                         SEQUENCE LISTING

<110>  Temple University - Of the Commonwealth System of Higher 
       Education
       Langford, Teresa Dianne
       Merali, Salim
 
<120>  Method for Determining Disease Severity in Tauopathy-Related 
       Neurodegenerative Disorders

<130>  35926-0458-00-WO

<150>  US 61/652,510
<151>  2012-05-29

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  1
tagttcaaga caacagagac aaagctaaga tgaggaagtt ctgtacagtt taggaaatag       60

aggctttcaa agataattcg cagtgatgtg aaactggcct cccaagccct gataacaaca      120

tggccaacgc cctggccagc gccacttgcg agcgctgcaa gggcggcttt gcgcccgctg      180

agaagatcgt gaacagtaat ggggagctgt accatgagca gtgtttcgtg tgcgctcagt      240

gcttccagca gttcccagaa ggactcttct atgagtttga aggaagaaag tactgtgaac      300

atgactttca gatgctcttt gccccttgct gtcatcagtg tggtgaattc atcattggcc      360

gagttatcaa agccatgaat aacagctggc atccggagtg cttccgctgt gacctctgcc      420

aggaagttct ggcagatatc gggtttgtca agaatgctgg gagacacctg tgtcgcccct      480

gtcataatcg tgagaaagcc agaggccttg ggaaatacat ctgccagaaa tgccatgcta      540

tcatcgatga gcagcctctg atattcaaga acgaccccta ccatccagac catttcaact      600

gcgccaactg cgggaaggag ctgactgccg atgcacggga gctgaaaggg gagctatact      660

gcctcccatg ccatgataaa atgggggtcc ccatctgtgg tgcttgccga cggcccatcg      720

aagggcgcgt ggtgaacgct atgggcaagc agtggcatgt ggagcatttt gtttgtgcca      780

agtgtgagaa accctttctt ggacatcgcc attatgagag gaaaggcctg gcatattgtg      840

aaactcacta taaccagcta tttggtgatg tttgcttcca ctgcaatcgt gttatagaag      900

gtgatgtggt ctctgctctt aataaggcct ggtgcgtgaa ctgctttgcc tgttctacct      960

gcaacactaa attaacactc aagaataagt ttgtggagtt tgacatgaag ccagtctgta     1020

agaagtgcta tgagaaattt ccattggagc tgaagaaaag acttaagaaa ctagctgaga     1080

ccttaggaag gaaataagtt cctttatttt ttcttttcta tgcaagataa gagattacca     1140

acattacttg tcttgatcta cccatattta aagctatatc tcaaagcagt tgagagaaga     1200

ggacctatat gaatggtttt atgtcatttt tttaaa                               1236


<210>  2
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  3
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  3
atgacgggaa gcaatatgtc ggacgccttg gccaacgccg tgtgccagcg ctgccaggcc       60

cgcttctccc ccgccgagcg cattgtcaac agcaatgggg agctgtacca tgagcactgc      120

ttcgtgtgtg cccagtgctt ccggcccttc cccgaggggc tcttctatga gtttgaaggc      180

cggaagtact gcgaacacga cttccaaatg ctgtttgctc cgtgctgtgg atcctgcggt      240

gagttcatca ttggccgcgt catcaaggcc atgaacaaca actggcaccc gggctgcttc      300

cgctgcgagc tgtgtgatgt ggagctggct gacctgggct ttgtgaagaa tgccggcagg      360

catctctgcc ggccttgcca caaccgtgag aaggccaaag gcctgggcaa gtacatctgc      420

cagcggtgcc acctggtcat cgacgagcag cccctcatgt tcaggagcga cgcctaccac      480

cctgaccact tcaactgcac ccactgtggg aaggagctga cagccgaggc ccgcgagctg      540

aagggtgagc tctactgcct gccctgccat gacaagatgg gcgtccccat ctgcggggcc      600

tgccgccggc ccatcgaggg ccgagtggtc aacgcgctgg gcaagcagtg gcacgtggag      660

cactttgtct gtgccaagtg tgagaagcca ttcctggggc accggcacta tgagaagaag      720

ggcctggcct actgcgagac tcactacaac cagctcttcg gggacgtctg ctacaactgc      780

agccatgtga ttgaaggcga tgtggtgtcg gccctcaaca aggcctggtg tgtgagctgc      840

ttctcctgct ccacctgcaa cagcaagctc accctgaagg acaagtttgt ggagttcgac      900

atgaagcccg tgtgtaagag gtgctacgag aagttcccgc tggagctgaa gaagcggctg      960

aagaagctgt cggagctgac ctcccgcaag gcccagccca aggccacaga cctcaactct     1020

gcctga                                                                1026


<210>  4
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Met Thr Gly Ser Asn Met Ser Asp Ala 
    130                 135                 140                 


Leu Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg Phe Ser Pro Ala 
145                 150                 155                 160 


Glu Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu His Cys Phe 
                165                 170                 175     


Val Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly Leu Phe Tyr Glu 
            180                 185                 190         


Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe Ala 
        195                 200                 205             


Pro Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly Arg Val Ile Lys 
    210                 215                 220                 


Ala Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu Cys 
225                 230                 235                 240 


Asp Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg His 
                245                 250                 255     


Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly Lys 
            260                 265                 270         


Tyr Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu Met 
        275                 280                 285             


Phe Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His Cys 
    290                 295                 300                 


Gly Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu Tyr 
305                 310                 315                 320 


Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala Cys 
                325                 330                 335     


Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln Trp 
            340                 345                 350         


His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu Gly 
        355                 360                 365             


His Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His Tyr 
    370                 375                 380                 


Asn Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile Glu 
385                 390                 395                 400 


Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys Phe 
                405                 410                 415     


Ser Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asp Lys Phe Val 
            420                 425                 430         


Glu Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe Pro 
        435                 440                 445             


Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser Arg 
    450                 455                 460                 


Lys Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
465                 470                 475     


