                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Dowdy, Steven F.
       Yoshioka, Naohisa
 
<120>  GENERATION OF HUMAPN iPS CELLS BY A SYNTHETIC SELF-REPLICATIVE 
       RNA

<130>  00015-219WO1

<140>  Not yet assigned
<141>  2013-05-21

<150>  US 61/649,876
<151>  2012-05-21

<150>  US 61/798,229
<151>  2013-03-15

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  918
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(918)

<400>  1
atg agt gtg gat cca gct tgt ccc caa agc ttg cct tgc ttt gaa gca         48
Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala           
1               5                   10                  15                

tcc gac tgt aaa gaa tct tca cct atg cct gtg att tgt ggg cct gaa         96
Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu           
            20                  25                  30                    

gaa aac tat cca tcc ttg caa atg tct tct gct gag atg cct cac acg        144
Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr           
        35                  40                  45                        

gag act gtc tct cct ctt cct tcc tcc atg gat ctg ctt att cag gac        192
Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp           
    50                  55                  60                            

agc cct gat tct tcc acc agt ccc aaa ggc aaa caa ccc act tct gca        240
Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala           
65                  70                  75                  80            

gag aag agt gtc gca aaa aag gaa gac aag gtc ccg gtc aag aaa cag        288
Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln           
                85                  90                  95                

aag acc aga act gtg ttc tct tcc acc cag ctg tgt gta ctc aat gat        336
Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp           
            100                 105                 110                   

aga ttt cag aga cag aaa tac ctc agc ctc cag cag atg caa gaa ctc        384
Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu           
        115                 120                 125                       

tcc aac atc ctg aac ctc agc tac aaa cag gtg aag acc tgg ttc cag        432
Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln           
    130                 135                 140                           

aac cag aga atg aaa tct aag agg tgg cag aaa aac aac tgg ccg aag        480
Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys           
145                 150                 155                 160           

aat agc aat ggt gtg acg cag aag gcc tca gca cct acc tac ccc agc        528
Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser           
                165                 170                 175               

ctt tac tct tcc tac cac cag gga tgc ctg gtg aac ccg act ggg aac        576
Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn           
            180                 185                 190                   

ctt cca atg tgg agc aac cag acc tgg aac aat tca acc tgg agc aac        624
Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn           
        195                 200                 205                       

cag acc cag aac atc cag tcc tgg agc aac cac tcc tgg aac act cag        672
Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln           
    210                 215                 220                           

acc tgg tgc acc caa tcc tgg aac aat cag gcc tgg aac agt ccc ttc        720
Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe           
225                 230                 235                 240           

tat aac tgt gga gag gaa tct ctg cag tcc tgc atg cag ttc cag cca        768
Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro           
                245                 250                 255               

aat tct cct gcc agt gac ttg gag gct gcc ttg gaa gct gct ggg gaa        816
Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu           
            260                 265                 270                   

ggc ctt aat gta ata cag cag acc act agg tat ttt agt act cca caa        864
Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln           
        275                 280                 285                       

acc atg gat tta ttc cta aac tac tcc atg aac atg caa cct gaa gac        912
Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp           
    290                 295                 300                           

gtg tga                                                                918
Val                                                                       
305                                                                       


<210>  2
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  3
<211>  1083
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1083)

<400>  3
atg gcg gga cac ctg gct tcg gat ttc gcc ttc tcg ccc cct cca ggt         48
Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly           
1               5                   10                  15                

ggt gga ggt gat ggg cca ggg ggg ccg gag ccg ggc tgg gtt gat cct         96
Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro           
            20                  25                  30                    

cgg acc tgg cta agc ttc caa ggc cct cct gga ggg cca gga atc ggg        144
Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly           
        35                  40                  45                        

ccg ggg gtt ggg cca ggc tct gag gtg tgg ggg att ccc cca tgc ccc        192
Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro           
    50                  55                  60                            

ccg ccg tat gag ttc tgt ggg ggg atg gcg tac tgt ggg ccc cag gtt        240
Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val           
65                  70                  75                  80            

gga gtg ggg cta gtg ccc caa ggc ggc ttg gag acc tct cag cct gag        288
Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu           
                85                  90                  95                

ggc gaa gca gga gtc ggg gtg gag agc aac tcc gat ggg gcc tcc ccg        336
Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro           
            100                 105                 110                   

gag ccc tgc acc gtc acc cct ggt gcc gtg aag ctg gag aag gag aag        384
Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys           
        115                 120                 125                       

ctg gag caa aac ccg gag gag tcc cag gac atc aaa gct ctg cag aaa        432
Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys           
    130                 135                 140                           

gaa ctc gag caa ttt gcc aag ctc ctg aag cag aag agg atc acc ctg        480
Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu           
145                 150                 155                 160           

gga tat aca cag gcc gat gtg ggg ctc acc ctg ggg gtt cta ttt ggg        528
Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly           
                165                 170                 175               

aag gta ttc agc caa acg acc atc tgc cgc ttt gag gct ctg cag ctt        576
Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu           
            180                 185                 190                   

agc ttc aag aac atg tgt aag ctg cgg ccc ttg ctg cag aag tgg gtg        624
Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val           
        195                 200                 205                       

gag gaa gct gac aac aat gaa aat ctt cag gag ata tgc aaa gca gaa        672
Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu           
    210                 215                 220                           

acc ctc gtg cag gcc cga aag aga aag cga acc agt atc gag aac cga        720
Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg           
225                 230                 235                 240           

gtg aga ggc aac ctg gag aat ttg ttc ctg cag tgc ccg aaa ccc aca        768
Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr           
                245                 250                 255               

ctg cag cag atc agc cac atc gcc cag cag ctt ggg ctc gag aag gat        816
Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp           
            260                 265                 270                   

gtg gtc cga gtg tgg ttc tgt aac cgg cgc cag aag ggc aag cga tca        864
Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser           
        275                 280                 285                       

agc agc gac tat gca caa cga gag gat ttt gag gct gct ggg tct cct        912
Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro           
    290                 295                 300                           

ttc tca ggg gga cca gtg tcc ttt cct ctg gcc cca ggg ccc cat ttt        960
Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe           
305                 310                 315                 320           

ggt acc cca ggc tat ggg agc cct cac ttc act gca ctg tac tcc tcg       1008
Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser           
                325                 330                 335               

gtc cct ttc cct gag ggg gaa gcc ttt ccc cct gtc tcc gtc acc act       1056
Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr           
            340                 345                 350                   

ctg ggc tct ccc atg cat tca aac tga                                   1083
Leu Gly Ser Pro Met His Ser Asn                                           
        355                 360                                           


<210>  4
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  5
<211>  954
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(954)

<400>  5
atg tac aac atg atg gag acg gag ctg aag ccg ccg ggc ccg cag caa         48
Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln           
1               5                   10                  15                

act tcg ggg ggc ggc ggc ggc aac tcc acc gcg gcg gcg gcc ggc ggc         96
Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly           
            20                  25                  30                    

aac cag aaa aac agc ccg gac cgc gtc aag cgg ccc atg aat gcc ttc        144
Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe           
        35                  40                  45                        

atg gtg tgg tcc cgc ggg cag cgg cgc aag atg gcc cag gag aac ccc        192
Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro           
    50                  55                  60                            

aag atg cac aac tcg gag atc agc aag cgc ctg ggc gcc gag tgg aaa        240
Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys           
65                  70                  75                  80            

ctt ttg tcg gag acg gag aag cgg ccg ttc atc gac gag gct aag cgg        288
Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg           
                85                  90                  95                

ctg cga gcg ctg cac atg aag gag cac ccg gat tat aaa tac cgg ccc        336
Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro           
            100                 105                 110                   

cgg cgg aaa acc aag acg ctc atg aag aag gat aag tac acg ctg ccc        384
Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro           
        115                 120                 125                       

ggc ggg ctg ctg gcc ccc ggc ggc aat agc atg gcg agc ggg gtc ggg        432
Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly           
    130                 135                 140                           

gtg ggc gcc ggc ctg ggc gcg ggc gtg aac cag cgc atg gac agt tac        480
Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr           
145                 150                 155                 160           

gcg cac atg aac ggc tgg agc aac ggc agc tac agc atg atg cag gac        528
Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp           
                165                 170                 175               

cag ctg ggc tac ccg cag cac ccg ggc ctc aat gcg cac ggc gca gcg        576
Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala           
            180                 185                 190                   

cag atg cag ccc atg cac cgc tac gac gtg agc gcc ctg cag tac aac        624
Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn           
        195                 200                 205                       

tcc atg acc agc tcg cag acc tac atg aac ggc tcg ccc acc tac agc        672
Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser           
    210                 215                 220                           

atg tcc tac tcg cag cag ggc acc cct ggc atg gct ctt ggc tcc atg        720
Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met           
225                 230                 235                 240           

ggt tcg gtg gtc aag tcc gag gcc agc tcc agc ccc cct gtg gtt acc        768
Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr           
                245                 250                 255               

tct tcc tcc cac tcc agg gcg ccc tgc cag gcc ggg gac ctc cgg gac        816
Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp           
            260                 265                 270                   

atg atc agc atg tat ctc ccc ggc gcc gag gtg ccg gaa ccc gcc gcc        864
Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala           
        275                 280                 285                       

ccc agc aga ctt cac atg tcc cag cac tac cag agc ggc ccg gtg ccc        912
Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro           
    290                 295                 300                           

ggc acg gcc att aac ggc aca ctg ccc ctc tca cac atg tga                954
Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met                       
305                 310                 315                               


<210>  6
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  7
<211>  1440
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1440)

<400>  7
atg agg cag cca cct ggc gag tct gac atg gct gtc agc gac gcg ctg         48
Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu           
1               5                   10                  15                

ctc cca tct ttc tcc acg ttc gcg tct ggc ccg gcg gga agg gag aag         96
Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys           
            20                  25                  30                    

aca ctg cgt caa gca ggt gcc ccg aat aac cgc tgg cgg gag gag ctc        144
Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu           
        35                  40                  45                        

tcc cac atg aag cga ctt ccc cca gtg ctt ccc ggc cgc ccc tat gac        192
Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp           
    50                  55                  60                            

ctg gcg gcg gcg acc gtg gcc aca gac ctg gag agc ggc gga gcc ggt        240
Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly           
65                  70                  75                  80            

gcg gct tgc ggc ggt agc aac ctg gcg ccc cta cct cgg aga gag acc        288
Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr           
                85                  90                  95                

gag gag ttc aac gat ctc ctg gac ctg gac ttt att ctc tcc aat tcg        336
Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser           
            100                 105                 110                   

ctg acc cat cct ccg gag tca gtg gcc gcc acc gtg tcc tcg tca gcg        384
Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala           
        115                 120                 125                       

tca gcc tcc tct tcg tcg tcg ccg tcg agc agc ggc cct gcc agc gcg        432
Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala           
    130                 135                 140                           

ccc tcc acc tgc agc ttc acc tat ccg atc cgg gcc ggg aac gac ccg        480
Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro           
145                 150                 155                 160           

ggc gtg gcg ccg ggc ggc acg ggc gga ggc ctc ctc tat ggc agg gag        528
Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu           
                165                 170                 175               

tcc gct ccc cct ccg acg gct ccc ttc aac ctg gcg gac atc aac gac        576
Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp           
            180                 185                 190                   

gtg agc ccc tcg ggc ggc ttc gtg gcc gag ctc ctg cgg cca gaa ttg        624
Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu           
        195                 200                 205                       

gac ccg gtg tac att ccg ccg cag cag ccg cag ccg cca ggt ggc ggg        672
Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly           
    210                 215                 220                           

ctg atg ggc aag ttc gtg ctg aag gcg tcg ctg agc gcc cct ggc agc        720
Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser           
225                 230                 235                 240           

gag tac ggc agc ccg tcg gtc atc agc gtc agc aaa ggc agc cct gac        768
Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp           
                245                 250                 255               

ggc agc cac ccg gtg gtg gtg gcg ccc tac aac ggc ggg ccg ccg cgc        816
Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg           
            260                 265                 270                   

acg tgc ccc aag atc aag cag gag gcg gtc tct tcg tgc acc cac ttg        864
Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu           
        275                 280                 285                       

ggc gct gga ccc cct ctc agc aat ggc cac cgg ccg gct gca cac gac        912
Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp           
    290                 295                 300                           

ttc ccc ctg ggg cgg cag ctc ccc agc agg act acc ccg acc ctg ggt        960
Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly           
305                 310                 315                 320           

ctt gag gaa gtg ctg agc agc agg gac tgt cac cct gcc ctg ccg ctt       1008
Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu           
                325                 330                 335               

cct ccc ggc ttc cat ccc cac ccg ggg ccc aat tac cca tcc ttc ctg       1056
Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu           
            340                 345                 350                   

ccc gat cag atg cag ccg caa gtc ccg ccg ctc cat tac caa gag ctc       1104
Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu           
        355                 360                 365                       

atg cca ccc ggt tcc tgc atg cca gag gag ccc aag cca aag agg gga       1152
Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly           
    370                 375                 380                           

aga cga tcg tgg ccc cgg aaa agg acc gcc acc cac act tgt gat tac       1200
Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr           
385                 390                 395                 400           

gcg ggc tgc ggc aaa acc tac aca aag agt tcc cat ctc aag gca cac       1248
Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His           
                405                 410                 415               

ctg cga acc cac aca ggt gag aaa cct tac cac tgt gac tgg gac ggc       1296
Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly           
            420                 425                 430                   

tgt gga tgg aaa ttc gcc cgc tca gat gaa ctg acc agg cac tac cgt       1344
Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg           
        435                 440                 445                       

aaa cac acg ggg cac cgc ccg ttc cag tgc caa aaa tgc gac cga gca       1392
Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala           
    450                 455                 460                           

ttt tcc agg tcg gac cac ctc gcc tta cac atg aag agg cat ttt taa       1440
Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe               
465                 470                 475                               


<210>  8
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  9
<211>  1323
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1323)

<400>  9
atg ggc ccc ctc aac gtt agc ttc acc aac agg aac tat gac ctc gac         48
Met Gly Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp           
1               5                   10                  15                

tac gac tcg gtg cag ccg tat ttc tac tgc gac gag gag gag aac ttc         96
Tyr Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe           
            20                  25                  30                    

tac cag cag cag cag cag agc gag ctg cag ccc ccg gcg ccc agc gag        144
Tyr Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu           
        35                  40                  45                        

gat atc tgg aag aaa ttc gag ctg ctg ccc acc ccg ccc ctg tcc cct        192
Asp Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro           
    50                  55                  60                            

agc cgc cgc tcc ggg ctc tgc tcg ccc tcc tac gtt gcg gtc aca ccc        240
Ser Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro           
65                  70                  75                  80            

ttc tcc ctt cgg gga gac aac gac ggc ggt ggc ggg agc ttc tcc acg        288
Phe Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr           
                85                  90                  95                

gcc gac cag ctg gag atg gtg acc gag ctg ctg gga gga gac atg gtg        336
Ala Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val           
            100                 105                 110                   

aac cag agt ttc atc tgc gac ccg gac gac gag acc ttc atc aaa aac        384
Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn           
        115                 120                 125                       

atc atc atc cag gac tgt atg tgg agc ggc ttc tcg gcc gcc gcc aag        432
Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys           
    130                 135                 140                           

ctc gtc tca gag aag ctg gcc tcc tac cag gct gcg cgc aaa gac agc        480
Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser           
145                 150                 155                 160           

ggc agc ccg aac ccc gcc cgc ggc cac agc gtc tgc tcc acc tcc agc        528
Gly Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser           
                165                 170                 175               

ttg tac ctg cag gat ctg agc gcc gcc gcc tca gag tgc atc gac ccc        576
Leu Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro           
            180                 185                 190                   

tcg gtg gtc ttc ccc tac cct ctc aac gac agc agc tcg ccc aag tcc        624
Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser           
        195                 200                 205                       

tgc gcc tcg caa gac tcc agc gcc ttc tct ccg tcc tcg gat tct ctg        672
Cys Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu           
    210                 215                 220                           

ctc tcc tcg acg gag tcc tcc ccg cag ggc agc ccc gag ccc ctg gtg        720
Leu Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val           
225                 230                 235                 240           

ctc cat gag gag aca ccg ccc acc acc agc agc gac tct gag gag gaa        768
Leu His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu           
                245                 250                 255               

caa gaa gat gag gaa gaa atc gat gtt gtt tct gtg gaa aag agg cag        816
Gln Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln           
            260                 265                 270                   

gct cct ggc aaa agg tca gag tct gga tca cct tct gct gga ggc cac        864
Ala Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His           
        275                 280                 285                       

agc aaa cct cct cac agc cca ctg gtc ctc aag agg tgc cac gtc tcc        912
Ser Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser           
    290                 295                 300                           

aca cat cag cac aac tac gca gcg cct ccc tcc act cgg aag gac tat        960
Thr His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr           
305                 310                 315                 320           

cct gct gcc aag agg gtc aag ttg gac agt gtc aga gtc ctg aga cag       1008
Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln           
                325                 330                 335               

atc agc aac aac cga aaa tgc acc agc ccc agg tcc tcg gac acc gag       1056
Ile Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu           
            340                 345                 350                   

gag aat gtc aag agg cga aca cac aac gtc ttg gag cgc cag agg agg       1104
Glu Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg           
        355                 360                 365                       

aac gag cta aaa cgg agc ttt ttt gcc ctg cgt gac cag atc ccg gag       1152
Asn Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu           
    370                 375                 380                           

ttg gaa aac aat gaa aag gcc ccc aag gta gtt atc ctt aaa aaa gcc       1200
Leu Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala           
385                 390                 395                 400           

aca gca tac atc ctg tcc gtc caa gca gag gag caa aag ctc att tct       1248
Thr Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser           
                405                 410                 415               

gaa gag gac ttg ttg cgg aaa cga cga gaa cag ttg aaa cac aaa ctt       1296
Glu Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu           
            420                 425                 430                   

gaa cag cta cgg aac tct tgt gcg taa                                   1323
Glu Gln Leu Arg Asn Ser Cys Ala                                           
        435                 440                                           


<210>  10
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp 
1               5                   10                  15      


Tyr Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe 
            20                  25                  30          


Tyr Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu 
        35                  40                  45              


Asp Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro 
    50                  55                  60                  


Ser Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro 
65                  70                  75                  80  


Phe Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr 
                85                  90                  95      


Ala Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val 
            100                 105                 110         


Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn 
        115                 120                 125             


Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys 
    130                 135                 140                 


Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser 
145                 150                 155                 160 


Gly Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser 
                165                 170                 175     


Leu Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro 
            180                 185                 190         


Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser 
        195                 200                 205             


Cys Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu 
    210                 215                 220                 


Leu Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val 
225                 230                 235                 240 


Leu His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu 
                245                 250                 255     


Gln Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln 
            260                 265                 270         


Ala Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His 
        275                 280                 285             


Ser Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser 
    290                 295                 300                 


Thr His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr 
305                 310                 315                 320 


Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln 
                325                 330                 335     


Ile Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu 
            340                 345                 350         


Glu Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg 
        355                 360                 365             


Asn Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu 
    370                 375                 380                 


Leu Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala 
385                 390                 395                 400 


Thr Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser 
                405                 410                 415     


Glu Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu 
            420                 425                 430         


Glu Gln Leu Arg Asn Ser Cys Ala 
        435                 440 


<210>  11
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Forward F2A

<400>  11
aattcaccgg tgtgaaacag actttgaatt ttgaccttct caagttggcg ggagacgtgg       60

agtccaaccc agggcccaga tcta                                              84


<210>  12
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse F2A

<400>  12
ctagtagatc tgggccctgg gttggactcc acgtctcccg ccaacttgag aaggtcaaaa       60

ttcaaagtct gtttcacacc ggtg                                              84


<210>  13
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - Forward T2A

<400>  13
ctagtgaggg cagaggaagt ctgctaacat gcggtgacgt cgaggagaat cctggcccac       60

aattgt                                                                  66


<210>  14
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse T2A

<400>  14
ctagacaatt gtgggccagg attctcctcg acgtcaccgc atgttagcag acttcctctg       60

ccctca                                                                  66


<210>  15
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - Forward E2A

<400>  15
ctagacaatg tactaactac gctttgttga aactcgctgg cgatgttgaa agtaaccccg       60

gtcctggcgc gcccgc                                                       76


<210>  16
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse E2A

<400>  16
ggccgcgggc gcgccaggac cggggttact ttcaacatcg ccagcgagtt tcaacaaagc       60

gtagttagta cattgt                                                       76


<210>  17
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Forward VEE-MCS

<400>  17
ctagcatatg ggcgcgccct cagcatcgat ggccggcctc tagagcggcc gc               52


<210>  18
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse VEE-MCS

<400>  18
ggccgcggcc gctctagagg ccggccatcg atgctgaggg cgcgcccata tg               52


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Forward nsP2a

<400>  19
caggacgatc tcattctcac                                                   20


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse nsP2a

<400>  20
gcttgccact cctctatcgt g                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Forward nsP4a

<400>  21
ccacaatacg atcggcagtg                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Reverse nsP4a

<400>  22
atgtcctgca acatattcaa a                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Forward Oct4RTa

<400>  23
cggcgccaga agggcaagcg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Klf4RTb

<400>  24
cacctgcttg acgcagtgtc                                                   20


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Bis-Oct-10F

<400>  25
ggagtagaag gattgttttg gttta                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Bis-Oct-9R

<400>  26
aaaccttaaa aacttaacca aatcc                                             25


<210>  27
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Bis-Nanog-4F

<400>  27
agagtagttg ggattataga tattta                                            26


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Bis-Nanog-3R

<400>  28
aacaacaaaa cctaaaaaca aacc                                              24


<210>  29
<211>  16337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEE-Oct-Klf-Sox-cMyc

<400>  29
atgggcggcg catgagagaa gcccagacca attacctacc caaaatggag aaagttcacg       60

ttgacatcga ggaagacagc ccattcctca gagctttgca gcggagcttc ccgcagtttg      120

aggtagaagc caagcaggtc actgataatg accatgctaa tgccagagcg ttttcgcatc      180

tggcttcaaa actgatcgaa acggaggtgg acccatccga cacgatcctt gacattggaa      240

gtgcgcccgc ccgcagaatg tattctaagc acaagtatca ttgtatctgt ccgatgagat      300

gtgcggaaga tccggacaga ttgtataagt atgcaactaa gctgaagaaa aactgtaagg      360

aaataactga taaggaattg gacaagaaaa tgaaggagct ggccgccgtc atgagcgacc      420

ctgacctgga aactgagact atgtgcctcc acgacgacga gtcgtgtcgc tacgaagggc      480

aagtcgctgt ttaccaggat gtatacgcgg ttgacggacc gacaagtctc tatcaccaag      540

ccaataaggg agttagagtc gcctactgga taggctttga caccacccct tttatgttta      600

agaacttggc tggagcatat ccatcatact ctaccaactg ggccgacgaa accgtgttaa      660

cggctcgtaa cataggccta tgcagctctg acgttatgga gcggtcacgt agagggatgt      720

ccattcttag aaagaagtat ttgaaaccat ccaacaatgt tctattctct gttggctcga      780

ccatctacca cgagaagagg gacttactga ggagctggca cctgccgtct gtatttcact      840

tacgtggcaa gcaaaattac acatgtcggt gtgagactat agttagttgc gacgggtacg      900

tcgttaaaag aatagctatc agtccaggcc tgtatgggaa gccttcaggc tatgctgcta      960

cgatgcaccg cgagggattc ttgtgctgca aagtgacaga cacattgaac ggggagaggg     1020

tctcttttcc cgtgtgcacg tatgtgccag ctacattgtg tgaccaaatg actggcatac     1080

tggcaacaga tgtcagtgcg gacgacgcgc aaaaactgct ggttgggctc aaccagcgta     1140

tagtcgtcaa cggtcgcacc cagagaaaca ccaataccat gaaaaattac cttttgcccg     1200

tagtggccca ggcatttgct aggtgggcaa aggaatataa ggaagatcaa gaagatgaaa     1260

ggccactagg actacgagat agacagttag tcatggggtg ttgttgggct tttagaaggc     1320

acaagataac atctatttat aagcgcccgg atacccaaac catcatcaaa gtgaacagcg     1380

atttccactc attcgtgctg cccaggatag gcagtaacac attggagatc gggctgagaa     1440

caagaatcag gaaaatgtta gaggagcaca aggagccgtc acctctcatt accgccgagg     1500

acgtacaaga agctaagtgc gcagccgatg aggctaagga ggtgcgtgaa gccgaggagt     1560

tgcgcgcagc tctaccacct ttggcagctg atgttgagga gcccactctg gaagccgatg     1620

tcgacttgat gttacaagag gctggggccg gctcagtgga gacacctcgt ggcttgataa     1680

aggttaccag ctacgatggc gaggacaaga tcggctctta cgctgtgctt tctccgcagg     1740

ctgtactcaa gagtgaaaaa ttatcttgca tccaccctct cgctgaacaa gtcatagtga     1800

taacacactc tggccgaaaa gggcgttatg ccgtggaacc ataccatggt aaagtagtgg     1860

tgccagaggg acatgcaata cccgtccagg actttcaagc tctgagtgaa agtgccacca     1920

ttgtgtacaa cgaacgtgag ttcgtaaaca ggtacctgca ccatattgcc acacatggag     1980

gagcgctgaa cactgatgaa gaatattaca aaactgtcaa gcccagcgag cacgacggcg     2040

aatacctgta cgacatcgac aggaaacagt gcgtcaagaa agaactagtc actgggctag     2100

ggctcacagg cgagctggtg gatcctccct tccatgaatt cgcctacgag agtctgagaa     2160

cacgaccagc cgctccttac caagtaccaa ccataggggt gtatggcgtg ccaggatcag     2220

gcaagtctgg catcattaaa agcgcagtca ccaaaaaaga tctagtggtg agcgccaaga     2280

aagaaaactg tgcagaaatt ataagggacg tcaagaaaat gaaagggctg gacgtcaatg     2340

ccagaactgt ggactcagtg ctcttgaatg gatgcaaaca ccccgtagag accctgtata     2400

ttgacgaagc ttttgcttgt catgcaggta ctctcagagc gctcatagcc attataagac     2460

ctaaaaaggc agtgctctgc ggggatccca aacagtgcgg tttttttaac atgatgtgcc     2520

tgaaagtgca ttttaaccac gagatttgca cacaagtctt ccacaaaagc atctctcgcc     2580

gttgcactaa atctgtgact tcggtcgtct caaccttgtt ttacgacaaa aaaatgagaa     2640

cgacgaatcc gaaagagact aagattgtga ttgacactac cggcagtacc aaacctaagc     2700

aggacgatct cattctcact tgtttcagag ggtgggtgaa gcagttgcaa atagattaca     2760

aaggcaacga aataatgacg gcagctgcct ctcaagggct gacccgtaaa ggtgtgtatg     2820

ccgttcggta caaggtgaat gaaaatcctc tgtacgcacc cacctcagaa catgtgaacg     2880

tcctactgac ccgcacggag gaccgcatcg tgtggaaaac actagccggc gacccatgga     2940

taaaaacact gactgccaag taccctggga atttcactgc cacgatagag gagtggcaag     3000

cagagcatga tgccatcatg aggcacatct tggagagacc ggaccctacc gacgtcttcc     3060

agaataaggc aaacgtgtgt tgggccaagg ctttagtgcc ggtgctgaag accgctggca     3120

tagacatgac cactgaacaa tggaacactg tggattattt tgaaacggac aaagctcact     3180

cagcagagat agtattgaac caactatgcg tgaggttctt tggactcgat ctggactccg     3240

gtctattttc tgcacccact gttccgttat ccattaggaa taatcactgg gataactccc     3300

cgtcgcctaa catgtacggg ctgaataaag aagtggtccg tcagctctct cgcaggtacc     3360

cacaactgcc tcgggcagtt gccactggaa gagtctatga catgaacact ggtacactgc     3420

gcaattatga tccgcgcata aacctagtac ctgtaaacag aagactgcct catgctttag     3480

tcctccacca taatgaacac ccacagagtg acttttcttc attcgtcagc aaattgaagg     3540

gcagaactgt cctggtggtc ggggaaaagt tgtccgtccc aggcaaaatg gttgactggt     3600

tgtcagaccg gcctgaggct accttcagag ctcggctgga tttaggcatc ccaggtgatg     3660

tgcccaaata tgacataata tttgttaatg tgaggacccc atataaatac catcactatc     3720

agcagtgtga agaccatgcc attaagctta gcatgttgac caagaaagct tgtctgcatc     3780

tgaatcccgg cggaacctgt gtcagcatag gttatggtta cgctgacagg gccagcgaaa     3840

gcatcattgg tgctatagcg cggcagttca agttttcccg ggtatgcaaa ccgaaatcct     3900

cacttgaaga gacggaagtt ctgtttgtat tcattgggta cgatcgcaag gcccgtacgc     3960

acaattctta caagctttca tcaaccttga ccaacattta tacaggttcc agactccacg     4020

aagccggatg tgcaccctca tatcatgtgg tgcgagggga tattgccacg gccaccgaag     4080

gagtgattat aaatgctgct aacagcaaag gacaacctgg cggaggggtg tgcggagcgc     4140

tgtataagaa attcccggaa agcttcgatt tacagccgat cgaagtagga aaagcgcgac     4200

tggtcaaagg tgcagctaaa catatcattc atgccgtagg accaaacttc aacaaagttt     4260

cggaggttga aggtgacaaa cagttggcag aggcttatga gtccatcgct aagattgtca     4320

acgataacaa ttacaagtca gtagcgattc cactgttgtc caccggcatc ttttccggga     4380

acaaagatcg actaacccaa tcattgaacc atttgctgac agctttagac accactgatg     4440

cagatgtagc catatactgc agggacaaga aatgggaaat gactctcaag gaagcagtgg     4500

ctaggagaga agcagtggag gagatatgca tatccgacga ctcttcagtg acagaacctg     4560

atgcagagct ggtgagggtg catccgaaga gttctttggc tggaaggaag ggctacagca     4620

caagcgatgg caaaactttc tcatatttgg aagggaccaa gtttcaccag gcggccaagg     4680

atatagcaga aattaatgcc atgtggcccg ttgcaacgga ggccaatgag caggtatgca     4740

tgtatatcct cggagaaagc atgagcagta ttaggtcgaa atgccccgtc gaagagtcgg     4800

aagcctccac accacctagc acgctgcctt gcttgtgcat ccatgccatg actccagaaa     4860

gagtacagcg cctaaaagcc tcacgtccag aacaaattac tgtgtgctca tcctttccat     4920

tgccgaagta tagaatcact ggtgtgcaga agatccaatg ctcccagcct atattgttct     4980

caccgaaagt gcctgcgtat attcatccaa ggaagtatct cgtggaaaca ccaccggtag     5040

acgagactcc ggagccatcg gcagagaacc aatccacaga ggggacacct gaacaaccac     5100

cacttataac cgaggatgag accaggacta gaacgcctga gccgatcatc atcgaagagg     5160

aagaagagga tagcataagt ttgctgtcag atggcccgac ccaccaggtg ctgcaagtcg     5220

aggcagacat tcacgggccg ccctctgtat ctagctcatc ctggtccatt cctcatgcat     5280

ccgactttga tgtggacagt ttatccatac ttgacaccct ggagggagct agcgtgacca     5340

gcggggcaac gtcagccgag actaactctt acttcgcaaa gagtatggag tttctggcgc     5400

gaccggtgcc tgcgcctcga acagtattca ggaaccctcc acatcccgct ccgcgcacaa     5460

gaacaccgtc acttgcaccc agcagggcct gctcgagaac cagcctagtt tccaccccgc     5520

caggcgtgaa tagggtgatc actagagagg agctcgaggc gcttaccccg tcacgcactc     5580

ctagcaggtc ggtctcgaga accagcctgg tctccaaccc gccaggcgta aatagggtga     5640

ttacaagaga ggagtttgag gcgttcgtag cacaacaaca atgacggttt gatgcgggtg     5700

catacatctt ttcctccgac accggtcaag ggcatttaca acaaaaatca gtaaggcaaa     5760

cggtgctatc cgaagtggtg ttggagagga ccgaattgga gatttcgtat gccccgcgcc     5820

tcgaccaaga aaaagaagaa ttactacgca agaaattaca gttaaatccc acacctgcta     5880

acagaagcag ataccagtcc aggaaggtgg agaacatgaa agccataaca gctagacgta     5940

ttctgcaagg cctagggcat tatttgaagg cagaaggaaa agtggagtgc taccgaaccc     6000

tgcatcctgt tcctttgtat tcatctagtg tgaaccgtgc cttttcaagc cccaaggtcg     6060

cagtggaagc ctgtaacgcc atgttgaaag agaactttcc gactgtggct tcttactgta     6120

ttattccaga gtacgatgcc tatttggaca tggttgacgg agcttcatgc tgcttagaca     6180

ctgccagttt ttgccctgca aagctgcgca gctttccaaa gaaacactcc tatttggaac     6240

ccacaatacg atcggcagtg ccttcagcga tccagaacac gctccagaac gtcctggcag     6300

ctgccacaaa aagaaattgc aatgtcacgc aaatgagaga attgcccgta ttggattcgg     6360

cggcctttaa tgtggaatgc ttcaagaaat atgcgtgtaa taatgaatat tgggaaacgt     6420

ttaaagaaaa ccccatcagg cttactgaag aaaacgtggt aaattacatt accaaattaa     6480

aaggaccaaa agctgctgct ctttttgcga agacacataa tttgaatatg ttgcaggaca     6540

taccaatgga caggtttgta atggacttaa agagagacgt gaaagtgact ccaggaacaa     6600

aacatactga agaacggccc aaggtacagg tgatccaggc tgccgatccg ctagcaacag     6660

cgtatctgtg cggaatccac cgagagctgg ttaggagatt aaatgcggtc ctgcttccga     6720

acattcatac actgtttgat atgtcggctg aagactttga cgctattata gccgagcact     6780

tccagcctgg ggattgtgtt ctggaaactg acatcgcgtc gtttgataaa agtgaggacg     6840

acgccatggc tctgaccgcg ttaatgattc tggaagactt aggtgtggac gcagagctgt     6900

tgacgctgat tgaggcggct ttcggcgaaa tttcatcaat acatttgccc actaaaacta     6960

aatttaaatt cggagccatg atgaaatctg gaatgttcct cacactgttt gtgaacacag     7020

tcattaacat tgtaatcgca agcagagtgt tgagagaacg gctaaccgga tcaccatgtg     7080

cagcattcat tggagatgac aatatcgtga aaggagtcaa atcggacaaa ttaatggcag     7140

acaggtgcgc cacctggttg aatatggaag tcaagattat agatgctgtg gtgggcgaga     7200

aagcgcctta tttctgtgga gggtttattt tgtgtgactc cgtgaccggc acagcgtgcc     7260

gtgtggcaga ccccctaaaa aggctgttta agcttggcaa acctctggca gcagacgatg     7320

aacatgatga tgacaggaga agggcattgc atgaagagtc aacacgctgg aaccgagtgg     7380

gtattctttc agagctgtgc aaggcagtag aatcaaggta tgaaaccgta ggaacttcca     7440

tcatagttat ggccatgact actctagcta gcagtgttaa atcattcagc tacctgagag     7500

gggcccctat aactctctac ggctaacctg aatggactac gacatagtct agtccgccaa     7560

gtctagcata tgggcgcgtg aattcgccac catggcggga cacctggctt cggatttcgc     7620

cttctcgccc cctccaggtg gtggaggtga tgggccaggg gggccggagc cgggctgggt     7680

tgatcctcgg acctggctaa gcttccaagg ccctcctgga gggccaggaa tcgggccggg     7740

ggttgggcca ggctctgagg tgtgggggat tcccccatgc cccccgccgt atgagttctg     7800

tggggggatg gcgtactgtg ggccccaggt tggagtgggg ctagtgcccc aaggcggctt     7860

ggagacctct cagcctgagg gcgaagcagg agtcggggtg gagagcaact ccgatggggc     7920

ctccccggag ccctgcaccg tcacccctgg tgccgtgaag ctggagaagg agaagctgga     7980

gcaaaacccg gaggagtccc aggacatcaa agctctgcag aaagaactcg agcaatttgc     8040

caagctcctg aagcagaaga ggatcaccct gggatataca caggccgatg tggggctcac     8100

cctgggggtt ctatttggga aggtattcag ccaaacgacc atctgccgct ttgaggctct     8160

gcagcttagc ttcaagaaca tgtgtaagct gcggcccttg ctgcagaagt gggtggagga     8220

agctgacaac aatgaaaatc ttcaggagat atgcaaagca gaaaccctcg tgcaggcccg     8280

aaagagaaag cgaaccagta tcgagaaccg agtgagaggc aacctggaga atttgttcct     8340

gcagtgcccg aaacccacac tgcagcagat cagccacatc gcccagcagc ttgggctcga     8400

gaaggatgtg gtccgagtgt ggttctgtaa ccggcgccag aagggcaagc gatcaagcag     8460

cgactatgca caacgagagg attttgaggc tgctgggtct cctttctcag ggggaccagt     8520

gtcctttcct ctggccccag ggccccattt tggtacccca ggctatggga gccctcactt     8580

cactgcactg tactcctcgg tccctttccc tgagggggaa gcctttcccc ctgtctccgt     8640

caccactctg ggctctccca tgcattcaaa ctctagtgag ggcagaggaa gtctgctaac     8700

atgcggtgac gtcgaggaga atcctggccc acaattgatg gctgtcagcg acgcgctgct     8760

cccatctttc tccacgttcg cgtctggccc ggcgggaagg gagaagacac tgcgtcaagc     8820

aggtgccccg aataaccgct ggcgggagga gctctcccac atgaagcgac ttcccccagt     8880

gcttcccggc cgcccctatg acctggcggc ggcgaccgtg gccacagacc tggagagcgg     8940

cggagccggt gcggcttgcg gcggtagcaa cctggcgccc ctacctcgga gagagaccga     9000

ggagttcaac gatctcctgg acctggactt tattctctcc aattcgctga cccatcctcc     9060

ggagtcagtg gccgccaccg tgtcctcgtc agcgtcagcc tcctcttcgt cgtcgccgtc     9120

gagcagcggc cctgccagcg cgccctccac ctgcagcttc acctatccga tccgggccgg     9180

gaacgacccg ggcgtggcgc cgggcggcac gggcggaggc ctcctctatg gcagggagtc     9240

cgctccccct ccgacggctc ccttcaacct ggcggacatc aacgacgtga gcccctcggg     9300

cggcttcgtg gccgagctcc tgcggccaga attggacccg gtgtacattc cgccgcagca     9360

gccgcagccg ccaggtggcg ggctgatggg caagttcgtg ctgaaggcgt cgctgagcgc     9420

ccctggcagc gagtacggca gcccgtcggt catcagcgtc agcaaaggca gccctgacgg     9480

cagccacccg gtggtggtgg cgccctacaa cggcgggccg ccgcgcacgt gccccaagat     9540

caagcaggag gcggtctctt cgtgcaccca cttgggcgct ggaccccctc tcagcaatgg     9600

ccaccggccg gctgcacacg acttccccct ggggcggcag ctccccagca ggactacccc     9660

gaccctgggt cttgaggaag tgctgagcag cagggactgt caccctgccc tgccgcttcc     9720

tcccggcttc catccccacc cggggcccaa ttacccatcc ttcctgcccg atcagatgca     9780

gccgcaagtc ccgccgctcc attaccaaga gctcatgcca cccggttcct gcatgccaga     9840

ggagcccaag ccaaagaggg gaagacgatc gtggccccgg aaaaggaccg ccacccacac     9900

ttgtgattac gcgggctgcg gcaaaaccta cacaaagagt tcccatctca aggcacacct     9960

gcgaacccac acaggtgaga aaccttacca ctgtgactgg gacggctgtg gatggaaatt    10020

cgcccgctca gatgaactga ccaggcacta ccgtaaacac acggggcacc gcccgttcca    10080

gtgccaaaaa tgcgaccgag cattttccag gtcggaccac ctcgccttac acatgaagag    10140

gcatttttct agacaatgta ctaactacgc tttgttgaaa ctcgctggcg atgttgaaag    10200

taaccccggt cctggcgcgc ccatgtacaa catgatggag acggagctga agccgccggg    10260

cccgcagcaa acttcggggg gcggcggcgg caactccacc gcggcggcgg ccggcggcaa    10320

ccagaaaaac agcccggacc gcgtcaagcg gcccatgaat gccttcatgg tgtggtcccg    10380

cgggcagcgg cgcaagatgg cccaggagaa ccccaagatg cacaactcgg agatcagcaa    10440

gcgcctgggc gccgagtgga aacttttgtc ggagacggag aagcggccgt tcatcgacga    10500

ggctaagcgg ctgcgagcgc tgcacatgaa ggagcacccg gattataaat accggccccg    10560

gcggaaaacc aagacgctca tgaagaagga taagtacacg ctgcccggcg ggctgctggc    10620

ccccggcggc aatagcatgg cgagcggggt cggggtgggc gccggcctgg gcgcgggcgt    10680

gaaccagcgc atggacagtt acgcgcacat gaacggctgg agcaacggca gctacagcat    10740

gatgcaggac cagctgggct acccgcagca cccgggcctc aatgcgcacg gcgcagcgca    10800

gatgcagccc atgcaccgct acgacgtgag cgccctgcag tacaactcca tgaccagctc    10860

gcagacctac atgaacggct cgcccaccta cagcatgtcc tactcgcagc agggcacccc    10920

tggcatggct cttggctcca tgggttcggt ggtcaagtcc gaggccagct ccagcccccc    10980

tgtggttacc tcttcctccc actccagggc gccctgccag gccggggacc tccgggacat    11040

gatcagcatg tatctccccg gcgccgaggt gccggaaccc gccgccccca gcagacttca    11100

catgtcccag cactaccaga gcggcccggt gcccggcacg gccattaacg gcacactgcc    11160

cctctcacac atgtgagcgg ccatcgatgt cgacaactaa cttaagctag caacggtttc    11220

cctctagcgg gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa    11280

taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat    11340

gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct    11400

ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct    11460

tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc    11520

gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa    11580

ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc    11640

gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg    11700

gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc    11760

ccgaaccacg gggacgtggt tttcctttga aaaacacgat aataccaatt cgccaccatg    11820

ggccccctca acgttagctt caccaacagg aactatgacc tcgactacga ctcggtgcag    11880

ccgtatttct actgcgacga ggaggagaac ttctaccagc agcagcagca gagcgagctg    11940

cagcccccgg cgcccagcga ggatatctgg aagaaattcg agctgctgcc caccccgccc    12000

ctgtccccta gccgccgctc cgggctctgc tcgccctcct acgttgcggt cacacccttc    12060

tcccttcggg gagacaacga cggcggtggc gggagcttct ccacggccga ccagctggag    12120

atggtgaccg agctgctggg aggagacatg gtgaaccaga gtttcatctg cgacccggac    12180

gacgagacct tcatcaaaaa catcatcatc caggactgta tgtggagcgg cttctcggcc    12240

gccgccaagc tcgtctcaga gaagctggcc tcctaccagg ctgcgcgcaa agacagcggc    12300

agcccgaacc ccgcccgcgg ccacagcgtc tgctccacct ccagcttgta cctgcaggat    12360

ctgagcgccg ccgcctcaga gtgcatcgac ccctcggtgg tcttccccta ccctctcaac    12420

gacagcagct cgcccaagtc ctgcgcctcg caagactcca gcgccttctc tccgtcctcg    12480

gattctctgc tctcctcgac ggagtcctcc ccgcagggca gccccgagcc cctggtgctc    12540

catgaggaga caccgcccac caccagcagc gactctgagg aggaacaaga agatgaggaa    12600

gaaatcgatg ttgtttctgt ggaaaagagg caggctcctg gcaaaaggtc agagtctgga    12660

tcaccttctg ctggaggcca cagcaaacct cctcacagcc cactggtcct caagaggtgc    12720

cacgtctcca cacatcagca caactacgca gcgcctccct ccactcggaa ggactatcct    12780

gctgccaaga gggtcaagtt ggacagtgtc agagtcctga gacagatcag caacaaccga    12840

aaatgcacca gccccaggtc ctcggacacc gaggagaatg tcaagaggcg aacacacaac    12900

gtcttggagc gccagaggag gaacgagcta aaacggagct tttttgccct gcgtgaccag    12960

atcccggagt tggaaaacaa tgaaaaggcc cccaaggtag ttatccttaa aaaagccaca    13020

gcatacatcc tgtccgtcca agcagaggag caaaagctca tttctgaaga ggacttgttg    13080

cggaaacgac gagaacagtt gaaacacaaa cttgaacagc tacggaactc ttgtgcgtaa    13140

tctagagtcg acccgggcgg ccgcaactaa cttaagctag caacggtttc cctctagcgg    13200

gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt    13260

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc    13320

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag    13380

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac    13440

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc    13500

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc    13560

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca    13620

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt    13680

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg    13740

gggacgtggt tttcctttga aaaacacgat aataccatga ccgagtacaa gcccacggtg    13800

cgcctcgcca cccgcgacga cgtccccagg gccgtacgca ccctcgccgc cgcgttcgcc    13860

gactaccccg ccacgcgcca caccgtcgat ccggaccgcc acatcgagcg ggtcaccgag    13920

ctgcaagaac tcttcctcac gcgcgtcggg ctcgacatcg gcaaggtgtg ggtcgcggac    13980

gacggcgccg cggtggcggt ctggaccacg ccggagagcg tcgaagcggg ggcggtgttc    14040

gccgagatcg gcccgcgcat ggccgagttg agcggttccc ggctggccgc gcagcaacag    14100

atggaaggcc tcctggcgcc gcaccggccc aaggagcccg cgtggttcct ggccaccgtc    14160

ggcgtctcgc ccgaccacca gggcaagggt ctgggcagcg ccgtcgtgct ccccggagtg    14220

gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga cctccgcgcc ccgcaacctc    14280

cccttctacg agcggctcgg cttcaccgtc accgccgacg tcgaggtgcc cgaaggaccg    14340

cgcacctggt gcatgacccg caagcccggt gcctgagaat tggcaagctg cttacataga    14400

actcgcggcg attggcatgc cgccttaaaa tttttatttt atttttcttt tcttttccga    14460

atcggatttt gtttttaata tttcaaaaaa aaaaaaaaaa aaaaaaaaaa cgcgtcgagg    14520

ggaattaatt cttgaagacg aaagggccag gtggcacttt tcggggaaat gtgcgcggaa    14580

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac    14640

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg    14700

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc    14760

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg    14820

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga    14880

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc gggcaagagc    14940

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag    15000

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga    15060

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg    15120

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga    15180

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt    15240

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact    15300

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt    15360

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg    15420

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta    15480

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac    15540

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta    15600

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt    15660

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt    15720

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt    15780

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc    15840

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg    15900

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg    15960

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt    16020

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac    16080

tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg agaaaggcgg    16140

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg    16200

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat    16260

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcgagctcga    16320

tttaggtgac actatag                                                   16337


<210>  30
<211>  16336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEE-Oct-Klf-Sox-cMyc-T7promoter

<400>  30
atgggcggcg catgagagaa gcccagacca attacctacc caaaatggag aaagttcacg       60

ttgacatcga ggaagacagc ccattcctca gagctttgca gcggagcttc ccgcagtttg      120

aggtagaagc caagcaggtc actgataatg accatgctaa tgccagagcg ttttcgcatc      180

tggcttcaaa actgatcgaa acggaggtgg acccatccga cacgatcctt gacattggaa      240

gtgcgcccgc ccgcagaatg tattctaagc acaagtatca ttgtatctgt ccgatgagat      300

gtgcggaaga tccggacaga ttgtataagt atgcaactaa gctgaagaaa aactgtaagg      360

aaataactga taaggaattg gacaagaaaa tgaaggagct ggccgccgtc atgagcgacc      420

ctgacctgga aactgagact atgtgcctcc acgacgacga gtcgtgtcgc tacgaagggc      480

aagtcgctgt ttaccaggat gtatacgcgg ttgacggacc gacaagtctc tatcaccaag      540

ccaataaggg agttagagtc gcctactgga taggctttga caccacccct tttatgttta      600

agaacttggc tggagcatat ccatcatact ctaccaactg ggccgacgaa accgtgttaa      660

cggctcgtaa cataggccta tgcagctctg acgttatgga gcggtcacgt agagggatgt      720

ccattcttag aaagaagtat ttgaaaccat ccaacaatgt tctattctct gttggctcga      780

ccatctacca cgagaagagg gacttactga ggagctggca cctgccgtct gtatttcact      840

tacgtggcaa gcaaaattac acatgtcggt gtgagactat agttagttgc gacgggtacg      900

tcgttaaaag aatagctatc agtccaggcc tgtatgggaa gccttcaggc tatgctgcta      960

cgatgcaccg cgagggattc ttgtgctgca aagtgacaga cacattgaac ggggagaggg     1020

tctcttttcc cgtgtgcacg tatgtgccag ctacattgtg tgaccaaatg actggcatac     1080

tggcaacaga tgtcagtgcg gacgacgcgc aaaaactgct ggttgggctc aaccagcgta     1140

tagtcgtcaa cggtcgcacc cagagaaaca ccaataccat gaaaaattac cttttgcccg     1200

tagtggccca ggcatttgct aggtgggcaa aggaatataa ggaagatcaa gaagatgaaa     1260

ggccactagg actacgagat agacagttag tcatggggtg ttgttgggct tttagaaggc     1320

acaagataac atctatttat aagcgcccgg atacccaaac catcatcaaa gtgaacagcg     1380

atttccactc attcgtgctg cccaggatag gcagtaacac attggagatc gggctgagaa     1440

caagaatcag gaaaatgtta gaggagcaca aggagccgtc acctctcatt accgccgagg     1500

acgtacaaga agctaagtgc gcagccgatg aggctaagga ggtgcgtgaa gccgaggagt     1560

tgcgcgcagc tctaccacct ttggcagctg atgttgagga gcccactctg gaagccgatg     1620

tcgacttgat gttacaagag gctggggccg gctcagtgga gacacctcgt ggcttgataa     1680

aggttaccag ctacgatggc gaggacaaga tcggctctta cgctgtgctt tctccgcagg     1740

ctgtactcaa gagtgaaaaa ttatcttgca tccaccctct cgctgaacaa gtcatagtga     1800

taacacactc tggccgaaaa gggcgttatg ccgtggaacc ataccatggt aaagtagtgg     1860

tgccagaggg acatgcaata cccgtccagg actttcaagc tctgagtgaa agtgccacca     1920

ttgtgtacaa cgaacgtgag ttcgtaaaca ggtacctgca ccatattgcc acacatggag     1980

gagcgctgaa cactgatgaa gaatattaca aaactgtcaa gcccagcgag cacgacggcg     2040

aatacctgta cgacatcgac aggaaacagt gcgtcaagaa agaactagtc actgggctag     2100

ggctcacagg cgagctggtg gatcctccct tccatgaatt cgcctacgag agtctgagaa     2160

cacgaccagc cgctccttac caagtaccaa ccataggggt gtatggcgtg ccaggatcag     2220

gcaagtctgg catcattaaa agcgcagtca ccaaaaaaga tctagtggtg agcgccaaga     2280

aagaaaactg tgcagaaatt ataagggacg tcaagaaaat gaaagggctg gacgtcaatg     2340

ccagaactgt ggactcagtg ctcttgaatg gatgcaaaca ccccgtagag accctgtata     2400

ttgacgaagc ttttgcttgt catgcaggta ctctcagagc gctcatagcc attataagac     2460

ctaaaaaggc agtgctctgc ggggatccca aacagtgcgg tttttttaac atgatgtgcc     2520

tgaaagtgca ttttaaccac gagatttgca cacaagtctt ccacaaaagc atctctcgcc     2580

gttgcactaa atctgtgact tcggtcgtct caaccttgtt ttacgacaaa aaaatgagaa     2640

cgacgaatcc gaaagagact aagattgtga ttgacactac cggcagtacc aaacctaagc     2700

aggacgatct cattctcact tgtttcagag ggtgggtgaa gcagttgcaa atagattaca     2760

aaggcaacga aataatgacg gcagctgcct ctcaagggct gacccgtaaa ggtgtgtatg     2820

ccgttcggta caaggtgaat gaaaatcctc tgtacgcacc cacctcagaa catgtgaacg     2880

tcctactgac ccgcacggag gaccgcatcg tgtggaaaac actagccggc gacccatgga     2940

taaaaacact gactgccaag taccctggga atttcactgc cacgatagag gagtggcaag     3000

cagagcatga tgccatcatg aggcacatct tggagagacc ggaccctacc gacgtcttcc     3060

agaataaggc aaacgtgtgt tgggccaagg ctttagtgcc ggtgctgaag accgctggca     3120

tagacatgac cactgaacaa tggaacactg tggattattt tgaaacggac aaagctcact     3180

cagcagagat agtattgaac caactatgcg tgaggttctt tggactcgat ctggactccg     3240

gtctattttc tgcacccact gttccgttat ccattaggaa taatcactgg gataactccc     3300

cgtcgcctaa catgtacggg ctgaataaag aagtggtccg tcagctctct cgcaggtacc     3360

cacaactgcc tcgggcagtt gccactggaa gagtctatga catgaacact ggtacactgc     3420

gcaattatga tccgcgcata aacctagtac ctgtaaacag aagactgcct catgctttag     3480

tcctccacca taatgaacac ccacagagtg acttttcttc attcgtcagc aaattgaagg     3540

gcagaactgt cctggtggtc ggggaaaagt tgtccgtccc aggcaaaatg gttgactggt     3600

tgtcagaccg gcctgaggct accttcagag ctcggctgga tttaggcatc ccaggtgatg     3660

tgcccaaata tgacataata tttgttaatg tgaggacccc atataaatac catcactatc     3720

agcagtgtga agaccatgcc attaagctta gcatgttgac caagaaagct tgtctgcatc     3780

tgaatcccgg cggaacctgt gtcagcatag gttatggtta cgctgacagg gccagcgaaa     3840

gcatcattgg tgctatagcg cggcagttca agttttcccg ggtatgcaaa ccgaaatcct     3900

cacttgaaga gacggaagtt ctgtttgtat tcattgggta cgatcgcaag gcccgtacgc     3960

acaattctta caagctttca tcaaccttga ccaacattta tacaggttcc agactccacg     4020

aagccggatg tgcaccctca tatcatgtgg tgcgagggga tattgccacg gccaccgaag     4080

gagtgattat aaatgctgct aacagcaaag gacaacctgg cggaggggtg tgcggagcgc     4140

tgtataagaa attcccggaa agcttcgatt tacagccgat cgaagtagga aaagcgcgac     4200

tggtcaaagg tgcagctaaa catatcattc atgccgtagg accaaacttc aacaaagttt     4260

cggaggttga aggtgacaaa cagttggcag aggcttatga gtccatcgct aagattgtca     4320

acgataacaa ttacaagtca gtagcgattc cactgttgtc caccggcatc ttttccggga     4380

acaaagatcg actaacccaa tcattgaacc atttgctgac agctttagac accactgatg     4440

cagatgtagc catatactgc agggacaaga aatgggaaat gactctcaag gaagcagtgg     4500

ctaggagaga agcagtggag gagatatgca tatccgacga ctcttcagtg acagaacctg     4560

atgcagagct ggtgagggtg catccgaaga gttctttggc tggaaggaag ggctacagca     4620

caagcgatgg caaaactttc tcatatttgg aagggaccaa gtttcaccag gcggccaagg     4680

atatagcaga aattaatgcc atgtggcccg ttgcaacgga ggccaatgag caggtatgca     4740

tgtatatcct cggagaaagc atgagcagta ttaggtcgaa atgccccgtc gaagagtcgg     4800

aagcctccac accacctagc acgctgcctt gcttgtgcat ccatgccatg actccagaaa     4860

gagtacagcg cctaaaagcc tcacgtccag aacaaattac tgtgtgctca tcctttccat     4920

tgccgaagta tagaatcact ggtgtgcaga agatccaatg ctcccagcct atattgttct     4980

caccgaaagt gcctgcgtat attcatccaa ggaagtatct cgtggaaaca ccaccggtag     5040

acgagactcc ggagccatcg gcagagaacc aatccacaga ggggacacct gaacaaccac     5100

cacttataac cgaggatgag accaggacta gaacgcctga gccgatcatc atcgaagagg     5160

aagaagagga tagcataagt ttgctgtcag atggcccgac ccaccaggtg ctgcaagtcg     5220

aggcagacat tcacgggccg ccctctgtat ctagctcatc ctggtccatt cctcatgcat     5280

ccgactttga tgtggacagt ttatccatac ttgacaccct ggagggagct agcgtgacca     5340

gcggggcaac gtcagccgag actaactctt acttcgcaaa gagtatggag tttctggcgc     5400

gaccggtgcc tgcgcctcga acagtattca ggaaccctcc acatcccgct ccgcgcacaa     5460

gaacaccgtc acttgcaccc agcagggcct gctcgagaac cagcctagtt tccaccccgc     5520

caggcgtgaa tagggtgatc actagagagg agctcgaggc gcttaccccg tcacgcactc     5580

ctagcaggtc ggtctcgaga accagcctgg tctccaaccc gccaggcgta aatagggtga     5640

ttacaagaga ggagtttgag gcgttcgtag cacaacaaca atgacggttt gatgcgggtg     5700

catacatctt ttcctccgac accggtcaag ggcatttaca acaaaaatca gtaaggcaaa     5760

cggtgctatc cgaagtggtg ttggagagga ccgaattgga gatttcgtat gccccgcgcc     5820

tcgaccaaga aaaagaagaa ttactacgca agaaattaca gttaaatccc acacctgcta     5880

acagaagcag ataccagtcc aggaaggtgg agaacatgaa agccataaca gctagacgta     5940

ttctgcaagg cctagggcat tatttgaagg cagaaggaaa agtggagtgc taccgaaccc     6000

tgcatcctgt tcctttgtat tcatctagtg tgaaccgtgc cttttcaagc cccaaggtcg     6060

cagtggaagc ctgtaacgcc atgttgaaag agaactttcc gactgtggct tcttactgta     6120

ttattccaga gtacgatgcc tatttggaca tggttgacgg agcttcatgc tgcttagaca     6180

ctgccagttt ttgccctgca aagctgcgca gctttccaaa gaaacactcc tatttggaac     6240

ccacaatacg atcggcagtg ccttcagcga tccagaacac gctccagaac gtcctggcag     6300

ctgccacaaa aagaaattgc aatgtcacgc aaatgagaga attgcccgta ttggattcgg     6360

cggcctttaa tgtggaatgc ttcaagaaat atgcgtgtaa taatgaatat tgggaaacgt     6420

ttaaagaaaa ccccatcagg cttactgaag aaaacgtggt aaattacatt accaaattaa     6480

aaggaccaaa agctgctgct ctttttgcga agacacataa tttgaatatg ttgcaggaca     6540

taccaatgga caggtttgta atggacttaa agagagacgt gaaagtgact ccaggaacaa     6600

aacatactga agaacggccc aaggtacagg tgatccaggc tgccgatccg ctagcaacag     6660

cgtatctgtg cggaatccac cgagagctgg ttaggagatt aaatgcggtc ctgcttccga     6720

acattcatac actgtttgat atgtcggctg aagactttga cgctattata gccgagcact     6780

tccagcctgg ggattgtgtt ctggaaactg acatcgcgtc gtttgataaa agtgaggacg     6840

acgccatggc tctgaccgcg ttaatgattc tggaagactt aggtgtggac gcagagctgt     6900

tgacgctgat tgaggcggct ttcggcgaaa tttcatcaat acatttgccc actaaaacta     6960

aatttaaatt cggagccatg atgaaatctg gaatgttcct cacactgttt gtgaacacag     7020

tcattaacat tgtaatcgca agcagagtgt tgagagaacg gctaaccgga tcaccatgtg     7080

cagcattcat tggagatgac aatatcgtga aaggagtcaa atcggacaaa ttaatggcag     7140

acaggtgcgc cacctggttg aatatggaag tcaagattat agatgctgtg gtgggcgaga     7200

aagcgcctta tttctgtgga gggtttattt tgtgtgactc cgtgaccggc acagcgtgcc     7260

gtgtggcaga ccccctaaaa aggctgttta agcttggcaa acctctggca gcagacgatg     7320

aacatgatga tgacaggaga agggcattgc atgaagagtc aacacgctgg aaccgagtgg     7380

gtattctttc agagctgtgc aaggcagtag aatcaaggta tgaaaccgta ggaacttcca     7440

tcatagttat ggccatgact actctagcta gcagtgttaa atcattcagc tacctgagag     7500

gggcccctat aactctctac ggctaacctg aatggactac gacatagtct agtccgccaa     7560

gtctagcata tgggcgcgtg aattcgccac catggcggga cacctggctt cggatttcgc     7620

cttctcgccc cctccaggtg gtggaggtga tgggccaggg gggccggagc cgggctgggt     7680

tgatcctcgg acctggctaa gcttccaagg ccctcctgga gggccaggaa tcgggccggg     7740

ggttgggcca ggctctgagg tgtgggggat tcccccatgc cccccgccgt atgagttctg     7800

tggggggatg gcgtactgtg ggccccaggt tggagtgggg ctagtgcccc aaggcggctt     7860

ggagacctct cagcctgagg gcgaagcagg agtcggggtg gagagcaact ccgatggggc     7920

ctccccggag ccctgcaccg tcacccctgg tgccgtgaag ctggagaagg agaagctgga     7980

gcaaaacccg gaggagtccc aggacatcaa agctctgcag aaagaactcg agcaatttgc     8040

caagctcctg aagcagaaga ggatcaccct gggatataca caggccgatg tggggctcac     8100

cctgggggtt ctatttggga aggtattcag ccaaacgacc atctgccgct ttgaggctct     8160

gcagcttagc ttcaagaaca tgtgtaagct gcggcccttg ctgcagaagt gggtggagga     8220

agctgacaac aatgaaaatc ttcaggagat atgcaaagca gaaaccctcg tgcaggcccg     8280

aaagagaaag cgaaccagta tcgagaaccg agtgagaggc aacctggaga atttgttcct     8340

gcagtgcccg aaacccacac tgcagcagat cagccacatc gcccagcagc ttgggctcga     8400

gaaggatgtg gtccgagtgt ggttctgtaa ccggcgccag aagggcaagc gatcaagcag     8460

cgactatgca caacgagagg attttgaggc tgctgggtct cctttctcag ggggaccagt     8520

gtcctttcct ctggccccag ggccccattt tggtacccca ggctatggga gccctcactt     8580

cactgcactg tactcctcgg tccctttccc tgagggggaa gcctttcccc ctgtctccgt     8640

caccactctg ggctctccca tgcattcaaa ctctagtgag ggcagaggaa gtctgctaac     8700

atgcggtgac gtcgaggaga atcctggccc acaattgatg gctgtcagcg acgcgctgct     8760

cccatctttc tccacgttcg cgtctggccc ggcgggaagg gagaagacac tgcgtcaagc     8820

aggtgccccg aataaccgct ggcgggagga gctctcccac atgaagcgac ttcccccagt     8880

gcttcccggc cgcccctatg acctggcggc ggcgaccgtg gccacagacc tggagagcgg     8940

cggagccggt gcggcttgcg gcggtagcaa cctggcgccc ctacctcgga gagagaccga     9000

ggagttcaac gatctcctgg acctggactt tattctctcc aattcgctga cccatcctcc     9060

ggagtcagtg gccgccaccg tgtcctcgtc agcgtcagcc tcctcttcgt cgtcgccgtc     9120

gagcagcggc cctgccagcg cgccctccac ctgcagcttc acctatccga tccgggccgg     9180

gaacgacccg ggcgtggcgc cgggcggcac gggcggaggc ctcctctatg gcagggagtc     9240

cgctccccct ccgacggctc ccttcaacct ggcggacatc aacgacgtga gcccctcggg     9300

cggcttcgtg gccgagctcc tgcggccaga attggacccg gtgtacattc cgccgcagca     9360

gccgcagccg ccaggtggcg ggctgatggg caagttcgtg ctgaaggcgt cgctgagcgc     9420

ccctggcagc gagtacggca gcccgtcggt catcagcgtc agcaaaggca gccctgacgg     9480

cagccacccg gtggtggtgg cgccctacaa cggcgggccg ccgcgcacgt gccccaagat     9540

caagcaggag gcggtctctt cgtgcaccca cttgggcgct ggaccccctc tcagcaatgg     9600

ccaccggccg gctgcacacg acttccccct ggggcggcag ctccccagca ggactacccc     9660

gaccctgggt cttgaggaag tgctgagcag cagggactgt caccctgccc tgccgcttcc     9720

tcccggcttc catccccacc cggggcccaa ttacccatcc ttcctgcccg atcagatgca     9780

gccgcaagtc ccgccgctcc attaccaaga gctcatgcca cccggttcct gcatgccaga     9840

ggagcccaag ccaaagaggg gaagacgatc gtggccccgg aaaaggaccg ccacccacac     9900

ttgtgattac gcgggctgcg gcaaaaccta cacaaagagt tcccatctca aggcacacct     9960

gcgaacccac acaggtgaga aaccttacca ctgtgactgg gacggctgtg gatggaaatt    10020

cgcccgctca gatgaactga ccaggcacta ccgtaaacac acggggcacc gcccgttcca    10080

gtgccaaaaa tgcgaccgag cattttccag gtcggaccac ctcgccttac acatgaagag    10140

gcatttttct agacaatgta ctaactacgc tttgttgaaa ctcgctggcg atgttgaaag    10200

taaccccggt cctggcgcgc ccatgtacaa catgatggag acggagctga agccgccggg    10260

cccgcagcaa acttcggggg gcggcggcgg caactccacc gcggcggcgg ccggcggcaa    10320

ccagaaaaac agcccggacc gcgtcaagcg gcccatgaat gccttcatgg tgtggtcccg    10380

cgggcagcgg cgcaagatgg cccaggagaa ccccaagatg cacaactcgg agatcagcaa    10440

gcgcctgggc gccgagtgga aacttttgtc ggagacggag aagcggccgt tcatcgacga    10500

ggctaagcgg ctgcgagcgc tgcacatgaa ggagcacccg gattataaat accggccccg    10560

gcggaaaacc aagacgctca tgaagaagga taagtacacg ctgcccggcg ggctgctggc    10620

ccccggcggc aatagcatgg cgagcggggt cggggtgggc gccggcctgg gcgcgggcgt    10680

gaaccagcgc atggacagtt acgcgcacat gaacggctgg agcaacggca gctacagcat    10740

gatgcaggac cagctgggct acccgcagca cccgggcctc aatgcgcacg gcgcagcgca    10800

gatgcagccc atgcaccgct acgacgtgag cgccctgcag tacaactcca tgaccagctc    10860

gcagacctac atgaacggct cgcccaccta cagcatgtcc tactcgcagc agggcacccc    10920

tggcatggct cttggctcca tgggttcggt ggtcaagtcc gaggccagct ccagcccccc    10980

tgtggttacc tcttcctccc actccagggc gccctgccag gccggggacc tccgggacat    11040

gatcagcatg tatctccccg gcgccgaggt gccggaaccc gccgccccca gcagacttca    11100

catgtcccag cactaccaga gcggcccggt gcccggcacg gccattaacg gcacactgcc    11160

cctctcacac atgtgagcgg ccatcgatgt cgacaactaa cttaagctag caacggtttc    11220

cctctagcgg gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa    11280

taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat    11340

gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct    11400

ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct    11460

tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc    11520

gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa    11580

ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc    11640

gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg    11700

gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc    11760

ccgaaccacg gggacgtggt tttcctttga aaaacacgat aataccaatt cgccaccatg    11820

ggccccctca acgttagctt caccaacagg aactatgacc tcgactacga ctcggtgcag    11880

ccgtatttct actgcgacga ggaggagaac ttctaccagc agcagcagca gagcgagctg    11940

cagcccccgg cgcccagcga ggatatctgg aagaaattcg agctgctgcc caccccgccc    12000

ctgtccccta gccgccgctc cgggctctgc tcgccctcct acgttgcggt cacacccttc    12060

tcccttcggg gagacaacga cggcggtggc gggagcttct ccacggccga ccagctggag    12120

atggtgaccg agctgctggg aggagacatg gtgaaccaga gtttcatctg cgacccggac    12180

gacgagacct tcatcaaaaa catcatcatc caggactgta tgtggagcgg cttctcggcc    12240

gccgccaagc tcgtctcaga gaagctggcc tcctaccagg ctgcgcgcaa agacagcggc    12300

agcccgaacc ccgcccgcgg ccacagcgtc tgctccacct ccagcttgta cctgcaggat    12360

ctgagcgccg ccgcctcaga gtgcatcgac ccctcggtgg tcttccccta ccctctcaac    12420

gacagcagct cgcccaagtc ctgcgcctcg caagactcca gcgccttctc tccgtcctcg    12480

gattctctgc tctcctcgac ggagtcctcc ccgcagggca gccccgagcc cctggtgctc    12540

catgaggaga caccgcccac caccagcagc gactctgagg aggaacaaga agatgaggaa    12600

gaaatcgatg ttgtttctgt ggaaaagagg caggctcctg gcaaaaggtc agagtctgga    12660

tcaccttctg ctggaggcca cagcaaacct cctcacagcc cactggtcct caagaggtgc    12720

cacgtctcca cacatcagca caactacgca gcgcctccct ccactcggaa ggactatcct    12780

gctgccaaga gggtcaagtt ggacagtgtc agagtcctga gacagatcag caacaaccga    12840

aaatgcacca gccccaggtc ctcggacacc gaggagaatg tcaagaggcg aacacacaac    12900

gtcttggagc gccagaggag gaacgagcta aaacggagct tttttgccct gcgtgaccag    12960

atcccggagt tggaaaacaa tgaaaaggcc cccaaggtag ttatccttaa aaaagccaca    13020

gcatacatcc tgtccgtcca agcagaggag caaaagctca tttctgaaga ggacttgttg    13080

cggaaacgac gagaacagtt gaaacacaaa cttgaacagc tacggaactc ttgtgcgtaa    13140

tctagagtcg acccgggcgg ccgcaactaa cttaagctag caacggtttc cctctagcgg    13200

gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt    13260

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc    13320

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag    13380

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac    13440

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc    13500

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc    13560

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca    13620

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt    13680

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg    13740

gggacgtggt tttcctttga aaaacacgat aataccatga ccgagtacaa gcccacggtg    13800

cgcctcgcca cccgcgacga cgtccccagg gccgtacgca ccctcgccgc cgcgttcgcc    13860

gactaccccg ccacgcgcca caccgtcgat ccggaccgcc acatcgagcg ggtcaccgag    13920

ctgcaagaac tcttcctcac gcgcgtcggg ctcgacatcg gcaaggtgtg ggtcgcggac    13980

gacggcgccg cggtggcggt ctggaccacg ccggagagcg tcgaagcggg ggcggtgttc    14040

gccgagatcg gcccgcgcat ggccgagttg agcggttccc ggctggccgc gcagcaacag    14100

atggaaggcc tcctggcgcc gcaccggccc aaggagcccg cgtggttcct ggccaccgtc    14160

ggcgtctcgc ccgaccacca gggcaagggt ctgggcagcg ccgtcgtgct ccccggagtg    14220

gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga cctccgcgcc ccgcaacctc    14280

cccttctacg agcggctcgg cttcaccgtc accgccgacg tcgaggtgcc cgaaggaccg    14340

cgcacctggt gcatgacccg caagcccggt gcctgagaat tggcaagctg cttacataga    14400

actcgcggcg attggcatgc cgccttaaaa tttttatttt atttttcttt tcttttccga    14460

atcggatttt gtttttaata tttcaaaaaa aaaaaaaaaa aaaaaaaaaa cgcgtcgagg    14520

ggaattaatt cttgaagacg aaagggccag gtggcacttt tcggggaaat gtgcgcggaa    14580

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac    14640

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg    14700

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc    14760

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg    14820

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga    14880

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc gggcaagagc    14940

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag    15000

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga    15060

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg    15120

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga    15180

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt    15240

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact    15300

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt    15360

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg    15420

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta    15480

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac    15540

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta    15600

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt    15660

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt    15720

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt    15780

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc    15840

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg    15900

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg    15960

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt    16020

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac    16080

tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg agaaaggcgg    16140

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg    16200

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat    16260

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcgagctcta    16320

atacgactca ctatag                                                    16336


<210>  31
<211>  16861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEE-Oct-Klf-Sox-Glis-SP6

<400>  31
atgggcggcg catgagagaa gcccagacca attacctacc caaaatggag aaagttcacg       60

ttgacatcga ggaagacagc ccattcctca gagctttgca gcggagcttc ccgcagtttg      120

aggtagaagc caagcaggtc actgataatg accatgctaa tgccagagcg ttttcgcatc      180

tggcttcaaa actgatcgaa acggaggtgg acccatccga cacgatcctt gacattggaa      240

gtgcgcccgc ccgcagaatg tattctaagc acaagtatca ttgtatctgt ccgatgagat      300

gtgcggaaga tccggacaga ttgtataagt atgcaactaa gctgaagaaa aactgtaagg      360

aaataactga taaggaattg gacaagaaaa tgaaggagct ggccgccgtc atgagcgacc      420

ctgacctgga aactgagact atgtgcctcc acgacgacga gtcgtgtcgc tacgaagggc      480

aagtcgctgt ttaccaggat gtatacgcgg ttgacggacc gacaagtctc tatcaccaag      540

ccaataaggg agttagagtc gcctactgga taggctttga caccacccct tttatgttta      600

agaacttggc tggagcatat ccatcatact ctaccaactg ggccgacgaa accgtgttaa      660

cggctcgtaa cataggccta tgcagctctg acgttatgga gcggtcacgt agagggatgt      720

ccattcttag aaagaagtat ttgaaaccat ccaacaatgt tctattctct gttggctcga      780

ccatctacca cgagaagagg gacttactga ggagctggca cctgccgtct gtatttcact      840

tacgtggcaa gcaaaattac acatgtcggt gtgagactat agttagttgc gacgggtacg      900

tcgttaaaag aatagctatc agtccaggcc tgtatgggaa gccttcaggc tatgctgcta      960

cgatgcaccg cgagggattc ttgtgctgca aagtgacaga cacattgaac ggggagaggg     1020

tctcttttcc cgtgtgcacg tatgtgccag ctacattgtg tgaccaaatg actggcatac     1080

tggcaacaga tgtcagtgcg gacgacgcgc aaaaactgct ggttgggctc aaccagcgta     1140

tagtcgtcaa cggtcgcacc cagagaaaca ccaataccat gaaaaattac cttttgcccg     1200

tagtggccca ggcatttgct aggtgggcaa aggaatataa ggaagatcaa gaagatgaaa     1260

ggccactagg actacgagat agacagttag tcatggggtg ttgttgggct tttagaaggc     1320

acaagataac atctatttat aagcgcccgg atacccaaac catcatcaaa gtgaacagcg     1380

atttccactc attcgtgctg cccaggatag gcagtaacac attggagatc gggctgagaa     1440

caagaatcag gaaaatgtta gaggagcaca aggagccgtc acctctcatt accgccgagg     1500

acgtacaaga agctaagtgc gcagccgatg aggctaagga ggtgcgtgaa gccgaggagt     1560

tgcgcgcagc tctaccacct ttggcagctg atgttgagga gcccactctg gaagccgatg     1620

tcgacttgat gttacaagag gctggggccg gctcagtgga gacacctcgt ggcttgataa     1680

aggttaccag ctacgatggc gaggacaaga tcggctctta cgctgtgctt tctccgcagg     1740

ctgtactcaa gagtgaaaaa ttatcttgca tccaccctct cgctgaacaa gtcatagtga     1800

taacacactc tggccgaaaa gggcgttatg ccgtggaacc ataccatggt aaagtagtgg     1860

tgccagaggg acatgcaata cccgtccagg actttcaagc tctgagtgaa agtgccacca     1920

ttgtgtacaa cgaacgtgag ttcgtaaaca ggtacctgca ccatattgcc acacatggag     1980

gagcgctgaa cactgatgaa gaatattaca aaactgtcaa gcccagcgag cacgacggcg     2040

aatacctgta cgacatcgac aggaaacagt gcgtcaagaa agaactagtc actgggctag     2100

ggctcacagg cgagctggtg gatcctccct tccatgaatt cgcctacgag agtctgagaa     2160

cacgaccagc cgctccttac caagtaccaa ccataggggt gtatggcgtg ccaggatcag     2220

gcaagtctgg catcattaaa agcgcagtca ccaaaaaaga tctagtggtg agcgccaaga     2280

aagaaaactg tgcagaaatt ataagggacg tcaagaaaat gaaagggctg gacgtcaatg     2340

ccagaactgt ggactcagtg ctcttgaatg gatgcaaaca ccccgtagag accctgtata     2400

ttgacgaagc ttttgcttgt catgcaggta ctctcagagc gctcatagcc attataagac     2460

ctaaaaaggc agtgctctgc ggggatccca aacagtgcgg tttttttaac atgatgtgcc     2520

tgaaagtgca ttttaaccac gagatttgca cacaagtctt ccacaaaagc atctctcgcc     2580

gttgcactaa atctgtgact tcggtcgtct caaccttgtt ttacgacaaa aaaatgagaa     2640

cgacgaatcc gaaagagact aagattgtga ttgacactac cggcagtacc aaacctaagc     2700

aggacgatct cattctcact tgtttcagag ggtgggtgaa gcagttgcaa atagattaca     2760

aaggcaacga aataatgacg gcagctgcct ctcaagggct gacccgtaaa ggtgtgtatg     2820

ccgttcggta caaggtgaat gaaaatcctc tgtacgcacc cacctcagaa catgtgaacg     2880

tcctactgac ccgcacggag gaccgcatcg tgtggaaaac actagccggc gacccatgga     2940

taaaaacact gactgccaag taccctggga atttcactgc cacgatagag gagtggcaag     3000

cagagcatga tgccatcatg aggcacatct tggagagacc ggaccctacc gacgtcttcc     3060

agaataaggc aaacgtgtgt tgggccaagg ctttagtgcc ggtgctgaag accgctggca     3120

tagacatgac cactgaacaa tggaacactg tggattattt tgaaacggac aaagctcact     3180

cagcagagat agtattgaac caactatgcg tgaggttctt tggactcgat ctggactccg     3240

gtctattttc tgcacccact gttccgttat ccattaggaa taatcactgg gataactccc     3300

cgtcgcctaa catgtacggg ctgaataaag aagtggtccg tcagctctct cgcaggtacc     3360

cacaactgcc tcgggcagtt gccactggaa gagtctatga catgaacact ggtacactgc     3420

gcaattatga tccgcgcata aacctagtac ctgtaaacag aagactgcct catgctttag     3480

tcctccacca taatgaacac ccacagagtg acttttcttc attcgtcagc aaattgaagg     3540

gcagaactgt cctggtggtc ggggaaaagt tgtccgtccc aggcaaaatg gttgactggt     3600

tgtcagaccg gcctgaggct accttcagag ctcggctgga tttaggcatc ccaggtgatg     3660

tgcccaaata tgacataata tttgttaatg tgaggacccc atataaatac catcactatc     3720

agcagtgtga agaccatgcc attaagctta gcatgttgac caagaaagct tgtctgcatc     3780

tgaatcccgg cggaacctgt gtcagcatag gttatggtta cgctgacagg gccagcgaaa     3840

gcatcattgg tgctatagcg cggcagttca agttttcccg ggtatgcaaa ccgaaatcct     3900

cacttgaaga gacggaagtt ctgtttgtat tcattgggta cgatcgcaag gcccgtacgc     3960

acaattctta caagctttca tcaaccttga ccaacattta tacaggttcc agactccacg     4020

aagccggatg tgcaccctca tatcatgtgg tgcgagggga tattgccacg gccaccgaag     4080

gagtgattat aaatgctgct aacagcaaag gacaacctgg cggaggggtg tgcggagcgc     4140

tgtataagaa attcccggaa agcttcgatt tacagccgat cgaagtagga aaagcgcgac     4200

tggtcaaagg tgcagctaaa catatcattc atgccgtagg accaaacttc aacaaagttt     4260

cggaggttga aggtgacaaa cagttggcag aggcttatga gtccatcgct aagattgtca     4320

acgataacaa ttacaagtca gtagcgattc cactgttgtc caccggcatc ttttccggga     4380

acaaagatcg actaacccaa tcattgaacc atttgctgac agctttagac accactgatg     4440

cagatgtagc catatactgc agggacaaga aatgggaaat gactctcaag gaagcagtgg     4500

ctaggagaga agcagtggag gagatatgca tatccgacga ctcttcagtg acagaacctg     4560

atgcagagct ggtgagggtg catccgaaga gttctttggc tggaaggaag ggctacagca     4620

caagcgatgg caaaactttc tcatatttgg aagggaccaa gtttcaccag gcggccaagg     4680

atatagcaga aattaatgcc atgtggcccg ttgcaacgga ggccaatgag caggtatgca     4740

tgtatatcct cggagaaagc atgagcagta ttaggtcgaa atgccccgtc gaagagtcgg     4800

aagcctccac accacctagc acgctgcctt gcttgtgcat ccatgccatg actccagaaa     4860

gagtacagcg cctaaaagcc tcacgtccag aacaaattac tgtgtgctca tcctttccat     4920

tgccgaagta tagaatcact ggtgtgcaga agatccaatg ctcccagcct atattgttct     4980

caccgaaagt gcctgcgtat attcatccaa ggaagtatct cgtggaaaca ccaccggtag     5040

acgagactcc ggagccatcg gcagagaacc aatccacaga ggggacacct gaacaaccac     5100

cacttataac cgaggatgag accaggacta gaacgcctga gccgatcatc atcgaagagg     5160

aagaagagga tagcataagt ttgctgtcag atggcccgac ccaccaggtg ctgcaagtcg     5220

aggcagacat tcacgggccg ccctctgtat ctagctcatc ctggtccatt cctcatgcat     5280

ccgactttga tgtggacagt ttatccatac ttgacaccct ggagggagct agcgtgacca     5340

gcggggcaac gtcagccgag actaactctt acttcgcaaa gagtatggag tttctggcgc     5400

gaccggtgcc tgcgcctcga acagtattca ggaaccctcc acatcccgct ccgcgcacaa     5460

gaacaccgtc acttgcaccc agcagggcct gctcgagaac cagcctagtt tccaccccgc     5520

caggcgtgaa tagggtgatc actagagagg agctcgaggc gcttaccccg tcacgcactc     5580

ctagcaggtc ggtctcgaga accagcctgg tctccaaccc gccaggcgta aatagggtga     5640

ttacaagaga ggagtttgag gcgttcgtag cacaacaaca atgacggttt gatgcgggtg     5700

catacatctt ttcctccgac accggtcaag ggcatttaca acaaaaatca gtaaggcaaa     5760

cggtgctatc cgaagtggtg ttggagagga ccgaattgga gatttcgtat gccccgcgcc     5820

tcgaccaaga aaaagaagaa ttactacgca agaaattaca gttaaatccc acacctgcta     5880

acagaagcag ataccagtcc aggaaggtgg agaacatgaa agccataaca gctagacgta     5940

ttctgcaagg cctagggcat tatttgaagg cagaaggaaa agtggagtgc taccgaaccc     6000

tgcatcctgt tcctttgtat tcatctagtg tgaaccgtgc cttttcaagc cccaaggtcg     6060

cagtggaagc ctgtaacgcc atgttgaaag agaactttcc gactgtggct tcttactgta     6120

ttattccaga gtacgatgcc tatttggaca tggttgacgg agcttcatgc tgcttagaca     6180

ctgccagttt ttgccctgca aagctgcgca gctttccaaa gaaacactcc tatttggaac     6240

ccacaatacg atcggcagtg ccttcagcga tccagaacac gctccagaac gtcctggcag     6300

ctgccacaaa aagaaattgc aatgtcacgc aaatgagaga attgcccgta ttggattcgg     6360

cggcctttaa tgtggaatgc ttcaagaaat atgcgtgtaa taatgaatat tgggaaacgt     6420

ttaaagaaaa ccccatcagg cttactgaag aaaacgtggt aaattacatt accaaattaa     6480

aaggaccaaa agctgctgct ctttttgcga agacacataa tttgaatatg ttgcaggaca     6540

taccaatgga caggtttgta atggacttaa agagagacgt gaaagtgact ccaggaacaa     6600

aacatactga agaacggccc aaggtacagg tgatccaggc tgccgatccg ctagcaacag     6660

cgtatctgtg cggaatccac cgagagctgg ttaggagatt aaatgcggtc ctgcttccga     6720

acattcatac actgtttgat atgtcggctg aagactttga cgctattata gccgagcact     6780

tccagcctgg ggattgtgtt ctggaaactg acatcgcgtc gtttgataaa agtgaggacg     6840

acgccatggc tctgaccgcg ttaatgattc tggaagactt aggtgtggac gcagagctgt     6900

tgacgctgat tgaggcggct ttcggcgaaa tttcatcaat acatttgccc actaaaacta     6960

aatttaaatt cggagccatg atgaaatctg gaatgttcct cacactgttt gtgaacacag     7020

tcattaacat tgtaatcgca agcagagtgt tgagagaacg gctaaccgga tcaccatgtg     7080

cagcattcat tggagatgac aatatcgtga aaggagtcaa atcggacaaa ttaatggcag     7140

acaggtgcgc cacctggttg aatatggaag tcaagattat agatgctgtg gtgggcgaga     7200

aagcgcctta tttctgtgga gggtttattt tgtgtgactc cgtgaccggc acagcgtgcc     7260

gtgtggcaga ccccctaaaa aggctgttta agcttggcaa acctctggca gcagacgatg     7320

aacatgatga tgacaggaga agggcattgc atgaagagtc aacacgctgg aaccgagtgg     7380

gtattctttc agagctgtgc aaggcagtag aatcaaggta tgaaaccgta ggaacttcca     7440

tcatagttat ggccatgact actctagcta gcagtgttaa atcattcagc tacctgagag     7500

gggcccctat aactctctac ggctaacctg aatggactac gacatagtct agtccgccaa     7560

gtctagcata tgggcgcgtg aattcgccac catggcggga cacctggctt cggatttcgc     7620

cttctcgccc cctccaggtg gtggaggtga tgggccaggg gggccggagc cgggctgggt     7680

tgatcctcgg acctggctaa gcttccaagg ccctcctgga gggccaggaa tcgggccggg     7740

ggttgggcca ggctctgagg tgtgggggat tcccccatgc cccccgccgt atgagttctg     7800

tggggggatg gcgtactgtg ggccccaggt tggagtgggg ctagtgcccc aaggcggctt     7860

ggagacctct cagcctgagg gcgaagcagg agtcggggtg gagagcaact ccgatggggc     7920

ctccccggag ccctgcaccg tcacccctgg tgccgtgaag ctggagaagg agaagctgga     7980

gcaaaacccg gaggagtccc aggacatcaa agctctgcag aaagaactcg agcaatttgc     8040

caagctcctg aagcagaaga ggatcaccct gggatataca caggccgatg tggggctcac     8100

cctgggggtt ctatttggga aggtattcag ccaaacgacc atctgccgct ttgaggctct     8160

gcagcttagc ttcaagaaca tgtgtaagct gcggcccttg ctgcagaagt gggtggagga     8220

agctgacaac aatgaaaatc ttcaggagat atgcaaagca gaaaccctcg tgcaggcccg     8280

aaagagaaag cgaaccagta tcgagaaccg agtgagaggc aacctggaga atttgttcct     8340

gcagtgcccg aaacccacac tgcagcagat cagccacatc gcccagcagc ttgggctcga     8400

gaaggatgtg gtccgagtgt ggttctgtaa ccggcgccag aagggcaagc gatcaagcag     8460

cgactatgca caacgagagg attttgaggc tgctgggtct cctttctcag ggggaccagt     8520

gtcctttcct ctggccccag ggccccattt tggtacccca ggctatggga gccctcactt     8580

cactgcactg tactcctcgg tccctttccc tgagggggaa gcctttcccc ctgtctccgt     8640

caccactctg ggctctccca tgcattcaaa ctctagtgag ggcagaggaa gtctgctaac     8700

atgcggtgac gtcgaggaga atcctggccc acaattgatg gctgtcagcg acgcgctgct     8760

cccatctttc tccacgttcg cgtctggccc ggcgggaagg gagaagacac tgcgtcaagc     8820

aggtgccccg aataaccgct ggcgggagga gctctcccac atgaagcgac ttcccccagt     8880

gcttcccggc cgcccctatg acctggcggc ggcgaccgtg gccacagacc tggagagcgg     8940

cggagccggt gcggcttgcg gcggtagcaa cctggcgccc ctacctcgga gagagaccga     9000

ggagttcaac gatctcctgg acctggactt tattctctcc aattcgctga cccatcctcc     9060

ggagtcagtg gccgccaccg tgtcctcgtc agcgtcagcc tcctcttcgt cgtcgccgtc     9120

gagcagcggc cctgccagcg cgccctccac ctgcagcttc acctatccga tccgggccgg     9180

gaacgacccg ggcgtggcgc cgggcggcac gggcggaggc ctcctctatg gcagggagtc     9240

cgctccccct ccgacggctc ccttcaacct ggcggacatc aacgacgtga gcccctcggg     9300

cggcttcgtg gccgagctcc tgcggccaga attggacccg gtgtacattc cgccgcagca     9360

gccgcagccg ccaggtggcg ggctgatggg caagttcgtg ctgaaggcgt cgctgagcgc     9420

ccctggcagc gagtacggca gcccgtcggt catcagcgtc agcaaaggca gccctgacgg     9480

cagccacccg gtggtggtgg cgccctacaa cggcgggccg ccgcgcacgt gccccaagat     9540

caagcaggag gcggtctctt cgtgcaccca cttgggcgct ggaccccctc tcagcaatgg     9600

ccaccggccg gctgcacacg acttccccct ggggcggcag ctccccagca ggactacccc     9660

gaccctgggt cttgaggaag tgctgagcag cagggactgt caccctgccc tgccgcttcc     9720

tcccggcttc catccccacc cggggcccaa ttacccatcc ttcctgcccg atcagatgca     9780

gccgcaagtc ccgccgctcc attaccaaga gctcatgcca cccggttcct gcatgccaga     9840

ggagcccaag ccaaagaggg gaagacgatc gtggccccgg aaaaggaccg ccacccacac     9900

ttgtgattac gcgggctgcg gcaaaaccta cacaaagagt tcccatctca aggcacacct     9960

gcgaacccac acaggtgaga aaccttacca ctgtgactgg gacggctgtg gatggaaatt    10020

cgcccgctca gatgaactga ccaggcacta ccgtaaacac acggggcacc gcccgttcca    10080

gtgccaaaaa tgcgaccgag cattttccag gtcggaccac ctcgccttac acatgaagag    10140

gcatttttct agacaatgta ctaactacgc tttgttgaaa ctcgctggcg atgttgaaag    10200

taaccccggt cctggcgcgc ccatgtacaa catgatggag acggagctga agccgccggg    10260

cccgcagcaa acttcggggg gcggcggcgg caactccacc gcggcggcgg ccggcggcaa    10320

ccagaaaaac agcccggacc gcgtcaagcg gcccatgaat gccttcatgg tgtggtcccg    10380

cgggcagcgg cgcaagatgg cccaggagaa ccccaagatg cacaactcgg agatcagcaa    10440

gcgcctgggc gccgagtgga aacttttgtc ggagacggag aagcggccgt tcatcgacga    10500

ggctaagcgg ctgcgagcgc tgcacatgaa ggagcacccg gattataaat accggccccg    10560

gcggaaaacc aagacgctca tgaagaagga taagtacacg ctgcccggcg ggctgctggc    10620

ccccggcggc aatagcatgg cgagcggggt cggggtgggc gccggcctgg gcgcgggcgt    10680

gaaccagcgc atggacagtt acgcgcacat gaacggctgg agcaacggca gctacagcat    10740

gatgcaggac cagctgggct acccgcagca cccgggcctc aatgcgcacg gcgcagcgca    10800

gatgcagccc atgcaccgct acgacgtgag cgccctgcag tacaactcca tgaccagctc    10860

gcagacctac atgaacggct cgcccaccta cagcatgtcc tactcgcagc agggcacccc    10920

tggcatggct cttggctcca tgggttcggt ggtcaagtcc gaggccagct ccagcccccc    10980

tgtggttacc tcttcctccc actccagggc gccctgccag gccggggacc tccgggacat    11040

gatcagcatg tatctccccg gcgccgaggt gccggaaccc gccgccccca gcagacttca    11100

catgtcccag cactaccaga gcggcccggt gcccggcacg gccattaacg gcacactgcc    11160

cctctcacac atgtgagcgg ccatcgatgt cgacaactaa cttaagctag caacggtttc    11220

cctctagcgg gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa    11280

taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat    11340

gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct    11400

ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct    11460

tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc    11520

gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa    11580

ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc    11640

gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg    11700

gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc    11760

ccgaaccacg gggacgtggt tttcctttga aaaacacgat aataccaatt cgccaccatg    11820

gcagaggccc gcacatccct gtctgcccac tgtcggggcc cgctggccac tggcctgcac    11880

ccagacctgg acctcccggg ccgaagcctc gccacccctg cgccttcctg ctaccttctg    11940

ggcagcgaac ccagctctgg cctgggcctc cagcccgaga cccacctccc cgagggcagc    12000

ctgaagcggt gctgcgtctt gggcctaccc cccacctccc cagcctcctc ctcaccctgt    12060

gcctcctccg acgtcacctc catcatccgc tcctcccaga cgtctctggt cacctgtgta    12120

aatggactcc ggagcccccc tctgacggga gatctggggg gcccttccaa gcgggcccgg    12180

cctggccctg catcgacgga cagccatgag ggcagcttgc aacttgaagc ctgccggaag    12240

gcgagcttcc tgaagcagga acccgcggat gagttttcag agctctttgg gcctcaccag    12300

cagggcctgc cgccccccta tcccctgtct cagttgccgc ctggcccaag ccttggaggc    12360

ctggggctgg gcctggcagg cagggtggtg gccgggcggc aggcgtgccg ctgggtggac    12420

tgctgtgcag cctatgagca gcaggaggag ctggtgcggc acatcgagaa gagccacatc    12480

gaccagcgca agggcgagga cttcacctgc ttctgggctg gctgcgtgcg ccgctacaag    12540

cccttcaacg cccgctacaa gctgctcatc cacatgcgag tgcactcggg cgagaagccc    12600

aacaagtgca tgtttgaagg ctgcagcaag gccttctcac ggctggagaa cctcaagatc    12660

cacctgagga gccacacggg cgagaagccg tacctgtgcc agcacccggg ttgccagaag    12720

gccttcagca actccagcga ccgcgccaag caccagcgca cccacctaga cacgaagccg    12780

tacgcctgtc agatccctgg ctgctccaag cgctacacag accccagctc cctccgcaag    12840

cacgtcaagg cccattcagc caaagagcag caggtgcgta agaagctgca tgcgggccct    12900

gacaccgagg ccgacgtcct gaccgagtgt ctggtcctgc agcagctcca cacgtccaca    12960

cagctggctg ccagcgacgg caagggtggc tgtggcctgg gccaggagct gctcccaggt    13020

gtgtatcctg gctccatcac cccccataac ggacttgcat cgggcctcct gcccccagcg    13080

cacgacgtac cttccaggca ccacccgctg gatgccacca ccagttccca ccaccatctg    13140

tcccctctgc ccatggctga gagcacccgg gatgggttgg ggcccggcct cctctcacca    13200

atagtcagcc ccctgaaggg gctggggcca ccgccgctgc ccccatcctc tcagagccat    13260

tctccggggg gccagccctt ccccacactc cccagcaagc cgtcctaccc acccttccag    13320

agccctccac ccccgcctct gcccagccca caaggttacc agggcagttt ccactccatc    13380

cagagttgct tcccctatgg cgactgctac cggatggctg aaccagcagc cggtggggac    13440

ggactggtcg gggagaccca cggtttcaac cccctgcggc ccaatggcta ccacagcctc    13500

agcacgccct tgcctgccac aggctatgag gccctggctg aggcctcatg ccccacagcg    13560

ctgccacagc agccatctga agatgtggtg tccagcggcc ccgaggactg tggcttcttc    13620

cccaatggag cctttgacca ctgcctgggc cacatcccct ccatctacac agacacctga    13680

gcggccgcaa ctaacttaag ctagcaacgg tttccctcta gcgggatcaa ttccgccccc    13740

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat    13800

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt    13860

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt    13920

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc    13980

gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc    14040

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat    14100

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc    14160

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg    14220

tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct    14280

ttgaaaaaca cgataatacc atgaccgagt acaagcccac ggtgcgcctc gccacccgcg    14340

acgacgtccc cagggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc    14400

gccacaccgt cgatccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc    14460

tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg    14520

cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc    14580

gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg    14640

cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc    14700

accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg    14760

ccggggtgcc cgccttcctg gagacctccg cgccccgcaa cctccccttc tacgagcggc    14820

tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga    14880

cccgcaagcc cggtgcctga gaattggcaa gctgcttaca tagaactcgc ggcgattggc    14940

atgccgcctt aaaattttta ttttattttt cttttctttt ccgaatcgga ttttgttttt    15000

aatatttcaa aaaaaaaaaa aaaaaaaaaa aaaacgcgtc gaggggaatt aattcttgaa    15060

gacgaaaggg ccaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt    15120

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca    15180

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt    15240

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga    15300

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa    15360

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct    15420

gctatgtggc gcggtattat cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat    15480

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga    15540

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc    15600

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat    15660

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa    15720

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac    15780

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa    15840

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc    15900

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc    15960

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag    16020

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta    16080

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa    16140

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc    16200

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat    16260

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga    16320

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt    16380

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata    16440

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac    16500

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg    16560

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg    16620

tgagcattga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag    16680

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct    16740

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc    16800

aggggggcgg agcctatgga aaaacgccag caacgcgagc tcgatttagg tgacactata    16860

g                                                                    16861


<210>  32
<211>  16860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEE-Oct-Klf-Sox-Glis-T7

<400>  32
atgggcggcg catgagagaa gcccagacca attacctacc caaaatggag aaagttcacg       60

ttgacatcga ggaagacagc ccattcctca gagctttgca gcggagcttc ccgcagtttg      120

aggtagaagc caagcaggtc actgataatg accatgctaa tgccagagcg ttttcgcatc      180

tggcttcaaa actgatcgaa acggaggtgg acccatccga cacgatcctt gacattggaa      240

gtgcgcccgc ccgcagaatg tattctaagc acaagtatca ttgtatctgt ccgatgagat      300

gtgcggaaga tccggacaga ttgtataagt atgcaactaa gctgaagaaa aactgtaagg      360

aaataactga taaggaattg gacaagaaaa tgaaggagct ggccgccgtc atgagcgacc      420

ctgacctgga aactgagact atgtgcctcc acgacgacga gtcgtgtcgc tacgaagggc      480

aagtcgctgt ttaccaggat gtatacgcgg ttgacggacc gacaagtctc tatcaccaag      540

ccaataaggg agttagagtc gcctactgga taggctttga caccacccct tttatgttta      600

agaacttggc tggagcatat ccatcatact ctaccaactg ggccgacgaa accgtgttaa      660

cggctcgtaa cataggccta tgcagctctg acgttatgga gcggtcacgt agagggatgt      720

ccattcttag aaagaagtat ttgaaaccat ccaacaatgt tctattctct gttggctcga      780

ccatctacca cgagaagagg gacttactga ggagctggca cctgccgtct gtatttcact      840

tacgtggcaa gcaaaattac acatgtcggt gtgagactat agttagttgc gacgggtacg      900

tcgttaaaag aatagctatc agtccaggcc tgtatgggaa gccttcaggc tatgctgcta      960

cgatgcaccg cgagggattc ttgtgctgca aagtgacaga cacattgaac ggggagaggg     1020

tctcttttcc cgtgtgcacg tatgtgccag ctacattgtg tgaccaaatg actggcatac     1080

tggcaacaga tgtcagtgcg gacgacgcgc aaaaactgct ggttgggctc aaccagcgta     1140

tagtcgtcaa cggtcgcacc cagagaaaca ccaataccat gaaaaattac cttttgcccg     1200

tagtggccca ggcatttgct aggtgggcaa aggaatataa ggaagatcaa gaagatgaaa     1260

ggccactagg actacgagat agacagttag tcatggggtg ttgttgggct tttagaaggc     1320

acaagataac atctatttat aagcgcccgg atacccaaac catcatcaaa gtgaacagcg     1380

atttccactc attcgtgctg cccaggatag gcagtaacac attggagatc gggctgagaa     1440

caagaatcag gaaaatgtta gaggagcaca aggagccgtc acctctcatt accgccgagg     1500

acgtacaaga agctaagtgc gcagccgatg aggctaagga ggtgcgtgaa gccgaggagt     1560

tgcgcgcagc tctaccacct ttggcagctg atgttgagga gcccactctg gaagccgatg     1620

tcgacttgat gttacaagag gctggggccg gctcagtgga gacacctcgt ggcttgataa     1680

aggttaccag ctacgatggc gaggacaaga tcggctctta cgctgtgctt tctccgcagg     1740

ctgtactcaa gagtgaaaaa ttatcttgca tccaccctct cgctgaacaa gtcatagtga     1800

taacacactc tggccgaaaa gggcgttatg ccgtggaacc ataccatggt aaagtagtgg     1860

tgccagaggg acatgcaata cccgtccagg actttcaagc tctgagtgaa agtgccacca     1920

ttgtgtacaa cgaacgtgag ttcgtaaaca ggtacctgca ccatattgcc acacatggag     1980

gagcgctgaa cactgatgaa gaatattaca aaactgtcaa gcccagcgag cacgacggcg     2040

aatacctgta cgacatcgac aggaaacagt gcgtcaagaa agaactagtc actgggctag     2100

ggctcacagg cgagctggtg gatcctccct tccatgaatt cgcctacgag agtctgagaa     2160

cacgaccagc cgctccttac caagtaccaa ccataggggt gtatggcgtg ccaggatcag     2220

gcaagtctgg catcattaaa agcgcagtca ccaaaaaaga tctagtggtg agcgccaaga     2280

aagaaaactg tgcagaaatt ataagggacg tcaagaaaat gaaagggctg gacgtcaatg     2340

ccagaactgt ggactcagtg ctcttgaatg gatgcaaaca ccccgtagag accctgtata     2400

ttgacgaagc ttttgcttgt catgcaggta ctctcagagc gctcatagcc attataagac     2460

ctaaaaaggc agtgctctgc ggggatccca aacagtgcgg tttttttaac atgatgtgcc     2520

tgaaagtgca ttttaaccac gagatttgca cacaagtctt ccacaaaagc atctctcgcc     2580

gttgcactaa atctgtgact tcggtcgtct caaccttgtt ttacgacaaa aaaatgagaa     2640

cgacgaatcc gaaagagact aagattgtga ttgacactac cggcagtacc aaacctaagc     2700

aggacgatct cattctcact tgtttcagag ggtgggtgaa gcagttgcaa atagattaca     2760

aaggcaacga aataatgacg gcagctgcct ctcaagggct gacccgtaaa ggtgtgtatg     2820

ccgttcggta caaggtgaat gaaaatcctc tgtacgcacc cacctcagaa catgtgaacg     2880

tcctactgac ccgcacggag gaccgcatcg tgtggaaaac actagccggc gacccatgga     2940

taaaaacact gactgccaag taccctggga atttcactgc cacgatagag gagtggcaag     3000

cagagcatga tgccatcatg aggcacatct tggagagacc ggaccctacc gacgtcttcc     3060

agaataaggc aaacgtgtgt tgggccaagg ctttagtgcc ggtgctgaag accgctggca     3120

tagacatgac cactgaacaa tggaacactg tggattattt tgaaacggac aaagctcact     3180

cagcagagat agtattgaac caactatgcg tgaggttctt tggactcgat ctggactccg     3240

gtctattttc tgcacccact gttccgttat ccattaggaa taatcactgg gataactccc     3300

cgtcgcctaa catgtacggg ctgaataaag aagtggtccg tcagctctct cgcaggtacc     3360

cacaactgcc tcgggcagtt gccactggaa gagtctatga catgaacact ggtacactgc     3420

gcaattatga tccgcgcata aacctagtac ctgtaaacag aagactgcct catgctttag     3480

tcctccacca taatgaacac ccacagagtg acttttcttc attcgtcagc aaattgaagg     3540

gcagaactgt cctggtggtc ggggaaaagt tgtccgtccc aggcaaaatg gttgactggt     3600

tgtcagaccg gcctgaggct accttcagag ctcggctgga tttaggcatc ccaggtgatg     3660

tgcccaaata tgacataata tttgttaatg tgaggacccc atataaatac catcactatc     3720

agcagtgtga agaccatgcc attaagctta gcatgttgac caagaaagct tgtctgcatc     3780

tgaatcccgg cggaacctgt gtcagcatag gttatggtta cgctgacagg gccagcgaaa     3840

gcatcattgg tgctatagcg cggcagttca agttttcccg ggtatgcaaa ccgaaatcct     3900

cacttgaaga gacggaagtt ctgtttgtat tcattgggta cgatcgcaag gcccgtacgc     3960

acaattctta caagctttca tcaaccttga ccaacattta tacaggttcc agactccacg     4020

aagccggatg tgcaccctca tatcatgtgg tgcgagggga tattgccacg gccaccgaag     4080

gagtgattat aaatgctgct aacagcaaag gacaacctgg cggaggggtg tgcggagcgc     4140

tgtataagaa attcccggaa agcttcgatt tacagccgat cgaagtagga aaagcgcgac     4200

tggtcaaagg tgcagctaaa catatcattc atgccgtagg accaaacttc aacaaagttt     4260

cggaggttga aggtgacaaa cagttggcag aggcttatga gtccatcgct aagattgtca     4320

acgataacaa ttacaagtca gtagcgattc cactgttgtc caccggcatc ttttccggga     4380

acaaagatcg actaacccaa tcattgaacc atttgctgac agctttagac accactgatg     4440

cagatgtagc catatactgc agggacaaga aatgggaaat gactctcaag gaagcagtgg     4500

ctaggagaga agcagtggag gagatatgca tatccgacga ctcttcagtg acagaacctg     4560

atgcagagct ggtgagggtg catccgaaga gttctttggc tggaaggaag ggctacagca     4620

caagcgatgg caaaactttc tcatatttgg aagggaccaa gtttcaccag gcggccaagg     4680

atatagcaga aattaatgcc atgtggcccg ttgcaacgga ggccaatgag caggtatgca     4740

tgtatatcct cggagaaagc atgagcagta ttaggtcgaa atgccccgtc gaagagtcgg     4800

aagcctccac accacctagc acgctgcctt gcttgtgcat ccatgccatg actccagaaa     4860

gagtacagcg cctaaaagcc tcacgtccag aacaaattac tgtgtgctca tcctttccat     4920

tgccgaagta tagaatcact ggtgtgcaga agatccaatg ctcccagcct atattgttct     4980

caccgaaagt gcctgcgtat attcatccaa ggaagtatct cgtggaaaca ccaccggtag     5040

acgagactcc ggagccatcg gcagagaacc aatccacaga ggggacacct gaacaaccac     5100

cacttataac cgaggatgag accaggacta gaacgcctga gccgatcatc atcgaagagg     5160

aagaagagga tagcataagt ttgctgtcag atggcccgac ccaccaggtg ctgcaagtcg     5220

aggcagacat tcacgggccg ccctctgtat ctagctcatc ctggtccatt cctcatgcat     5280

ccgactttga tgtggacagt ttatccatac ttgacaccct ggagggagct agcgtgacca     5340

gcggggcaac gtcagccgag actaactctt acttcgcaaa gagtatggag tttctggcgc     5400

gaccggtgcc tgcgcctcga acagtattca ggaaccctcc acatcccgct ccgcgcacaa     5460

gaacaccgtc acttgcaccc agcagggcct gctcgagaac cagcctagtt tccaccccgc     5520

caggcgtgaa tagggtgatc actagagagg agctcgaggc gcttaccccg tcacgcactc     5580

ctagcaggtc ggtctcgaga accagcctgg tctccaaccc gccaggcgta aatagggtga     5640

ttacaagaga ggagtttgag gcgttcgtag cacaacaaca atgacggttt gatgcgggtg     5700

catacatctt ttcctccgac accggtcaag ggcatttaca acaaaaatca gtaaggcaaa     5760

cggtgctatc cgaagtggtg ttggagagga ccgaattgga gatttcgtat gccccgcgcc     5820

tcgaccaaga aaaagaagaa ttactacgca agaaattaca gttaaatccc acacctgcta     5880

acagaagcag ataccagtcc aggaaggtgg agaacatgaa agccataaca gctagacgta     5940

ttctgcaagg cctagggcat tatttgaagg cagaaggaaa agtggagtgc taccgaaccc     6000

tgcatcctgt tcctttgtat tcatctagtg tgaaccgtgc cttttcaagc cccaaggtcg     6060

cagtggaagc ctgtaacgcc atgttgaaag agaactttcc gactgtggct tcttactgta     6120

ttattccaga gtacgatgcc tatttggaca tggttgacgg agcttcatgc tgcttagaca     6180

ctgccagttt ttgccctgca aagctgcgca gctttccaaa gaaacactcc tatttggaac     6240

ccacaatacg atcggcagtg ccttcagcga tccagaacac gctccagaac gtcctggcag     6300

ctgccacaaa aagaaattgc aatgtcacgc aaatgagaga attgcccgta ttggattcgg     6360

cggcctttaa tgtggaatgc ttcaagaaat atgcgtgtaa taatgaatat tgggaaacgt     6420

ttaaagaaaa ccccatcagg cttactgaag aaaacgtggt aaattacatt accaaattaa     6480

aaggaccaaa agctgctgct ctttttgcga agacacataa tttgaatatg ttgcaggaca     6540

taccaatgga caggtttgta atggacttaa agagagacgt gaaagtgact ccaggaacaa     6600

aacatactga agaacggccc aaggtacagg tgatccaggc tgccgatccg ctagcaacag     6660

cgtatctgtg cggaatccac cgagagctgg ttaggagatt aaatgcggtc ctgcttccga     6720

acattcatac actgtttgat atgtcggctg aagactttga cgctattata gccgagcact     6780

tccagcctgg ggattgtgtt ctggaaactg acatcgcgtc gtttgataaa agtgaggacg     6840

acgccatggc tctgaccgcg ttaatgattc tggaagactt aggtgtggac gcagagctgt     6900

tgacgctgat tgaggcggct ttcggcgaaa tttcatcaat acatttgccc actaaaacta     6960

aatttaaatt cggagccatg atgaaatctg gaatgttcct cacactgttt gtgaacacag     7020

tcattaacat tgtaatcgca agcagagtgt tgagagaacg gctaaccgga tcaccatgtg     7080

cagcattcat tggagatgac aatatcgtga aaggagtcaa atcggacaaa ttaatggcag     7140

acaggtgcgc cacctggttg aatatggaag tcaagattat agatgctgtg gtgggcgaga     7200

aagcgcctta tttctgtgga gggtttattt tgtgtgactc cgtgaccggc acagcgtgcc     7260

gtgtggcaga ccccctaaaa aggctgttta agcttggcaa acctctggca gcagacgatg     7320

aacatgatga tgacaggaga agggcattgc atgaagagtc aacacgctgg aaccgagtgg     7380

gtattctttc agagctgtgc aaggcagtag aatcaaggta tgaaaccgta ggaacttcca     7440

tcatagttat ggccatgact actctagcta gcagtgttaa atcattcagc tacctgagag     7500

gggcccctat aactctctac ggctaacctg aatggactac gacatagtct agtccgccaa     7560

gtctagcata tgggcgcgtg aattcgccac catggcggga cacctggctt cggatttcgc     7620

cttctcgccc cctccaggtg gtggaggtga tgggccaggg gggccggagc cgggctgggt     7680

tgatcctcgg acctggctaa gcttccaagg ccctcctgga gggccaggaa tcgggccggg     7740

ggttgggcca ggctctgagg tgtgggggat tcccccatgc cccccgccgt atgagttctg     7800

tggggggatg gcgtactgtg ggccccaggt tggagtgggg ctagtgcccc aaggcggctt     7860

ggagacctct cagcctgagg gcgaagcagg agtcggggtg gagagcaact ccgatggggc     7920

ctccccggag ccctgcaccg tcacccctgg tgccgtgaag ctggagaagg agaagctgga     7980

gcaaaacccg gaggagtccc aggacatcaa agctctgcag aaagaactcg agcaatttgc     8040

caagctcctg aagcagaaga ggatcaccct gggatataca caggccgatg tggggctcac     8100

cctgggggtt ctatttggga aggtattcag ccaaacgacc atctgccgct ttgaggctct     8160

gcagcttagc ttcaagaaca tgtgtaagct gcggcccttg ctgcagaagt gggtggagga     8220

agctgacaac aatgaaaatc ttcaggagat atgcaaagca gaaaccctcg tgcaggcccg     8280

aaagagaaag cgaaccagta tcgagaaccg agtgagaggc aacctggaga atttgttcct     8340

gcagtgcccg aaacccacac tgcagcagat cagccacatc gcccagcagc ttgggctcga     8400

gaaggatgtg gtccgagtgt ggttctgtaa ccggcgccag aagggcaagc gatcaagcag     8460

cgactatgca caacgagagg attttgaggc tgctgggtct cctttctcag ggggaccagt     8520

gtcctttcct ctggccccag ggccccattt tggtacccca ggctatggga gccctcactt     8580

cactgcactg tactcctcgg tccctttccc tgagggggaa gcctttcccc ctgtctccgt     8640

caccactctg ggctctccca tgcattcaaa ctctagtgag ggcagaggaa gtctgctaac     8700

atgcggtgac gtcgaggaga atcctggccc acaattgatg gctgtcagcg acgcgctgct     8760

cccatctttc tccacgttcg cgtctggccc ggcgggaagg gagaagacac tgcgtcaagc     8820

aggtgccccg aataaccgct ggcgggagga gctctcccac atgaagcgac ttcccccagt     8880

gcttcccggc cgcccctatg acctggcggc ggcgaccgtg gccacagacc tggagagcgg     8940

cggagccggt gcggcttgcg gcggtagcaa cctggcgccc ctacctcgga gagagaccga     9000

ggagttcaac gatctcctgg acctggactt tattctctcc aattcgctga cccatcctcc     9060

ggagtcagtg gccgccaccg tgtcctcgtc agcgtcagcc tcctcttcgt cgtcgccgtc     9120

gagcagcggc cctgccagcg cgccctccac ctgcagcttc acctatccga tccgggccgg     9180

gaacgacccg ggcgtggcgc cgggcggcac gggcggaggc ctcctctatg gcagggagtc     9240

cgctccccct ccgacggctc ccttcaacct ggcggacatc aacgacgtga gcccctcggg     9300

cggcttcgtg gccgagctcc tgcggccaga attggacccg gtgtacattc cgccgcagca     9360

gccgcagccg ccaggtggcg ggctgatggg caagttcgtg ctgaaggcgt cgctgagcgc     9420

ccctggcagc gagtacggca gcccgtcggt catcagcgtc agcaaaggca gccctgacgg     9480

cagccacccg gtggtggtgg cgccctacaa cggcgggccg ccgcgcacgt gccccaagat     9540

caagcaggag gcggtctctt cgtgcaccca cttgggcgct ggaccccctc tcagcaatgg     9600

ccaccggccg gctgcacacg acttccccct ggggcggcag ctccccagca ggactacccc     9660

gaccctgggt cttgaggaag tgctgagcag cagggactgt caccctgccc tgccgcttcc     9720

tcccggcttc catccccacc cggggcccaa ttacccatcc ttcctgcccg atcagatgca     9780

gccgcaagtc ccgccgctcc attaccaaga gctcatgcca cccggttcct gcatgccaga     9840

ggagcccaag ccaaagaggg gaagacgatc gtggccccgg aaaaggaccg ccacccacac     9900

ttgtgattac gcgggctgcg gcaaaaccta cacaaagagt tcccatctca aggcacacct     9960

gcgaacccac acaggtgaga aaccttacca ctgtgactgg gacggctgtg gatggaaatt    10020

cgcccgctca gatgaactga ccaggcacta ccgtaaacac acggggcacc gcccgttcca    10080

gtgccaaaaa tgcgaccgag cattttccag gtcggaccac ctcgccttac acatgaagag    10140

gcatttttct agacaatgta ctaactacgc tttgttgaaa ctcgctggcg atgttgaaag    10200

taaccccggt cctggcgcgc ccatgtacaa catgatggag acggagctga agccgccggg    10260

cccgcagcaa acttcggggg gcggcggcgg caactccacc gcggcggcgg ccggcggcaa    10320

ccagaaaaac agcccggacc gcgtcaagcg gcccatgaat gccttcatgg tgtggtcccg    10380

cgggcagcgg cgcaagatgg cccaggagaa ccccaagatg cacaactcgg agatcagcaa    10440

gcgcctgggc gccgagtgga aacttttgtc ggagacggag aagcggccgt tcatcgacga    10500

ggctaagcgg ctgcgagcgc tgcacatgaa ggagcacccg gattataaat accggccccg    10560

gcggaaaacc aagacgctca tgaagaagga taagtacacg ctgcccggcg ggctgctggc    10620

ccccggcggc aatagcatgg cgagcggggt cggggtgggc gccggcctgg gcgcgggcgt    10680

gaaccagcgc atggacagtt acgcgcacat gaacggctgg agcaacggca gctacagcat    10740

gatgcaggac cagctgggct acccgcagca cccgggcctc aatgcgcacg gcgcagcgca    10800

gatgcagccc atgcaccgct acgacgtgag cgccctgcag tacaactcca tgaccagctc    10860

gcagacctac atgaacggct cgcccaccta cagcatgtcc tactcgcagc agggcacccc    10920

tggcatggct cttggctcca tgggttcggt ggtcaagtcc gaggccagct ccagcccccc    10980

tgtggttacc tcttcctccc actccagggc gccctgccag gccggggacc tccgggacat    11040

gatcagcatg tatctccccg gcgccgaggt gccggaaccc gccgccccca gcagacttca    11100

catgtcccag cactaccaga gcggcccggt gcccggcacg gccattaacg gcacactgcc    11160

cctctcacac atgtgagcgg ccatcgatgt cgacaactaa cttaagctag caacggtttc    11220

cctctagcgg gatcaattcc gccccccccc cctaacgtta ctggccgaag ccgcttggaa    11280

taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat    11340

gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct    11400

ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct    11460

tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc    11520

gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa    11580

ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc    11640

gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg    11700

gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc    11760

ccgaaccacg gggacgtggt tttcctttga aaaacacgat aataccaatt cgccaccatg    11820

gcagaggccc gcacatccct gtctgcccac tgtcggggcc cgctggccac tggcctgcac    11880

ccagacctgg acctcccggg ccgaagcctc gccacccctg cgccttcctg ctaccttctg    11940

ggcagcgaac ccagctctgg cctgggcctc cagcccgaga cccacctccc cgagggcagc    12000

ctgaagcggt gctgcgtctt gggcctaccc cccacctccc cagcctcctc ctcaccctgt    12060

gcctcctccg acgtcacctc catcatccgc tcctcccaga cgtctctggt cacctgtgta    12120

aatggactcc ggagcccccc tctgacggga gatctggggg gcccttccaa gcgggcccgg    12180

cctggccctg catcgacgga cagccatgag ggcagcttgc aacttgaagc ctgccggaag    12240

gcgagcttcc tgaagcagga acccgcggat gagttttcag agctctttgg gcctcaccag    12300

cagggcctgc cgccccccta tcccctgtct cagttgccgc ctggcccaag ccttggaggc    12360

ctggggctgg gcctggcagg cagggtggtg gccgggcggc aggcgtgccg ctgggtggac    12420

tgctgtgcag cctatgagca gcaggaggag ctggtgcggc acatcgagaa gagccacatc    12480

gaccagcgca agggcgagga cttcacctgc ttctgggctg gctgcgtgcg ccgctacaag    12540

cccttcaacg cccgctacaa gctgctcatc cacatgcgag tgcactcggg cgagaagccc    12600

aacaagtgca tgtttgaagg ctgcagcaag gccttctcac ggctggagaa cctcaagatc    12660

cacctgagga gccacacggg cgagaagccg tacctgtgcc agcacccggg ttgccagaag    12720

gccttcagca actccagcga ccgcgccaag caccagcgca cccacctaga cacgaagccg    12780

tacgcctgtc agatccctgg ctgctccaag cgctacacag accccagctc cctccgcaag    12840

cacgtcaagg cccattcagc caaagagcag caggtgcgta agaagctgca tgcgggccct    12900

gacaccgagg ccgacgtcct gaccgagtgt ctggtcctgc agcagctcca cacgtccaca    12960

cagctggctg ccagcgacgg caagggtggc tgtggcctgg gccaggagct gctcccaggt    13020

gtgtatcctg gctccatcac cccccataac ggacttgcat cgggcctcct gcccccagcg    13080

cacgacgtac cttccaggca ccacccgctg gatgccacca ccagttccca ccaccatctg    13140

tcccctctgc ccatggctga gagcacccgg gatgggttgg ggcccggcct cctctcacca    13200

atagtcagcc ccctgaaggg gctggggcca ccgccgctgc ccccatcctc tcagagccat    13260

tctccggggg gccagccctt ccccacactc cccagcaagc cgtcctaccc acccttccag    13320

agccctccac ccccgcctct gcccagccca caaggttacc agggcagttt ccactccatc    13380

cagagttgct tcccctatgg cgactgctac cggatggctg aaccagcagc cggtggggac    13440

ggactggtcg gggagaccca cggtttcaac cccctgcggc ccaatggcta ccacagcctc    13500

agcacgccct tgcctgccac aggctatgag gccctggctg aggcctcatg ccccacagcg    13560

ctgccacagc agccatctga agatgtggtg tccagcggcc ccgaggactg tggcttcttc    13620

cccaatggag cctttgacca ctgcctgggc cacatcccct ccatctacac agacacctga    13680

gcggccgcaa ctaacttaag ctagcaacgg tttccctcta gcgggatcaa ttccgccccc    13740

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat    13800

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt    13860

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt    13920

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc    13980

gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc    14040

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat    14100

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc    14160

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg    14220

tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct    14280

ttgaaaaaca cgataatacc atgaccgagt acaagcccac ggtgcgcctc gccacccgcg    14340

acgacgtccc cagggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc    14400

gccacaccgt cgatccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc    14460

tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg    14520

cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc    14580

gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg    14640

cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc    14700

accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg    14760

ccggggtgcc cgccttcctg gagacctccg cgccccgcaa cctccccttc tacgagcggc    14820

tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga    14880

cccgcaagcc cggtgcctga gaattggcaa gctgcttaca tagaactcgc ggcgattggc    14940

atgccgcctt aaaattttta ttttattttt cttttctttt ccgaatcgga ttttgttttt    15000

aatatttcaa aaaaaaaaaa aaaaaaaaaa aaaacgcgtc gaggggaatt aattcttgaa    15060

gacgaaaggg ccaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt    15120

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca    15180

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt    15240

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga    15300

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa    15360

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct    15420

gctatgtggc gcggtattat cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat    15480

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga    15540

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc    15600

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat    15660

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa    15720

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac    15780

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa    15840

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc    15900

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc    15960

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag    16020

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta    16080

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa    16140

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc    16200

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat    16260

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga    16320

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt    16380

ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata    16440

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac    16500

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg    16560

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg    16620

tgagcattga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag    16680

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct    16740

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc    16800

aggggggcgg agcctatgga aaaacgccag caacgcgagc tctaatacga ctcactatag    16860


<210>  33
<211>  1863
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1863)

<400>  33
atg gca gag gcc cgc aca tcc ctg tct gcc cac tgt cgg ggc ccg ctg         48
Met Ala Glu Ala Arg Thr Ser Leu Ser Ala His Cys Arg Gly Pro Leu           
1               5                   10                  15                

gcc act ggc ctg cac cca gac ctg gac ctc ccg ggc cga agc ctc gcc         96
Ala Thr Gly Leu His Pro Asp Leu Asp Leu Pro Gly Arg Ser Leu Ala           
            20                  25                  30                    

acc cct gcg cct tcc tgc tac ctt ctg ggc agc gaa ccc agc tct ggc        144
Thr Pro Ala Pro Ser Cys Tyr Leu Leu Gly Ser Glu Pro Ser Ser Gly           
        35                  40                  45                        

ctg ggc ctc cag ccc gag acc cac ctc ccc gag ggc agc ctg aag cgg        192
Leu Gly Leu Gln Pro Glu Thr His Leu Pro Glu Gly Ser Leu Lys Arg           
    50                  55                  60                            

tgc tgc gtc ttg ggc cta ccc ccc acc tcc cca gcc tcc tcc tca ccc        240
Cys Cys Val Leu Gly Leu Pro Pro Thr Ser Pro Ala Ser Ser Ser Pro           
65                  70                  75                  80            

tgt gcc tcc tcc gac gtc acc tcc atc atc cgc tcc tcc cag acg tct        288
Cys Ala Ser Ser Asp Val Thr Ser Ile Ile Arg Ser Ser Gln Thr Ser           
                85                  90                  95                

ctg gtc acc tgt gta aat gga ctc cgg agc ccc cct ctg acg gga gat        336
Leu Val Thr Cys Val Asn Gly Leu Arg Ser Pro Pro Leu Thr Gly Asp           
            100                 105                 110                   

ctg ggg ggc cct tcc aag cgg gcc cgg cct ggc cct gca tcg acg gac        384
Leu Gly Gly Pro Ser Lys Arg Ala Arg Pro Gly Pro Ala Ser Thr Asp           
        115                 120                 125                       

agc cat gag ggc agc ttg caa ctt gaa gcc tgc cgg aag gcg agc ttc        432
Ser His Glu Gly Ser Leu Gln Leu Glu Ala Cys Arg Lys Ala Ser Phe           
    130                 135                 140                           

ctg aag cag gaa ccc gcg gat gag ttt tca gag ctc ttt ggg cct cac        480
Leu Lys Gln Glu Pro Ala Asp Glu Phe Ser Glu Leu Phe Gly Pro His           
145                 150                 155                 160           

cag cag ggc ctg ccg ccc ccc tat ccc ctg tct cag ttg ccg cct ggc        528
Gln Gln Gly Leu Pro Pro Pro Tyr Pro Leu Ser Gln Leu Pro Pro Gly           
                165                 170                 175               

cca agc ctt gga ggc ctg ggg ctg ggc ctg gca ggc agg gtg gtg gcc        576
Pro Ser Leu Gly Gly Leu Gly Leu Gly Leu Ala Gly Arg Val Val Ala           
            180                 185                 190                   

ggg cgg cag gcg tgc cgc tgg gtg gac tgc tgt gca gcc tat gag cag        624
Gly Arg Gln Ala Cys Arg Trp Val Asp Cys Cys Ala Ala Tyr Glu Gln           
        195                 200                 205                       

cag gag gag ctg gtg cgg cac atc gag aag agc cac atc gac cag cgc        672
Gln Glu Glu Leu Val Arg His Ile Glu Lys Ser His Ile Asp Gln Arg           
    210                 215                 220                           

aag ggc gag gac ttc acc tgc ttc tgg gct ggc tgc gtg cgc cgc tac        720
Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Val Arg Arg Tyr           
225                 230                 235                 240           

aag ccc ttc aac gcc cgc tac aag ctg ctc atc cac atg cga gtg cac        768
Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val His           
                245                 250                 255               

tcg ggc gag aag ccc aac aag tgc atg ttt gaa ggc tgc agc aag gcc        816
Ser Gly Glu Lys Pro Asn Lys Cys Met Phe Glu Gly Cys Ser Lys Ala           
            260                 265                 270                   

ttc tca cgg ctg gag aac ctc aag atc cac ctg agg agc cac acg ggc        864
Phe Ser Arg Leu Glu Asn Leu Lys Ile His Leu Arg Ser His Thr Gly           
        275                 280                 285                       

gag aag ccg tac ctg tgc cag cac ccg ggt tgc cag aag gcc ttc agc        912
Glu Lys Pro Tyr Leu Cys Gln His Pro Gly Cys Gln Lys Ala Phe Ser           
    290                 295                 300                           

aac tcc agc gac cgc gcc aag cac cag cgc acc cac cta gac acg aag        960
Asn Ser Ser Asp Arg Ala Lys His Gln Arg Thr His Leu Asp Thr Lys           
305                 310                 315                 320           

ccg tac gcc tgt cag atc cct ggc tgc tcc aag cgc tac aca gac ccc       1008
Pro Tyr Ala Cys Gln Ile Pro Gly Cys Ser Lys Arg Tyr Thr Asp Pro           
                325                 330                 335               

agc tcc ctc cgc aag cac gtc aag gcc cat tca gcc aaa gag cag cag       1056
Ser Ser Leu Arg Lys His Val Lys Ala His Ser Ala Lys Glu Gln Gln           
            340                 345                 350                   

gtg cgt aag aag ctg cat gcg ggc cct gac acc gag gcc gac gtc ctg       1104
Val Arg Lys Lys Leu His Ala Gly Pro Asp Thr Glu Ala Asp Val Leu           
        355                 360                 365                       

acc gag tgt ctg gtc ctg cag cag ctc cac acg tcc aca cag ctg gct       1152
Thr Glu Cys Leu Val Leu Gln Gln Leu His Thr Ser Thr Gln Leu Ala           
    370                 375                 380                           

gcc agc gac ggc aag ggt ggc tgt ggc ctg ggc cag gag ctg ctc cca       1200
Ala Ser Asp Gly Lys Gly Gly Cys Gly Leu Gly Gln Glu Leu Leu Pro           
385                 390                 395                 400           

ggt gtg tat cct ggc tcc atc acc ccc cat aac gga ctt gca tcg ggc       1248
Gly Val Tyr Pro Gly Ser Ile Thr Pro His Asn Gly Leu Ala Ser Gly           
                405                 410                 415               

ctc ctg ccc cca gcg cac gac gta cct tcc agg cac cac ccg ctg gat       1296
Leu Leu Pro Pro Ala His Asp Val Pro Ser Arg His His Pro Leu Asp           
            420                 425                 430                   

gcc acc acc agt tcc cac cac cat ctg tcc cct ctg ccc atg gct gag       1344
Ala Thr Thr Ser Ser His His His Leu Ser Pro Leu Pro Met Ala Glu           
        435                 440                 445                       

agc acc cgg gat ggg ttg ggg ccc ggc ctc ctc tca cca ata gtc agc       1392
Ser Thr Arg Asp Gly Leu Gly Pro Gly Leu Leu Ser Pro Ile Val Ser           
    450                 455                 460                           

ccc ctg aag ggg ctg ggg cca ccg ccg ctg ccc cca tcc tct cag agc       1440
Pro Leu Lys Gly Leu Gly Pro Pro Pro Leu Pro Pro Ser Ser Gln Ser           
465                 470                 475                 480           

cat tct ccg ggg ggc cag ccc ttc ccc aca ctc ccc agc aag ccg tcc       1488
His Ser Pro Gly Gly Gln Pro Phe Pro Thr Leu Pro Ser Lys Pro Ser           
                485                 490                 495               

tac cca ccc ttc cag agc cct cca ccc ccg cct ctg ccc agc cca caa       1536
Tyr Pro Pro Phe Gln Ser Pro Pro Pro Pro Pro Leu Pro Ser Pro Gln           
            500                 505                 510                   

ggt tac cag ggc agt ttc cac tcc atc cag agt tgc ttc ccc tat ggc       1584
Gly Tyr Gln Gly Ser Phe His Ser Ile Gln Ser Cys Phe Pro Tyr Gly           
        515                 520                 525                       

gac tgc tac cgg atg gct gaa cca gca gcc ggt ggg gac gga ctg gtc       1632
Asp Cys Tyr Arg Met Ala Glu Pro Ala Ala Gly Gly Asp Gly Leu Val           
    530                 535                 540                           

ggg gag acc cac ggt ttc aac ccc ctg cgg ccc aat ggc tac cac agc       1680
Gly Glu Thr His Gly Phe Asn Pro Leu Arg Pro Asn Gly Tyr His Ser           
545                 550                 555                 560           

ctc agc acg ccc ttg cct gcc aca ggc tat gag gcc ctg gct gag gcc       1728
Leu Ser Thr Pro Leu Pro Ala Thr Gly Tyr Glu Ala Leu Ala Glu Ala           
                565                 570                 575               

tca tgc ccc aca gcg ctg cca cag cag cca tct gaa gat gtg gtg tcc       1776
Ser Cys Pro Thr Ala Leu Pro Gln Gln Pro Ser Glu Asp Val Val Ser           
            580                 585                 590                   

agc ggc ccc gag gac tgt ggc ttc ttc ccc aat gga gcc ttt gac cac       1824
Ser Gly Pro Glu Asp Cys Gly Phe Phe Pro Asn Gly Ala Phe Asp His           
        595                 600                 605                       

tgc ctg ggc cac atc ccc tcc atc tac aca gac acc tga                   1863
Cys Leu Gly His Ile Pro Ser Ile Tyr Thr Asp Thr                           
    610                 615                 620                           


<210>  34
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Ala Arg Thr Ser Leu Ser Ala His Cys Arg Gly Pro Leu 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Asp Leu Asp Leu Pro Gly Arg Ser Leu Ala 
            20                  25                  30          


Thr Pro Ala Pro Ser Cys Tyr Leu Leu Gly Ser Glu Pro Ser Ser Gly 
        35                  40                  45              


Leu Gly Leu Gln Pro Glu Thr His Leu Pro Glu Gly Ser Leu Lys Arg 
    50                  55                  60                  


Cys Cys Val Leu Gly Leu Pro Pro Thr Ser Pro Ala Ser Ser Ser Pro 
65                  70                  75                  80  


Cys Ala Ser Ser Asp Val Thr Ser Ile Ile Arg Ser Ser Gln Thr Ser 
                85                  90                  95      


Leu Val Thr Cys Val Asn Gly Leu Arg Ser Pro Pro Leu Thr Gly Asp 
            100                 105                 110         


Leu Gly Gly Pro Ser Lys Arg Ala Arg Pro Gly Pro Ala Ser Thr Asp 
        115                 120                 125             


Ser His Glu Gly Ser Leu Gln Leu Glu Ala Cys Arg Lys Ala Ser Phe 
    130                 135                 140                 


Leu Lys Gln Glu Pro Ala Asp Glu Phe Ser Glu Leu Phe Gly Pro His 
145                 150                 155                 160 


Gln Gln Gly Leu Pro Pro Pro Tyr Pro Leu Ser Gln Leu Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Gly Gly Leu Gly Leu Gly Leu Ala Gly Arg Val Val Ala 
            180                 185                 190         


Gly Arg Gln Ala Cys Arg Trp Val Asp Cys Cys Ala Ala Tyr Glu Gln 
        195                 200                 205             


Gln Glu Glu Leu Val Arg His Ile Glu Lys Ser His Ile Asp Gln Arg 
    210                 215                 220                 


Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Val Arg Arg Tyr 
225                 230                 235                 240 


Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val His 
                245                 250                 255     


Ser Gly Glu Lys Pro Asn Lys Cys Met Phe Glu Gly Cys Ser Lys Ala 
            260                 265                 270         


Phe Ser Arg Leu Glu Asn Leu Lys Ile His Leu Arg Ser His Thr Gly 
        275                 280                 285             


Glu Lys Pro Tyr Leu Cys Gln His Pro Gly Cys Gln Lys Ala Phe Ser 
    290                 295                 300                 


Asn Ser Ser Asp Arg Ala Lys His Gln Arg Thr His Leu Asp Thr Lys 
305                 310                 315                 320 


Pro Tyr Ala Cys Gln Ile Pro Gly Cys Ser Lys Arg Tyr Thr Asp Pro 
                325                 330                 335     


Ser Ser Leu Arg Lys His Val Lys Ala His Ser Ala Lys Glu Gln Gln 
            340                 345                 350         


Val Arg Lys Lys Leu His Ala Gly Pro Asp Thr Glu Ala Asp Val Leu 
        355                 360                 365             


Thr Glu Cys Leu Val Leu Gln Gln Leu His Thr Ser Thr Gln Leu Ala 
    370                 375                 380                 


Ala Ser Asp Gly Lys Gly Gly Cys Gly Leu Gly Gln Glu Leu Leu Pro 
385                 390                 395                 400 


Gly Val Tyr Pro Gly Ser Ile Thr Pro His Asn Gly Leu Ala Ser Gly 
                405                 410                 415     


Leu Leu Pro Pro Ala His Asp Val Pro Ser Arg His His Pro Leu Asp 
            420                 425                 430         


Ala Thr Thr Ser Ser His His His Leu Ser Pro Leu Pro Met Ala Glu 
        435                 440                 445             


Ser Thr Arg Asp Gly Leu Gly Pro Gly Leu Leu Ser Pro Ile Val Ser 
    450                 455                 460                 


Pro Leu Lys Gly Leu Gly Pro Pro Pro Leu Pro Pro Ser Ser Gln Ser 
465                 470                 475                 480 


His Ser Pro Gly Gly Gln Pro Phe Pro Thr Leu Pro Ser Lys Pro Ser 
                485                 490                 495     


Tyr Pro Pro Phe Gln Ser Pro Pro Pro Pro Pro Leu Pro Ser Pro Gln 
            500                 505                 510         


Gly Tyr Gln Gly Ser Phe His Ser Ile Gln Ser Cys Phe Pro Tyr Gly 
        515                 520                 525             


Asp Cys Tyr Arg Met Ala Glu Pro Ala Ala Gly Gly Asp Gly Leu Val 
    530                 535                 540                 


Gly Glu Thr His Gly Phe Asn Pro Leu Arg Pro Asn Gly Tyr His Ser 
545                 550                 555                 560 


Leu Ser Thr Pro Leu Pro Ala Thr Gly Tyr Glu Ala Leu Ala Glu Ala 
                565                 570                 575     


Ser Cys Pro Thr Ala Leu Pro Gln Gln Pro Ser Glu Asp Val Val Ser 
            580                 585                 590         


Ser Gly Pro Glu Asp Cys Gly Phe Phe Pro Asn Gly Ala Phe Asp His 
        595                 600                 605             


Cys Leu Gly His Ile Pro Ser Ile Tyr Thr Asp Thr 
    610                 615                 620 


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - hKlfGC2For

<400>  35
gcaggaggcg gtctcttcgt gcacc                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - hKlf4GC2Rev

<400>  36
caggtgtgcc ttgagatggg aactc                                             25


<210>  37
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - EcoR1-Sac1-T7M1-VEE

<400>  37
cggaattcga gctctaatac gactcactat agatgggcgg cgcatgagag aagcccag         58


<210>  38
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer - Xba1-BstZ17I-VEE

<400>  38
gctctagagt atacatcctg gtaaacagcg acttgccc                               38


<210>  39
<211>  1056
<212>  DNA
<213>  Vaccinia virus


<220>
<221>  CDS
<222>  (1)..(1056)

<400>  39
atg acg atg aaa atg atg gta cat ata tat ttc gta tca tta ttg tta         48
Met Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Leu Leu           
1               5                   10                  15                

ttg cta ttc cac agt tac gcc ata gac atc gaa aat gaa atc aca gaa         96
Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile Thr Glu           
            20                  25                  30                    

ttc ttc aat aaa atg aga gat act cta cca gct aaa gac tct aaa tgg        144
Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser Lys Trp           
        35                  40                  45                        

ttg aat cca gca tgt atg ttc gga ggc aca atg aat gat ata gcc gct        192
Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Ile Ala Ala           
    50                  55                  60                            

cta gga gag cca ttc agc gca aag tgt cct cct att gaa gac agt ctt        240
Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp Ser Leu           
65                  70                  75                  80            

tta tcg cac aga tat aaa gac tat gtg gtt aaa tgg gaa agg cta gaa        288
Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg Leu Glu           
                85                  90                  95                

aaa aat aga cgg cga cag gtt tct aat aaa cgt gtt aaa cat ggt gat        336
Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His Gly Asp           
            100                 105                 110                   

tta tgg ata gcc aac tat aca tct aaa ttc agt aac cgt agg tat ttg        384
Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg Tyr Leu           
        115                 120                 125                       

tgc acc gta act aca aag aat ggt gac tgt gtt cag ggt ata gtt aga        432
Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile Val Arg           
    130                 135                 140                           

tct cat att aga aaa cct cct tca tgc att cca aaa aca tat gaa cta        480
Ser His Ile Arg Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr Glu Leu           
145                 150                 155                 160           

ggt act cat gat aag tat ggc ata gac tta tac tgt gga att ctt tac        528
Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile Leu Tyr           
                165                 170                 175               

gca aaa cat tat aat aat ata act tgg tat aaa gat aat aag gaa att        576
Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys Glu Ile           
            180                 185                 190                   

aat atc gac gac att aag tat tca caa acg gga aag gaa tta att att        624
Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Glu Leu Ile Ile           
        195                 200                 205                       

cat aat cca gag tta gaa gat agc gga aga tac gac tgt tac gtt cat        672
His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr Val His           
    210                 215                 220                           

tac gac gac gtt aga atc aag aat gat atc gta gta tca aga tgt aaa        720
Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg Cys Lys           
225                 230                 235                 240           

ata ctt acg gtt ata ccg tca caa gac cac agg ttt aaa cta ata cta        768
Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu Ile Leu           
                245                 250                 255               

gat cca aaa atc aac gta acg ata gga gaa cct gcc aat ata aca tgc        816
Asp Pro Lys Ile Asn Val Thr Ile Gly Glu Pro Ala Asn Ile Thr Cys           
            260                 265                 270                   

act gct gtg tca acg tca tta ttg att gac gat gta ctg att gaa tgg        864
Thr Ala Val Ser Thr Ser Leu Leu Ile Asp Asp Val Leu Ile Glu Trp           
        275                 280                 285                       

gaa aat cca tcc gga tgg ctt ata gga ttc gat ttt gat gta tac tct        912
Glu Asn Pro Ser Gly Trp Leu Ile Gly Phe Asp Phe Asp Val Tyr Ser           
    290                 295                 300                           

gtt tta act agt aga ggc ggt att acc gag gcg acc ttg tac ttt gaa        960
Val Leu Thr Ser Arg Gly Gly Ile Thr Glu Ala Thr Leu Tyr Phe Glu           
305                 310                 315                 320           

aat gtt act gaa gaa tat ata ggt aat aca tat aaa tgt cgt gga cac       1008
Asn Val Thr Glu Glu Tyr Ile Gly Asn Thr Tyr Lys Cys Arg Gly His           
                325                 330                 335               

aac tat tat ttt gaa aaa acc ctt aca act aca gta gta ttg gag taa       1056
Asn Tyr Tyr Phe Glu Lys Thr Leu Thr Thr Thr Val Val Leu Glu               
            340                 345                 350                   


<210>  40
<211>  351
<212>  PRT
<213>  Vaccinia virus

<400>  40

Met Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile Thr Glu 
            20                  25                  30          


Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser Lys Trp 
        35                  40                  45              


Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Ile Ala Ala 
    50                  55                  60                  


Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp Ser Leu 
65                  70                  75                  80  


Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg Leu Glu 
                85                  90                  95      


Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His Gly Asp 
            100                 105                 110         


Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg Tyr Leu 
        115                 120                 125             


Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile Val Arg 
    130                 135                 140                 


Ser His Ile Arg Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr Glu Leu 
145                 150                 155                 160 


Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile Leu Tyr 
                165                 170                 175     


Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys Glu Ile 
            180                 185                 190         


Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Glu Leu Ile Ile 
        195                 200                 205             


His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr Val His 
    210                 215                 220                 


Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg Cys Lys 
225                 230                 235                 240 


Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu Ile Leu 
                245                 250                 255     


Asp Pro Lys Ile Asn Val Thr Ile Gly Glu Pro Ala Asn Ile Thr Cys 
            260                 265                 270         


Thr Ala Val Ser Thr Ser Leu Leu Ile Asp Asp Val Leu Ile Glu Trp 
        275                 280                 285             


Glu Asn Pro Ser Gly Trp Leu Ile Gly Phe Asp Phe Asp Val Tyr Ser 
    290                 295                 300                 


Val Leu Thr Ser Arg Gly Gly Ile Thr Glu Ala Thr Leu Tyr Phe Glu 
305                 310                 315                 320 


Asn Val Thr Glu Glu Tyr Ile Gly Asn Thr Tyr Lys Cys Arg Gly His 
                325                 330                 335     


Asn Tyr Tyr Phe Glu Lys Thr Leu Thr Thr Thr Val Val Leu Glu 
            340                 345                 350     


