                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Polypeptides having organophosphorous hydrolase activity

<130>  12431-WO-PCT

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  966
<212>  DNA
<213>  Ciona savignyi


<220>
<221>  CDS
<222>  (1)..(963)

<400>  1
atg gca gac tca gga atc cct gtt atc aaa gag cct caa ttc aca atg         48
Met Ala Asp Ser Gly Ile Pro Val Ile Lys Glu Pro Gln Phe Thr Met           
1               5                   10                  15                

atc act aaa gac atc aac ggc tca gaa ggc cct gtt ttc gac aca aaa         96
Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly Pro Val Phe Asp Thr Lys           
            20                  25                  30                    

ggt cgc ttc tat gcg gtt gcg cct atg gag gct gcg gac gag aac cgc        144
Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ala Ala Asp Glu Asn Arg           
        35                  40                  45                        

gag cct ggt cag ttt act gac ggc atc gca gga aaa ctt tac caa gtt        192
Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala Gly Lys Leu Tyr Gln Val           
    50                  55                  60                            

gac ctt gac tca ggc gtt aaa caa gtt gtt tgg aca cct cat ttt gac        240
Asp Leu Asp Ser Gly Val Lys Gln Val Val Trp Thr Pro His Phe Asp           
65                  70                  75                  80            

ggc tat gga ggt cgc cct gct ggt tgt caa tca gac cat gag gac aac        288
Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp His Glu Asp Asn           
                85                  90                  95                

atc tgg atc gca gac atg cgc ctt ggc ctt ctt aag tat aac gtt gag        336
Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asn Val Glu           
            100                 105                 110                   

ggt aac tgt aaa caa ttc ggc aag gtt gac aca gac gga gag cct ctt        384
Gly Asn Cys Lys Gln Phe Gly Lys Val Asp Thr Asp Gly Glu Pro Leu           
        115                 120                 125                       

aac ggt ggt aac gac ctt gta ttt gac cgc gac ggt aac ctt tgg ttt        432
Asn Gly Gly Asn Asp Leu Val Phe Asp Arg Asp Gly Asn Leu Trp Phe           
    130                 135                 140                           

aca ggc cct gga tca cct atc gca cct tca cct gag gac cgc gag act        480
Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser Pro Glu Asp Arg Glu Thr           
145                 150                 155                 160           

atc ttt act gag cct tca gga cgc atc tac tgc ctt cct aaa ggt ggc        528
Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr Cys Leu Pro Lys Gly Gly           
                165                 170                 175               

gag gtt cct atc aag gtt gac gac aac ttt atg ttc tgt aac gga atc        576
Glu Val Pro Ile Lys Val Asp Asp Asn Phe Met Phe Cys Asn Gly Ile           
            180                 185                 190                   

gcg gta tca ggt aac atg ctt ctt gtt gct gag act gtt aag aac cag        624
Ala Val Ser Gly Asn Met Leu Leu Val Ala Glu Thr Val Lys Asn Gln           
        195                 200                 205                       

atc atc gct tac gac atc acg gga cct ggc aaa gtt aag aat cgt cgc        672
Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly Lys Val Lys Asn Arg Arg           
    210                 215                 220                           

ctt tgg gcg aaa gtt cct aaa cct gca ggc aat ggt ggc cct gac gga        720
Leu Trp Ala Lys Val Pro Lys Pro Ala Gly Asn Gly Gly Pro Asp Gly           
225                 230                 235                 240           

atg gac ttt gac gag act ggt cgc ctt ctt gtt gct aac tat ggc gct        768
Met Asp Phe Asp Glu Thr Gly Arg Leu Leu Val Ala Asn Tyr Gly Ala           
                245                 250                 255               

tca cac atc gag gta tat cct cct ggc ggt tca cag gag cct atc gta        816
Ser His Ile Glu Val Tyr Pro Pro Gly Gly Ser Gln Glu Pro Ile Val           
            260                 265                 270                   

cgc ctt aag tgt cct ttc aaa aca ctt tca aac ctt cac ttt gct cgc        864
Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser Asn Leu His Phe Ala Arg           
        275                 280                 285                       

aac tca aac atc tgt tac gtt act gag cat gac aat ggt ggc gtt tgg        912
Asn Ser Asn Ile Cys Tyr Val Thr Glu His Asp Asn Gly Gly Val Trp           
    290                 295                 300                           

aag ttc gag tgg gac tgt aaa ggt gct cct atg tat tgt gac act aaa        960
Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro Met Tyr Cys Asp Thr Lys           
305                 310                 315                 320           

ctt taa                                                                966
Leu                                                                       
                                                                          


<210>  2
<211>  321
<212>  PRT
<213>  Ciona savignyi

<400>  2

Met Ala Asp Ser Gly Ile Pro Val Ile Lys Glu Pro Gln Phe Thr Met 
1               5                   10                  15      


Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly Pro Val Phe Asp Thr Lys 
            20                  25                  30          


Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ala Ala Asp Glu Asn Arg 
        35                  40                  45              


Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala Gly Lys Leu Tyr Gln Val 
    50                  55                  60                  


Asp Leu Asp Ser Gly Val Lys Gln Val Val Trp Thr Pro His Phe Asp 
65                  70                  75                  80  


Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp His Glu Asp Asn 
                85                  90                  95      


Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asn Val Glu 
            100                 105                 110         


Gly Asn Cys Lys Gln Phe Gly Lys Val Asp Thr Asp Gly Glu Pro Leu 
        115                 120                 125             


Asn Gly Gly Asn Asp Leu Val Phe Asp Arg Asp Gly Asn Leu Trp Phe 
    130                 135                 140                 


Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser Pro Glu Asp Arg Glu Thr 
145                 150                 155                 160 


Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr Cys Leu Pro Lys Gly Gly 
                165                 170                 175     


Glu Val Pro Ile Lys Val Asp Asp Asn Phe Met Phe Cys Asn Gly Ile 
            180                 185                 190         


Ala Val Ser Gly Asn Met Leu Leu Val Ala Glu Thr Val Lys Asn Gln 
        195                 200                 205             


Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly Lys Val Lys Asn Arg Arg 
    210                 215                 220                 


Leu Trp Ala Lys Val Pro Lys Pro Ala Gly Asn Gly Gly Pro Asp Gly 
225                 230                 235                 240 


Met Asp Phe Asp Glu Thr Gly Arg Leu Leu Val Ala Asn Tyr Gly Ala 
                245                 250                 255     


Ser His Ile Glu Val Tyr Pro Pro Gly Gly Ser Gln Glu Pro Ile Val 
            260                 265                 270         


Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser Asn Leu His Phe Ala Arg 
        275                 280                 285             


Asn Ser Asn Ile Cys Tyr Val Thr Glu His Asp Asn Gly Gly Val Trp 
    290                 295                 300                 


Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro Met Tyr Cys Asp Thr Lys 
305                 310                 315                 320 


Leu 
    


<210>  3
<211>  945
<212>  DNA
<213>  Ciona intestinalis


<220>
<221>  CDS
<222>  (1)..(942)

<400>  3
atg gcg aaa aca atc gag cct aag ttc aaa atg gta act aaa gac atc         48
Met Ala Lys Thr Ile Glu Pro Lys Phe Lys Met Val Thr Lys Asp Ile           
1               5                   10                  15                

gac ggc tca gag ggt cct gtt ttc gac act aaa ggt cgc ttc tat gca         96
Asp Gly Ser Glu Gly Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala           
            20                  25                  30                    

gta gct cct atg gag tca gct gac gac aac cgc gag act ggc caa ttc        144
Val Ala Pro Met Glu Ser Ala Asp Asp Asn Arg Glu Thr Gly Gln Phe           
        35                  40                  45                        

ctt gac gga atc gct ggc aaa ctt tac tca gta aac ctt aac act ggt        192
Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser Val Asn Leu Asn Thr Gly           
    50                  55                  60                            

gag aaa caa gtt gtt tgc act cct cag ttt aac ggc tat ggt ggt cgc        240
Glu Lys Gln Val Val Cys Thr Pro Gln Phe Asn Gly Tyr Gly Gly Arg           
65                  70                  75                  80            

cct gct ggc tgt caa tca gac aaa gag gac aac atc tgg atc gca gac        288
Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp Asn Ile Trp Ile Ala Asp           
                85                  90                  95                

atg cgc ctt ggc ctt ctt aag tat gac ggc aaa ggc aac tgc aaa caa        336
Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly Lys Gly Asn Cys Lys Gln           
            100                 105                 110                   

ttc tca gtt gtt gac act gac gga aac cct ctt aat ggc gct aac gac        384
Phe Ser Val Val Asp Thr Asp Gly Asn Pro Leu Asn Gly Ala Asn Asp           
        115                 120                 125                       

ctt gta ttt gac gac gac ggc aac ctt tgg ttt act gga cct ggc tca        432
Leu Val Phe Asp Asp Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser           
    130                 135                 140                           

cct gtt gct cct tca gta gag gac cgc acg acg atc ttc gcg gag cct        480
Pro Val Ala Pro Ser Val Glu Asp Arg Thr Thr Ile Phe Ala Glu Pro           
145                 150                 155                 160           

aca ggt cgc atc tac tgc ctt cct aaa ggc tca gag gtt cct atc aaa        528
Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly Ser Glu Val Pro Ile Lys           
                165                 170                 175               

gtt gac gac aac ttc cgc ttt tgt aac ggc atc gct gta aca ggc aaa        576
Val Asp Asp Asn Phe Arg Phe Cys Asn Gly Ile Ala Val Thr Gly Lys           
            180                 185                 190                   

ctt ctt ctt gta gct gag aca atg act aaa caa atc atc gca tac gac        624
Leu Leu Leu Val Ala Glu Thr Met Thr Lys Gln Ile Ile Ala Tyr Asp           
        195                 200                 205                       

gtt act ggt cct ggc aac gta act aat cgt cgc atc tgg tct aaa gtt        672
Val Thr Gly Pro Gly Asn Val Thr Asn Arg Arg Ile Trp Ser Lys Val           
    210                 215                 220                           

cct aaa ggc gct gag cag gga ggt cct gac gga atg gac ttc gac gaa        720
Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp Gly Met Asp Phe Asp Glu           
225                 230                 235                 240           

cgc gga tgc ctt ctt gtt gct aac cat ggt ggt tca cac atc gag gta        768
Arg Gly Cys Leu Leu Val Ala Asn His Gly Gly Ser His Ile Glu Val           
                245                 250                 255               

tac cct cct gag gga ggc gac gag cct atc atc cgc gta cgc tgc cct        816
Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile Ile Arg Val Arg Cys Pro           
            260                 265                 270                   

ttc aaa acg cct tca aac gtt cat ttc gca cag aac tca aac gta tgc        864
Phe Lys Thr Pro Ser Asn Val His Phe Ala Gln Asn Ser Asn Val Cys           
        275                 280                 285                       

tat gtt act gag cac gac aca aac gga gtt tgg gct ttc gag tgg gac        912
Tyr Val Thr Glu His Asp Thr Asn Gly Val Trp Ala Phe Glu Trp Asp           
    290                 295                 300                           

tgc aaa gga gca ctt atg tac tgt gac aaa taa                            945
Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys                                   
305                 310                                                   


<210>  4
<211>  314
<212>  PRT
<213>  Ciona intestinalis

<400>  4

Met Ala Lys Thr Ile Glu Pro Lys Phe Lys Met Val Thr Lys Asp Ile 
1               5                   10                  15      


Asp Gly Ser Glu Gly Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala 
            20                  25                  30          


Val Ala Pro Met Glu Ser Ala Asp Asp Asn Arg Glu Thr Gly Gln Phe 
        35                  40                  45              


Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser Val Asn Leu Asn Thr Gly 
    50                  55                  60                  


Glu Lys Gln Val Val Cys Thr Pro Gln Phe Asn Gly Tyr Gly Gly Arg 
65                  70                  75                  80  


Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp Asn Ile Trp Ile Ala Asp 
                85                  90                  95      


Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly Lys Gly Asn Cys Lys Gln 
            100                 105                 110         


Phe Ser Val Val Asp Thr Asp Gly Asn Pro Leu Asn Gly Ala Asn Asp 
        115                 120                 125             


Leu Val Phe Asp Asp Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser 
    130                 135                 140                 


Pro Val Ala Pro Ser Val Glu Asp Arg Thr Thr Ile Phe Ala Glu Pro 
145                 150                 155                 160 


Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly Ser Glu Val Pro Ile Lys 
                165                 170                 175     


Val Asp Asp Asn Phe Arg Phe Cys Asn Gly Ile Ala Val Thr Gly Lys 
            180                 185                 190         


Leu Leu Leu Val Ala Glu Thr Met Thr Lys Gln Ile Ile Ala Tyr Asp 
        195                 200                 205             


Val Thr Gly Pro Gly Asn Val Thr Asn Arg Arg Ile Trp Ser Lys Val 
    210                 215                 220                 


Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp Gly Met Asp Phe Asp Glu 
225                 230                 235                 240 


Arg Gly Cys Leu Leu Val Ala Asn His Gly Gly Ser His Ile Glu Val 
                245                 250                 255     


Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile Ile Arg Val Arg Cys Pro 
            260                 265                 270         


Phe Lys Thr Pro Ser Asn Val His Phe Ala Gln Asn Ser Asn Val Cys 
        275                 280                 285             


Tyr Val Thr Glu His Asp Thr Asn Gly Val Trp Ala Phe Glu Trp Asp 
    290                 295                 300                 


Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
305                 310                 


<210>  5
<211>  1032
<212>  DNA
<213>  Ciona savignyi


<220>
<221>  CDS
<222>  (1)..(1029)

<400>  5
atg gca cat cac cac cac cat cac gtg ggt acc ggt tcg aat gat gac         48
Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp           
1               5                   10                  15                

gac gac aag agt ccg gat ccc gca gac tca gga atc cct gtt atc aaa         96
Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys           
            20                  25                  30                    

gag cct caa ttc aca atg atc act aaa gac atc aac ggc tca gaa ggc        144
Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly           
        35                  40                  45                        

cct gtt ttc gac aca aaa ggt cgc ttc tat gcg gtt gcg cct atg gag        192
Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu           
    50                  55                  60                            

gct gcg gac gag aac cgc gag cct ggt cag ttt act gac ggc atc gca        240
Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala           
65                  70                  75                  80            

gga aaa ctt tac caa gtt gac ctt gac tca ggc gtt aaa caa gtt gtt        288
Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val           
                85                  90                  95                

tgg aca cct cat ttt gac ggc tat gga ggt cgc cct gct ggt tgt caa        336
Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln           
            100                 105                 110                   

tca gac cat gag gac aac atc tgg atc gca gac atg cgc ctt ggc ctt        384
Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu           
        115                 120                 125                       

ctt aag tat aac gtt gag ggt aac tgt aaa caa ttc ggc aag gtt gac        432
Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp           
    130                 135                 140                           

aca gac gga gag cct ctt aac ggt ggt aac gac ctt gta ttt gac cgc        480
Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg           
145                 150                 155                 160           

gac ggt aac ctt tgg ttt aca ggc cct gga tca cct atc gca cct tca        528
Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser           
                165                 170                 175               

cct gag gac cgc gag act atc ttt act gag cct tca gga cgc atc tac        576
Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr           
            180                 185                 190                   

tgc ctt cct aaa ggt ggc gag gtt cct atc aag gtt gac gac aac ttt        624
Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe           
        195                 200                 205                       

atg ttc tgt aac gga atc gcg gta tca ggt aac atg ctt ctt gtt gct        672
Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala           
    210                 215                 220                           

gag act gtt aag aac cag atc atc gct tac gac atc acg gga cct ggc        720
Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly           
225                 230                 235                 240           

aaa gtt aag aat cgt cgc ctt tgg gcg aaa gtt cct aaa cct gca ggc        768
Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly           
                245                 250                 255               

aat ggt ggc cct gac gga atg gac ttt gac gag act ggt cgc ctt ctt        816
Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu           
            260                 265                 270                   

gtt gct aac tat ggc gct tca cac atc gag gta tat cct cct ggc ggt        864
Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly           
        275                 280                 285                       

tca cag gag cct atc gta cgc ctt aag tgt cct ttc aaa aca ctt tca        912
Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser           
    290                 295                 300                           

aac ctt cac ttt gct cgc aac tca aac atc tgt tac gtt act gag cat        960
Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His           
305                 310                 315                 320           

gac aat ggt ggc gtt tgg aag ttc gag tgg gac tgt aaa ggt gct cct       1008
Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro           
                325                 330                 335               

atg tat tgt gac act aaa ctt taa                                       1032
Met Tyr Cys Asp Thr Lys Leu                                               
            340                                                           


<210>  6
<211>  343
<212>  PRT
<213>  Ciona savignyi

<400>  6

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  7
<211>  1011
<212>  DNA
<213>  Ciona intestinalis


<220>
<221>  CDS
<222>  (1)..(1008)

<400>  7
atg gca cat cac cac cac cat cac gtg ggt acc ggt tcg aat gat gac         48
Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp           
1               5                   10                  15                

gac gac aag agt ccg gat ccc gcg aaa aca atc gag cct aag ttc aaa         96
Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys           
            20                  25                  30                    

atg gta act aaa gac atc gac ggc tca gag ggt cct gtt ttc gac act        144
Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr           
        35                  40                  45                        

aaa ggt cgc ttc tat gca gta gct cct atg gag tca gct gac gac aac        192
Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ser Ala Asp Asp Asn           
    50                  55                  60                            

cgc gag act ggc caa ttc ctt gac gga atc gct ggc aaa ctt tac tca        240
Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser           
65                  70                  75                  80            

gta aac ctt aac act ggt gag aaa caa gtt gtt tgc act cct cag ttt        288
Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe           
                85                  90                  95                

aac ggc tat ggt ggt cgc cct gct ggc tgt caa tca gac aaa gag gac        336
Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp           
            100                 105                 110                   

aac atc tgg atc gca gac atg cgc ctt ggc ctt ctt aag tat gac ggc        384
Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly           
        115                 120                 125                       

aaa ggc aac tgc aaa caa ttc tca gtt gtt gac act gac gga aac cct        432
Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro           
    130                 135                 140                           

ctt aat ggc gct aac gac ctt gta ttt gac gac gac ggc aac ctt tgg        480
Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp           
145                 150                 155                 160           

ttt act gga cct ggc tca cct gtt gct cct tca gta gag gac cgc acg        528
Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Glu Asp Arg Thr           
                165                 170                 175               

acg atc ttc gcg gag cct aca ggt cgc atc tac tgc ctt cct aaa ggc        576
Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly           
            180                 185                 190                   

tca gag gtt cct atc aaa gtt gac gac aac ttc cgc ttt tgt aac ggc        624
Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly           
        195                 200                 205                       

atc gct gta aca ggc aaa ctt ctt ctt gta gct gag aca atg act aaa        672
Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys           
    210                 215                 220                           

caa atc atc gca tac gac gtt act ggt cct ggc aac gta act aat cgt        720
Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg           
225                 230                 235                 240           

cgc atc tgg tct aaa gtt cct aaa ggc gct gag cag gga ggt cct gac        768
Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp           
                245                 250                 255               

gga atg gac ttc gac gaa cgc gga tgc ctt ctt gtt gct aac cat ggt        816
Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly           
            260                 265                 270                   

ggt tca cac atc gag gta tac cct cct gag gga ggc gac gag cct atc        864
Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile           
        275                 280                 285                       

atc cgc gta cgc tgc cct ttc aaa acg cct tca aac gtt cat ttc gca        912
Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala           
    290                 295                 300                           

cag aac tca aac gta tgc tat gtt act gag cac gac aca aac gga gtt        960
Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val           
305                 310                 315                 320           

tgg gct ttc gag tgg gac tgc aaa gga gca ctt atg tac tgt gac aaa       1008
Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys           
                325                 330                 335               

taa                                                                   1011


<210>  8
<211>  336
<212>  PRT
<213>  Ciona intestinalis

<400>  8

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ser Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Glu Asp Arg Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  9
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  9

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Ala Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  10
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  10

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Gly Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  11
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  11

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Ile Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  12
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  12

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Val Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  13
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  13

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Leu Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  14
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  14

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ser Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  15
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  15

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Cys Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  16
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  16

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Phe Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  17
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  17

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Ile Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  18
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  18

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Leu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  19
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  19

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Val Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  20
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  20

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Phe Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  21
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  21

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Ile Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  22
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  22

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Leu Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  23
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  23

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Val Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  24
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  24

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Met Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Tyr Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  25
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  25

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn His Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  26
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  CSAV variant

<400>  26

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Asp Ser Gly Ile Pro Val Ile Lys 
            20                  25                  30          


Glu Pro Gln Phe Thr Met Ile Thr Lys Asp Ile Asn Gly Ser Glu Gly 
        35                  40                  45              


Pro Val Phe Asp Thr Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu 
    50                  55                  60                  


Ala Ala Asp Glu Asn Arg Glu Pro Gly Gln Phe Thr Asp Gly Ile Ala 
65                  70                  75                  80  


Gly Lys Leu Tyr Gln Val Asp Leu Asp Ser Gly Val Lys Gln Val Val 
                85                  90                  95      


Trp Thr Pro His Phe Asp Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln 
            100                 105                 110         


Ser Asp His Glu Asp Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu 
        115                 120                 125             


Leu Lys Tyr Asn Val Glu Gly Asn Cys Lys Gln Phe Gly Lys Val Asp 
    130                 135                 140                 


Thr Asp Gly Glu Pro Leu Asn Gly Gly Asn Asp Leu Val Phe Asp Arg 
145                 150                 155                 160 


Asp Gly Asn Leu Trp Phe Thr Gly Pro Gly Ser Pro Ile Ala Pro Ser 
                165                 170                 175     


Pro Glu Asp Arg Glu Thr Ile Phe Thr Glu Pro Ser Gly Arg Ile Tyr 
            180                 185                 190         


Cys Leu Pro Lys Gly Gly Glu Val Pro Ile Lys Val Asp Asp Asn Phe 
        195                 200                 205             


Met Phe Cys Asn Gly Ile Ala Val Ser Gly Asn Met Leu Leu Val Ala 
    210                 215                 220                 


Glu Thr Val Lys Asn Gln Ile Ile Ala Tyr Asp Ile Thr Gly Pro Gly 
225                 230                 235                 240 


Lys Val Lys Asn Arg Arg Leu Trp Ala Lys Val Pro Lys Pro Ala Gly 
                245                 250                 255     


Asn Gly Gly Pro Asp Gly Met Asp Phe Asp Glu Thr Gly Arg Leu Leu 
            260                 265                 270         


Val Ala Asn Phe Gly Ala Ser His Ile Glu Val Tyr Pro Pro Gly Gly 
        275                 280                 285             


Ser Gln Glu Pro Ile Val Arg Leu Lys Cys Pro Phe Lys Thr Leu Ser 
    290                 295                 300                 


Asn Leu His Phe Ala Arg Asn Ser Asn Ile Cys Tyr Val Thr Glu His 
305                 310                 315                 320 


Asp Asn Gly Gly Val Trp Lys Phe Glu Trp Asp Cys Lys Gly Ala Pro 
                325                 330                 335     


Met Tyr Cys Asp Thr Lys Leu 
            340             


<210>  27
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  CINT variant

<400>  27

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ser Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Phe Asp Arg Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  28
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  CINT variant

<400>  28

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ser Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Val Asp Arg Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  29
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  CINT variant

<400>  29

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Ser Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Glu Asp Ala Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  30
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  CINT variant

<400>  30

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Leu Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Glu Asp Arg Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  31
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  CINT variant

<400>  31

Met Ala His His His His His His Val Gly Thr Gly Ser Asn Asp Asp 
1               5                   10                  15      


Asp Asp Lys Ser Pro Asp Pro Ala Lys Thr Ile Glu Pro Lys Phe Lys 
            20                  25                  30          


Met Val Thr Lys Asp Ile Asp Gly Ser Glu Gly Pro Val Phe Asp Thr 
        35                  40                  45              


Lys Gly Arg Phe Tyr Ala Val Ala Pro Met Glu Arg Ala Asp Asp Asn 
    50                  55                  60                  


Arg Glu Thr Gly Gln Phe Leu Asp Gly Ile Ala Gly Lys Leu Tyr Ser 
65                  70                  75                  80  


Val Asn Leu Asn Thr Gly Glu Lys Gln Val Val Cys Thr Pro Gln Phe 
                85                  90                  95      


Asn Gly Tyr Gly Gly Arg Pro Ala Gly Cys Gln Ser Asp Lys Glu Asp 
            100                 105                 110         


Asn Ile Trp Ile Ala Asp Met Arg Leu Gly Leu Leu Lys Tyr Asp Gly 
        115                 120                 125             


Lys Gly Asn Cys Lys Gln Phe Ser Val Val Asp Thr Asp Gly Asn Pro 
    130                 135                 140                 


Leu Asn Gly Ala Asn Asp Leu Val Phe Asp Asp Asp Gly Asn Leu Trp 
145                 150                 155                 160 


Phe Thr Gly Pro Gly Ser Pro Val Ala Pro Ser Val Glu Asp Arg Thr 
                165                 170                 175     


Thr Ile Phe Ala Glu Pro Thr Gly Arg Ile Tyr Cys Leu Pro Lys Gly 
            180                 185                 190         


Ser Glu Val Pro Ile Lys Val Asp Asp Asn Phe Arg Phe Cys Asn Gly 
        195                 200                 205             


Ile Ala Val Thr Gly Lys Leu Leu Leu Val Ala Glu Thr Met Thr Lys 
    210                 215                 220                 


Gln Ile Ile Ala Tyr Asp Val Thr Gly Pro Gly Asn Val Thr Asn Arg 
225                 230                 235                 240 


Arg Ile Trp Ser Lys Val Pro Lys Gly Ala Glu Gln Gly Gly Pro Asp 
                245                 250                 255     


Gly Met Asp Phe Asp Glu Arg Gly Cys Leu Leu Val Ala Asn His Gly 
            260                 265                 270         


Gly Ser His Ile Glu Val Tyr Pro Pro Glu Gly Gly Asp Glu Pro Ile 
        275                 280                 285             


Ile Arg Val Arg Cys Pro Phe Lys Thr Pro Ser Asn Val His Phe Ala 
    290                 295                 300                 


Gln Asn Ser Asn Val Cys Tyr Val Thr Glu His Asp Thr Asn Gly Val 
305                 310                 315                 320 


Trp Ala Phe Glu Trp Asp Cys Lys Gly Ala Leu Met Tyr Cys Asp Lys 
                325                 330                 335     


<210>  32
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  32
cggttctcgt ccgcagcctc agcaggcgca accgcataga agcg                        44


<210>  33
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  33
cggttctcgt ccgcagcctc accaggcgca accgcataga agcg                        44


<210>  34
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  34
ggtctgattg acaaccagca gggatacctc catagccgtc aaaatgag                    48


<210>  35
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  35
ggtctgattg acaaccagca ggaacacctc catagccgtc aaaatgag                    48


<210>  36
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  36
ggtctgattg acaaccagca ggaagacctc catagccgtc aaaatgag                    48


<210>  37
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  37
cctcatggtc tgattgacaa cctgaagggc gacctccata gccgtc                      46


<210>  38
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  38
cctcatggtc tgattgacaa ccacaagggc gacctccata gccgtc                      46


<210>  39
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  39
cagtaaagat agtctcgcgg tcaaaaggtg aaggtgcgat aggtgatc                    48


<210>  40
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  40
cagtaaagat agtctcgcgg tcgataggtg aaggtgcgat aggtgatc                    48


<210>  41
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  41
cagtaaagat agtctcgcgg tcaagaggtg aaggtgcgat aggtgatc                    48


<210>  42
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  42
cagtaaagat agtctcgcgg tcaacaggtg aaggtgcgat aggtgatc                    48


<210>  43
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  43
gaaggctcag taaagatagt ctcaaagtcc tcaggtgaag gtgcgatag                   49


<210>  44
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  44
gaaggctcag taaagatagt ctcgatgtcc tcaggtgaag gtgcgatag                   49


<210>  45
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  45
gaaggctcag taaagatagt ctcaaggtcc tcaggtgaag gtgcgatag                   49


<210>  46
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  46
gaaggctcag taaagatagt ctcaacgtcc tcaggtgaag gtgcgatag                   49


<210>  47
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  47
gaaggctcag taaagatagt ctccatgtcc tcaggtgaag gtgcgatag                   49


<210>  48
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  48
gatatacctc gatgtgtgaa gcgccgtggt tagcaacaag aaggcgacca g                51


<210>  49
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  49
gatatacctc gatgtgtgaa gcgccaaagt tagcaacaag aaggcgacca g                51


<210>  50
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  50
gaagatcgtc gtgcggtcga atactgaagg agcaacaggt gag                         43


<210>  51
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  51
gaagatcgtc gtgcggtcaa ctactgaagg agcaacaggt gag                         43


<210>  52
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  52
ctccgcgaag atcgtcgtag cgtcctctac tgaaggagca acag                        44


<210>  53
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  53
ctcgcggttg tcgtcagcaa gctccatagg agctactgca tag                         43


<210>  54
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Mutagenic primer

<400>  54
ctcgcggttg tcgtcagcgc gctccatagg agctactgca tag                         43


