtatc ttggatacag     4140

tgtaaaccag atccatataa ggtgaatgtg aaatgggagt cttctgaggg tgatttgtac     4200

tttccatgtg tatgtgtgtg tctggtgttt ggaaactggg atatttcagc ttcattattt     4260

ccacttgcag gccagcttaa cctctgaaac acaaatgatc ttgagaccac tttagtgtac     4320

ttacatttag atgagtttga aatctcaatg gtgtctaatt attgcagtta aattctagac     4380

atcagttctt taagtctcag aaaacgccca gtgaattggt aaacttagtt cttttttttg     4440

gaagtgctgc cttttcacac caaatccaag aagcctgtga tgtcttatga accttatgag     4500

aaaactccga agaggtgtga gcaggattct tctgaatgac tgtctggatg gttcattact     4560

caagttactg ctgctgctat tgtctttcct ttgttgtcga tctgttattg ttgtattatt     4620

attgttgatg ttgtcatggt taatctattt tttaaaattg aaatgaagca gaagtaggcc     4680

ttgtgagaac tgaaaggtct ctttcatttt tctcttcctg ggattcattt tttcaaaaca     4740

caatgctgga aaaaaaagat ttgtttctga aagacttctt atggtgctat tccataaact     4800

ttttttcaaa caagtttttg acctttgagc caacccaccc gtagactacg aatgtctccc     4860

tatggctggt agcatttgaa gactaaagac ttgtcaaata tatcaagagt atatcattgc     4920

aagggcagca cttgtcctgt ggaacaacta cttataatgc cttagaattc ctgcacatga     4980

tcaaacagat cctcctaaaa cacacctttt gaaatgttga acataatagt gtatgttaat     5040

taacagctct atgaagaaaa tccatttcca tgactgaagc attggatata aatatggtgt     5100

cctgcttttt ttgtagaaaa tgtaatttga ggatgaattt tctgctttaa aggcatgtgt     5160

gtttttaaaa ttaatgaatg tagatgtgtg attgtctgag tgagtgaaac tacaagaggt     5220

aaaaaataat gggtggttga aaagttaaaa tgtatgtgcc aagttctact agaattccat     5280

ttgaaatagc accttcctta ggtttcatgg acaaataatg ggaacttcta attttgatca     5340

atcccattaa aaaaaggctc tttcctttag agaaactcta ttttgatgtc aatatagatt     5400

actgtatgaa gtagctttgt gtctgttacc tgtccatgag catacaacat tgaatacaat     5460

tgggtgtatt ctttcagttt tacacaatta aagtatacac acagatgtag cttatctgtt     5520

tttttcttaa attgttgccc tgaaaaaatt tcttgcatat gaattgtaaa atgtaaatac     5580

atttttataa ccaatgtttt gatcttattg aatgttactt tgaaaatgta taactattgc     5640

ctgcaatgta gatgagcctt ttagtagagc tgatttattc cagtaacttc ttccatattt     5700

tctcactaat ctcccgttag ccaaaatatg ccagaaatgg gaaagagagg agaaaaagtc     5760

attaacatta acacctatac tgttctatac tactcctacc cgtgtgctag gaatgtgcac     5820

tagctctttt taaattccat gctacacttt gaggactgtc atcatgttct cgttttgtag     5880

ttcagaaagt gaggctcaaa gaatttatgt aaccttccca gagtcacagt gtaaagttag     5940

atgttgaaac ccagtttatc ttatacaaat gagcctctgc ttgttctaca aaggtagtag     6000

aatcaatctc gacctatata aatagtagat tttttatggt gaaactttcc cacataaagt     6060

aaattttagg ggtgaattag agtaaaactt acaggataag cattttgctc tttttaagaa     6120

cagcatgaaa tttagaatac caatgatagc tatctttaag aatcagaatt agtactagaa     6180

atttaaaaaa ccctatagtt tggagttagt atgagccttt tgtgaaaata aatatattaa     6240

attattttgc ctgatgtggt aggggaaatg tattgctcta tattaagaaa tattctggat     6300

attctgattg acatcttatt aggccatagt gagctatgct ctgcacaact gagaaattag     6360

gtatttagaa ggcatataga gatgttgtca taactaggtc ttcaacgtga aaattaattt     6420

ttattgtatc atgtcaagta tcagtttacc acatattatt tttatattaa ttcaacattt     6480

gccttaagtg tgttgttaaa tgaaagtaca gacagcttca ttgttgtatt gttaataatt     6540

gttacttact gctccaggca ttttattaaa ttaatttttt aaattatttt ccaccctaca     6600

tcagtatatt ggttgtgctt tatatttgcc aaagtcctaa ctgactatac atagaaaaaa     6660

aaaaaaacac tgttctcact tgattttatt aaattatttt taaaagtcaa ttttgaaaat     6720

aactgtattt tattaaggag atcgtgactt aacttaaatg gacaaaataa ctttttaaaa     6780

gaaatggatg agaagtaatt gtgtttccaa aaccctcaaa tatcccattc ctatactggc     6840

tggatttttg ctacctgtcg ctcattttaa tatgtcacag tatgagattc aaattctgtt     6900

taactttgtt ttaaaatagc ttggtctctt ttatttggtt tgtaatactg ctgtattttt     6960

ggtggtaagc ttcaaatatc aaattttgtt ctgccatgta gaaaaatctc taaaagcatc     7020

aaatgactaa ttttattttt gcaaggttaa aatttatttt taaaagaaac attaaattat     7080

atctttatgt agatttagaa ggactgcaac cctatgtgac attataactt acttaaaaca     7140

gttatcaaat atttggaaac tattgtttac taataagaat aagacttgcc ttatggaaaa     7200

tttttgatac cacttgttaa atcaggcatg ggaggaggag agcagaaaat ataattgcct     7260

tctaaagata aaaaaaaaaa aaaa                                            7284


<210>  80
<211>  3722
<212>  DNA
<213>  Homo sapiens

<400>  80
aatcatttgc aaagttcaag ttccagagaa catttatttt gacaaccctc taggtgttgc       60

taggcttctg ggatatgaca gcattgcctt gtgttagcta gcaataagaa aagaagcttt      120

gtttggatta acatatatac cctcttcatt ctgcatacct attttttccc caataatttg      180

cagcttaggt ccgaggacac cacaaactct gcttaaaggg cctggaggct ctcaaggcat      240

ggccagacgc tctgtcttgt acttcatcct gctgaatgct ctgatcaaca agggccaagc      300

ctgcttctgt gatcactatg catggactca gtggaccagc tgctcaaaaa cttgcaattc      360

tggaacccag agcagacaca gacaaatagt agtagataag tactaccagg aaaacttttg      420

tgaacagatt tgcagcaagc aggagactag agaatgtaac tggcaaagat gccccatcaa      480

ctgcctcctg ggagattttg gaccatggtc agactgtgac ccttgtattg aaaaacagtc      540

taaagttaga tctgtcttgc gtcccagtca gtttggggga cagccatgca ctgcgcctct      600

ggtagccttt caaccatgca ttccatctaa gctctgcaaa attgaagagg ctgactgcaa      660

gaataaattt cgctgtgaca gtggccgctg cattgccaga aagttagaat gcaatggaga      720

aaatgactgt ggagacaatt cagatgaaag ggactgtggg aggacaaagg cagtatgcac      780

acggaagtat aatcccatcc ctagtgtaca gttgatgggc aatgggtttc attttctggc      840

aggagagccc agaggagaag tccttgataa ctctttcact ggaggaatat gtaaaactgt      900

caaaagcagt aggacaagta atccataccg tgttccggcc aatctggaaa atgtcggctt      960

tgaggtacaa actgcagaag atgacttgaa aacagatttc tacaaggatt taacttctct     1020

tggacacaat gaaaatcaac aaggctcatt ctcaagtcag ggggggagct ctttcagtgt     1080

accaattttt tattcctcaa agagaagtga aaatatcaac cataattctg ccttcaaaca     1140

agccattcaa gcctctcaca aaaaggattc tagttttatt aggatccata aagtgatgaa     1200

agtcttaaac ttcacaacga aagctaaaga tctgcacctt tctgatgtct ttttgaaagc     1260

acttaaccat ctgcctctag aatacaactc tgctttgtac agccgaatat tcgatgactt     1320

tgggactcat tacttcacct ctggctccct gggaggcgtg tatgaccttc tctatcagtt     1380

tagcagtgag gaactaaaga actcaggttt aaccgaggaa gaagccaaac actgtgtcag     1440

gattgaaaca aagaaacgcg ttttatttgc taagaaaaca aaagtggaac ataggtgcac     1500

caccaacaag ctgtcagaga aacatgaagg ttcatttata cagggagcag agaaatccat     1560

atccctgatt cgaggtggaa ggagtgaata tggagcagct ttggcatggg agaaagggag     1620

ctctggtctg gaggagaaga cattttctga gtggttagaa tcagtgaagg aaaatcctgc     1680

tgtgattgac tttgagcttg cccccatcgt ggacttggta agaaacatcc cctgtgcagt     1740

gacaaaacgg aacaacctca ggaaagcttt gcaagagtat gcagccaagt tcgatccttg     1800

ccagtgtgct ccatgcccta ataatggccg acccaccctc tcagggactg aatgtctgtg     1860

tgtgtgtcag agtggcacct atggtgagaa ctgtgagaaa cagtctccag attataaatc     1920

caatgcagta gacggacagt ggggttgttg gtcttcctgg agtacctgtg atgctactta     1980

taagagatcg agaacccgag aatgcaataa tcctgccccc caacgaggag ggaaacgctg     2040

tgagggggag aagcgacaag aggaagactg cacattttca atcatggaaa acaatggaca     2100

accatgtatc aatgatgacg aagaaatgaa agaggtcgat cttcctgaga tagaagcaga     2160

ttccgggtgt cctcagccag ttcctccaga aaatggattt atccggaatg aaaagcaact     2220

atacttggtt ggagaagatg ttgaaatttc atgccttact ggctttgaaa ctgttggata     2280

ccagtacttc agatgcttac cagacgggac ctggagacaa ggggatgtgg aatgccaacg     2340

gacggagtgc atcaagccag ttgtgcagga agtcctgaca attacaccat ttcagagatt     2400

gtatagaatt ggtgaatcca ttgagctaac ttgccccaaa ggctttgttg ttgctgggcc     2460

atcaaggtac acatgccagg ggaattcctg gacaccaccc atttcaaact ctctcacctg     2520

tgaaaaagat actctaacaa aattaaaagg ccattgtcag ctgggacaga aacaatcagg     2580

atctgaatgc atttgtatgt ctccagaaga agactgtagc catcattcag aagatctctg     2640

tgtgtttgac acagactcca acgattactt tacttcaccc gcttgtaagt ttttggctga     2700

gaaatgttta aataatcagc aactccattt tctacatatt ggttcctgcc aagacggccg     2760

ccagttagaa tggggtcttg aaaggacaag actttcatcc aacagcacaa agaaagaatc     2820

ctgtggctat gacacctgct atgactggga aaaatgttca gcctccactt ccaaatgtgt     2880

ctgcctattg cccccacagt gcttcaaggg tggaaaccaa ctctactgtg tcaaaatggg     2940

atcatcaaca agtgagaaaa cattgaacat ctgtgaagtg ggaactataa gatgtgcaaa     3000

caggaagatg gaaatactgc atcctggaaa gtgtttggcc tagcacaatt actgctaggc     3060

ccagcacaat gaacagattt accatcccga agaaccaact cctacaaatg agaattcttg     3120

cacaaacagc agactggcat gctcaaagtt actgacaaaa attattttct gttagtttga     3180

gatcattatt ctcccctgac tctcctgttt gggcatgtct tattcagttc cagctcatga     3240

cgccctgtag cataccccta ggtaccaact tccacagcag tctcgtaaat tctcctgttc     3300

acattgtaca aaaataatgt gacttctgag gcccttatgt agcctgtgac attaagcatt     3360

ctcgcaatta gaaataagaa taaaacccat aattttcttc aatgagttaa taaacagaaa     3420

tctccagaac ctctgaaaca cattcttgaa gcccagcttt catatcttca ttcaacaaat     3480

aatttctgag tgtgtataca ggatgtcaag tactgaccaa agtcctgaga actcggcaga     3540

taataaaaca gacaaaagcc tttgccttca tgaagcatac attcattcag gggtagacac     3600

acaaaaaatg aaataaacag gtaaaatatg tagcatgttt gatggtgata attgttttgg     3660

agaaaataca acacggaagg gtgagtccca tccttaatta tcatcttatg caaggaaata     3720

tt                                                                    3722


<210>  81
<211>  2060
<212>  DNA
<213>  Homo sapiens

<400>  81
acctgggtcg ggtgcagact gcggagcggg ccctaccgtg tgcgcagaaa gaggaggcgc       60

ttgccttcag cttgtgggaa atcccgaaga tggccaaaga caactcaact gttcgttgct      120

tccagggcct gctgattttt ggaaatgtga ttattggttg ttgcggcatt gccctgactg      180

cggagtgcat cttctttgta tctgaccaac acagcctcta cccactgctt gaagccaccg      240

acaacgatga catctatggg gctgcctgga tcggcatatt tgtgggcatc tgcctcttct      300

gcctgtctgt tctaggcatt gtaggcatca tgaagtccag caggaaaatt cttctggcgt      360

atttcattct gatgtttata gtatatgcct ttgaagtggc atcttgtatc acagcagcaa      420

cacaacaaga ctttttcaca cccaacctct tcctgaagca gatgctagag aggtaccaaa      480

acaacagccc tccaaacaat gatgaccagt ggaaaaacaa tggagtcacc aaaacctggg      540

acaggctcat gctccaggac aattgctgtg gcgtaaatgg tccatcagac tggcaaaaat      600

acacatctgc cttccggact gagaataatg atgctgacta tccctggcct cgtcaatgct      660

gtgttatgaa caatcttaaa gaacctctca acctggaggc ttgtaaacta ggcgtgcctg      720

gtttttatca caatcagggc tgctatgaac tgatctctgg tccaatgaac cgacacgcct      780

ggggggttgc ctggtttgga tttgccattc tctgctggac tttttgggtt ctcctgggta      840

ccatgttcta ctggagcaga attgaatatt aagcataaag tgttgccacc atacctcctt      900

ccccgagtga ctctggattt ggtgctggaa ccagctctct cctaatattc cacgtttgtg      960

ccccacacta acgtgtgtgt cttacattgc caagtcagat ggtacggact tcctttagga     1020

tctcaggctt ctgcagttct catgactcct acttttcatc ctagtctagc attctgcaac     1080

atttatatag actgttgaaa ggagaatttg aaaaatgcat aataactact tccatccctg     1140

cttattttta atttgggaaa ataaatacat tcgaaggaac ctgtgttatc acagtaaccc     1200

agagctgtat ttggctagca atctgcctgt atctctcact attatctaaa agaaaccttc     1260

caatgcttct gttgatctca gtattgtcag gggaacagag aagttgggaa aagattactg     1320

aaatatacct tttgcatttc tttctagagt agctcccata tatggagatg ggtgattctc     1380

ttgatgccac cttcagatcc ttttattctc cagaataatt cttaacagtg gttcaaattt     1440

cctttcatac cttgaagtat gtgtttagta gcctcaattc tccattaatt aaaagtgtgg     1500

gctgggcgtg ggggctcatg cctgtaatcc cagcactttg ggaggccgag gtgggcagat     1560

cacctgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc gtctctacaa     1620

aaatacaaaa attagccagg cgtgatggca ggtgcctgta atcctagcta cttggcaggc     1680

taacgcagga gaatcacttg accgggagac agaggttgca gtgagctgag atcgtaccta     1740

ttgcactcca tcctggatga aagagccaga ctctgtctca aaacaaacaa aaaagcgtgg     1800

ggacttctgg ggacagacaa ggtgcctgtt atatatttac tcagtctttg ccctgaatgg     1860

tctcagcttg agaccatttc aaactggaga gaagcaagcc agccaataga atggggtgat     1920

ttacagggat ttctgtttac tgtcaaaata tttctcatct gcactatgtt tccatttgtg     1980

gtcctgaagg aaattcttat aactcaacat ttgtctggtc ttataagtaa agacagcttt     2040

aaaatctgtt cactttcaaa                                                 2060


<210>  82
<211>  1484
<212>  DNA
<213>  Homo sapiens

<400>  82
cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg       60

ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg      120

gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc      180

tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagcaa tgttgcgctt      240

gtacgtgttg gtaatgggag tttctgcctt cacccttcag cctgcggcac acacaggggc      300

tgccagaagc tgccggtttc gtgggaggca ttacaagcgg gagttcaggc tggaagggga      360

gcctgtagcc ctgaggtgcc cccaggtgcc ctactggttg tgggcctctg tcagcccccg      420

catcaacctg acatggcata aaaatgactc tgctaggacg gtcccaggag aagaagagac      480

acggatgtgg gcccaggacg gtgctctgtg gcttctgcca gccttgcagg aggactctgg      540

cacctacgtc tgcactacta gaaatgcttc ttactgtgac aaaatgtcca ttgagctcag      600

agtttttgag aatacagatg ctttcctgcc gttcatctca tacccgcaaa ttttaacctt      660

gtcaacctct ggggtattag tatgccctga cctgagtgaa ttcacccgtg acaaaactga      720

cgtgaagatt caatggtaca aggattctct tcttttggat aaagacaatg agaaatttct      780

aagtgtgagg gggaccactc acttactcgt acacgatgtg gccctggaag atgctggcta      840

ttaccgctgt gtcctgacat ttgcccatga aggccagcaa tacaacatca ctaggagtat      900

tgagctacgc atcaagaaaa aaaaagaaga gaccattcct gtgatcattt cccccctcaa      960

gaccatatca gcttctctgg ggtcaagact gacaatcccg tgtaaggtgt ttctgggaac     1020

cggcacaccc ttaaccacca tgctgtggtg gacggccaat gacacccaca tagagagcgc     1080

ctacccggga ggccgcgtga ccgaggggcc acgccaggaa tattcagaaa ataatgagaa     1140

ctacattgaa gtgccattga tttttgatcc tgtcacaaga gaggatttgc acatggattt     1200

taaatgtgtt gtccataata ccctgagttt tcagacacta cgcaccacag tcaaggaagc     1260

ctcctccacg ttctcctggg gcattgtgct ggccccactt tcactggcct tcttggtttt     1320

ggggggaata tggatgcaca gacggtgcaa acacagaact ggaaaagcag atggtctgac     1380

tgtgctatgg cctcatcatc aagactttca atcctatccc aagtgaaata aatggaatga     1440

aataattcaa acacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1484


<210>  83
<211>  2911
<212>  DNA
<213>  Homo sapiens

<400>  83
ccgcgagaga gtggagctaa ctgagcagcg cacccgccac ggccgctgcc gccccgtgcg       60

cccggctctc ccagcacccc gcgcggcgct ccagccaggc gcctgtgcga ctagcggcgg      120

ccggcgaagc ccgcgccagc cccgcgggtc gctgcggcat cctcccgccg cccagccccc      180

gcacgctccc tgcagtttaa aaggacctcc cgccgcttct cggcgctgcc ccgggattcc      240

ccagccccgc gcggctccct actccacttc gcagcaactt cggcgaccgc gcgccgcccg      300

ccctcgcccg cctttgaagt ttgctgtgcc gaccgcaaag ttgggacact tcagcggatt      360

gaatttttct cttttatctg cctccgtccc cgccctccag gcttctcgtt cctggatatt      420

ggtgcttagc atcttggcag ggtccgggga cgtggactat ttcgcacacc acaccacggg      480

gagggatttt tttctatttt ccctacgaaa aacagatctt tttaaggatg gtgctgctcc      540

actggtgcct gctgtggctc ctgtttccac tcagctcaag gacccagaag ttacccaccc      600

gggatgagga actttttcag atgcagatcc gggacaaggc attttttcat gattcgtcag      660

taattccaga tggagctgaa attagcagtt atctctttag agatacacct aagaggtatt      720

tctttgtggt tgaagaagac aatactccat tatcagtcac agtgacgccc tgtgatgcgc      780

ctttggagtg gaagctgagc ctccaggagc tgccagagga caggagcggg gaaggctcag      840

gtgatctgga acctcttgag cagcagaagc agcagatcat taatgaggaa ggcactgagt      900

tattctccta caaaggcaat gatgttgagt attttatatc gtctagttcc ccatccggtt      960

tatatcagtt ggatcttctt tcaacagaga aagacacaca tttcaaagta tatgccacca     1020

caactccaga atctgatcag ccataccctg agttacccta tgacccaaga gtagatgtga     1080

cctcactggg gcgcaccacg gtcactttgg cctggaaacc aagccccact gcctctttgc     1140

tgaaacaacc cattcagtac tgtgtggtca tcaacaaaga gcacaatttc aaaagtctct     1200

gtgcagtgga agcaaaactg agtgcagatg atgcttttat gatggcaccg aaacctggtc     1260

tggacttcag cccctttgac tttgcccact ttggatttcc ttctgataat tcaggtaaag     1320

aacgcagttt ccaggcaaag ccttctccaa aactggggcg tcatgtctac tccaggccca     1380

aggttgatat tcagaaaatc tgcataggaa acaagaacat cttcaccgtc tctgatctga     1440

aacccgacac gcagtactac tttgatgtat ttgtggtcaa catcaacagc aacatgagca     1500

ccgcttatgt aggtaccttt gccaggacca aggaagaagc caaacagaag acagtcgagc     1560

taaaagatgg gaagataaca gatgtatttg ttaaaaggaa gggagcaaag tttctacggt     1620

ttgctccagt ctcttctcac caaaaagtca ccttctttat tcactcttgt ctggatgctg     1680

tccaaatcca agtgagaaga gatgggaaac ttcttctgtc tcagaatgtg gaaggcattc     1740

agcagtttca gcttagagga aaacctaaag ctaaatacct cgttcgactg aaaggaaaca     1800

agaaaggagc atctatgttg aaaattctag ctaccacaag gcctactaag cagtcatttc     1860

cctctcttcc tgaagacaca agaatcaaag cctttgacaa gctccgtacc tgttcctcag     1920

ccaccgtggc ttggctaggc actcaggaaa ggaacaagtt ttgcatctac aaaaaagaag     1980

tggatgataa ctacaatgaa gaccagaaga aaagagagca aaaccaatgt ctaggaccag     2040

atataaggaa gaagtcagaa aaggtcctct gtaaatattt ccacagtcaa aacctgcaga     2100

aagcagtgac cacagaaaca attaaaggtc ttcagcctgg caaatcttac ctgctggatg     2160

tttatgtcat aggacatggg gggcactctg taaagtatca gagtaaggtt gtgaaaacta     2220

gaaagttctg ttagttacct tcttatagag atatattatg tagaactcca ggagggacat     2280

taaatcactt taagtataaa ctgactactc ccacagttga gagaagttgt gacctgtact     2340

tgtactatgg aaggaaggat atcaacgtgt gtatattgat gtttatataa gtaactcttg     2400

aaggagactt gttctagcgt gccccatggt acctagtgtg tgtctgatgc cggttggtgt     2460

caaagataga gggcttcttg aaggaacttg ccattccttg ctttgaccac tgcatgaact     2520

gcttctaaat tattttatta cctaaaaatt taaaatatgc cattcattgc acacacccac     2580

aaatgcaaat cattcctctc tgtagatgct aggatatata taaattattt tataaattct     2640

tgttttaaat gtcagtgttt ctatgattgt aaactattaa attcttttcc tattaaagta     2700

cagatctaat ctaagtatta ttaagttgat agccctctag tcagttatat tgctattgta     2760

aattcttgtt tgttgagtaa aatgtttaaa tactatatgt atctcatgta caaagttgac     2820

atacattata ttcatgtaca taaaattaaa gagattagat tatatactgt taaaaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    2911


<210>  84
<211>  3606
<212>  DNA
<213>  Homo sapiens

<400>  84
aaaggtgact agagtgctaa gccagtcaac agggaaaact tggctcctga ctttgggtct       60

ttcttctcag tctatatgga agaaaactga gaaaaaatat aaaaaagaag aacacaacta      120

gttgcgcatc tcctaaagag atggaatcgc cacttatata tgtttcagtt ttgcttttga      180

acatatttga attttcatca ggaatagtat ataataaaga tgatacagag aaacgctttg      240

catgttctaa caaagggttc cctcaagaga atgaaataat caagttgtat cttttcttag      300

aaaacttgaa aatccagtgt ttcttccaaa ctgaaaatga aattgcatca aaagcaatgc      360

taagtgtgtt cacatcagga ggacttgctc ccagcttggg aatcatgaat agtacatata      420

atggcatctt ccactttaat ttaacgttgt tcagtgatcg gattttgtgg ttggttgata      480

ttcctagaga aaacatcaca caaagcacag atattgcagc tgtagaagaa tggttagtaa      540

gaatcacttt acatcatgga ctaaatattt atgctactga aggaactcta ttggatgtta      600

ttcgagaacc gattcttcag tggactcctg gggatgtgat tccagaaagt gaaatcagta      660

aattatatcc acatgtggta gatctcaaag tgacaaaatg cccctgtgcc aatgatgtgg      720

cattactagg cttcattgtg gatacaatag ttgatggtgt ttacataggc ataacctttg      780

gtggattctg gcatgattat gataccacat ggtttaacat gacacagact atctattccc      840

aacttcaaga agaatatgaa gacctttcat tggtggatat ggttttaacg aatcattttt      900

tagttatcct cacctctttg ggcctttttg taagtgaaga tcttcgttat ccatcacgcc      960

acagcttatc gttttccagg gcagactttt gtggttttga aagggttgac tatgtgaaag     1020

gaaaactgtg gtataatgaa agatgttttg ctaacagaga gcactttgaa gttgattatg     1080

ttacagttac ctttgagaga aacagaaccc taagtgagtc aagctcttgt ttttatagtc     1140

aggaaccatt tcttgaatgg gtaccctgct tacctcacat ttttaaagga ataaaaattt     1200

ttccaactgt gctaacattt cttgttgacc aagagcgtgg tactggagtt tacctcttct     1260

ataacaaggt caggaaaact gccattgcct ctgtgagcac cctgagaaat aatgaaccaa     1320

attcacaatc aaaatttcca atttttcggt ttccttcatc attctcttct cccgttggaa     1380

tggtatttca tccccgaagc cactttttgt atgcttatgg caatcagata tggctttcag     1440

ttgatggcgg caacaccttt caattaatag ctaactttca tgatgatatc ataaagaaga     1500

cttttcatag tttttataca tcagctatta cttttgtttc tcaacgtgga aaggtttact     1560

cgacaaaggc aggaatggga agatacagtg cagtcggaag tgttactgag agaattttca     1620

cattatacta tgatcacttg ggattcctac ataagctgac tctgggtcgc tttgaagcta     1680

gtggaccacc cacagccttt ggaaattcta gaaatctttt tggacagcct ccagatatgg     1740

gctttgagac tgcgcttgcc ccacagcaca cctccttaga tgaaattatc ttttttgcat     1800

atgtacctga gaacgaaccc caggaaacga tctacagcaa gaagttcggc aatatacact     1860

atggaaaagt gatacactct gggaaaactg gaagagctta cataagaaag gtattgcaac     1920

atacgactcc taaaggattt ttgtcctcag ttattgcaga aatgaaagag ccctttggat     1980

tagaagaagt gaatgagagc tcttgtttgt ctagttccct tttgattaat aaagctggaa     2040

atgtctataa actcactctt gattcacaag ttgttcaggc cttgtttgaa gatacagata     2100

tagagaagac tgtagtgctt cccgggtaca gcagcttcct catcacaagc attttagata     2160

ataagaatgc attagccatt gctaccatgc ctgaaagtgc acccaacaat atgacctttc     2220

taaagagcac atggttctta tacaactttg ggcaaaggaa tggacgaaca tggaaaatat     2280

attcaaaacc atgtaattat tggtttcaac atgatgattc accatccctc aacattgtga     2340

aatacattga tctgggaaac tcttatgttt taaaagctaa ggtcatacgg aatgcaaaag     2400

gttttcgaat gcttgaaata ccactactga ctgtgtttgt tggaaaccct aatttgttgg     2460

aagttacagc tgaagtcact tttgatgata ctgacagtta tgtaataaca atttctgcag     2520

ctagcaaagt tttacatcag ggttcaactt cactggcatt tattatgtgg tcagcctcta     2580

ctgagtgctt tgttacgaca atggtgccaa cactgaaaag cagctgtagt tatctcagat     2640

ctatgcatca cattcctagc aaatttatcc catttgaaga ctggattagt ggagttcata     2700

aagacagtca gggttttaac ctcatcaaaa ctttgccgat aaactacagg cctccatcta     2760

atatgggaat tgctattcca ctcacagata atttttatca tgcagatcct agcaaaccca     2820

taccaagaaa catgtttcac atgtcaaaga aaaccggtaa attcaaacag tgtgctaatg     2880

tttccactcg ggaggagtgt aactgcacaa aggatcagaa gttttcacat gctgttgctt     2940

tctcggattg cagggaaaaa gttcctcgct ttaagtttcc aattacacaa tatccagttt     3000

ctttggaaat tatcaacgag gatggacgtg tcccattgca atctccatat ctggttactg     3060

tgactgaagt gaacatgagg cacaactgga aactgaaaca cactgtgcca gaaaatatta     3120

aaagaatgaa acaattagta gaaccaattc ttggtgctgc agtgtataat ccttcaggtc     3180

tcaacttaag cataaagggc tctgaacttt tccactttag agtgaccgtc atttcaggag     3240

taactttttg taacttaatt gaagaatttc agatttatgt tgatgaggca ccattgccat     3300

tcccaggaca cacgcttatt gccgtggcaa cagcggtagt gctaggggga ttaattttta     3360

tagcatttat gtttcaactg caaggcatcc atccgtggag gacattccaa agatggatta     3420

gaagaaacca agagaagttt tcaagtatct ctctcagtga gctgattcat agatcaaagt     3480

ctgaagagtg aacacatggt gatcataatt tctctttatt ttctagtttt atcagccaat     3540

tcctagaaca atatatttaa atgttaaata tgcaagctac ataaaatcct aaagaattgt     3600

cattat                                                                3606


<210>  85
<211>  4942
<212>  DNA
<213>  Homo sapiens

<400>  85
gctgcggctg cggcctcccc tgcgcgcagc tacccgggcg tcccggcccg cggccccgct       60

aaccccgggg cccgcgcccc cgcggcaggg atgcatcatg gccacgctgg cttgccgggt      120

gcagttcttg gacgacacgg accctttcaa cagcaccaac ttccccgagc ccagccggcc      180

gccgctgttc acgttccgcg aggacctcgc gctcggcacc cagctggcgg gggtccatag      240

gctgctgcag gcgccgcaca agctggatga ctgtactctg cagctctctc acaatggcgc      300

ctacctggat ttggaggcca ccctggcaga gcagcgggat gagttggaag gcttccagga      360

tgacgccggg cggggcaaga agcacagcat catcctaagg acgcagctgt ctgtgagggt      420

ccatgcctgc atcgaaaaac tatacaactc cagcggacga gatttgagaa gggccctctt      480

ctccctgaag cagatatttc aggatgacaa ggatttggtg catgaatttg tagtggctga      540

aggtctgaca tgtttgatca aggtgggagc tgaggctgat cagaactatc agaactacat      600

cttaagggct ttgggccaga ttatgttgta tgtggatgga atgaatggag taataaaccg      660

caatgaaacc attcagtggc tgtacactct cattgggtca aagttccgcc tggtggtgaa      720

gacagccctg aagctgctgc tcgtctttgt agagtactcg gagtccaacg cacctctcct      780

aattcaggct gtcactgctg ttgacacgaa aagaggggtc aaaccttggt caaatatcat      840

ggaaatcctg gaggaaaaag atggagttga tacggagcta ctggtttatg caatgacttt      900

ggtgaacaag acgttatcag gactaccaga ccaagacacc ttctacgacg tcgtggactg      960

cctggaggag ctgggcattg ctgctgtgtc ccagaggcac ttgaacaaga aagggactga     1020

cctggactta gtggagcaac tcaacattta tgaggtggcg ctcaggcacg aggatggcga     1080

tgagaccacg gagccacccc ccagtgggtg ccgggaccgg aggagggcca gcgtgtgttc     1140

cagtggcgga ggcgagcacc ggggcctgga ccgcagaagg agccgcaggc actcggtgca     1200

gagcatcaag agcaccctgt cggcccccac cagtccctgc tcccagtcag ctcccagctt     1260

caagcccaac caagtgcgag atctgcgtga aaaatacagc aattttggca ataactctta     1320

tcactcctca agaccctcat ctggatccag tgtgcccacc acccccacat catccgtctc     1380

acccccacag gaggccaggt tggaaaggtc atcaccgagt ggtcttctca catcatcctt     1440

caggcagcac caagagtcac tggcagcaga gagagagagg cggcggcagg agagagaaga     1500

aaggttgcag agaatagagc gggaagaaag aaacaaattc agccgagatt atttagacaa     1560

aagagaggag caaaggcaag caagagaaga aagatacaaa tacttggaac agttggcagc     1620

tgaggagcac gagaaggagc tgagaagccg gagtgtgagc cggggcagag ccgacctctc     1680

cttggacctg acctcgccag cagccccagc ctgcctggct cctctgagcc atagcccctc     1740

atcttcagac tctcaagagg ctctcacggt gtctgcctcc tccccaggaa cccctcacca     1800

tccccaagca agtgccgggg atcctgaacc cgaatcagag gcagaaccgg aagcagaggc     1860

aggggcgggg caggttgctg atgaagctgg ccaggacata gcctctgccc acgagggtgc     1920

agagactgaa gtggagcagg cactagagca agagccggaa gaaagagcct ccctcagtga     1980

aaaagagagg cagaacgagg gggtgaacga gagggacaac tgctctgcct ccagcgtctc     2040

gtcctccagc agcacgttgg agagggagga gaaggaggac aagctctcca gggacaggac     2100

aactggtttg tggcccgcag gtgtccagga tgcaggtgta aatggacagt gtggcgacat     2160

cctcaccaac aaacggttca tgcttgacat gctgtatgcc cataacagga agtctccgga     2220

tgatgaggag aagggggatg gggaggctgg gaggacccag caggaggcag aggcggtagc     2280

cagccttgct accaggatat ccaccctgca ggccaactct cagacccagg atgagagtgt     2340

caggagggtg gatgtcggct gtttggacaa tcggggcagt gtgaaagcat ttgctgagaa     2400

attcaacagt ggggacctgg ggagaggttc catctcccct gatgctgagc ccaatgacaa     2460

ggtcccagaa acagcgccgg tgcagccgaa gacagagtct gattacatct gggaccagct     2520

catggccaat ccaagagagc tcagaatcca agacatggat ttcactgacc tgggggagga     2580

ggatgacatt gatgtcctag atgtggacct gggtcacagg gaggcccctg ggccacctcc     2640

cccaccccca cccacctttc tgggtttgcc gcccccaccc cctccgcccc tgttggacag     2700

cattcctccc cctcctgtcc ctggtaattt attggttcct cctcctccag tgttcaacgc     2760

tcctcagggc ttagggtggt cccaggtacc caggggtcag cccacattca ctaagaaaaa     2820

gaagaccatc cgtttgttct ggaatgaagt tcggcctttt gactggccat gtaaaaacaa     2880

ccgacgctgc agagaattcc tgtggtcaaa actggaaccc attaaggtgg acacttccag     2940

actggagcac ctgtttgagt ctaaatccaa ggaactgtct gtctcaaaga aaactgctgc     3000

agatggaaaa aggcaagaga tcattgttct ggattccaag aggagtaacg ccatcaatat     3060

tggtctgacg gtgctgcccc ctccaaggac gattaagatc gccattttga attttgatga     3120

gtatgcctta aacaaagaag gaatcgagaa aattctaacg atgattccca ccgatgagga     3180

gaagcagaaa atccaggaag ctcagctggc caaccctgaa atccccctgg gcagtgcaga     3240

gcagttcctc ctcaccctgt cctccatcag cgagctctct gcacgacttc acctctgggc     3300

attcaaaatg gattatgaaa ctacagaaaa ggaagtagca gaaccactcc tggacctgaa     3360

ggaaggaata gaccagttgg agaacaataa aaccttgggc tttatcctgt ctactctctt     3420

agccattggg aactttctaa atggaactaa tgccaaagcg tttgagttaa gctacctcga     3480

gaaggttcca gaagtcaaag acacagtgca caagcagtcg cttctccacc atgtgtgcac     3540

catggtggta gaaaacttcc cagacagctc cgatctgtac tcggagatcg gggccatcac     3600

caggtcagcc aaggttgact ttgatcaact tcaggataat ttatgtcaga tggagagaag     3660

atgcaaagct tcatgggatc acctcaaggc aattgcaaaa catgaaatga aaccagtttt     3720

aaaacaacgg atgtcagagt tcctgaaaga ctgtgcagag cgaattataa ttttaaagat     3780

tgtccataga aggataatca acagattcca ctccttttta ctctttatgg gccatccacc     3840

ttatgcaatt cgggaagtga acataaacaa attctgcagg attattagtg aatttgcact     3900

agagtatcgc acaaccaggg aaagggtttt gcagcagaaa cagaaacggg ccaaccacag     3960

agagagaaat aagaccagag ggaagatgat caccgattct ggcaagttct ccggcagttc     4020

tccggcgccc ccaagccagc cgcagggtct gagctatgcg gaggacgcgg ctgagcacga     4080

gaacatgaag gctgtgctga aaacctcgtc cccctccgtg gaggacgcca cccccgcgct     4140

gggcgtccgc acacgcagcc gagcaagccg aggatccact agttcctgga ctatgggaac     4200

tgatgactcg cccaatgtca cagatgatgc agctgatgag atcatggacc gcatcgtcaa     4260

gtcagccacc caagtgccca gtcagcgagt ggtgccgagg gagaggaaac gatcccgggc     4320

caaccggaaa tctttgcgaa gaaccctgaa gagcggcctg accccagaag aagccagagc     4380

cctgggcttg gttggcacct cggagttgca gctgtgacac tcataggtta ctcccaggag     4440

tgtgctgagc agaaggcaag ctcttgctgg atgaaacccc tccaggtggg gttggggaga     4500

cttgatattc acatccaaca gtttgaaaag ggagagctca attcccagcg tcaccccatg     4560

gcttgtgttg cctgctacgc attgacttgg atctccagga gtcccctgca cataccttct     4620

ccatcgtgtc agctgtgttt ctcttgattc cgtgacaccc ggtttattag ttcaaaagtg     4680

tgacaccttt tctgggcaag gaacagcccc tttaaggagc aaatcacttc tgtcacagtt     4740

attatggtaa tatgaggcaa tctgattagc ttcacagact gagtctccac aacaccaaaa     4800

tatccagatg taaaccccaa acttgtacac aaaagaaagc acagattgtt tacctgttgt     4860

ggattttaga tgtaacaaat gtttatacaa atacatacat gtacaccatg tttcaaatac     4920

taaataaata gagtttaatg cc                                              4942


<210>  86
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  86
gttctggttt catagcaact tctaggtggt gtgggcgaag tttgggactg gtttagggcg       60

gggacaagac caagaacaca agtttccttg tactacggga gagagggagg ggaggaaatt      120

ggagacccca gcaccccctt gctcactctc ttgctcacag tccacgatgg cccggtccct      180

ggtgtgcctt ggtgtcatca tcttgctgtc tgccttctcc ggacctggtg tcaggggtgg      240

tcctatgccc aagctggctg accggaagct gtgtgcggac caggagtgca gccaccctat      300

ctccatggct gtggcccttc aggactacat ggcccccgac tgccgattcc tgaccattca      360

ccggggccaa gtggtgtatg tcttctccaa gctgaagggc cgtgggcggc tcttctgggg      420

aggcagcgtt cagggagatt actatggaga tctggctgct cgcctgggct atttccccag      480

tagcattgtc cgagaggacc agaccctgaa acctggcaaa gtcgatgtga agacagacaa      540

atgggatttc tactgccagt gagctcagcc taccgctggc cctgccgttt cccctccttg      600

gctttatgca aatacaatca gcccagtgca aacggaaaaa aaaaaaaaaa aaaa            654


<210>  87
<211>  839
<212>  DNA
<213>  Homo sapiens

<400>  87
gcgtgaccag agcgcgctgg cccggcccac ccggggcggt tgtggtcgct atatataagg       60

tggggaggcc gccggcccgt tcggttccgg gcgttaccat cgtccgtgcg caccgcccgg      120

cgtccagatt tggcaattct tcgctgaagt catcatgagc tttttccaac tcctgatgaa      180

aaggaaggaa ctcattccct tggtggtgtt catgactgtg gcggcgggtg gagcctcatc      240

tttcgctgtg tattctcttt ggaaaaccga tgtgatcctt gatcgaaaaa aaaatccaga      300

accttgggaa actgtggacc ctactgtacc tcaaaagctt ataacaatca accaacaatg      360

gaaacccatt gaagagttgc aaaatgtcca aagggtgacc aaatgacgag ccctcgcctc      420

tttcttctga agagtactct ataaatctag tggaaacatt tctgcacaaa ctagattctg      480

gacaccagtg tgcggaaatg cttctgctac atttttaggg tttgtctaca ttttttgggc      540

tctggataag gaattaaagg agtgcagcaa taactgcact gtctaaaagt ttgtgcttat      600

tttcttgtaa atttgaatat tgcatattga aatttttgtt tatgatctat gaatgttttt      660

cttaaaattt acaaagcttt gtaaattaga ttttctttaa taaaatgcca tttgtgcaag      720

atttctcaaa gattaggtat atatttaaat ggaagagaaa atatttttat gggagaaaaa      780

tacatttgaa ccatgaaatt tcatctttta aataacatcc agtacagatt tctgtgtaa       839


<210>  88
<211>  3881
<212>  DNA
<213>  Homo sapiens

<400>  88
tcctcgctca ccttaaaacc atcgtgcatc accatggcga gttgctcctt cactcgcgac       60

caagcgacaa gaagactaag aggtgcagca gcggcggcag cggcagctct agcagcagtg      120

gtgaccaccc cgcttctttc ctcgggaacc ccgaccgcac tcattgggac cgggtcgtct      180

tgtccgggag ccatgtggct ctccacggcc actggctccc ggtcagactc cgagtccgaa      240

gaggaggacc tgcccgtcgg ggaggaagtc tgcaaacgcg gctacctgcg gaaacagaag      300

catgggcaca ggcgctactt cgtgctcaaa ctcgagactg ctgacgcccc agctcggctg      360

gaatactacg aaaatgccag gaagttccgg cacagtgtcc gcgccgcggc ggctgcagca      420

gcggcggccg cctctggcgc cgcgatcccc ccgctcattc caccgcggcg cgtgatcacc      480

ctataccagt gcttttccgt gagccagcga gcagatgcaa ggtaccgaca cctcattgct      540

cttttcaccc aagacgaata cttcgcgatg gtggccgaga acgagtcgga gcaggaaagc      600

tggtacttgc tgctcagccg cctcatcctc gagagcaagc gccgccgctg cggcacgctc      660

ggcgcgcagc cggacggaga gccggccgcg ctggcggcgg cagcggcggc ggagccaccc      720

ttctataaag atgtgtggca ggtaatagtc aaacccaggg ggctggggca cagaaaagag      780

ctgagcggcg tgttccggct gtgtctaacc gacgaggagg tcgtgtttgt gaggctgaac      840

accgaagtgg ccagcgtggt cgtccagctc ctgagcatcc gtcgctgtgg acactcggag      900

cagtatttct tcttggaagt aggcaggtcc actgtcatcg gtccgggaga gctctggatg      960

caggtcgatg actgtgtggt tgcccaaaac atgcatgagc tgtttttgga gaagatgaga     1020

gccttgtgtg cagacgaata cagagcccgc tgccgcagct acagcatcag catcggcgcc     1080

cacctgttaa ccctgctgtc cgctaggagg cacctgggct tggtgccgct cgagccggga     1140

ggctggctca gaaggtcccg ctttgagcag ttttgccacc tcagggccat cggcgacggg     1200

gaagacgaga tgcttttcac caggcgcttc gtaacaccca gcgagcctgt ggcccactcc     1260

aggcgaggaa gactgcacct gcccagaggg cgcaggtcaa ggagagcggt ttcagtgccg     1320

gccagctttt ttcgccgctt agcacccagc ccagcacgtc cccggcaccc tgcagaagcc     1380

ccgaacaatg gagctcgcct gtcttctgaa gtgtctggtt ctggctctgg caactttggg     1440

gaggaaggca atccccaggg caaagaagat caggaaggaa gcggaggtga ctacatgcct     1500

atgaacaatt ggggctcagg aaatggccgg ggctcaggag gtggccaggg ctcaaatggc     1560

caaggctcca gtagccatag ctcgggagga aaccagtgtt caggcgaggg acagggatcc     1620

cgaggtggtc agggctcaaa tggccagggc tcaggaggaa accagtgctc tagagatggc     1680

cagggcaccg caggtgggca cggttcaggt ggtggccaga gacctggagg tgggcatggc     1740

tcaggtggtg gccagggacc tggagatggc catggctcag gtggtggcaa gaactctggg     1800

gggggcaaag gctcaggaag tgggaaagga tccgatggtg atggtgaacg tggaaaatct     1860

ctgaagaaaa gatcctattt tggcaaatta actcaaagca agcaacagca aatgccacca     1920

cctccaccac ctcctcctcc acccccacca gctggaggaa ctggtggaaa agggaagtct     1980

gggggaagat tcagacttta tttttgtgtt gacagaggag ccacgaaaga atgcaaagaa     2040

gccaaagaag tgaaagatgc agagatccca gaaggtgcag ctcgaggtcc ccacagagcc     2100

agagcttttg atgaagatga ggatgaccca tacgtgccaa tgaggccagg ggtggccacc     2160

cctcttgtaa gctccagtga ttatatgcca atggctcctc aaaatgtctc tgcttcaaaa     2220

aagcgccact ctcgatcccc ttttgaagat tcaagagggt acatgatgat gtttcccaga     2280

gtgagcccac cacctgctcc gagtcctcca aaagcacctg atactaataa agaggatgac     2340

tcaaaggaca atgacagtga gagtgactac atgtttatgg ctcctggagc cggtgcaatt     2400

ccaaaaaacc ccagaaatcc tcagggtggc tcttcctcca aaagttggag ctcctacttc     2460

tctctaccaa acccttttcg gagctcacct ttgggacaga atgacaacag tgagtatgtg     2520

ccaatgttac ctggaaagtt cctggggagg ggcctagaca aagaagtctc ctataactgg     2580

gaccccaaag atgcagcttc aaagccttca ggtgagggat cattctcaaa gcctggagat     2640

gggggatcac cttcaaagcc ttcagatcat gagcccccaa agaataaagc taagagacct     2700

aaccgacttt cttttattac aaaaggatat aaaatcaagc caaaaccaca aaagcccaca     2760

catgagcaga gagaagctga cagctctagt gactacgtca acatggactt cactaaaaga     2820

gagagcaata caccagctcc ctctactcaa ggactaccag attcgtgggg cataattgct     2880

gaacccagac agtcagcctt ttctaattat gtgaatgttg agtttggagt gccatttcca     2940

aatccagcaa acgacctctc agatctttta agagctatac cacgtgccaa ccccttatct     3000

ctggacagtg ctaggtggcc acttcctccc cttcccctca gtgctacagg tagcaatgct     3060

attgaggaag agggtgacta cattgaagta attttcaact cagcaatgac accagccatg     3120

gctcttgctg acagtgccat tcgctatgat gctgaaacag gtcgaatcta tgtggtcgac     3180

ccattttctg agtgctgtat ggatatttct ctctccccca gccgatgttc tgaaccacca     3240

cctgtagcta ggctgctgca ggaagaagag caggagagaa gacgcccaca aagccgttct     3300

caaagtttct ttgcagcagc cagagccgct gtctctgctt ttccaacaga cagcctcgag     3360

agagaccttt ccccatcctc agccccggct gtcgcttcgg ctgcagagcc gactttagcc     3420

ctcagccaag ttgtagctgc ggcctccgcg ctcgccgcag ccccgggcat cggcgcagca     3480

gccgcagctg ctggatttga ctccgcctct gcccgctggt ttcaacctgt tgctaatgct     3540

gctgatgccg aagcagtaag gggagcccaa gacgttgccg gtggctcgaa ccctggagcc     3600

cacaacccat ctgcaaacct tgccagaggt gataaccagg ctggcggggc tgccgctgca     3660

gctgccgctc cggaaccacc acctcgcagt cgccgggtgc caagaccccc ggagagagaa     3720

gattctgaca acgacgacga cactcacgtg agaatggatt ttgccagacg tgataatcag     3780

ttcgactctc ccaaaagagg tcggtaattt tagaattaat ttccctaaag tgaatggtca     3840

ttgtctaatg attcgatgcg ctacagtcta cagtgttagg g                         3881


<210>  89
<211>  2844
<212>  DNA
<213>  Homo sapiens

<400>  89
gcgcaggcgc agacgactca ccctgggccg ggggtgaggc ttggactgtt tctttttcca       60

aaagaggagc tcaaaagaga aagttcatct agaaatctca aagccatgtc tcaggatgaa      120

ctagagtatg cccttacagg gatcagtgtc attcaaggat gtgactgtgg acttcaccca      180

ggaggagtgg cagcaactag accctgctca gaaggcgctt tacagggatg tgatgttgga      240

aaactattgc cacttcgtat ctgtggggtt tcacatggct aagcctgata tgatccgcaa      300

gttggaacaa ggagaagagc tatggacaca gagaattttt ccaagttaca gctacctaga      360

agaagatggg aaaactgaag atgtcttagt gaagttcaaa gaataccaag acaggcattc      420

tagacccctc atattcatca accacaaaaa actaattaag gagagaagta atatttatgg      480

taaaacattt actctaggca agaaccgtat ttcaaaaaca atactatgtg aatataaacc      540

tgatggaaaa gttttgaaaa atatttcaga actagtcatt agaaatataa gccccataaa      600

agagaagttt ggtgacagta ctggatggga gaaatcactc ctcaatacca agcatgagaa      660

aattcatcct gcagtgaatc tccataaaca aacagaaaga gttctcagtg gtaaacagga      720

gcttattcag catcagaagg ttcaagctcc agagcaacca tttgaccata atgaatgtga      780

aaaatccttc ctgatgaaag gaatgctatt tacacatact agagctcaca gaggagaaag      840

aacctttgaa tacaataaag atggaattgc cttcatagaa aagtcaagcc tcagtgtcca      900

tccaagtaat cttatggaaa agaagccctc tgcctacaac aaatatggga aattcctctg      960

cagaaagcct gtttttatta tgcctcagag acctcaaaca gaagagaaac cctttcactg     1020

tccttactgt gggaataact ttagaaggaa gtcatacctc attgaacatc agcgaattca     1080

cacaggtgaa aaaccttatg tttgcaatca atgtggaaag gccttccgtc agaagacagc     1140

cctcaccctt catgagaaaa cacatataga ggggaaaccc tttatttgta tcgattgtgg     1200

gaagtccttc cgccagaagg ccaccctcac tagacatcac aaaacacata cgggggagaa     1260

agcctatgaa tgtcctcagt gtggaagtgc ctttaggaag aagtcatacc tcattgatca     1320

ccagagaact cacacaggag agaaaccgta tcagtgtaat gagtgtggga aggcatttat     1380

ccagaagaca accctcactg ttcatcagag aactcacaca ggagagaaac cctatatttg     1440

caatgaatgt gggaagtcct tctgccaaaa gacaaccctc actctccacc agagaattca     1500

cacgggggaa aaaccctata tttgtaatga atgtgggaag tccttccgcc agaaggcaat     1560

cctcactgtt catcacagaa tacatacagg agaaaaatcc aatgggtgtc ctcagtgtgg     1620

gaaagccttc agtaggaaat caaacctcat tcgccatcag aaaactcaca caggcgagaa     1680

accatatgaa tgtaaacagt gtgggaagtt cttcagttgt aagtcaaacc tcattgtcca     1740

tcagaaaact cacaaggtag aaaccacggg aattcagtaa gtaatgtggc tttttttgta     1800

aaaaaatgtt aagtcatagt aaaccctgta gatgatgttg cttgcaagcg taatatccaa     1860

cagtttaagg tactatacca catggtaacc tactgtttgc cagcctgtaa aacacacaca     1920

cacacacaca cacacacaca aatattatta gacaaattag atgacaaaaa tcattaagaa     1980

gtccaaactt tttttttatt actagcttca gcagacaaaa acttcctctg tcaaggtgtt     2040

ataaacattt aaaatcacat tttccatttc catacatatc tttttgttca tcagtaataa     2100

ctagttggcc aactgactgt ggtccatgga ctacacagtg agtagaggtt ctttaaaaga     2160

aggaggtatg aactgtattt ctcattgcaa atacaaaata aaaattagtt gttacctcct     2220

cacagttgac catgattctg acttctaaca ttacaaatta gtttttacta ttataaacct     2280

ttctataaat tggattatat atcatgtatt ctttcatata cagcttatta ccttcatcat     2340

gtccgtgagt ctaatcatta gtacgtgtgg cagaagttta tttattttta tccagtatag     2400

aattcaatta tatgattata tcacaattta tccattctgc tgttgatgga cttttacatt     2460

gtttacagct tagggtcata ataaatcatg cttctgagaa catacttgtc ttggtgtaca     2520

tacatgtatt tctcttgtgt atatacttag gagtggaatc gctgggtctt agagcatgtg     2580

tgtattcagt cagatactgg cagacaattc agaactttca ccacatgaga taattgacac     2640

tgaagggaaa cagctataaa ttttatcaat atggtgctgg ttcaaaccag agaattcatg     2700

ctgcagggaa actcaatcaa tgttattgtg aaaactggga atgtgaatgt aatatatgta     2760

gaaaaacatt tagccacagc ccaaatcttc caggcaaatg taataaacgt gacattgccg     2820

ttagccaaaa aaaaaaaaaa aaaa                                            2844


<210>  90
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  90
aggcgcagtt actgatatag ccaaggtggg acactactgg agggagctag aagggatcag       60

ccagccatgc ctccagttca ggtacttggc attgctaagc tcagaacagg acttgccagt      120

gtctagatga aaaagaggag agatctcaag agggataacc aattggctgg caaagtaaca      180

aatgaaaagt aacctgactc tattgacctg cttaaccctg catggggggg aaggatggaa      240

aggagcagct gtttgctttg aaacggtgga acagttttgc agccttagaa aatggcatgt      300

aacataccta accaaagaca gcggactctg tcaacaacag gagaagctct atacgaaatt      360

cttggtctgc ataagggagc atcaaatgaa gaaattaaga aaacctacag aaaattggcc      420

ctgaaacacc atccagacaa gaatccagat gatccagctg ctactgagaa gtttaaagaa      480

atcaacaacg cccacgcaat acttaccgac atttcaaaga gaagcatata cgacaagtac      540

ggatcgctgg gactctacgt ggccgagcag tttggagacg aaaacgttaa cacctacttc      600

atgctgtcga gctggtgggc aaaggccctg tttgtcatcg ttggcctctt gacgggctgc      660

tacttttgct gctgcctgtg ctgctgctgc aactgctgct gtggacactg ccggcccgag      720

tcatcagtgc cagaagagga cttctatgtg tccccagagg atctggagga gcagatcaag      780

tctgacatgg aaaaagatgt ggactttcca gtttttctcc agcctacaaa tgcaaatgag      840

aaaacacagc taatcaaaga aggatctcga agttattgca cagactcttg atattgagcc      900

ctcagagagt ccacagtccc tcctctcagt tcagtcttgt ctccagatgg tcgtagggga      960

gcgtgtgggg cataaagtgc tgtgaacttt tccatcttgt tgttttattt ttgggttagg     1020

aaaacatgat tgctatataa ttttctcagt atgcagactt tctctctgag tagaatttct     1080

tatgaaacac attcaatttg ggtgaataaa ggcctgaaga gttattttac cctccttgcc     1140

tgatgtagga cagtggaatt gtacagcctt tatgaacctg ccctttatgt gtggcagatc     1200

tgattcctaa ctgaccaaag taatattcca gaacaaaagc cacttttctt acatttaaca     1260

caatattcat atctaccacg aacatgatca tcaaaatata tgagaactta taaagagttt     1320

ttgtgtgtgg agcctcttcc gtgtcaatat tcaataaagt tatagaaatg tttcaagagc     1380

aaaaaaaaaa aaaaaaaa                                                   1398


<210>  91
<211>  2244
<212>  DNA
<213>  Homo sapiens

<400>  91
gctctgagtc atagggaagc catcccagaa gccaggtcta ctcatcaata agcagctgcc       60

tgtgcagagt gcaggctgca cctttggaca gcctttaaaa ctgaattctc agaattttag      120

aacaaatttt tgtctagaaa tgctgacttt ggttcattag gtagtggtaa aacaggctcc      180

cttcgaagct ctccttcatc accttcctaa gtgcatgggg gaaaatacct agggctcaac      240

agtcttgaga agtgtggaaa cattttcttt gtgagtgaga acagatcacc tagagaaagg      300

agaccagatt cccatcactg cttctgggta tcagatgcta gcgctgcact ccattttgca      360

atggcctccc ttgctgcagc aaatgcagag ttttgcttca acctgttcag agagatggat      420

gacaatcaag gaaatggaaa tgtgttcttt tcctctctga gcctcttcgc tgccctggcc      480

ctggtccgct tgggcgctca agatgactcc ctctctcaga ttgataagtt gcttcatgtt      540

aacactgcct caggatatgg aaactcttct aatagtcagt cagggctcca gtctcaactg      600

aaaagagttt tttctgatat aaatgcatcc cacaaggatt atgatctcag cattgtgaat      660

gggctttttg ctgaaaaagt gtatggcttt cataaggact acattgagtg tgccgaaaaa      720

ttatacgatg ccaaagtgga gcgagttgac tttacgaatc atttagaaga cactagacgt      780

aatattaata agtgggttga aaatgaaaca catggcaaaa tcaagaacgt gattggtgaa      840

ggtggcataa gctcatctgc tgtaatggtg ctggtgaatg ctgtgtactt caaaggcaag      900

tggcaatcag ccttcaccaa gagcgaaacc ataaattgcc atttcaaatc tcccaagtgc      960

tctgggaagg cagtcgccat gatgcatcag gaacggaagt tcaatttgtc tgttattgag     1020

gacccatcaa tgaagattct tgagctcaga tacaatggtg gcataaacat gtacgttctg     1080

ctgcctgaga atgacctctc tgaaattgaa aacaaactga cctttcagaa tctaatggaa     1140

tggaccaatc caaggcgaat gacctctaag tatgttgagg tattttttcc tcagttcaag     1200

atagagaaga attatgaaat gaaacaatat ttgagagccc tagggctgaa agatatcttt     1260

gatgaatcca aagcagatct ctctgggatt gcttcggggg gtcgtctgta tatatcaagg     1320

atgatgcaca aatcttacat agaggtcact gaggagggca ccgaggctac tgctgccaca     1380

ggaagtaata ttgtagaaaa gcaactccct cagtccacgc tgtttagagc tgaccaccca     1440

ttcctatttg ttatcaggaa ggatgacatc atcttattca gtggcaaagt ttcttgccct     1500

tgaaaatcca attggtttct gttatagcag tccccacaac atcaaagaac caccacaagt     1560

caatagattt gagtttaatt ggaaaaatgt ggtgtttcct ttgagtttat ttcttcctaa     1620

cattggtcag cagatgacac tggtgacttg acccttccta gacacctggt tgattgtcct     1680

gatccctgct cttagcattc taccaccatg tgtctcaccc atttctaatt tcattgtctt     1740

tcttcccacg ctcatttcta tcattctccc ccatgacccg tctggaaatt atggagagtg     1800

ctcaactggt aaggagaacg tagaagtagc cctagggatc ctttttgaaa ctctacagtt     1860

atcgcagata ttctagcttc attgtaagca atctaggaaa taagccctgc tgctttctag     1920

aaataagtgt gaaggataaa ttttctttgt tgacctatga agattttaga gtttaccttc     1980

atatgtttga ttttaaatca gtgtataatc tagatggtaa aaaatgtgaa attgggatta     2040

gggaccaacc aaaatatttc attaatgctt tcaattgaca aattttggtc tttctttgat     2100

aagacaatat gtacatagtt ttttcaaata ttaaagatct tttaactgtt ggcagttgtt     2160

atctacagaa tcatatctca tatgctgtgt agtttataag ttttttctct atttatcaga     2220

ataaagaaat acaacatacc tgta                                            2244


<210>  92
<211>  1784
<212>  DNA
<213>  Homo sapiens

<400>  92
cgggattacc gagggggtgc gggatgctga tgctgaactg gccaagctgg gagggaagaa       60

gaaagggagg ggaggggaga atcgaggacg gacggcctag ccaggccaag aatgcaattg      120

ccccggtggt gggagctggg agacccctgt gcttggacgg gacagggtcg ggggacacgc      180

aggatgagcc ccgcgaccac tggcacattc ttgctgacag tgtacagtat tttctccaag      240

gtacactccg atcggaatgt atacccatca gcaggtgtcc tctttgttca tgttttggaa      300

agagaatatt ttaaggggga atttccacct tacccaaaac ctggcgagat tagtaatgat      360

cccataacat ttaatacaaa tttaatgggt tacccagacc gacctggatg gcttcgatat      420

atccaaagga caccatatag tgatggagtc ctatatgggt ccccaacagc tgaaaatgtg      480

gggaagccaa caatcattga gataactgcc tacaacaggc gcacctttga gactgcaagg      540

cataatttga taattaatat aatgtctgca gaagacttcc cgttgccata tcaagcagaa      600

ttcttcatta agaatatgaa tgtagaagaa atgttggcca gtgaggttct tggagacttt      660

cttggcgcag tgaaaaatgt gtggcagcca gagcgcctga acgccataaa catcacatcg      720

gccctagaca ggggtggcag ggtgccactt cccattaatg acctgaagga gggcgtttat      780

gtcatggttg gtgcagatgt cccgttttct tcttgtttac gagaagttga aaatccacag      840

aatcaattga gatgtagtca agaaatggag cctgtaataa catgtgataa aaaatttcgt      900

actcaatttt acattgactg gtgcaaaatt tcattggttg ataaaacaaa gcaagtgtcc      960

acctatcagg aagtgattcg tggagagggg attttacctg atggtggaga atacaaaccc     1020

ccttctgatt ctttgaaaag cagagactat tacacggatt tcctaattac actggctgtg     1080

ccctcggcag tggcactggt cctttttcta atacttgctt atatcatgtg ctgccgacgg     1140

gaaggcgtgg aaaagagaaa catgcaaaca ccagacatcc aactggtcca tcacagtgct     1200

attcagaaat ctaccaagga gcttcgagac atgtccaaga atagagagat agcatggccc     1260

ctgtcaacgc ttcctgtgtt ccaccctgtg actggggaaa tcatacctcc tttacacaca     1320

gacaactatg atagcacaaa catgccattg atgcaaacgc agcaatggag tttcgctcct     1380

gttgcccagg ctggagtgca atggagcgat cttggctcac tgcagcctcc gcctcccagg     1440

aacttgccac atcagactca gattccccaa cagcagacta caggtaaatg gtatccctga     1500

agaaagaaaa ctgactgaag caatgaattt ataatcagac aatatagcag ttacatcaca     1560

tttcttttct cttccaataa tgcatgagct tttctggcat atgttatgca tgttggcagt     1620

attaagtgta taccaaataa tacaacataa ctttcatttt actaatgtat ttttttgtac     1680

ttaaagcatt tttgacaatt tgtaaaacat tgatgacttt atatttgtta caataaaagt     1740

tgatctttaa aataaatatt attaatgaag cctaaaaaaa aaaa                      1784


<210>  93
<211>  2147
<212>  DNA
<213>  Homo sapiens

<400>  93
gatttgtaag tttacctgtt gcagccaata gcagggccat ctcagccagc cagcactgga       60

tactatctgg ccagaagtag caaagcagct cttatttgaa aaaccactgg gttccgagtt      120

cattactaca ggaaaaactg ttctcttctg tggcacagag aaccctgctt caaagcagaa      180

gtagcagttc cggagtccag ctggctaaaa ctcatcccag aggataatgg caacccatgc      240

cttagaaatc gctgggctgt ttcttggtgg tgttggaatg gtgggcacag tggctgtcac      300

tgtcatgcct cagtggagag tgtcggcctt cattgaaaac aacatcgtgg tttttgaaaa      360

cttctgggaa ggactgtgga tgaattgcgt gaggcaggct aacatcagga tgcagtgcaa      420

aatctatgat tccctgctgg ctctttctcc ggacctacag gcagccagag gactgatgtg      480

tgctgcttcc gtgatgtcct tcttggcttt catgatggcc atccttggca tgaaatgcac      540

caggtgcacg ggggacaatg agaaggtgaa ggctcacatt ctgctgacgg ctggaatcat      600

cttcatcatc acgggcatgg tggtgctcat ccctgtgagc tgggttgcca atgccatcat      660

cagagatttc tataactcaa tagtgaatgt tgcccaaaaa cgtgagcttg gagaagctct      720

ctacttagga tggaccacgg cactggtgct gattgttgga ggagctctgt tctgctgcgt      780

tttttgttgc aacgaaaaga gcagtagcta cagatactcg ataccttccc atcgcacaac      840

ccaaaaaagt tatcacaccg gaaagaagtc accgagcgtc tactccagaa gtcagtatgt      900

gtagttgtgt atgttttttt aactttacta taaagccatg caaatgacaa aaatctatat      960

tactttctca aaatggaccc caaagaaact ttgatttact gttcttaact gcctaatctt     1020

aattacagga actgtgcatc agctatttat gattctataa gctatttcag cagaatgaga     1080

tattaaaccc aatgctttga ttgttctaga aagtatagta atttgttttc taaggtggtt     1140

caagcatcta ctctttttat catttacttc aaaatgacat tgctaaagac tgcattattt     1200

tactactgta atttctccac gacatagcat tatgtacata gatgagtgta acatttatat     1260

ctcacataga gacatgctta tatggtttta tttaaaatga aatgccagtc cattacactg     1320

aataaataga actcaactat tgcttttcag ggaaatcatg gatagggttg aagaaggtta     1380

ctattaattg tttaaaaaca gcttagggat taatgtcctc catttataat gaagattaaa     1440

atgaaggctt taatcagcat tgtaaaggaa attgaatggc tttctgatat gctgtttttt     1500

agcctaggag ttagaaatcc taacttcttt atcctcttct cccagaggct ttttttttct     1560

tgtgtattaa attaacattt ttaaaaagca gatattttgt caaggggctt tgcattcaaa     1620

ctgcttttcc agggctatac tcagaagaaa gataaaagtg tgatctaaga aaaagtgatg     1680

gttttaggaa agtgaaaata tttttgtttt tgtatttgaa gaagaatgat gcattttgac     1740

aagaaatcat atatgtatgg atatatttta ataagtattt gagtacagac tttgaggttt     1800

catcaatata aataaaagag cagaaaaata tgtcttggtt ttcatttgct taccaaaaaa     1860

acaacaacaa aaaaagttgt cctttgagaa cttcacctgc tcctatgtgg gtacctgagt     1920

caaaattgtc atttttgttc tgtgaaaaat aaatttcctt cttgtaccat ttctgtttag     1980

ttttactaaa atctgtaaat actgtatttt tctgtttatt ccaaatttga tgaaactgac     2040

aatccaattt gaaagtttgt gtcgacgtct gtctagctta aatgaatgtg ttctatttgc     2100

tttatacatt tatattaata aattgtacat ttttctaatt atttgaa                   2147


<210>  94
<211>  2240
<212>  DNA
<213>  Homo sapiens

<400>  94
gagtcagagc ctcttctctc taagtcacgg gaactgccct tgctacttgt gacctgccct       60

ttactcagca gtttttgttc tgggaagccc tgggattctg ctaataccta tcactgtagg      120

tgctgaaggg aaacagatga agaacatgac ctcaaggagc ttcctgtcaa tgagaagacc      180

aagctgacgc ctggcaaaga tattaaagag gagcctgaaa ctgttccttg gacatcttat      240

gaatgtcaga aaataccttt tggagggtta gaagatcagg ggacatggtt gttcacattt      300

gctgccacgg aacaccgcca gtcttcactt ggaaacagaa tcacgccttg tgaagagatc      360

atccctaagc aggagagaag ctactaaagg attgtgtcct cctccacctt ccctgtgctc      420

ggtctccacc tgtctcccat tctgtgacga tggttcaatg gaagagactc tgccagctgc      480

attacttgtg ggctctgggc tgctatatgc tgctggccac tgtggctctg aaactttctt      540

tcaggttgaa gtgtgactct gaccacttgg gtctggagtc cagggaatct caaagccagt      600

actgtaggaa tatcttgtat aatttcctga aacttccagc aaagaggtct atcaactgtt      660

caggggtcac ccgaggggac caagaggcag tgcttcaggc tattctgaat aacctggagg      720

tcaagaagaa gcgagagcct ttcacagaca cccactacct ctccctcacc agagactgtg      780

agcacttcaa ggctgaaagg aagttcatac agttcccact gagcaaagaa gaggtggagt      840

tccctattgc atactctatg gtgattcatg agaagattga aaactttgaa aggctactgc      900

gagctgtgta tgcccctcag aacatatact gtgtccatgt ggatgagaag tccccagaaa      960

ctttcaaaga ggcggtcaaa gcaattattt cttgcttccc aaatgtcttc atagccagta     1020

agctggttcg ggtggtttat gcctcctggt ccagggtgca agctgacctc aactgcatgg     1080

aagacttgct ccagagctca gtgccgtgga aatacttcct gaatacatgt gggacggact     1140

ttcctataaa gagcaatgca gagatggtcc aggctctcaa gatgttgaat gggaggaata     1200

gcatggagtc agaggtacct cctaagcaca aagaaacccg ctggaaatat cactttgagg     1260

tagtgagaga cacattacac ctaaccaaca agaagaagga tcctccccct tataatttaa     1320

ctatgtttac agggaatgcg tacattgtgg cttcccgaga tttcgtccaa catgttttga     1380

agaaccctaa atcccaacaa ctgattgaat gggtaaaaga cacttatagc ccagatgaac     1440

acctctgggc cacccttcag cgtgcacggt ggatgcctgg ctctgttccc aaccacccca     1500

agtacgacat ctcagacatg acttctattg ccaggctggt caagtggcag ggtcatgagg     1560

gagacatcga taagggtgct ccttatgctc cctgctctgg aatccaccag cgggctatct     1620

gcgtttatgg ggctggggac ttgaattgga tgcttcaaaa ccatcacctg ttggccaaca     1680

agtttgaccc aaaggtagat gataatgctc ttcagtgctt agaagaatac ctacgttata     1740

aggccatcta tgggactgaa ctttgagaca cactatgaga gcgttgctac ctgtggggca     1800

agagcatgta caaacatgct cagaacttgc tgggacagtg tgggtgggag accagggctt     1860

tgcaattcgt ggcatccttt aggataagag ggctgctatt agagtgtggg taagtagatc     1920

ttttgccttg caaattgctg cctgggtgaa tgctgcttgt tctctcaccc ctaaccctag     1980

tagttcctcc actaactttc tcactaagtg agaatgagaa ctgctgtgat agggagagtg     2040

aaggagggat atgtggtaga gcacttgatt tcagttgaat gcctgctggt agcttttcca     2100

ttctgtggag ctgccgttcc taataattcc aggtttggta gcgtggagga gaactttgat     2160

ggaaagagaa ccttcccttc tgtactgtta acttaaaaat aaatagctcc tgattcaaag     2220

taaaaaaaaa aaaaaaaaaa                                                 2240


<210>  95
<211>  4950
<212>  DNA
<213>  Homo sapiens

<400>  95
cagagcaggg tggagagggc ggtgggaggc gtgtgcctga gtgggctcta ctgccttgtt       60

ccatattatt ttgtgcacat tttccctggc actctgggtt gctagccccg ccgggcactg      120

ggcctcagac actgcgcggt tccctcggag cagcaagcta aagaaagccc ccagtgccgg      180

cgaggaagga ggcggcgggg aaagatgcgc ggcgttggct ggcagatgct gtccctgtcg      240

ctggggttag tgctggcgat cctgaacaag gtggcaccgc aggcgtgccc ggcgcagtgc      300

tcttgctcgg gcagcacagt ggactgtcac gggctggcgc tgcgcagcgt gcccaggaat      360

atcccccgca acaccgagag actggattta aatggaaata acatcacaag aattacgaag      420

acagattttg ctggtcttag acatctaaga gttcttcagc ttatggagaa taagattagc      480

accattgaaa gaggagcatt ccaggatctt aaagaactag agagactgcg tttaaacaga      540

aatcaccttc agctgtttcc tgagttgctg tttcttggga ctgcgaagct atacaggctt      600

gatctcagtg aaaaccaaat tcaggcaatc ccaaggaaag ctttccgtgg ggcagttgac      660

ataaaaaatt tgcaactgga ttacaaccag atcagctgta ttgaagatgg ggcattcagg      720

gctctccggg acctggaagt gctcactctc aacaataaca acattactag actttctgtg      780

gcaagtttca accatatgcc taaacttagg acttttcgac tgcattcaaa caacctgtat      840

tgtgactgcc acctggcctg gctctccgac tggcttcgcc aaaggcctcg ggttggtctg      900

tacactcagt gtatgggccc ctcccacctg agaggccata atgtagccga ggttcaaaaa      960

cgagaatttg tctgcagtgg tcaccagtca tttatggctc cttcttgtag tgttttgcac     1020

tgccctgccg cctgtacctg tagcaacaat atcgtagact gtcgtgggaa aggtctcact     1080

gagatcccca caaatcttcc agagaccatc acagaaatac gtttggaaca gaacacaatc     1140

aaagtcatcc ctcctggagc tttctcacca tataaaaagc ttagacgaat tgacctgagc     1200

aataatcaga tctctgaact tgcaccagat gctttccaag gactacgctc tctgaattca     1260

cttgtcctct atggaaataa aatcacagaa ctccccaaaa gtttatttga aggactgttt     1320

tccttacagc tcctattatt gaatgccaac aagataaact gccttcgggt agatgctttt     1380

caggatctcc acaacttgaa ccttctctcc ctatatgaca acaagcttca gaccatcgcc     1440

aaggggacct tttcacctct tcgggccatt caaactatgc atttggccca gaaccccttt     1500

atttgtgact gccatctcaa gtggctagcg gattatctcc ataccaaccc gattgagacc     1560

agtggtgccc gttgcaccag cccccgccgc ctggcaaaca aaagaattgg acagatcaaa     1620

agcaagaaat tccgttgttc agctaaagaa cagtatttca ttccaggtac agaagattat     1680

cgatcaaaat taagtggaga ctgctttgcg gatctggctt gccctgaaaa gtgtcgctgt     1740

gaaggaacca cagtagattg ctctaatcaa aagctcaaca aaatcccgga gcacattccc     1800

cagtacactg cagagttgcg tctcaataat aatgaattta ccgtgttgga agccacagga     1860

atctttaaga aacttcctca attacgtaaa ataaacttta gcaacaataa gatcacagat     1920

attgaggagg gagcatttga aggagcatct ggtgtaaatg aaatacttct tacgagtaat     1980

cgtttggaaa atgtgcagca taagatgttc aagggattgg aaagcctcaa aactttgatg     2040

ttgagaagca atcgaataac ctgtgtgggg aatgacagtt tcataggact cagttctgtg     2100

cgtttgcttt ctttgtatga taatcaaatt actacagttg caccaggggc atttgatact     2160

ctccattctt tatctactct aaacctcttg gccaatcctt ttaactgtaa ctgctacctg     2220

gcttggttgg gagagtggct gagaaagaag agaattgtca cgggaaatcc tagatgtcaa     2280

aaaccatact tcctgaaaga aatacccatc caggatgtgg ccattcagga cttcacttgt     2340

gatgacggaa atgatgacaa tagttgctcc ccactttctc gctgtcctac tgaatgtact     2400

tgcttggata cagtcgtccg atgtagcaac aagggtttga aggtcttgcc gaaaggtatt     2460

ccaagagatg tcacagagtt gtatctggat ggaaaccaat ttacactggt tcccaaggaa     2520

ctctccaact acaaacattt aacacttata gacttaagta acaacagaat aagcacgctt     2580

tctaatcaga gcttcagcaa catgacccag ctcctcacct taattcttag ttacaaccgt     2640

ctgagatgta ttcctcctcg cacctttgat ggattaaagt ctcttcgatt actttctcta     2700

catggaaatg acatttctgt tgtgcctgaa ggtgctttca atgatctttc tgcattatca     2760

catctagcaa ttggagccaa ccctctttac tgtgattgta acatgcagtg gttatccgac     2820

tgggtgaagt cggaatataa ggagcctgga attgctcgtt gtgctggtcc tggagaaatg     2880

gcagataaac ttttactcac aactccctcc aaaaaattta cctgtcaagg tcctgtggat     2940

gtcaatattc tagctaagtg taacccctgc ctatcaaatc cgtgtaaaaa tgatggcaca     3000

tgtaatagtg atccagttga cttttaccga tgcacctgtc catatggttt caaggggcag     3060

gactgtgatg tcccaattca tgcctgcatc agtaacccat gtaaacatgg aggaacttgc     3120

cacttaaagg aaggagaaga agatggattc tggtgtattt gtgctgatgg atttgaagga     3180

gaaaattgtg aagtcaacgt tgatgattgt gaagataatg actgtgaaaa taattctaca     3240

tgtgtcgatg gcattaataa ctacacatgc ctttgcccac ctgagtatac aggtgagttg     3300

tgtgaggaga agctggactt ctgtgcccag gacctgaacc cctgccagca cgattcaaag     3360

tgcatcctaa ctccaaaggg attcaaatgt gactgcacac cagggtacgt aggtgaacac     3420

tgcgacatcg attttgacga ctgccaagac aacaagtgta aaaacggagc ccactgcaca     3480

gatgcagtga acggctatac gtgcatatgc cccgaaggtt acagtggctt gttctgtgag     3540

ttttctccac ccatggtcct ccctcgtacc agcccctgtg ataattttga ttgtcagaat     3600

ggagctcagt gtatcgtcag aataaatgag ccaatatgtc agtgtttgcc tggctatcag     3660

ggagaaaagt gtgaaaaatt ggttagtgtg aattttataa acaaagagtc ttatcttcag     3720

attccttcag ccaaggttcg gcctcagacg aacataacac ttcagattgc cacagatgaa     3780

gacagcggaa tcctcctgta taagggtgac aaagaccata tcgcggtaga actctatcgg     3840

gggcgtgttc gtgccagcta tgacaccggc tctcatccag cttctgccat ttacagtgtg     3900

gagacaatca atgatggaaa cttccacatt gtggaactac ttgccttgga tcagagtctc     3960

tctttgtccg tggatggtgg gaaccccaaa atcatcacta acttgtcaaa gcagtccact     4020

ctgaattttg actctccact ctatgtagga ggcatgccag ggaagagtaa cgtggcatct     4080

ctgcgccagg cccctgggca gaacggaacc agcttccacg gctgcatccg gaacctttac     4140

atcaacagtg agctgcagga cttccagaag gtgccgatgc aaacaggcat tttgcctggc     4200

tgtgagccat gccacaagaa ggtgtgtgcc catggcacat gccagcccag cagccaggca     4260

ggcttcacct gcgagtgcca ggaaggatgg atggggcccc tctgtgacca acggaccaat     4320

gacccttgcc ttggaaataa atgcgtacat ggcacctgct tgcccatcaa tgcgttctcc     4380

tacagctgta agtgcttgga gggccatgga ggtgtcctct gtgatgaaga ggaggatctg     4440

tttaacccat gccaggcgat caagtgcaag cacgggaagt gcaggctttc aggtctgggg     4500

cagccctact gtgaatgcag cagtggatac acgggggaca gctgtgatcg agaaatctct     4560

tgtcgagggg aaaggataag agattattac caaaagcagc agggctatgc tgcttgccaa     4620

acaaccaaga aggtgtcccg attagagtgc agaggtgggt gtgcaggagg gcagtgctgt     4680

ggaccgctga ggagcaagcg gcggaaatac tctttcgaat gcactgacgg ctcctccttt     4740

gtggacgagg ttgagaaagt ggtgaagtgc ggctgtacga ggtgtgtgtc ctaaacacac     4800

tcccggcagc tctgtctttg gaaaaggttg tatacttctt gaccatgtgg gactaatgaa     4860

tgcttcatag tggaaatatt tgaaatatat tgtaaaatac agaacagact tatttttatt     4920

atgagaataa agactttttt tctgcatttg                                      4950


<210>  96
<211>  2800
<212>  DNA
<213>  Homo sapiens

<400>  96
atttgagtgg gaatctcaaa gcagttgagt aggcagaaaa aagaacctct tcattaagga       60

ttaaaatgta taggccagca cgtgtaactt cgacttcaag atttctgaat ccatatgtag      120

tatgtttcat tgtcgtcgca ggggtagtga tcctggcagt caccatagct ctacttgttt      180

actttttagc ttttgatcaa aaatcttact tttataggag cagttttcaa ctcctaaatg      240

ttgaatataa tagtcagtta aattcaccag ctacacagga atacaggact ttgagtggaa      300

gaattgaatc tctgattact aaaacattca aagaatcaaa tttaagaaat cagttcatca      360

gagctcatgt tgccaaactg aggcaagatg gtagtggtgt gagagcggat gttgtcatga      420

aatttcaatt cactagaaat aacaatggag catcaatgaa aagcagaatt gagtctgttt      480

tacgacaaat gctgaataac tctggaaacc tggaaataaa cccttcaact gagataacat      540

cacttactga ccaggctgca gcaaattggc ttattaatga atgtggggcc ggtccagacc      600

taataacatt gtctgagcag agaatccttg gaggcactga ggctgaggag ggaagctggc      660

cgtggcaagt cagtctgcgg ctcaataatg cccaccactg tggaggcagc ctgatcaata      720

acatgtggat cctgacagca gctcactgct tcagaagcaa ctctaatcct cgtgactgga      780

ttgccacgtc tggtatttcc acaacatttc ctaaactaag aatgagagta agaaatattt      840

taattcataa caattataaa tctgcaactc atgaaaatga cattgcactt gtgagacttg      900

agaacagtgt cacctttacc aaagatatcc atagtgtgtg tctcccagct gctacccaga      960

atattccacc tggctctact gcttatgtaa caggatgggg cgctcaagaa tatgctggcc     1020

acacagttcc agagctaagg caaggacagg tcagaataat aagtaatgat gtatgtaatg     1080

caccacatag ttataatgga gccatcttgt ctggaatgct gtgtgctgga gtacctcaag     1140

gtggagtgga cgcatgtcag ggtgactctg gtggcccact agtacaagaa gactcacggc     1200

ggctttggtt tattgtgggg atagtaagct ggggagatca gtgtggcctg ccggataagc     1260

caggagtgta tactcgagtg acagcctacc ttgactggat taggcaacaa actgggatct     1320

agtgcaacaa gtgcatccct gttgcaaagt ctgtatgcag gtgtgcctgt cttaaattcc     1380

aaagctttac atttcaactg aaaaagaaac tagaaatgtc ctaatttaac atcttgttac     1440

ataaatatgg tttaacaaac actgtttaac ctttctttat tattaaaggt tttctatttt     1500

ctccagagaa ctatatgaat gttgcatagt actgtggctg tgtaacagaa gaaacacact     1560

aaactaatta caaagttaac aatttcatta cagttgtgct aaatgcccgt agtgagaaga     1620

acaggaacct tgagcatgta tagtagagga acctgcacag gtctgatggg tcagaggggt     1680

cttctctggg tttcactgag gatgagaagt aagcaaactg tggaaacatg caaaggaaaa     1740

agtgatagaa taatattcaa gacaaaaaga acagtatgag gcaagagaaa taatatgtat     1800

ttaaaatttt tggttactca atatcttata cttagtatga gtcctaaaat taaaaatgtg     1860

aaactgttgt actatacgta taacctaacc ttaattattc tgtaagaaca tgcttccata     1920

ggaaatagtg gataattttc agctatttaa ggcaaaagct aaaatagttc actcctcaac     1980

tgagacccaa agaattatag atatttttca tgatgaccca tgaaaaatat cactcatcta     2040

cataaaggag agactatatc tattttatag agaagctaag aaatatacct acacaaactt     2100

gtcaggtgct ttacaactac atagtacttt ttaacaacaa aataataatt ttaagaatga     2160

aaaatttaat catcgggaag aacgtcccac tacagacttc ctatcactgg cagttatatt     2220

tttgagcgta aaagggtcgt caaacgctaa atctaagtaa cgaattgaaa gtttaaagag     2280

ggggaagagt tggtttgcaa aggaaaagtt taaatagctt aatatcaata gaatgatcct     2340

gaagacagaa aaaactttgt cactcttcct ctctcatttt ctttctctct ctctcccctt     2400

ctcatacaca tgcctccccc accaaagaat ataatgtaaa ttaaatccac taaaatgtaa     2460

tggcatgaaa atctctgtag tctgaatcac taatattcct gagtttttat gagctcctag     2520

tacagctaaa gtttgcctat gcatgatcat ctatgcgtca gagcttcctc cttctacaag     2580

ctaactccct gcatctgggc atcaggactg ctccatacat ttgctgaaaa cttcttgtat     2640

ttcctgatgt aaaattgtgc aaacacctac aataaagcca tctactttta gggaaaggga     2700

gttgaaaatg caaccaactc ttggcgaact gtacaaacaa atctttgcta tactttattt     2760

caaataaatt ctttttaaaa taaaaaaaaa aaaaaaaaaa                           2800


<210>  97
<211>  6629
<212>  DNA
<213>  Homo sapiens

<400>  97
ctagaaacag caagtacgct gctcaaccct gcctgaactt tcctgtaaac agccactgac       60

agactgcatc cctgctgggt ggatcctgcg actcctagag ggaatggcac ttcttgtttt      120

taattagcaa ggtgaaaggt gaattaaaac tagcagtttg gcaagtcagt gcaagaggct      180

gacttctgag aggcttccag gagcccgaag agaggacctc cacgggagaa gggagtgcgt      240

gtgctcggtt ttgttttttt ctctcttttt tttttttttt tctgaatgaa cagctttgcc      300

caagtgactg aaaaatacag cttcttcctg aatctaccgg cgtagttgct gaagagcgct      360

ctagacagga catggctctg aagactcact ctttggaatg tcctcttgct cccggcttat      420

aaacaactgt cccgaggaaa gaaaggtttt acatagccaa atacagcctg acaaatggca      480

cttcggaact gtgctttctg atgacaacgc gttcgatttc tgacaaagcc tctcgcacgc      540

tgcccctgga gggaagtcct aagtaaaact cagaccctcc ttaaagtgag gagcgagggc      600

ttggacggtg aacacggcag catggcatcc gcggggcaca ttatcacctt gctcctgtgg      660

ggttacttac tggagctttg gacaggaggt catacagctg atactaccca cccccggtta      720

cgcctgtcac ataaagagct cttgaatctg aacagaacat caatatttca tagccctttt      780

ggatttcttg atctccatac aatgctgctg gatgaatatc aagagaggct cttcgtggga      840

ggcagggacc ttgtatattc cctcagcttg gagagaatca gtgacggcta taaagagata      900

cactggccga gtacagctct aaaaatggaa gaatgcataa tgaagggaaa agatgcgggt      960

gaatgtgcaa attatgttcg ggttttgcat cactataaca ggacacacct tctgacctgt     1020

ggtactggag cttttgatcc agtttgtgcc ttcatcagag ttggatatca tttggaggat     1080

cctctgtttc acctggaatc acccagatct gagagaggaa ggggcagatg tccttttgac     1140

cccagctcct ccttcatctc cactttaatt ggtagtgaat tgtttgctgg actctacagt     1200

gactactgga gcagagacgc tgcgatcttc cgcagcatgg ggcgactggc ccatatccgc     1260

actgagcatg acgatgagcg tctgttgaaa gaaccaaaat ttgtaggttc atacatgatt     1320

cctgacaatg aagacagaga tgacaacaaa gtatatttct tttttactga gaaggcactg     1380

gaggcagaaa acaatgctca cgcaatttac accagggtcg ggcgactctg tgtgaatgat     1440

gtaggagggc agagaatact ggtgaataag tggagcactt tcctaaaagc gagactcgtt     1500

tgctcagtac caggaatgaa tggaattgac acatattttg atgaattaga ggacgttttt     1560

ttgctaccta ccagagatca taagaatcca gtgatatttg gactctttaa cactaccagt     1620

aatatttttc gagggcatgc tatatgtgtc tatcacatgt ctagcattcg ggcagccttc     1680

aacggaccat atgcacataa ggaaggacct gaataccact ggtcagtcta tgaaggaaaa     1740

gtcccttatc caaggcctgg ttcttgtgcc agcaaagtaa atggagggag atacggaacc     1800

accaaggact atcctgatga tgccatccga tttgcaagaa gtcatccact aatgtaccag     1860

gccataaaac ctgcccataa aaaaccaata ttggtaaaaa cagatggaaa atataacctg     1920

aaacaaatag cagtagatcg agtggaagct gaggatggcc aatatgacgt cttgtttatt     1980

gggacagata atggaattgt gctgaaagta atcacaattt acaaccaaga aatggaatca     2040

atggaagaag taattctaga agaacttcag atattcaagg atccagttcc tattatttct     2100

atggagattt cttcaaagcg gcaacagctg tatattggat ctgcttctgc tgtggctcaa     2160

gtcagattcc atcactgtga catgtatgga agtgcttgtg ctgactgctg cctggctcga     2220

gacccttact gtgcctggga tggcatatcc tgctcccggt attacccaac aggcacacat     2280

gcaaaaaggc gtttccggag acaagatgtt cgacatggaa atgcagctca gcagtgcttt     2340

ggacaacagt ttgttgggga tgctttggat aagactgaag aacatctggc ttatggcata     2400

gagaacaaca gtactttgct ggaatgtacc ccacgatctt tacaagcgaa agttatctgg     2460

tttgtacaga aaggacgtga gacaagaaaa gaggaggtga agacagatga cagagtggtt     2520

aagatggacc ttggtttact cttcctaagg ttacacaaat cagatgctgg gacctatttt     2580

tgccagacag tagagcatag ctttgtccat acggtccgta aaatcacctt ggaggtagtg     2640

gaagaggaga aagtcgagga tatgtttaac aaggacgatg aggaggacag gcatcacagg     2700

atgccttgtc ctgctcagag tagcatctcg cagggagcaa aaccatggta caaggaattc     2760

ttgcagctga tcggttatag caacttccag agagtggaag aatactgcga gaaagtatgg     2820

tgcacagata gaaagaggaa aaagcttaaa atgtcaccct ccaagtggaa gtatgccaac     2880

cctcaggaaa agaagctccg ttccaaacct gagcattacc gcctgcccag gcacacgctg     2940

gactcctgat ggggtgagac tatctactgt cttttgaaga atttatattt ggaaagtaaa     3000

aaagtaaaaa aataaatcat ccaacttctt tgcattactt aaaagagatt tctgtaatac     3060

aggaatgact atgaaggtgt tataataaat tattctacat actcatttga ctggataaac     3120

tttacataaa attaactaat tttttaaata aatgcattgc ttaatggttt ctcattatgt     3180

ttatcaaaaa acaactgtag ctgttatttt cagtacttgg ctgcttttct gtgaaaatta     3240

ttattttact tttggaagac aagattatta gaatattgaa gaaaaattgg agacttataa     3300

tcatggtaaa tataaaacta aatatgtttt aatatttctg aatttttctt ttccatcaca     3360

atgtaagata tgcagaatac aagatacttt ggcattctca tgtgaacttt ctgtactctt     3420

taaggattat tttattagtg ttgtttaagc catgagtgtt aagtagcagg tgtgttgtga     3480

gtgctgtaac ccatgaaagg aaaaatgtca ttctgaggct tgtgcccttc gtaaaatatt     3540

cattaaagta cattcacact atttttgctt tataacacag tctttaattt tcactcactg     3600

tggaaataaa aactaaggta acttctcaga aagatatcaa atctcagaaa gaatgtcaaa     3660

tcagatgaag ttatagttag gattctaact actgtaaaag atttttgctt ccctcttgtg     3720

gtaaaaaaaa ttatattctc acacatttct tttttctcta cagacggata tctgtttagg     3780

aaagatttga aagcagatta tcagtaggta catggataca tcaagttcat ttgcagaaac     3840

aaataactga aataaaaaac atgttaatcc ttgtatcata ctttaatatg aaagtattgt     3900

ttatagataa tttatctcac aagtcaaaaa tgaagatttt gcagcactga aaatctatta     3960

aagctccaaa ttttaagttt ctaaataatc ttcgctgaaa tctaaaatat actataacaa     4020

ccgtgtttta tttgtgaaaa aaatattaaa gtgatttgct ctcaaatatc aaattttctt     4080

ctctctttta tattaagaga cagaaaattg tttcatgagt tcacttaact actgagatat     4140

tcagagcatt tttacctctc tcttaaatgt tataaaaaac aattgtattt ttaagaatgt     4200

ttatttatca aagtctttcc ttcttctatt aaatatttag caattacctt tctaaaatat     4260

gaaattttgt aagatgtttt cacctaaata aaaattgaaa gcaagtggat tacacaggag     4320

aaccattatg aacatttatt tagatattaa tcttaaacag tgtttatttc agttttcaaa     4380

gttagcttat aggttataca tttaagttaa agtgctcata atcacttgca atttcattgt     4440

aaaatgaaca aatacataaa tattttaaga aaaatttaag tttattcaga taagtcacca     4500

tgcttcaaaa gatctaagaa atgcaaatat actgaaaatt gacatcctct gaaaattcca     4560

cttgctattt acccaagaat ccactggagg tcattactgc cattaaataa taactgaaaa     4620

gactatgtag tgaaatgtat ttttaaaaac tatattcagt aaaagcctgc tcaatttgga     4680

gaaatagaac cacaaacaca gatcacaggg gccttacaaa gtttatgtct gaacaaataa     4740

gtcaattaag tacactttat tgaaaattgc cttccattaa cacacaagaa agaaagcagg     4800

attttctcct gtatctgaat tttaaaatta aaaaggcaga taagacataa atagttatca     4860

ttttaattgc aataacacag acaagtagtt aatgatgata acaatggtgt aacttgtaaa     4920

ctaaatattt ggtaactgaa gcaataggca gaggaaaata gcttttctat gacacaagtc     4980

ataagaagtc catatactga agagcgtttg attaaaataa agtgactatt aaccagaaaa     5040

gaaacatttt acataaaatg ctaaaattta ttataggaaa ataaatcaaa cccaaagaaa     5100

gtttattcaa tgctaatttg aaagaaaatt gataagaaaa ctttgagggc ccaagtccac     5160

aatttggtga gaccactaaa ttttacatat aattatacac acacatatgt acatatatat     5220

gtatataatc ttgcttcccg cctgtttatg gcagtactga agagaaatgg gaaagaagag     5280

ggagggagag agaaagacga agggagagag aaagcagttt ccaaggatat gtttcatgtc     5340

ccaccatttt ctcagtttct ccctctctct cccaacacac acacacacac acccctcaca     5400

tactataaaa taaatcttca ctgccctatc aaaatacaaa taaatcaatc tatgctgttc     5460

tgtccttctt gagaatctaa aacataccac aaaaatacat ccccagtctt ttgttctgtc     5520

tgaggttaga attaattcaa attcagaatc tgttgtgaga aatgcccagg ctttaaaaat     5580

taaaaatgga tggatcttct ctgaactcag ggagggcaca tacttagata cctacaagac     5640

ttggaggaat taagagttca cccttcatct caccaaattt tccccatttt tctctttctt     5700

gtagaaggag agaaaccatg ctctctagca acattgagca aaaatcataa ccactcatct     5760

aatttctaag aggcacctcc atcgagggcc ggtctcctgc ttctttagac ctcttctatc     5820

tttgttacag gagaggacct gtggatagac ttagttttga cataaaacaa tgcccattca     5880

cctcctcctt cagcacaacg tcacccattg ggcaagagat ccagatttgt taacaaaaaa     5940

gattttactt cgtgattcca cgtctataat tctatattgc taattttttc ttttgtgtga     6000

attactgaat atttcagagc aaagctatca acttggagaa acagggatta aaaataagga     6060

taaacactaa taagagctct agaaaaaagg gaacagaaag tctgcctgtt tagtaagtgg     6120

caattccata catattttag agttttttct atctaaaatt agttaaatac ttagaatgtt     6180

tgtaatgagt gttcgatatt tgctataggt tttagggttt tgtaaatctt catagtaatt     6240

ataaacattt gtaaaatttg taaaatacta taagtcattt tgagtgttgg tgttaagcat     6300

gaaacaaaca gcagctgttg tccttaaaaa tgaattgacc tggccgggcg cggtggctca     6360

cgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcatgaggt caggagatcg     6420

agaccatcct ggctaacaag gtgaaacccc gtctctacta aaaatacaaa aaattagccg     6480

ggcgcggtgg cgggcgcctg tagtcccagc tacttgggag gctgaggcag gagaatggcg     6540

tgaacccggg aagcggagct tgcagtgagc cgagattgcg ccactgcagt ccgcagtccg     6600

gcctgggcga cagagcgaga ctccgtctc                                       6629


<210>  98
<211>  1369
<212>  DNA
<213>  Homo sapiens

<400>  98
gaatcattgc actccctact agagcggatg tgatgaggga aaaggagaac tcagcacttt       60

ccctgcagga accggctccc tcggaggggc gtggctggga ggagctgtga gtaacgtgcc      120

acagtgttgt aaaaacccag tgagtgttat aaaaacccag tcagcctggc tcctgttgaa      180

tagtctaccc cccttgcact ctacctgaca cagctgcagc ctgcaattca ctcgcactgc      240

ctgggattgc actggatccg tgtgctcaga acaaggtgaa cgcccagctg cagccatgaa      300

gatctgtagc ctcaccctgc tctccttcct cctactggct gctcaggtgc tcctggtgga      360

ggggaaaaaa aaagtgaaga atggacttca cagcaaagtg gtctcagaac aaaaggacac      420

tctgggcaac acccagatta agcagaaaag caggcccggg aacaaaggca agtttgtcac      480

caaagaccaa gccaactgca gatgggctgc tactgagcag gaggagggca tctctctcaa      540

ggttgagtgc actcaattgg accatgaatt ttcctgtgtc tttgctggca atccaacctc      600

atgcctaaag ctcaaggatg agagagtcta ttggaaacaa gttgcccgga atctgcgctc      660

acagaaagac atctgtagat attccaagac agctgtgaaa accagagtgt gcagaaagga      720

ttttccagaa tccagtctta agctagtcag ctccactcta tttgggaaca caaagcccag      780

gaaggagaaa acagagatgt cccccaggga gcacatcaaa ggcaaagaga ccaccccctc      840

tagcctagca gtgacccaga ccatggccac caaagctccc gagtgtgtgg aggacccaga      900

tatggcaaac cagaggaaga ctgccctgga gttctgtgga gagacttgga gctctctctg      960

cacattcttc ctcagcatag tgcaggacac gtcatgctaa tgaggtcaaa agagaacggg     1020

ttcccttaag agatgtcatg tcgtaagtcc ctctgtatac tttaaagctc tctacagtcc     1080

ccccaaaata tgaacttttg tgcttagtga gtgcaacgaa atatttaaac aagttttgta     1140

ttttttgctt ttgtgttttg gaatttgcct tatttttctt ggatgcgatg ttcagaggct     1200

gtttcctgca gcatgtattt ccatggccca cacagctatg tgtttgagca gcgaagagtc     1260

tttgagctga atgagccaga gtgataattt cagtgcaacg aactttctgc tgaattaatg     1320

gtaataaaac tctgggtgtt tttcagaaat acattcaaaa aaaaaaaaa                 1369


<210>  99
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Phe Ile Trp Thr Ser Gly Arg Thr Ser Ser Ser Tyr Arg His Asp 
1               5                   10                  15      


Glu Lys Arg Asn Ile Tyr Gln Lys Ile Arg Asp His Asp Leu Leu Asp 
            20                  25                  30          


Lys Arg Lys Thr Val Thr Ala Leu Lys Ala Gly Glu Asp Arg Ala Ile 
        35                  40                  45              


Leu Leu Gly Leu Ala Met Met Val Cys Ser Ile Met Met Tyr Phe Leu 
    50                  55                  60                  


Leu Gly Ile Thr Leu Leu Arg Ser Tyr Met Gln Ser Val Trp Thr Glu 
65                  70                  75                  80  


Glu Ser Gln Cys Thr Leu Leu Asn Ala Ser Ile Thr Glu Thr Phe Asn 
                85                  90                  95      


Cys Ser Phe Ser Cys Gly Pro Asp Cys Trp Lys Leu Ser Gln Tyr Pro 
            100                 105                 110         


Cys Leu Gln Val Tyr Val Asn Leu Thr Ser Ser Gly Glu Lys Leu Leu 
        115                 120                 125             


Leu Tyr His Thr Glu Glu Thr Ile Lys Ile Asn Gln Lys Cys Ser Tyr 
    130                 135                 140                 


Ile Pro Lys Cys Gly Lys Asn Phe Glu Glu Ser Met Ser Leu Val Asn 
145                 150                 155                 160 


Val Val Met Glu Asn Phe Arg Lys Tyr Gln His Phe Ser Cys Tyr Ser 
                165                 170                 175     


Asp Pro Glu Gly Asn Gln Lys Ser Val Ile Leu Thr Lys Leu Tyr Ser 
            180                 185                 190         


Ser Asn Val Leu Phe His Ser Leu Phe Trp Pro Thr Cys Met Met Ala 
        195                 200                 205             


Gly Gly Val Ala Ile Val Ala Met Val Lys Leu Thr Gln Tyr Leu Ser 
    210                 215                 220                 


Leu Leu Cys Glu Arg Ile Gln Arg Ile Asn Arg 
225                 230                 235 


<210>  100
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Asp Pro Cys Ser 
1               5                   10                  15      


Thr Gly Phe Val Phe Pro Ala Met Thr Leu Phe Pro Val Leu Leu Phe 
            20                  25                  30          


Leu Val Ala Gly Leu Leu Pro Ser Phe Pro Ala Asn Glu Asp Lys Asp 
        35                  40                  45              


Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln Thr Gln Val Gln Arg Glu 
    50                  55                  60                  


Ile Val Asn Lys His Asn Glu Leu Arg Arg Ala Val Ser Pro Pro Ala 
65                  70                  75                  80  


Arg Asn Met Leu Lys Met Glu Trp Asn Lys Glu Ala Ala Ala Asn Ala 
                85                  90                  95      


Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg His Ser Asn Pro Lys Asp 
            100                 105                 110         


Arg Met Thr Ser Leu Lys Cys Gly Glu Asn Leu Tyr Met Ser Ser Ala 
        115                 120                 125             


Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser Trp Phe Asp Glu Tyr Asn 
    130                 135                 140                 


Asp Phe Asp Phe Gly Val Gly Pro Lys Thr Pro Asn Ala Val Val Gly 
145                 150                 155                 160 


His Tyr Thr Gln Val Val Trp Tyr Ser Ser Tyr Leu Val Gly Cys Gly 
                165                 170                 175     


Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu Lys Tyr Tyr Tyr Val Cys 
            180                 185                 190         


Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn Arg Leu Tyr Val Pro Tyr 
        195                 200                 205             


Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro Asp Asn Cys Asp Asp Gly 
    210                 215                 220                 


Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp Leu Tyr Ser Asn Cys Lys 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Leu Thr Cys Lys His Gln Leu Val Arg Asp Ser 
                245                 250                 255     


Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser Ile Tyr 
            260                 265             


<210>  101
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Thr Val Thr Lys Met Ser Trp Arg Pro Gln Tyr Arg Ser Ser Lys 
1               5                   10                  15      


Phe Arg Asn Val Tyr Gly Lys Val Ala Asn Arg Glu His Cys Phe Asp 
            20                  25                  30          


Gly Ile Pro Ile Thr Lys Asn Val His Asp Asn His Phe Cys Ala Val 
        35                  40                  45              


Asn Thr Arg Phe Leu Ala Ile Val Thr Glu Ser Ala Gly Gly Gly Ser 
    50                  55                  60                  


Phe Leu Val Ile Pro Leu Glu Gln Thr Gly Arg Ile Glu Pro Asn Tyr 
65                  70                  75                  80  


Pro Lys Val Cys Gly His Gln Gly Asn Val Leu Asp Ile Lys Trp Asn 
                85                  90                  95      


Pro Phe Ile Asp Asn Ile Ile Ala Ser Cys Ser Glu Asp Thr Ser Val 
            100                 105                 110         


Arg Ile Trp Glu Ile Pro Glu Gly Gly Leu Lys Arg Asn Met Thr Glu 
        115                 120                 125             


Ala Leu Leu Glu Leu His Gly His Ser Arg Arg Val Gly Leu Val Glu 
    130                 135                 140                 


Trp His Pro Thr Thr Asn Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr 
145                 150                 155                 160 


Lys Val Leu Ile Trp Asn Leu Asp Val Gly Glu Pro Val Lys Met Ile 
                165                 170                 175     


Asp Cys His Thr Asp Val Ile Leu Cys Met Ser Phe Asn Thr Asp Gly 
            180                 185                 190         


Ser Leu Leu Thr Thr Thr Cys Lys Asp Lys Lys Leu Arg Val Ile Glu 
        195                 200                 205             


Pro Arg Ser Gly Arg Val Leu Gln Glu Ala Asn Cys Lys Asn His Arg 
    210                 215                 220                 


Val Asn Arg Val Val Phe Leu Gly Asn Met Lys Arg Leu Leu Thr Thr 
225                 230                 235                 240 


Gly Val Ser Arg Trp Asn Thr Arg Gln Ile Ala Leu Trp Asp Gln Glu 
                245                 250                 255     


Asp Leu Ser Met Pro Leu Ile Glu Glu Glu Ile Asp Gly Leu Ser Gly 
            260                 265                 270         


Leu Leu Phe Pro Phe Tyr Asp Ala Asp Thr His Met Leu Tyr Leu Ala 
        275                 280                 285             


Gly Lys Gly Asp Gly Asn Ile Arg Tyr Tyr Glu Ile Ser Thr Glu Lys 
    290                 295                 300                 


Pro Tyr Leu Ser Tyr Leu Met Glu Phe Arg Ser Pro Ala Pro Gln Lys 
305                 310                 315                 320 


Gly Leu Gly Val Met Pro Lys His Gly Leu Asp Val Ser Ala Cys Glu 
                325                 330                 335     


Val Phe Arg Phe Tyr Lys Leu Val Thr Leu Lys Gly Leu Ile Glu Pro 
            340                 345                 350         


Ile Ser Met Ile Val Pro Arg Arg Ser Asp Ser Tyr Gln Glu Asp Ile 
        355                 360                 365             


Tyr Pro Met Thr Pro Gly Thr Glu Pro Ala Leu Thr Pro Asp Glu Trp 
    370                 375                 380                 


Leu Gly Gly Ile Asn Arg Asp Pro Val Leu Met Ser Leu Lys Glu Gly 
385                 390                 395                 400 


Tyr Lys Lys Ser Ser Lys Met Val Phe Lys Ala Pro Ile Lys Glu Lys 
                405                 410                 415     


Lys Ser Val Val Val Asn Gly Ile Asp Leu Leu Glu Asn Val Pro Pro 
            420                 425                 430         


Arg Thr Glu Asn Glu Leu Leu Arg Met Phe Phe Arg Gln Gln Asp Glu 
        435                 440                 445             


Ile Arg Arg Leu Lys Glu Glu Leu Ala Gln Lys Asp Ile Arg Ile Arg 
    450                 455                 460                 


Gln Leu Gln Leu Glu Leu Lys Asn Leu Arg Asn Ser Pro Lys Asn Cys 
465                 470                 475                 480 


<210>  102
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro 
1               5                   10                  15      


Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Thr Ala Thr Asp Leu 
            20                  25                  30          


Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro 
        35                  40                  45              


Glu Thr Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser 
    50                  55                  60                  


Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro 
65                  70                  75                  80  


Lys Glu Thr Pro Ala Leu Thr Ile Asn Arg Leu Cys Gly Ser Gly Phe 
                85                  90                  95      


Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu 
            100                 105                 110         


Val Val Leu Cys Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Tyr Cys 
        115                 120                 125             


Val Arg Asn Val Arg Phe Gly Thr Lys Leu Gly Ser Asp Ile Lys Leu 
    130                 135                 140                 


Glu Asp Ser Leu Trp Val Ser Leu Thr Asp Gln His Val Gln Leu Pro 
145                 150                 155                 160 


Met Ala Met Thr Ala Glu Asn Leu Ala Val Lys His Lys Ile Ser Arg 
                165                 170                 175     


Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala 
            180                 185                 190         


Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val 
        195                 200                 205             


Lys Thr Lys Lys Gly Lys Gln Thr Met Gln Val Asp Glu His Ala Arg 
    210                 215                 220                 


Pro Gln Thr Thr Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys 
225                 230                 235                 240 


Lys Asp Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Val Ala Asp Gly 
                245                 250                 255     


Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn 
            260                 265                 270         


Phe Thr Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp 
        275                 280                 285             


Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu 
    290                 295                 300                 


Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn 
305                 310                 315                 320 


Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu 
                325                 330                 335     


Asp Ile Ser Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His 
            340                 345                 350         


Pro Leu Gly Gly Ser Gly Ser Arg Ile Thr Ala His Leu Val His Glu 
        355                 360                 365             


Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly 
    370                 375                 380                 


Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Thr Ala 
385                 390                 395         


<210>  103
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Asn Arg Thr Ala Met Arg Ala Ser Gln Lys Asp Phe Glu Asn Ser 
1               5                   10                  15      


Met Asn Gln Val Lys Leu Leu Lys Lys Asp Pro Gly Asn Glu Val Lys 
            20                  25                  30          


Leu Lys Leu Tyr Ala Leu Tyr Lys Gln Ala Thr Glu Gly Pro Cys Asn 
        35                  40                  45              


Met Pro Lys Pro Gly Val Phe Asp Leu Ile Asn Lys Ala Lys Trp Asp 
    50                  55                  60                  


Ala Trp Asn Ala Leu Gly Ser Leu Pro Lys Glu Ala Ala Arg Gln Asn 
65                  70                  75                  80  


Tyr Val Asp Leu Val Ser Ser Leu Ser Pro Ser Leu Glu Ser Ser Ser 
                85                  90                  95      


Gln Val Glu Pro Gly Thr Asp Arg Lys Ser Thr Gly Phe Glu Thr Leu 
            100                 105                 110         


Val Val Thr Ser Glu Asp Gly Ile Thr Lys Ile Met Phe Asn Arg Pro 
        115                 120                 125             


Lys Lys Lys Asn Ala Ile Asn Thr Glu Met Tyr His Glu Ile Met Arg 
    130                 135                 140                 


Ala Leu Lys Ala Ala Ser Lys Asp Asp Ser Ile Ile Thr Val Leu Thr 
145                 150                 155                 160 


Gly Asn Gly Asp Tyr Tyr Ser Ser Gly Asn Asp Leu Thr Asn Phe Thr 
                165                 170                 175     


Asp Ile Pro Pro Gly Gly Val Glu Glu Lys Ala Lys Asn Asn Ala Val 
            180                 185                 190         


Leu Leu Arg Glu Phe Val Gly Cys Phe Ile Asp Phe Pro Lys Pro Leu 
        195                 200                 205             


Ile Ala Val Val Asn Gly Pro Ala Val Gly Ile Ser Val Thr Leu Leu 
    210                 215                 220                 


Gly Leu Phe Asp Ala Val Tyr Ala Ser Asp Arg Ala Thr Phe His Thr 
225                 230                 235                 240 


Pro Phe Ser His Leu Gly Gln Ser Pro Glu Gly Cys Ser Ser Tyr Thr 
                245                 250                 255     


Phe Pro Lys Ile Met Ser Pro Ala Lys Ala Thr Glu Met Leu Ile Phe 
            260                 265                 270         


Gly Lys Lys Leu Thr Ala Gly Glu Ala Cys Ala Gln Gly Leu Val Thr 
        275                 280                 285             


Glu Val Phe Pro Asp Ser Thr Phe Gln Lys Glu Val Trp Thr Arg Leu 
    290                 295                 300                 


Lys Ala Phe Ala Lys Leu Pro Pro Asn Ala Leu Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Val Ile Arg Lys Arg Glu Arg Glu Lys Leu His Ala Val Asn Ala Glu 
                325                 330                 335     


Glu Cys Asn Val Leu Gln Gly Arg Trp Leu Ser Asp Glu Cys Thr Asn 
            340                 345                 350         


Ala Val Val Asn Phe Leu Ser Arg Lys Ser Lys Leu 
        355                 360                 


<210>  104
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  105
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  106
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Ser Gly Gln Phe Val Asn Lys Leu Gln Glu Glu Val Ile Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Ile Leu Gln Lys Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Leu Lys Cys Ile Thr Gln Ile Gly Glu Thr Ser Cys 
        35                  40                  45              


Gly Phe Phe Lys Cys Pro Leu Cys Lys Thr Ser Val Arg Lys Asn Ala 
    50                  55                  60                  


Ile Arg Phe Asn Ser Leu Leu Arg Asn Leu Val Glu Lys Ile Gln Ala 
65                  70                  75                  80  


Leu Gln Ala Ser Glu Val Gln Ser Lys Arg Lys Glu Ala Thr Cys Pro 
                85                  90                  95      


Arg His Gln Glu Met Phe His Tyr Phe Cys Glu Asp Asp Gly Lys Phe 
            100                 105                 110         


Leu Cys Phe Val Cys Arg Glu Ser Lys Asp His Lys Ser His Asn Val 
        115                 120                 125             


Ser Leu Ile Glu Glu Ala Ala Gln Asn Tyr Gln Gly Gln Ile Gln Glu 
    130                 135                 140                 


Gln Ile Gln Val Leu Gln Gln Lys Glu Lys Glu Thr Val Gln Val Lys 
145                 150                 155                 160 


Ala Gln Gly Val His Arg Val Asp Val Phe Thr Asp Gln Val Glu His 
                165                 170                 175     


Glu Lys Gln Arg Ile Leu Thr Glu Phe Glu Leu Leu His Gln Val Leu 
            180                 185                 190         


Glu Glu Glu Lys Asn Phe Leu Leu Ser Arg Ile Tyr Trp Leu Gly His 
        195                 200                 205             


Glu Gly Thr Glu Ala Gly Lys His Tyr Val Ala Ser Thr Glu Pro Gln 
    210                 215                 220                 


Leu Asn Asp Leu Lys Lys Leu Val Asp Ser Leu Lys Thr Lys Gln Asn 
225                 230                 235                 240 


Met Pro Pro Arg Gln Leu Leu Glu Asp Ile Lys Val Val Leu Cys Arg 
                245                 250                 255     


Ser Glu Glu Phe Gln Phe Leu Asn Pro Thr Pro Val Pro Leu Glu Leu 
            260                 265                 270         


Glu Lys Lys Leu Ser Glu Ala Lys Ser Arg His Asp Ser Ile Thr Gly 
        275                 280                 285             


Ser Leu Lys Lys Phe Lys Asp Gln Leu Gln Ala Asp Arg Lys Lys Asp 
    290                 295                 300                 


Glu Asn Arg Phe Phe Lys Ser Met Asn Lys Asn Asp Met Lys Ser Trp 
305                 310                 315                 320 


Gly Leu Leu Gln Lys Asn Asn His Lys Met Asn Lys Thr Ser Glu Pro 
                325                 330                 335     


Gly Ser Ser Ser Ala Gly Gly Arg Thr Thr Ser Gly Pro Pro Asn His 
            340                 345                 350         


His Ser Ser Ala Pro Ser His Ser Leu Phe Arg Ala Ser Ser Ala Gly 
        355                 360                 365             


Lys Val Thr Phe Pro Val Cys Leu Leu Ala Ser Tyr Asp Glu Ile Ser 
    370                 375                 380                 


Gly Gln Gly Ala Ser Ser Gln Asp Thr Lys Thr Phe Asp Val Ala Leu 
385                 390                 395                 400 


Ser Glu Glu Leu His Ala Ala Leu Ser Glu Trp Leu Thr Ala Ile Arg 
                405                 410                 415     


Ala Trp Phe Cys Glu Val Pro Ser Ser 
            420                 425 


<210>  107
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Arg Arg Ser Ala Phe Pro Ala Ala Ala Leu Trp Leu Trp Ser 
1               5                   10                  15      


Ile Leu Leu Cys Leu Leu Ala Leu Arg Ala Glu Ala Gly Pro Pro Gln 
            20                  25                  30          


Glu Glu Ser Leu Tyr Leu Trp Ile Asp Ala His Gln Ala Arg Val Leu 
        35                  40                  45              


Ile Gly Phe Glu Glu Asp Ile Leu Ile Val Ser Glu Gly Lys Met Ala 
    50                  55                  60                  


Pro Phe Thr His Asp Phe Arg Lys Ala Gln Gln Arg Met Pro Ala Ile 
65                  70                  75                  80  


Pro Val Asn Ile His Ser Met Asn Phe Thr Trp Gln Ala Ala Gly Gln 
                85                  90                  95      


Ala Glu Tyr Phe Tyr Glu Phe Leu Ser Leu Arg Ser Leu Asp Lys Gly 
            100                 105                 110         


Ile Met Ala Asp Pro Thr Val Asn Val Pro Leu Leu Gly Thr Val Pro 
        115                 120                 125             


His Lys Ala Ser Val Val Gln Val Gly Phe Pro Cys Leu Gly Lys Gln 
    130                 135                 140                 


Asp Gly Val Ala Ala Phe Glu Val Asp Val Ile Val Met Asn Ser Glu 
145                 150                 155                 160 


Gly Asn Thr Ile Leu Gln Thr Pro Gln Asn Ala Ile Phe Phe Lys Thr 
                165                 170                 175     


Cys Gln Gln Ala Glu Cys Pro Gly Gly Cys Arg Asn Gly Gly Phe Cys 
            180                 185                 190         


Asn Glu Arg Arg Ile Cys Glu Cys Pro Asp Gly Phe His Gly Pro His 
        195                 200                 205             


Cys Glu Lys Ala Leu Cys Thr Pro Arg Cys Met Asn Gly Gly Leu Cys 
    210                 215                 220                 


Val Thr Pro Gly Phe Cys Ile Cys Pro Pro Gly Phe Tyr Gly Val Asn 
225                 230                 235                 240 


Cys Asp Lys Ala Asn Cys Ser Thr Thr Cys Phe Asn Gly Gly Thr Cys 
                245                 250                 255     


Phe Tyr Pro Gly Lys Cys Ile Cys Pro Pro Gly Leu Glu Gly Glu Gln 
            260                 265                 270         


Cys Glu Ile Ser Lys Cys Pro Gln Pro Cys Arg Asn Gly Gly Lys Cys 
        275                 280                 285             


Ile Gly Lys Ser Lys Cys Lys Cys Ser Lys Gly Tyr Gln Gly Asp Leu 
    290                 295                 300                 


Cys Ser Lys Pro Val Cys Glu Pro Gly Cys Gly Ala His Gly Thr Cys 
305                 310                 315                 320 


His Glu Pro Asn Lys Cys Gln Cys Gln Glu Gly Trp His Gly Arg His 
                325                 330                 335     


Cys Asn Lys Arg Tyr Glu Ala Ser Leu Ile His Ala Leu Arg Pro Ala 
            340                 345                 350         


Gly Ala Gln Leu Arg Gln His Thr Pro Ser Leu Lys Lys Ala Glu Glu 
        355                 360                 365             


Arg Arg Asp Pro Pro Glu Ser Asn Tyr Ile Trp 
    370                 375                 


<210>  108
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Ala Glu Arg Leu 
        35                  40                  45              


Ser Ser Ser Trp Leu Asp Val Arg His Ile Glu Lys Tyr Val Asp Gln 
    50                  55                  60                  


Gly Lys Ser Gly Thr Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys Asn 
65                  70                  75                  80  


Lys Thr Ile Gly Asp Leu Leu Gln Val Leu Gln Glu Met Gly His Arg 
                85                  90                  95      


Arg Ala Ile His Leu Ile Thr Asn Tyr Gly Ala Val Leu Ser Pro Ser 
            100                 105                 110         


Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu Phe Lys Glu 
        115                 120                 125             


Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu His Asn Glu 
    130                 135                 140                 


Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn Ile Ile Glu 
145                 150                 155                 160 


Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu Gly Glu Ile 
                165                 170                 175     


Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr Ala Val Lys 
            180                 185                 190         


Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His Trp Lys Arg 
        195                 200                 205             


Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His Pro Asn Ile 
    210                 215                 220                 


Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe Cys Leu Ile 
225                 230                 235                 240 


Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu Gln Cys Val 
                245                 250                 255     


Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly Ile Leu Ile 
            260                 265                 270         


Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln Pro Cys Ser 
        275                 280                 285             


Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu Asp Asp Gln 
    290                 295                 300                 


Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe Arg Ser His 
305                 310                 315                 320 


Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser Ser Ser Lys 
                325                 330                 335     


His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly Lys Leu Ser 
            340                 345                 350         


Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met Glu Val Leu 
        355                 360                 365             


Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile Gln Leu Arg 
    370                 375                 380                 


Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp Ser Cys Leu 
385                 390                 395                 400 


Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn Phe Ser Ala 
                405                 410                 415     


Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg Ala Lys Leu 
            420                 425                 430         


Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser Thr Gln Ala 
        435                 440                 445             


Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys Ser Phe Arg 
    450                 455                 460                 


Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile Pro Val Glu 
465                 470                 475                 480 


Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp Glu Gly Leu 
                485                 490                 495     


Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys Ser Gln Ser 
            500                 505                 510         


Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser Lys Arg Asn 
        515                 520                 525             


Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu Ser Trp Phe 
    530                 535                 540                 


Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr Lys Val Asn 
545                 550                 555                 560 


Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg Ser Arg Pro 
                565                 570                 575     


Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu Tyr Glu Gln 
            580                 585                 590         


Tyr Lys Lys Glu 
        595     


<210>  109
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Lys Leu Val Thr Ile Phe Leu Leu Val Thr Ile Ser Leu Cys Ser 
1               5                   10                  15      


Tyr Ser Ala Thr Ala Phe Leu Ile Asn Lys Val Pro Leu Pro Val Asp 
            20                  25                  30          


Lys Leu Ala Pro Leu Pro Leu Asp Asn Ile Leu Pro Phe Met Asp Pro 
        35                  40                  45              


Leu Lys Leu Leu Leu Lys Thr Leu Gly Ile Ser Val Glu His Leu Val 
    50                  55                  60                  


Glu Gly Leu Arg Lys Cys Val Asn Glu Leu Gly Pro Glu Ala Ser Glu 
65                  70                  75                  80  


Ala Val Lys Lys Leu Leu Glu Ala Leu Ser His Leu Val 
                85                  90              


<210>  110
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro 
                165                 170                 175     


Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala 
            180                 185                 190         


Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp 
        195                 200                 205             


Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys 
    210                 215                 220                 


Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His 
225                 230                 235                 240 


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
                245                 250                 255     


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile 
            260                 265                 270         


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
        275                 280                 285             


Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro 
    290                 295                 300                 


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala 
                325                 330                 335     


Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
            340                 345             


<210>  111
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala 
        355                 360                 365             


Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp 
705                 710                 715                 720 


Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr 
                725                 730                 735     


Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln 
    930                 935                 940                 


Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Thr Tyr Thr  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Thr Leu Thr Ala  Tyr Ile Val 
    1040                 1045                 1050             


Thr Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Thr Leu Ala  Leu Ile Thr Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Thr Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Thr 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Thr Gln Asp Thr Thr  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Thr  Glu Arg Thr 
    1190                 1195                 1200             


Asn Ile  Gln Val Thr Val Thr  Gly Pro Ser Ser Pro  Ser Pro Val 
    1205                 1210                 1215             


Lys Phe  Leu Ile Asp Thr His  Asn Arg Leu Leu Leu  Gln Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Val Val Gln Pro  Thr Ala Val Asn Ile  Ser Ala Asn 
    1235                 1240                 1245             


Gly Phe  Gly Phe Ala Ile Cys  Gln Leu Asn Val Val  Tyr Asn Val 
    1250                 1255                 1260             


Lys Ala  Ser Gly Ser Ser Arg  Arg Arg Arg Ser Ile  Gln Asn Gln 
    1265                 1270                 1275             


Glu Ala  Phe Asp Leu Asp Val  Ala Val Lys Glu Asn  Lys Asp Asp 
    1280                 1285                 1290             


Leu Asn  His Val Asp Leu Asn  Val Cys Thr Ser Phe  Ser Gly Pro 
    1295                 1300                 1305             


Gly Arg  Ser Gly Met Ala Leu  Met Glu Val Asn Leu  Leu Ser Gly 
    1310                 1315                 1320             


Phe Met  Val Pro Ser Glu Ala  Ile Ser Leu Ser Glu  Thr Val Lys 
    1325                 1330                 1335             


Lys Val  Glu Tyr Asp His Gly  Lys Leu Asn Leu Tyr  Leu Asp Ser 
    1340                 1345                 1350             


Val Asn  Glu Thr Gln Phe Cys  Val Asn Ile Pro Ala  Val Arg Asn 
    1355                 1360                 1365             


Phe Lys  Val Ser Asn Thr Gln  Asp Ala Ser Val Ser  Ile Val Asp 
    1370                 1375                 1380             


Tyr Tyr  Glu Pro Arg Arg Gln  Ala Val Arg Ser Tyr  Asn Ser Glu 
    1385                 1390                 1395             


Val Lys  Leu Ser Ser Cys Asp  Leu Cys Ser Asp Val  Gln Gly Cys 
    1400                 1405                 1410             


Arg Pro  Cys Glu Asp Gly Ala  Ser Gly Ser His His  His Ser Ser 
    1415                 1420                 1425             


Val Ile  Phe Ile Phe Cys Phe  Lys Leu Leu Tyr Phe  Met Glu Leu 
    1430                 1435                 1440             


Trp Leu  
    1445 


<210>  112
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Asp Pro Ala Val Ala Leu Val Leu Cys Leu Ser Cys Leu Phe Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Arg Leu Pro Ser Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Ile Leu Gln Leu Asp Val Lys 
        35                  40                  45              


Asp Met Ser Lys Ser Leu Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp His Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ser Phe Pro Val Ala Glu Lys Val Asn Lys Gly Leu Gly Ile 
            100                 105                 110         


Leu Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Cys Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Asn 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Ile Phe His Asp Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Arg Phe Leu Asn Leu Met Glu Lys Phe Asn Glu Asn Leu Arg Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Ala Leu Ile Asp 
    210                 215                 220                 


Tyr Leu Pro Gly Ser His Asn Lys Ile Ala Glu Asn Phe Ala Tyr Ile 
225                 230                 235                 240 


Lys Ser Tyr Val Leu Glu Arg Ile Lys Glu His Gln Glu Ser Leu Asp 
                245                 250                 255     


Met Asn Ser Ala Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys His Asn Gln Gln Ser Glu Phe Thr Val Glu Ser Leu Ile 
        275                 280                 285             


Ala Thr Val Thr Asp Met Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys Tyr Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Cys Val Val Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ile Asp Leu Leu Pro Thr Asn Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Lys Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Ile Thr Ser Leu Thr Ser Val Leu His Asn Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Lys Ser 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Met Cys Met Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Gln Val Asp Pro 
    450                 455                 460                 


Lys Asp Ile Asp Ile Thr Pro Ile Ala Asn Ala Phe Gly Arg Val Pro 
465                 470                 475                 480 


Pro Leu Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  113
<211>  3088
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Glu Phe Leu Gln Arg Ala Lys Ser Lys Leu Asn Arg Ser Lys 
1               5                   10                  15      


Arg Leu Glu Lys Val His Val Val Ile Gly Pro Lys Ser Cys Asp Leu 
            20                  25                  30          


Asp Ser Leu Ile Ser Thr Phe Thr Tyr Ala Tyr Phe Leu Asp Lys Val 
        35                  40                  45              


Ser Pro Pro Gly Val Leu Cys Leu Pro Val Leu Asn Ile Pro Arg Thr 
    50                  55                  60                  


Glu Phe Asn Tyr Phe Thr Glu Thr Arg Phe Ile Leu Glu Glu Leu Asn 
65                  70                  75                  80  


Ile Ser Glu Ser Phe His Ile Phe Arg Asp Glu Ile Asn Leu His Gln 
                85                  90                  95      


Leu Asn Asp Glu Gly Lys Leu Ser Ile Thr Leu Val Gly Ser Ser Val 
            100                 105                 110         


Leu Ala Ser Glu Asp Lys Thr Leu Glu Ser Ala Val Val Lys Val Ile 
        115                 120                 125             


Asn Pro Val Glu Gln Ser Asp Ala Asn Val Glu Phe Arg Glu Ser Ser 
    130                 135                 140                 


Ser Ser Leu Val Leu Lys Glu Ile Leu Gln Glu Ala Pro Glu Leu Ile 
145                 150                 155                 160 


Thr Glu Gln Leu Ala His Arg Leu Arg Gly Ser Ile Leu Phe Lys Trp 
                165                 170                 175     


Met Thr Met Glu Ser Glu Lys Ile Ser Glu Lys Gln Glu Glu Ile Leu 
            180                 185                 190         


Ser Ile Leu Glu Glu Lys Phe Pro Asn Leu Pro Pro Arg Glu Asp Ile 
        195                 200                 205             


Ile Asn Val Leu Gln Glu Thr Gln Phe Ser Ala Gln Gly Leu Ser Ile 
    210                 215                 220                 


Glu Gln Thr Met Leu Lys Asp Leu Lys Glu Leu Ser Asp Gly Glu Ile 
225                 230                 235                 240 


Lys Val Ala Ile Ser Thr Val Ser Met Asn Leu Glu Asn Cys Leu Phe 
                245                 250                 255     


His Ser Asn Ile Thr Ser Asp Leu Lys Ala Phe Thr Asp Lys Phe Gly 
            260                 265                 270         


Phe Asp Val Leu Ile Leu Phe Ser Ser Tyr Leu Ser Glu Glu Gln Gln 
        275                 280                 285             


Pro Arg Arg Gln Ile Ala Val Tyr Ser Glu Asn Met Glu Leu Cys Ser 
    290                 295                 300                 


Gln Ile Cys Cys Glu Leu Glu Glu Cys Gln Asn Pro Cys Leu Glu Leu 
305                 310                 315                 320 


Glu Pro Phe Asp Cys Gly Cys Asp Glu Ile Leu Val Tyr Gln Gln Glu 
                325                 330                 335     


Asp Pro Ser Val Thr Cys Asp Gln Val Val Leu Val Val Lys Glu Val 
            340                 345                 350         


Ile Asn Arg Arg Cys Pro Glu Met Val Ser Asn Ser Arg Thr Ser Ser 
        355                 360                 365             


Thr Glu Ala Val Ala Gly Ser Ala Pro Leu Ser Gln Gly Ser Ser Gly 
    370                 375                 380                 


Ile Met Glu Leu Tyr Gly Ser Asp Ile Glu Pro Gln Pro Ser Ser Val 
385                 390                 395                 400 


Asn Phe Ile Glu Asn Pro Pro Asp Leu Asn Asp Ser Asn Gln Ala Gln 
                405                 410                 415     


Val Asp Ala Asn Val Asp Leu Val Ser Pro Asp Ser Gly Leu Ala Thr 
            420                 425                 430         


Ile Arg Ser Ser Arg Ser Ser Lys Glu Ser Ser Val Phe Leu Ser Asp 
        435                 440                 445             


Asp Ser Pro Val Gly Glu Gly Ala Gly Pro His His Thr Leu Leu Pro 
    450                 455                 460                 


Gly Leu Asp Ser Tyr Ser Pro Ile Pro Glu Gly Ala Val Ala Glu Glu 
465                 470                 475                 480 


His Ala Trp Ser Gly Glu His Gly Glu His Phe Asp Leu Phe Asn Phe 
                485                 490                 495     


Asp Pro Ala Pro Met Ala Ser Gly Gln Ser Gln Gln Ser Ser His Ser 
            500                 505                 510         


Ala Asp Tyr Ser Pro Ala Asp Asp Phe Phe Pro Asn Ser Asp Leu Ser 
        515                 520                 525             


Glu Gly Gln Leu Pro Ala Gly Pro Glu Gly Leu Asp Gly Met Gly Thr 
    530                 535                 540                 


Asn Met Ser Asn Tyr Ser Ser Ser Ser Leu Leu Ser Gly Ala Gly Lys 
545                 550                 555                 560 


Asp Ser Leu Val Glu His Asp Glu Glu Phe Val Gln Arg Gln Asp Ser 
                565                 570                 575     


Pro Arg Asp Asn Ser Glu Arg Asn Leu Ser Leu Thr Asp Phe Val Gly 
            580                 585                 590         


Asp Glu Ser Pro Ser Pro Glu Arg Leu Lys Asn Thr Gly Lys Arg Ile 
        595                 600                 605             


Pro Pro Thr Pro Met Asn Ser Leu Val Glu Ser Ser Pro Ser Thr Glu 
    610                 615                 620                 


Glu Pro Ala Ser Leu Tyr Thr Glu Asp Met Thr Gln Lys Ala Thr Asp 
625                 630                 635                 640 


Thr Gly His Met Gly Pro Pro Gln Thr His Ala Arg Cys Ser Ser Trp 
                645                 650                 655     


Trp Gly Gly Leu Glu Ile Asp Ser Lys Asn Ile Ala Asp Ala Trp Ser 
            660                 665                 670         


Ser Ser Glu Gln Glu Ser Val Phe Gln Ser Pro Glu Ser Trp Lys Glu 
        675                 680                 685             


His Lys Pro Ser Ser Ile Asp Arg Arg Ala Ser Asp Ser Val Phe Gln 
    690                 695                 700                 


Pro Lys Ser Leu Glu Phe Thr Lys Ser Gly Pro Trp Glu Ser Glu Phe 
705                 710                 715                 720 


Gly Gln Pro Glu Leu Gly Ser Asn Asp Ile Gln Asp Lys Asn Glu Glu 
                725                 730                 735     


Ser Leu Pro Phe Gln Asn Leu Pro Met Glu Lys Ser Pro Leu Pro Asn 
            740                 745                 750         


Thr Ser Pro Gln Gly Thr Asn His Leu Ile Glu Asp Phe Ala Ser Leu 
        755                 760                 765             


Trp His Ser Gly Arg Ser Pro Thr Ala Met Pro Glu Pro Trp Gly Asn 
    770                 775                 780                 


Pro Thr Asp Asp Gly Glu Pro Ala Ala Val Ala Pro Phe Pro Ala Trp 
785                 790                 795                 800 


Ser Ala Phe Gly Lys Glu Asp His Asp Glu Ala Leu Lys Asn Thr Trp 
                805                 810                 815     


Asn Leu His Pro Thr Ser Ser Lys Thr Pro Ser Val Arg Asp Pro Asn 
            820                 825                 830         


Glu Trp Ala Met Ala Lys Ser Gly Phe Ala Phe Ser Ser Ser Glu Leu 
        835                 840                 845             


Leu Asp Asn Ser Pro Ser Glu Ile Asn Asn Glu Ala Ala Pro Glu Ile 
    850                 855                 860                 


Trp Gly Lys Lys Asn Asn Asp Ser Arg Asp His Ile Phe Ala Pro Gly 
865                 870                 875                 880 


Asn Pro Ser Ser Asp Leu Asp His Thr Trp Thr Asn Ser Lys Pro Pro 
                885                 890                 895     


Lys Glu Asp Gln Asn Gly Leu Val Asp Pro Lys Thr Arg Gly Lys Val 
            900                 905                 910         


Tyr Glu Lys Val Asp Ser Trp Asn Leu Phe Glu Glu Asn Met Lys Lys 
        915                 920                 925             


Gly Gly Ser Asp Val Leu Val Pro Trp Glu Asp Ser Phe Leu Ser Tyr 
    930                 935                 940                 


Lys Cys Ser Asp Tyr Ser Ala Ser Asn Leu Gly Glu Asp Ser Val Pro 
945                 950                 955                 960 


Ser Pro Leu Asp Thr Asn Tyr Ser Thr Ser Asp Ser Tyr Thr Ser Pro 
                965                 970                 975     


Thr Phe Ala Gly Asp Glu Lys Glu Thr Glu His Lys Pro Phe Ala Lys 
            980                 985                 990         


Glu Glu Gly Phe Glu Ser Lys Asp  Gly Asn Ser Thr Ala  Glu Glu Thr 
        995                 1000                 1005             


Asp Ile  Pro Pro Gln Ser Leu  Gln Gln Ser Ser Arg  Asn Arg Ile 
    1010                 1015                 1020             


Ser Ser  Gly Pro Gly Asn Leu  Asp Met Trp Ala Ser  Pro His Thr 
    1025                 1030                 1035             


Asp Asn  Ser Ser Glu Ile Asn  Thr Thr His Asn Leu  Asp Glu Asn 
    1040                 1045                 1050             


Glu Leu  Lys Thr Glu His Thr  Asp Gly Lys Asn Ile  Ser Met Glu 
    1055                 1060                 1065             


Asp Asp  Val Gly Glu Ser Ser  Gln Ser Ser Tyr Asp  Asp Pro Ser 
    1070                 1075                 1080             


Met Met  Gln Leu Tyr Asn Glu  Thr Asn Arg Gln Leu  Thr Leu Leu 
    1085                 1090                 1095             


His Ser  Ser Thr Asn Ser Arg  Gln Thr Ala Pro Asp  Ser Leu Asp 
    1100                 1105                 1110             


Leu Trp  Asn Arg Val Ile Leu  Glu Asp Thr Gln Ser  Thr Ala Thr 
    1115                 1120                 1125             


Ile Ser  Asp Met Asp Asn Asp  Leu Asp Trp Asp Asp  Cys Ser Gly 
    1130                 1135                 1140             


Gly Ala  Ala Ile Pro Ser Asp  Gly Gln Thr Glu Gly  Tyr Met Ala 
    1145                 1150                 1155             


Glu Gly  Ser Glu Pro Glu Thr  Arg Phe Thr Val Arg  Gln Leu Glu 
    1160                 1165                 1170             


Pro Trp  Gly Leu Glu Tyr Gln  Glu Ala Asn Gln Val  Asp Trp Glu 
    1175                 1180                 1185             


Leu Pro  Ala Ser Asp Glu His  Thr Lys Asp Ser Ala  Pro Ser Glu 
    1190                 1195                 1200             


His His  Thr Leu Asn Glu Lys  Ser Gly Gln Leu Ile  Ala Asn Ser 
    1205                 1210                 1215             


Ile Trp  Asp Ser Val Met Arg  Asp Lys Asp Met Ser  Ser Phe Met 
    1220                 1225                 1230             


Leu Pro  Gly Ser Ser His Ile  Thr Asp Ser Glu Gln  Arg Glu Leu 
    1235                 1240                 1245             


Pro Pro  Glu Ile Pro Ser His  Ser Ala Asn Val Lys  Asp Thr His 
    1250                 1255                 1260             


Ser Pro  Asp Ala Pro Ala Ala  Ser Gly Thr Ser Glu  Ser Glu Ala 
    1265                 1270                 1275             


Leu Ile  Ser His Leu Asp Lys  Gln Asp Thr Glu Arg  Glu Thr Leu 
    1280                 1285                 1290             


Gln Ser  Asp Ala Ala Ser Leu  Ala Thr Arg Leu Glu  Asn Pro Gly 
    1295                 1300                 1305             


Tyr Phe  Pro His Pro Asp Pro  Trp Lys Gly His Gly  Asp Gly Gln 
    1310                 1315                 1320             


Ser Glu  Ser Glu Lys Glu Ala  Gln Gly Ala Thr Asp  Arg Gly His 
    1325                 1330                 1335             


Leu Asp  Glu Glu Glu Val Ile  Ala Ser Gly Val Glu  Asn Ala Ser 
    1340                 1345                 1350             


Gly Ile  Ser Glu Lys Gly Gln  Ser Asp Gln Glu Leu  Ser Ser Leu 
    1355                 1360                 1365             


Val Ala  Ser Glu His Gln Glu  Ile Cys Ile Lys Ser  Gly Lys Ile 
    1370                 1375                 1380             


Ser Ser  Leu Ala Val Thr Phe  Ser Pro Gln Thr Glu  Glu Pro Glu 
    1385                 1390                 1395             


Glu Val  Leu Glu Tyr Glu Glu  Gly Ser Tyr Asn Leu  Asp Ser Arg 
    1400                 1405                 1410             


Asp Val  Gln Thr Gly Met Ser  Ala Asp Asn Leu Gln  Pro Lys Asp 
    1415                 1420                 1425             


Thr His  Glu Lys His Leu Met  Ser Gln Arg Asn Ser  Gly Glu Thr 
    1430                 1435                 1440             


Thr Glu  Thr Ser Asp Gly Met  Asn Phe Thr Lys Tyr  Val Ser Val 
    1445                 1450                 1455             


Pro Glu  Lys Asp Leu Glu Lys  Thr Glu Glu Cys Asn  Phe Leu Glu 
    1460                 1465                 1470             


Pro Glu  Asn Val Gly Gly Gly  Pro Pro His Arg Val  Pro Arg Ser 
    1475                 1480                 1485             


Leu Asp  Phe Gly Asp Val Pro  Ile Asp Ser Asp Val  His Val Ser 
    1490                 1495                 1500             


Ser Thr  Cys Ser Glu Ile Thr  Lys Asn Leu Asp Val  Lys Gly Ser 
    1505                 1510                 1515             


Glu Asn  Ser Leu Pro Gly Ala  Gly Ser Ser Gly Asn  Phe Asp Arg 
    1520                 1525                 1530             


Asp Thr  Ile Ser Ser Glu Tyr  Thr His Ser Ser Ala  Ser Ser Pro 
    1535                 1540                 1545             


Glu Leu  Asn Asp Ser Ser Val  Ala Leu Ser Ser Trp  Gly Gln Gln 
    1550                 1555                 1560             


Pro Ser  Ser Gly Tyr Gln Glu  Glu Asn Gln Gly Asn  Trp Ser Glu 
    1565                 1570                 1575             


Gln Asn  His Gln Glu Ser Glu  Leu Ile Thr Thr Asp  Gly Gln Val 
    1580                 1585                 1590             


Glu Ile  Val Thr Lys Val Lys  Asp Leu Glu Lys Asn  Arg Ile Asn 
    1595                 1600                 1605             


Glu Phe  Glu Lys Ser Phe Asp  Arg Lys Thr Pro Thr  Phe Leu Glu 
    1610                 1615                 1620             


Ile Trp  Asn Asp Ser Val Asp  Gly Asp Ser Phe Ser  Ser Leu Ser 
    1625                 1630                 1635             


Ser Pro  Glu Thr Gly Lys Tyr  Ser Glu His Ser Gly  Thr His Gln 
    1640                 1645                 1650             


Glu Ser  Asn Leu Ile Ala Ser  Tyr Gln Glu Lys Asn  Glu His Asp 
    1655                 1660                 1665             


Ile Ser  Ala Thr Val Gln Pro  Glu Asp Ala Arg Val  Ile Ser Thr 
    1670                 1675                 1680             


Ser Ser  Gly Ser Asp Asp Asp  Ser Val Gly Gly Glu  Glu Ser Ile 
    1685                 1690                 1695             


Glu Glu  Glu Ile Gln Val Ala  Asn Cys His Val Ala  Glu Asp Glu 
    1700                 1705                 1710             


Ser Arg  Ala Trp Asp Ser Leu  Asn Glu Ser Asn Lys  Phe Leu Val 
    1715                 1720                 1725             


Thr Ala  Asp Pro Lys Ser Glu  Asn Ile Tyr Asp Tyr  Leu Asp Ser 
    1730                 1735                 1740             


Ser Glu  Pro Ala Glu Asn Glu  Asn Lys Ser Asn Pro  Phe Cys Asp 
    1745                 1750                 1755             


Asn Gln  Gln Ser Ser Pro Asp  Pro Trp Thr Phe Ser  Pro Leu Thr 
    1760                 1765                 1770             


Glu Thr  Glu Met Gln Ile Thr  Ala Val Glu Lys Glu  Lys Arg Ser 
    1775                 1780                 1785             


Ser Pro  Glu Thr Gly Thr Thr  Gly Asp Val Ala Trp  Gln Ile Ser 
    1790                 1795                 1800             


Pro Lys  Ala Ser Phe Pro Lys  Asn Glu Asp Asn Ser  Gln Leu Glu 
    1805                 1810                 1815             


Met Leu  Gly Phe Ser Ala Asp  Ser Thr Glu Trp Trp  Lys Ala Ser 
    1820                 1825                 1830             


Pro Gln  Glu Gly Arg Leu Ile  Glu Ser Pro Phe Glu  Arg Glu Leu 
    1835                 1840                 1845             


Ser Asp  Ser Ser Gly Val Leu  Glu Ile Asn Ser Ser  Val His Gln 
    1850                 1855                 1860             


Asn Ala  Ser Pro Trp Gly Val  Pro Val Gln Gly Asp  Ile Glu Pro 
    1865                 1870                 1875             


Val Glu  Thr His Tyr Thr Asn  Pro Phe Ser Asp Asn  His Gln Ser 
    1880                 1885                 1890             


Pro Phe  Leu Glu Gly Asn Gly  Lys Asn Ser His Glu  Gln Leu Trp 
    1895                 1900                 1905             


Asn Ile  Gln Pro Arg Gln Pro  Asp Pro Asp Ala Asp  Lys Phe Ser 
    1910                 1915                 1920             


Gln Leu  Val Lys Leu Asp Gln  Ile Lys Glu Lys Asp  Ser Arg Glu 
    1925                 1930                 1935             


Gln Thr  Phe Val Ser Ala Ala  Gly Asp Glu Leu Thr  Pro Glu Thr 
    1940                 1945                 1950             


Pro Thr  Gln Glu Gln Cys Gln  Asp Thr Met Leu Pro  Val Cys Asp 
    1955                 1960                 1965             


His Pro  Asp Thr Ala Phe Thr  His Ala Glu Glu Asn  Ser Cys Val 
    1970                 1975                 1980             


Thr Ser  Asn Val Ser Thr Asn  Glu Gly Gln Glu Thr  Asn Gln Trp 
    1985                 1990                 1995             


Glu Gln  Glu Lys Ser Tyr Leu  Gly Glu Met Thr Asn  Ser Ser Ile 
    2000                 2005                 2010             


Ala Thr  Glu Asn Phe Pro Ala  Val Ser Ser Pro Thr  Gln Leu Ile 
    2015                 2020                 2025             


Met Lys  Pro Gly Ser Glu Trp  Asp Gly Ser Thr Pro  Ser Glu Asp 
    2030                 2035                 2040             


Ser Arg  Gly Thr Phe Val Pro  Asp Ile Leu His Gly  Asn Phe Gln 
    2045                 2050                 2055             


Glu Gly  Gly Gln Leu Ala Ser  Ala Ala Pro Asp Leu  Trp Ile Asp 
    2060                 2065                 2070             


Ala Lys  Lys Pro Phe Ser Leu  Lys Ala Asp Gly Glu  Asn Pro Asp 
    2075                 2080                 2085             


Ile Leu  Thr His Cys Glu His  Asp Ser Asn Ser Gln  Ala Ser Asp 
    2090                 2095                 2100             


Ser Pro  Asp Ile Cys His Asp  Ser Glu Ala Lys Gln  Glu Thr Glu 
    2105                 2110                 2115             


Lys His  Leu Ser Ala Cys Met  Gly Pro Glu Val Glu  Ser Ser Glu 
    2120                 2125                 2130             


Leu Cys  Leu Thr Glu Pro Glu  Ile Asp Glu Glu Pro  Ile Tyr Glu 
    2135                 2140                 2145             


Pro Gly  Arg Glu Phe Val Pro  Ser Asn Ala Glu Leu  Asp Ser Glu 
    2150                 2155                 2160             


Asn Ala  Thr Val Leu Pro Pro  Ile Gly Tyr Gln Ala  Asp Ile Lys 
    2165                 2170                 2175             


Gly Ser  Ser Gln Pro Ala Ser  His Lys Gly Ser Pro  Glu Pro Ser 
    2180                 2185                 2190             


Glu Ile  Asn Gly Asp Asn Ser  Thr Gly Leu Gln Val  Ser Glu Lys 
    2195                 2200                 2205             


Gly Ala  Ser Pro Asp Met Ala  Pro Ile Leu Glu Pro  Val Asp Arg 
    2210                 2215                 2220             


Arg Ile  Pro Arg Ile Glu Asn  Val Ala Thr Ser Ile  Phe Val Thr 
    2225                 2230                 2235             


His Gln  Glu Pro Thr Pro Glu  Gly Asp Gly Ser Trp  Ile Ser Asp 
    2240                 2245                 2250             


Ser Phe  Ser Pro Glu Ser Gln  Pro Gly Ala Arg Ala  Leu Phe Asp 
    2255                 2260                 2265             


Gly Asp  Pro His Leu Ser Thr  Glu Asn Pro Ala Leu  Val Pro Asp 
    2270                 2275                 2280             


Ala Leu  Leu Ala Ser Asp Thr  Cys Leu Asp Ile Ser  Glu Ala Ala 
    2285                 2290                 2295             


Phe Asp  His Ser Phe Ser Asp  Ala Ser Gly Leu Asn  Thr Ser Thr 
    2300                 2305                 2310             


Gly Thr  Ile Asp Asp Met Ser  Lys Leu Thr Leu Ser  Glu Gly His 
    2315                 2320                 2325             


Pro Glu  Thr Pro Val Asp Gly  Asp Leu Gly Lys Gln  Asp Ile Cys 
    2330                 2335                 2340             


Ser Ser  Glu Ala Ser Trp Gly  Asp Phe Glu Tyr Asp  Val Met Gly 
    2345                 2350                 2355             


Gln Asn  Ile Asp Glu Asp Leu  Leu Arg Glu Pro Glu  His Phe Leu 
    2360                 2365                 2370             


Tyr Gly  Gly Asp Pro Pro Leu  Glu Glu Asp Ser Leu  Lys Gln Ser 
    2375                 2380                 2385             


Leu Ala  Pro Tyr Thr Pro Pro  Phe Asp Leu Ser Tyr  Leu Thr Glu 
    2390                 2395                 2400             


Pro Ala  Gln Ser Ala Glu Thr  Ile Glu Glu Ala Gly  Ser Pro Glu 
    2405                 2410                 2415             


Asp Glu  Ser Leu Gly Cys Arg  Ala Ala Glu Ile Val  Leu Ser Ala 
    2420                 2425                 2430             


Leu Pro  Asp Arg Arg Ser Glu  Gly Asn Gln Ala Glu  Thr Lys Asn 
    2435                 2440                 2445             


Arg Leu  Pro Gly Ser Gln Leu  Ala Val Leu His Ile  Arg Glu Asp 
    2450                 2455                 2460             


Pro Glu  Ser Val Tyr Leu Pro  Val Gly Ala Gly Ser  Asn Ile Leu 
    2465                 2470                 2475             


Ser Pro  Ser Asn Val Asp Trp  Glu Val Glu Thr Asp  Asn Ser Asp 
    2480                 2485                 2490             


Leu Pro  Ala Gly Gly Asp Ile  Gly Pro Pro Asn Gly  Ala Ser Lys 
    2495                 2500                 2505             


Glu Ile  Ser Glu Leu Glu Glu  Glu Lys Thr Ile Pro  Thr Lys Glu 
    2510                 2515                 2520             


Pro Glu  Gln Ile Lys Ser Glu  Tyr Lys Glu Glu Arg  Cys Thr Glu 
    2525                 2530                 2535             


Lys Asn  Glu Asp Arg His Ala  Leu His Met Asp Tyr  Ile Leu Val 
    2540                 2545                 2550             


Asn Arg  Glu Glu Asn Ser His  Ser Lys Pro Glu Thr  Cys Glu Glu 
    2555                 2560                 2565             


Arg Glu  Ser Ile Ala Glu Leu  Glu Leu Tyr Val Gly  Ser Lys Glu 
    2570                 2575                 2580             


Thr Gly  Leu Gln Gly Thr Gln  Leu Ala Ser Phe Pro  Asp Thr Cys 
    2585                 2590                 2595             


Gln Pro  Ala Ser Leu Asn Glu  Arg Lys Gly Leu Ser  Ala Glu Lys 
    2600                 2605                 2610             


Met Ser  Ser Lys Ser Asp Thr  Arg Ser Ser Phe Glu  Ser Pro Ala 
    2615                 2620                 2625             


Gln Asp  Gln Ser Trp Met Phe  Leu Gly His Ser Glu  Val Gly Asp 
    2630                 2635                 2640             


Pro Ser  Leu Asp Ala Arg Asp  Ser Gly Pro Gly Trp  Ser Gly Lys 
    2645                 2650                 2655             


Thr Val  Glu Pro Phe Ser Glu  Leu Gly Leu Gly Glu  Gly Pro Gln 
    2660                 2665                 2670             


Leu Gln  Ile Leu Glu Glu Met  Lys Pro Leu Glu Ser  Leu Ala Leu 
    2675                 2680                 2685             


Glu Glu  Ala Ser Gly Pro Val  Ser Gln Ser Gln Lys  Ser Lys Ser 
    2690                 2695                 2700             


Arg Gly  Arg Ala Gly Pro Asp  Ala Val Thr Leu Gln  Ala Val Thr 
    2705                 2710                 2715             


His Asp  Asn Glu Trp Glu Met  Leu Ser Pro Gln Pro  Val Gln Lys 
    2720                 2725                 2730             


Asn Met  Ile Pro Asp Thr Glu  Met Glu Glu Glu Thr  Glu Phe Leu 
    2735                 2740                 2745             


Glu Leu  Gly Thr Arg Ile Ser  Arg Pro Asn Gly Leu  Leu Ser Glu 
    2750                 2755                 2760             


Asp Val  Gly Met Asp Ile Pro  Phe Glu Glu Gly Val  Leu Ser Pro 
    2765                 2770                 2775             


Ser Ala  Ala Asp Met Arg Pro  Glu Pro Pro Asn Ser  Leu Asp Leu 
    2780                 2785                 2790             


Asn Asp  Thr His Pro Arg Arg  Ile Lys Leu Thr Ala  Pro Asn Ile 
    2795                 2800                 2805             


Asn Leu  Ser Leu Asp Gln Ser  Glu Gly Ser Ile Leu  Ser Asp Asp 
    2810                 2815                 2820             


Asn Leu  Asp Ser Pro Asp Glu  Ile Asp Ile Asn Val  Asp Glu Leu 
    2825                 2830                 2835             


Asp Thr  Pro Asp Glu Ala Asp  Ser Phe Glu Tyr Thr  Gly His Asp 
    2840                 2845                 2850             


Pro Thr  Ala Asn Lys Asp Ser  Gly Gln Glu Ser Glu  Ser Ile Pro 
    2855                 2860                 2865             


Glu Tyr  Thr Ala Glu Glu Glu  Arg Glu Asp Asn Arg  Leu Trp Arg 
    2870                 2875                 2880             


Thr Val  Val Ile Gly Glu Gln  Glu Gln Arg Ile Asp  Met Lys Val 
    2885                 2890                 2895             


Ile Glu  Pro Tyr Arg Arg Val  Ile Ser His Gly Gly  Tyr Tyr Gly 
    2900                 2905                 2910             


Asp Gly  Leu Asn Ala Ile Ile  Val Phe Ala Ala Cys  Phe Leu Pro 
    2915                 2920                 2925             


Asp Ser  Ser Arg Ala Asp Tyr  His Tyr Val Met Glu  Asn Leu Phe 
    2930                 2935                 2940             


Leu Tyr  Val Ile Ser Thr Leu  Glu Leu Met Val Ala  Glu Asp Tyr 
    2945                 2950                 2955             


Met Ile  Val Tyr Leu Asn Gly  Ala Thr Pro Arg Arg  Arg Met Pro 
    2960                 2965                 2970             


Gly Leu  Gly Trp Met Lys Lys  Cys Tyr Gln Met Ile  Asp Arg Arg 
    2975                 2980                 2985             


Leu Arg  Lys Asn Leu Lys Ser  Phe Ile Ile Val His  Pro Ser Trp 
    2990                 2995                 3000             


Phe Ile  Arg Thr Ile Leu Ala  Val Thr Arg Pro Phe  Ile Ser Ser 
    3005                 3010                 3015             


Lys Phe  Ser Ser Lys Ile Lys  Tyr Val Asn Ser Leu  Ser Glu Leu 
    3020                 3025                 3030             


Ser Gly  Leu Ile Pro Met Asp  Cys Ile His Ile Pro  Glu Ser Ile 
    3035                 3040                 3045             


Ile Lys  Leu Asp Glu Glu Leu  Arg Glu Ala Ser Glu  Ala Ala Lys 
    3050                 3055                 3060             


Thr Ser  Cys Leu Tyr Asn Asp  Pro Glu Met Ser Ser  Met Glu Lys 
    3065                 3070                 3075             


Asp Ile  Asp Leu Lys Leu Lys  Glu Lys Pro 
    3080                 3085             


<210>  114
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Asp Thr Pro Arg Gly Ile Gly Thr Phe Val Val Trp Asp Tyr Val 
1               5                   10                  15      


Val Phe Ala Gly Met Leu Val Ile Ser Ala Ala Ile Gly Ile Tyr Tyr 
            20                  25                  30          


Ala Phe Ala Gly Gly Gly Gln Gln Thr Ser Lys Asp Phe Leu Met Gly 
        35                  40                  45              


Gly Arg Arg Met Thr Ala Val Pro Val Ala Leu Ser Leu Thr Ala Ser 
    50                  55                  60                  


Phe Met Ser Ala Val Thr Val Leu Gly Thr Pro Ser Glu Val Tyr Arg 
65                  70                  75                  80  


Phe Gly Ala Ile Phe Ser Ile Phe Ala Phe Thr Tyr Phe Phe Val Val 
                85                  90                  95      


Val Ile Ser Ala Glu Val Phe Leu Pro Val Phe Tyr Lys Leu Gly Ile 
            100                 105                 110         


Thr Ser Thr Tyr Glu Tyr Leu Glu Leu Arg Phe Asn Lys Cys Val Arg 
        115                 120                 125             


Leu Cys Gly Thr Val Leu Phe Ile Val Gln Thr Ile Leu Tyr Thr Gly 
    130                 135                 140                 


Ile Val Ile Tyr Ala Pro Ala Leu Ala Leu Asn Gln Val Thr Gly Phe 
145                 150                 155                 160 


Asp Leu Trp Gly Ala Val Val Ala Thr Gly Val Val Cys Thr Phe Tyr 
                165                 170                 175     


Cys Thr Leu Gly Gly Leu Lys Ala Val Ile Trp Thr Asp Val Phe Gln 
            180                 185                 190         


Val Gly Ile Met Val Ala Gly Phe Ala Ser Val Ile Ile Gln Ala Val 
        195                 200                 205             


Val Met Gln Gly Gly Ile Ser Thr Ile Leu Asn Asp Ala Tyr Asp Gly 
    210                 215                 220                 


Gly Arg Leu Asn Phe Trp Asn Phe Asn Pro Asn Pro Leu Gln Arg His 
225                 230                 235                 240 


Thr Phe Trp Thr Ile Ile Ile Gly Gly Thr Phe Thr Trp Thr Ser Ile 
                245                 250                 255     


Tyr Gly Val Asn Gln Ser Gln Val Gln Arg Tyr Ile Ser Cys Lys Ser 
            260                 265                 270         


Arg Phe Gln Ala Lys Leu Ser Leu Tyr Ile Asn Leu Val Gly Leu Trp 
        275                 280                 285             


Ala Ile Leu Thr Cys Ser Val Phe Cys Gly Leu Ala Leu Tyr Ser Arg 
    290                 295                 300                 


Tyr His Asp Cys Asp Pro Trp Thr Ala Lys Lys Val Ser Ala Pro Asp 
305                 310                 315                 320 


Gln Leu Met Pro Tyr Leu Val Leu Asp Ile Leu Gln Asp Tyr Pro Gly 
                325                 330                 335     


Leu Pro Gly Leu Phe Val Ala Cys Ala Tyr Ser Gly Thr Leu Ser Thr 
            340                 345                 350         


Val Ser Ser Ser Ile Asn Ala Leu Ala Ala Val Thr Val Glu Asp Leu 
        355                 360                 365             


Ile Lys Pro Tyr Phe Arg Ser Leu Ser Glu Arg Ser Leu Ser Trp Ile 
    370                 375                 380                 


Ser Gln Gly Met Ser Val Val Tyr Gly Ala Leu Cys Ile Gly Met Ala 
385                 390                 395                 400 


Ala Leu Ala Ser Leu Met Gly Ala Leu Leu Gln Ala Ala Leu Ser Val 
                405                 410                 415     


Phe Gly Met Val Gly Gly Pro Leu Met Gly Leu Phe Ala Leu Gly Ile 
            420                 425                 430         


Leu Val Pro Phe Ala Asn Ser Ile Gly Ala Leu Val Gly Leu Met Ala 
        435                 440                 445             


Gly Phe Ala Ile Ser Leu Trp Val Gly Ile Gly Ala Gln Ile Tyr Pro 
    450                 455                 460                 


Pro Leu Pro Glu Arg Thr Leu Pro Leu His Leu Asp Ile Gln Gly Cys 
465                 470                 475                 480 


Asn Ser Thr Tyr Asn Glu Thr Asn Leu Met Thr Thr Thr Glu Met Pro 
                485                 490                 495     


Phe Thr Thr Ser Val Phe Gln Ile Tyr Asn Val Gln Arg Thr Pro Leu 
            500                 505                 510         


Met Asp Asn Trp Tyr Ser Leu Ser Tyr Leu Tyr Phe Ser Thr Val Gly 
        515                 520                 525             


Thr Leu Val Thr Leu Leu Val Gly Ile Leu Val Ser Leu Ser Thr Gly 
    530                 535                 540                 


Gly Arg Lys Gln Asn Leu Asp Pro Arg Tyr Ile Leu Thr Lys Glu Asp 
545                 550                 555                 560 


Phe Leu Ser Asn Phe Asp Ile Phe Lys Lys Lys Lys His Val Leu Ser 
                565                 570                 575     


Tyr Lys Ser His Pro Val Glu Asp Gly Gly Thr Asp Asn Pro Ala Phe 
            580                 585                 590         


Asn His Ile Glu Leu Asn Ser Asp Gln Ser Gly Lys Ser Asn Gly Thr 
        595                 600                 605             


Arg Leu 
    610 


<210>  115
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Ser Gly Arg Arg Gly Trp Asp Ser Ser His Glu Asp Asp Leu 
1               5                   10                  15      


Pro Val Tyr Leu Ala Arg Pro Gly Thr Thr Asp Gln Val Pro Arg Gln 
            20                  25                  30          


Lys Tyr Gly Gly Met Phe Cys Asn Val Glu Gly Ala Phe Glu Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Asp Ala Leu Ser Val Gly Gln Arg Gly Ala Lys Thr 
    50                  55                  60                  


Pro Arg Ser Gly Gln Gly Ser Asp Arg Gly Ser Gly Ser Arg Pro Gly 
65                  70                  75                  80  


Ile Glu Gly Asp Thr Pro Arg Arg Gly Gln Gly Arg Glu Glu Ser Arg 
                85                  90                  95      


Glu Pro Ala Pro Ala Ser Pro Ala Pro Ala Gly Val Glu Ile Arg Ser 
            100                 105                 110         


Ala Thr Gly Lys Glu Val Leu Gln Asn Leu Gly Pro Lys Asp Lys Ser 
        115                 120                 125             


Asp Arg Leu Leu Ile Lys Gly Gly Arg Ile Val Asn Asp Asp Gln Ser 
    130                 135                 140                 


Phe Tyr Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly 
145                 150                 155                 160 


Asp Asn Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly 
                165                 170                 175     


Lys Met Val Ile Pro Gly Gly Ile Asp Val His Thr His Phe Gln Met 
            180                 185                 190         


Pro Tyr Lys Gly Met Thr Thr Val Asp Asp Phe Phe Gln Gly Thr Lys 
        195                 200                 205             


Ala Ala Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro 
    210                 215                 220                 


Glu Pro Glu Ser Ser Leu Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp 
225                 230                 235                 240 


Ala Asp Gly Lys Ser Cys Cys Asp Tyr Ala Leu His Val Asp Ile Thr 
                245                 250                 255     


His Trp Asn Asp Ser Val Lys Gln Glu Val Gln Asn Leu Ile Lys Asp 
            260                 265                 270         


Lys Gly Val Asn Ser Phe Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr 
        275                 280                 285             


Gln Val Ser Asn Thr Glu Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu 
    290                 295                 300                 


Leu Gly Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala 
305                 310                 315                 320 


Gln Glu Gln Thr Arg Met Leu Glu Met Gly Ile Thr Gly Pro Glu Gly 
                325                 330                 335     


His Val Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg 
            340                 345                 350         


Ala Ile Thr Ile Ala Ser Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys 
        355                 360                 365             


Val Met Ser Lys Ser Ala Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys 
    370                 375                 380                 


Gly Asn Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp 
385                 390                 395                 400 


Gly Thr His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val 
                405                 410                 415     


Thr Ser Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn 
            420                 425                 430         


Ser Leu Leu Ala Ser Gly Asp Leu Gln Leu Ser Gly Ser Ala His Cys 
        435                 440                 445             


Thr Phe Ser Thr Ala Gln Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala 
    450                 455                 460                 


Ile Pro Glu Gly Thr Asn Gly Val Glu Glu Arg Met Ser Val Ile Trp 
465                 470                 475                 480 


Asp Lys Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala 
                485                 490                 495     


Val Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys 
            500                 505                 510         


Gly Arg Ile Ser Val Gly Ser Asp Ser Asp Leu Val Ile Trp Asp Pro 
        515                 520                 525             


Asp Ala Val Lys Ile Val Ser Ala Lys Asn His Gln Ser Ala Ala Glu 
    530                 535                 540                 


Tyr Asn Ile Phe Glu Gly Met Glu Leu Arg Gly Ala Pro Leu Val Val 
545                 550                 555                 560 


Ile Cys Gln Gly Lys Ile Met Leu Glu Asp Gly Asn Leu His Val Thr 
                565                 570                 575     


Gln Gly Ala Gly Arg Phe Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val 
            580                 585                 590         


Tyr Lys Arg Ile Lys Ala Arg Arg Lys Met Ala Asp Leu His Ala Val 
        595                 600                 605             


Pro Arg Gly Met Tyr Asp Gly Pro Val Phe Asp Leu Thr Thr Thr Pro 
    610                 615                 620                 


Lys Gly Gly Thr Pro Ala Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro 
625                 630                 635                 640 


Asn Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly 
                645                 650                 655     


Thr Gln Val Asp Glu Gly Val Arg Ser Ala Ser Lys Arg Ile Val Ala 
            660                 665                 670         


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
        675                 680                 


<210>  116
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Ala Ala Gly Pro Arg Arg Ser Val Arg Gly Ala Val Cys Leu 
1               5                   10                  15      


His Leu Leu Leu Thr Leu Val Ile Phe Ser Arg Ala Gly Glu Ala Cys 
            20                  25                  30          


Lys Lys Val Ile Leu Asn Val Pro Ser Lys Leu Glu Ala Asp Lys Ile 
        35                  40                  45              


Ile Gly Arg Val Asn Leu Glu Glu Cys Phe Arg Ser Ala Asp Leu Ile 
    50                  55                  60                  


Arg Ser Ser Asp Pro Asp Phe Arg Val Leu Asn Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Ala Arg Ala Val Ala Leu Ser Asp Lys Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Trp Leu Ser Asp Lys Arg Lys Gln Thr Gln Lys Glu Val Thr Val Leu 
            100                 105                 110         


Leu Glu His Gln Lys Lys Val Ser Lys Thr Arg His Thr Arg Glu Thr 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Gln Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Glu 
145                 150                 155                 160 


Ser Asp Ala Ala Gln Asn Tyr Thr Val Phe Tyr Ser Ile Ser Gly Arg 
                165                 170                 175     


Gly Val Asp Lys Glu Pro Leu Asn Leu Phe Tyr Ile Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Phe Cys Thr Arg Pro Val Asp Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Phe Asp Leu Ile Ala Tyr Ala Ser Thr Ala Asp Gly Tyr Ser Ala Asp 
    210                 215                 220                 


Leu Pro Leu Pro Leu Pro Ile Arg Val Glu Asp Glu Asn Asp Asn His 
225                 230                 235                 240 


Pro Val Phe Thr Glu Ala Ile Tyr Asn Phe Glu Val Leu Glu Ser Ser 
                245                 250                 255     


Arg Pro Gly Thr Thr Val Gly Val Val Cys Ala Thr Asp Arg Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Leu Gln Gln Thr 
        275                 280                 285             


Pro Arg Ser Pro Gly Leu Phe Ser Val His Pro Ser Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Val Ser His Tyr Leu Asp Arg Glu Val Val Asp Lys Tyr Ser 
305                 310                 315                 320 


Leu Ile Met Lys Val Gln Asp Met Asp Gly Gln Phe Phe Gly Leu Ile 
                325                 330                 335     


Gly Thr Ser Thr Cys Ile Ile Thr Val Thr Asp Ser Asn Asp Asn Ala 
            340                 345                 350         


Pro Thr Phe Arg Gln Asn Ala Tyr Glu Ala Phe Val Glu Glu Asn Ala 
        355                 360                 365             


Phe Asn Val Glu Ile Leu Arg Ile Pro Ile Glu Asp Lys Asp Leu Ile 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Val Asn Phe Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly His Phe Lys Ile Ser Thr Asp Lys Glu Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Ser Val Val Lys Pro Leu Asn Tyr Glu Glu Asn Arg Gln Val Asn 
            420                 425                 430         


Leu Glu Ile Gly Val Asn Asn Glu Ala Pro Phe Ala Arg Asp Ile Pro 
        435                 440                 445             


Arg Val Thr Ala Leu Asn Arg Ala Leu Val Thr Val His Val Arg Asp 
    450                 455                 460                 


Leu Asp Glu Gly Pro Glu Cys Thr Pro Ala Ala Gln Tyr Val Arg Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Ala Val Gly Ser Lys Ile Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Asn Arg Asn Gly Asn Gly Leu Arg Tyr Lys Lys Leu His 
            500                 505                 510         


Asp Pro Lys Gly Trp Ile Thr Ile Asp Glu Ile Ser Gly Ser Ile Ile 
        515                 520                 525             


Thr Ser Lys Ile Leu Asp Arg Glu Val Glu Thr Pro Lys Asn Glu Leu 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ile Asp Lys Asp Asp Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Ala Val Asn Ile Glu Asp Val Asn Asp Asn Pro Pro Glu 
                565                 570                 575     


Ile Leu Gln Glu Tyr Val Val Ile Cys Lys Pro Lys Met Gly Tyr Thr 
            580                 585                 590         


Asp Ile Leu Ala Val Asp Pro Asp Glu Pro Val His Gly Ala Pro Phe 
        595                 600                 605             


Tyr Phe Ser Leu Pro Asn Thr Ser Pro Glu Ile Ser Arg Leu Trp Ser 
    610                 615                 620                 


Leu Thr Lys Val Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Lys Asn 
625                 630                 635                 640 


Ala Gly Phe Gln Glu Tyr Thr Ile Pro Ile Thr Val Lys Asp Arg Ala 
                645                 650                 655     


Gly Gln Ala Ala Thr Lys Leu Leu Arg Val Asn Leu Cys Glu Cys Thr 
            660                 665                 670         


His Pro Thr Gln Cys Arg Ala Thr Ser Arg Ser Thr Gly Val Ile Leu 
        675                 680                 685             


Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile Ala Leu Leu Phe 
    690                 695                 700                 


Ser Val Leu Leu Thr Leu Val Cys Gly Val Phe Gly Ala Thr Lys Gly 
705                 710                 715                 720 


Lys Arg Phe Pro Glu Asp Leu Ala Gln Gln Asn Leu Ile Ile Ser Asn 
                725                 730                 735     


Thr Glu Ala Pro Gly Asp Asp Arg Val Cys Ser Ala Asn Gly Phe Met 
            740                 745                 750         


Thr Gln Thr Thr Asn Asn Ser Ser Gln Gly Phe Cys Gly Thr Met Gly 
        755                 760                 765             


Ser Gly Met Lys Asn Gly Gly Gln Glu Thr Ile Glu Met Met Lys Gly 
    770                 775                 780                 


Gly Asn Gln Thr Leu Glu Ser Cys Arg Gly Ala Gly His His His Thr 
785                 790                 795                 800 


Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val Asp Asn Cys Arg Tyr 
                805                 810                 815     


Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro Arg Leu Gly Glu Glu 
            820                 825                 830         


Ser Ile Arg Gly His Thr Gly 
        835                 


<210>  117
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ser Ser Glu Ser Lys Glu Gln His Asn Val Ser Pro Arg Asp Ser 
1               5                   10                  15      


Ala Glu Gly Asn Asp Ser Tyr Pro Ser Gly Ile His Leu Glu Leu Gln 
            20                  25                  30          


Arg Glu Ser Ser Thr Asp Phe Lys Gln Phe Glu Thr Asn Asp Gln Cys 
        35                  40                  45              


Arg Pro Tyr His Arg Ile Leu Ile Glu Arg Gln Glu Lys Ser Asp Thr 
    50                  55                  60                  


Asn Phe Lys Glu Phe Val Ile Lys Lys Leu Gln Lys Asn Cys Gln Cys 
65                  70                  75                  80  


Ser Pro Ala Lys Ala Lys Asn Met Ile Leu Gly Phe Leu Pro Val Leu 
                85                  90                  95      


Gln Trp Leu Pro Lys Tyr Asp Leu Lys Lys Asn Ile Leu Gly Asp Val 
            100                 105                 110         


Met Ser Gly Leu Ile Val Gly Ile Leu Leu Val Pro Gln Ser Ile Ala 
        115                 120                 125             


Tyr Ser Leu Leu Ala Gly Gln Glu Pro Val Tyr Gly Leu Tyr Thr Ser 
    130                 135                 140                 


Phe Phe Ala Ser Ile Ile Tyr Phe Leu Leu Gly Thr Ser Arg His Ile 
145                 150                 155                 160 


Ser Val Gly Ile Phe Gly Val Leu Cys Leu Met Ile Gly Glu Thr Val 
                165                 170                 175     


Asp Arg Glu Leu Gln Lys Ala Gly Tyr Asp Asn Ala His Ser Ala Pro 
            180                 185                 190         


Ser Leu Gly Met Val Ser Asn Gly Ser Thr Leu Leu Asn His Thr Ser 
        195                 200                 205             


Asp Arg Ile Cys Asp Lys Ser Cys Tyr Ala Ile Met Val Gly Ser Thr 
    210                 215                 220                 


Val Thr Phe Ile Ala Gly Val Tyr Gln Val Ala Met Gly Phe Phe Gln 
225                 230                 235                 240 


Val Gly Phe Val Ser Val Tyr Leu Ser Asp Ala Leu Leu Ser Gly Phe 
                245                 250                 255     


Val Thr Gly Ala Ser Phe Thr Ile Leu Thr Ser Gln Ala Lys Tyr Leu 
            260                 265                 270         


Leu Gly Leu Asn Leu Pro Arg Thr Asn Gly Val Gly Ser Leu Ile Thr 
        275                 280                 285             


Thr Trp Ile His Val Phe Arg Asn Ile His Lys Thr Asn Leu Cys Asp 
    290                 295                 300                 


Leu Ile Thr Ser Leu Leu Cys Leu Leu Val Leu Leu Pro Thr Lys Glu 
305                 310                 315                 320 


Leu Asn Glu His Phe Lys Ser Lys Leu Lys Ala Pro Ile Pro Ile Glu 
                325                 330                 335     


Leu Val Val Val Val Ala Ala Thr Leu Ala Ser His Phe Gly Lys Leu 
            340                 345                 350         


His Glu Asn Tyr Asn Ser Ser Ile Ala Gly His Ile Pro Thr Gly Phe 
        355                 360                 365             


Met Pro Pro Lys Val Pro Glu Trp Asn Leu Ile Pro Ser Val Ala Val 
    370                 375                 380                 


Asp Ala Ile Ala Ile Ser Ile Ile Gly Phe Ala Ile Thr Val Ser Leu 
385                 390                 395                 400 


Ser Glu Met Phe Ala Lys Lys His Gly Tyr Thr Val Lys Ala Asn Gln 
                405                 410                 415     


Glu Met Tyr Ala Ile Gly Phe Cys Asn Ile Ile Pro Ser Phe Phe His 
            420                 425                 430         


Cys Phe Thr Thr Ser Ala Ala Leu Ala Lys Thr Leu Val Lys Glu Ser 
        435                 440                 445             


Thr Gly Cys His Thr Gln Leu Ser Gly Val Val Thr Ala Leu Val Leu 
    450                 455                 460                 


Leu Leu Val Leu Leu Val Ile Ala Pro Leu Phe Tyr Ser Leu Gln Lys 
465                 470                 475                 480 


Ser Val Leu Gly Val Ile Thr Ile Val Asn Leu Arg Gly Ala Leu Arg 
                485                 490                 495     


Lys Phe Arg Asp Leu Pro Lys Met Trp Ser Ile Ser Arg Met Asp Thr 
            500                 505                 510         


Val Ile Trp Phe Val Thr Met Leu Ser Ser Ala Leu Leu Ser Thr Glu 
        515                 520                 525             


Ile Gly Leu Leu Val Gly Val Cys Phe Ser Ile Phe Cys Val Ile Leu 
    530                 535                 540                 


Arg Thr Gln Lys Pro Lys Ser Ser Leu Leu Gly Leu Val Glu Glu Ser 
545                 550                 555                 560 


Glu Val Phe Glu Ser Val Ser Ala Tyr Lys Asn Leu Gln Ile Lys Pro 
                565                 570                 575     


Gly Ile Lys Ile Phe Arg Phe Val Ala Pro Leu Tyr Tyr Ile Asn Lys 
            580                 585                 590         


Glu Cys Phe Lys Ser Ala Leu Tyr Lys Gln Thr Val Asn Pro Ile Leu 
        595                 600                 605             


Ile Lys Val Ala Trp Lys Lys Ala Ala Lys Arg Lys Ile Lys Glu Lys 
    610                 615                 620                 


Val Val Thr Leu Gly Gly Ile Gln Asp Glu Met Ser Val Gln Leu Ser 
625                 630                 635                 640 


His Asp Pro Leu Glu Leu His Thr Ile Val Ile Asp Cys Ser Ala Ile 
                645                 650                 655     


Gln Phe Leu Asp Thr Ala Gly Ile His Thr Leu Lys Glu Val Arg Arg 
            660                 665                 670         


Asp Tyr Glu Ala Ile Gly Ile Gln Val Leu Leu Ala Gln Cys Asn Pro 
        675                 680                 685             


Thr Val Arg Asp Ser Leu Thr Asn Gly Glu Tyr Cys Lys Lys Glu Glu 
    690                 695                 700                 


Glu Asn Leu Leu Phe Tyr Ser Val Tyr Glu Ala Met Ala Phe Ala Glu 
705                 710                 715                 720 


Val Ser Lys Asn Gln Lys Gly Val Cys Val Pro Asn Gly Leu Ser Leu 
                725                 730                 735     


Ser Ser Asp 
            


<210>  118
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
1               5                   10                  15      


Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
            20                  25                  30          


Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
        35                  40                  45              


Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
    50                  55                  60                  


Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                85                  90                  95      


Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
            100                 105                 110         


Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
        115                 120                 125             


Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
    130                 135                 140                 


Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
145                 150                 155                 160 


Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                165                 170                 175     


Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
            180                 185                 190         


His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
        195                 200                 205             


Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Ala Thr His Leu His 
    210                 215                 220                 


Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
225                 230                 235                 240 


His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                245                 250                 255     


Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
            260                 265                 270         


Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
        275                 280                 285             


Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
    290                 295                 300                 


Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
305                 310                 315                 320 


Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                325                 330                 335     


Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
            340                 345                 350         


Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
        355                 360                 365             


Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
    370                 375                 380                 


<210>  119
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser 
1               5                   10                  15      


Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu 
            20                  25                  30          


Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln 
        35                  40                  45              


Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg 
    50                  55                  60                  


Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro 
65                  70                  75                  80  


Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly 
                85                  90                  95      


Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu 
            100                 105                 110         


Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp 
        115                 120                 125             


Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys 
    130                 135                 140                 


Glu Glu Lys Pro Ser Val Ser Lys Glu Glu Lys Pro Ser Val Ser Lys 
145                 150                 155                 160 


Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys 
                165                 170                 175     


Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg 
            180                 185                 190         


Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser 
        195                 200                 205             


Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu 
    210                 215                 220                 


Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly 
225                 230                 235                 240 


Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys 
                245                 250                 255     


Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp 
            260                 265                 270         


Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp 
        275                 280                 285             


Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu 
    290                 295                 300                 


Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp 
305                 310                 315                 320 


Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu 
                325                 330                 335     


Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu 
            340                 345                 350         


His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr 
        355                 360                 365             


Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly 
    370                 375                 380                 


Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg 
385                 390                 395                 400 


Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly 
                405                 410                 415     


Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys 
            420                 425                 430         


Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile 
        435                 440                 445             


Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu 
    450                 455                 460                 


Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala 
465                 470                 475                 480 


Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg 
                485                 490                 495     


Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly 
            500                 505                 510         


Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala 
        515                 520                 525             


Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser 
    530                 535                 540                 


Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp 
545                 550                 555                 560 


Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala 
                565                 570                 575     


Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly 
            580                 585                 590         


Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile 
        595                 600                 605             


Glu Gly Lys Lys Asn Ser Leu Arg Val Glu Gly Asp Asn Ile Tyr Val 
    610                 615                 620                 


Arg His Ser Asn Leu Met Leu Glu Glu Leu Asp Lys Ala Gln Glu Asp 
625                 630                 635                 640 


Ile Leu Lys His Gln Ala Ser Ile Ser Glu Leu Lys Arg Asn Phe Met 
                645                 650                 655     


Glu Ser Thr Pro Glu Pro Arg Pro Asn Glu Trp Glu Lys Arg Arg Ile 
            660                 665                 670         


Thr Pro Leu Ser Leu Gln Thr Gln Gly Ser Ser His Glu Thr Leu Asn 
        675                 680                 685             


Ile Val Glu Glu Lys Lys Arg Ala Glu Val Gly Lys Asp Glu Arg Val 
    690                 695                 700                 


Ile Thr Glu Glu Met Asn Gly Lys Glu Ile Ser Pro Gly Ser Gly Pro 
705                 710                 715                 720 


Gly Glu Ile Arg Lys Val Glu Pro Val Thr Gln Lys Asp Ser Thr Ser 
                725                 730                 735     


Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Glu Glu Glu Asp 
            740                 745                 750         


Val Gly Glu Tyr Arg Pro His His Arg Val Thr Glu Gly Thr Ile Arg 
        755                 760                 765             


Glu Glu Gln Glu Tyr Glu Glu Glu Val Glu Glu Glu Pro Arg Pro Ala 
    770                 775                 780                 


Ala Lys Val Val Glu Arg Glu Glu Ala Val Pro Glu Ala Ser Pro Val 
785                 790                 795                 800 


Thr Gln Ala Gly Ala Ser Val Ile Thr Val Glu Thr Val Ile Gln Glu 
                805                 810                 815     


Asn Val Gly Ala Gln Lys Ile Pro Gly Glu Lys Ser Val His Glu Gly 
            820                 825                 830         


Ala Leu Lys Gln Asp Met Gly Glu Glu Ala Glu Glu Glu Pro Gln Lys 
        835                 840                 845             


Val Asn Gly Glu Val Ser His Val Asp Ile Asp Val Leu Pro Gln Ile 
    850                 855                 860                 


Ile Cys Cys Ser Glu Pro Pro Val Val Lys Thr Glu Met Val Thr Ile 
865                 870                 875                 880 


Ser Asp Ala Ser Gln Arg Thr Glu Ile Ser Thr Lys Glu Val Pro Ile 
                885                 890                 895     


Val Gln Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Pro Gln Ile Asp 
            900                 905                 910         


Gly Gly Ala Gly Gly Asp Ser Gly Thr Leu Leu Thr Ala Gln Thr Ile 
        915                 920                 925             


Thr Ser Glu Ser Val Ser Thr Thr Thr Thr Thr His Ile Thr Lys Thr 
    930                 935                 940                 


Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile 
945                 950                 955                 960 


Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala Ile 
                965                 970                 975     


Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val Thr Arg Val Val 
            980                 985                 990         


Val His Lys Glu Thr Glu Leu Ala  Glu Glu Gly Glu Asp  
        995                 1000                 1005 


<210>  120
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Leu Val Leu His Asn Ser Gln Lys Leu Gln Ile Leu Tyr Lys Ser 
1               5                   10                  15      


Leu Glu Lys Ser Ile Pro Glu Ser Ile Lys Val Tyr Gly Ala Ile Phe 
            20                  25                  30          


Asn Ile Lys Asp Lys Asn Pro Phe Asn Met Glu Val Leu Val Asp Ala 
        35                  40                  45              


Trp Pro Asp Tyr Gln Ile Val Ile Thr Arg Pro Gln Lys Gln Glu Met 
    50                  55                  60                  


Lys Asp Asp Gln Asp His Tyr Thr Asn Thr Tyr His Ile Phe Thr Lys 
65                  70                  75                  80  


Ala Pro Asp Lys Leu Glu Glu Val Leu Ser Tyr Ser Asn Val Ile Ser 
                85                  90                  95      


Trp Glu Gln Thr Leu Gln Ile Gln Gly Cys Gln Glu Gly Leu Asp Glu 
            100                 105                 110         


Ala Ile Arg Lys Val Ala Thr Ser Lys Ser Val Gln Val Asp Tyr Met 
        115                 120                 125             


Lys Thr Ile Leu Phe Ile Pro Glu Leu Pro Lys Lys His Lys Thr Ser 
    130                 135                 140                 


Ser Asn Asp Lys Met Glu Leu Phe Glu Val Asp Asp Asp Asn Lys Glu 
145                 150                 155                 160 


Gly Asn Phe Ser Asn Met Phe Leu Asp Ala Ser His Ala Gly Leu Val 
                165                 170                 175     


Asn Glu His Trp Ala Phe Gly Lys Asn Glu Arg Ser Leu Lys Tyr Ile 
            180                 185                 190         


Glu Arg Cys Leu Gln Asp Phe Leu Gly Phe Gly Val Leu Gly Pro Glu 
        195                 200                 205             


Gly Gln Leu Val Ser Trp Ile Val Met Glu Gln Ser Cys Glu Leu Arg 
    210                 215                 220                 


Met Gly Tyr Thr Val Pro Lys Tyr Arg His Gln Gly Asn Met Leu Gln 
225                 230                 235                 240 


Ile Gly Tyr His Leu Glu Lys Tyr Leu Ser Gln Lys Glu Ile Pro Phe 
                245                 250                 255     


Tyr Phe His Val Ala Asp Asn Asn Glu Lys Ser Leu Gln Ala Leu Asn 
            260                 265                 270         


Asn Leu Gly Phe Lys Ile Cys Pro Cys Gly Trp His Gln Trp Lys Cys 
        275                 280                 285             


Thr Pro Lys Lys Tyr Cys 
    290                 


<210>  121
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gln Lys Pro Pro Leu Leu Leu Arg Arg Pro Leu Pro Pro Lys Phe 
1               5                   10                  15      


Thr Lys Leu Ser Leu His Glu Lys Lys Thr His Thr Ala Lys Thr Gly 
            20                  25                  30          


Lys Ile Glu Ser Leu His Val Ala Phe Thr Glu Asp Glu Thr Thr Ser 
        35                  40                  45              


Ile Lys Met Asp Arg Thr Arg Phe Pro Asp Val Leu Arg Asn Gln Ser 
    50                  55                  60                  


Leu Thr Pro Ile Asn Ile Gln Asn Ile Phe Leu Asp His Cys Val Gln 
65                  70                  75                  80  


Glu Arg Val Thr Ala Ile Ser Ser Pro Gln Lys Ser Thr Lys His Val 
                85                  90                  95      


Arg Glu Gln Ile Pro Asp Thr Ala Thr Gly Ser Ile Phe Phe Pro His 
            100                 105                 110         


Cys Asn Ser Ala Ser Thr Arg Ile Phe Gly Lys Gln Thr Asn Lys Met 
        115                 120                 125             


Glu Ser Ser Arg Lys Phe Lys Thr Met Lys Asp Val Tyr Thr Glu Lys 
    130                 135                 140                 


Arg Leu Glu Asn Ile Leu Ile Leu Ser Ser Lys Phe Ser Lys Pro Lys 
145                 150                 155                 160 


Ser Thr Pro Gly Ser Val Ile Ala Gln Lys Leu Glu Lys Met His Pro 
                165                 170                 175     


Lys His Gln Pro Leu Pro Glu Ser Pro Gly Tyr Thr Tyr Gln His Ile 
            180                 185                 190         


Ser Arg Asp Leu Ser Ala Thr Val Pro Ser Pro Pro Pro Met Thr Val 
        195                 200                 205             


Ser Met Lys Pro Glu Gly Gln Trp Pro Glu His Phe Lys Ser Thr Ala 
    210                 215                 220                 


Thr Leu Thr Leu Arg Val Thr Glu Phe Pro Gly Phe Val Ser Leu Pro 
225                 230                 235                 240 


Thr Pro Val Leu Pro Arg Lys Pro His Arg Gln Ser Val Ile Glu Thr 
                245                 250                 255     


Leu Val Thr Glu Asn Gly Asn Ile Glu Ser Val Pro Lys Gln Ile Pro 
            260                 265                 270         


Pro Arg Pro Pro Glu Gly Leu Thr Lys Thr Glu Lys Ile Glu Ser Glu 
        275                 280                 285             


Ile His Val Val Arg Gly Glu Gly Phe Lys Thr Val Ala Ala Thr Arg 
    290                 295                 300                 


Tyr Glu Thr Ile Thr Ala Met Thr Asn Leu Ala Ile Val Asn Cys Gln 
305                 310                 315                 320 


Val Tyr Gly Arg Asn Ala Leu Asn Leu Lys Gly Phe Phe Ile Leu Asn 
                325                 330                 335     


Cys Pro Asp Leu Thr Pro Leu Ala Phe Gln Leu Ile Tyr Leu Asn Leu 
            340                 345                 350         


Ser Phe Asn Asp Leu His Tyr Phe Pro Thr Glu Ile Leu Cys Leu Lys 
        355                 360                 365             


Asn Leu Gln Ile Leu Lys Leu Arg Asn Asn Pro Ile Lys Glu Ile Pro 
    370                 375                 380                 


Ser Glu Ile Gln Gln Leu Glu Phe Leu Arg Ile Phe Thr Ile Ala Phe 
385                 390                 395                 400 


Asn Leu Ile Thr Val Leu Pro Ile Gly Leu Phe Ser Leu Ser Tyr Leu 
                405                 410                 415     


Glu Glu Leu Asp Val Ser Tyr Asn Glu Leu Thr Phe Ile Pro Asn Glu 
            420                 425                 430         


Ile Gln Lys Leu Arg Ser Leu Glu Lys Leu Thr Val Asp Gly Asn Glu 
        435                 440                 445             


Leu Ser Phe Phe Pro His Gly Ile Leu Lys Leu Asn Leu Thr Lys Ile 
    450                 455                 460                 


Gln Phe Glu Asn Asn Phe Thr His Pro Cys Phe Trp Arg Asp Asn Tyr 
465                 470                 475                 480 


Leu Asn Asn Pro Gln Gln Leu Thr Gln Ile Ile Ser Leu Phe Ile Val 
                485                 490                 495     


Gln Asn Lys Leu His Lys Phe Tyr Asp Lys Ile Pro Val Glu Val Gln 
            500                 505                 510         


Lys Leu Leu Lys Trp 
        515         


<210>  122
<211>  1346
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  123
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu Ile Asn Asn Leu 
1               5                   10                  15      


Arg Glu Lys Val Met Lys Gln Ser Glu Glu Asn Asn Asn Leu Gln Ser 
            20                  25                  30          


Gln Val Gln Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gln Val 
        35                  40                  45              


Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu Arg Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Pro Pro Pro Pro Ile Glu Glu Glu Cys Pro Glu 
65                  70                  75                  80  


Asp Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro Phe 
                85                  90                  95      


Met Ala Gln Cys Gln Ile Phe Met Glu Lys Ser Thr Arg Asp Phe Ser 
            100                 105                 110         


Val Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly Arg 
        115                 120                 125             


Ala Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu Met 
    130                 135                 140                 


His Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu Asp 
145                 150                 155                 160 


Pro Gln Arg Arg Glu Val Ala Lys Arg Lys Ile Arg Arg Leu Arg Gln 
                165                 170                 175     


Gly Met Gly Ser Val Ile Asp Tyr Ser Asn Ala Phe Gln Met Ile Ala 
            180                 185                 190         


Gln Asp Leu Asp Trp Asn Glu Pro Ala Leu Ile Asp Gln Tyr His Glu 
        195                 200                 205             


Gly Leu Ser Asp His Ile Gln Glu Glu Leu Ser His Leu Glu Val Ala 
    210                 215                 220                 


Lys Ser Leu Ser Ala Leu Ile Gly Gln Cys Ile His Ile Glu Arg Arg 
225                 230                 235                 240 


Leu Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg Ala 
                245                 250                 255     


Leu Val Leu Pro His Ile Ala Ser His His Gln Val Asp Pro Thr Glu 
            260                 265                 270         


Pro Val Gly Gly Ala Arg Met Arg Leu Thr Gln Glu Glu Lys Glu Arg 
        275                 280                 285             


Arg Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His Tyr 
    290                 295                 300                 


Ala Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly Lys 
305                 310                 315                 320 


Leu Pro Gly Pro Ala Val Glu Gly Pro Ser Ala Thr Gly Pro Glu Ile 
                325                 330                 335     


Ile Arg Ser Pro Gln Asp Asp Ala Ser Ser Pro His Leu Gln Val Met 
            340                 345                 350         


Leu Gln Ile His Leu Pro Gly Arg His Thr Leu Phe Val Arg Ala Met 
        355                 360                 365             


Ile Asp Ser Gly Ala Ser Gly Asn Phe Ile Asp His Glu Tyr Val Ala 
    370                 375                 380                 


Gln Asn Gly Ile Pro Leu Arg Ile Lys Asp Trp Pro Ile Leu Val Glu 
385                 390                 395                 400 


Ala Ile Asp Gly Arg Pro Ile Ala Ser Gly Pro Val Val His Glu Thr 
                405                 410                 415     


His Asp Leu Ile Val Asp Leu Gly Asp His Arg Glu Val Leu Ser Phe 
            420                 425                 430         


Asp Val Thr Gln Ser Pro Phe Phe Pro Val Val Leu Gly Val Arg Trp 
        435                 440                 445             


Leu Ser Thr His Asp Pro Asn Ile Thr Trp Ser Thr Arg Ser Ile Val 
    450                 455                 460                 


Phe Asp Ser Glu Tyr Cys Arg Tyr His Cys Arg Met Tyr Ser Pro Ile 
465                 470                 475                 480 


Pro Pro Ser Leu Pro Pro Pro Ala Pro Gln Pro Pro Leu Tyr Tyr Pro 
                485                 490                 495     


Val Asp Gly Tyr Arg Val Tyr Gln Pro Val Arg Tyr Tyr Tyr Val Gln 
            500                 505                 510         


Asn Val Tyr Thr Pro Val Asp Glu His Val Tyr Pro Asp His Arg Leu 
        515                 520                 525             


Val Asp Pro His Ile Glu Met Ile Pro Gly Ala His Ser Ile Pro Ser 
    530                 535                 540                 


Gly His Val Tyr Ser Leu Ser Glu Pro Glu Met Ala Ala Leu Arg Asp 
545                 550                 555                 560 


Phe Val Ala Arg Asn Val Lys Asp Gly Leu Ile Thr Pro Thr Ile Ala 
                565                 570                 575     


Pro Asn Gly Ala Gln Val Leu Gln Val Lys Arg Gly Trp Lys Leu Gln 
            580                 585                 590         


Val Ser Tyr Asp Cys Arg Ala Pro Asn Asn Phe Thr Ile Gln Asn Gln 
        595                 600                 605             


Tyr Pro Arg Leu Ser Ile Pro Asn Leu Glu Asp Gln Ala His Leu Ala 
    610                 615                 620                 


Thr Tyr Thr Glu Phe Val Pro Gln Ile Pro Gly Tyr Gln Thr Tyr Pro 
625                 630                 635                 640 


Thr Tyr Ala Ala Tyr Pro Thr Tyr Pro Val Gly Phe Ala Trp Tyr Pro 
                645                 650                 655     


Val Gly Arg Asp Gly Gln Gly Arg Ser Leu Tyr Val Pro Val Met Ile 
            660                 665                 670         


Thr Trp Asn Pro His Trp Tyr Arg Gln Pro Pro Val Pro Gln Tyr Pro 
        675                 680                 685             


Pro Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    690                 695                 700                 


Tyr Ser Thr Leu 
705             


<210>  124
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Leu Ser Val Asp Ser Ser Trp His Arg Trp Gln Trp Arg Val 
1               5                   10                  15      


Arg Asp Gly Phe Pro His Cys Pro Ser Glu Thr Thr Pro Leu Leu Ser 
            20                  25                  30          


Pro Glu Lys Gly Arg Gln Ser Tyr Asn Leu Thr Gln Gln Arg Val Val 
        35                  40                  45              


Phe Pro Asn Asn Ser Ile Phe His Gln Asp Trp Glu Glu Val Ser Arg 
    50                  55                  60                  


Arg Tyr Pro Gly Asn Arg Thr Cys Thr Thr Lys Tyr Thr Leu Phe Thr 
65                  70                  75                  80  


Phe Leu Pro Arg Asn Leu Phe Glu Gln Phe His Arg Trp Ala Asn Leu 
                85                  90                  95      


Tyr Phe Leu Phe Leu Val Ile Leu Asn Trp Met Pro Ser Met Glu Val 
            100                 105                 110         


Phe His Arg Glu Ile Thr Met Leu Pro Leu Ala Ile Val Leu Phe Val 
        115                 120                 125             


Ile Met Ile Lys Asp Gly Met Glu Asp Phe Lys Arg His Arg Phe Asp 
    130                 135                 140                 


Lys Ala Ile Asn Cys Ser Asn Ile Arg Ile Tyr Glu Arg Lys Glu Gln 
145                 150                 155                 160 


Thr Tyr Val Gln Lys Cys Trp Lys Asp Val Arg Val Gly Asp Phe Ile 
                165                 170                 175     


Gln Met Lys Cys Asn Glu Ile Val Pro Ala Asp Ile Leu Leu Leu Phe 
            180                 185                 190         


Ser Ser Asp Pro Asn Gly Ile Cys His Leu Glu Thr Ala Ser Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Gln Arg Cys Val Val Lys Gly Phe Ser Gln 
    210                 215                 220                 


Gln Glu Val Gln Phe Glu Pro Glu Leu Phe His Asn Thr Ile Val Cys 
225                 230                 235                 240 


Glu Lys Pro Asn Asn His Leu Asn Lys Phe Lys Gly Tyr Met Glu His 
                245                 250                 255     


Pro Asp Gln Thr Arg Thr Gly Phe Gly Cys Glu Ser Leu Leu Leu Arg 
            260                 265                 270         


Gly Cys Thr Ile Arg Asn Thr Glu Met Ala Val Gly Ile Val Ile Tyr 
        275                 280                 285             


Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn Ser Gly Pro Arg Tyr 
    290                 295                 300                 


Lys Arg Ser Lys Ile Glu Arg Arg Met Asn Ile Asp Ile Phe Phe Cys 
305                 310                 315                 320 


Ile Gly Ile Leu Ile Leu Met Cys Leu Ile Gly Ala Val Gly His Ser 
                325                 330                 335     


Ile Trp Asn Gly Thr Phe Glu Glu His Pro Pro Phe Asp Val Pro Asp 
            340                 345                 350         


Ala Asn Gly Ser Phe Leu Pro Ser Ala Leu Gly Gly Phe Tyr Met Phe 
        355                 360                 365             


Leu Thr Met Ile Ile Leu Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr 
    370                 375                 380                 


Val Ser Ile Glu Leu Val Lys Leu Gly Gln Val Phe Phe Leu Ser Asn 
385                 390                 395                 400 


Asp Leu Asp Leu Tyr Asp Glu Glu Thr Asp Leu Ser Ile Gln Cys Arg 
                405                 410                 415     


Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser 
            420                 425                 430         


Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met Val Phe Arg Arg Cys 
        435                 440                 445             


Thr Ile Met Gly Ser Glu Tyr Ser His Gln Glu Asn Ala Lys Arg Leu 
    450                 455                 460                 


Glu Thr Pro Lys Glu Leu Asp Ser Asp Gly Glu Glu Trp Thr Gln Tyr 
465                 470                 475                 480 


Gln Cys Leu Ser Phe Ser Ala Arg Trp Ala Gln Asp Pro Ala Thr Met 
                485                 490                 495     


Arg Ser Gln Lys Gly Ala Gln Pro Leu Arg Arg Ser Gln Ser Ala Arg 
            500                 505                 510         


Val Pro Ile Gln Gly His Tyr Arg Gln Arg Ser Met Gly His Arg Glu 
        515                 520                 525             


Ser Ser Gln Pro Pro Val Ala Phe Ser Ser Ser Ile Glu Lys Asp Val 
    530                 535                 540                 


Thr Pro Asp Lys Asn Leu Leu Thr Lys Val Arg Asp Ala Ala Leu Trp 
545                 550                 555                 560 


Leu Glu Thr Leu Ser Asp Ser Arg Pro Ala Lys Ala Ser Leu Ser Thr 
                565                 570                 575     


Thr Ser Ser Ile Ala Asp Phe Phe Leu Ala Leu Thr Ile Cys Asn Ser 
            580                 585                 590         


Val Met Val Ser Thr Thr Thr Glu Pro Arg Gln Arg Val Thr Ile Lys 
        595                 600                 605             


Pro Ser Ser Lys Ala Leu Gly Thr Ser Leu Glu Lys Ile Gln Gln Leu 
    610                 615                 620                 


Phe Gln Lys Leu Lys Leu Leu Ser Leu Ser Gln Ser Phe Ser Ser Thr 
625                 630                 635                 640 


Ala Pro Ser Asp Thr Asp Leu Gly Glu Ser Leu Gly Ala Asn Val Ala 
                645                 650                 655     


Thr Thr Asp Ser Asp Glu Arg Asp Asp Ala Ser Val Cys Ser Gly Gly 
            660                 665                 670         


Asp Ser Thr Asp Asp Gly Gly Tyr Arg Ser Ser Met Trp Asp Gln Gly 
        675                 680                 685             


Asp Ile Leu Glu Ser Gly Ser Gly Thr Ser Leu Glu Glu Ala Leu Glu 
    690                 695                 700                 


Ala Pro Ala Thr Asp Leu Ala Arg Pro Glu Phe Cys Tyr Glu Ala Glu 
705                 710                 715                 720 


Ser Pro Asp Glu Ala Ala Leu Val His Ala Ala His Ala Tyr Ser Phe 
                725                 730                 735     


Thr Leu Val Ser Arg Thr Pro Glu Gln Val Thr Val Arg Leu Pro Gln 
            740                 745                 750         


Gly Thr Cys Leu Thr Phe Ser Leu Leu Cys Thr Leu Gly Phe Asp Ser 
        755                 760                 765             


Val Arg Lys Arg Met Ser Val Val Val Arg His Pro Leu Thr Gly Glu 
    770                 775                 780                 


Ile Val Val Tyr Thr Lys Gly Ala Asp Ser Val Ile Met Asp Leu Leu 
785                 790                 795                 800 


Glu Asp Pro Ala Cys Val Pro Asp Ile Asn Met Glu Lys Lys Leu Arg 
                805                 810                 815     


Lys Ile Arg Ala Arg Thr Gln Lys His Leu Asp Leu Tyr Ala Arg Asp 
            820                 825                 830         


Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Val Ser Glu Glu Asp 
        835                 840                 845             


Phe Arg Arg Trp Ala Ser Phe Arg Arg Glu Ala Glu Ala Ser Leu Asp 
    850                 855                 860                 


Asn Arg Asp Glu Leu Leu Met Glu Thr Ala Gln His Leu Glu Asn Gln 
865                 870                 875                 880 


Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu Gly 
                885                 890                 895     


Val Pro Asp Thr Ile Ala Thr Leu Arg Glu Ala Gly Ile Gln Leu Trp 
            900                 905                 910         


Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala His Ser 
        915                 920                 925             


Cys Arg Leu Leu Asn Gln Thr Asp Thr Val Tyr Thr Ile Asn Thr Glu 
    930                 935                 940                 


Asn Gln Glu Thr Cys Glu Ser Ile Leu Asn Cys Ala Leu Glu Glu Leu 
945                 950                 955                 960 


Lys Gln Phe Arg Glu Leu Gln Lys Pro Asp Arg Lys Leu Phe Gly Phe 
                965                 970                 975     


Arg Leu Pro Ser Lys Thr Pro Ser Ile Thr Ser Glu Ala Val Val Pro 
            980                 985                 990         


Glu Ala Gly Leu Val Ile Asp Gly  Lys Thr Leu Asn Ala  Ile Phe Gln 
        995                 1000                 1005             


Gly Lys  Leu Glu Lys Lys Phe  Leu Glu Leu Thr Gln  Tyr Cys Arg 
    1010                 1015                 1020             


Ser Val  Leu Cys Cys Arg Ser  Thr Pro Leu Gln Lys  Ser Met Ile 
    1025                 1030                 1035             


Val Lys  Leu Val Arg Asp Lys  Leu Arg Val Met Thr  Leu Ser Ile 
    1040                 1045                 1050             


Gly Asp  Gly Ala Asn Asp Val  Ser Met Ile Gln Ala  Ala Asp Ile 
    1055                 1060                 1065             


Gly Ile  Gly Ile Ser Gly Gln  Glu Gly Met Gln Ala  Val Met Ser 
    1070                 1075                 1080             


Ser Asp  Phe Ala Ile Thr Arg  Phe Lys His Leu Lys  Lys Leu Leu 
    1085                 1090                 1095             


Leu Val  His Gly His Trp Cys  Tyr Ser Arg Leu Ala  Arg Met Val 
    1100                 1105                 1110             


Val Tyr  Tyr Leu Tyr Lys Asn  Val Cys Tyr Val Asn  Leu Leu Phe 
    1115                 1120                 1125             


Trp Tyr  Gln Phe Phe Cys Gly  Phe Ser Ser Ser Thr  Met Ile Asp 
    1130                 1135                 1140             


Tyr Trp  Gln Met Ile Phe Phe  Asn Leu Phe Phe Thr  Ser Leu Pro 
    1145                 1150                 1155             


Pro Leu  Val Phe Gly Val Leu  Asp Lys Asp Ile Ser  Ala Glu Thr 
    1160                 1165                 1170             


Leu Leu  Ala Leu Pro Glu Leu  Tyr Lys Ser Gly Gln  Asn Ser Glu 
    1175                 1180                 1185             


Cys Tyr  Asn Leu Ser Thr Phe  Trp Ile Ser Met Val  Asp Ala Phe 
    1190                 1195                 1200             


Tyr Gln  Ser Leu Ile Cys Phe  Phe Ile Pro Tyr Leu  Ala Tyr Lys 
    1205                 1210                 1215             


Gly Ser  Asp Ile Asp Val Phe  Thr Phe Gly Thr Pro  Ile Asn Thr 
    1220                 1225                 1230             


Ile Ser  Leu Thr Thr Ile Leu  Leu His Gln Ala Met  Glu Met Lys 
    1235                 1240                 1245             


Thr Trp  Thr Ile Phe His Gly  Val Val Leu Leu Gly  Ser Phe Leu 
    1250                 1255                 1260             


Met Tyr  Phe Leu Val Ser Leu  Leu Tyr Asn Ala Thr  Cys Val Ile 
    1265                 1270                 1275             


Cys Asn  Ser Pro Thr Asn Pro  Tyr Trp Val Met Glu  Gly Gln Leu 
    1280                 1285                 1290             


Ser Asn  Pro Thr Phe Tyr Leu  Val Cys Phe Leu Thr  Pro Val Val 
    1295                 1300                 1305             


Ala Leu  Leu Pro Arg Tyr Phe  Phe Leu Ser Leu Gln  Gly Thr Cys 
    1310                 1315                 1320             


Gly Lys  Ser Leu Ile Ser Lys  Ala Gln Lys Ile Asp  Lys Leu Pro 
    1325                 1330                 1335             


Pro Asp  Lys Arg Asn Leu Glu  Ile Gln Ser Trp Arg  Ser Arg Gln 
    1340                 1345                 1350             


Arg Pro  Ala Pro Val Pro Glu  Val Ala Arg Pro Thr  His His Pro 
    1355                 1360                 1365             


Val Ser  Ser Ile Thr Gly Gln  Asp Phe Ser Ala Ser  Thr Pro Lys 
    1370                 1375                 1380             


Ser Ser  Asn Pro Pro Lys Arg  Lys His Val Glu Glu  Ser Val Leu 
    1385                 1390                 1395             


His Glu  Gln Arg Cys Gly Thr  Glu Cys Met Arg Asp  Asp Ser Cys 
    1400                 1405                 1410             


Ser Gly  Asp Ser Ser Ala Gln  Leu Ser Ser Gly Glu  His Leu Leu 
    1415                 1420                 1425             


Gly Pro  Asn Arg Ile Met Ala  Tyr Ser Arg Gly Gln  Thr Asp Met 
    1430                 1435                 1440             


Cys Arg  Cys Ser Lys Arg Ser  Ser His Arg Arg Ser  Gln Ser Ser 
    1445                 1450                 1455             


Leu Thr  Ile 
    1460     


<210>  125
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  126
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  127
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Gly Pro Leu Lys Ala Phe Leu Phe Ser Pro Phe Leu Leu Arg Ser 
1               5                   10                  15      


Gln Ser Arg Gly Val Arg Leu Val Phe Leu Leu Leu Thr Leu His Leu 
            20                  25                  30          


Gly Asn Cys Val Asp Lys Ala Asp Asp Glu Asp Asp Glu Asp Leu Thr 
        35                  40                  45              


Val Asn Lys Thr Trp Val Leu Ala Pro Lys Ile His Glu Gly Asp Ile 
    50                  55                  60                  


Thr Gln Ile Leu Asn Ser Leu Leu Gln Gly Tyr Asp Asn Lys Leu Arg 
65                  70                  75                  80  


Pro Asp Ile Gly Val Arg Pro Thr Val Ile Glu Thr Asp Val Tyr Val 
                85                  90                  95      


Asn Ser Ile Gly Pro Val Asp Pro Ile Asn Met Glu Tyr Thr Ile Asp 
            100                 105                 110         


Ile Ile Phe Ala Gln Thr Trp Phe Asp Ser Arg Leu Lys Phe Asn Ser 
        115                 120                 125             


Thr Met Lys Val Leu Met Leu Asn Ser Asn Met Val Gly Lys Ile Trp 
    130                 135                 140                 


Ile Pro Asp Thr Phe Phe Arg Asn Ser Arg Lys Ser Asp Ala His Trp 
145                 150                 155                 160 


Ile Thr Thr Pro Asn Arg Leu Leu Arg Ile Trp Asn Asp Gly Arg Val 
                165                 170                 175     


Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Tyr Leu Gln Leu 
            180                 185                 190         


His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe Ser Ser 
        195                 200                 205             


Tyr Gly Tyr Pro Lys Asn Glu Ile Glu Tyr Lys Trp Lys Lys Pro Ser 
    210                 215                 220                 


Val Glu Val Ala Asp Pro Lys Tyr Trp Arg Leu Tyr Gln Phe Ala Phe 
225                 230                 235                 240 


Val Gly Leu Arg Asn Ser Thr Glu Ile Thr His Thr Ile Ser Gly Asp 
                245                 250                 255     


Tyr Val Ile Met Thr Ile Phe Phe Asp Leu Ser Arg Arg Met Gly Tyr 
            260                 265                 270         


Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser 
        275                 280                 285             


Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg Thr Ser 
    290                 295                 300                 


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala 
305                 310                 315                 320 


Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp Leu Phe 
                325                 330                 335     


Val Ser Val Cys Phe Ile Phe Val Phe Ala Ala Leu Met Glu Tyr Gly 
            340                 345                 350         


Thr Leu His Tyr Phe Thr Ser Asn Gln Lys Gly Lys Thr Ala Thr Lys 
        355                 360                 365             


Asp Arg Lys Leu Lys Asn Lys Ala Ser Met Thr Pro Gly Leu His Pro 
    370                 375                 380                 


Gly Ser Thr Leu Ile Pro Met Asn Asn Ile Ser Val Pro Gln Glu Asp 
385                 390                 395                 400 


Asp Tyr Gly Tyr Gln Cys Leu Glu Gly Lys Asp Cys Ala Ser Phe Phe 
                405                 410                 415     


Cys Cys Phe Glu Asp Cys Arg Thr Gly Ser Trp Arg Glu Gly Arg Ile 
            420                 425                 430         


His Ile Arg Ile Ala Lys Ile Asp Ser Tyr Ser Arg Ile Phe Phe Pro 
        435                 440                 445             


Thr Ala Phe Ala Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr 
    450                 455                 460                 


Leu 
465 


<210>  128
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr 
            340                 345                 350         


Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe 
        355                 360                 365             


Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr 
    370                 375                 380                 


Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly 
385                 390                 395                 400 


Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His 
                405                 410                 415     


Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe 
            420                 425                 430         


Tyr Trp Ala Tyr Tyr Met Tyr Phe 
        435                 440 


<210>  129
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210>  130
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Val Tyr Lys Thr Leu Phe Ala Leu Cys Ile Leu Thr Ala Gly Trp 
1               5                   10                  15      


Arg Val Gln Ser Leu Pro Thr Ser Ala Pro Leu Ser Val Ser Leu Pro 
            20                  25                  30          


Thr Asn Ile Val Pro Pro Thr Thr Ile Trp Thr Ser Ser Pro Gln Asn 
        35                  40                  45              


Thr Asp Ala Asp Thr Ala Ser Pro Ser Asn Gly Thr His Asn Asn Ser 
    50                  55                  60                  


Val Leu Pro Val Thr Ala Ser Ala Pro Thr Ser Leu Leu Pro Lys Asn 
65                  70                  75                  80  


Ile Ser Ile Glu Ser Arg Glu Glu Glu Ile Thr Ser Pro Gly Ser Asn 
                85                  90                  95      


Trp Glu Gly Thr Asn Thr Asp Pro Ser Pro Ser Gly Phe Ser Ser Thr 
            100                 105                 110         


Ser Gly Gly Val His Leu Thr Thr Thr Leu Glu Glu His Ser Ser Gly 
        115                 120                 125             


Thr Pro Glu Ala Gly Val Ala Ala Thr Leu Ser Gln Ser Ala Ala Glu 
    130                 135                 140                 


Pro Pro Thr Leu Ile Ser Pro Gln Ala Pro Ala Ser Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Thr Ser Pro Pro Glu Val Phe Ser Ala Ser Val Thr Thr Asn 
                165                 170                 175     


His Ser Ser Thr Val Thr Ser Thr Gln Pro Thr Gly Ala Pro Thr Ala 
            180                 185                 190         


Pro Glu Ser Pro Thr Glu Glu Ser Ser Ser Asp His Thr Pro Thr Ser 
        195                 200                 205             


His Ala Thr Ala Glu Pro Val Pro Gln Glu Lys Thr Pro Pro Thr Thr 
    210                 215                 220                 


Val Ser Gly Lys Val Met Cys Glu Leu Ile Asp Met Glu Thr Thr Thr 
225                 230                 235                 240 


Thr Phe Pro Arg Val Ile Met Gln Glu Val Glu His Ala Leu Ser Ser 
                245                 250                 255     


Gly Ser Ile Ala Ala Ile Thr Val Thr Val Ile Ala Val Val Leu Leu 
            260                 265                 270         


Val Phe Gly Val Ala Ala Tyr Leu Lys Ile Arg His Ser Ser Tyr Gly 
        275                 280                 285             


Arg Leu Leu Asp Asp His Asp Tyr Gly Ser Trp Gly Asn Tyr Asn Asn 
    290                 295                 300                 


Pro Leu Tyr Asp Asp Ser 
305                 310 


<210>  131
<211>  2595
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp 
1               5                   10                  15      


Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp 
            20                  25                  30          


Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro 
        35                  40                  45              


Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  


Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser 
65                  70                  75                  80  


Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys 
                85                  90                  95      


Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser 
            100                 105                 110         


Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val 
        115                 120                 125             


Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser 
    130                 135                 140                 


Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val 
145                 150                 155                 160 


Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr 
                165                 170                 175     


Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile 
            180                 185                 190         


Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn 
        195                 200                 205             


Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu 
    210                 215                 220                 


Leu Asn Lys Gln Phe Ser Gln Leu Ser Ser Asp Pro Asn Asn Gln Lys 
225                 230                 235                 240 


Ile Val Phe Gln Glu Ile Val Arg Met Leu Ser Phe Phe Ser Gln Val 
                245                 250                 255     


Gln Glu Gln Lys Ala Val Trp Gln Leu Leu Ser Ser Phe Pro Asn Val 
            260                 265                 270         


Phe Gln Asn Asp Thr Ser Leu Ser Asn Leu Phe Asp Val Leu Arg Lys 
        275                 280                 285             


Ala Asn Ser Val Leu Leu Val Val Gln Lys Val Tyr Pro Arg Phe Ala 
    290                 295                 300                 


Thr Asn Glu Gly Phe Arg Thr Leu Gln Lys Ser Val Lys His Leu Leu 
305                 310                 315                 320 


Tyr Thr Leu Asp Ser Pro Ala Gln Gly Asp Ser Asp Asn Ile Thr His 
                325                 330                 335     


Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser Leu Ala 
            340                 345                 350         


Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu Asn Ile 
        355                 360                 365             


Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg Asn Val 
    370                 375                 380                 


Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu Leu Gln 
385                 390                 395                 400 


Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser Tyr Glu 
                405                 410                 415     


Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu Ser Gln 
            420                 425                 430         


Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe Ser Leu 
        435                 440                 445             


Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser Leu Cys 
    450                 455                 460                 


Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu Leu Gly 
465                 470                 475                 480 


Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile Ser Lys 
                485                 490                 495     


Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn Leu Asn 
            500                 505                 510         


Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu Glu Asn 
        515                 520                 525             


Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val Asn Asn 
    530                 535                 540                 


Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met Phe Lys 
545                 550                 555                 560 


Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly Met Ser 
                565                 570                 575     


Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp Asn Arg 
            580                 585                 590         


Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp Thr Asn 
        595                 600                 605             


Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys Asn Leu 
    610                 615                 620                 


Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu Thr Leu 
625                 630                 635                 640 


Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe Phe Pro 
                645                 650                 655     


Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe Ile Arg 
            660                 665                 670         


Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro Leu Leu 
        675                 680                 685             


Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser Val Pro 
    690                 695                 700                 


Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro Gln Gly 
705                 710                 715                 720 


Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile Thr Thr 
                725                 730                 735     


Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys Gly Asn 
            740                 745                 750         


His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln Ile Ala 
        755                 760                 765             


Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe Ser Leu 
    770                 775                 780                 


Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp Ala Phe 
785                 790                 795                 800 


Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr Asn Pro 
                805                 810                 815     


Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg Gln Leu 
            820                 825                 830         


Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser Pro Leu 
        835                 840                 845             


Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met Leu Gln 
    850                 855                 860                 


Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe Ser Val 
865                 870                 875                 880 


Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu Asp Ile 
                885                 890                 895     


Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln Leu Asn 
            900                 905                 910         


Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu Tyr Asp 
        915                 920                 925             


Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu Ala Lys 
    930                 935                 940                 


Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe Lys Leu 
945                 950                 955                 960 


Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn Val Phe 
                965                 970                 975     


Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys Thr Ala 
            980                 985                 990         


Gln Thr Thr Arg Ser Leu Arg Thr  Lys Ile Trp Ala Pro  Gly Pro His 
        995                 1000                 1005             


Asn Ser  Pro Ser His Asn Gln  Ile Tyr Gly Arg Ala  Phe Ile Tyr 
    1010                 1015                 1020             


Leu Gln  Asp Ser Ile Glu Arg  Ala Ile Ile Glu Leu  Gln Thr Gly 
    1025                 1030                 1035             


Arg Asn  Ser Gln Glu Ile Ala  Val Gln Val Gln Ala  Ile Pro Tyr 
    1040                 1045                 1050             


Pro Cys  Phe Met Lys Asp Asn  Phe Leu Thr Ser Val  Ser Tyr Ser 
    1055                 1060                 1065             


Leu Pro  Ile Val Leu Met Val  Ala Trp Val Val Phe  Ile Ala Ala 
    1070                 1075                 1080             


Phe Val  Lys Lys Leu Val Tyr  Glu Lys Asp Leu Arg  Leu His Glu 
    1085                 1090                 1095             


Tyr Met  Lys Met Met Gly Val  Asn Ser Cys Ser His  Phe Phe Ala 
    1100                 1105                 1110             


Trp Leu  Ile Glu Ser Val Gly  Phe Leu Leu Val Thr  Ile Val Ile 
    1115                 1120                 1125             


Leu Ile  Ile Ile Leu Lys Phe  Gly Asn Ile Leu Pro  Lys Thr Asn 
    1130                 1135                 1140             


Gly Phe  Ile Leu Phe Leu Tyr  Phe Ser Asp Tyr Ser  Phe Ser Val 
    1145                 1150                 1155             


Ile Ala  Met Ser Tyr Leu Ile  Ser Val Phe Phe Asn  Asn Thr Asn 
    1160                 1165                 1170             


Ile Ala  Ala Leu Ile Gly Ser  Leu Ile Tyr Ile Ile  Ala Phe Phe 
    1175                 1180                 1185             


Pro Phe  Ile Val Leu Val Thr  Val Glu Asn Glu Leu  Ser Tyr Val 
    1190                 1195                 1200             


Leu Lys  Val Phe Met Ser Leu  Leu Ser Pro Thr Ala  Phe Ser Tyr 
    1205                 1210                 1215             


Ala Ser  Gln Tyr Ile Ala Arg  Tyr Glu Glu Gln Gly  Ile Gly Leu 
    1220                 1225                 1230             


Gln Trp  Glu Asn Met Tyr Thr  Ser Pro Val Gln Asp  Asp Thr Thr 
    1235                 1240                 1245             


Ser Phe  Gly Trp Leu Cys Cys  Leu Ile Leu Ala Asp  Ser Phe Ile 
    1250                 1255                 1260             


Tyr Phe  Leu Ile Ala Trp Tyr  Val Arg Asn Val Phe  Pro Gly Thr 
    1265                 1270                 1275             


Tyr Gly  Met Ala Ala Pro Trp  Tyr Phe Pro Ile Leu  Pro Ser Tyr 
    1280                 1285                 1290             


Trp Lys  Glu Arg Phe Gly Cys  Ala Glu Val Lys Pro  Glu Lys Ser 
    1295                 1300                 1305             


Asn Gly  Leu Met Phe Thr Asn  Ile Met Met Gln Asn  Thr Asn Pro 
    1310                 1315                 1320             


Ser Ala  Ser Pro Glu Tyr Met  Phe Ser Ser Asn Ile  Glu Pro Glu 
    1325                 1330                 1335             


Pro Lys  Asp Leu Thr Val Gly  Val Ala Leu His Gly  Val Thr Lys 
    1340                 1345                 1350             


Ile Tyr  Gly Ser Lys Val Ala  Val Asp Asn Leu Asn  Leu Asn Phe 
    1355                 1360                 1365             


Tyr Glu  Gly His Ile Thr Ser  Leu Leu Gly Pro Asn  Gly Ala Gly 
    1370                 1375                 1380             


Lys Thr  Thr Thr Ile Ser Met  Leu Thr Gly Leu Phe  Gly Ala Ser 
    1385                 1390                 1395             


Ala Gly  Thr Ile Phe Val Tyr  Gly Lys Asp Ile Lys  Thr Asp Leu 
    1400                 1405                 1410             


His Thr  Val Arg Lys Asn Met  Gly Val Cys Met Gln  His Asp Val 
    1415                 1420                 1425             


Leu Phe  Ser Tyr Leu Thr Thr  Lys Glu His Leu Leu  Leu Tyr Gly 
    1430                 1435                 1440             


Ser Ile  Lys Val Pro His Trp  Thr Lys Lys Gln Leu  His Glu Glu 
    1445                 1450                 1455             


Val Lys  Arg Thr Leu Lys Asp  Thr Gly Leu Tyr Ser  His Arg His 
    1460                 1465                 1470             


Lys Arg  Val Gly Thr Leu Ser  Gly Gly Met Lys Arg  Lys Leu Ser 
    1475                 1480                 1485             


Ile Ser  Ile Ala Leu Ile Gly  Gly Ser Arg Val Val  Ile Leu Asp 
    1490                 1495                 1500             


Glu Pro  Ser Thr Gly Val Asp  Pro Cys Ser Arg Arg  Ser Ile Trp 
    1505                 1510                 1515             


Asp Val  Ile Ser Lys Asn Lys  Thr Ala Arg Thr Ile  Ile Leu Ser 
    1520                 1525                 1530             


Thr His  His Leu Asp Glu Ala  Glu Val Leu Ser Asp  Arg Ile Ala 
    1535                 1540                 1545             


Phe Leu  Glu Gln Gly Gly Leu  Arg Cys Cys Gly Ser  Pro Phe Tyr 
    1550                 1555                 1560             


Leu Lys  Glu Ala Phe Gly Asp  Gly Tyr His Leu Thr  Leu Thr Lys 
    1565                 1570                 1575             


Lys Lys  Ser Pro Asn Leu Asn  Ala Asn Ala Val Cys  Asp Thr Met 
    1580                 1585                 1590             


Ala Val  Thr Ala Met Ile Gln  Ser His Leu Pro Glu  Ala Tyr Leu 
    1595                 1600                 1605             


Lys Glu  Asp Ile Gly Gly Glu  Leu Val Tyr Val Leu  Pro Pro Phe 
    1610                 1615                 1620             


Ser Thr  Lys Val Ser Gly Ala  Tyr Leu Ser Leu Leu  Arg Ala Leu 
    1625                 1630                 1635             


Asp Asn  Gly Met Gly Asp Leu  Asn Ile Gly Cys Tyr  Gly Ile Ser 
    1640                 1645                 1650             


Asp Thr  Thr Val Glu Glu Val  Phe Leu Asn Leu Thr  Lys Glu Ser 
    1655                 1660                 1665             


Gln Lys  Asn Ser Ala Met Ser  Leu Glu His Leu Thr  Gln Lys Lys 
    1670                 1675                 1680             


Ile Gly  Asn Ser Asn Ala Asn  Gly Ile Ser Thr Pro  Asp Asp Leu 
    1685                 1690                 1695             


Ser Val  Ser Ser Ser Asn Phe  Thr Asp Arg Asp Asp  Lys Ile Leu 
    1700                 1705                 1710             


Thr Arg  Gly Glu Arg Leu Asp  Gly Phe Gly Leu Leu  Leu Lys Lys 
    1715                 1720                 1725             


Ile Met  Ala Ile Leu Ile Lys  Arg Phe His His Thr  Arg Arg Asn 
    1730                 1735                 1740             


Trp Lys  Gly Leu Ile Ala Gln  Val Ile Leu Pro Ile  Val Phe Val 
    1745                 1750                 1755             


Thr Thr  Ala Met Gly Leu Gly  Thr Leu Arg Asn Ser  Ser Asn Ser 
    1760                 1765                 1770             


Tyr Pro  Glu Ile Gln Ile Ser  Pro Ser Leu Tyr Gly  Thr Ser Glu 
    1775                 1780                 1785             


Gln Thr  Ala Phe Tyr Ala Asn  Tyr His Pro Ser Thr  Glu Ala Leu 
    1790                 1795                 1800             


Val Ser  Ala Met Trp Asp Phe  Pro Gly Ile Asp Asn  Met Cys Leu 
    1805                 1810                 1815             


Asn Thr  Ser Asp Leu Gln Cys  Leu Asn Lys Asp Ser  Leu Glu Lys 
    1820                 1825                 1830             


Trp Asn  Thr Ser Gly Glu Pro  Ile Thr Asn Phe Gly  Val Cys Ser 
    1835                 1840                 1845             


Cys Ser  Glu Asn Val Gln Glu  Cys Pro Lys Phe Asn  Tyr Ser Pro 
    1850                 1855                 1860             


Pro His  Arg Arg Thr Tyr Ser  Ser Gln Val Ile Tyr  Asn Leu Thr 
    1865                 1870                 1875             


Gly Gln  Arg Val Glu Asn Tyr  Leu Ile Ser Thr Ala  Asn Glu Phe 
    1880                 1885                 1890             


Val Gln  Lys Arg Tyr Gly Gly  Trp Ser Phe Gly Leu  Pro Leu Thr 
    1895                 1900                 1905             


Lys Asp  Leu Arg Phe Asp Ile  Thr Gly Val Pro Ala  Asn Arg Thr 
    1910                 1915                 1920             


Leu Ala  Lys Val Trp Tyr Asp  Pro Glu Gly Tyr His  Ser Leu Pro 
    1925                 1930                 1935             


Ala Tyr  Leu Asn Ser Leu Asn  Asn Phe Leu Leu Arg  Val Asn Met 
    1940                 1945                 1950             


Ser Lys  Tyr Asp Ala Ala Arg  His Gly Ile Ile Met  Tyr Ser His 
    1955                 1960                 1965             


Pro Tyr  Pro Gly Val Gln Asp  Gln Glu Gln Ala Thr  Ile Ser Ser 
    1970                 1975                 1980             


Leu Ile  Asp Ile Leu Val Ala  Leu Ser Ile Leu Met  Gly Tyr Ser 
    1985                 1990                 1995             


Val Thr  Thr Ala Ser Phe Val  Thr Tyr Val Val Arg  Glu His Gln 
    2000                 2005                 2010             


Thr Lys  Ala Lys Gln Leu Gln  His Ile Ser Gly Ile  Gly Val Thr 
    2015                 2020                 2025             


Cys Tyr  Trp Val Thr Asn Phe  Ile Tyr Asp Met Val  Phe Tyr Leu 
    2030                 2035                 2040             


Val Pro  Val Ala Phe Ser Ile  Gly Ile Ile Ala Ile  Phe Lys Leu 
    2045                 2050                 2055             


Pro Ala  Phe Tyr Ser Glu Asn  Asn Leu Gly Ala Val  Ser Leu Leu 
    2060                 2065                 2070             


Leu Leu  Leu Phe Gly Tyr Ala  Thr Phe Ser Trp Met  Tyr Leu Leu 
    2075                 2080                 2085             


Ala Gly  Leu Phe His Glu Thr  Gly Met Ala Phe Ile  Thr Tyr Val 
    2090                 2095                 2100             


Cys Val  Asn Leu Phe Phe Gly  Ile Asn Ser Ile Val  Ser Leu Ser 
    2105                 2110                 2115             


Val Val  Tyr Phe Leu Ser Lys  Glu Lys Pro Asn Asp  Pro Thr Leu 
    2120                 2125                 2130             


Glu Leu  Ile Ser Glu Thr Leu  Lys Arg Ile Phe Leu  Ile Phe Pro 
    2135                 2140                 2145             


Gln Phe  Cys Phe Gly Tyr Gly  Leu Ile Glu Leu Ser  Gln Gln Gln 
    2150                 2155                 2160             


Ser Val  Leu Asp Phe Leu Lys  Ala Tyr Gly Val Glu  Tyr Pro Asn 
    2165                 2170                 2175             


Glu Thr  Phe Glu Met Asn Lys  Leu Gly Ala Met Phe  Val Ala Leu 
    2180                 2185                 2190             


Val Ser  Gln Gly Thr Met Phe  Phe Ser Leu Arg Leu  Leu Ile Asn 
    2195                 2200                 2205             


Glu Ser  Leu Ile Lys Lys Leu  Arg Leu Phe Phe Arg  Lys Phe Asn 
    2210                 2215                 2220             


Ser Ser  His Val Arg Glu Thr  Ile Asp Glu Asp Glu  Asp Val Arg 
    2225                 2230                 2235             


Ala Glu  Arg Leu Arg Val Glu  Ser Gly Ala Ala Glu  Phe Asp Leu 
    2240                 2245                 2250             


Val Gln  Leu Tyr Cys Leu Thr  Lys Thr Tyr Gln Leu  Ile His Lys 
    2255                 2260                 2265             


Lys Ile  Ile Ala Val Asn Asn  Ile Ser Ile Gly Ile  Pro Ala Gly 
    2270                 2275                 2280             


Glu Cys  Phe Gly Leu Leu Gly  Val Asn Gly Ala Gly  Lys Thr Thr 
    2285                 2290                 2295             


Ile Phe  Lys Met Leu Thr Gly  Asp Ile Ile Pro Ser  Ser Gly Asn 
    2300                 2305                 2310             


Ile Leu  Ile Arg Asn Lys Thr  Gly Ser Leu Gly His  Val Asp Ser 
    2315                 2320                 2325             


His Ser  Ser Leu Val Gly Tyr  Cys Pro Gln Glu Asp  Ala Leu Asp 
    2330                 2335                 2340             


Asp Leu  Val Thr Val Glu Glu  His Leu Tyr Phe Tyr  Ala Arg Val 
    2345                 2350                 2355             


His Gly  Ile Pro Glu Lys Asp  Ile Lys Glu Thr Val  His Lys Leu 
    2360                 2365                 2370             


Leu Arg  Arg Leu His Leu Met  Pro Phe Lys Asp Arg  Ala Thr Ser 
    2375                 2380                 2385             


Met Cys  Ser Tyr Gly Thr Lys  Arg Lys Leu Ser Thr  Ala Leu Ala 
    2390                 2395                 2400             


Leu Ile  Gly Lys Pro Ser Ile  Leu Leu Leu Asp Glu  Pro Ser Ser 
    2405                 2410                 2415             


Gly Met  Asp Pro Lys Ser Lys  Arg His Leu Trp Lys  Ile Ile Ser 
    2420                 2425                 2430             


Glu Glu  Val Gln Asn Lys Cys  Ser Val Ile Leu Thr  Ser His Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val 
    2450                 2455                 2460             


Asn Gly  Lys Phe Gln Cys Ile  Gly Ser Leu Gln His  Ile Lys Ser 
    2465                 2470                 2475             


Arg Phe  Gly Arg Gly Phe Thr  Val Lys Val His Leu  Lys Asn Asn 
    2480                 2485                 2490             


Lys Val  Thr Met Glu Thr Leu  Thr Lys Phe Met Gln  Leu His Phe 
    2495                 2500                 2505             


Pro Lys  Thr Tyr Leu Lys Asp  Gln His Leu Ser Met  Leu Glu Tyr 
    2510                 2515                 2520             


His Val  Pro Val Thr Ala Gly  Gly Val Ala Asn Ile  Phe Asp Leu 
    2525                 2530                 2535             


Leu Glu  Thr Asn Lys Thr Ala  Leu Asn Ile Thr Asn  Phe Leu Val 
    2540                 2545                 2550             


Ser Gln  Thr Thr Leu Glu Glu  Val Phe Ile Asn Phe  Ala Lys Asp 
    2555                 2560                 2565             


Gln Lys  Ser Tyr Glu Thr Ala  Asp Thr Ser Ser Gln  Gly Ser Thr 
    2570                 2575                 2580             


Ile Ser  Val Asp Ser Gln Asp  Asp Gln Met Glu Ser  
    2585                 2590                 2595 


<210>  132
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Ser Gln Leu Thr Gln Arg Gly Ala Leu Phe Leu Leu Phe Phe 
1               5                   10                  15      


Leu Thr Pro Ala Val Thr Pro Thr Trp Tyr Ala Gly Ser Gly Tyr Tyr 
            20                  25                  30          


Pro Asp Glu Ser Tyr Asn Glu Val Tyr Ala Glu Glu Val Pro Gln Ala 
        35                  40                  45              


Pro Ala Leu Asp Tyr Arg Val Pro Arg Trp Cys Tyr Thr Leu Asn Ile 
    50                  55                  60                  


Gln Asp Gly Glu Ala Thr Cys Tyr Ser Pro Lys Gly Gly Asn Tyr His 
65                  70                  75                  80  


Ser Ser Leu Gly Thr Arg Cys Glu Leu Ser Cys Asp Arg Gly Phe Arg 
                85                  90                  95      


Leu Ile Gly Arg Arg Ser Val Gln Cys Leu Pro Ser Arg Arg Trp Ser 
            100                 105                 110         


Gly Thr Ala Tyr Cys Arg Gln Met Arg Cys His Ala Leu Pro Phe Ile 
        115                 120                 125             


Thr Ser Gly Thr Tyr Thr Cys Thr Asn Gly Val Leu Leu Asp Ser Arg 
    130                 135                 140                 


Cys Asp Tyr Ser Cys Ser Ser Gly Tyr His Leu Glu Gly Asp Arg Ser 
145                 150                 155                 160 


Arg Ile Cys Met Glu Asp Gly Arg Trp Ser Gly Gly Glu Pro Val Cys 
                165                 170                 175     


Val Asp Ile Asp Pro Pro Lys Ile Arg Cys Pro His Ser Arg Glu Lys 
            180                 185                 190         


Met Ala Glu Pro Glu Lys Leu Thr Ala Arg Val Tyr Trp Asp Pro Pro 
        195                 200                 205             


Leu Val Lys Asp Ser Ala Asp Gly Thr Ile Thr Arg Val Thr Leu Arg 
    210                 215                 220                 


Gly Pro Glu Pro Gly Ser His Phe Pro Glu Gly Glu His Val Ile Arg 
225                 230                 235                 240 


Tyr Thr Ala Tyr Asp Arg Ala Tyr Asn Arg Ala Ser Cys Lys Phe Ile 
                245                 250                 255     


Val Lys Val Gln Val Arg Arg Cys Pro Thr Leu Lys Pro Pro Gln His 
            260                 265                 270         


Gly Tyr Leu Thr Cys Thr Ser Ala Gly Asp Asn Tyr Gly Ala Thr Cys 
        275                 280                 285             


Glu Tyr His Cys Asp Gly Gly Tyr Asp Arg Gln Gly Thr Pro Ser Arg 
    290                 295                 300                 


Val Cys Gln Ser Ser Arg Gln Trp Ser Gly Ser Pro Pro Ile Cys Ala 
305                 310                 315                 320 


Pro Met Lys Ile Asn Val Asn Val Asn Ser Ala Ala Gly Leu Leu Asp 
                325                 330                 335     


Gln Phe Tyr Glu Lys Gln Arg Leu Leu Ile Ile Ser Ala Pro Asp Pro 
            340                 345                 350         


Ser Asn Arg Tyr Tyr Lys Met Gln Ile Ser Met Leu Gln Gln Ser Thr 
        355                 360                 365             


Cys Gly Leu Asp Leu Arg His Val Thr Ile Ile Glu Leu Val Gly Gln 
    370                 375                 380                 


Pro Pro Gln Glu Val Gly Arg Ile Arg Glu Gln Gln Leu Ser Ala Asn 
385                 390                 395                 400 


Ile Ile Glu Glu Leu Arg Gln Phe Gln Arg Leu Thr Arg Ser Tyr Phe 
                405                 410                 415     


Asn Met Val Leu Ile Asp Lys Gln Gly Ile Asp Arg Asp Arg Tyr Met 
            420                 425                 430         


Glu Pro Val Thr Pro Glu Glu Ile Phe Thr Phe Ile Asp Asp Tyr Leu 
        435                 440                 445             


Leu Ser Asn Gln Glu Leu Thr Gln Arg Arg Glu Gln Arg Asp Ile Cys 
    450                 455                 460                 


Glu 
465 


<210>  133
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Asp Gln His Gln His Leu Asn Lys Thr Ala Glu Ser Ala Ser Ser 
1               5                   10                  15      


Glu Lys Lys Lys Thr Arg Arg Cys Asn Gly Phe Lys Met Phe Leu Ala 
            20                  25                  30          


Ala Leu Ser Phe Ser Tyr Ile Ala Lys Ala Leu Gly Gly Ile Ile Met 
        35                  40                  45              


Lys Ile Ser Ile Thr Gln Ile Glu Arg Arg Phe Asp Ile Ser Ser Ser 
    50                  55                  60                  


Leu Ala Gly Leu Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val 
65                  70                  75                  80  


Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu 
                85                  90                  95      


Ile Gly Ile Gly Cys Leu Leu Met Gly Thr Gly Ser Ile Leu Thr Ser 
            100                 105                 110         


Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr His 
        115                 120                 125             


Ile Asn Pro Ser Glu Asn Ser Thr Ser Ser Leu Ser Thr Cys Leu Ile 
    130                 135                 140                 


Asn Gln Thr Leu Ser Phe Asn Gly Thr Ser Pro Glu Ile Val Glu Lys 
145                 150                 155                 160 


Asp Cys Val Lys Glu Ser Gly Ser His Met Trp Ile Tyr Val Phe Met 
                165                 170                 175     


Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly 
            180                 185                 190         


Ile Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gly Ser Leu Asn Ala Ile Gly Met Ile Gly Pro Val Ile Gly Phe 
    210                 215                 220                 


Ala Leu Gly Ser Leu Phe Ala Lys Met Tyr Val Asp Ile Gly Tyr Val 
225                 230                 235                 240 


Asp Leu Ser Thr Ile Arg Ile Thr Pro Lys Asp Ser Arg Trp Val Gly 
                245                 250                 255     


Ala Trp Trp Leu Gly Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser 
            260                 265                 270         


Ser Ile Pro Phe Phe Phe Leu Pro Lys Asn Pro Asn Lys Pro Gln Lys 
        275                 280                 285             


Glu Arg Lys Ile Ser Leu Ser Leu His Val Leu Lys Thr Asn Asp Asp 
    290                 295                 300                 


Arg Asn Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Val Thr Lys 
305                 310                 315                 320 


Asn Val Thr Gly Phe Phe Gln Ser Leu Lys Ser Ile Leu Thr Asn Pro 
                325                 330                 335     


Leu Tyr Val Ile Phe Leu Leu Leu Thr Leu Leu Gln Val Ser Ser Phe 
            340                 345                 350         


Ile Gly Ser Phe Thr Tyr Val Phe Lys Tyr Met Glu Gln Gln Tyr Gly 
        355                 360                 365             


Gln Ser Ala Ser His Ala Asn Phe Leu Leu Gly Ile Ile Thr Ile Pro 
    370                 375                 380                 


Thr Val Ala Thr Gly Met Phe Leu Gly Gly Phe Ile Ile Lys Lys Phe 
385                 390                 395                 400 


Lys Leu Ser Leu Val Gly Ile Ala Lys Phe Ser Phe Leu Thr Ser Met 
                405                 410                 415     


Ile Ser Phe Leu Phe Gln Leu Leu Tyr Phe Pro Leu Ile Cys Glu Ser 
            420                 425                 430         


Lys Ser Val Ala Gly Leu Thr Leu Thr Tyr Asp Gly Asn Asn Ser Val 
        435                 440                 445             


Ala Ser His Val Asp Val Pro Leu Ser Tyr Cys Asn Ser Glu Cys Asn 
    450                 455                 460                 


Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Leu Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Ile Lys 
                485                 490                 495     


Lys His Thr Val Phe Tyr Asn Cys Ser Cys Val Glu Val Thr Gly Leu 
            500                 505                 510         


Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asn 
        515                 520                 525             


Thr Cys Thr Arg Lys Phe Phe Ile Tyr Val Ala Ile Gln Val Ile Asn 
    530                 535                 540                 


Ser Leu Phe Ser Ala Thr Gly Gly Thr Thr Phe Ile Leu Leu Thr Val 
545                 550                 555                 560 


Lys Ile Val Gln Pro Glu Leu Lys Ala Leu Ala Met Gly Phe Gln Ser 
                565                 570                 575     


Met Val Ile Arg Thr Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly 
            580                 585                 590         


Ala Leu Ile Asp Lys Thr Cys Met Lys Trp Ser Thr Asn Ser Cys Gly 
        595                 600                 605             


Ala Gln Gly Ala Cys Arg Ile Tyr Asn Ser Val Phe Phe Gly Arg Val 
    610                 615                 620                 


Tyr Leu Gly Leu Ser Ile Ala Leu Arg Phe Pro Ala Leu Val Leu Tyr 
625                 630                 635                 640 


Ile Val Phe Ile Phe Ala Met Lys Lys Lys Phe Gln Gly Lys Asp Thr 
                645                 650                 655     


Lys Ala Ser Asp Asn Glu Arg Lys Val Met Asp Glu Ala Asn Leu Glu 
            660                 665                 670         


Phe Leu Asn Asn Gly Glu His Phe Val Pro Ser Ala Gly Thr Asp Ser 
        675                 680                 685             


Lys Thr Cys Asn Leu Asp Met Gln Asp Asn Ala Ala Ala Asn 
    690                 695                 700         


<210>  134
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Arg Gly Arg Glu Leu Pro Leu Val Leu Leu Ala Leu Val Leu Cys 
1               5                   10                  15      


Leu Ala Pro Arg Gly Arg Ala Val Pro Leu Pro Ala Gly Gly Gly Thr 
            20                  25                  30          


Val Leu Thr Lys Met Tyr Pro Arg Gly Asn His Trp Ala Val Gly His 
        35                  40                  45              


Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser Glu Arg 
    50                  55                  60                  


Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu Glu Ala 
65                  70                  75                  80  


Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg Asn His 
                85                  90                  95      


Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser Trp Asp 
            100                 105                 110         


Ser Glu Asp Ser Ser Asn Phe Lys Asp Val Gly Ser Lys Gly Lys Val 
        115                 120                 125             


Gly Arg Leu Ser Ala Pro Gly Ser Gln Arg Glu Gly Arg Asn Pro Gln 
    130                 135                 140                 


Leu Asn Gln Gln 
145             


<210>  135
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  136
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
        35                  40                  45              


Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
            100                 105                 110         


Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
        115                 120                 125             


Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
    130                 135                 140                 


Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
145                 150                 155                 160 


Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                165                 170                 175     


Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
            180                 185                 190         


Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
        195                 200                 205             


Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
    210                 215                 220                 


Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
225                 230                 235                 240 


Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                245                 250                 255     


Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
            260                 265                 270         


Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
        275                 280                 285             


Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
    290                 295                 300                 


Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
305                 310                 315                 320 


Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                325                 330                 335     


Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
            340                 345                 350         


Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
        355                 360                 365             


Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
385                 390                 395                 400 


Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                405                 410                 415     


Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
465                 470                 475                 480 


Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                485                 490                 495     


Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
            500                 505                 510         


Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
    530                 535                 540                 


Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
            580                 585                 590         


Met Asp Thr Leu Pro Phe 
        595             


<210>  137
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  138
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ala Arg Gly Ala Glu Gly Gly Arg Gly Asp Ala Gly Trp Gly Leu 
1               5                   10                  15      


Arg Gly Ala Leu Ala Ala Val Ala Leu Leu Ser Ala Leu Asn Ala Ala 
            20                  25                  30          


Gly Thr Val Phe Ala Leu Cys Gln Trp Arg Gly Leu Ser Ser Ala Leu 
        35                  40                  45              


Arg Ala Leu Glu Ala Gln Arg Gly Arg Glu Gln Arg Glu Asp Ser Ala 
    50                  55                  60                  


Leu Arg Ser Phe Leu Ala Glu Leu Ser Arg Ala Pro Arg Gly Ala Ser 
65                  70                  75                  80  


Ala Pro Pro Gln Asp Pro Ala Ser Ser Ala Arg Asn Lys Arg Ser His 
                85                  90                  95      


Ser Gly Glu Pro Ala Pro His Ile Arg Ala Glu Ser His Asp Met Leu 
            100                 105                 110         


Met Met Met Thr Tyr Ser Met Val Pro Ile Arg Val Met Val Asp Leu 
        115                 120                 125             


Cys Asn Ser Thr Lys Gly Ile Cys Leu Thr Gly Pro Ser Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Ala Gly Gly Leu Pro Gly His Asn Gly Leu Asp Gly 
145                 150                 155                 160 


Gln Pro Gly Pro Gln Gly Pro Lys Gly Glu Lys Gly Ala Asn Gly Lys 
                165                 170                 175     


Arg Gly Lys Met Gly Ile Pro Gly Ala Ala Gly Asn Pro Gly Glu Arg 
            180                 185                 190         


Gly Glu Lys Gly Asp His Gly Glu Leu Gly Leu Gln Gly Asn Glu Gly 
        195                 200                 205             


Pro Pro Gly Gln Lys Gly Glu Lys Gly Asp Lys Gly Asp Val Ser Asn 
    210                 215                 220                 


Asp Val Leu Leu Ala Gly Ala Lys Gly Asp Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Arg 
                245                 250                 255     


Arg Ala Lys Gly Pro Arg Gln Pro Ser Met Phe Asn Gly Gln Cys Pro 
            260                 265                 270         


Gly Glu Thr Cys Ala Ile Pro Asn Asp Asp Thr Leu Val Gly Lys Ala 
        275                 280                 285             


Asp Glu Lys Ala Ser Glu His His Ser Pro Gln Ala Glu Ser Met Ile 
    290                 295                 300                 


Thr Ser Ile Gly Asn Pro Val Gln Val Leu Lys Val Thr Glu Thr Phe 
305                 310                 315                 320 


Gly Thr Trp Ile Arg Glu Ser Ala Asn Lys Ser Asp Asp Arg Ile Trp 
                325                 330                 335     


Val Thr Glu His Phe Ser Gly Ile Met Val Lys Glu Phe Lys Asp Gln 
            340                 345                 350         


Pro Ser Leu Leu Asn Gly Ser Tyr Thr Phe Ile His Leu Pro Tyr Tyr 
        355                 360                 365             


Phe His Gly Cys Gly His Val Val Tyr Asn Asn Ser Leu Tyr Tyr His 
    370                 375                 380                 


Lys Gly Gly Ser Asn Thr Leu Val Arg Phe Glu Phe Gly Gln Glu Thr 
385                 390                 395                 400 


Ser Gln Thr Leu Lys Leu Glu Asn Ala Leu Tyr Phe Asp Arg Lys Tyr 
                405                 410                 415     


Leu Phe Ala Asn Ser Lys Thr Tyr Phe Asn Leu Ala Val Asp Glu Lys 
            420                 425                 430         


Gly Leu Trp Ile Ile Tyr Ala Ser Ser Val Asp Gly Ser Ser Ile Leu 
        435                 440                 445             


Val Ala Gln Leu Asp Glu Arg Thr Phe Ser Val Val Gln His Val Asn 
    450                 455                 460                 


Thr Thr Tyr Pro Lys Ser Lys Ala Gly Asn Ala Phe Ile Ala Arg Gly 
465                 470                 475                 480 


Ile Leu Tyr Val Thr Asp Thr Lys Asp Met Arg Val Thr Phe Ala Phe 
                485                 490                 495     


Asp Leu Leu Gly Gly Lys Gln Ile Asn Ala Asn Phe Asp Leu Arg Thr 
            500                 505                 510         


Ser Gln Ser Val Leu Ala Met Leu Ala Tyr Asn Met Arg Asp Gln His 
        515                 520                 525             


Leu Tyr Ser Trp Glu Asp Gly His Leu Met Leu Tyr Pro Val Gln Phe 
    530                 535                 540                 


Leu Ser Thr Thr Leu Asn Gln 
545                 550     


<210>  139
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ala Arg Gly Ala Glu Gly Gly Arg Gly Asp Ala Gly Trp Gly Leu 
1               5                   10                  15      


Arg Gly Ala Leu Ala Ala Val Ala Leu Leu Ser Ala Leu Asn Ala Ala 
            20                  25                  30          


Gly Thr Val Phe Ala Leu Cys Gln Trp Arg Gly Leu Ser Ser Ala Leu 
        35                  40                  45              


Arg Ala Leu Glu Ala Gln Arg Gly Arg Glu Gln Arg Glu Asp Ser Ala 
    50                  55                  60                  


Leu Arg Ser Phe Leu Ala Glu Leu Ser Arg Ala Pro Arg Gly Ala Ser 
65                  70                  75                  80  


Ala Pro Pro Gln Asp Pro Ala Ser Ser Ala Arg Asn Lys Arg Ser His 
                85                  90                  95      


Ser Gly Glu Pro Ala Pro His Ile Arg Ala Glu Ser His Asp Met Leu 
            100                 105                 110         


Met Met Met Thr Tyr Ser Met Val Pro Ile Arg Val Met Val Asp Leu 
        115                 120                 125             


Cys Asn Ser Thr Lys Gly Ile Cys Leu Thr Gly Pro Ser Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Ala Gly Gly Leu Pro Gly His Asn Gly Leu Asp Gly 
145                 150                 155                 160 


Gln Pro Gly Pro Gln Gly Pro Lys Gly Glu Lys Gly Ala Asn Gly Lys 
                165                 170                 175     


Arg Gly Lys Met Gly Ile Pro Gly Ala Ala Gly Asn Pro Gly Glu Arg 
            180                 185                 190         


Gly Glu Lys Gly Asp His Gly Glu Leu Gly Leu Gln Gly Asn Glu Gly 
        195                 200                 205             


Pro Pro Gly Gln Lys Gly Glu Lys Gly Asp Lys Gly Asp Val Ser Asn 
    210                 215                 220                 


Asp Val Leu Leu Ala Gly Ala Lys Gly Asp Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Arg 
                245                 250                 255     


Arg Ala Lys Gly Pro Arg Gln Pro Ser Met Phe Asn Gly Gln Cys Pro 
            260                 265                 270         


Gly Glu Thr Cys Ala Ile Pro Asn Asp Asp Thr Leu Val Gly Lys Ala 
        275                 280                 285             


Asp Glu Lys Ala Ser Glu His His Ser Pro Gln Ala Glu Ser Met Ile 
    290                 295                 300                 


Thr Ser Ile Gly Asn Pro Val Gln Val Leu Lys Val Thr Glu Thr Phe 
305                 310                 315                 320 


Gly Thr Trp Ile Arg Glu Ser Ala Asn Lys Ser Asp Asp Arg Ile Trp 
                325                 330                 335     


Val Thr Glu His Phe Ser Gly Ile Met Val Lys Glu Phe Lys Asp Gln 
            340                 345                 350         


Pro Ser Leu Leu Asn Gly Ser Tyr Thr Phe Ile His Leu Pro Tyr Tyr 
        355                 360                 365             


Phe His Gly Cys Gly His Val Val Tyr Asn Asn Ser Leu Tyr Tyr His 
    370                 375                 380                 


Lys Gly Gly Ser Asn Thr Leu Val Arg Phe Glu Phe Gly Gln Glu Thr 
385                 390                 395                 400 


Ser Gln Thr Leu Lys Leu Glu Asn Ala Leu Tyr Phe Asp Arg Lys Tyr 
                405                 410                 415     


Leu Phe Ala Asn Ser Lys Thr Tyr Phe Asn Leu Ala Val Asp Glu Lys 
            420                 425                 430         


Gly Leu Trp Ile Ile Tyr Ala Ser Ser Val Asp Gly Ser Ser Ile Leu 
        435                 440                 445             


Val Ala Gln Leu Asp Glu Arg Thr Phe Ser Val Val Gln His Val Asn 
    450                 455                 460                 


Thr Thr Tyr Pro Lys Ser Lys Ala Gly Asn Ala Phe Ile Ala Arg Gly 
465                 470                 475                 480 


Ile Leu Tyr Val Thr Asp Thr Lys Asp Met Arg Val Thr Phe Ala Phe 
                485                 490                 495     


Asp Leu Leu Gly Gly Lys Gln Ile Asn Ala Asn Phe Asp Leu Arg Thr 
            500                 505                 510         


Ser Gln Ser Val Leu Ala Met Leu Ala Tyr Asn Met Arg Asp Gln His 
        515                 520                 525             


Leu Tyr Ser Trp Glu Asp Gly His Leu Met Leu Tyr Pro Val Gln Phe 
    530                 535                 540                 


Leu Ser Thr Thr Leu Asn Gln 
545                 550     


<210>  140
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


<210>  141
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ser Cys Ala Glu Val Met Tyr His Pro Gln Pro Tyr Gly Ala Ser 
1               5                   10                  15      


Gln Tyr Leu Pro Asn Pro Met Ala Ala Thr Thr Cys Pro Thr Ala Tyr 
            20                  25                  30          


Tyr Gln Pro Ala Pro Gln Pro Gly Gln Gln Lys Lys Leu Ala Val Phe 
        35                  40                  45              


Ser Lys Met Gln Asp Ser Leu Glu Val Thr Leu Pro Ser Lys Gln Glu 
    50                  55                  60                  


Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Lys Asp Gln Pro Ala Glu 
65                  70                  75                  80  


Met Glu Tyr Leu Asn Ser Arg Cys Val Leu Phe Thr Tyr Phe Gln Gly 
                85                  90                  95      


Asp Ile Gly Ser Val Val Asp Glu His Phe Ser Arg Ala Leu Gly Gln 
            100                 105                 110         


Ala Ile Thr Leu His Pro Glu Ser Ala Ile Ser Lys Ser Lys Met Gly 
        115                 120                 125             


Leu Thr Pro Leu Trp Arg Asp Ser Ser Ala Leu Ser Ser Gln Arg Asn 
    130                 135                 140                 


Ser Phe Pro Thr Ser Phe Trp Thr Ser Ser Tyr Gln Pro Pro Pro Ala 
145                 150                 155                 160 


Pro Cys Leu Gly Gly Val His Pro Asp Phe Gln Val Thr Gly Pro Pro 
                165                 170                 175     


Gly Thr Phe Ser Ala Ala Asp Pro Ser Pro Trp Pro Gly His Asn Leu 
            180                 185                 190         


His Gln Thr Gly Pro Ala Pro Pro Pro Ala Val Ser Glu Ser Trp Pro 
        195                 200                 205             


Tyr Pro Leu Thr Ser Gln Val Ser Pro Ser Tyr Ser His Met His Asp 
    210                 215                 220                 


Val Tyr Met Arg His His His Pro His Ala His Met His His Arg His 
225                 230                 235                 240 


Arg His His His His His His His Pro Pro Ala Gly Ser Ala Leu Asp 
                245                 250                 255     


Pro Ser Tyr Gly Pro Leu Leu Met Pro Ser Val His Ala Ala Arg Ile 
            260                 265                 270         


Pro Ala Pro Gln Cys Asp Ile Thr Lys Thr Glu Pro Thr Thr Val Thr 
        275                 280                 285             


Ser Ala Thr Ser Ala Trp Ala Gly Ala Phe His Gly Thr Val Asp Ile 
    290                 295                 300                 


Val Pro Ser Val Gly Phe Asp Thr Gly Leu Gln His Gln Asp Lys Ser 
305                 310                 315                 320 


Lys Glu Ser Pro Trp Tyr 
                325     


<210>  142
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  143
<211>  1941
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Asp Asp Lys Glu Pro Lys Arg Trp Pro Thr Leu Arg Asp Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Leu Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Gly Ile His Arg Ala Val Phe Tyr Arg Asp Leu Glu Glu Leu 
        35                  40                  45              


Lys Phe Val Leu Leu Thr Arg Tyr Asp Ile Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro Asn Ile Thr Asp 
        115                 120                 125             


Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser Tyr Gly Ala Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Glu Asp Glu Tyr Pro Pro Leu Phe Leu Ala Val Ser Gln Arg Lys 
                165                 170                 175     


Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Ile Asn Ala 
            180                 185                 190         


Val Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly 
        195                 200                 205             


Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Phe 
    210                 215                 220                 


Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr Ala Ser Glu Ala 
225                 230                 235                 240 


Lys Asn Arg Val Ile Phe Glu Leu Ile Tyr Glu Tyr Glu Arg Lys Lys 
                245                 250                 255     


His Glu Glu Leu Ser Ile Asn Ser Asn Pro Val Ser Ser Gln Lys Gln 
            260                 265                 270         


Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser Asn Ile 
        275                 280                 285             


Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser Ser Gln 
    290                 295                 300                 


Lys Gln Pro Ala Leu Lys Asp Thr Ser Asp Lys Asn Asp Ser Val Ser 
305                 310                 315                 320 


Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr Val Leu 
                325                 330                 335     


Pro Ala Val Glu Gln Cys Leu Asn Arg Ser Leu Tyr Arg Pro Asp Ala 
            340                 345                 350         


Val Ala Gln Pro Val Thr Glu Asp Glu Phe Ala Leu Glu Ser Glu Ile 
        355                 360                 365             


Ile Ser Lys Leu Tyr Ile Pro Lys Arg Lys Ile Ile Ser Pro Arg Ser 
    370                 375                 380                 


Ile Glu Asp Val Leu Pro Pro Val Glu Glu Ala Val Asp Arg Cys Leu 
385                 390                 395                 400 


Tyr Leu Leu Asp Arg Phe Ala Gln Ala Val Thr Lys Asp Lys Phe Ala 
                405                 410                 415     


Leu Glu Ser Glu Asn Ile Ser Glu Pro Tyr Phe Thr Asn Arg Arg Thr 
            420                 425                 430         


Ile Ser Gln Gln Ser Ala Glu Lys Leu Asp Ala Ala Cys Gly Ile Asp 
        435                 440                 445             


Lys Thr Glu Asn Gly Thr Leu Phe Glu Asp Gln Asn Val Asp Lys Glu 
    450                 455                 460                 


Gly Lys Ala Leu Pro Ala Thr Gly Gln Lys Ala Asn Val Ser Pro Glu 
465                 470                 475                 480 


Gln Pro Pro Leu Phe Thr His Thr Val Lys Asp Ser Asp His Ile Ser 
                485                 490                 495     


Thr Arg Phe Leu Gly Ser Met Asp Ser Leu Thr Ser Ser Glu Glu Ser 
            500                 505                 510         


Ser Glu Arg Pro Pro Leu Ser Thr Leu Thr Leu Lys Glu Ala Asp Pro 
        515                 520                 525             


Ser Ser Lys Ala Ala Met Arg Arg Lys Asp Ser Pro Pro Pro Gly Lys 
    530                 535                 540                 


Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp Asp Lys 
545                 550                 555                 560 


Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Pro Ile Ser 
                565                 570                 575     


Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp 
            580                 585                 590         


Glu Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Gln 
        595                 600                 605             


Gln Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Trp Lys Val Ile 
    610                 615                 620                 


Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Thr Gly 
625                 630                 635                 640 


Gly Gly Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Pro Ser Lys 
                645                 650                 655     


Ala Thr Ser Asp Lys Thr Asp Ser Ala Leu Asn Ile Ala Thr Glu Ile 
            660                 665                 670         


Lys Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Pro Ala 
        675                 680                 685             


Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser Asn Ile Ala Thr 
    690                 695                 700                 


Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Gln 
705                 710                 715                 720 


Pro Ala Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Leu Asn Ile 
                725                 730                 735     


Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Glu Thr Val Ser Ser Gln 
            740                 745                 750         


Lys Gln Pro Ala Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser 
        755                 760                 765             


Ile Ile Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser 
    770                 775                 780                 


Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Glu Asp Ser 
785                 790                 795                 800 


Val Leu Asn Ile Ala Arg Gly Lys Glu Asp Gly Glu Lys Thr Arg Arg 
                805                 810                 815     


Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys 
            820                 825                 830         


Asp Ser Phe Ser Asn Ile Thr Arg Glu Lys Lys Asp Gly Glu Thr Ser 
        835                 840                 845             


Arg Thr Val Ser Ser Gln Lys Pro Pro Ala Leu Lys Ala Thr Ser Asp 
    850                 855                 860                 


Glu Glu Asp Ser Val Leu Ser Ile Ala Arg Glu Glu Lys Asp Gly Glu 
865                 870                 875                 880 


Lys Ser Arg Thr Val Ser Ser Glu Gln Pro Pro Gly Leu Lys Ala Thr 
                885                 890                 895     


Arg Asp Glu Lys Asp Ser Leu Leu Asn Ile Ala Arg Gly Lys Lys His 
            900                 905                 910         


Gly Glu Lys Thr Arg Arg Val Ser Ser Arg Lys Lys Ala Ala Leu Lys 
        915                 920                 925             


Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg Glu Arg 
    930                 935                 940                 


Lys Asp Gly Glu Thr Ser Arg Thr Val Ser Ser Gln Lys Pro Pro Ala 
945                 950                 955                 960 


Leu Lys Ala Thr Ser Asp Glu Glu Asp Ser Val Leu Asn Ile Ala Arg 
                965                 970                 975     


Glu Lys Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Ser Glu Gln Pro 
            980                 985                 990         


Pro Gly Leu Lys Ala Thr Arg Asp  Glu Lys Asp Ser Leu  Leu Asn Ile 
        995                 1000                 1005             


Ala Arg  Gly Lys Lys Tyr Gly  Glu Lys Thr Arg Arg  Val Ser Ser 
    1010                 1015                 1020             


Gln Lys  Pro Pro Ala Leu Lys  Ala Thr Ser Asp Glu  Glu Asp Ser 
    1025                 1030                 1035             


Val Leu  Asn Ile Ala Arg Glu  Lys Lys Asp Gly Glu  Lys Ser Arg 
    1040                 1045                 1050             


Thr Val  Ser Ser Glu Gln Pro  Pro Gly Leu Lys Ala  Thr Arg Asp 
    1055                 1060                 1065             


Glu Lys  Asp Ser Leu Leu Asn  Ile Ala Arg Gly Lys  Lys His Gly 
    1070                 1075                 1080             


Glu Lys  Thr Arg Arg Val Ser  Ser Arg Lys Lys Ala  Ala Leu Lys 
    1085                 1090                 1095             


Ala Thr  Gly Asp Glu Glu Asp  Ser Val Leu Asn Ile  Ala Arg Glu 
    1100                 1105                 1110             


Lys Lys  Asp Gly Glu Lys Ser  Arg Thr Val Ser Ser  His Lys Gln 
    1115                 1120                 1125             


Pro Ala  Leu Lys Ala Thr Ser  Asp Lys Glu Asn Ser  Val Pro Asn 
    1130                 1135                 1140             


Met Ala  Thr Glu Thr Lys Asp  Glu Gln Ile Ser Gly  Thr Val Ser 
    1145                 1150                 1155             


Ser Gln  Lys Gln Pro Ala Leu  Lys Ala Thr Ser Asp  Lys Lys Asp 
    1160                 1165                 1170             


Ser Val  Ser Asn Ile Pro Thr  Glu Ile Lys Asp Gly  Gln Gln Ser 
    1175                 1180                 1185             


Gly Thr  Val Ser Ser Gln Lys  Gln Leu Ala Trp Lys  Ala Thr Ser 
    1190                 1195                 1200             


Val Lys  Lys Asp Ser Val Ser  Asn Ile Ala Thr Glu  Ile Lys Asp 
    1205                 1210                 1215             


Gly Gln  Ile Arg Gly Thr Gly  Ile Leu Glu Tyr Thr  Phe Asn Val 
    1220                 1225                 1230             


Met Phe  Asp Gln Ile Glu Glu  Lys Phe Thr Ser Pro  Asn Lys Ser 
    1235                 1240                 1245             


Ala Gly  Val Ser Pro Gln Lys  Gln Ser Ala Gln Lys  Val Ile Phe 
    1250                 1255                 1260             


Lys Lys  Lys Val Ser Leu Leu  Asn Ile Ala Thr Arg  Ile Thr Gly 
    1265                 1270                 1275             


Gly Trp  Lys Ser Gly Thr Glu  Tyr Pro Glu Asn Leu  Pro Thr Leu 
    1280                 1285                 1290             


Lys Ala  Thr Ile Glu Asn Lys  Asn Ser Val Leu Asn  Thr Ala Thr 
    1295                 1300                 1305             


Lys Met  Lys Asp Val Gln Thr  Ser Thr Pro Ala Glu  Gln Asp Leu 
    1310                 1315                 1320             


Glu Met  Ala Ser Glu Gly Glu  Gln Lys Arg Leu Glu  Glu Tyr Glu 
    1325                 1330                 1335             


Asn Asn  Gln Pro Gln Val Lys  Asn Gln Ile His Ser  Arg Asp Asp 
    1340                 1345                 1350             


Leu Asp  Asp Ile Ile Gln Ser  Ser Gln Thr Val Ser  Glu Asp Gly 
    1355                 1360                 1365             


Asp Ser  Leu Cys Cys Asn Cys  Lys Asn Val Ile Leu  Leu Ile Asp 
    1370                 1375                 1380             


Gln His  Glu Met Lys Cys Lys  Asp Cys Val His Leu  Leu Lys Ile 
    1385                 1390                 1395             


Lys Lys  Thr Phe Cys Leu Cys  Lys Arg Leu Thr Glu  Leu Lys Asp 
    1400                 1405                 1410             


Asn His  Cys Glu Gln Leu Arg  Val Lys Ile Arg Lys  Leu Lys Asn 
    1415                 1420                 1425             


Lys Ala  Ser Val Leu Gln Lys  Arg Leu Ser Glu Lys  Glu Glu Ile 
    1430                 1435                 1440             


Lys Ser  Gln Leu Lys His Glu  Thr Leu Glu Leu Glu  Lys Glu Leu 
    1445                 1450                 1455             


Cys Ser  Leu Arg Phe Ala Ile  Gln Gln Glu Lys Lys  Lys Arg Arg 
    1460                 1465                 1470             


Asn Val  Glu Glu Leu His Gln  Lys Val Arg Glu Lys  Leu Arg Ile 
    1475                 1480                 1485             


Thr Glu  Glu Gln Tyr Arg Ile  Glu Ala Asp Val Thr  Lys Pro Ile 
    1490                 1495                 1500             


Lys Pro  Ala Leu Lys Ser Ala  Glu Val Glu Leu Lys  Thr Gly Gly 
    1505                 1510                 1515             


Asn Asn  Ser Asn Gln Val Ser  Glu Thr Asp Glu Lys  Glu Asp Leu 
    1520                 1525                 1530             


Leu His  Glu Asn Arg Leu Met  Gln Asp Glu Ile Ala  Arg Leu Arg 
    1535                 1540                 1545             


Leu Glu  Lys Asp Thr Ile Lys  Asn Gln Asn Leu Glu  Lys Lys Tyr 
    1550                 1555                 1560             


Leu Lys  Asp Phe Glu Ile Val  Lys Arg Lys His Glu  Asp Leu Gln 
    1565                 1570                 1575             


Lys Ala  Leu Lys Arg Asn Glu  Glu Thr Leu Ala Glu  Thr Ile Ala 
    1580                 1585                 1590             


Cys Tyr  Ser Gly Gln Leu Ala  Ala Leu Thr Asp Glu  Asn Thr Thr 
    1595                 1600                 1605             


Leu Arg  Ser Lys Leu Glu Lys  Gln Arg Glu Ser Gly  Gln Arg Leu 
    1610                 1615                 1620             


Glu Thr  Glu Met Gln Ser Tyr  Arg Cys Arg Leu Asn  Ala Ala Leu 
    1625                 1630                 1635             


Cys Asp  His Asp Gln Ser His  Ser Ser Lys Arg Asp  Gln Glu Leu 
    1640                 1645                 1650             


Ala Phe  Gln Gly Thr Val Asp  Lys Cys Cys His Leu  Gln Glu Asn 
    1655                 1660                 1665             


Leu Asn  Ser His Val Leu Ile  Leu Ser Leu Gln Leu  Ser Lys Ala 
    1670                 1675                 1680             


Glu Ser  Lys Phe Arg Val Leu  Glu Thr Glu Leu His  Tyr Thr Gly 
    1685                 1690                 1695             


Glu Ala  Leu Lys Glu Lys Ala  Leu Val Phe Glu His  Val Gln Ser 
    1700                 1705                 1710             


Glu Leu  Lys Gln Lys Gln Ser  Gln Met Lys Asp Ile  Glu Lys Met 
    1715                 1720                 1725             


Tyr Lys  Ser Gly Tyr Asn Thr  Met Glu Lys Cys Ile  Glu Lys Gln 
    1730                 1735                 1740             


Glu Arg  Phe Cys Gln Leu Lys  Lys Gln Asn Met Leu  Leu Gln Gln 
    1745                 1750                 1755             


Gln Leu  Asp Asp Ala Arg Asn  Lys Ala Asp Asn Gln  Glu Lys Ala 
    1760                 1765                 1770             


Ile Leu  Asn Ile Gln Ala Arg  Cys Asp Ala Arg Val  Glu Asn Leu 
    1775                 1780                 1785             


Gln Ala  Glu Cys Arg Lys His  Arg Leu Leu Leu Glu  Glu Asp Asn 
    1790                 1795                 1800             


Lys Met  Leu Val Asn Glu Leu  Asn His Ser Lys Glu  Lys Lys Cys 
    1805                 1810                 1815             


Gln Tyr  Glu Lys Glu Lys Ala  Glu Arg Glu Val Ala  Val Arg Gln 
    1820                 1825                 1830             


Leu Gln  Gln Lys Gln Asp Asp  Val Leu Asn Lys Arg  Ser Ala Thr 
    1835                 1840                 1845             


Lys Ala  Leu Leu Asp Ala Ser  Ser Arg His Cys Ile  Tyr Leu Glu 
    1850                 1855                 1860             


Asn Gly  Met Gln Asp Ser Arg  Lys Lys Leu Asp Gln  Met Arg Ser 
    1865                 1870                 1875             


Gln Phe  Gln Glu Ile Gln Asp  Gln Leu Thr Ala Thr  Ile Arg Cys 
    1880                 1885                 1890             


Thr Lys  Glu Met Glu Gly Asp  Ala Gln Lys Leu Glu  Val Glu Asn 
    1895                 1900                 1905             


Val Met  Met Arg Lys Ile Ile  Lys Lys Gln Asp Glu  Gln Ile Glu 
    1910                 1915                 1920             


Arg Phe  Glu Lys Ile Leu Gln  His Ser Ser Leu Met  Leu Gln Val 
    1925                 1930                 1935             


Phe Glu  Ser 
    1940     


<210>  144
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  145
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Leu Ser Asn Leu His Glu Leu Leu Pro Asn His Leu Met Glu Thr 
1               5                   10                  15      


Leu Tyr Ser Arg Lys Ser Glu Glu Asp Lys Lys Lys Cys Glu Asn Pro 
            20                  25                  30          


Glu Leu Ser Gly Leu Glu Arg Ile Leu Ala Arg His Gln Leu Pro Lys 
        35                  40                  45              


Glu Ile Asn Leu Thr Pro Lys Pro Asn Arg Met Pro Pro Trp Lys Arg 
    50                  55                  60                  


Lys Ile Ile Asn Asn Val Thr Asp Gly Trp Lys Lys Cys His Leu Leu 
65                  70                  75                  80  


Lys Arg Asn Thr Lys Glu Pro Pro Met Ser Thr Ile Val Val Arg Lys 
                85                  90                  95      


Leu Ile Gln Lys Asn Val Pro Arg Arg His Ser Leu Arg Asn Thr Ser 
            100                 105                 110         


Arg Lys Leu Arg Asn Leu Pro Thr Thr Ala Lys Gly Thr Gln Thr Gly 
        115                 120                 125             


Lys Ser Gln Cys Leu Leu Gly Ile Ser Glu Pro Thr 
    130                 135                 140 


<210>  146
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  147
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val 
1               5                   10                  15      


Thr Leu Cys Tyr Gly Glu Trp Gln Lys Glu Glu Asn Phe Gly Phe Asp 
            20                  25                  30          


Ile Val Ser Val Leu Ser Leu Asn Trp His Arg Ala Gln Glu Ser His 
        35                  40                  45              


Glu Ser Met Glu Ser Tyr Glu Leu Asn Pro Phe Ile Asn Arg Arg Asn 
    50                  55                  60                  


Ala Asn Thr Phe Ile Ser Pro Gln Gln Arg Trp Arg Ala Lys Val Gln 
65                  70                  75                  80  


Glu Arg Ile Arg Glu Arg Ser Lys Pro Val His Glu Leu Asn Arg Glu 
                85                  90                  95      


Ala Cys Asp Asp Tyr Arg Leu Cys Glu Arg Tyr Ala Met Val Tyr Gly 
            100                 105                 110         


Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe Arg Lys Arg Arg Gly Thr Lys 
        115                 120                 125             


<210>  148
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Lys Ser Ser Gln Thr Phe Glu Glu Gln Thr Glu Cys Ile Val Asn 
1               5                   10                  15      


Thr Leu Leu Met Asp Phe Leu Ser Pro Thr Leu Gln Val Ala Ser Arg 
            20                  25                  30          


Asn Leu Cys Cys Val Asp Glu Val Asp Ser Gly Glu Pro Cys Ser Phe 
        35                  40                  45              


Asp Val Ala Ile Ile Ala Gly Arg Leu Arg Met Leu Gly Asp Gln Phe 
    50                  55                  60                  


Asn Gly Glu Leu Glu Ala Ser Ala Lys Asn Val Ile Ala Glu Thr Ile 
65                  70                  75                  80  


Lys Gly Gln Thr Gly Ala Ile Leu Gln Asp Thr Val Glu Ser Leu Ser 
                85                  90                  95      


Lys Thr Trp Cys Ala Gln Asp Ser Ser Leu Ala Tyr Glu Arg Ala Phe 
            100                 105                 110         


Leu Ala Val Ser Val Lys Leu Leu Glu Tyr Met Ala His Ile Ala Pro 
        115                 120                 125             


Glu Val Val Gly Gln Val Ala Ile Pro Met Thr Gly Met Ile Asn Gly 
    130                 135                 140                 


Asn Gln Ala Ile Arg Glu Phe Ile Gln Gly Gln Gly Gly Trp Glu Asn 
145                 150                 155                 160 


Leu Glu Ser 
            


<210>  149
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Gln Gly Asn Gly Ser Ala Leu Pro Asn Ala Ser Gln Pro Val Leu 
1               5                   10                  15      


Arg Gly Asp Gly Ala Arg Pro Ser Trp Leu Ala Ser Ala Leu Ala Cys 
            20                  25                  30          


Val Leu Ile Phe Thr Ile Val Val Asp Ile Leu Gly Asn Leu Leu Val 
        35                  40                  45              


Ile Leu Ser Val Tyr Arg Asn Lys Lys Leu Arg Asn Ala Gly Asn Ile 
    50                  55                  60                  


Phe Val Val Ser Leu Ala Val Ala Asp Leu Val Val Ala Ile Tyr Pro 
65                  70                  75                  80  


Tyr Pro Leu Val Leu Met Ser Ile Phe Asn Asn Gly Trp Asn Leu Gly 
                85                  90                  95      


Tyr Leu His Cys Gln Val Ser Gly Phe Leu Met Gly Leu Ser Val Ile 
            100                 105                 110         


Gly Ser Ile Phe Asn Ile Thr Gly Ile Ala Ile Asn Arg Tyr Cys Tyr 
        115                 120                 125             


Ile Cys His Ser Leu Lys Tyr Asp Lys Leu Tyr Ser Ser Lys Asn Ser 
    130                 135                 140                 


Leu Cys Tyr Val Leu Leu Ile Trp Leu Leu Thr Leu Ala Ala Val Leu 
145                 150                 155                 160 


Pro Asn Leu Arg Ala Gly Thr Leu Gln Tyr Asp Pro Arg Ile Tyr Ser 
                165                 170                 175     


Cys Thr Phe Ala Gln Ser Val Ser Ser Ala Tyr Thr Ile Ala Val Val 
            180                 185                 190         


Val Phe His Phe Leu Val Pro Met Ile Ile Val Ile Phe Cys Tyr Leu 
        195                 200                 205             


Arg Ile Trp Ile Leu Val Leu Gln Val Arg Gln Arg Val Lys Pro Asp 
    210                 215                 220                 


Arg Lys Pro Lys Leu Lys Pro Gln Asp Phe Arg Asn Phe Val Thr Met 
225                 230                 235                 240 


Phe Val Val Phe Val Leu Phe Ala Ile Cys Trp Ala Pro Leu Asn Phe 
                245                 250                 255     


Ile Gly Leu Ala Val Ala Ser Asp Pro Ala Ser Met Val Pro Arg Ile 
            260                 265                 270         


Pro Glu Trp Leu Phe Val Ala Ser Tyr Tyr Met Ala Tyr Phe Asn Ser 
        275                 280                 285             


Cys Leu Asn Ala Ile Ile Tyr Gly Leu Leu Asn Gln Asn Phe Arg Lys 
    290                 295                 300                 


Glu Tyr Arg Arg Ile Ile Val Ser Leu Cys Thr Ala Arg Val Phe Phe 
305                 310                 315                 320 


Val Asp Ser Ser Asn Asp Val Ala Asp Arg Val Lys Trp Lys Pro Ser 
                325                 330                 335     


Pro Leu Met Thr Asn Asn Asn Val Val Lys Val Asp Ser Val 
            340                 345                 350 


<210>  150
<211>  5412
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Lys Gly Ala Arg Trp Arg Arg Val Pro Trp Val Ser Leu Ser Cys 
1               5                   10                  15      


Leu Cys Leu Cys Leu Leu Pro His Val Val Pro Gly Thr Thr Glu Asp 
            20                  25                  30          


Thr Leu Ile Thr Gly Ser Lys Thr Ala Ala Pro Val Thr Ser Thr Gly 
        35                  40                  45              


Ser Thr Thr Ala Thr Leu Glu Gly Gln Ser Thr Ala Ala Ser Ser Arg 
    50                  55                  60                  


Thr Ser Asn Gln Asp Ile Ser Ala Ser Ser Gln Asn His Gln Thr Lys 
65                  70                  75                  80  


Ser Thr Glu Thr Thr Ser Lys Ala Gln Thr Asp Thr Leu Thr Gln Met 
                85                  90                  95      


Met Thr Ser Thr Leu Phe Ser Ser Pro Ser Val His Asn Val Met Glu 
            100                 105                 110         


Thr Ala Pro Pro Asp Glu Met Thr Thr Ser Phe Pro Ser Ser Val Thr 
        115                 120                 125             


Asn Thr Leu Met Met Thr Ser Lys Thr Ile Thr Met Thr Thr Ser Thr 
    130                 135                 140                 


Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser Thr Ala Gly Thr Glu 
145                 150                 155                 160 


Ser Ser Thr Pro Val Thr Ser Ala Val Ser Ile Thr Ala Gly Gln Glu 
                165                 170                 175     


Gly Gln Ser Arg Thr Thr Ser Trp Arg Thr Ser Ile Gln Asp Thr Ser 
            180                 185                 190         


Ala Ser Ser Gln Asn His Trp Thr Arg Ser Thr Gln Thr Thr Arg Glu 
        195                 200                 205             


Ser Gln Thr Ser Thr Leu Thr His Arg Thr Thr Ser Thr Pro Ser Phe 
    210                 215                 220                 


Ser Pro Ser Val His Asn Val Thr Gly Thr Val Ser Gln Lys Thr Ser 
225                 230                 235                 240 


Pro Ser Gly Glu Thr Ala Thr Ser Ser Leu Cys Ser Val Thr Asn Thr 
                245                 250                 255     


Ser Met Met Thr Ser Glu Lys Ile Thr Val Thr Thr Ser Thr Gly Ser 
            260                 265                 270         


Thr Leu Gly Asn Pro Gly Glu Thr Ser Ser Val Pro Val Thr Gly Ser 
        275                 280                 285             


Leu Met Pro Val Thr Ser Ala Ala Leu Val Thr Phe Asp Pro Glu Gly 
    290                 295                 300                 


Gln Ser Pro Ala Thr Phe Ser Arg Thr Ser Thr Gln Asp Thr Thr Ala 
305                 310                 315                 320 


Phe Ser Lys Asn His Gln Thr Gln Ser Val Glu Thr Thr Arg Val Ser 
                325                 330                 335     


Gln Ile Asn Thr Leu Asn Thr Leu Thr Pro Val Thr Thr Ser Thr Val 
            340                 345                 350         


Leu Ser Ser Pro Ser Gly Phe Asn Pro Ser Gly Thr Val Ser Gln Glu 
        355                 360                 365             


Thr Phe Pro Ser Gly Glu Thr Thr Thr Ser Ser Pro Ser Ser Val Ser 
    370                 375                 380                 


Asn Thr Phe Leu Val Thr Ser Lys Val Phe Arg Met Pro Thr Ser Arg 
385                 390                 395                 400 


Asp Ser Thr Leu Gly Asn Thr Glu Glu Thr Ser Leu Ser Val Ser Gly 
                405                 410                 415     


Thr Ile Ser Ala Ile Thr Ser Lys Val Ser Thr Ile Trp Trp Ser Asp 
            420                 425                 430         


Thr Leu Ser Thr Ala Leu Ser Pro Ser Ser Leu Pro Pro Lys Ile Ser 
        435                 440                 445             


Thr Ala Phe His Thr Gln Gln Ser Glu Gly Ala Glu Thr Thr Gly Arg 
    450                 455                 460                 


Pro His Glu Arg Ser Ser Phe Ser Pro Gly Val Ser Gln Glu Ile Phe 
465                 470                 475                 480 


Thr Leu His Glu Thr Thr Thr Trp Pro Ser Ser Phe Ser Ser Lys Gly 
                485                 490                 495     


His Thr Thr Trp Ser Gln Thr Glu Leu Pro Ser Thr Ser Thr Gly Ala 
            500                 505                 510         


Ala Thr Arg Leu Val Thr Gly Asn Pro Ser Thr Gly Thr Ala Gly Thr 
        515                 520                 525             


Ile Pro Arg Val Pro Ser Lys Val Ser Ala Ile Gly Glu Pro Gly Glu 
    530                 535                 540                 


Pro Thr Thr Tyr Ser Ser His Ser Thr Thr Leu Pro Lys Thr Thr Gly 
545                 550                 555                 560 


Ala Gly Ala Gln Thr Gln Trp Thr Gln Glu Thr Gly Thr Thr Gly Glu 
                565                 570                 575     


Ala Leu Leu Ser Ser Pro Ser Tyr Ser Val Thr Gln Met Ile Lys Thr 
            580                 585                 590         


Ala Thr Ser Pro Ser Ser Ser Pro Met Leu Asp Arg His Thr Ser Gln 
        595                 600                 605             


Gln Ile Thr Thr Ala Pro Ser Thr Asn His Ser Thr Ile His Ser Thr 
    610                 615                 620                 


Ser Thr Ser Pro Gln Glu Ser Pro Ala Val Ser Gln Arg Gly His Thr 
625                 630                 635                 640 


Gln Ala Pro Gln Thr Thr Gln Glu Ser Gln Thr Thr Arg Ser Val Ser 
                645                 650                 655     


Pro Met Thr Asp Thr Lys Thr Val Thr Thr Pro Gly Ser Ser Phe Thr 
            660                 665                 670         


Ala Ser Gly His Ser Pro Ser Glu Ile Val Pro Gln Asp Ala Pro Thr 
        675                 680                 685             


Ile Ser Ala Ala Thr Thr Phe Ala Pro Ala Pro Thr Gly Asp Gly His 
    690                 695                 700                 


Thr Thr Gln Ala Pro Thr Thr Ala Leu Gln Ala Ala Pro Ser Ser His 
705                 710                 715                 720 


Asp Ala Thr Leu Gly Pro Ser Gly Gly Thr Ser Leu Ser Lys Thr Gly 
                725                 730                 735     


Ala Leu Thr Leu Ala Asn Ser Val Val Ser Thr Pro Gly Gly Pro Glu 
            740                 745                 750         


Gly Gln Trp Thr Ser Ala Ser Ala Ser Thr Ser Pro Asp Thr Ala Ala 
        755                 760                 765             


Ala Met Thr His Thr His Gln Ala Glu Ser Thr Glu Ala Ser Gly Gln 
    770                 775                 780                 


Thr Gln Thr Ser Glu Pro Ala Ser Ser Gly Ser Arg Thr Thr Ser Ala 
785                 790                 795                 800 


Gly Thr Ala Thr Pro Ser Ser Ser Gly Ala Ser Gly Thr Thr Pro Ser 
                805                 810                 815     


Gly Ser Glu Gly Ile Ser Thr Ser Gly Glu Thr Thr Arg Phe Ser Ser 
            820                 825                 830         


Asn Pro Ser Arg Asp Ser His Thr Thr Gln Ser Thr Thr Glu Leu Leu 
        835                 840                 845             


Ser Ala Ser Ala Ser His Gly Ala Ile Pro Val Ser Thr Gly Met Ala 
    850                 855                 860                 


Ser Ser Ile Val Pro Gly Thr Phe His Pro Thr Leu Ser Glu Ala Ser 
865                 870                 875                 880 


Thr Ala Gly Arg Pro Thr Gly Gln Ser Ser Pro Thr Ser Pro Ser Ala 
                885                 890                 895     


Ser Pro Gln Glu Thr Ala Ala Ile Ser Arg Met Ala Gln Thr Gln Arg 
            900                 905                 910         


Thr Arg Thr Ser Arg Gly Ser Asp Thr Ile Ser Leu Ala Ser Gln Ala 
        915                 920                 925             


Thr Asp Thr Phe Ser Thr Val Pro Pro Thr Pro Pro Ser Ile Thr Ser 
    930                 935                 940                 


Thr Gly Leu Thr Ser Pro Gln Thr Glu Thr His Thr Leu Ser Pro Ser 
945                 950                 955                 960 


Gly Ser Gly Lys Thr Phe Thr Thr Ala Leu Ile Ser Asn Ala Thr Pro 
                965                 970                 975     


Leu Pro Val Thr Tyr Ala Ser Ser Ala Ser Thr Gly His Thr Thr Pro 
            980                 985                 990         


Leu His Val Thr Asp Ala Ser Ser  Val Ser Thr Gly His  Ala Thr Pro 
        995                 1000                 1005             


Leu Pro  Val Thr Ser Pro Ser  Ser Val Ser Thr Gly  His Thr Thr 
    1010                 1015                 1020             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Glu Ser Thr  Gly His Val 
    1025                 1030                 1035             


Thr Pro  Leu Pro Val Thr Ser  Phe Ser Ser Ala Ser  Thr Gly Asp 
    1040                 1045                 1050             


Ser Thr  Pro Leu Pro Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    1055                 1060                 1065             


His Val  Thr Pro Leu Pro Val  Thr Ser Leu Ser Ser  Ala Ser Thr 
    1070                 1075                 1080             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    1085                 1090                 1095             


Thr Gly  His Ala Thr Ser Leu  Pro Val Thr Asp Thr  Ser Ser Val 
    1100                 1105                 1110             


Ser Thr  Gly His Thr Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    1115                 1120                 1125             


Ala Ser  Thr Gly His Ala Thr  Ser Leu Pro Val Thr  Asp Thr Ser 
    1130                 1135                 1140             


Ser Val  Ser Thr Gly His Thr  Thr Pro Leu His Val  Thr Asp Ala 
    1145                 1150                 1155             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    1160                 1165                 1170             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    1175                 1180                 1185             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Leu Val 
    1190                 1195                 1200             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    1205                 1210                 1215             


Val Thr  Asp Ala Ser Ser Val  Ser Thr Asp His Ala  Thr Ser Leu 
    1220                 1225                 1230             


Pro Val  Thr Ile Pro Ser Ala  Ala Ser Thr Gly His  Thr Thr Pro 
    1235                 1240                 1245             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Gly  Gln Ala Thr 
    1250                 1255                 1260             


Ser Leu  Leu Val Thr Asp Thr  Ser Ser Val Ser Thr  Gly Asp Thr 
    1265                 1270                 1275             


Thr Pro  Leu Pro Val Thr Ser  Thr Ser Ser Ala Ser  Thr Gly His 
    1280                 1285                 1290             


Val Thr  Pro Leu His Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    1295                 1300                 1305             


His Ala  Thr Pro Leu Pro Val  Thr Ser Leu Ser Ser  Ala Ser Thr 
    1310                 1315                 1320             


Gly Asp  Thr Met Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1325                 1330                 1335             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asp Ala  Ser Ser Val 
    1340                 1345                 1350             


Ser Thr  Gly His Thr Thr Pro  Leu His Val Thr Asp  Ala Ser Ser 
    1355                 1360                 1365             


Ala Ser  Thr Gly Gln Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser 
    1370                 1375                 1380             


Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro 
    1385                 1390                 1395             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu Leu  Val Thr Asp 
    1400                 1405                 1410             


Thr Ser  Ser Ala Ser Thr Gly  His Ala Thr Pro Leu  Pro Val Thr 
    1415                 1420                 1425             


Asp Ala  Ser Ser Val Ser Thr  Asp His Ala Thr Ser  Leu Pro Val 
    1430                 1435                 1440             


Thr Ile  Pro Ser Ala Ala Ser  Thr Gly His Thr Thr  Pro Leu Pro 
    1445                 1450                 1455             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Ser Leu 
    1460                 1465                 1470             


Leu Val  Thr Asp Thr Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    1475                 1480                 1485             


Leu Pro  Val Thr Ser Thr Ser  Ser Ala Ser Thr Gly  His Val Thr 
    1490                 1495                 1500             


Pro Leu  His Val Thr Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala 
    1505                 1510                 1515             


Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp 
    1520                 1525                 1530             


Thr Met  Pro Leu Pro Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    1535                 1540                 1545             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Ala Ser Ser  Val Ser Thr 
    1550                 1555                 1560             


Gly His  Thr Thr Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1565                 1570                 1575             


Thr Gly  His Thr Thr Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala 
    1580                 1585                 1590             


Ser Lys  Gly Asp Thr Thr Pro  Leu Pro Val Thr Ser  Pro Ser Ser 
    1595                 1600                 1605             


Ala Ser  Thr Gly His Thr Thr  Pro Leu Pro Val Thr  Asp Thr Ser 
    1610                 1615                 1620             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asn Ala 
    1625                 1630                 1635             


Ser Ser  Leu Ser Thr Gly His  Ala Thr Pro Leu His  Val Thr Ser 
    1640                 1645                 1650             


Pro Ser  Ser Ala Ser Thr Gly  His Ala Thr Pro Leu  Pro Val Thr 
    1655                 1660                 1665             


Ser Thr  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    1670                 1675                 1680             


Thr Gly  Leu Ser Ser Ala Thr  Thr Asp Asp Thr Thr  Arg Leu Pro 
    1685                 1690                 1695             


Val Thr  Asp Val Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    1700                 1705                 1710             


Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    1715                 1720                 1725             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Ser 
    1730                 1735                 1740             


Pro Leu  Leu Val Thr Asp Ala  Ser Ser Ala Ser Thr  Gly Gln Ala 
    1745                 1750                 1755             


Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser Val Ser  Thr Ala His 
    1760                 1765                 1770             


Ala Thr  Pro Leu Pro Val Thr  Gly Leu Ser Ser Ala  Ser Thr Asp 
    1775                 1780                 1785             


Asp Thr  Thr Arg Leu Pro Val  Thr Asp Val Ser Ser  Ala Ser Thr 
    1790                 1795                 1800             


Gly Gln  Ala Ile Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    1805                 1810                 1815             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asp Ala  Ser Ser Ala 
    1820                 1825                 1830             


Ser Thr  Gly Asp Thr Thr Ser  Leu Pro Val Thr Ile  Pro Ser Ser 
    1835                 1840                 1845             


Ala Ser  Ser Gly His Thr Thr  Ser Leu Pro Val Thr  Asp Ala Ser 
    1850                 1855                 1860             


Ser Val  Ser Thr Gly His Ala  Thr Ser Leu Leu Val  Thr Asp Ala 
    1865                 1870                 1875             


Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asp 
    1880                 1885                 1890             


Thr Asn  Ser Ala Ser Thr Gly  Asp Thr Thr Pro Leu  His Val Thr 
    1895                 1900                 1905             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Ser  Leu Pro Val 
    1910                 1915                 1920             


Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Pro Leu Pro 
    1925                 1930                 1935             


Val Thr  Ser Pro Ser Ser Ala  Ser Ser Gly His Thr  Thr Pro Leu 
    1940                 1945                 1950             


Pro Val  Thr Asp Ala Ser Ser  Val Pro Thr Gly His  Ala Thr Ser 
    1955                 1960                 1965             


Leu Pro  Val Thr Asp Ala Ser  Ser Val Ser Thr Gly  His Ala Thr 
    1970                 1975                 1980             


Pro Leu  Pro Val Thr Asp Ala  Ser Ser Val Ser Thr  Gly His Ala 
    1985                 1990                 1995             


Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser Val Ser  Thr Gly Gln 
    2000                 2005                 2010             


Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser Ser Ala  Ser Thr Gly 
    2015                 2020                 2025             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    2030                 2035                 2040             


Gly Gln  Asp Thr Pro Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser 
    2045                 2050                 2055             


Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr Asn Pro  Ser Ser Ala 
    2060                 2065                 2070             


Ser Thr  Gly His Ala Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser 
    2075                 2080                 2085             


Ile Ser  Thr Gly His Ala Thr  Ser Leu Leu Val Thr  Asp Ala Ser 
    2090                 2095                 2100             


Ser Val  Ser Thr Gly His Ala  Thr Ala Leu His Asp  Thr Asp Ala 
    2105                 2110                 2115             


Ser Ser  Leu Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser 
    2120                 2125                 2130             


Pro Ser  Ser Thr Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    2135                 2140                 2145             


Glu Thr  Ser Ser Val Ser Thr  Gly His Ala Thr Ser  Leu Pro Val 
    2150                 2155                 2160             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  Ser Leu Pro 
    2165                 2170                 2175             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu 
    2180                 2185                 2190             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    2195                 2200                 2205             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Ile 
    2210                 2215                 2220             


Pro Leu  Leu Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly Gln Ala 
    2225                 2230                 2235             


Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser Ala Ser  Thr Gly Asp 
    2240                 2245                 2250             


Thr Thr  Pro Leu Pro Val Thr  Asp Ala Ser Ser Val  Ser Thr Gly 
    2255                 2260                 2265             


His Ala  Thr Ser Leu Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr 
    2270                 2275                 2280             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser 
    2285                 2290                 2295             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Asp Ala  Ser Ser Ala 
    2300                 2305                 2310             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Ser  Leu Ser Ser 
    2315                 2320                 2325             


Ala Ser  Thr Gly Asp Thr Thr  Pro Leu Pro Val Thr  Ser Pro Ser 
    2330                 2335                 2340             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu His Val  Thr Asp Ala 
    2345                 2350                 2355             


Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Ser 
    2360                 2365                 2370             


Ser Ser  Ser Ala Ser Ser Gly  His Thr Thr Pro Leu  Pro Val Thr 
    2375                 2380                 2385             


Asp Ala  Ser Ser Ala Ser Thr  Gly Asp Thr Thr Pro  Leu Pro Val 
    2390                 2395                 2400             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His Ala Thr  His Leu Pro 
    2405                 2410                 2415             


Val Thr  Gly Leu Ser Ser Ala  Ser Thr Gly Asp Thr  Thr Arg Leu 
    2420                 2425                 2430             


Pro Val  Thr Asn Val Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro 
    2435                 2440                 2445             


Leu Pro  Val Thr Ser Thr Ser  Ser Ala Ser Thr Gly  Asp Thr Thr 
    2450                 2455                 2460             


Pro Leu  Pro Gly Thr Asp Thr  Ser Ser Val Ser Thr  Gly His Thr 
    2465                 2470                 2475             


Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser Val Ser  Thr Gly Asp 
    2480                 2485                 2490             


Thr Thr  Arg Leu Pro Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly 
    2495                 2500                 2505             


His Thr  Thr Pro Leu Pro Val  Thr Asp Thr Pro Ser  Ala Ser Thr 
    2510                 2515                 2520             


Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asn Ala Ser  Ser Leu Ser 
    2525                 2530                 2535             


Thr Arg  His Ala Thr Ser Leu  His Val Thr Ser Pro  Ser Ser Ala 
    2540                 2545                 2550             


Ser Thr  Gly His Ala Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ala 
    2555                 2560                 2565             


Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Thr Ser 
    2570                 2575                 2580             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr 
    2585                 2590                 2595             


Tyr Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    2600                 2605                 2610             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    2615                 2620                 2625             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Leu Val 
    2630                 2635                 2640             


Thr Asp  Ala Ser Ser Ala Ser  Thr Gly Gln Ala Thr  Pro Leu Pro 
    2645                 2650                 2655             


Val Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    2660                 2665                 2670             


Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr Gly His  Ala Thr Ser 
    2675                 2680                 2685             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Gly  Asp Thr Thr 
    2690                 2695                 2700             


Ser Leu  Pro Val Thr Asp Thr  Ser Ser Ala Tyr Thr  Gly Asp Thr 
    2705                 2710                 2715             


Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser Ser Ser  Thr Gly Asp 
    2720                 2725                 2730             


Thr Thr  Pro Leu Leu Val Thr  Glu Thr Ser Ser Val  Ser Thr Gly 
    2735                 2740                 2745             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    2750                 2755                 2760             


Gly His  Ala Thr Pro Leu Pro  Val Thr Asn Thr Ser  Ser Val Ser 
    2765                 2770                 2775             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Ser Pro  Ser Ser Ala 
    2780                 2785                 2790             


Ser Thr  Gly His Thr Thr Pro  Leu Pro Val Thr Asp  Ala Ser Ser 
    2795                 2800                 2805             


Val Ser  Thr Gly His Ala Thr  Ser Leu Pro Val Thr  Asp Ala Ser 
    2810                 2815                 2820             


Ser Val  Phe Thr Gly His Ala  Thr Ser Leu Pro Val  Thr Ile Pro 
    2825                 2830                 2835             


Ser Ser  Ala Ser Ser Gly His  Thr Thr Pro Leu Pro  Val Thr Asp 
    2840                 2845                 2850             


Ala Ser  Ser Val Ser Thr Gly  His Ala Thr Ser Leu  Pro Val Thr 
    2855                 2860                 2865             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    2870                 2875                 2880             


Thr Asp  Ala Ser Ser Val Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    2885                 2890                 2895             


Leu Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    2900                 2905                 2910             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    2915                 2920                 2925             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    2930                 2935                 2940             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly His Ala 
    2945                 2950                 2955             


Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser Ala Ser  Thr Gly His 
    2960                 2965                 2970             


Ala Thr  Pro Leu Pro Asp Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    2975                 2980                 2985             


His Ala  Thr Leu Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Ile 
    2990                 2995                 3000             


Gly His  Ala Thr Ser Leu Pro  Val Thr Asp Thr Ser  Ser Ile Ser 
    3005                 3010                 3015             


Thr Gly  His Ala Thr Pro Leu  His Val Thr Ser Pro  Ser Ser Ala 
    3020                 3025                 3030             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    3035                 3040                 3045             


Ala Ser  Thr Gly His Ala Asn  Pro Leu His Val Thr  Ser Pro Ser 
    3050                 3055                 3060             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu Pro Val  Thr Asp Thr 
    3065                 3070                 3075             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu Pro  Val Thr Ser 
    3080                 3085                 3090             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    3095                 3100                 3105             


Ser Pro  Ser Ser Ala Ser Thr  Gly His Thr Thr Pro  Leu Pro Val 
    3110                 3115                 3120             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Gln Ala Thr  Ala Leu Pro 
    3125                 3130                 3135             


Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu 
    3140                 3145                 3150             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    3155                 3160                 3165             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    3170                 3175                 3180             


Pro Leu  Pro Val Thr Ser Pro  Ser Ser Ala Ser Thr  Gly His Ala 
    3185                 3190                 3195             


Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser Ala Ser  Thr Gly Gln 
    3200                 3205                 3210             


Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser Ser Val  Ser Thr Gly 
    3215                 3220                 3225             


Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr 
    3230                 3235                 3240             


Gly His  Ala Thr Ser Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    3245                 3250                 3255             


Thr Gly  Asp Thr Thr Ser Leu  Pro Val Thr Asp Thr  Ser Ser Ala 
    3260                 3265                 3270             


Tyr Thr  Gly Asp Thr Thr Ser  Leu Pro Val Thr Asp  Thr Ser Ser 
    3275                 3280                 3285             


Ser Ser  Thr Gly Asp Thr Thr  Pro Leu Leu Val Thr  Glu Thr Ser 
    3290                 3295                 3300             


Ser Val  Ser Thr Gly His Ala  Thr Pro Leu Leu Val  Thr Asp Ala 
    3305                 3310                 3315             


Ser Ser  Ala Ser Thr Gly His  Ala Thr Pro Leu His  Val Thr Ser 
    3320                 3325                 3330             


Pro Ser  Ser Ala Ser Thr Gly  Asp Thr Thr Pro Val  Pro Val Thr 
    3335                 3340                 3345             


Asp Thr  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3350                 3355                 3360             


Thr Gly  Leu Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Arg Leu Pro 
    3365                 3370                 3375             


Val Thr  Asp Ile Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    3380                 3385                 3390             


Pro Val  Thr Asn Thr Ser Ser  Val Ser Thr Gly Asp  Thr Met Pro 
    3395                 3400                 3405             


Leu Pro  Val Thr Ser Pro Ser  Ser Ala Ser Thr Gly  His Ala Thr 
    3410                 3415                 3420             


Pro Leu  Pro Val Thr Ser Thr  Ser Ser Ala Ser Thr  Gly His Ala 
    3425                 3430                 3435             


Thr Pro  Val Pro Val Thr Ser  Thr Ser Ser Ala Ser  Thr Gly His 
    3440                 3445                 3450             


Thr Thr  Pro Leu Pro Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly 
    3455                 3460                 3465             


Asp Thr  Thr Pro Leu Pro Val  Thr Ser Pro Ser Ser  Ala Ser Thr 
    3470                 3475                 3480             


Gly His  Thr Thr Pro Leu His  Val Thr Ile Pro Ser  Ser Ala Ser 
    3485                 3490                 3495             


Thr Gly  Asp Thr Ser Thr Leu  Pro Val Thr Gly Ala  Ser Ser Ala 
    3500                 3505                 3510             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Asp  Thr Ser Ser 
    3515                 3520                 3525             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Leu Ser 
    3530                 3535                 3540             


Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Ala 
    3545                 3550                 3555             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    3560                 3565                 3570             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Leu Val Thr 
    3575                 3580                 3585             


Asp Ala  Ser Ser Val Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3590                 3595                 3600             


Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Asp Thr Thr  Arg Leu Pro 
    3605                 3610                 3615             


Val Thr  Asp Thr Ser Ser Ala  Ser Thr Gly Gln Ala  Thr Pro Leu 
    3620                 3625                 3630             


Pro Val  Thr Ser Leu Ser Ser  Val Ser Thr Gly Asp  Thr Thr Pro 
    3635                 3640                 3645             


Leu Leu  Val Thr Asp Ala Ser  Ser Val Ser Thr Gly  His Ala Thr 
    3650                 3655                 3660             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Gly Asp Thr 
    3665                 3670                 3675             


Thr Arg  Leu Pro Val Thr Asp  Thr Ser Ser Ala Ser  Thr Gly Gln 
    3680                 3685                 3690             


Ala Thr  Pro Leu Pro Val Thr  Ile Pro Ser Ser Ser  Ser Ser Gly 
    3695                 3700                 3705             


His Thr  Thr Pro Leu Pro Val  Thr Ser Thr Ser Ser  Val Ser Thr 
    3710                 3715                 3720             


Gly His  Val Thr Pro Leu His  Val Thr Ser Pro Ser  Ser Ala Ser 
    3725                 3730                 3735             


Thr Gly  His Val Thr Pro Leu  Pro Val Thr Ser Thr  Ser Ser Ala 
    3740                 3745                 3750             


Ser Thr  Gly His Ala Thr Pro  Leu Leu Val Thr Asp  Ala Ser Ser 
    3755                 3760                 3765             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Asp Ala Ser 
    3770                 3775                 3780             


Ser Ala  Ser Thr Gly Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr 
    3785                 3790                 3795             


Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro Leu Pro  Val Thr Ser 
    3800                 3805                 3810             


Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr Pro Leu  Pro Val Thr 
    3815                 3820                 3825             


Asp Ala  Ser Ser Ala Ser Thr  Gly His Ala Thr Pro  Leu Pro Val 
    3830                 3835                 3840             


Thr Ile  Pro Ser Ser Val Ser  Thr Gly Asp Thr Met  Pro Leu Pro 
    3845                 3850                 3855             


Val Thr  Ser Pro Ser Ser Ala  Ser Thr Gly His Ala  Thr Pro Leu 
    3860                 3865                 3870             


Pro Val  Thr Gly Leu Ser Ser  Ala Ser Thr Gly Asp  Thr Thr Pro 
    3875                 3880                 3885             


Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser Thr Arg  His Ala Thr 
    3890                 3895                 3900             


Pro Leu  Pro Val Thr Asp Thr  Ser Ser Ala Ser Thr  Asp Asp Thr 
    3905                 3910                 3915             


Thr Arg  Leu Pro Val Thr Asp  Val Ser Ser Ala Ser  Thr Gly His 
    3920                 3925                 3930             


Ala Thr  Pro Leu Pro Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly 
    3935                 3940                 3945             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Val Ser Thr 
    3950                 3955                 3960             


Gly His  Ala Thr Ser Leu Pro  Val Thr Ser Arg Ser  Ser Ala Ser 
    3965                 3970                 3975             


Thr Gly  His Ala Thr Pro Leu  Pro Val Thr Asp Thr  Ser Ser Val 
    3980                 3985                 3990             


Ser Thr  Gly His Ala Thr Pro  Leu Pro Val Thr Ser  Thr Ser Ser 
    3995                 4000                 4005             


Val Ser  Thr Gly His Ala Thr  Pro Leu Pro Val Thr  Ser Pro Ser 
    4010                 4015                 4020             


Ser Ala  Ser Thr Gly His Ala  Thr Pro Val Pro Val  Thr Ser Thr 
    4025                 4030                 4035             


Ser Ser  Ala Ser Thr Gly Asp  Thr Thr Pro Leu Pro  Val Thr Asn 
    4040                 4045                 4050             


Ala Ser  Ser Leu Ser Thr Gly  His Ala Thr Pro Leu  His Val Thr 
    4055                 4060                 4065             


Ser Pro  Ser Ser Ala Ser Arg  Gly Asp Thr Ser Thr  Leu Pro Val 
    4070                 4075                 4080             


Thr Asp  Ala Ser Ser Ala Ser  Thr Gly His Ala Thr  Pro Leu Pro 
    4085                 4090                 4095             


Leu Thr  Ser Leu Ser Ser Val  Ser Thr Gly Asp Thr  Thr Pro Leu 
    4100                 4105                 4110             


Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr Gly Gln  Ala Thr Pro 
    4115                 4120                 4125             


Leu Pro  Val Thr Ser Leu Ser  Ser Val Ser Thr Gly  Asp Thr Thr 
    4130                 4135                 4140             


Pro Leu  Pro Val Thr Ile Pro  Ser Ser Ala Ser Ser  Gly His Thr 
    4145                 4150                 4155             


Thr Ser  Leu Pro Val Thr Asp  Ala Ser Ser Val Ser  Thr Gly His 
    4160                 4165                 4170             


Gly Thr  Pro Leu Pro Val Thr  Ser Thr Ser Ser Ala  Ser Thr Gly 
    4175                 4180                 4185             


Asp Thr  Thr Pro Leu Pro Val  Thr Asp Thr Ser Ser  Ala Ser Thr 
    4190                 4195                 4200             


Gly His  Ala Thr Pro Leu Pro  Val Thr Asp Thr Ser  Ser Ala Ser 
    4205                 4210                 4215             


Thr Gly  His Ala Thr Pro Leu  Pro Val Thr Ser Leu  Ser Ser Val 
    4220                 4225                 4230             


Ser Thr  Gly His Ala Thr Pro  Leu Ala Val Ser Ser  Ala Thr Ser 
    4235                 4240                 4245             


Ala Ser  Thr Val Ser Ser Asp  Ser Pro Leu Lys Met  Glu Thr Pro 
    4250                 4255                 4260             


Gly Met  Thr Thr Pro Ser Leu  Lys Thr Asp Gly Gly  Arg Arg Thr 
    4265                 4270                 4275             


Ala Thr  Ser Pro Pro Pro Thr  Thr Ser Gln Thr Ile  Ile Ser Thr 
    4280                 4285                 4290             


Ile Pro  Ser Thr Ala Met His  Thr Arg Ser Thr Ala  Ala Pro Ile 
    4295                 4300                 4305             


Pro Ile  Leu Pro Glu Arg Gly  Val Ser Leu Phe Pro  Tyr Gly Ala 
    4310                 4315                 4320             


Gly Ala  Gly Asp Leu Glu Phe  Val Arg Arg Thr Val  Asp Phe Thr 
    4325                 4330                 4335             


Ser Pro  Leu Phe Lys Pro Ala  Thr Gly Phe Pro Leu  Gly Ser Ser 
    4340                 4345                 4350             


Leu Arg  Asp Ser Leu Tyr Phe  Thr Asp Asn Gly Gln  Ile Ile Phe 
    4355                 4360                 4365             


Pro Glu  Ser Asp Tyr Gln Ile  Phe Ser Tyr Pro Asn  Pro Leu Pro 
    4370                 4375                 4380             


Thr Gly  Phe Thr Gly Arg Asp  Pro Val Ala Leu Val  Ala Pro Phe 
    4385                 4390                 4395             


Trp Asp  Asp Ala Asp Phe Ser  Thr Gly Arg Gly Thr  Thr Phe Tyr 
    4400                 4405                 4410             


Gln Glu  Tyr Glu Thr Phe Tyr  Gly Glu His Ser Leu  Leu Val Gln 
    4415                 4420                 4425             


Gln Ala  Glu Ser Trp Ile Arg  Lys Met Thr Asn Asn  Gly Gly Tyr 
    4430                 4435                 4440             


Lys Ala  Arg Trp Ala Leu Lys  Val Thr Trp Val Asn  Ala His Ala 
    4445                 4450                 4455             


Tyr Pro  Ala Gln Trp Thr Leu  Gly Ser Asn Thr Tyr  Gln Ala Ile 
    4460                 4465                 4470             


Leu Ser  Thr Asp Gly Ser Arg  Ser Tyr Ala Leu Phe  Leu Tyr Gln 
    4475                 4480                 4485             


Ser Gly  Gly Met Gln Trp Asp  Val Ala Gln Arg Ser  Gly Asn Pro 
    4490                 4495                 4500             


Val Leu  Met Gly Phe Ser Ser  Gly Asp Gly Tyr Phe  Glu Asn Ser 
    4505                 4510                 4515             


Pro Leu  Met Ser Gln Pro Val  Trp Glu Arg Tyr Arg  Pro Asp Arg 
    4520                 4525                 4530             


Phe Leu  Asn Ser Asn Ser Gly  Leu Gln Gly Leu Gln  Phe Tyr Arg 
    4535                 4540                 4545             


Leu His  Arg Glu Glu Arg Pro  Asn Tyr Arg Leu Glu  Cys Leu Gln 
    4550                 4555                 4560             


Trp Leu  Lys Ser Gln Pro Arg  Trp Pro Ser Trp Gly  Trp Asn Gln 
    4565                 4570                 4575             


Val Ser  Cys Pro Cys Ser Trp  Gln Gln Gly Arg Arg  Asp Leu Arg 
    4580                 4585                 4590             


Phe Gln  Pro Val Ser Ile Gly  Arg Trp Gly Leu Gly  Ser Arg Gln 
    4595                 4600                 4605             


Leu Cys  Ser Phe Thr Ser Trp  Arg Gly Gly Val Cys  Cys Ser Tyr 
    4610                 4615                 4620             


Gly Pro  Trp Gly Glu Phe Arg  Glu Gly Trp His Val  Gln Arg Pro 
    4625                 4630                 4635             


Trp Gln  Leu Ala Gln Glu Leu  Glu Pro Gln Ser Trp  Cys Cys Arg 
    4640                 4645                 4650             


Trp Asn  Asp Lys Pro Tyr Leu  Cys Ala Leu Tyr Gln  Gln Arg Arg 
    4655                 4660                 4665             


Pro His  Val Gly Cys Ala Thr  Tyr Arg Pro Pro Gln  Pro Ala Trp 
    4670                 4675                 4680             


Met Phe  Gly Asp Pro His Ile  Thr Thr Leu Asp Gly  Val Ser Tyr 
    4685                 4690                 4695             


Thr Phe  Asn Gly Leu Gly Asp  Phe Leu Leu Val Gly  Ala Gln Asp 
    4700                 4705                 4710             


Gly Asn  Ser Ser Phe Leu Leu  Gln Gly Arg Thr Ala  Gln Thr Gly 
    4715                 4720                 4725             


Ser Ala  Gln Ala Thr Asn Phe  Ile Ala Phe Ala Ala  Gln Tyr Arg 
    4730                 4735                 4740             


Ser Ser  Ser Leu Gly Pro Val  Thr Val Gln Trp Leu  Leu Glu Pro 
    4745                 4750                 4755             


His Asp  Ala Ile Arg Val Leu  Leu Asp Asn Gln Thr  Val Thr Phe 
    4760                 4765                 4770             


Gln Pro  Asp His Glu Asp Gly  Gly Gly Gln Glu Thr  Phe Asn Ala 
    4775                 4780                 4785             


Thr Gly  Val Leu Leu Ser Arg  Asn Gly Ser Glu Val  Ser Ala Ser 
    4790                 4795                 4800             


Phe Asp  Gly Trp Ala Thr Val  Ser Val Ile Ala Leu  Ser Asn Ile 
    4805                 4810                 4815             


Leu His  Ala Ser Ala Ser Leu  Pro Pro Glu Tyr Gln  Asn Arg Thr 
    4820                 4825                 4830             


Glu Gly  Leu Leu Gly Val Trp  Asn Asn Asn Pro Glu  Asp Asp Phe 
    4835                 4840                 4845             


Arg Met  Pro Asn Gly Ser Thr  Ile Pro Pro Gly Ser  Pro Glu Glu 
    4850                 4855                 4860             


Met Leu  Phe His Phe Gly Met  Thr Trp Gln Ile Asn  Gly Thr Gly 
    4865                 4870                 4875             


Leu Leu  Gly Lys Arg Asn Asp  Gln Leu Pro Ser Asn  Phe Thr Pro 
    4880                 4885                 4890             


Val Phe  Tyr Ser Gln Leu Gln  Lys Asn Ser Ser Trp  Ala Glu His 
    4895                 4900                 4905             


Leu Ile  Ser Asn Cys Asp Gly  Asp Ser Ser Cys Ile  Tyr Asp Thr 
    4910                 4915                 4920             


Leu Ala  Leu Arg Asn Ala Ser  Ile Gly Leu His Thr  Arg Glu Val 
    4925                 4930                 4935             


Ser Lys  Asn Tyr Glu Gln Ala  Asn Ala Thr Leu Asn  Gln Tyr Pro 
    4940                 4945                 4950             


Pro Ser  Ile Asn Gly Gly Arg  Val Ile Glu Ala Tyr  Lys Gly Gln 
    4955                 4960                 4965             


Thr Thr  Leu Ile Gln Tyr Thr  Ser Asn Ala Glu Asp  Ala Asn Phe 
    4970                 4975                 4980             


Thr Leu  Arg Asp Ser Cys Thr  Asp Leu Glu Leu Phe  Glu Asn Gly 
    4985                 4990                 4995             


Thr Leu  Leu Trp Thr Pro Lys  Ser Leu Glu Pro Phe  Thr Leu Glu 
    5000                 5005                 5010             


Ile Leu  Ala Arg Ser Ala Lys  Ile Gly Leu Ala Ser  Ala Leu Gln 
    5015                 5020                 5025             


Pro Arg  Thr Val Val Cys His  Cys Asn Ala Glu Ser  Gln Cys Leu 
    5030                 5035                 5040             


Tyr Asn  Gln Thr Ser Arg Val  Gly Asn Ser Ser Leu  Glu Val Ala 
    5045                 5050                 5055             


Gly Cys  Lys Cys Asp Gly Gly  Thr Phe Gly Arg Tyr  Cys Glu Gly 
    5060                 5065                 5070             


Ser Glu  Asp Ala Cys Glu Glu  Pro Cys Phe Pro Ser  Val His Cys 
    5075                 5080                 5085             


Val Pro  Gly Lys Gly Cys Glu  Ala Cys Pro Pro Asn  Leu Thr Gly 
    5090                 5095                 5100             


Asp Gly  Arg His Cys Ala Ala  Leu Gly Ser Ser Phe  Leu Cys Gln 
    5105                 5110                 5115             


Asn Gln  Ser Cys Pro Val Asn  Tyr Cys Tyr Asn Gln  Gly His Cys 
    5120                 5125                 5130             


Tyr Ile  Ser Gln Thr Leu Gly  Cys Gln Pro Met Cys  Thr Cys Pro 
    5135                 5140                 5145             


Pro Ala  Phe Thr Asp Ser Arg  Cys Phe Leu Ala Gly  Asn Asn Phe 
    5150                 5155                 5160             


Ser Pro  Thr Val Asn Leu Glu  Leu Pro Leu Arg Val  Ile Gln Leu 
    5165                 5170                 5175             


Leu Leu  Ser Glu Glu Glu Asn  Ala Ser Met Ala Glu  Val Asn Ala 
    5180                 5185                 5190             


Ser Val  Ala Tyr Arg Leu Gly  Thr Leu Asp Met Arg  Ala Phe Leu 
    5195                 5200                 5205             


Arg Asn  Ser Gln Val Glu Arg  Ile Asp Ser Ala Ala  Pro Ala Ser 
    5210                 5215                 5220             


Gly Ser  Pro Ile Gln His Trp  Met Val Ile Ser Glu  Phe Gln Tyr 
    5225                 5230                 5235             


Arg Pro  Arg Gly Pro Val Ile  Asp Phe Leu Asn Asn  Gln Leu Leu 
    5240                 5245                 5250             


Ala Ala  Val Val Glu Ala Phe  Leu Tyr His Val Pro  Arg Arg Ser 
    5255                 5260                 5265             


Glu Glu  Pro Arg Asn Asp Val  Val Phe Gln Pro Ile  Ser Gly Glu 
    5270                 5275                 5280             


Asp Val  Arg Asp Val Thr Ala  Leu Asn Val Ser Thr  Leu Lys Ala 
    5285                 5290                 5295             


Tyr Phe  Arg Cys Asp Gly Tyr  Lys Gly Tyr Asp Leu  Val Tyr Ser 
    5300                 5305                 5310             


Pro Gln  Ser Gly Phe Thr Cys  Val Ser Pro Cys Ser  Arg Gly Tyr 
    5315                 5320                 5325             


Cys Asp  His Gly Gly Gln Cys  Gln His Leu Pro Ser  Gly Pro Arg 
    5330                 5335                 5340             


Cys Ser  Cys Val Ser Phe Ser  Ile Tyr Thr Ala Trp  Gly Glu His 
    5345                 5350                 5355             


Cys Glu  His Leu Ser Met Lys  Leu Asp Ala Phe Phe  Gly Ile Phe 
    5360                 5365                 5370             


Phe Gly  Ala Leu Gly Gly Leu  Leu Leu Leu Gly Val  Gly Thr Phe 
    5375                 5380                 5385             


Val Val  Leu Arg Phe Trp Gly  Cys Ser Gly Ala Arg  Phe Ser Tyr 
    5390                 5395                 5400             


Phe Leu  Asn Ser Ala Glu Ala  Leu Pro 
    5405                 5410         


<210>  151
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Pro Ser Leu Leu Val Leu Thr Phe Ser Pro Cys Val Leu Leu Gly 
1               5                   10                  15      


Trp Ala Leu Leu Ala Gly Gly Thr Gly Gly Gly Gly Val Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ile Gly Gly Gly Arg Gln Glu Arg Glu Ala Leu 
        35                  40                  45              


Pro Pro Gln Lys Ile Glu Val Leu Val Leu Leu Pro Gln Asp Asp Ser 
    50                  55                  60                  


Tyr Leu Phe Ser Leu Thr Arg Val Arg Pro Ala Ile Glu Tyr Ala Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gly Asn Gly Thr Gly Arg Arg Leu Leu Pro Pro Gly 
                85                  90                  95      


Thr Arg Phe Gln Val Ala Tyr Glu Asp Ser Asp Cys Gly Asn Arg Ala 
            100                 105                 110         


Leu Phe Ser Leu Val Asp Arg Val Ala Ala Ala Arg Gly Ala Lys Pro 
        115                 120                 125             


Asp Leu Ile Leu Gly Pro Val Cys Glu Tyr Ala Ala Ala Pro Val Ala 
    130                 135                 140                 


Arg Leu Ala Ser His Trp Asp Leu Pro Met Leu Ser Ala Gly Ala Leu 
145                 150                 155                 160 


Ala Ala Gly Phe Gln His Lys Asp Ser Glu Tyr Ser His Leu Thr Arg 
                165                 170                 175     


Val Ala Pro Ala Tyr Ala Lys Met Gly Glu Met Met Leu Ala Leu Phe 
            180                 185                 190         


Arg His His His Trp Ser Arg Ala Ala Leu Val Tyr Ser Asp Asp Lys 
        195                 200                 205             


Leu Glu Arg Asn Cys Tyr Phe Thr Leu Glu Gly Val His Glu Val Phe 
    210                 215                 220                 


Gln Glu Glu Gly Leu His Thr Ser Ile Tyr Ser Phe Asp Glu Thr Lys 
225                 230                 235                 240 


Asp Leu Asp Leu Glu Asp Ile Val Arg Asn Ile Gln Ala Ser Glu Arg 
                245                 250                 255     


Val Val Ile Met Cys Ala Ser Ser Asp Thr Ile Arg Ser Ile Met Leu 
            260                 265                 270         


Val Ala His Arg His Gly Met Thr Ser Gly Asp Tyr Ala Phe Phe Asn 
        275                 280                 285             


Ile Glu Leu Phe Asn Ser Ser Ser Tyr Gly Asp Gly Ser Trp Lys Arg 
    290                 295                 300                 


Gly Asp Lys His Asp Phe Glu Ala Lys Gln Ala Tyr Ser Ser Leu Gln 
305                 310                 315                 320 


Thr Val Thr Leu Leu Arg Thr Val Lys Pro Glu Phe Glu Lys Phe Ser 
                325                 330                 335     


Met Glu Val Lys Ser Ser Val Glu Lys Gln Gly Leu Asn Met Glu Asp 
            340                 345                 350         


Tyr Val Asn Met Phe Val Glu Gly Phe His Asp Ala Ile Leu Leu Tyr 
        355                 360                 365             


Val Leu Ala Leu His Glu Val Leu Arg Ala Gly Tyr Ser Lys Lys Asp 
    370                 375                 380                 


Gly Gly Lys Ile Ile Gln Gln Thr Trp Asn Arg Thr Phe Glu Gly Ile 
385                 390                 395                 400 


Ala Gly Gln Val Ser Ile Asp Ala Asn Gly Asp Arg Tyr Gly Asp Phe 
                405                 410                 415     


Ser Val Ile Ala Met Thr Asp Val Glu Ala Gly Thr Gln Glu Val Ile 
            420                 425                 430         


Gly Asp Tyr Phe Gly Lys Glu Gly Arg Phe Glu Met Arg Pro Asn Val 
        435                 440                 445             


Lys Tyr Pro Trp Gly Pro Leu Lys Leu Arg Ile Asp Glu Asn Arg Ile 
    450                 455                 460                 


Val Glu His Thr Asn Ser Ser Pro Cys Lys Ser Ser Gly Gly Leu Glu 
465                 470                 475                 480 


Glu Ser Ala Val Thr Gly Ile Val Val Gly Ala Leu Leu Gly Ala Gly 
                485                 490                 495     


Leu Leu Met Ala Phe Tyr Phe Phe Arg Lys Lys Tyr Arg Ile Thr Ile 
            500                 505                 510         


Glu Arg Arg Thr Gln Gln Glu Glu Ser Asn Leu Gly Lys His Arg Glu 
        515                 520                 525             


Leu Arg Glu Asp Ser Ile Arg Ser His Phe Ser Val Ala 
    530                 535                 540     


<210>  152
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr 
1               5                   10                  15      


Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe 
            20                  25                  30          


Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu 
        35                  40                  45              


Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val 
    50                  55                  60                  


Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val 
65                  70                  75                  80  


Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro 
            100                 105                 110         


Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe 
        115                 120                 125             


Ile Phe Gly Thr Ser Arg His Ile Ser Val Gly Pro Phe Pro Val Val 
    130                 135                 140                 


Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His 
145                 150                 155                 160 


Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile 
                165                 170                 175     


Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu 
            180                 185                 190         


Thr Leu Leu Val Gly Ile Ile Gln Leu Ile Phe Gly Gly Leu Gln Ile 
        195                 200                 205             


Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr 
    210                 215                 220                 


Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu 
225                 230                 235                 240 


Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr 
                245                 250                 255     


Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe 
            260                 265                 270         


Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu 
        275                 280                 285             


Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val 
    290                 295                 300                 


Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu 
305                 310                 315                 320 


Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu 
                325                 330                 335     


Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala 
            340                 345                 350         


Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly 
        355                 360                 365             


Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu 
    370                 375                 380                 


Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys 
385                 390                 395                 400 


Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr 
                405                 410                 415     


Gly Gly Lys Thr Gln Val Ala Gly Ile Ile Ser Ala Ala Ile Val Met 
            420                 425                 430         


Ile Ala Ile Leu Ala Leu Gly Lys Leu Leu Glu Pro Leu Gln Lys Ser 
        435                 440                 445             


Val Leu Ala Ala Val Val Ile Ala Asn Leu Lys Gly Met Phe Met Gln 
    450                 455                 460                 


Leu Cys Asp Ile Pro Arg Leu Trp Arg Gln Asn Lys Ile Asp Ala Val 
465                 470                 475                 480 


Ile Trp Val Phe Thr Cys Ile Val Ser Ile Ile Leu Gly Leu Asp Leu 
                485                 490                 495     


Gly Leu Leu Ala Gly Leu Ile Phe Gly Leu Leu Thr Val Val Leu Arg 
            500                 505                 510         


Val Gln Phe Pro Ser Trp Asn Gly Leu Gly Ser Ile Pro Ser Thr Asp 
        515                 520                 525             


Ile Tyr Lys Ser Thr Lys Asn Tyr Lys Asn Ile Glu Glu Pro Gln Gly 
    530                 535                 540                 


Val Lys Ile Leu Arg Phe Ser Ser Pro Ile Phe Tyr Gly Asn Val Asp 
545                 550                 555                 560 


Gly Phe Lys Lys Cys Ile Lys Ser Thr Val Gly Phe Asp Ala Ile Arg 
                565                 570                 575     


Val Tyr Asn Lys Arg Leu Lys Ala Leu Arg Lys Ile Gln Lys Leu Ile 
            580                 585                 590         


Lys Ser Gly Gln Leu Arg Ala Thr Lys Asn Gly Ile Ile Ser Asp Ala 
        595                 600                 605             


Val Ser Thr Asn Asn Ala Phe Glu Pro Asp Glu Asp Ile Glu Asp Leu 
    610                 615                 620                 


Glu Glu Leu Asp Ile Pro Thr Lys Glu Ile Glu Ile Gln Val Asp Trp 
625                 630                 635                 640 


Asn Ser Glu Leu Pro Val Lys Val Asn Val Pro Lys Val Pro Ile His 
                645                 650                 655     


Ser Leu Val Leu Asp Cys Gly Ala Ile Ser Phe Leu Asp Val Val Gly 
            660                 665                 670         


Val Arg Ser Leu Arg Val Ile Val Lys Glu Phe Gln Arg Ile Asp Val 
        675                 680                 685             


Asn Val Tyr Phe Ala Ser Leu Gln Asp Tyr Val Ile Glu Lys Leu Glu 
    690                 695                 700                 


Gln Cys Gly Phe Phe Asp Asp Asn Ile Arg Lys Asp Thr Phe Phe Leu 
705                 710                 715                 720 


Thr Val His Asp Ala Ile Leu Tyr Leu Gln Asn Gln Val Lys Ser Gln 
                725                 730                 735     


Glu Gly Gln Gly Ser Ile Leu Glu Thr Ile Thr Leu Ile Gln Asp Cys 
            740                 745                 750         


Lys Asp Thr Leu Glu Leu Ile Glu Thr Glu Leu Thr Glu Glu Glu Leu 
        755                 760                 765             


Asp Val Gln Asp Glu Ala Met Arg Thr Leu Ala Ser 
    770                 775                 780 


<210>  153
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
1               5                   10                  15      


Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
            20                  25                  30          


Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
        35                  40                  45              


Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
    50                  55                  60                  


Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Ile Glu Asn Thr Glu 
65                  70                  75                  80  


Ala Val His Gln Gln Phe Gln Lys Phe Leu Thr Glu Ile Ser Lys Leu 
                85                  90                  95      


Thr Asn Asp Tyr Glu Leu Asn Ile Thr Asn Arg Leu Phe Gly Glu Lys 
            100                 105                 110         


Thr Tyr Leu Phe Leu Gln Lys Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr 
        115                 120                 125             


His Ala Ser Leu Glu Pro Val Asp Phe Val Asn Ala Ala Asp Glu Ser 
    130                 135                 140                 


Arg Lys Lys Ile Asn Ser Trp Val Glu Ser Lys Thr Asn Glu Lys Ile 
145                 150                 155                 160 


Lys Asp Leu Phe Pro Asp Gly Ser Ile Ser Ser Ser Thr Lys Leu Val 
                165                 170                 175     


Leu Val Asn Met Val Tyr Phe Lys Gly Gln Trp Asp Arg Glu Phe Lys 
            180                 185                 190         


Lys Glu Asn Thr Lys Glu Glu Lys Phe Trp Met Asn Lys Ser Thr Ser 
        195                 200                 205             


Lys Ser Val Gln Met Met Thr Gln Ser His Ser Phe Ser Phe Thr Phe 
    210                 215                 220                 


Leu Glu Asp Leu Gln Ala Lys Ile Leu Gly Ile Pro Tyr Lys Asn Asn 
225                 230                 235                 240 


Asp Leu Ser Met Phe Val Leu Leu Pro Asn Asp Ile Asp Gly Leu Glu 
                245                 250                 255     


Lys Ile Ile Asp Lys Ile Ser Pro Glu Lys Leu Val Glu Trp Thr Ser 
            260                 265                 270         


Pro Gly His Met Glu Glu Arg Lys Val Asn Leu His Leu Pro Arg Phe 
        275                 280                 285             


Glu Val Glu Asp Gly Tyr Asp Leu Glu Ala Val Leu Ala Ala Met Gly 
    290                 295                 300                 


Met Gly Asp Ala Phe Ser Glu His Lys Ala Asp Tyr Ser Gly Met Ser 
305                 310                 315                 320 


Ser Gly Ser Gly Leu Tyr Ala Gln Lys Phe Leu His Ser Ser Phe Val 
                325                 330                 335     


Ala Val Thr Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Gly 
            340                 345                 350         


Phe Thr Val Thr Ser Ala Pro Gly His Glu Asn Val His Cys Asn His 
        355                 360                 365             


Pro Phe Leu Phe Phe Ile Arg His Asn Glu Ser Asn Ser Ile Leu Phe 
    370                 375                 380                 


Phe Gly Arg Phe Ser Ser Pro 
385                 390     


<210>  154
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
            740                 745                 


<210>  155
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Leu Val Phe Arg Thr Val Ala Gln Leu Ala Gly Val Ser Leu 
1               5                   10                  15      


Ser Leu Leu Gly Trp Val Leu Ser Cys Leu Thr Asn Tyr Leu Pro His 
            20                  25                  30          


Trp Lys Asn Leu Asn Leu Asp Leu Asn Glu Met Glu Asn Trp Thr Met 
        35                  40                  45              


Gly Leu Trp Gln Thr Cys Val Ile Gln Glu Glu Val Gly Met Gln Cys 
    50                  55                  60                  


Lys Asp Phe Asp Ser Phe Leu Ala Leu Pro Ala Glu Leu Arg Val Ser 
65                  70                  75                  80  


Arg Ile Leu Met Phe Leu Ser Asn Gly Leu Gly Phe Leu Gly Leu Leu 
                85                  90                  95      


Val Ser Gly Phe Gly Leu Asp Cys Leu Arg Ile Gly Glu Ser Gln Arg 
            100                 105                 110         


Asp Leu Lys Arg Arg Leu Leu Ile Leu Gly Gly Ile Leu Ser Trp Ala 
        115                 120                 125             


Ser Gly Val Thr Ala Leu Val Pro Val Ser Trp Val Ala His Lys Thr 
    130                 135                 140                 


Val Gln Glu Phe Trp Asp Glu Asn Val Pro Asp Phe Val Pro Arg Trp 
145                 150                 155                 160 


Glu Phe Gly Glu Ala Leu Phe Leu Gly Trp Phe Ala Gly Leu Ser Leu 
                165                 170                 175     


Leu Leu Gly Gly Cys Leu Leu His Cys Ala Ala Cys Ser Ser His Ala 
            180                 185                 190         


Pro Leu Ala Ser Gly His Tyr Ala Val Ala Gln Thr Gln Asp His His 
        195                 200                 205             


Gln Glu Leu Glu Thr Arg Asn Thr Asn Leu Lys His 
    210                 215                 220 


<210>  156
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu 
1               5                   10                  15      


Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro 
            20                  25                  30          


Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu 
        35                  40                  45              


Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp 
    50                  55                  60                  


Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser 
65                  70                  75                  80  


Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala 
                85                  90                  95      


Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser 
            100                 105                 110         


Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe 
        115                 120                 125             


Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala 
    130                 135                 140                 


Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr 
145                 150                 155                 160 


Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His 
                165                 170                 175     


Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn 
            180                 185                 190         


Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp 
        195                 200                 205             


Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe 
    210                 215                 220                 


Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr 
225                 230                 235                 240 


Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp 
                245                 250                 255     


Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile 
            260                 265                 270         


Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Phe Glu 
        275                 280                 285             


Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu 
    290                 295                 300                 


Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala 
305                 310                 315                 320 


Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly 
                325                 330                 335     


Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu 
            340                 345                 350         


Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr 
        355                 360                 365             


His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro 
    370                 375                 380                 


Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg 
385                 390                 395                 400 


Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr 
                405                 410                 415     


Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser 
            420                 425                 430         


Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro 
        435                 440                 445             


Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg 
    450                 455                 460                 


His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp 
465                 470                 475                 480 


Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val 
                485                 490                 495     


Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg 
            500                 505                 510         


Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys 
        515                 520                 525             


Thr His 
    530 


<210>  157
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Ser Gly Glu Ser Gly Gln Pro Glu Ala Gly Pro Ser His Ala Gly 
1               5                   10                  15      


Leu Asp Trp Pro Asn Pro Glu Arg Asn Arg Ala Gly Val Pro Gly Gly 
            20                  25                  30          


Val Ile Arg Arg Ala Gly Ser Gln Gly Pro Arg Ser Trp Ile Gln Lys 
        35                  40                  45              


Val Leu Glu Gln Ile Met Asp Ser Pro Arg Gln Cys Val Thr Pro Ser 
    50                  55                  60                  


Glu Val Val Pro Val Thr Val Leu Ala Val Gln Arg Tyr Leu Leu Glu 
65                  70                  75                  80  


Asp Glu Pro Arg Asp Thr Val Pro Lys Pro Pro Leu Tyr Cys Tyr Asp 
                85                  90                  95      


Val Thr Ile Ser Asp Gly Val Tyr Gln Glu Lys Cys Tyr Leu Asp Pro 
            100                 105                 110         


Ser Leu Asn Ser Leu Val Tyr Gln Asn Ile Leu Lys Val Gly Ile Gln 
        115                 120                 125             


Met Arg Ile Ser Arg Val Ser Cys Leu Tyr Asn Glu Lys Arg Ile Gly 
    130                 135                 140                 


Gln Gly Ile Leu Cys Ile Asp Asn Val His Cys Gly Glu Thr Ser Asp 
145                 150                 155                 160 


Ser Ile Ser Leu Glu Thr Pro Phe Arg Asn Arg Ala His Gln Glu Lys 
                165                 170                 175     


Pro Glu Arg Pro Leu Arg Gly Gly Lys Ser His Tyr Leu Ala Leu Trp 
            180                 185                 190         


Asn Asn Glu Asp Pro Tyr Gly Asp Ile Trp Leu Thr Asp Lys Gln Pro 
        195                 200                 205             


Glu Glu His Asn Phe Ser Asp Thr Lys Ile Ile Ser Leu Ser His Leu 
    210                 215                 220                 


Glu Met Thr Trp Thr Asn Arg Arg Asn Phe Pro Ala Leu Leu Val Arg 
225                 230                 235                 240 


Ile Leu His Lys Ser Lys Leu Arg Tyr Tyr Gly Lys Pro Asp Lys Lys 
                245                 250                 255     


Met Ile Glu Pro Tyr Gln Thr Phe Leu Glu Val Ala Asp Ser Ser Gly 
            260                 265                 270         


Thr Val Ser Val Ile Met Trp Asn Ala Leu Cys Pro Glu Trp Tyr Lys 
        275                 280                 285             


Ser Leu Arg Val Gly Leu Val Leu Leu Leu Gln Asp Tyr Ser Val Lys 
    290                 295                 300                 


Lys Ser Tyr Pro Phe Arg Ile Gln Pro Val Pro Val Asp Pro Gln Ile 
305                 310                 315                 320 


Lys Leu Ile Ser Thr Met Glu Ile Cys Leu Asn Leu Arg Asp Pro Pro 
                325                 330                 335     


Thr Asn Ile Ile Ile Ile Pro Glu Lys Gln Val Lys Pro Glu Trp Arg 
            340                 345                 350         


Leu Pro Lys Leu Asn His Arg Phe Thr Thr Arg Ser Glu Leu Asp Asp 
        355                 360                 365             


Met Pro Glu Asn Cys Ile Cys Asp Val Ile Gly Leu Leu Val Phe Val 
    370                 375                 380                 


Gly Arg Val Gln Arg Ser Lys Lys Lys Glu Asn Arg Glu Asp Phe Trp 
385                 390                 395                 400 


Ser Tyr Arg Trp Ile His Ile Ala Asp Gly Thr Ser Glu Gln Pro Phe 
                405                 410                 415     


Ile Val Glu Leu Phe Ser Thr Ser Gln Pro Glu Ile Phe Glu Asn Ile 
            420                 425                 430         


Tyr Pro Met Ala Tyr Phe Val Cys Thr Gln Leu Lys Val Val Arg Asn 
        435                 440                 445             


Asp Asn Gln Val Pro Lys Leu Leu Tyr Leu Thr Thr Thr Asn Glu Ser 
    450                 455                 460                 


Gly Val Phe Ile Thr Gly His Arg Gly Gln Pro Tyr Thr Tyr Asp Ala 
465                 470                 475                 480 


Lys Val Lys Asn Phe Ile Gln Trp Ile Arg Thr Lys Ser Asp Ser Gly 
                485                 490                 495     


Glu Gln Lys Asn Met Val Ile Gly Gly Tyr Tyr Pro Tyr Pro Pro Val 
            500                 505                 510         


Pro Glu Thr Phe Ser Lys Tyr Ser Ser Ser Ile Lys Val Glu Ser Leu 
        515                 520                 525             


Leu Thr Ala Ile Ser Glu Val Arg Lys Glu Ile Glu Asp Leu Gln Tyr 
    530                 535                 540                 


Arg Glu Gln Lys Arg Ile Ala Ile Gln Gly Ile Ile Thr Ala Ile Lys 
545                 550                 555                 560 


Tyr Ile Pro His Ser Ser Ala Thr Glu Ser Ala Ser Ala Ser Glu Thr 
                565                 570                 575     


Leu Arg Asn Ala Asn Arg Pro Ser Thr Ser Gln Ala Ala Arg Val Glu 
            580                 585                 590         


Ile Gln Glu Arg Asn Gly Lys Arg His Gln Asp Asp Glu Pro Val Asn 
        595                 600                 605             


Ser Gln Tyr Phe Gln Thr Thr Ser Thr Asn Leu Ser Leu Ser Asn Lys 
    610                 615                 620                 


Ile Arg Ile Leu Gln Gly Pro His Ala Asn Pro Val Ala Val Pro Gln 
625                 630                 635                 640 


Pro Gly Ala Ser Val Gln Thr Lys Gly Ile Lys Pro Gly Met Pro Ser 
                645                 650                 655     


Ile Phe Asn Arg Arg Ala Asn Ile Asn Ala Asn Leu Gln Gly Lys Ala 
            660                 665                 670         


Arg Lys Thr Ile Ser Asp Arg Trp Glu Ser Gln Leu Trp Arg Glu Lys 
        675                 680                 685             


Lys Phe Gly Leu Ile Asp His Leu His Tyr Ser Arg Val Tyr Pro Glu 
    690                 695                 700                 


Ser Ile Pro Arg Lys Phe Met Phe Glu His Arg Lys Phe Leu Ser Asp 
705                 710                 715                 720 


Gln Tyr Asn Ser Gln Pro Ala Lys Tyr Val Pro Pro Glu Gly Arg Pro 
                725                 730                 735     


Pro Lys Leu Asp Asp Phe Lys Ser Ala Arg Ser Leu Gly His Phe Glu 
            740                 745                 750         


Val Thr Ile Leu Gly Leu Asn His Glu Ile Ala Ile Asp Val Ala Phe 
        755                 760                 765             


Leu Pro Met Tyr Cys Pro Glu Asp Ile Arg Thr Ser Gln Ile Asp Thr 
    770                 775                 780                 


Leu Leu Thr Ser Met Asn Tyr Ser Cys Ala Tyr Pro Gln Asp Thr Thr 
785                 790                 795                 800 


Gly Asn Asp Arg Leu Pro Gly Pro Arg Ala Val Ala Gly Asp Ile Ile 
                805                 810                 815     


Lys Ala Ala Thr Glu Leu Asp Arg Val His Ile Val Gly Ile Leu Asp 
            820                 825                 830         


Ile Cys Asn Leu Gly Asn Asn Lys Val Glu Val Tyr Leu His Lys Ile 
        835                 840                 845             


Tyr Ser Pro Glu Asn Thr Ser 
    850                 855 


<210>  158
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Arg Leu Ser Ala Gly Pro Asp Ala Gly Pro Ser Gly Asn Ser Ser 
1               5                   10                  15      


Pro Trp Trp Pro Leu Ala Thr Gly Ala Gly Asn Thr Ser Arg Glu Ala 
            20                  25                  30          


Glu Ala Leu Gly Glu Gly Asn Gly Pro Pro Arg Asp Val Arg Asn Glu 
        35                  40                  45              


Glu Leu Ala Lys Leu Glu Ile Ala Val Leu Ala Val Thr Phe Ala Val 
    50                  55                  60                  


Ala Val Leu Gly Asn Ser Ser Val Leu Leu Ala Leu His Arg Thr Pro 
65                  70                  75                  80  


Arg Lys Thr Ser Arg Met His Leu Phe Ile Arg His Leu Ser Leu Ala 
                85                  90                  95      


Asp Leu Ala Val Ala Phe Phe Gln Val Leu Pro Gln Met Cys Trp Asp 
            100                 105                 110         


Ile Thr Tyr Arg Phe Arg Gly Pro Asp Trp Leu Cys Arg Val Val Lys 
        115                 120                 125             


His Leu Gln Val Phe Gly Met Phe Ala Ser Ala Tyr Met Leu Val Val 
    130                 135                 140                 


Met Thr Ala Asp Arg Tyr Ile Ala Val Cys His Pro Leu Lys Thr Leu 
145                 150                 155                 160 


Gln Gln Pro Ala Arg Arg Ser Arg Leu Met Ile Ala Ala Ala Trp Val 
                165                 170                 175     


Leu Ser Phe Val Leu Ser Thr Pro Gln Tyr Phe Val Phe Ser Met Ile 
            180                 185                 190         


Glu Val Asn Asn Val Thr Lys Ala Arg Asp Cys Trp Ala Thr Phe Ile 
        195                 200                 205             


Gln Pro Trp Gly Ser Arg Ala Tyr Val Thr Trp Met Thr Gly Gly Ile 
    210                 215                 220                 


Phe Val Ala Pro Val Val Ile Leu Gly Thr Cys Tyr Gly Phe Ile Cys 
225                 230                 235                 240 


Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Thr Ala Ser Arg Gln Ser 
                245                 250                 255     


Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln Lys Gly Phe Leu Leu 
            260                 265                 270         


Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser Arg Ala Lys Ile Arg 
        275                 280                 285             


Thr Val Lys Met Thr Phe Val Ile Val Thr Ala Tyr Ile Val Cys Trp 
    290                 295                 300                 


Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val Trp Asp Pro Met Ser 
305                 310                 315                 320 


Val Trp Thr Glu Ser Glu Asn Pro Thr Ile Thr Ile Thr Ala Leu Leu 
                325                 330                 335     


Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile Tyr Met Phe Phe Ser 
            340                 345                 350         


Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe Pro Cys Cys Gln Asn 
        355                 360                 365             


Met Lys Glu Lys Phe Asn Lys Glu Asp Thr Asp Ser Met Ser Arg Arg 
    370                 375                 380                 


Gln Thr Phe Tyr Ser Asn Asn Arg Ser Pro Thr Asn Ser Thr Gly Met 
385                 390                 395                 400 


Trp Lys Asp Ser Pro Lys Ser Ser Lys Ser Ile Lys Phe Ile Pro Val 
                405                 410                 415     


Ser Thr 
        


<210>  159
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Leu Ser Val Gln Pro Asp Thr Lys Pro Lys Gly Cys Ala Gly Cys 
1               5                   10                  15      


Asn Arg Lys Ile Lys Asp Arg Tyr Leu Leu Lys Ala Leu Asp Lys Tyr 
            20                  25                  30          


Trp His Glu Asp Cys Leu Lys Cys Ala Cys Cys Asp Cys Arg Leu Gly 
        35                  40                  45              


Glu Val Gly Ser Thr Leu Tyr Thr Lys Ala Asn Leu Ile Leu Cys Arg 
    50                  55                  60                  


Arg Asp Tyr Leu Arg Leu Phe Gly Val Thr Gly Asn Cys Ala Ala Cys 
65                  70                  75                  80  


Ser Lys Leu Ile Pro Ala Phe Glu Met Val Met Arg Ala Lys Asp Asn 
                85                  90                  95      


Val Tyr His Leu Asp Cys Phe Ala Cys Gln Leu Cys Asn Gln Arg Phe 
            100                 105                 110         


Cys Val Gly Asp Lys Phe Phe Leu Lys Asn Asn Met Ile Leu Cys Gln 
        115                 120                 125             


Thr Asp Tyr Glu Glu Gly Leu Met Lys Glu Gly Tyr Ala Pro Gln Val 
    130                 135                 140                 


Arg 
145 


<210>  160
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Pro Ser Met Leu Glu Arg Ile Ser Lys Asn Leu Val Lys Glu Ile 
1               5                   10                  15      


Gly Ser Lys Asp Leu Thr Pro Val Lys Tyr Leu Leu Ser Ala Thr Lys 
            20                  25                  30          


Leu Arg Gln Phe Val Ile Leu Arg Lys Lys Lys Asp Ser Arg Ser Ser 
        35                  40                  45              


Phe Trp Glu Gln Ser Asp Tyr Val Pro Val Glu Phe Ser Leu Asn Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ser Ser Val Leu Glu Thr Val Val Thr Gly Pro 
65                  70                  75                  80  


Phe His Phe Ser Asp Ile Met Ile Gln Lys His Lys Ala Asp Met Gly 
                85                  90                  95      


Val Asn Val Gly Ile Glu Val Ser Val Ser Gly Glu Ala Ser Val Asp 
            100                 105                 110         


His Gly Cys Ser Leu Glu Phe Gln Ile Val Thr Ile Pro Ser Pro Asn 
        115                 120                 125             


Leu Glu Asp Phe Gln Lys Arg Lys Leu Leu Asp Pro Glu Pro Ser Phe 
    130                 135                 140                 


Leu Lys Glu Cys Arg Arg Arg Gly Asp Asn Leu Tyr Val Val Thr Glu 
145                 150                 155                 160 


Ala Val Glu Leu Ile Asn Asn Thr Val Leu Tyr Asp Ser Ser Ser Val 
                165                 170                 175     


Asn Ile Leu Gly Lys Ile Ala Leu Trp Ile Thr Tyr Gly Lys Gly Gln 
            180                 185                 190         


Gly Gln Gly Glu Ser Leu Arg Val Lys Lys Lys Ala Leu Thr Leu Gln 
        195                 200                 205             


Lys Gly Met Val Met Ala Tyr Lys Arg Lys Gln Leu Val Ile Lys Glu 
    210                 215                 220                 


Lys Ala Ile Leu Ile Ser Asp Asp Asp Glu Gln Arg Thr Phe Gln Asp 
225                 230                 235                 240 


Glu Tyr Glu Ile Ser Glu Met Val Gly Tyr Cys Ala Ala Arg Ser Glu 
                245                 250                 255     


Gly Leu Leu Pro Ser Phe His Thr Ile Ser Pro Thr Leu Phe Asn Ala 
            260                 265                 270         


Ser Ser Asn Asp Met Lys Leu Lys Pro Glu Leu Phe Leu Thr Gln Gln 
        275                 280                 285             


Phe Leu Ser Gly His Leu Pro Lys Tyr Glu Gln Val His Ile Leu Pro 
    290                 295                 300                 


Val Gly Arg Ile Glu Glu Pro Phe Trp Gln Asn Phe Lys His Leu Gln 
305                 310                 315                 320 


Glu Glu Val Phe Gln Lys Ile Lys Thr Leu Ala Gln Leu Ser Lys Asp 
                325                 330                 335     


Val Gln Asp Val Met Phe Tyr Ser Ile Leu Ala Met Leu Arg Asp Arg 
            340                 345                 350         


Gly Ala Leu Gln Asp Leu Met Asn Met Leu Glu Leu Asp Ser Ser Gly 
        355                 360                 365             


His Leu Asp Gly Pro Gly Gly Ala Ile Leu Lys Lys Leu Gln Gln Asp 
    370                 375                 380                 


Ser Asn His Ala Trp Phe Asn Pro Lys Asp Pro Ile Leu Tyr Leu Leu 
385                 390                 395                 400 


Glu Ala Ile Met Val Leu Ser Asp Phe Gln His Asp Leu Leu Ala Cys 
                405                 410                 415     


Ser Met Glu Lys Arg Ile Leu Leu Gln Gln Gln Glu Leu Val Arg Ser 
            420                 425                 430         


Ile Leu Glu Pro Asn Phe Arg Tyr Pro Trp Ser Ile Pro Phe Thr Leu 
        435                 440                 445             


Lys Pro Glu Leu Leu Ala Pro Leu Gln Ser Glu Gly Leu Ala Ile Thr 
    450                 455                 460                 


Tyr Gly Leu Leu Glu Glu Cys Gly Leu Arg Met Glu Leu Asp Asn Pro 
465                 470                 475                 480 


Arg Ser Thr Trp Asp Val Glu Ala Lys Met Pro Leu Ser Ala Leu Tyr 
                485                 490                 495     


Gly Thr Leu Ser Leu Leu Gln Gln Leu Ala Glu Ala 
            500                 505             


<210>  161
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Lys Ala Ile Ile His Leu Thr Leu Leu Ala Leu Leu Ser Val Asn 
1               5                   10                  15      


Thr Ala Thr Asn Gln Gly Asn Ser Ala Asp Ala Val Thr Thr Thr Glu 
            20                  25                  30          


Thr Ala Thr Ser Gly Pro Thr Val Ala Ala Ala Asp Thr Thr Glu Thr 
        35                  40                  45              


Asn Phe Pro Glu Thr Ala Ser Thr Thr Ala Asn Thr Pro Ser Phe Pro 
    50                  55                  60                  


Thr Ala Thr Ser Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
65                  70                  75                  80  


Thr Ile Pro Thr Pro Ala Pro Pro Ile Ile Ser Thr His Ser Ser Ser 
                85                  90                  95      


Thr Ile Pro Ile Pro Thr Ala Ala Asp Ser Glu Ser Thr Thr Asn Val 
            100                 105                 110         


Asn Ser Leu Ala Thr Ser Asp Ile Ile Thr Ala Ser Ser Pro Asn Asp 
        115                 120                 125             


Gly Leu Ile Thr Met Val Pro Ser Glu Thr Gln Ser Asn Asn Glu Met 
    130                 135                 140                 


Ser Pro Thr Thr Glu Asp Asn Gln Ser Ser Gly Pro Pro Thr Gly Thr 
145                 150                 155                 160 


Ala Leu Leu Glu Thr Ser Thr Leu Asn Ser Thr Gly Pro Ser Asn Pro 
                165                 170                 175     


Cys Gln Asp Asp Pro Cys Ala Asp Asn Ser Leu Cys Val Lys Leu His 
            180                 185                 190         


Asn Thr Ser Phe Cys Leu Cys Leu Glu Gly Tyr Tyr Tyr Asn Ser Ser 
        195                 200                 205             


Thr Cys Lys Lys Gly Lys Val Phe Pro Gly Lys Ile Ser Val Thr Val 
    210                 215                 220                 


Ser Glu Thr Phe Asp Pro Glu Glu Lys His Ser Met Ala Tyr Gln Asp 
225                 230                 235                 240 


Leu His Ser Glu Ile Thr Ser Leu Phe Lys Asp Val Phe Gly Thr Ser 
                245                 250                 255     


Val Tyr Gly Gln Thr Val Ile Leu Thr Val Ser Thr Ser Leu Ser Pro 
            260                 265                 270         


Arg Ser Glu Met Arg Ala Asp Asp Lys Phe Val Asn Val Thr Ile Val 
        275                 280                 285             


Thr Ile Leu Ala Glu Thr Thr Ser Asp Asn Glu Lys Thr Val Thr Glu 
    290                 295                 300                 


Lys Ile Asn Lys Ala Ile Arg Ser Ser Ser Ser Asn Phe Leu Asn Tyr 
305                 310                 315                 320 


Asp Leu Thr Leu Arg Cys Asp Tyr Tyr Gly Cys Asn Gln Thr Ala Asp 
                325                 330                 335     


Asp Cys Leu Asn Gly Leu Ala Cys Asp Cys Lys Ser Asp Leu Gln Arg 
            340                 345                 350         


Pro Asn Pro Gln Ser Pro Phe Cys Val Ala Ser Ser Leu Lys Cys Pro 
        355                 360                 365             


Asp Ala Cys Asn Ala Gln His Lys Gln Cys Leu Ile Lys Lys Ser Gly 
    370                 375                 380                 


Gly Ala Pro Glu Cys Ala Cys Val Pro Gly Tyr Gln Glu Asp Ala Asn 
385                 390                 395                 400 


Gly Asn Cys Gln Lys Cys Ala Phe Gly Tyr Ser Gly Leu Asp Cys Lys 
                405                 410                 415     


Asp Lys Phe Gln Leu Ile Leu Thr Ile Val Gly Thr Ile Ala Gly Ile 
            420                 425                 430         


Val Ile Leu Ser Met Ile Ile Ala Leu Ile Val Thr Ala Arg Ser Asn 
        435                 440                 445             


Asn Lys Thr Lys His Ile Glu Glu Glu Asn Leu Ile Asp Glu Asp Phe 
    450                 455                 460                 


Gln Asn Leu Lys Leu Arg Ser Thr Gly Phe Thr Asn Leu Gly Ala Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Lys Val Arg Ile Thr Ala Ser Arg Asp Ser Gln 
                485                 490                 495     


Met Gln Asn Pro Tyr Ser Arg His Ser Ser Met Pro Arg Pro Asp Tyr 
            500                 505                 510         


<210>  162
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Lys Ala Lys Arg Ser His Gln Ala Ile Ile Met Ser Thr Ser Leu 
1               5                   10                  15      


Arg Val Ser Pro Ser Ile His Gly Tyr His Phe Asp Thr Ala Ser Arg 
            20                  25                  30          


Lys Lys Ala Val Gly Asn Ile Phe Glu Asn Thr Asp Gln Glu Ser Leu 
        35                  40                  45              


Glu Arg Leu Phe Arg Asn Ser Gly Asp Lys Lys Ala Glu Glu Arg Ala 
    50                  55                  60                  


Lys Ile Ile Phe Ala Ile Asp Gln Asp Val Glu Glu Lys Thr Arg Ala 
65                  70                  75                  80  


Leu Met Ala Leu Lys Lys Arg Thr Lys Asp Lys Leu Phe Gln Phe Leu 
                85                  90                  95      


Lys Leu Arg Lys Tyr Ser Ile Lys Val His 
            100                 105     


<210>  163
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Val 
                85                  90                  95      


Glu Asp Gly Glu His Gln Val Lys Met Lys Ala Phe Arg Glu Ala His 
            100                 105                 110         


Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu Ile Glu 
        115                 120                 125             


Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg Lys Leu 
    130                 135                 140                 


Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg Ser Leu 
145                 150                 155                 160 


Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro Ser Phe 
                165                 170                 175     


Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala Glu Gly 
            180                 185                 190         


Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe Val Ser 
        195                 200                 205             


Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu Thr Gly 
    210                 215                 220                 


Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys Val Lys 
225                 230                 235                 240 


Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu Ile Asp 
                245                 250                 255     


Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly Arg Thr 
            260                 265                 270         


Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile Lys Ser 
        275                 280                 285             


Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn Ser Lys 
    290                 295                 300                 


Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly Tyr Leu 
305                 310                 315                 320 


Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg Asn Ser 
                325                 330                 335     


Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly Arg Leu 
            340                 345                 350         


Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val Lys Pro 
        355                 360                 365             


Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val Tyr Val 
    370                 375                 380                 


Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu Leu Leu 
385                 390                 395                 400 


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn Asn Leu 
                405                 410                 415     


Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile Leu Thr 
            420                 425                 430         


Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr Leu Lys 
        435                 440                 445             


Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu Glu Tyr 
    450                 455                 460                 


Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro Gly Glu 
465                 470                 475                 480 


Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser Ser Arg 
                485                 490                 495     


Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val Leu Gly 
            500                 505                 510         


Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp Leu Gln 
        515                 520                 525             


Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr Gly Leu 
    530                 535                 540                 


Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn Lys Glu 
545                 550                 555                 560 


Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala Thr Arg 
                565                 570                 575     


Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu Leu Ser 
            580                 585                 590         


Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp Asp Thr 
        595                 600                 605             


Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly Leu Gly 
    610                 615                 620                 


Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
625                 630                 635     


<210>  164
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ser Met Asn Asn Ser Lys Gln Leu Val Ser Pro Ala Ala Ala Leu 
1               5                   10                  15      


Leu Ser Asn Thr Thr Cys Gln Thr Glu Asn Arg Leu Ser Val Phe Phe 
            20                  25                  30          


Ser Val Ile Phe Met Thr Val Gly Ile Leu Ser Asn Ser Leu Ala Ile 
        35                  40                  45              


Ala Ile Leu Met Lys Ala Tyr Gln Arg Phe Arg Gln Lys Ser Lys Ala 
    50                  55                  60                  


Ser Phe Leu Leu Leu Ala Ser Gly Leu Val Ile Thr Asp Phe Phe Gly 
65                  70                  75                  80  


His Leu Ile Asn Gly Ala Ile Ala Val Phe Val Tyr Ala Ser Asp Lys 
                85                  90                  95      


Glu Trp Ile Arg Phe Asp Gln Ser Asn Val Leu Cys Ser Ile Phe Gly 
            100                 105                 110         


Ile Cys Met Val Phe Ser Gly Leu Cys Pro Leu Leu Leu Gly Ser Val 
        115                 120                 125             


Met Ala Ile Glu Arg Cys Ile Gly Val Thr Lys Pro Ile Phe His Ser 
    130                 135                 140                 


Thr Lys Ile Thr Ser Lys His Val Lys Met Met Leu Ser Gly Val Cys 
145                 150                 155                 160 


Leu Phe Ala Val Phe Ile Ala Leu Leu Pro Ile Leu Gly His Arg Asp 
                165                 170                 175     


Tyr Lys Ile Gln Ala Ser Arg Thr Trp Cys Phe Tyr Asn Thr Glu Asp 
            180                 185                 190         


Ile Lys Asp Trp Glu Asp Arg Phe Tyr Leu Leu Leu Phe Ser Phe Leu 
        195                 200                 205             


Gly Leu Leu Ala Leu Gly Val Ser Leu Leu Cys Asn Ala Ile Thr Gly 
    210                 215                 220                 


Ile Thr Leu Leu Arg Val Lys Phe Lys Ser Gln Gln His Arg Gln Gly 
225                 230                 235                 240 


Arg Ser His His Leu Glu Met Val Ile Gln Leu Leu Ala Ile Met Cys 
                245                 250                 255     


Val Ser Cys Ile Cys Trp Ser Pro Phe Leu Val Thr Met Ala Asn Ile 
            260                 265                 270         


Gly Ile Asn Gly Asn His Ser Leu Glu Thr Cys Glu Thr Thr Leu Phe 
        275                 280                 285             


Ala Leu Arg Met Ala Thr Trp Asn Gln Ile Leu Asp Pro Trp Val Tyr 
    290                 295                 300                 


Ile Leu Leu Arg Lys Ala Val Leu Lys Asn Leu Tyr Lys Leu Ala Ser 
305                 310                 315                 320 


Gln Cys Cys Gly Val His Val Ile Ser Leu His Ile Trp Glu Leu Ser 
                325                 330                 335     


Ser Ile Lys Asn Ser Leu Lys Val Ala Ala Ile Ser Glu Ser Pro Val 
            340                 345                 350         


Ala Glu Lys Ser Ala Ser Thr 
        355                 


<210>  165
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  166
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly 
1               5                   10                  15      


Pro Gly Leu Gly Gly Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly 
            20                  25                  30          


Leu Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
        35                  40                  45              


Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Ile Pro Val Thr 
    50                  55                  60                  


Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu 
65                  70                  75                  80  


Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe 
                85                  90                  95      


Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val 
            100                 105                 110         


Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser 
    130                 135                 140                 


Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu 
145                 150                 155                 160 


Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
                165                 170                 175     


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            180                 185                 190         


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        195                 200                 205             


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    210                 215                 220                 


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr 
225                 230                 235                 240 


Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp 
                245                 250                 255     


Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His 
            260                 265                 270         


Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro 
        275                 280                 285             


Ala Val Ala Thr Thr 
    290             


<210>  167
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Leu Asp Thr Ile Ala Arg Ala Leu Gln Asp Leu Gly Arg Gln Val 
1               5                   10                  15      


Leu Pro Thr Leu Pro Ser Leu Ser Gln Glu Glu Val Ser Ile Ile Trp 
            20                  25                  30          


Gly Asn Val Ser Glu Phe Val Arg Arg Gln Leu Thr Leu His Lys Gly 
        35                  40                  45              


Val Gln Ile Pro Ala Phe Gly Thr Phe Thr Phe Ile Arg Gln Lys Leu 
    50                  55                  60                  


Glu Val Gly Asn Asn Lys Phe Ile Leu Ile Gln Arg Pro Val Phe Ile 
65                  70                  75                  80  


Met Val Glu Lys Leu Val Gln Ile His Gly Leu Lys Gln Asn Lys Val 
                85                  90                  95      


Tyr Thr Pro Gly Glu Ile Pro Ile Val Pro Leu Asn Phe Val Met Ile 
            100                 105                 110         


Ser Leu Glu Gly Pro Phe Asn Arg Asp Val Val Glu Gly Cys Val Lys 
        115                 120                 125             


Glu Thr Leu Leu Phe Leu Ser Arg Ser Ile Ser Met Lys Gln Asn Val 
    130                 135                 140                 


Glu Phe Thr Phe Lys Gly Ile Gly Val Leu Met Ile Arg Asp Ser Lys 
145                 150                 155                 160 


Val Lys Met Arg Phe Tyr Lys Asp Phe Leu Cys Thr Met Asp Gly Ser 
                165                 170                 175     


Gly Ala Leu Ala Lys Ala Leu Ala Asn Arg Pro Gly Thr Val Asp Ser 
            180                 185                 190         


Val Leu Ser Ser Arg Glu Ala Leu Arg Lys Trp Pro Ser Ser Val Leu 
        195                 200                 205             


Ala Phe Pro Arg Ile Glu Leu Lys Glu Met Glu Asn Lys Leu Pro Met 
    210                 215                 220                 


Glu Thr Leu Val Glu Glu Cys Gly Glu Asn Arg Glu Arg Lys Cys Lys 
225                 230                 235                 240 


Leu Lys Asp Gln Ser Asp Lys Glu Glu Gly Thr Arg Asp Ile Ser Ser 
                245                 250                 255     


Pro Lys Arg Leu Arg Asp Arg Gln Ala Leu Phe Pro Ala Lys Val Thr 
            260                 265                 270         


Asn Val Ser Leu Leu Glu Lys Phe Glu Arg Ser Glu Ser Gly Gly Lys 
        275                 280                 285             


Ile Met Thr Pro Glu Ser Leu Ser Tyr Pro Ser Cys Leu Lys His Asp 
    290                 295                 300                 


Ser Glu Met Lys Pro Gln Thr Ser Pro Ala Cys Gln Asp His Asn Lys 
305                 310                 315                 320 


Ala Gly Gln Glu Met Cys Tyr Val Cys Leu Gln Arg Ala Gln Arg Asn 
                325                 330                 335     


Ser Leu Leu Tyr Tyr Ser Glu Glu Arg Arg Arg Glu Ile Glu Asp Glu 
            340                 345                 350         


Arg Leu Ile Gln Gln Tyr Gln Met Leu Lys Asp Gln Glu Ala Leu Phe 
        355                 360                 365             


Arg His Gln Met Lys Ser Leu Ala Thr Arg Glu Gln Asn Gln Lys Asn 
    370                 375                 380                 


Ala Ala Tyr Asn Leu Gly Val Ala Glu Ala Ile Arg Asn His Lys Asn 
385                 390                 395                 400 


Glu Lys Pro Glu Phe Tyr Lys Ser Phe Leu Phe Asp Lys Arg Pro Leu 
                405                 410                 415     


Ser Pro Ala Leu Asn Ala Leu Lys Gln Glu Glu Tyr Ser Arg Ser Leu 
            420                 425                 430         


Leu Lys Gln Met Asp Asn Arg Gln Glu Asn Glu Ile Lys Gln Arg Gln 
        435                 440                 445             


Tyr Arg Glu Leu Met Asp Arg Leu Glu Gln Val Gln Leu Thr Glu Glu 
    450                 455                 460                 


Leu Ala Ala Gln Arg Ala Lys Phe Leu Lys Asp Lys Met Glu Glu Thr 
465                 470                 475                 480 


Gln Cys Tyr Lys Arg Ala Leu Asp Ala Gln Ile Lys Asn Lys Pro Ser 
                485                 490                 495     


Arg Leu Pro Pro Phe Glu Pro Asp Ser Ser Glu Pro Ile Phe Gly Lys 
            500                 505                 510         


Asn Glu Gly Glu Leu Met Val Glu Lys Gln Lys Arg Glu Gln Asn Tyr 
        515                 520                 525             


Met Lys His Gln Leu Glu Ala Ala Ala Asn His Lys Arg Lys Ala Ile 
    530                 535                 540                 


Leu His Gln Leu Val Asp Gln Arg Arg Asp Leu Gln Met Leu Gln Arg 
545                 550                 555                 560 


Thr Gln Arg Glu His Leu Ala Asp Arg Thr Ala Glu Leu Glu Arg Val 
                565                 570                 575     


Asn Arg Val Asn Gln Cys Leu Gln Glu Asp Trp Glu Arg Ser Ala Ala 
            580                 585                 590         


Met Lys Lys Gln Arg Asp Leu Glu Asp Lys Ala Phe Glu Arg Ala Ser 
        595                 600                 605             


Asp Lys Leu Phe Leu Leu Asp Gln Cys Glu Lys Tyr Arg Arg Cys Lys 
    610                 615                 620                 


Gln Cys Gln Arg Arg Thr Ser Asn Val Gly Glu Ser Asn Leu Trp Pro 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Pro Gly Ser Arg Leu Leu Val 
                645                 650         


<210>  168
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  169
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly Arg Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  170
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  171
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  172
<211>  2752
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ala Ser Glu Val Val Cys Gly Leu Ile Phe Arg Leu Leu Leu Pro 
1               5                   10                  15      


Ile Cys Leu Ala Val Ala Cys Ala Phe Arg Tyr Asn Gly Leu Ser Phe 
            20                  25                  30          


Val Tyr Leu Ile Tyr Leu Leu Leu Ile Pro Leu Phe Ser Glu Pro Thr 
        35                  40                  45              


Lys Thr Thr Met Gln Gly His Thr Gly Arg Leu Leu Lys Ser Leu Cys 
    50                  55                  60                  


Phe Ile Ser Leu Ser Phe Leu Leu Leu His Ile Ile Phe His Ile Thr 
65                  70                  75                  80  


Leu Val Ser Leu Glu Ala Gln His Arg Ile Ala Pro Gly Tyr Asn Cys 
                85                  90                  95      


Ser Thr Trp Glu Lys Thr Phe Arg Gln Ile Gly Phe Glu Ser Leu Lys 
            100                 105                 110         


Gly Ala Asp Ala Gly Asn Gly Ile Arg Val Phe Val Pro Asp Ile Gly 
        115                 120                 125             


Met Phe Ile Ala Ser Leu Thr Ile Trp Leu Leu Cys Arg Asn Ile Val 
    130                 135                 140                 


Gln Lys Pro Val Thr Asp Glu Ala Ala Gln Ser Asn Pro Glu Phe Glu 
145                 150                 155                 160 


Asn Glu Glu Leu Ala Glu Gly Glu Lys Ile Asp Ser Glu Glu Ala Leu 
                165                 170                 175     


Ile Tyr Glu Glu Asp Phe Asn Gly Gly Asp Gly Val Glu Gly Glu Leu 
            180                 185                 190         


Glu Glu Ser Thr Lys Leu Lys Met Phe Arg Arg Leu Ala Ser Val Ala 
        195                 200                 205             


Ser Lys Leu Lys Glu Phe Ile Gly Asn Met Ile Thr Thr Ala Gly Lys 
    210                 215                 220                 


Val Val Val Thr Ile Leu Leu Gly Ser Ser Gly Met Met Leu Pro Ser 
225                 230                 235                 240 


Leu Thr Ser Ser Val Tyr Phe Phe Val Phe Leu Gly Leu Cys Thr Trp 
                245                 250                 255     


Trp Ser Trp Cys Arg Thr Phe Asp Pro Leu Leu Phe Ser Cys Leu Cys 
            260                 265                 270         


Val Leu Leu Ala Ile Phe Thr Ala Gly His Leu Ile Gly Leu Tyr Leu 
        275                 280                 285             


Tyr Gln Phe Gln Phe Phe Gln Glu Ala Val Pro Pro Asn Asp Tyr Tyr 
    290                 295                 300                 


Ala Arg Leu Phe Gly Ile Lys Ser Val Ile Gln Thr Asp Cys Ser Ser 
305                 310                 315                 320 


Thr Trp Lys Ile Ile Val Asn Pro Asp Leu Ser Trp Tyr His His Ala 
                325                 330                 335     


Asn Pro Ile Leu Leu Leu Val Met Tyr Tyr Thr Leu Ala Thr Leu Ile 
            340                 345                 350         


Arg Ile Trp Leu Gln Glu Pro Leu Val Gln Asp Glu Gly Thr Lys Glu 
        355                 360                 365             


Glu Asp Lys Ala Leu Ala Cys Ser Pro Ile Gln Ile Thr Ala Gly Arg 
    370                 375                 380                 


Arg Arg Ser Leu Trp Tyr Ala Thr His Tyr Pro Thr Asp Glu Arg Lys 
385                 390                 395                 400 


Leu Leu Ser Met Thr Gln Asp Asp Tyr Lys Pro Ser Asp Gly Leu Leu 
                405                 410                 415     


Val Thr Val Asn Gly Asn Pro Val Asp Tyr His Thr Ile His Pro Ser 
            420                 425                 430         


Leu Pro Met Glu Asn Gly Pro Gly Lys Ala Asp Leu Tyr Ser Thr Pro 
        435                 440                 445             


Gln Tyr Arg Trp Glu Pro Ser Asp Glu Ser Ser Glu Lys Arg Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Lys Glu Glu Phe Glu Glu Glu Arg Ser Arg Glu Glu 
465                 470                 475                 480 


Lys Arg Ser Ile Lys Val His Ala Met Val Ser Val Phe Gln Phe Ile 
                485                 490                 495     


Met Lys Gln Ser Tyr Ile Cys Ala Leu Ile Ala Met Met Ala Trp Ser 
            500                 505                 510         


Ile Thr Tyr His Ser Trp Leu Thr Phe Val Leu Leu Ile Trp Ser Cys 
        515                 520                 525             


Thr Leu Trp Met Ile Arg Asn Arg Arg Lys Tyr Ala Met Ile Ser Ser 
    530                 535                 540                 


Pro Phe Met Val Val Tyr Gly Asn Leu Leu Leu Ile Leu Gln Tyr Ile 
545                 550                 555                 560 


Trp Ser Phe Glu Leu Pro Glu Ile Lys Lys Val Pro Gly Phe Leu Glu 
                565                 570                 575     


Lys Lys Glu Pro Gly Glu Leu Ala Ser Lys Ile Leu Phe Thr Ile Thr 
            580                 585                 590         


Phe Trp Leu Leu Leu Arg Gln His Leu Thr Glu Gln Lys Ala Leu Gln 
        595                 600                 605             


Glu Lys Glu Ala Leu Leu Ser Glu Val Lys Ile Gly Ser Gln Glu Asn 
    610                 615                 620                 


Glu Glu Lys Asp Glu Glu Leu Gln Asp Ile Gln Val Glu Gly Glu Pro 
625                 630                 635                 640 


Lys Glu Glu Glu Glu Glu Glu Ala Lys Glu Glu Lys Gln Glu Arg Lys 
                645                 650                 655     


Lys Val Glu Gln Glu Glu Ala Glu Glu Glu Asp Glu Gln Asp Ile Met 
            660                 665                 670         


Lys Val Leu Gly Asn Leu Val Val Ala Met Phe Ile Lys Tyr Trp Ile 
        675                 680                 685             


Tyr Val Cys Gly Gly Met Phe Phe Phe Val Ser Phe Glu Gly Lys Ile 
    690                 695                 700                 


Val Met Tyr Lys Ile Ile Tyr Met Val Leu Phe Leu Phe Cys Val Ala 
705                 710                 715                 720 


Leu Tyr Gln Val His Tyr Glu Trp Trp Arg Lys Ile Leu Lys Tyr Phe 
                725                 730                 735     


Trp Met Ser Val Val Ile Tyr Thr Met Leu Val Leu Ile Phe Ile Tyr 
            740                 745                 750         


Thr Tyr Gln Phe Glu Asn Phe Pro Gly Leu Trp Gln Asn Met Thr Gly 
        755                 760                 765             


Leu Lys Lys Glu Lys Leu Glu Asp Leu Gly Leu Lys Gln Phe Thr Val 
    770                 775                 780                 


Ala Glu Leu Phe Thr Arg Ile Phe Ile Pro Thr Ser Phe Leu Leu Val 
785                 790                 795                 800 


Cys Ile Leu His Leu His Tyr Phe His Asp Arg Phe Leu Glu Leu Thr 
                805                 810                 815     


Asp Leu Lys Ser Ile Pro Ser Lys Glu Asp Asn Thr Ile Tyr Arg Leu 
            820                 825                 830         


Ala His Pro Glu Gly Ser Leu Pro Asp Leu Thr Met Met His Leu Thr 
        835                 840                 845             


Ala Ser Leu Glu Lys Pro Glu Val Arg Lys Leu Ala Glu Pro Gly Glu 
    850                 855                 860                 


Glu Lys Leu Glu Gly Tyr Ser Glu Lys Ala Gln Lys Gly Asp Leu Gly 
865                 870                 875                 880 


Lys Asp Ser Glu Glu Ser Glu Glu Asp Gly Glu Glu Glu Glu Glu Ser 
                885                 890                 895     


Glu Glu Glu Glu Glu Thr Ser Asp Leu Arg Asn Lys Trp His Leu Val 
            900                 905                 910         


Ile Asp Arg Leu Thr Val Leu Phe Leu Lys Phe Leu Glu Tyr Phe His 
        915                 920                 925             


Lys Leu Gln Val Phe Met Trp Trp Ile Leu Glu Leu His Ile Ile Lys 
    930                 935                 940                 


Ile Val Ser Ser Tyr Ile Ile Trp Val Ser Val Lys Glu Val Ser Leu 
945                 950                 955                 960 


Phe Asn Tyr Val Phe Leu Ile Ser Trp Ala Phe Ala Leu Pro Tyr Ala 
                965                 970                 975     


Lys Leu Arg Arg Leu Ala Ser Ser Val Cys Thr Val Trp Thr Cys Val 
            980                 985                 990         


Ile Ile Val Cys Lys Met Leu Tyr  Gln Leu Gln Thr Ile  Lys Pro Glu 
        995                 1000                 1005             


Asn Phe  Ser Val Asn Cys Ser  Leu Pro Asn Glu Asn  Gln Thr Asn 
    1010                 1015                 1020             


Ile Pro  Phe Asn Glu Leu Asn  Lys Ser Leu Leu Tyr  Ser Ala Pro 
    1025                 1030                 1035             


Ile Asp  Pro Thr Glu Trp Val  Gly Leu Arg Lys Ser  Ser Pro Leu 
    1040                 1045                 1050             


Leu Val  Tyr Leu Arg Asn Asn  Leu Leu Met Leu Ala  Ile Leu Ala 
    1055                 1060                 1065             


Phe Glu  Val Thr Ile Tyr Arg  His Gln Glu Tyr Tyr  Arg Gly Arg 
    1070                 1075                 1080             


Asn Asn  Leu Thr Ala Pro Val  Ser Arg Thr Ile Phe  His Asp Ile 
    1085                 1090                 1095             


Thr Arg  Leu His Leu Asp Asp  Gly Leu Ile Asn Cys  Ala Lys Tyr 
    1100                 1105                 1110             


Phe Ile  Asn Tyr Phe Phe Tyr  Lys Phe Gly Leu Glu  Thr Cys Phe 
    1115                 1120                 1125             


Leu Met  Ser Val Asn Val Ile  Gly Gln Arg Met Asp  Phe Tyr Ala 
    1130                 1135                 1140             


Met Ile  His Ala Cys Trp Leu  Ile Ala Val Leu Tyr  Arg Arg Arg 
    1145                 1150                 1155             


Arg Lys  Ala Ile Ala Glu Ile  Trp Pro Lys Tyr Cys  Cys Phe Leu 
    1160                 1165                 1170             


Ala Cys  Ile Ile Thr Phe Gln  Tyr Phe Ile Cys Ile  Gly Ile Pro 
    1175                 1180                 1185             


Pro Ala  Pro Cys Arg Asp Tyr  Pro Trp Arg Phe Lys  Gly Ala Ser 
    1190                 1195                 1200             


Phe Asn  Asp Asn Ile Ile Lys  Trp Leu Tyr Phe Pro  Asp Phe Ile 
    1205                 1210                 1215             


Val Arg  Pro Asn Pro Val Phe  Leu Val Tyr Asp Phe  Met Leu Leu 
    1220                 1225                 1230             


Leu Cys  Ala Ser Leu Gln Arg  Gln Ile Phe Glu Asp  Glu Asn Lys 
    1235                 1240                 1245             


Ala Ala  Val Arg Ile Met Ala  Gly Asp Asn Val Glu  Ile Cys Met 
    1250                 1255                 1260             


Asn Leu  Asp Ala Ala Ser Phe  Ser Gln His Asn Pro  Val Pro Asp 
    1265                 1270                 1275             


Phe Ile  His Cys Arg Ser Tyr  Leu Asp Met Ser Lys  Val Ile Ile 
    1280                 1285                 1290             


Phe Ser  Tyr Leu Phe Trp Phe  Val Leu Thr Ile Ile  Phe Ile Thr 
    1295                 1300                 1305             


Gly Thr  Thr Arg Ile Ser Ile  Phe Cys Met Gly Tyr  Leu Val Ala 
    1310                 1315                 1320             


Cys Phe  Tyr Phe Leu Leu Phe  Gly Gly Asp Leu Leu  Leu Lys Pro 
    1325                 1330                 1335             


Ile Lys  Ser Ile Leu Arg Tyr  Trp Asp Trp Leu Ile  Ala Tyr Asn 
    1340                 1345                 1350             


Val Phe  Val Ile Thr Met Lys  Asn Ile Leu Ser Ile  Gly Ala Cys 
    1355                 1360                 1365             


Gly Tyr  Ile Gly Thr Leu Val  His Asn Ser Cys Trp  Leu Ile Gln 
    1370                 1375                 1380             


Ala Phe  Ser Leu Ala Cys Thr  Val Lys Gly Tyr Gln  Met Pro Ala 
    1385                 1390                 1395             


Ala Asn  Ser Pro Cys Thr Leu  Pro Ser Gly Glu Ala  Gly Ile Ile 
    1400                 1405                 1410             


Trp Asp  Ser Ile Cys Phe Ala  Phe Leu Leu Leu Gln  Arg Arg Val 
    1415                 1420                 1425             


Phe Met  Ser Tyr Tyr Phe Leu  His Val Val Ala Asp  Ile Lys Ala 
    1430                 1435                 1440             


Ser Gln  Ile Leu Ala Ser Arg  Gly Ala Glu Leu Phe  Gln Ala Thr 
    1445                 1450                 1455             


Ile Val  Lys Ala Val Lys Ala  Arg Ile Glu Glu Glu  Lys Lys Ser 
    1460                 1465                 1470             


Met Asp  Gln Leu Lys Arg Gln  Met Asp Arg Ile Lys  Ala Arg Gln 
    1475                 1480                 1485             


Gln Lys  Tyr Lys Lys Gly Lys  Glu Arg Met Leu Ser  Leu Thr Gln 
    1490                 1495                 1500             


Glu Pro  Gly Glu Gly Gln Asp  Met Gln Lys Leu Ser  Glu Glu Asp 
    1505                 1510                 1515             


Asp Glu  Arg Glu Ala Asp Lys  Gln Lys Ala Lys Gly  Lys Lys Lys 
    1520                 1525                 1530             


Gln Trp  Trp Arg Pro Trp Val  Asp His Ala Ser Met  Val Arg Ser 
    1535                 1540                 1545             


Gly Asp  Tyr Tyr Leu Phe Glu  Thr Asp Ser Glu Glu  Glu Glu Glu 
    1550                 1555                 1560             


Glu Glu  Leu Lys Lys Glu Asp  Glu Glu Pro Pro Arg  Arg Ser Ala 
    1565                 1570                 1575             


Phe Gln  Phe Val Tyr Gln Ala  Trp Ile Thr Asp Pro  Lys Thr Ala 
    1580                 1585                 1590             


Leu Arg  Gln Arg His Lys Glu  Lys Lys Arg Ser Ala  Arg Glu Glu 
    1595                 1600                 1605             


Arg Lys  Arg Arg Arg Lys Gly  Ser Lys Glu Gly Pro  Val Glu Trp 
    1610                 1615                 1620             


Glu Asp  Arg Glu Asp Glu Pro  Ile Lys Lys Lys Ser  Asp Gly Pro 
    1625                 1630                 1635             


Asp Asn  Ile Ile Lys Arg Ile  Phe Asn Ile Leu Lys  Phe Thr Trp 
    1640                 1645                 1650             


Val Leu  Phe Leu Ala Thr Val  Asp Ser Phe Thr Thr  Trp Leu Asn 
    1655                 1660                 1665             


Ser Ile  Ser Arg Glu His Ile  Asp Ile Ser Thr Val  Leu Arg Ile 
    1670                 1675                 1680             


Glu Arg  Cys Met Leu Thr Arg  Glu Ile Lys Lys Gly  Asn Val Pro 
    1685                 1690                 1695             


Thr Arg  Glu Ser Ile His Met  Tyr Tyr Gln Asn His  Ile Met Asn 
    1700                 1705                 1710             


Leu Ser  Arg Glu Ser Gly Leu  Asp Thr Ile Asp Glu  His Pro Gly 
    1715                 1720                 1725             


Ala Ala  Ser Gly Ala Gln Thr  Ala His Arg Met Asp  Ser Leu Asp 
    1730                 1735                 1740             


Ser His  Asp Ser Ile Ser Ser  Glu Pro Thr Gln Cys  Thr Met Leu 
    1745                 1750                 1755             


Tyr Ser  Arg Gln Gly Thr Thr  Glu Thr Ile Glu Glu  Val Glu Ala 
    1760                 1765                 1770             


Glu Gln  Glu Glu Glu Ala Gly  Ser Thr Ala Pro Glu  Pro Arg Glu 
    1775                 1780                 1785             


Ala Lys  Glu Tyr Glu Ala Thr  Gly Tyr Asp Val Gly  Ala Met Gly 
    1790                 1795                 1800             


Ala Glu  Glu Ala Ser Leu Thr  Pro Glu Glu Glu Leu  Thr Gln Phe 
    1805                 1810                 1815             


Ser Thr  Leu Asp Gly Asp Val  Glu Ala Pro Pro Ser  Tyr Ser Lys 
    1820                 1825                 1830             


Ala Val  Ser Phe Glu His Leu  Ser Phe Gly Ser Gln  Asp Asp Ser 
    1835                 1840                 1845             


Ala Gly  Lys Asn Arg Met Ala  Val Ser Pro Asp Asp  Ser Arg Thr 
    1850                 1855                 1860             


Asp Lys  Leu Gly Ser Ser Ile  Leu Pro Pro Leu Thr  His Glu Leu 
    1865                 1870                 1875             


Thr Ala  Ser Glu Leu Leu Leu  Lys Lys Met Phe His  Asp Asp Glu 
    1880                 1885                 1890             


Leu Glu  Glu Ser Glu Lys Phe  Tyr Val Gly Gln Pro  Arg Phe Leu 
    1895                 1900                 1905             


Leu Leu  Phe Tyr Ala Met Tyr  Asn Thr Leu Val Ala  Arg Ser Glu 
    1910                 1915                 1920             


Met Val  Cys Tyr Phe Val Ile  Ile Leu Asn His Met  Val Ser Ala 
    1925                 1930                 1935             


Ser Met  Ile Thr Leu Leu Leu  Pro Ile Leu Ile Phe  Leu Trp Ala 
    1940                 1945                 1950             


Met Leu  Ser Val Pro Arg Pro  Ser Arg Arg Phe Trp  Met Met Ala 
    1955                 1960                 1965             


Ile Val  Tyr Thr Glu Val Ala  Ile Val Val Lys Tyr  Phe Phe Gln 
    1970                 1975                 1980             


Phe Gly  Phe Phe Pro Trp Asn  Lys Asn Val Glu Val  Asn Lys Asp 
    1985                 1990                 1995             


Lys Pro  Tyr His Pro Pro Asn  Ile Ile Gly Val Glu  Lys Lys Glu 
    2000                 2005                 2010             


Gly Tyr  Val Leu Tyr Asp Leu  Ile Gln Leu Leu Ala  Leu Phe Phe 
    2015                 2020                 2025             


His Arg  Ser Ile Leu Lys Cys  His Gly Leu Trp Asp  Glu Asp Asp 
    2030                 2035                 2040             


Met Thr  Glu Ser Gly Met Ala  Arg Glu Glu Ser Asp  Asp Glu Leu 
    2045                 2050                 2055             


Ser Leu  Gly His Gly Arg Arg  Asp Ser Ser Asp Ser  Leu Lys Ser 
    2060                 2065                 2070             


Ile Asn  Leu Ala Ala Ser Val  Glu Ser Val His Val  Thr Phe Pro 
    2075                 2080                 2085             


Glu Gln  Gln Thr Ala Val Arg  Arg Lys Arg Ser Gly  Ser Ser Ser 
    2090                 2095                 2100             


Glu Pro  Ser Gln Arg Ser Ser  Phe Ser Ser Asn Arg  Ser Gln Arg 
    2105                 2110                 2115             


Gly Ser  Thr Ser Thr Arg Asn  Ser Ser Gln Lys Gly  Ser Ser Val 
    2120                 2125                 2130             


Leu Ser  Ile Lys Gln Lys Gly  Lys Arg Glu Leu Tyr  Met Glu Lys 
    2135                 2140                 2145             


Leu Gln  Glu His Leu Ile Lys  Ala Lys Ala Phe Thr  Ile Lys Lys 
    2150                 2155                 2160             


Thr Leu  Glu Ile Tyr Val Pro  Ile Lys Gln Phe Phe  Tyr Asn Leu 
    2165                 2170                 2175             


Ile His  Pro Glu Tyr Ser Ala  Val Thr Asp Val Tyr  Val Leu Met 
    2180                 2185                 2190             


Phe Leu  Ala Asp Thr Val Asp  Phe Ile Ile Ile Val  Phe Gly Phe 
    2195                 2200                 2205             


Trp Ala  Phe Gly Lys His Ser  Ala Ala Ala Asp Ile  Thr Ser Ser 
    2210                 2215                 2220             


Leu Ser  Glu Asp Gln Val Pro  Gly Pro Phe Leu Val  Met Val Leu 
    2225                 2230                 2235             


Ile Gln  Phe Gly Thr Met Val  Val Asp Arg Ala Leu  Tyr Leu Arg 
    2240                 2245                 2250             


Lys Thr  Val Leu Gly Lys Val  Ile Phe Gln Val Ile  Leu Val Phe 
    2255                 2260                 2265             


Gly Ile  His Phe Trp Met Phe  Phe Ile Leu Pro Gly  Val Thr Glu 
    2270                 2275                 2280             


Arg Lys  Phe Ser Gln Asn Leu  Val Ala Gln Leu Trp  Tyr Phe Val 
    2285                 2290                 2295             


Lys Cys  Val Tyr Phe Gly Leu  Ser Ala Tyr Gln Ile  Arg Cys Gly 
    2300                 2305                 2310             


Tyr Pro  Thr Arg Val Leu Gly  Asn Phe Leu Thr Lys  Ser Tyr Asn 
    2315                 2320                 2325             


Tyr Val  Asn Leu Phe Leu Phe  Gln Gly Phe Arg Leu  Val Pro Phe 
    2330                 2335                 2340             


Leu Thr  Glu Leu Arg Ala Val  Met Asp Trp Val Trp  Thr Asp Thr 
    2345                 2350                 2355             


Thr Leu  Ser Leu Ser Ser Trp  Ile Cys Val Glu Asp  Ile Tyr Ala 
    2360                 2365                 2370             


His Ile  Phe Ile Leu Lys Cys  Trp Arg Glu Ser Glu  Lys Arg Tyr 
    2375                 2380                 2385             


Pro Gln  Pro Arg Gly Gln Lys  Lys Lys Lys Val Val  Lys Tyr Gly 
    2390                 2395                 2400             


Met Gly  Gly Met Ile Ile Val  Leu Leu Ile Cys Ile  Val Trp Phe 
    2405                 2410                 2415             


Pro Leu  Leu Phe Met Ser Leu  Ile Lys Ser Val Ala  Gly Val Ile 
    2420                 2425                 2430             


Asn Gln  Pro Leu Asp Val Ser  Val Thr Ile Thr Leu  Gly Gly Tyr 
    2435                 2440                 2445             


Gln Pro  Ile Phe Thr Met Ser  Ala Gln Gln Ser Gln  Leu Lys Val 
    2450                 2455                 2460             


Met Asp  Gln Gln Ser Phe Asn  Lys Phe Ile Gln Ala  Phe Ser Arg 
    2465                 2470                 2475             


Asp Thr  Gly Ala Met Gln Phe  Leu Glu Asn Tyr Glu  Lys Glu Asp 
    2480                 2485                 2490             


Ile Thr  Val Ala Glu Leu Glu  Gly Asn Ser Asn Ser  Leu Trp Thr 
    2495                 2500                 2505             


Ile Ser  Pro Pro Ser Lys Gln  Lys Met Ile His Glu  Leu Leu Asp 
    2510                 2515                 2520             


Pro Asn  Ser Ser Phe Ser Val  Val Phe Ser Trp Ser  Ile Gln Arg 
    2525                 2530                 2535             


Asn Leu  Ser Leu Gly Ala Lys  Ser Glu Ile Ala Thr  Asp Lys Leu 
    2540                 2545                 2550             


Ser Phe  Pro Leu Lys Asn Ile  Thr Arg Lys Asn Ile  Ala Lys Met 
    2555                 2560                 2565             


Ile Ala  Gly Asn Ser Thr Glu  Ser Ser Lys Thr Pro  Val Thr Ile 
    2570                 2575                 2580             


Glu Lys  Ile Tyr Pro Tyr Tyr  Val Lys Ala Pro Ser  Asp Ser Asn 
    2585                 2590                 2595             


Ser Lys  Pro Ile Lys Gln Leu  Leu Ser Glu Asn Asn  Phe Met Asp 
    2600                 2605                 2610             


Ile Thr  Ile Ile Leu Ser Arg  Asp Asn Thr Thr Lys  Tyr Asn Ser 
    2615                 2620                 2625             


Glu Trp  Trp Val Leu Asn Leu  Thr Gly Asn Arg Ile  Tyr Asn Pro 
    2630                 2635                 2640             


Asn Ser  Gln Ala Leu Glu Leu  Val Val Phe Asn Asp  Lys Val Ser 
    2645                 2650                 2655             


Pro Pro  Ser Leu Gly Phe Leu  Ala Gly Tyr Gly Ile  Met Gly Leu 
    2660                 2665                 2670             


Tyr Ala  Ser Val Val Leu Val  Ile Gly Lys Phe Val  Arg Glu Phe 
    2675                 2680                 2685             


Phe Ser  Gly Ile Ser His Ser  Ile Met Phe Glu Glu  Leu Pro Asn 
    2690                 2695                 2700             


Val Asp  Arg Ile Leu Lys Leu  Cys Thr Asp Ile Phe  Leu Val Arg 
    2705                 2710                 2715             


Glu Thr  Gly Glu Leu Glu Leu  Glu Glu Asp Leu Tyr  Ala Lys Leu 
    2720                 2725                 2730             


Ile Phe  Leu Tyr Arg Ser Pro  Glu Thr Met Ile Lys  Trp Thr Arg 
    2735                 2740                 2745             


Glu Lys  Thr Asn 
    2750         


<210>  173
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Glu Glu Gly His Gly Leu Asp Leu Thr Tyr Ile Thr Glu Arg Ile 
1               5                   10                  15      


Ile Ala Val Ser Phe Pro Ala Gly Cys Ser Glu Glu Ser Tyr Leu His 
            20                  25                  30          


Asn Leu Gln Glu Val Thr Arg Met Leu Lys Ser Lys His Gly Asp Asn 
        35                  40                  45              


Tyr Leu Val Leu Asn Leu Ser Glu Lys Arg Tyr Asp Leu Thr Lys Leu 
    50                  55                  60                  


Asn Pro Lys Ile Met Asp Val Gly Trp Pro Glu Leu His Ala Pro Pro 
65                  70                  75                  80  


Leu Asp Lys Met Cys Thr Ile Cys Lys Ala Gln Glu Ser Trp Leu Asn 
                85                  90                  95      


Ser Asn Leu Gln His Val Val Val Ile His Cys Arg Gly Gly Lys Gly 
            100                 105                 110         


Arg Ile Gly Val Val Ile Ser Ser Tyr Met His Phe Thr Asn Val Ser 
        115                 120                 125             


Ala Ser Ala Asp Gln Ala Leu Asp Arg Phe Ala Met Lys Lys Phe Tyr 
    130                 135                 140                 


Asp Asp Lys Val Ser Ala Leu Met Gln Pro Ser Gln Lys Arg Tyr Val 
145                 150                 155                 160 


Gln Phe Leu Ser Gly Leu Leu Ser Gly Ser Val Lys Met Asn Ala Ser 
                165                 170                 175     


Pro Leu Phe Leu His Phe Val Ile Leu His Gly Thr Pro Asn Phe Asp 
            180                 185                 190         


Thr Gly Gly Val Cys Arg Pro Phe Leu Lys Leu Tyr Gln Ala Met Gln 
        195                 200                 205             


Pro Val Tyr Thr Ser Gly Ile Tyr Asn Val Gly Pro Glu Asn Pro Ser 
    210                 215                 220                 


Arg Ile Cys Ile Val Ile Glu Pro Ala Gln Leu Leu Lys Gly Asp Val 
225                 230                 235                 240 


Met Val Lys Cys Tyr His Lys Lys Tyr Arg Ser Ala Thr Arg Asp Val 
                245                 250                 255     


Ile Phe Arg Leu Gln Phe His Thr Gly Ala Val Gln Gly Tyr Gly Leu 
            260                 265                 270         


Val Phe Gly Lys Glu Asp Leu Asp Asn Ala Ser Lys Asp Asp Arg Phe 
        275                 280                 285             


Pro Asp Tyr Gly Lys Val Glu Leu Val Phe Ser Ala Thr Pro Glu Lys 
    290                 295                 300                 


Ile Gln Gly Ser Glu His Leu Tyr Asn Asp His Gly Val Ile Val Asp 
305                 310                 315                 320 


Tyr Asn Thr Thr Asp Pro Leu Ile Arg Trp Asp Ser Tyr Glu Asn Leu 
                325                 330                 335     


Ser Ala Asp Gly Glu Val Leu His Thr Gln Gly Pro Val Asp Gly Ser 
            340                 345                 350         


Leu Tyr Ala Lys Val Arg Lys Lys Ser Ser Ser Asp Pro Gly Ile Pro 
        355                 360                 365             


Gly Gly Pro Gln Ala Ile Pro Ala Thr Asn Ser Pro Asp His Ser Asp 
    370                 375                 380                 


His Thr Leu Ser Val Ser Ser Asp Ser Gly His Ser Thr Ala Ser Ala 
385                 390                 395                 400 


Arg Thr Asp Lys Thr Glu Glu Arg Leu Ala Pro Gly Thr Arg Arg Gly 
                405                 410                 415     


Leu Ser Ala Gln Glu Lys Ala Glu Leu Asp Gln Leu Leu Ser Gly Phe 
            420                 425                 430         


Gly Leu Glu Asp Pro Gly Ser Ser Leu Lys Glu Met Thr Asp Ala Arg 
        435                 440                 445             


Ser Lys Tyr Ser Gly Thr Arg His Val Val Pro Ala Gln Val His Val 
    450                 455                 460                 


Asn Gly Asp Ala Ala Leu Lys Asp Arg Glu Thr Asp Ile Leu Asp Asp 
465                 470                 475                 480 


Glu Met Pro His His Asp Leu His Ser Val Asp Ser Leu Gly Thr Leu 
                485                 490                 495     


Ser Ser Ser Glu Gly Pro Gln Ser Ala His Leu Gly Pro Phe Thr Cys 
            500                 505                 510         


His Lys Ser Ser Gln Asn Ser Leu Leu Ser Asp Gly Phe Gly Ser Asn 
        515                 520                 525             


Val Gly Glu Asp Pro Gln Gly Thr Leu Val Pro Asp Leu Gly Leu Gly 
    530                 535                 540                 


Met Asp Gly Pro Tyr Glu Arg Glu Arg Thr Phe Gly Ser Arg Glu Pro 
545                 550                 555                 560 


Lys Gln Pro Gln Pro Leu Leu Arg Lys Pro Ser Val Ser Ala Gln Met 
                565                 570                 575     


Gln Ala Tyr Gly Gln Ser Ser Tyr Ser Thr Gln Thr Trp Val Arg Gln 
            580                 585                 590         


Gln Gln Met Val Val Ala His Gln Tyr Ser Phe Ala Pro Asp Gly Glu 
        595                 600                 605             


Ala Arg Leu Val Ser Arg Cys Pro Ala Asp Asn Pro Gly Leu Val Gln 
    610                 615                 620                 


Ala Gln Pro Arg Val Pro Leu Thr Pro Thr Arg Gly Thr Ser Ser Arg 
625                 630                 635                 640 


Val Ala Val Gln Arg Gly Val Gly Ser Gly Pro His Pro Pro Asp Thr 
                645                 650                 655     


Gln Gln Pro Ser Pro Ser Lys Ala Phe Lys Pro Arg Phe Pro Gly Asp 
            660                 665                 670         


Gln Val Val Asn Gly Ala Gly Pro Glu Leu Ser Thr Gly Pro Ser Pro 
        675                 680                 685             


Gly Ser Pro Thr Leu Asp Ile Asp Gln Ser Ile Glu Gln Leu Asn Arg 
    690                 695                 700                 


Leu Ile Leu Glu Leu Asp Pro Thr Phe Glu Pro Ile Pro Thr His Met 
705                 710                 715                 720 


Asn Ala Leu Gly Ser Gln Ala Asn Gly Ser Val Ser Pro Asp Ser Val 
                725                 730                 735     


Gly Gly Gly Leu Arg Ala Ser Ser Arg Leu Pro Asp Thr Gly Glu Gly 
            740                 745                 750         


Pro Ser Arg Ala Thr Gly Arg Gln Gly Ser Ser Ala Glu Gln Pro Leu 
        755                 760                 765             


Gly Gly Arg Leu Arg Lys Leu Ser Leu Gly Gln Tyr Asp Asn Asp Ala 
    770                 775                 780                 


Gly Gly Gln Leu Pro Phe Ser Lys Cys Ala Trp Gly Lys Ala Gly Val 
785                 790                 795                 800 


Asp Tyr Ala Pro Asn Leu Pro Pro Phe Pro Ser Pro Ala Asp Val Lys 
                805                 810                 815     


Glu Thr Met Thr Pro Gly Tyr Pro Gln Asp Leu Asp Ile Ile Asp Gly 
            820                 825                 830         


Arg Ile Leu Ser Ser Lys Glu Ser Met Cys Ser Thr Pro Ala Phe Pro 
        835                 840                 845             


Val Ser Pro Glu Thr Pro Tyr Val Lys Thr Ala Leu Arg His Pro Pro 
    850                 855                 860                 


Phe Ser Pro Pro Glu Pro Pro Leu Ser Ser Pro Ala Ser Gln His Lys 
865                 870                 875                 880 


Gly Gly Arg Glu Pro Arg Ser Cys Pro Glu Thr Leu Thr His Ala Val 
                885                 890                 895     


Gly Met Ser Glu Ser Pro Ile Gly Pro Lys Ser Thr Met Leu Arg Ala 
            900                 905                 910         


Asp Ala Ser Ser Thr Pro Ser Phe Gln Gln Ala Phe Ala Ser Ser Cys 
        915                 920                 925             


Thr Ile Ser Ser Asn Gly Pro Gly Gln Arg Arg Glu Ser Ser Ser Ser 
    930                 935                 940                 


Ala Glu Arg Gln Trp Val Glu Ser Ser Pro Lys Pro Met Val Ser Leu 
945                 950                 955                 960 


Leu Gly Ser Gly Arg Pro Thr Gly Ser Pro Leu Ser Ala Glu Phe Ser 
                965                 970                 975     


Gly Thr Arg Lys Asp Ser Pro Val Leu Ser Cys Phe Pro Pro Ser Glu 
            980                 985                 990         


Leu Gln Ala Pro Phe His Ser His  Glu Leu Ser Leu Ala  Glu Pro Pro 
        995                 1000                 1005             


Asp Ser  Leu Ala Pro Pro Ser  Ser Gln Ala Phe Leu  Gly Phe Gly 
    1010                 1015                 1020             


Thr Ala  Pro Val Gly Ser Gly  Leu Pro Pro Glu Glu  Asp Leu Gly 
    1025                 1030                 1035             


Ala Leu  Leu Ala Asn Ser His  Gly Ala Ser Pro Thr  Pro Ser Ile 
    1040                 1045                 1050             


Pro Leu  Thr Ala Thr Gly Ala  Ala Asp Asn Gly Phe  Leu Ser His 
    1055                 1060                 1065             


Asn Phe  Leu Thr Val Ala Pro  Gly His Ser Ser His  His Ser Pro 
    1070                 1075                 1080             


Gly Leu  Gln Gly Gln Gly Val  Thr Leu Pro Gly Gln  Pro Pro Leu 
    1085                 1090                 1095             


Pro Glu  Lys Lys Arg Ala Ser  Glu Gly Asp Arg Ser  Leu Gly Ser 
    1100                 1105                 1110             


Val Ser  Pro Ser Ser Ser Gly  Phe Ser Ser Pro His  Ser Gly Ser 
    1115                 1120                 1125             


Thr Ile  Ser Ile Pro Phe Pro  Asn Val Leu Pro Asp  Phe Ser Lys 
    1130                 1135                 1140             


Ala Ser  Glu Ala Ala Ser Pro  Leu Pro Asp Ser Pro  Gly Asp Lys 
    1145                 1150                 1155             


Leu Val  Ile Val Lys Phe Val  Gln Asp Thr Ser Lys  Phe Trp Tyr 
    1160                 1165                 1170             


Lys Ala  Asp Ile Ser Arg Glu  Gln Ala Ile Ala Met  Leu Lys Asp 
    1175                 1180                 1185             


Lys Glu  Pro Gly Ser Phe Ile  Val Arg Asp Ser His  Ser Phe Arg 
    1190                 1195                 1200             


Gly Ala  Tyr Gly Leu Ala Met  Lys Val Ala Thr Pro  Pro Pro Ser 
    1205                 1210                 1215             


Val Leu  Gln Leu Asn Lys Lys  Ala Gly Asp Leu Ala  Asn Glu Leu 
    1220                 1225                 1230             


Val Arg  His Phe Leu Ile Glu  Cys Thr Pro Lys Gly  Val Arg Leu 
    1235                 1240                 1245             


Lys Gly  Cys Ser Asn Glu Pro  Tyr Phe Gly Ser Leu  Thr Ala Leu 
    1250                 1255                 1260             


Val Cys  Gln His Ser Ile Thr  Pro Leu Ala Leu Pro  Cys Lys Leu 
    1265                 1270                 1275             


Leu Ile  Pro Glu Arg Asp Pro  Leu Glu Glu Ile Ala  Glu Ser Ser 
    1280                 1285                 1290             


Pro Gln  Thr Ala Ala Asn Ser  Ala Ala Glu Leu Leu  Lys Gln Gly 
    1295                 1300                 1305             


Ala Ala  Cys Asn Val Trp Tyr  Leu Asn Ser Val Glu  Met Glu Ser 
    1310                 1315                 1320             


Leu Thr  Gly His Gln Ala Ile  Gln Lys Ala Leu Ser  Ile Thr Leu 
    1325                 1330                 1335             


Val Gln  Glu Pro Pro Pro Val  Ser Thr Val Val His  Phe Lys Val 
    1340                 1345                 1350             


Ser Ala  Gln Gly Ile Thr Leu  Thr Asp Asn Gln Arg  Lys Leu Phe 
    1355                 1360                 1365             


Phe Arg  Arg His Tyr Pro Val  Asn Ser Val Ile Phe  Cys Ala Leu 
    1370                 1375                 1380             


Asp Pro  Gln Asp Arg Lys Trp  Ile Lys Asp Gly Pro  Ser Ser Lys 
    1385                 1390                 1395             


Val Phe  Gly Phe Val Ala Arg  Lys Gln Gly Ser Ala  Thr Asp Asn 
    1400                 1405                 1410             


Val Cys  His Leu Phe Ala Glu  His Asp Pro Glu Gln  Pro Ala Ser 
    1415                 1420                 1425             


Ala Ile  Val Asn Phe Val Ser  Lys Val Met Ile Gly  Ser Pro Lys 
    1430                 1435                 1440             


Lys Val  
    1445 


<210>  174
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  175
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Arg Gln Ser His Gln Leu Pro Leu Val Gly Leu Leu Leu Phe Ser 
1               5                   10                  15      


Phe Ile Pro Ser Gln Leu Cys Glu Ile Cys Glu Val Ser Glu Glu Asn 
            20                  25                  30          


Tyr Ile Arg Leu Lys Pro Leu Leu Asn Thr Met Ile Gln Ser Asn Tyr 
        35                  40                  45              


Asn Arg Gly Thr Ser Ala Val Asn Val Val Leu Ser Leu Lys Leu Val 
    50                  55                  60                  


Gly Ile Gln Ile Gln Thr Leu Met Gln Lys Met Ile Gln Gln Ile Lys 
65                  70                  75                  80  


Tyr Asn Val Lys Ser Arg Leu Ser Asp Val Ser Ser Gly Glu Leu Ala 
                85                  90                  95      


Leu Ile Ile Leu Ala Leu Gly Val Cys Arg Asn Ala Glu Glu Asn Leu 
            100                 105                 110         


Ile Tyr Asp Tyr His Leu Ile Asp Lys Leu Glu Asn Lys Phe Gln Ala 
        115                 120                 125             


Glu Ile Glu Asn Met Glu Ala His Asn Gly Thr Pro Leu Thr Asn Tyr 
    130                 135                 140                 


Tyr Gln Leu Ser Leu Asp Val Leu Ala Leu Cys Leu Phe Asn Gly Asn 
145                 150                 155                 160 


Tyr Ser Thr Ala Glu Val Val Asn His Phe Thr Pro Glu Asn Lys Asn 
                165                 170                 175     


Tyr Tyr Phe Gly Ser Gln Phe Ser Val Asp Thr Gly Ala Met Ala Val 
            180                 185                 190         


Leu Ala Leu Thr Cys Val Lys Lys Ser Leu Ile Asn Gly Gln Ile Lys 
        195                 200                 205             


Ala Asp Glu Gly Ser Leu Lys Asn Ile Ser Ile Tyr Thr Lys Ser Leu 
    210                 215                 220                 


Val Glu Lys Ile Leu Ser Glu Lys Lys Glu Asn Gly Leu Ile Gly Asn 
225                 230                 235                 240 


Thr Phe Ser Thr Gly Glu Ala Met Gln Ala Leu Phe Val Ser Ser Asp 
                245                 250                 255     


Tyr Tyr Asn Glu Asn Asp Trp Asn Cys Gln Gln Thr Leu Asn Thr Val 
            260                 265                 270         


Leu Thr Glu Ile Ser Gln Gly Ala Phe Ser Asn Pro Asn Ala Ala Ala 
        275                 280                 285             


Gln Val Leu Pro Ala Leu Met Gly Lys Thr Phe Leu Asp Ile Asn Lys 
    290                 295                 300                 


Asp Ser Ser Cys Val Ser Ala Ser Gly Asn Phe Asn Ile Ser Ala Asp 
305                 310                 315                 320 


Glu Pro Ile Thr Val Thr Pro Pro Asp Ser Gln Ser Tyr Ile Ser Val 
                325                 330                 335     


Asn Tyr Ser Val Arg Ile Asn Glu Thr Tyr Phe Thr Asn Val Thr Val 
            340                 345                 350         


Leu Asn Gly Ser Val Phe Leu Ser Val Met Glu Lys Ala Gln Lys Met 
        355                 360                 365             


Asn Asp Thr Ile Phe Gly Phe Thr Met Glu Glu Arg Ser Trp Gly Pro 
    370                 375                 380                 


Tyr Ile Thr Cys Ile Gln Gly Leu Cys Ala Asn Asn Asn Asp Arg Thr 
385                 390                 395                 400 


Tyr Trp Glu Leu Leu Ser Gly Gly Glu Pro Leu Ser Gln Gly Ala Gly 
                405                 410                 415     


Ser Tyr Val Val Arg Asn Gly Glu Asn Leu Glu Val Arg Trp Ser Lys 
            420                 425                 430         


Tyr 
    


<210>  176
<211>  1013
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Gly Leu Gly Thr Leu Ser Pro Arg Met Leu Val Trp Leu Val Ala 
1               5                   10                  15      


Ser Gly Ile Val Phe Tyr Gly Glu Leu Trp Val Cys Ala Gly Leu Asp 
            20                  25                  30          


Tyr Asp Tyr Thr Phe Asp Gly Asn Glu Glu Asp Lys Thr Glu Thr Ile 
        35                  40                  45              


Asp Tyr Lys Asp Pro Cys Lys Ala Ala Val Phe Trp Gly Asp Ile Ala 
    50                  55                  60                  


Leu Asp Asp Glu Asp Leu Asn Ile Phe Gln Ile Asp Arg Thr Ile Asp 
65                  70                  75                  80  


Leu Thr Gln Asn Pro Phe Gly Asn Leu Gly His Thr Thr Gly Gly Leu 
                85                  90                  95      


Gly Asp His Ala Met Ser Lys Lys Arg Gly Ala Leu Tyr Gln Leu Ile 
            100                 105                 110         


Asp Arg Ile Arg Arg Ile Gly Phe Gly Leu Glu Gln Asn Asn Thr Val 
        115                 120                 125             


Lys Gly Lys Val Pro Leu Gln Phe Ser Gly Gln Asn Glu Lys Asn Arg 
    130                 135                 140                 


Val Pro Arg Ala Ala Thr Ser Arg Thr Glu Arg Ile Trp Pro Gly Gly 
145                 150                 155                 160 


Val Ile Pro Tyr Val Ile Gly Gly Asn Phe Thr Gly Ser Gln Arg Ala 
                165                 170                 175     


Met Phe Lys Gln Ala Met Arg His Trp Glu Lys His Thr Cys Val Thr 
            180                 185                 190         


Phe Ile Glu Arg Ser Asp Glu Glu Ser Tyr Ile Val Phe Thr Tyr Arg 
        195                 200                 205             


Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg Gly Asn Gly Pro Gln 
    210                 215                 220                 


Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe Gly Ile Val Val His 
225                 230                 235                 240 


Glu Leu Gly His Val Ile Gly Phe Trp His Glu His Thr Arg Pro Asp 
                245                 250                 255     


Arg Asp Asn His Val Thr Ile Ile Arg Glu Asn Ile Gln Pro Gly Gln 
            260                 265                 270         


Glu Tyr Asn Phe Leu Lys Met Glu Pro Gly Glu Val Asn Ser Leu Gly 
        275                 280                 285             


Glu Arg Tyr Asp Phe Asp Ser Ile Met His Tyr Ala Arg Asn Thr Phe 
    290                 295                 300                 


Ser Arg Gly Met Phe Leu Asp Thr Ile Leu Pro Ser Arg Asp Asp Asn 
305                 310                 315                 320 


Gly Ile Arg Pro Ala Ile Gly Gln Arg Thr Arg Leu Ser Lys Gly Asp 
                325                 330                 335     


Ile Ala Gln Ala Arg Lys Leu Tyr Arg Cys Pro Ala Cys Gly Glu Thr 
            340                 345                 350         


Leu Gln Glu Ser Asn Gly Asn Leu Ser Ser Pro Gly Phe Pro Asn Gly 
        355                 360                 365             


Tyr Pro Ser Tyr Thr His Cys Ile Trp Arg Val Ser Val Thr Pro Gly 
    370                 375                 380                 


Glu Lys Ile Val Leu Asn Phe Thr Thr Met Asp Leu Tyr Lys Ser Ser 
385                 390                 395                 400 


Leu Cys Trp Tyr Asp Tyr Ile Glu Val Arg Asp Gly Tyr Trp Arg Lys 
                405                 410                 415     


Ser Pro Leu Leu Gly Arg Phe Cys Gly Asp Lys Leu Pro Glu Val Leu 
            420                 425                 430         


Thr Ser Thr Asp Ser Arg Met Trp Ile Glu Phe Arg Ser Ser Ser Asn 
        435                 440                 445             


Trp Val Gly Lys Gly Phe Ala Ala Val Tyr Glu Ala Ile Cys Gly Gly 
    450                 455                 460                 


Glu Ile Arg Lys Asn Glu Gly Gln Ile Gln Ser Pro Asn Tyr Pro Asp 
465                 470                 475                 480 


Asp Tyr Arg Pro Met Lys Glu Cys Val Trp Lys Ile Thr Val Ser Glu 
                485                 490                 495     


Ser Tyr His Val Gly Leu Thr Phe Gln Ser Phe Glu Ile Glu Arg His 
            500                 505                 510         


Asp Asn Cys Ala Tyr Asp Tyr Leu Glu Val Arg Asp Gly Thr Ser Glu 
        515                 520                 525             


Asn Ser Pro Leu Ile Gly Arg Phe Cys Gly Tyr Asp Lys Pro Glu Asp 
    530                 535                 540                 


Ile Arg Ser Thr Ser Asn Thr Leu Trp Met Lys Phe Val Ser Asp Gly 
545                 550                 555                 560 


Thr Val Asn Lys Ala Gly Phe Ala Ala Asn Phe Phe Lys Glu Glu Asp 
                565                 570                 575     


Glu Cys Ala Lys Pro Asp Arg Gly Gly Cys Glu Gln Arg Cys Leu Asn 
            580                 585                 590         


Thr Leu Gly Ser Tyr Gln Cys Ala Cys Glu Pro Gly Tyr Glu Leu Gly 
        595                 600                 605             


Pro Asp Arg Arg Ser Cys Glu Ala Ala Cys Gly Gly Leu Leu Thr Lys 
    610                 615                 620                 


Leu Asn Gly Thr Ile Thr Thr Pro Gly Trp Pro Lys Glu Tyr Pro Pro 
625                 630                 635                 640 


Asn Lys Asn Cys Val Trp Gln Val Val Ala Pro Thr Gln Tyr Arg Ile 
                645                 650                 655     


Ser Val Lys Phe Glu Phe Phe Glu Leu Glu Gly Asn Glu Val Cys Lys 
            660                 665                 670         


Tyr Asp Tyr Val Glu Ile Trp Ser Gly Leu Ser Ser Glu Ser Lys Leu 
        675                 680                 685             


His Gly Lys Phe Cys Gly Ala Glu Val Pro Glu Val Ile Thr Ser Gln 
    690                 695                 700                 


Phe Asn Asn Met Arg Ile Glu Phe Lys Ser Asp Asn Thr Val Ser Lys 
705                 710                 715                 720 


Lys Gly Phe Lys Ala His Phe Phe Ser Asp Lys Asp Glu Cys Ser Lys 
                725                 730                 735     


Asp Asn Gly Gly Cys Gln His Glu Cys Val Asn Thr Met Gly Ser Tyr 
            740                 745                 750         


Met Cys Gln Cys Arg Asn Gly Phe Val Leu His Asp Asn Lys His Asp 
        755                 760                 765             


Cys Lys Glu Ala Glu Cys Glu Gln Lys Ile His Ser Pro Ser Gly Leu 
    770                 775                 780                 


Ile Thr Ser Pro Asn Trp Pro Asp Lys Tyr Pro Ser Arg Lys Glu Cys 
785                 790                 795                 800 


Thr Trp Glu Ile Ser Ala Thr Pro Gly His Arg Ile Lys Leu Ala Phe 
                805                 810                 815     


Ser Glu Phe Glu Ile Glu Gln His Gln Glu Cys Ala Tyr Asp His Leu 
            820                 825                 830         


Glu Val Phe Asp Gly Glu Thr Glu Lys Ser Pro Ile Leu Gly Arg Leu 
        835                 840                 845             


Cys Gly Asn Lys Ile Pro Asp Pro Leu Val Ala Thr Gly Asn Lys Met 
    850                 855                 860                 


Phe Val Arg Phe Val Ser Asp Ala Ser Val Gln Arg Lys Gly Phe Gln 
865                 870                 875                 880 


Ala Thr His Ser Thr Glu Cys Gly Gly Arg Leu Lys Ala Glu Ser Lys 
                885                 890                 895     


Pro Arg Asp Leu Tyr Ser His Ala Gln Phe Gly Asp Asn Asn Tyr Pro 
            900                 905                 910         


Gly Gln Val Asp Cys Glu Trp Leu Leu Val Ser Glu Arg Gly Ser Arg 
        915                 920                 925             


Leu Glu Leu Ser Phe Gln Thr Phe Glu Val Glu Glu Glu Ala Asp Cys 
    930                 935                 940                 


Gly Tyr Asp Tyr Val Glu Leu Phe Asp Gly Leu Asp Ser Thr Ala Val 
945                 950                 955                 960 


Gly Leu Gly Arg Phe Cys Gly Ser Gly Pro Pro Glu Glu Ile Tyr Ser 
                965                 970                 975     


Ile Gly Asp Ser Val Leu Ile His Phe His Thr Asp Asp Thr Ile Asn 
            980                 985                 990         


Lys Lys Gly Phe His Ile Arg Tyr  Lys Ser Ile Arg Tyr  Pro Asp Thr 
        995                 1000                 1005             


Thr His  Thr Lys Lys 
    1010             


<210>  177
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  178
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Lys Asp Asn Ser Thr Val Arg Cys Phe Gln Gly Leu Leu Ile 
1               5                   10                  15      


Phe Gly Asn Val Ile Ile Gly Cys Cys Gly Ile Ala Leu Thr Ala Glu 
            20                  25                  30          


Cys Ile Phe Phe Val Ser Asp Gln His Ser Leu Tyr Pro Leu Leu Glu 
        35                  40                  45              


Ala Thr Asp Asn Asp Asp Ile Tyr Gly Ala Ala Trp Ile Gly Ile Phe 
    50                  55                  60                  


Val Gly Ile Cys Leu Phe Cys Leu Ser Val Leu Gly Ile Val Gly Ile 
65                  70                  75                  80  


Met Lys Ser Ser Arg Lys Ile Leu Leu Ala Tyr Phe Ile Leu Met Phe 
                85                  90                  95      


Ile Val Tyr Ala Phe Glu Val Ala Ser Cys Ile Thr Ala Ala Thr Gln 
            100                 105                 110         


Gln Asp Phe Phe Thr Pro Asn Leu Phe Leu Lys Gln Met Leu Glu Arg 
        115                 120                 125             


Tyr Gln Asn Asn Ser Pro Pro Asn Asn Asp Asp Gln Trp Lys Asn Asn 
    130                 135                 140                 


Gly Val Thr Lys Thr Trp Asp Arg Leu Met Leu Gln Asp Asn Cys Cys 
145                 150                 155                 160 


Gly Val Asn Gly Pro Ser Asp Trp Gln Lys Tyr Thr Ser Ala Phe Arg 
                165                 170                 175     


Thr Glu Asn Asn Asp Ala Asp Tyr Pro Trp Pro Arg Gln Cys Cys Val 
            180                 185                 190         


Met Asn Asn Leu Lys Glu Pro Leu Asn Leu Glu Ala Cys Lys Leu Gly 
        195                 200                 205             


Val Pro Gly Phe Tyr His Asn Gln Gly Cys Tyr Glu Leu Ile Ser Gly 
    210                 215                 220                 


Pro Met Asn Arg His Ala Trp Gly Val Ala Trp Phe Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Cys Trp Thr Phe Trp Val Leu Leu Gly Thr Met Phe Tyr Trp Ser 
                245                 250                 255     


Arg Ile Glu Tyr 
            260 


<210>  179
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  180
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Val Leu Leu His Trp Cys Leu Leu Trp Leu Leu Phe Pro Leu Ser 
1               5                   10                  15      


Ser Arg Thr Gln Lys Leu Pro Thr Arg Asp Glu Glu Leu Phe Gln Met 
            20                  25                  30          


Gln Ile Arg Asp Lys Ala Phe Phe His Asp Ser Ser Val Ile Pro Asp 
        35                  40                  45              


Gly Ala Glu Ile Ser Ser Tyr Leu Phe Arg Asp Thr Pro Lys Arg Tyr 
    50                  55                  60                  


Phe Phe Val Val Glu Glu Asp Asn Thr Pro Leu Ser Val Thr Val Thr 
65                  70                  75                  80  


Pro Cys Asp Ala Pro Leu Glu Trp Lys Leu Ser Leu Gln Glu Leu Pro 
                85                  90                  95      


Glu Asp Arg Ser Gly Glu Gly Ser Gly Asp Leu Glu Pro Leu Glu Gln 
            100                 105                 110         


Gln Lys Gln Gln Ile Ile Asn Glu Glu Gly Thr Glu Leu Phe Ser Tyr 
        115                 120                 125             


Lys Gly Asn Asp Val Glu Tyr Phe Ile Ser Ser Ser Ser Pro Ser Gly 
    130                 135                 140                 


Leu Tyr Gln Leu Asp Leu Leu Ser Thr Glu Lys Asp Thr His Phe Lys 
145                 150                 155                 160 


Val Tyr Ala Thr Thr Thr Pro Glu Ser Asp Gln Pro Tyr Pro Glu Leu 
                165                 170                 175     


Pro Tyr Asp Pro Arg Val Asp Val Thr Ser Leu Gly Arg Thr Thr Val 
            180                 185                 190         


Thr Leu Ala Trp Lys Pro Ser Pro Thr Ala Ser Leu Leu Lys Gln Pro 
        195                 200                 205             


Ile Gln Tyr Cys Val Val Ile Asn Lys Glu His Asn Phe Lys Ser Leu 
    210                 215                 220                 


Cys Ala Val Glu Ala Lys Leu Ser Ala Asp Asp Ala Phe Met Met Ala 
225                 230                 235                 240 


Pro Lys Pro Gly Leu Asp Phe Ser Pro Phe Asp Phe Ala His Phe Gly 
                245                 250                 255     


Phe Pro Ser Asp Asn Ser Gly Lys Glu Arg Ser Phe Gln Ala Lys Pro 
            260                 265                 270         


Ser Pro Lys Leu Gly Arg His Val Tyr Ser Arg Pro Lys Val Asp Ile 
        275                 280                 285             


Gln Lys Ile Cys Ile Gly Asn Lys Asn Ile Phe Thr Val Ser Asp Leu 
    290                 295                 300                 


Lys Pro Asp Thr Gln Tyr Tyr Phe Asp Val Phe Val Val Asn Ile Asn 
305                 310                 315                 320 


Ser Asn Met Ser Thr Ala Tyr Val Gly Thr Phe Ala Arg Thr Lys Glu 
                325                 330                 335     


Glu Ala Lys Gln Lys Thr Val Glu Leu Lys Asp Gly Lys Ile Thr Asp 
            340                 345                 350         


Val Phe Val Lys Arg Lys Gly Ala Lys Phe Leu Arg Phe Ala Pro Val 
        355                 360                 365             


Ser Ser His Gln Lys Val Thr Phe Phe Ile His Ser Cys Leu Asp Ala 
    370                 375                 380                 


Val Gln Ile Gln Val Arg Arg Asp Gly Lys Leu Leu Leu Ser Gln Asn 
385                 390                 395                 400 


Val Glu Gly Ile Gln Gln Phe Gln Leu Arg Gly Lys Pro Lys Ala Lys 
                405                 410                 415     


Tyr Leu Val Arg Leu Lys Gly Asn Lys Lys Gly Ala Ser Met Leu Lys 
            420                 425                 430         


Ile Leu Ala Thr Thr Arg Pro Thr Lys Gln Ser Phe Pro Ser Leu Pro 
        435                 440                 445             


Glu Asp Thr Arg Ile Lys Ala Phe Asp Lys Leu Arg Thr Cys Ser Ser 
    450                 455                 460                 


Ala Thr Val Ala Trp Leu Gly Thr Gln Glu Arg Asn Lys Phe Cys Ile 
465                 470                 475                 480 


Tyr Lys Lys Glu Val Asp Asp Asn Tyr Asn Glu Asp Gln Lys Lys Arg 
                485                 490                 495     


Glu Gln Asn Gln Cys Leu Gly Pro Asp Ile Arg Lys Lys Ser Glu Lys 
            500                 505                 510         


Val Leu Cys Lys Tyr Phe His Ser Gln Asn Leu Gln Lys Ala Val Thr 
        515                 520                 525             


Thr Glu Thr Ile Lys Gly Leu Gln Pro Gly Lys Ser Tyr Leu Leu Asp 
    530                 535                 540                 


Val Tyr Val Ile Gly His Gly Gly His Ser Val Lys Tyr Gln Ser Lys 
545                 550                 555                 560 


Val Val Lys Thr Arg Lys Phe Cys 
                565             


<210>  181
<211>  1116
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Glu Ser Pro Leu Ile Tyr Val Ser Val Leu Leu Leu Asn Ile Phe 
1               5                   10                  15      


Glu Phe Ser Ser Gly Ile Val Tyr Asn Lys Asp Asp Thr Glu Lys Arg 
            20                  25                  30          


Phe Ala Cys Ser Asn Lys Gly Phe Pro Gln Glu Asn Glu Ile Ile Lys 
        35                  40                  45              


Leu Tyr Leu Phe Leu Glu Asn Leu Lys Ile Gln Cys Phe Phe Gln Thr 
    50                  55                  60                  


Glu Asn Glu Ile Ala Ser Lys Ala Met Leu Ser Val Phe Thr Ser Gly 
65                  70                  75                  80  


Gly Leu Ala Pro Ser Leu Gly Ile Met Asn Ser Thr Tyr Asn Gly Ile 
                85                  90                  95      


Phe His Phe Asn Leu Thr Leu Phe Ser Asp Arg Ile Leu Trp Leu Val 
            100                 105                 110         


Asp Ile Pro Arg Glu Asn Ile Thr Gln Ser Thr Asp Ile Ala Ala Val 
        115                 120                 125             


Glu Glu Trp Leu Val Arg Ile Thr Leu His His Gly Leu Asn Ile Tyr 
    130                 135                 140                 


Ala Thr Glu Gly Thr Leu Leu Asp Val Ile Arg Glu Pro Ile Leu Gln 
145                 150                 155                 160 


Trp Thr Pro Gly Asp Val Ile Pro Glu Ser Glu Ile Ser Lys Leu Tyr 
                165                 170                 175     


Pro His Val Val Asp Leu Lys Val Thr Lys Cys Pro Cys Ala Asn Asp 
            180                 185                 190         


Val Ala Leu Leu Gly Phe Ile Val Asp Thr Ile Val Asp Gly Val Tyr 
        195                 200                 205             


Ile Gly Ile Thr Phe Gly Gly Phe Trp His Asp Tyr Asp Thr Thr Trp 
    210                 215                 220                 


Phe Asn Met Thr Gln Thr Ile Tyr Ser Gln Leu Gln Glu Glu Tyr Glu 
225                 230                 235                 240 


Asp Leu Ser Leu Val Asp Met Val Leu Thr Asn His Phe Leu Val Ile 
                245                 250                 255     


Leu Thr Ser Leu Gly Leu Phe Val Ser Glu Asp Leu Arg Tyr Pro Ser 
            260                 265                 270         


Arg His Ser Leu Ser Phe Ser Arg Ala Asp Phe Cys Gly Phe Glu Arg 
        275                 280                 285             


Val Asp Tyr Val Lys Gly Lys Leu Trp Tyr Asn Glu Arg Cys Phe Ala 
    290                 295                 300                 


Asn Arg Glu His Phe Glu Val Asp Tyr Val Thr Val Thr Phe Glu Arg 
305                 310                 315                 320 


Asn Arg Thr Leu Ser Glu Ser Ser Ser Cys Phe Tyr Ser Gln Glu Pro 
                325                 330                 335     


Phe Leu Glu Trp Val Pro Cys Leu Pro His Ile Phe Lys Gly Ile Lys 
            340                 345                 350         


Ile Phe Pro Thr Val Leu Thr Phe Leu Val Asp Gln Glu Arg Gly Thr 
        355                 360                 365             


Gly Val Tyr Leu Phe Tyr Asn Lys Val Arg Lys Thr Ala Ile Ala Ser 
    370                 375                 380                 


Val Ser Thr Leu Arg Asn Asn Glu Pro Asn Ser Gln Ser Lys Phe Pro 
385                 390                 395                 400 


Ile Phe Arg Phe Pro Ser Ser Phe Ser Ser Pro Val Gly Met Val Phe 
                405                 410                 415     


His Pro Arg Ser His Phe Leu Tyr Ala Tyr Gly Asn Gln Ile Trp Leu 
            420                 425                 430         


Ser Val Asp Gly Gly Asn Thr Phe Gln Leu Ile Ala Asn Phe His Asp 
        435                 440                 445             


Asp Ile Ile Lys Lys Thr Phe His Ser Phe Tyr Thr Ser Ala Ile Thr 
    450                 455                 460                 


Phe Val Ser Gln Arg Gly Lys Val Tyr Ser Thr Lys Ala Gly Met Gly 
465                 470                 475                 480 


Arg Tyr Ser Ala Val Gly Ser Val Thr Glu Arg Ile Phe Thr Leu Tyr 
                485                 490                 495     


Tyr Asp His Leu Gly Phe Leu His Lys Leu Thr Leu Gly Arg Phe Glu 
            500                 505                 510         


Ala Ser Gly Pro Pro Thr Ala Phe Gly Asn Ser Arg Asn Leu Phe Gly 
        515                 520                 525             


Gln Pro Pro Asp Met Gly Phe Glu Thr Ala Leu Ala Pro Gln His Thr 
    530                 535                 540                 


Ser Leu Asp Glu Ile Ile Phe Phe Ala Tyr Val Pro Glu Asn Glu Pro 
545                 550                 555                 560 


Gln Glu Thr Ile Tyr Ser Lys Lys Phe Gly Asn Ile His Tyr Gly Lys 
                565                 570                 575     


Val Ile His Ser Gly Lys Thr Gly Arg Ala Tyr Ile Arg Lys Val Leu 
            580                 585                 590         


Gln His Thr Thr Pro Lys Gly Phe Leu Ser Ser Val Ile Ala Glu Met 
        595                 600                 605             


Lys Glu Pro Phe Gly Leu Glu Glu Val Asn Glu Ser Ser Cys Leu Ser 
    610                 615                 620                 


Ser Ser Leu Leu Ile Asn Lys Ala Gly Asn Val Tyr Lys Leu Thr Leu 
625                 630                 635                 640 


Asp Ser Gln Val Val Gln Ala Leu Phe Glu Asp Thr Asp Ile Glu Lys 
                645                 650                 655     


Thr Val Val Leu Pro Gly Tyr Ser Ser Phe Leu Ile Thr Ser Ile Leu 
            660                 665                 670         


Asp Asn Lys Asn Ala Leu Ala Ile Ala Thr Met Pro Glu Ser Ala Pro 
        675                 680                 685             


Asn Asn Met Thr Phe Leu Lys Ser Thr Trp Phe Leu Tyr Asn Phe Gly 
    690                 695                 700                 


Gln Arg Asn Gly Arg Thr Trp Lys Ile Tyr Ser Lys Pro Cys Asn Tyr 
705                 710                 715                 720 


Trp Phe Gln His Asp Asp Ser Pro Ser Leu Asn Ile Val Lys Tyr Ile 
                725                 730                 735     


Asp Leu Gly Asn Ser Tyr Val Leu Lys Ala Lys Val Ile Arg Asn Ala 
            740                 745                 750         


Lys Gly Phe Arg Met Leu Glu Ile Pro Leu Leu Thr Val Phe Val Gly 
        755                 760                 765             


Asn Pro Asn Leu Leu Glu Val Thr Ala Glu Val Thr Phe Asp Asp Thr 
    770                 775                 780                 


Asp Ser Tyr Val Ile Thr Ile Ser Ala Ala Ser Lys Val Leu His Gln 
785                 790                 795                 800 


Gly Ser Thr Ser Leu Ala Phe Ile Met Trp Ser Ala Ser Thr Glu Cys 
                805                 810                 815     


Phe Val Thr Thr Met Val Pro Thr Leu Lys Ser Ser Cys Ser Tyr Leu 
            820                 825                 830         


Arg Ser Met His His Ile Pro Ser Lys Phe Ile Pro Phe Glu Asp Trp 
        835                 840                 845             


Ile Ser Gly Val His Lys Asp Ser Gln Gly Phe Asn Leu Ile Lys Thr 
    850                 855                 860                 


Leu Pro Ile Asn Tyr Arg Pro Pro Ser Asn Met Gly Ile Ala Ile Pro 
865                 870                 875                 880 


Leu Thr Asp Asn Phe Tyr His Ala Asp Pro Ser Lys Pro Ile Pro Arg 
                885                 890                 895     


Asn Met Phe His Met Ser Lys Lys Thr Gly Lys Phe Lys Gln Cys Ala 
            900                 905                 910         


Asn Val Ser Thr Arg Glu Glu Cys Asn Cys Thr Lys Asp Gln Lys Phe 
        915                 920                 925             


Ser His Ala Val Ala Phe Ser Asp Cys Arg Glu Lys Val Pro Arg Phe 
    930                 935                 940                 


Lys Phe Pro Ile Thr Gln Tyr Pro Val Ser Leu Glu Ile Ile Asn Glu 
945                 950                 955                 960 


Asp Gly Arg Val Pro Leu Gln Ser Pro Tyr Leu Val Thr Val Thr Glu 
                965                 970                 975     


Val Asn Met Arg His Asn Trp Lys Leu Lys His Thr Val Pro Glu Asn 
            980                 985                 990         


Ile Lys Arg Met Lys Gln Leu Val  Glu Pro Ile Leu Gly  Ala Ala Val 
        995                 1000                 1005             


Tyr Asn  Pro Ser Gly Leu Asn  Leu Ser Ile Lys Gly  Ser Glu Leu 
    1010                 1015                 1020             


Phe His  Phe Arg Val Thr Val  Ile Ser Gly Val Thr  Phe Cys Asn 
    1025                 1030                 1035             


Leu Ile  Glu Glu Phe Gln Ile  Tyr Val Asp Glu Ala  Pro Leu Pro 
    1040                 1045                 1050             


Phe Pro  Gly His Thr Leu Ile  Ala Val Ala Thr Ala  Val Val Leu 
    1055                 1060                 1065             


Gly Gly  Leu Ile Phe Ile Ala  Phe Met Phe Gln Leu  Gln Gly Ile 
    1070                 1075                 1080             


His Pro  Trp Arg Thr Phe Gln  Arg Trp Ile Arg Arg  Asn Gln Glu 
    1085                 1090                 1095             


Lys Phe  Ser Ser Ile Ser Leu  Ser Glu Leu Ile His  Arg Ser Lys 
    1100                 1105                 1110             


Ser Glu  Glu 
    1115     


<210>  182
<211>  1439
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Thr Leu Ala Cys Arg Val Gln Phe Leu Asp Asp Thr Asp Pro 
1               5                   10                  15      


Phe Asn Ser Thr Asn Phe Pro Glu Pro Ser Arg Pro Pro Leu Phe Thr 
            20                  25                  30          


Phe Arg Glu Asp Leu Ala Leu Gly Thr Gln Leu Ala Gly Val His Arg 
        35                  40                  45              


Leu Leu Gln Ala Pro His Lys Leu Asp Asp Cys Thr Leu Gln Leu Ser 
    50                  55                  60                  


His Asn Gly Ala Tyr Leu Asp Leu Glu Ala Thr Leu Ala Glu Gln Arg 
65                  70                  75                  80  


Asp Glu Leu Glu Gly Phe Gln Asp Asp Ala Gly Arg Gly Lys Lys His 
                85                  90                  95      


Ser Ile Ile Leu Arg Thr Gln Leu Ser Val Arg Val His Ala Cys Ile 
            100                 105                 110         


Glu Lys Leu Tyr Asn Ser Ser Gly Arg Asp Leu Arg Arg Ala Leu Phe 
        115                 120                 125             


Ser Leu Lys Gln Ile Phe Gln Asp Asp Lys Asp Leu Val His Glu Phe 
    130                 135                 140                 


Val Val Ala Glu Gly Leu Thr Cys Leu Ile Lys Val Gly Ala Glu Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Gln Asn Tyr Ile Leu Arg Ala Leu Gly Gln Ile Met 
                165                 170                 175     


Leu Tyr Val Asp Gly Met Asn Gly Val Ile Asn Arg Asn Glu Thr Ile 
            180                 185                 190         


Gln Trp Leu Tyr Thr Leu Ile Gly Ser Lys Phe Arg Leu Val Val Lys 
        195                 200                 205             


Thr Ala Leu Lys Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Ser Asn 
    210                 215                 220                 


Ala Pro Leu Leu Ile Gln Ala Val Thr Ala Val Asp Thr Lys Arg Gly 
225                 230                 235                 240 


Val Lys Pro Trp Ser Asn Ile Met Glu Ile Leu Glu Glu Lys Asp Gly 
                245                 250                 255     


Val Asp Thr Glu Leu Leu Val Tyr Ala Met Thr Leu Val Asn Lys Thr 
            260                 265                 270         


Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe Tyr Asp Val Val Asp Cys 
        275                 280                 285             


Leu Glu Glu Leu Gly Ile Ala Ala Val Ser Gln Arg His Leu Asn Lys 
    290                 295                 300                 


Lys Gly Thr Asp Leu Asp Leu Val Glu Gln Leu Asn Ile Tyr Glu Val 
305                 310                 315                 320 


Ala Leu Arg His Glu Asp Gly Asp Glu Thr Thr Glu Pro Pro Pro Ser 
                325                 330                 335     


Gly Cys Arg Asp Arg Arg Arg Ala Ser Val Cys Ser Ser Gly Gly Gly 
            340                 345                 350         


Glu His Arg Gly Leu Asp Arg Arg Arg Ser Arg Arg His Ser Val Gln 
        355                 360                 365             


Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr Ser Pro Cys Ser Gln Ser 
    370                 375                 380                 


Ala Pro Ser Phe Lys Pro Asn Gln Val Arg Asp Leu Arg Glu Lys Tyr 
385                 390                 395                 400 


Ser Asn Phe Gly Asn Asn Ser Tyr His Ser Ser Arg Pro Ser Ser Gly 
                405                 410                 415     


Ser Ser Val Pro Thr Thr Pro Thr Ser Ser Val Ser Pro Pro Gln Glu 
            420                 425                 430         


Ala Arg Leu Glu Arg Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe 
        435                 440                 445             


Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln 
    450                 455                 460                 


Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys 
465                 470                 475                 480 


Phe Ser Arg Asp Tyr Leu Asp Lys Arg Glu Glu Gln Arg Gln Ala Arg 
                485                 490                 495     


Glu Glu Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu 
            500                 505                 510         


Lys Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser 
        515                 520                 525             


Leu Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser 
    530                 535                 540                 


His Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala 
545                 550                 555                 560 


Ser Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp Pro 
                565                 570                 575     


Glu Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln 
            580                 585                 590         


Val Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala 
        595                 600                 605             


Glu Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala 
    610                 615                 620                 


Ser Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp 
625                 630                 635                 640 


Asn Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg 
                645                 650                 655     


Glu Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp 
            660                 665                 670         


Pro Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile 
        675                 680                 685             


Leu Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg 
    690                 695                 700                 


Lys Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr 
705                 710                 715                 720 


Gln Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr 
                725                 730                 735     


Leu Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp 
            740                 745                 750         


Val Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys 
        755                 760                 765             


Phe Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu 
    770                 775                 780                 


Pro Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu 
785                 790                 795                 800 


Ser Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg 
                805                 810                 815     


Ile Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile Asp 
            820                 825                 830         


Val Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro Pro 
        835                 840                 845             


Pro Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro Pro 
    850                 855                 860                 


Leu Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu Val 
865                 870                 875                 880 


Pro Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser Gln 
                885                 890                 895     


Val Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg 
            900                 905                 910         


Leu Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn 
        915                 920                 925             


Arg Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val 
    930                 935                 940                 


Asp Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu 
945                 950                 955                 960 


Ser Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile 
                965                 970                 975     


Val Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val 
            980                 985                 990         


Leu Pro Pro Pro Arg Thr Ile Lys  Ile Ala Ile Leu Asn  Phe Asp Glu 
        995                 1000                 1005             


Tyr Ala  Leu Asn Lys Glu Gly  Ile Glu Lys Ile Leu  Thr Met Ile 
    1010                 1015                 1020             


Pro Thr  Asp Glu Glu Lys Gln  Lys Ile Gln Glu Ala  Gln Leu Ala 
    1025                 1030                 1035             


Asn Pro  Glu Ile Pro Leu Gly  Ser Ala Glu Gln Phe  Leu Leu Thr 
    1040                 1045                 1050             


Leu Ser  Ser Ile Ser Glu Leu  Ser Ala Arg Leu His  Leu Trp Ala 
    1055                 1060                 1065             


Phe Lys  Met Asp Tyr Glu Thr  Thr Glu Lys Glu Val  Ala Glu Pro 
    1070                 1075                 1080             


Leu Leu  Asp Leu Lys Glu Gly  Ile Asp Gln Leu Glu  Asn Asn Lys 
    1085                 1090                 1095             


Thr Leu  Gly Phe Ile Leu Ser  Thr Leu Leu Ala Ile  Gly Asn Phe 
    1100                 1105                 1110             


Leu Asn  Gly Thr Asn Ala Lys  Ala Phe Glu Leu Ser  Tyr Leu Glu 
    1115                 1120                 1125             


Lys Val  Pro Glu Val Lys Asp  Thr Val His Lys Gln  Ser Leu Leu 
    1130                 1135                 1140             


His His  Val Cys Thr Met Val  Val Glu Asn Phe Pro  Asp Ser Ser 
    1145                 1150                 1155             


Asp Leu  Tyr Ser Glu Ile Gly  Ala Ile Thr Arg Ser  Ala Lys Val 
    1160                 1165                 1170             


Asp Phe  Asp Gln Leu Gln Asp  Asn Leu Cys Gln Met  Glu Arg Arg 
    1175                 1180                 1185             


Cys Lys  Ala Ser Trp Asp His  Leu Lys Ala Ile Ala  Lys His Glu 
    1190                 1195                 1200             


Met Lys  Pro Val Leu Lys Gln  Arg Met Ser Glu Phe  Leu Lys Asp 
    1205                 1210                 1215             


Cys Ala  Glu Arg Ile Ile Ile  Leu Lys Ile Val His  Arg Arg Ile 
    1220                 1225                 1230             


Ile Asn  Arg Phe His Ser Phe  Leu Leu Phe Met Gly  His Pro Pro 
    1235                 1240                 1245             


Tyr Ala  Ile Arg Glu Val Asn  Ile Asn Lys Phe Cys  Arg Ile Ile 
    1250                 1255                 1260             


Ser Glu  Phe Ala Leu Glu Tyr  Arg Thr Thr Arg Glu  Arg Val Leu 
    1265                 1270                 1275             


Gln Gln  Lys Gln Lys Arg Ala  Asn His Arg Glu Arg  Asn Lys Thr 
    1280                 1285                 1290             


Arg Gly  Lys Met Ile Thr Asp  Ser Gly Lys Phe Ser  Gly Ser Ser 
    1295                 1300                 1305             


Pro Ala  Pro Pro Ser Gln Pro  Gln Gly Leu Ser Tyr  Ala Glu Asp 
    1310                 1315                 1320             


Ala Ala  Glu His Glu Asn Met  Lys Ala Val Leu Lys  Thr Ser Ser 
    1325                 1330                 1335             


Pro Ser  Val Glu Asp Ala Thr  Pro Ala Leu Gly Val  Arg Thr Arg 
    1340                 1345                 1350             


Ser Arg  Ala Ser Arg Gly Ser  Thr Ser Ser Trp Thr  Met Gly Thr 
    1355                 1360                 1365             


Asp Asp  Ser Pro Asn Val Thr  Asp Asp Ala Ala Asp  Glu Ile Met 
    1370                 1375                 1380             


Asp Arg  Ile Val Lys Ser Ala  Thr Gln Val Pro Ser  Gln Arg Val 
    1385                 1390                 1395             


Val Pro  Arg Glu Arg Lys Arg  Ser Arg Ala Asn Arg  Lys Ser Leu 
    1400                 1405                 1410             


Arg Arg  Thr Leu Lys Ser Gly  Leu Thr Pro Glu Glu  Ala Arg Ala 
    1415                 1420                 1425             


Leu Gly  Leu Val Gly Thr Ser  Glu Leu Gln Leu 
    1430                 1435                 


<210>  183
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ala Arg Ser Leu Val Cys Leu Gly Val Ile Ile Leu Leu Ser Ala 
1               5                   10                  15      


Phe Ser Gly Pro Gly Val Arg Gly Gly Pro Met Pro Lys Leu Ala Asp 
            20                  25                  30          


Arg Lys Leu Cys Ala Asp Gln Glu Cys Ser His Pro Ile Ser Met Ala 
        35                  40                  45              


Val Ala Leu Gln Asp Tyr Met Ala Pro Asp Cys Arg Phe Leu Thr Ile 
    50                  55                  60                  


His Arg Gly Gln Val Val Tyr Val Phe Ser Lys Leu Lys Gly Arg Gly 
65                  70                  75                  80  


Arg Leu Phe Trp Gly Gly Ser Val Gln Gly Asp Tyr Tyr Gly Asp Leu 
                85                  90                  95      


Ala Ala Arg Leu Gly Tyr Phe Pro Ser Ser Ile Val Arg Glu Asp Gln 
            100                 105                 110         


Thr Leu Lys Pro Gly Lys Val Asp Val Lys Thr Asp Lys Trp Asp Phe 
        115                 120                 125             


Tyr Cys Gln 
    130     


<210>  184
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  185
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Ser Cys Ser Phe Thr Arg Asp Gln Ala Thr Arg Arg Leu Arg 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Ala Ala Ala Leu Ala Ala Val Val Thr Thr 
            20                  25                  30          


Pro Leu Leu Ser Ser Gly Thr Pro Thr Ala Leu Ile Gly Thr Gly Ser 
        35                  40                  45              


Ser Cys Pro Gly Ala Met Trp Leu Ser Thr Ala Thr Gly Ser Arg Ser 
    50                  55                  60                  


Asp Ser Glu Ser Glu Glu Glu Asp Leu Pro Val Gly Glu Glu Val Cys 
65                  70                  75                  80  


Lys Arg Gly Tyr Leu Arg Lys Gln Lys His Gly His Arg Arg Tyr Phe 
                85                  90                  95      


Val Leu Lys Leu Glu Thr Ala Asp Ala Pro Ala Arg Leu Glu Tyr Tyr 
            100                 105                 110         


Glu Asn Ala Arg Lys Phe Arg His Ser Val Arg Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ser Gly Ala Ala Ile Pro Pro Leu Ile Pro Pro 
    130                 135                 140                 


Arg Arg Val Ile Thr Leu Tyr Gln Cys Phe Ser Val Ser Gln Arg Ala 
145                 150                 155                 160 


Asp Ala Arg Tyr Arg His Leu Ile Ala Leu Phe Thr Gln Asp Glu Tyr 
                165                 170                 175     


Phe Ala Met Val Ala Glu Asn Glu Ser Glu Gln Glu Ser Trp Tyr Leu 
            180                 185                 190         


Leu Leu Ser Arg Leu Ile Leu Glu Ser Lys Arg Arg Arg Cys Gly Thr 
        195                 200                 205             


Leu Gly Ala Gln Pro Asp Gly Glu Pro Ala Ala Leu Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Glu Pro Pro Phe Tyr Lys Asp Val Trp Gln Val Ile Val Lys 
225                 230                 235                 240 


Pro Arg Gly Leu Gly His Arg Lys Glu Leu Ser Gly Val Phe Arg Leu 
                245                 250                 255     


Cys Leu Thr Asp Glu Glu Val Val Phe Val Arg Leu Asn Thr Glu Val 
            260                 265                 270         


Ala Ser Val Val Val Gln Leu Leu Ser Ile Arg Arg Cys Gly His Ser 
        275                 280                 285             


Glu Gln Tyr Phe Phe Leu Glu Val Gly Arg Ser Thr Val Ile Gly Pro 
    290                 295                 300                 


Gly Glu Leu Trp Met Gln Val Asp Asp Cys Val Val Ala Gln Asn Met 
305                 310                 315                 320 


His Glu Leu Phe Leu Glu Lys Met Arg Ala Leu Cys Ala Asp Glu Tyr 
                325                 330                 335     


Arg Ala Arg Cys Arg Ser Tyr Ser Ile Ser Ile Gly Ala His Leu Leu 
            340                 345                 350         


Thr Leu Leu Ser Ala Arg Arg His Leu Gly Leu Val Pro Leu Glu Pro 
        355                 360                 365             


Gly Gly Trp Leu Arg Arg Ser Arg Phe Glu Gln Phe Cys His Leu Arg 
    370                 375                 380                 


Ala Ile Gly Asp Gly Glu Asp Glu Met Leu Phe Thr Arg Arg Phe Val 
385                 390                 395                 400 


Thr Pro Ser Glu Pro Val Ala His Ser Arg Arg Gly Arg Leu His Leu 
                405                 410                 415     


Pro Arg Gly Arg Arg Ser Arg Arg Ala Val Ser Val Pro Ala Ser Phe 
            420                 425                 430         


Phe Arg Arg Leu Ala Pro Ser Pro Ala Arg Pro Arg His Pro Ala Glu 
        435                 440                 445             


Ala Pro Asn Asn Gly Ala Arg Leu Ser Ser Glu Val Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Asn Phe Gly Glu Glu Gly Asn Pro Gln Gly Lys Glu Asp Gln 
465                 470                 475                 480 


Glu Gly Ser Gly Gly Asp Tyr Met Pro Met Asn Asn Trp Gly Ser Gly 
                485                 490                 495     


Asn Gly Arg Gly Ser Gly Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser 
            500                 505                 510         


Ser Ser His Ser Ser Gly Gly Asn Gln Cys Ser Gly Glu Gly Gln Gly 
        515                 520                 525             


Ser Arg Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser Gly Gly Asn Gln 
    530                 535                 540                 


Cys Ser Arg Asp Gly Gln Gly Thr Ala Gly Gly His Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Arg Pro Gly Gly Gly His Gly Ser Gly Gly Gly Gln Gly Pro 
                565                 570                 575     


Gly Asp Gly His Gly Ser Gly Gly Gly Lys Asn Ser Gly Gly Gly Lys 
            580                 585                 590         


Gly Ser Gly Ser Gly Lys Gly Ser Asp Gly Asp Gly Glu Arg Gly Lys 
        595                 600                 605             


Ser Leu Lys Lys Arg Ser Tyr Phe Gly Lys Leu Thr Gln Ser Lys Gln 
    610                 615                 620                 


Gln Gln Met Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala 
625                 630                 635                 640 


Gly Gly Thr Gly Gly Lys Gly Lys Ser Gly Gly Arg Phe Arg Leu Tyr 
                645                 650                 655     


Phe Cys Val Asp Arg Gly Ala Thr Lys Glu Cys Lys Glu Ala Lys Glu 
            660                 665                 670         


Val Lys Asp Ala Glu Ile Pro Glu Gly Ala Ala Arg Gly Pro His Arg 
        675                 680                 685             


Ala Arg Ala Phe Asp Glu Asp Glu Asp Asp Pro Tyr Val Pro Met Arg 
    690                 695                 700                 


Pro Gly Val Ala Thr Pro Leu Val Ser Ser Ser Asp Tyr Met Pro Met 
705                 710                 715                 720 


Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg His Ser Arg Ser Pro 
                725                 730                 735     


Phe Glu Asp Ser Arg Gly Tyr Met Met Met Phe Pro Arg Val Ser Pro 
            740                 745                 750         


Pro Pro Ala Pro Ser Pro Pro Lys Ala Pro Asp Thr Asn Lys Glu Asp 
        755                 760                 765             


Asp Ser Lys Asp Asn Asp Ser Glu Ser Asp Tyr Met Phe Met Ala Pro 
    770                 775                 780                 


Gly Ala Gly Ala Ile Pro Lys Asn Pro Arg Asn Pro Gln Gly Gly Ser 
785                 790                 795                 800 


Ser Ser Lys Ser Trp Ser Ser Tyr Phe Ser Leu Pro Asn Pro Phe Arg 
                805                 810                 815     


Ser Ser Pro Leu Gly Gln Asn Asp Asn Ser Glu Tyr Val Pro Met Leu 
            820                 825                 830         


Pro Gly Lys Phe Leu Gly Arg Gly Leu Asp Lys Glu Val Ser Tyr Asn 
        835                 840                 845             


Trp Asp Pro Lys Asp Ala Ala Ser Lys Pro Ser Gly Glu Gly Ser Phe 
    850                 855                 860                 


Ser Lys Pro Gly Asp Gly Gly Ser Pro Ser Lys Pro Ser Asp His Glu 
865                 870                 875                 880 


Pro Pro Lys Asn Lys Ala Lys Arg Pro Asn Arg Leu Ser Phe Ile Thr 
                885                 890                 895     


Lys Gly Tyr Lys Ile Lys Pro Lys Pro Gln Lys Pro Thr His Glu Gln 
            900                 905                 910         


Arg Glu Ala Asp Ser Ser Ser Asp Tyr Val Asn Met Asp Phe Thr Lys 
        915                 920                 925             


Arg Glu Ser Asn Thr Pro Ala Pro Ser Thr Gln Gly Leu Pro Asp Ser 
    930                 935                 940                 


Trp Gly Ile Ile Ala Glu Pro Arg Gln Ser Ala Phe Ser Asn Tyr Val 
945                 950                 955                 960 


Asn Val Glu Phe Gly Val Pro Phe Pro Asn Pro Ala Asn Asp Leu Ser 
                965                 970                 975     


Asp Leu Leu Arg Ala Ile Pro Arg Ala Asn Pro Leu Ser Leu Asp Ser 
            980                 985                 990         


Ala Arg Trp Pro Leu Pro Pro Leu  Pro Leu Ser Ala Thr  Gly Ser Asn 
        995                 1000                 1005             


Ala Ile  Glu Glu Glu Gly Asp  Tyr Ile Glu Val Ile  Phe Asn Ser 
    1010                 1015                 1020             


Ala Met  Thr Pro Ala Met Ala  Leu Ala Asp Ser Ala  Ile Arg Tyr 
    1025                 1030                 1035             


Asp Ala  Glu Thr Gly Arg Ile  Tyr Val Val Asp Pro  Phe Ser Glu 
    1040                 1045                 1050             


Cys Cys  Met Asp Ile Ser Leu  Ser Pro Ser Arg Cys  Ser Glu Pro 
    1055                 1060                 1065             


Pro Pro  Val Ala Arg Leu Leu  Gln Glu Glu Glu Gln  Glu Arg Arg 
    1070                 1075                 1080             


Arg Pro  Gln Ser Arg Ser Gln  Ser Phe Phe Ala Ala  Ala Arg Ala 
    1085                 1090                 1095             


Ala Val  Ser Ala Phe Pro Thr  Asp Ser Leu Glu Arg  Asp Leu Ser 
    1100                 1105                 1110             


Pro Ser  Ser Ala Pro Ala Val  Ala Ser Ala Ala Glu  Pro Thr Leu 
    1115                 1120                 1125             


Ala Leu  Ser Gln Val Val Ala  Ala Ala Ser Ala Leu  Ala Ala Ala 
    1130                 1135                 1140             


Pro Gly  Ile Gly Ala Ala Ala  Ala Ala Ala Gly Phe  Asp Ser Ala 
    1145                 1150                 1155             


Ser Ala  Arg Trp Phe Gln Pro  Val Ala Asn Ala Ala  Asp Ala Glu 
    1160                 1165                 1170             


Ala Val  Arg Gly Ala Gln Asp  Val Ala Gly Gly Ser  Asn Pro Gly 
    1175                 1180                 1185             


Ala His  Asn Pro Ser Ala Asn  Leu Ala Arg Gly Asp  Asn Gln Ala 
    1190                 1195                 1200             


Gly Gly  Ala Ala Ala Ala Ala  Ala Ala Pro Glu Pro  Pro Pro Arg 
    1205                 1210                 1215             


Ser Arg  Arg Val Pro Arg Pro  Pro Glu Arg Glu Asp  Ser Asp Asn 
    1220                 1225                 1230             


Asp Asp  Asp Thr His Val Arg  Met Asp Phe Ala Arg  Arg Asp Asn 
    1235                 1240                 1245             


Gln Phe  Asp Ser Pro Lys Arg  Gly Arg 
    1250                 1255         


<210>  186
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Pro Leu Gln Gly Ser Val Ser Phe Lys Asp Val Thr Val Asp Phe 
1               5                   10                  15      


Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ala Gln Lys Ala Leu Tyr 
            20                  25                  30          


Arg Asp Val Met Leu Glu Asn Tyr Cys His Phe Val Ser Val Gly Phe 
        35                  40                  45              


His Met Ala Lys Pro Asp Met Ile Arg Lys Leu Glu Gln Gly Glu Glu 
    50                  55                  60                  


Leu Trp Thr Gln Arg Ile Phe Pro Ser Tyr Ser Tyr Leu Glu Glu Asp 
65                  70                  75                  80  


Gly Lys Thr Glu Asp Val Leu Val Lys Phe Lys Glu Tyr Gln Asp Arg 
                85                  90                  95      


His Ser Arg Pro Leu Ile Phe Ile Asn His Lys Lys Leu Ile Lys Glu 
            100                 105                 110         


Arg Ser Asn Ile Tyr Gly Lys Thr Phe Thr Leu Gly Lys Asn Arg Ile 
        115                 120                 125             


Ser Lys Thr Ile Leu Cys Glu Tyr Lys Pro Asp Gly Lys Val Leu Lys 
    130                 135                 140                 


Asn Ile Ser Glu Leu Val Ile Arg Asn Ile Ser Pro Ile Lys Glu Lys 
145                 150                 155                 160 


Phe Gly Asp Ser Thr Gly Trp Glu Lys Ser Leu Leu Asn Thr Lys His 
                165                 170                 175     


Glu Lys Ile His Pro Ala Val Asn Leu His Lys Gln Thr Glu Arg Val 
            180                 185                 190         


Leu Ser Gly Lys Gln Glu Leu Ile Gln His Gln Lys Val Gln Ala Pro 
        195                 200                 205             


Glu Gln Pro Phe Asp His Asn Glu Cys Glu Lys Ser Phe Leu Met Lys 
    210                 215                 220                 


Gly Met Leu Phe Thr His Thr Arg Ala His Arg Gly Glu Arg Thr Phe 
225                 230                 235                 240 


Glu Tyr Asn Lys Asp Gly Ile Ala Phe Ile Glu Lys Ser Ser Leu Ser 
                245                 250                 255     


Val His Pro Ser Asn Leu Met Glu Lys Lys Pro Ser Ala Tyr Asn Lys 
            260                 265                 270         


Tyr Gly Lys Phe Leu Cys Arg Lys Pro Val Phe Ile Met Pro Gln Arg 
        275                 280                 285             


Pro Gln Thr Glu Glu Lys Pro Phe His Cys Pro Tyr Cys Gly Asn Asn 
    290                 295                 300                 


Phe Arg Arg Lys Ser Tyr Leu Ile Glu His Gln Arg Ile His Thr Gly 
305                 310                 315                 320 


Glu Lys Pro Tyr Val Cys Asn Gln Cys Gly Lys Ala Phe Arg Gln Lys 
                325                 330                 335     


Thr Ala Leu Thr Leu His Glu Lys Thr His Ile Glu Gly Lys Pro Phe 
            340                 345                 350         


Ile Cys Ile Asp Cys Gly Lys Ser Phe Arg Gln Lys Ala Thr Leu Thr 
        355                 360                 365             


Arg His His Lys Thr His Thr Gly Glu Lys Ala Tyr Glu Cys Pro Gln 
    370                 375                 380                 


Cys Gly Ser Ala Phe Arg Lys Lys Ser Tyr Leu Ile Asp His Gln Arg 
385                 390                 395                 400 


Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Glu Cys Gly Lys Ala 
                405                 410                 415     


Phe Ile Gln Lys Thr Thr Leu Thr Val His Gln Arg Thr His Thr Gly 
            420                 425                 430         


Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Cys Gln Lys 
        435                 440                 445             


Thr Thr Leu Thr Leu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460                 


Ile Cys Asn Glu Cys Gly Lys Ser Phe Arg Gln Lys Ala Ile Leu Thr 
465                 470                 475                 480 


Val His His Arg Ile His Thr Gly Glu Lys Ser Asn Gly Cys Pro Gln 
                485                 490                 495     


Cys Gly Lys Ala Phe Ser Arg Lys Ser Asn Leu Ile Arg His Gln Lys 
            500                 505                 510         


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Phe 
        515                 520                 525             


Phe Ser Cys Lys Ser Asn Leu Ile Val His Gln Lys Thr His Lys Val 
    530                 535                 540                 


Glu Thr Thr Gly Ile Gln 
545                 550 


<210>  187
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ala Cys Asn Ile Pro Asn Gln Arg Gln Arg Thr Leu Ser Thr Thr 
1               5                   10                  15      


Gly Glu Ala Leu Tyr Glu Ile Leu Gly Leu His Lys Gly Ala Ser Asn 
            20                  25                  30          


Glu Glu Ile Lys Lys Thr Tyr Arg Lys Leu Ala Leu Lys His His Pro 
        35                  40                  45              


Asp Lys Asn Pro Asp Asp Pro Ala Ala Thr Glu Lys Phe Lys Glu Ile 
    50                  55                  60                  


Asn Asn Ala His Ala Ile Leu Thr Asp Ile Ser Lys Arg Ser Ile Tyr 
65                  70                  75                  80  


Asp Lys Tyr Gly Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Asp 
                85                  90                  95      


Glu Asn Val Asn Thr Tyr Phe Met Leu Ser Ser Trp Trp Ala Lys Ala 
            100                 105                 110         


Leu Phe Val Ile Val Gly Leu Leu Thr Gly Cys Tyr Phe Cys Cys Cys 
        115                 120                 125             


Leu Cys Cys Cys Cys Asn Cys Cys Cys Gly His Cys Arg Pro Glu Ser 
    130                 135                 140                 


Ser Val Pro Glu Glu Asp Phe Tyr Val Ser Pro Glu Asp Leu Glu Glu 
145                 150                 155                 160 


Gln Ile Lys Ser Asp Met Glu Lys Asp Val Asp Phe Pro Val Phe Leu 
                165                 170                 175     


Gln Pro Thr Asn Ala Asn Glu Lys Thr Gln Leu Ile Lys Glu Gly Ser 
            180                 185                 190         


Arg Ser Tyr Cys Thr Asp Ser 
        195                 


<210>  188
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Ser Leu Ala Ala Ala Asn Ala Glu Phe Cys Phe Asn Leu Phe 
1               5                   10                  15      


Arg Glu Met Asp Asp Asn Gln Gly Asn Gly Asn Val Phe Phe Ser Ser 
            20                  25                  30          


Leu Ser Leu Phe Ala Ala Leu Ala Leu Val Arg Leu Gly Ala Gln Asp 
        35                  40                  45              


Asp Ser Leu Ser Gln Ile Asp Lys Leu Leu His Val Asn Thr Ala Ser 
    50                  55                  60                  


Gly Tyr Gly Asn Ser Ser Asn Ser Gln Ser Gly Leu Gln Ser Gln Leu 
65                  70                  75                  80  


Lys Arg Val Phe Ser Asp Ile Asn Ala Ser His Lys Asp Tyr Asp Leu 
                85                  90                  95      


Ser Ile Val Asn Gly Leu Phe Ala Glu Lys Val Tyr Gly Phe His Lys 
            100                 105                 110         


Asp Tyr Ile Glu Cys Ala Glu Lys Leu Tyr Asp Ala Lys Val Glu Arg 
        115                 120                 125             


Val Asp Phe Thr Asn His Leu Glu Asp Thr Arg Arg Asn Ile Asn Lys 
    130                 135                 140                 


Trp Val Glu Asn Glu Thr His Gly Lys Ile Lys Asn Val Ile Gly Glu 
145                 150                 155                 160 


Gly Gly Ile Ser Ser Ser Ala Val Met Val Leu Val Asn Ala Val Tyr 
                165                 170                 175     


Phe Lys Gly Lys Trp Gln Ser Ala Phe Thr Lys Ser Glu Thr Ile Asn 
            180                 185                 190         


Cys His Phe Lys Ser Pro Lys Cys Ser Gly Lys Ala Val Ala Met Met 
        195                 200                 205             


His Gln Glu Arg Lys Phe Asn Leu Ser Val Ile Glu Asp Pro Ser Met 
    210                 215                 220                 


Lys Ile Leu Glu Leu Arg Tyr Asn Gly Gly Ile Asn Met Tyr Val Leu 
225                 230                 235                 240 


Leu Pro Glu Asn Asp Leu Ser Glu Ile Glu Asn Lys Leu Thr Phe Gln 
                245                 250                 255     


Asn Leu Met Glu Trp Thr Asn Pro Arg Arg Met Thr Ser Lys Tyr Val 
            260                 265                 270         


Glu Val Phe Phe Pro Gln Phe Lys Ile Glu Lys Asn Tyr Glu Met Lys 
        275                 280                 285             


Gln Tyr Leu Arg Ala Leu Gly Leu Lys Asp Ile Phe Asp Glu Ser Lys 
    290                 295                 300                 


Ala Asp Leu Ser Gly Ile Ala Ser Gly Gly Arg Leu Tyr Ile Ser Arg 
305                 310                 315                 320 


Met Met His Lys Ser Tyr Ile Glu Val Thr Glu Glu Gly Thr Glu Ala 
                325                 330                 335     


Thr Ala Ala Thr Gly Ser Asn Ile Val Glu Lys Gln Leu Pro Gln Ser 
            340                 345                 350         


Thr Leu Phe Arg Ala Asp His Pro Phe Leu Phe Val Ile Arg Lys Asp 
        355                 360                 365             


Asp Ile Ile Leu Phe Ser Gly Lys Val Ser Cys Pro 
    370                 375                 380 


<210>  189
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Gln Leu Pro Arg Trp Trp Glu Leu Gly Asp Pro Cys Ala Trp Thr 
1               5                   10                  15      


Gly Gln Gly Arg Gly Thr Arg Arg Met Ser Pro Ala Thr Thr Gly Thr 
            20                  25                  30          


Phe Leu Leu Thr Val Tyr Ser Ile Phe Ser Lys Val His Ser Asp Arg 
        35                  40                  45              


Asn Val Tyr Pro Ser Ala Gly Val Leu Phe Val His Val Leu Glu Arg 
    50                  55                  60                  


Glu Tyr Phe Lys Gly Glu Phe Pro Pro Tyr Pro Lys Pro Gly Glu Ile 
65                  70                  75                  80  


Ser Asn Asp Pro Ile Thr Phe Asn Thr Asn Leu Met Gly Tyr Pro Asp 
                85                  90                  95      


Arg Pro Gly Trp Leu Arg Tyr Ile Gln Arg Thr Pro Tyr Ser Asp Gly 
            100                 105                 110         


Val Leu Tyr Gly Ser Pro Thr Ala Glu Asn Val Gly Lys Pro Thr Ile 
        115                 120                 125             


Ile Glu Ile Thr Ala Tyr Asn Arg Arg Thr Phe Glu Thr Ala Arg His 
    130                 135                 140                 


Asn Leu Ile Ile Asn Ile Met Ser Ala Glu Asp Phe Pro Leu Pro Tyr 
145                 150                 155                 160 


Gln Ala Glu Phe Phe Ile Lys Asn Met Asn Val Glu Glu Met Leu Ala 
                165                 170                 175     


Ser Glu Val Leu Gly Asp Phe Leu Gly Ala Val Lys Asn Val Trp Gln 
            180                 185                 190         


Pro Glu Arg Leu Asn Ala Ile Asn Ile Thr Ser Ala Leu Asp Arg Gly 
        195                 200                 205             


Gly Arg Val Pro Leu Pro Ile Asn Asp Leu Lys Glu Gly Val Tyr Val 
    210                 215                 220                 


Met Val Gly Ala Asp Val Pro Phe Ser Ser Cys Leu Arg Glu Val Glu 
225                 230                 235                 240 


Asn Pro Gln Asn Gln Leu Arg Cys Ser Gln Glu Met Glu Pro Val Ile 
                245                 250                 255     


Thr Cys Asp Lys Lys Phe Arg Thr Gln Phe Tyr Ile Asp Trp Cys Lys 
            260                 265                 270         


Ile Ser Leu Val Asp Lys Thr Lys Gln Val Ser Thr Tyr Gln Glu Val 
        275                 280                 285             


Ile Arg Gly Glu Gly Ile Leu Pro Asp Gly Gly Glu Tyr Lys Pro Pro 
    290                 295                 300                 


Ser Asp Ser Leu Lys Ser Arg Asp Tyr Tyr Thr Asp Phe Leu Ile Thr 
305                 310                 315                 320 


Leu Ala Val Pro Ser Ala Val Ala Leu Val Leu Phe Leu Ile Leu Ala 
                325                 330                 335     


Tyr Ile Met Cys Cys Arg Arg Glu Gly Val Glu Lys Arg Asn Met Gln 
            340                 345                 350         


Thr Pro Asp Ile Gln Leu Val His His Ser Ala Ile Gln Lys Ser Thr 
        355                 360                 365             


Lys Glu Leu Arg Asp Met Ser Lys Asn Arg Glu Ile Ala Trp Pro Leu 
    370                 375                 380                 


Ser Thr Leu Pro Val Phe His Pro Val Thr Gly Glu Ile Ile Pro Pro 
385                 390                 395                 400 


Leu His Thr Asp Asn Tyr Asp Ser Thr Asn Met Pro Leu Met Gln Thr 
                405                 410                 415     


Gln Gln Trp Ser Phe Ala Pro Val Ala Gln Ala Gly Val Gln Trp Ser 
            420                 425                 430         


Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Arg Asn Leu Pro His Gln 
        435                 440                 445             


Thr Gln Ile Pro Gln Gln Gln Thr Thr Gly Lys Trp Tyr Pro 
    450                 455                 460         


<210>  190
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Thr His Ala Leu Glu Ile Ala Gly Leu Phe Leu Gly Gly Val 
1               5                   10                  15      


Gly Met Val Gly Thr Val Ala Val Thr Val Met Pro Gln Trp Arg Val 
            20                  25                  30          


Ser Ala Phe Ile Glu Asn Asn Ile Val Val Phe Glu Asn Phe Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Arg Gln Ala Asn Ile Arg Met Gln Cys 
    50                  55                  60                  


Lys Ile Tyr Asp Ser Leu Leu Ala Leu Ser Pro Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Gly Leu Met Cys Ala Ala Ser Val Met Ser Phe Leu Ala Phe Met 
                85                  90                  95      


Met Ala Ile Leu Gly Met Lys Cys Thr Arg Cys Thr Gly Asp Asn Glu 
            100                 105                 110         


Lys Val Lys Ala His Ile Leu Leu Thr Ala Gly Ile Ile Phe Ile Ile 
        115                 120                 125             


Thr Gly Met Val Val Leu Ile Pro Val Ser Trp Val Ala Asn Ala Ile 
    130                 135                 140                 


Ile Arg Asp Phe Tyr Asn Ser Ile Val Asn Val Ala Gln Lys Arg Glu 
145                 150                 155                 160 


Leu Gly Glu Ala Leu Tyr Leu Gly Trp Thr Thr Ala Leu Val Leu Ile 
                165                 170                 175     


Val Gly Gly Ala Leu Phe Cys Cys Val Phe Cys Cys Asn Glu Lys Ser 
            180                 185                 190         


Ser Ser Tyr Arg Tyr Ser Ile Pro Ser His Arg Thr Thr Gln Lys Ser 
        195                 200                 205             


Tyr His Thr Gly Lys Lys Ser Pro Ser Val Tyr Ser Arg Ser Gln Tyr 
    210                 215                 220                 


Val 
225 


<210>  191
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Val Gln Trp Lys Arg Leu Cys Gln Leu His Tyr Leu Trp Ala Leu 
1               5                   10                  15      


Gly Cys Tyr Met Leu Leu Ala Thr Val Ala Leu Lys Leu Ser Phe Arg 
            20                  25                  30          


Leu Lys Cys Asp Ser Asp His Leu Gly Leu Glu Ser Arg Glu Ser Gln 
        35                  40                  45              


Ser Gln Tyr Cys Arg Asn Ile Leu Tyr Asn Phe Leu Lys Leu Pro Ala 
    50                  55                  60                  


Lys Arg Ser Ile Asn Cys Ser Gly Val Thr Arg Gly Asp Gln Glu Ala 
65                  70                  75                  80  


Val Leu Gln Ala Ile Leu Asn Asn Leu Glu Val Lys Lys Lys Arg Glu 
                85                  90                  95      


Pro Phe Thr Asp Thr His Tyr Leu Ser Leu Thr Arg Asp Cys Glu His 
            100                 105                 110         


Phe Lys Ala Glu Arg Lys Phe Ile Gln Phe Pro Leu Ser Lys Glu Glu 
        115                 120                 125             


Val Glu Phe Pro Ile Ala Tyr Ser Met Val Ile His Glu Lys Ile Glu 
    130                 135                 140                 


Asn Phe Glu Arg Leu Leu Arg Ala Val Tyr Ala Pro Gln Asn Ile Tyr 
145                 150                 155                 160 


Cys Val His Val Asp Glu Lys Ser Pro Glu Thr Phe Lys Glu Ala Val 
                165                 170                 175     


Lys Ala Ile Ile Ser Cys Phe Pro Asn Val Phe Ile Ala Ser Lys Leu 
            180                 185                 190         


Val Arg Val Val Tyr Ala Ser Trp Ser Arg Val Gln Ala Asp Leu Asn 
        195                 200                 205             


Cys Met Glu Asp Leu Leu Gln Ser Ser Val Pro Trp Lys Tyr Phe Leu 
    210                 215                 220                 


Asn Thr Cys Gly Thr Asp Phe Pro Ile Lys Ser Asn Ala Glu Met Val 
225                 230                 235                 240 


Gln Ala Leu Lys Met Leu Asn Gly Arg Asn Ser Met Glu Ser Glu Val 
                245                 250                 255     


Pro Pro Lys His Lys Glu Thr Arg Trp Lys Tyr His Phe Glu Val Val 
            260                 265                 270         


Arg Asp Thr Leu His Leu Thr Asn Lys Lys Lys Asp Pro Pro Pro Tyr 
        275                 280                 285             


Asn Leu Thr Met Phe Thr Gly Asn Ala Tyr Ile Val Ala Ser Arg Asp 
    290                 295                 300                 


Phe Val Gln His Val Leu Lys Asn Pro Lys Ser Gln Gln Leu Ile Glu 
305                 310                 315                 320 


Trp Val Lys Asp Thr Tyr Ser Pro Asp Glu His Leu Trp Ala Thr Leu 
                325                 330                 335     


Gln Arg Ala Arg Trp Met Pro Gly Ser Val Pro Asn His Pro Lys Tyr 
            340                 345                 350         


Asp Ile Ser Asp Met Thr Ser Ile Ala Arg Leu Val Lys Trp Gln Gly 
        355                 360                 365             


His Glu Gly Asp Ile Asp Lys Gly Ala Pro Tyr Ala Pro Cys Ser Gly 
    370                 375                 380                 


Ile His Gln Arg Ala Ile Cys Val Tyr Gly Ala Gly Asp Leu Asn Trp 
385                 390                 395                 400 


Met Leu Gln Asn His His Leu Leu Ala Asn Lys Phe Asp Pro Lys Val 
                405                 410                 415     


Asp Asp Asn Ala Leu Gln Cys Leu Glu Glu Tyr Leu Arg Tyr Lys Ala 
            420                 425                 430         


Ile Tyr Gly Thr Glu Leu 
        435             


<210>  192
<211>  1529
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val 
1               5                   10                  15      


Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys 
            20                  25                  30          


Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser 
        35                  40                  45              


Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly 
    50                  55                  60                  


Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His 
65                  70                  75                  80  


Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg 
                85                  90                  95      


Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg 
            100                 105                 110         


Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys 
        115                 120                 125             


Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg 
    130                 135                 140                 


Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr 
145                 150                 155                 160 


Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp 
                165                 170                 175     


Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val 
            180                 185                 190         


Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser 
        195                 200                 205             


Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu 
    210                 215                 220                 


Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser 
225                 230                 235                 240 


His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val 
                245                 250                 255     


Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His 
            260                 265                 270         


Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly 
        275                 280                 285             


Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu 
    290                 295                 300                 


Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe 
305                 310                 315                 320 


Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile 
                325                 330                 335     


Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser 
            340                 345                 350         


Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe 
        355                 360                 365             


Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile 
    370                 375                 380                 


Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu 
385                 390                 395                 400 


Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe 
                405                 410                 415     


Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe 
            420                 425                 430         


Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn 
        435                 440                 445             


Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala 
    450                 455                 460                 


Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala 
465                 470                 475                 480 


Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu 
                485                 490                 495     


Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys 
            500                 505                 510         


Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro 
        515                 520                 525             


Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu 
    530                 535                 540                 


Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu 
545                 550                 555                 560 


Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly 
                565                 570                 575     


Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn 
            580                 585                 590         


Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu 
        595                 600                 605             


Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp 
    610                 615                 620                 


Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn 
625                 630                 635                 640 


Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu 
                645                 650                 655     


Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu 
            660                 665                 670         


Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn 
        675                 680                 685             


Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp 
    690                 695                 700                 


Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser 
705                 710                 715                 720 


Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr 
                725                 730                 735     


Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile 
            740                 745                 750         


Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu 
        755                 760                 765             


Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu 
    770                 775                 780                 


Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met 
785                 790                 795                 800 


Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile 
                805                 810                 815     


Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu 
            820                 825                 830         


His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu 
        835                 840                 845             


Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp 
    850                 855                 860                 


Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu 
865                 870                 875                 880 


Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu 
                885                 890                 895     


Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp 
            900                 905                 910         


Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys 
        915                 920                 925             


Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr 
    930                 935                 940                 


Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala 
945                 950                 955                 960 


Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu 
                965                 970                 975     


Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly 
            980                 985                 990         


Glu Asn Cys Glu Val Asn Val Asp  Asp Cys Glu Asp Asn  Asp Cys Glu 
        995                 1000                 1005             


Asn Asn  Ser Thr Cys Val Asp  Gly Ile Asn Asn Tyr  Thr Cys Leu 
    1010                 1015                 1020             


Cys Pro  Pro Glu Tyr Thr Gly  Glu Leu Cys Glu Glu  Lys Leu Asp 
    1025                 1030                 1035             


Phe Cys  Ala Gln Asp Leu Asn  Pro Cys Gln His Asp  Ser Lys Cys 
    1040                 1045                 1050             


Ile Leu  Thr Pro Lys Gly Phe  Lys Cys Asp Cys Thr  Pro Gly Tyr 
    1055                 1060                 1065             


Val Gly  Glu His Cys Asp Ile  Asp Phe Asp Asp Cys  Gln Asp Asn 
    1070                 1075                 1080             


Lys Cys  Lys Asn Gly Ala His  Cys Thr Asp Ala Val  Asn Gly Tyr 
    1085                 1090                 1095             


Thr Cys  Ile Cys Pro Glu Gly  Tyr Ser Gly Leu Phe  Cys Glu Phe 
    1100                 1105                 1110             


Ser Pro  Pro Met Val Leu Pro  Arg Thr Ser Pro Cys  Asp Asn Phe 
    1115                 1120                 1125             


Asp Cys  Gln Asn Gly Ala Gln  Cys Ile Val Arg Ile  Asn Glu Pro 
    1130                 1135                 1140             


Ile Cys  Gln Cys Leu Pro Gly  Tyr Gln Gly Glu Lys  Cys Glu Lys 
    1145                 1150                 1155             


Leu Val  Ser Val Asn Phe Ile  Asn Lys Glu Ser Tyr  Leu Gln Ile 
    1160                 1165                 1170             


Pro Ser  Ala Lys Val Arg Pro  Gln Thr Asn Ile Thr  Leu Gln Ile 
    1175                 1180                 1185             


Ala Thr  Asp Glu Asp Ser Gly  Ile Leu Leu Tyr Lys  Gly Asp Lys 
    1190                 1195                 1200             


Asp His  Ile Ala Val Glu Leu  Tyr Arg Gly Arg Val  Arg Ala Ser 
    1205                 1210                 1215             


Tyr Asp  Thr Gly Ser His Pro  Ala Ser Ala Ile Tyr  Ser Val Glu 
    1220                 1225                 1230             


Thr Ile  Asn Asp Gly Asn Phe  His Ile Val Glu Leu  Leu Ala Leu 
    1235                 1240                 1245             


Asp Gln  Ser Leu Ser Leu Ser  Val Asp Gly Gly Asn  Pro Lys Ile 
    1250                 1255                 1260             


Ile Thr  Asn Leu Ser Lys Gln  Ser Thr Leu Asn Phe  Asp Ser Pro 
    1265                 1270                 1275             


Leu Tyr  Val Gly Gly Met Pro  Gly Lys Ser Asn Val  Ala Ser Leu 
    1280                 1285                 1290             


Arg Gln  Ala Pro Gly Gln Asn  Gly Thr Ser Phe His  Gly Cys Ile 
    1295                 1300                 1305             


Arg Asn  Leu Tyr Ile Asn Ser  Glu Leu Gln Asp Phe  Gln Lys Val 
    1310                 1315                 1320             


Pro Met  Gln Thr Gly Ile Leu  Pro Gly Cys Glu Pro  Cys His Lys 
    1325                 1330                 1335             


Lys Val  Cys Ala His Gly Thr  Cys Gln Pro Ser Ser  Gln Ala Gly 
    1340                 1345                 1350             


Phe Thr  Cys Glu Cys Gln Glu  Gly Trp Met Gly Pro  Leu Cys Asp 
    1355                 1360                 1365             


Gln Arg  Thr Asn Asp Pro Cys  Leu Gly Asn Lys Cys  Val His Gly 
    1370                 1375                 1380             


Thr Cys  Leu Pro Ile Asn Ala  Phe Ser Tyr Ser Cys  Lys Cys Leu 
    1385                 1390                 1395             


Glu Gly  His Gly Gly Val Leu  Cys Asp Glu Glu Glu  Asp Leu Phe 
    1400                 1405                 1410             


Asn Pro  Cys Gln Ala Ile Lys  Cys Lys His Gly Lys  Cys Arg Leu 
    1415                 1420                 1425             


Ser Gly  Leu Gly Gln Pro Tyr  Cys Glu Cys Ser Ser  Gly Tyr Thr 
    1430                 1435                 1440             


Gly Asp  Ser Cys Asp Arg Glu  Ile Ser Cys Arg Gly  Glu Arg Ile 
    1445                 1450                 1455             


Arg Asp  Tyr Tyr Gln Lys Gln  Gln Gly Tyr Ala Ala  Cys Gln Thr 
    1460                 1465                 1470             


Thr Lys  Lys Val Ser Arg Leu  Glu Cys Arg Gly Gly  Cys Ala Gly 
    1475                 1480                 1485             


Gly Gln  Cys Cys Gly Pro Leu  Arg Ser Lys Arg Arg  Lys Tyr Ser 
    1490                 1495                 1500             


Phe Glu  Cys Thr Asp Gly Ser  Ser Phe Val Asp Glu  Val Glu Lys 
    1505                 1510                 1515             


Val Val  Lys Cys Gly Cys Thr  Arg Cys Val Ser 
    1520                 1525                 


<210>  193
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Tyr Arg Pro Ala Arg Val Thr Ser Thr Ser Arg Phe Leu Asn Pro 
1               5                   10                  15      


Tyr Val Val Cys Phe Ile Val Val Ala Gly Val Val Ile Leu Ala Val 
            20                  25                  30          


Thr Ile Ala Leu Leu Val Tyr Phe Leu Ala Phe Asp Gln Lys Ser Tyr 
        35                  40                  45              


Phe Tyr Arg Ser Ser Phe Gln Leu Leu Asn Val Glu Tyr Asn Ser Gln 
    50                  55                  60                  


Leu Asn Ser Pro Ala Thr Gln Glu Tyr Arg Thr Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Glu Ser Leu Ile Thr Lys Thr Phe Lys Glu Ser Asn Leu Arg Asn Gln 
                85                  90                  95      


Phe Ile Arg Ala His Val Ala Lys Leu Arg Gln Asp Gly Ser Gly Val 
            100                 105                 110         


Arg Ala Asp Val Val Met Lys Phe Gln Phe Thr Arg Asn Asn Asn Gly 
        115                 120                 125             


Ala Ser Met Lys Ser Arg Ile Glu Ser Val Leu Arg Gln Met Leu Asn 
    130                 135                 140                 


Asn Ser Gly Asn Leu Glu Ile Asn Pro Ser Thr Glu Ile Thr Ser Leu 
145                 150                 155                 160 


Thr Asp Gln Ala Ala Ala Asn Trp Leu Ile Asn Glu Cys Gly Ala Gly 
                165                 170                 175     


Pro Asp Leu Ile Thr Leu Ser Glu Gln Arg Ile Leu Gly Gly Thr Glu 
            180                 185                 190         


Ala Glu Glu Gly Ser Trp Pro Trp Gln Val Ser Leu Arg Leu Asn Asn 
        195                 200                 205             


Ala His His Cys Gly Gly Ser Leu Ile Asn Asn Met Trp Ile Leu Thr 
    210                 215                 220                 


Ala Ala His Cys Phe Arg Ser Asn Ser Asn Pro Arg Asp Trp Ile Ala 
225                 230                 235                 240 


Thr Ser Gly Ile Ser Thr Thr Phe Pro Lys Leu Arg Met Arg Val Arg 
                245                 250                 255     


Asn Ile Leu Ile His Asn Asn Tyr Lys Ser Ala Thr His Glu Asn Asp 
            260                 265                 270         


Ile Ala Leu Val Arg Leu Glu Asn Ser Val Thr Phe Thr Lys Asp Ile 
        275                 280                 285             


His Ser Val Cys Leu Pro Ala Ala Thr Gln Asn Ile Pro Pro Gly Ser 
    290                 295                 300                 


Thr Ala Tyr Val Thr Gly Trp Gly Ala Gln Glu Tyr Ala Gly His Thr 
305                 310                 315                 320 


Val Pro Glu Leu Arg Gln Gly Gln Val Arg Ile Ile Ser Asn Asp Val 
                325                 330                 335     


Cys Asn Ala Pro His Ser Tyr Asn Gly Ala Ile Leu Ser Gly Met Leu 
            340                 345                 350         


Cys Ala Gly Val Pro Gln Gly Gly Val Asp Ala Cys Gln Gly Asp Ser 
        355                 360                 365             


Gly Gly Pro Leu Val Gln Glu Asp Ser Arg Arg Leu Trp Phe Ile Val 
    370                 375                 380                 


Gly Ile Val Ser Trp Gly Asp Gln Cys Gly Leu Pro Asp Lys Pro Gly 
385                 390                 395                 400 


Val Tyr Thr Arg Val Thr Ala Tyr Leu Asp Trp Ile Arg Gln Gln Thr 
                405                 410                 415     


Gly Ile 
        


<210>  194
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu 
1               5                   10                  15      


Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg 
            20                  25                  30          


Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile 
        35                  40                  45              


Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  


Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  


Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro 
                85                  90                  95      


Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         


Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             


His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe 
    130                 135                 140                 


Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 


Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser 
                165                 170                 175     


Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         


Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Arg 
        195                 200                 205             


Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 


Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 


Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     


Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         


Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 


Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His 
305                 310                 315                 320 


Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     


Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala 
            340                 345                 350         


Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             


Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 


Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 


Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys 
                405                 410                 415     


Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         


Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             


Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 


Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 


Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     


Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         


Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             


Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 


Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 


Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     


Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly 
            580                 585                 590         


Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             


Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu 
    610                 615                 620                 


Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 


Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     


Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         


Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu 
        675                 680                 685             


Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln 
    690                 695                 700                 


Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 


Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     


Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         


Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu 
        755                 760                 765             


Pro Arg His Thr Leu Asp Ser 
    770                 775 


<210>  195
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Lys Ile Cys Ser Leu Thr Leu Leu Ser Phe Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Val Leu Leu Val Glu Gly Lys Lys Lys Val Lys Asn Gly Leu His 
            20                  25                  30          


Ser Lys Val Val Ser Glu Gln Lys Asp Thr Leu Gly Asn Thr Gln Ile 
        35                  40                  45              


Lys Gln Lys Ser Arg Pro Gly Asn Lys Gly Lys Phe Val Thr Lys Asp 
    50                  55                  60                  


Gln Ala Asn Cys Arg Trp Ala Ala Thr Glu Gln Glu Glu Gly Ile Ser 
65                  70                  75                  80  


Leu Lys Val Glu Cys Thr Gln Leu Asp His Glu Phe Ser Cys Val Phe 
                85                  90                  95      


Ala Gly Asn Pro Thr Ser Cys Leu Lys Leu Lys Asp Glu Arg Val Tyr 
            100                 105                 110         


Trp Lys Gln Val Ala Arg Asn Leu Arg Ser Gln Lys Asp Ile Cys Arg 
        115                 120                 125             


Tyr Ser Lys Thr Ala Val Lys Thr Arg Val Cys Arg Lys Asp Phe Pro 
    130                 135                 140                 


Glu Ser Ser Leu Lys Leu Val Ser Ser Thr Leu Phe Gly Asn Thr Lys 
145                 150                 155                 160 


Pro Arg Lys Glu Lys Thr Glu Met Ser Pro Arg Glu His Ile Lys Gly 
                165                 170                 175     


Lys Glu Thr Thr Pro Ser Ser Leu Ala Val Thr Gln Thr Met Ala Thr 
            180                 185                 190         


Lys Ala Pro Glu Cys Val Glu Asp Pro Asp Met Ala Asn Gln Arg Lys 
        195                 200                 205             


Thr Ala Leu Glu Phe Cys Gly Glu Thr Trp Ser Ser Leu Cys Thr Phe 
    210                 215                 220                 


Phe Leu Ser Ile Val Gln Asp Thr Ser Cys 
225                 230                 


