                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Production Cell Line Enhancers

<130>  8150A

<150>  US 61/652,549
<151>  2012-05-29

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  577
<212>  PRT
<213>  Mus musculus

<400>  1

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Val Cys Val Leu Leu 
1               5                   10                  15      


Pro Leu His His Gly Ala Pro Gly Pro Asp Gly Thr Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Tyr Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Thr Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Asn Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr His Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe His Pro Asn Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Ser Val Met Thr Pro His Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Arg Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Ile Lys Glu Phe Tyr Ser Leu Lys Gln Ser Arg 
            500                 505                 510         


Pro Lys Arg Ala Gln Arg Lys Thr Val Arg Ser Gly Pro Trp Glu Pro 
        515                 520                 525             


Gln Ser Gly Pro Ala Thr Leu Ser Ser Pro Ala Asn Gln Pro Arg Glu 
    530                 535                 540                 


Lys Gln Pro Ala Gln Gln Arg Thr Pro Leu Leu Ser Cys Pro Ser Gln 
545                 550                 555                 560 


Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp Ser 
                565                 570                 575     


Ser 
    


<210>  2
<211>  576
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Val Cys Val Leu Leu 
1               5                   10                  15      


Pro Leu His His Gly Ala Pro Gly Pro Glu Gly Thr Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Tyr Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Thr Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Asn Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr His Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe His Pro Asn Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Ser Val Met Thr Pro His Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Arg Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Ile Lys Glu Phe Tyr Ser Leu Arg Gln Ser Arg 
            500                 505                 510         


Ser Arg Ala Gln Arg Lys Thr Val Ser Ser Gly Pro Trp Glu Pro Pro 
        515                 520                 525             


Ala Gly Pro Gly Thr Leu Ser Ser Pro Glu Asn Gln Pro Arg Glu Lys 
    530                 535                 540                 


Gln Pro Ala Arg Gln Arg Ala Pro Leu Leu Ser Cys Pro Ser Gln Pro 
545                 550                 555                 560 


Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp Ser Ser 
                565                 570                 575     


<210>  3
<211>  578
<212>  PRT
<213>  Cricetulus griseus

<400>  3

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Val Cys Val Phe Leu 
1               5                   10                  15      


Pro Leu His His Gly Ala Pro Gly Pro Asp Gly Thr Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Tyr Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Thr Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Asn Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Leu Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Arg Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr His Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Ala Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe His Pro Asn Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Ser Val Met Thr Pro His Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Arg Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Met Arg Glu Leu His Ser Leu Lys Gln Ser Arg 
            500                 505                 510         


Ser Arg Ala Gln Arg Lys Thr Thr Ser Ser Gly Pro Trp Glu Pro Pro 
        515                 520                 525             


Ala Gly Pro Gly Ser Pro Ser Ala Pro Gly Lys Gln Asp Gln Pro Arg 
    530                 535                 540                 


Glu Lys Gln Pro Ala Lys Gln Arg Thr Pro Leu Leu Ser Cys Pro Ser 
545                 550                 555                 560 


Gln Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp 
                565                 570                 575     


Ser Ser 
        


<210>  4
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Leu Cys Ala Leu Leu 
1               5                   10                  15      


Pro Gln His His Gly Ala Pro Gly Pro Asp Gly Ser Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Phe Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Val Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Ser Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr Arg Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe Asp Pro Thr Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Thr Val Ile Thr Pro Tyr Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Gln Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Met Arg Glu Phe Tyr Ser Leu Lys Arg Ser Arg 
            500                 505                 510         


Ser Lys Phe Gln Lys Asn Thr Val Ser Ser Gly Pro Trp Glu Pro Pro 
        515                 520                 525             


Ala Arg Pro Gly Thr Leu Phe Ser Pro Glu Asn His Asp Gln Ala Arg 
    530                 535                 540                 


Glu Arg Lys Pro Ala Lys Gln Lys Val Pro Leu Leu Ser Cys Pro Ser 
545                 550                 555                 560 


Gln Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp 
                565                 570                 575     


Ser Ser 
        


<210>  5
<211>  578
<212>  PRT
<213>  Pan troglodytes

<400>  5

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Leu Cys Ala Leu Leu 
1               5                   10                  15      


Pro Leu His His Gly Ala Pro Gly Pro Asp Gly Ser Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Phe Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Val Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Ser Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr Arg Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe Asp Pro Thr Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Ala Val Ile Thr Pro Tyr Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Gln Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Met Arg Glu Phe Tyr Ser Leu Lys Arg Ser Arg 
            500                 505                 510         


Ser Lys Phe Gln Lys Lys Thr Val Ser Ser Gly Pro Trp Glu Pro Pro 
        515                 520                 525             


Ala Arg Pro Gly Thr Leu Phe Ser Pro Glu Asn His Asp Gln Ala Arg 
    530                 535                 540                 


Glu Arg Lys Pro Ala Lys Gln Lys Val Pro Leu Leu Ser Cys Pro Ser 
545                 550                 555                 560 


Gln Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp 
                565                 570                 575     


Ser Ser 
        


<210>  6
<211>  513
<212>  PRT
<213>  Pongo pygmaeus

<400>  6

Met Asn Thr Leu Ser Cys Ser Leu Phe Ser Leu Thr Leu Ile Asp Ala 
1               5                   10                  15      


Leu Asp Thr Leu Leu Ile Leu Gly Asn Val Ser Glu Phe Gln Arg Val 
            20                  25                  30          


Val Glu Val Leu Gln Asp Asn Val Asp Phe Asp Ile Asp Val Asn Ala 
        35                  40                  45              


Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser Ala 
    50                  55                  60                  


His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp Pro 
65                  70                  75                  80  


Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys Leu 
                85                  90                  95      


Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val Asn 
            100                 105                 110         


Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr Ala 
        115                 120                 125             


Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu Thr 
    130                 135                 140                 


Gly Asp Pro Val Phe Glu Asp Val Ala Arg Val Ala Leu Met Arg Leu 
145                 150                 155                 160 


Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp Val 
                165                 170                 175     


Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly Val 
            180                 185                 190         


Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln Asp 
        195                 200                 205             


Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Lys Ala Ile Arg Asn 
    210                 215                 220                 


Tyr Thr Arg Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys Gly 
225                 230                 235                 240 


Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro Gly 
                245                 250                 255     


Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe Leu 
            260                 265                 270         


Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe Tyr 
        275                 280                 285             


Asn Ile Pro Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro Leu 
    290                 295                 300                 


Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr Gly 
305                 310                 315                 320 


Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile Glu 
                325                 330                 335     


Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu Arg 
            340                 345                 350         


Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu Thr 
        355                 360                 365             


Val Lys Tyr Leu Tyr Leu Leu Phe Asp Pro Thr Asn Phe Ile His Asn 
    370                 375                 380                 


Asn Gly Ser Thr Phe Asp Ala Val Ile Thr Pro Tyr Gly Glu Cys Ile 
385                 390                 395                 400 


Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile Asp 
                405                 410                 415     


Pro Ala Ala Leu His Cys Cys Gln Arg Leu Lys Glu Glu Gln Trp Glu 
            420                 425                 430         


Val Glu Asp Leu Met Arg Glu Phe Tyr Ser Leu Lys Arg Asn Arg Ser 
        435                 440                 445             


Lys Phe Gln Lys Lys Thr Val Ser Ser Gly Pro Trp Glu Pro Pro Ala 
    450                 455                 460                 


Arg Pro Gly Thr Leu Phe Ser Pro Glu Asn His Asp Gln Ala Arg Gly 
465                 470                 475                 480 


Arg Lys Pro Ala Lys Gln Lys Val Pro Leu Leu Ser Cys Pro Ser Gln 
                485                 490                 495     


Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp Ser 
            500                 505                 510         


Ser 
    


<210>  7
<211>  572
<212>  PRT
<213>  Danio rerio

<400>  7

Leu Tyr Tyr Leu Pro Leu Phe Thr Ser Arg Tyr Phe Met Leu Thr Phe 
1               5                   10                  15      


Leu Phe Ser Ala Ile Phe Cys Ala Ala Tyr Leu Ser Pro Ile Ile Ser 
            20                  25                  30          


His Val Lys Gly Arg Asp Phe Thr Glu Gln Glu Met Ser His Tyr Arg 
        35                  40                  45              


Asp Arg Val Lys Ser Met Phe Tyr His Ala Tyr Asn Ser Tyr Leu Asp 
    50                  55                  60                  


Asn Ala Tyr Pro Tyr Asp Glu Leu Arg Pro Leu Thr Cys Asp Gly Gln 
65                  70                  75                  80  


Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp Ala Leu Asp Thr 
                85                  90                  95      


Leu Leu Ile Leu Gly Asn His Thr Glu Phe Gln Arg Val Ala Thr Leu 
            100                 105                 110         


Leu Gln Asp Thr Val Asp Phe Asp Ile Asp Val Asn Ala Ser Val Phe 
        115                 120                 125             


Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser Ala His Leu Leu 
    130                 135                 140                 


Ser Lys Arg Ala Gly Met Lys Val Glu Glu Gly Trp Pro Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Leu Arg Met Ala Glu Asp Ala Ala Arg Lys Leu Leu Pro Ala 
                165                 170                 175     


Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val Asn Leu Leu Arg 
            180                 185                 190         


Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr Ala Gly Val Gly 
        195                 200                 205             


Thr Phe Ile Leu Glu Phe Ser Thr Leu Ser Arg Leu Thr Gly Asp Pro 
    210                 215                 220                 


Val Phe Glu Asn Val Ala Arg Lys Ala Leu Arg Ala Leu Trp Arg Thr 
225                 230                 235                 240 


Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp Val Ile Thr Ser 
                245                 250                 255     


Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly Val Asp Ser Tyr 
            260                 265                 270         


Phe Glu Tyr Leu Val Arg Gly Ala Ile Met Leu Gln Asp Glu Glu Leu 
        275                 280                 285             


Leu Thr Met Phe Tyr Glu Phe Asp Lys Ser Ile Lys Asn Tyr Thr Lys 
    290                 295                 300                 


Phe Asp Asp Trp Tyr Leu Trp Val Gln Met His Lys Gly Thr Val Ser 
305                 310                 315                 320 


Met Pro Val Phe Gln Ser Leu Glu Ala Phe Trp Pro Gly Met Gln Ser 
                325                 330                 335     


Leu Ile Gly Asp Ile Ser Ser Ala Thr Lys Ser Phe His Asn Tyr Tyr 
            340                 345                 350         


Ser Val Trp Arg Gln Phe Gly Gly Leu Pro Glu Phe Tyr Ser Ile Pro 
        355                 360                 365             


Gln Gly Tyr Thr Val Asp Lys Arg Glu Gly Tyr Pro Leu Arg Pro Glu 
    370                 375                 380                 


Leu Ile Glu Ser Ala Met Tyr Leu Tyr Lys Ala Thr Gly Asp Pro Ser 
385                 390                 395                 400 


Phe Ile Gln Leu Gly Arg Asp Ala Val Glu Ser Ile Asp Arg Ile Ser 
                405                 410                 415     


Arg Val Asn Cys Gly Phe Ala Thr Val Lys Asp Val Arg Asp His Lys 
            420                 425                 430         


Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu Thr Ile Lys Tyr 
        435                 440                 445             


Leu Tyr Leu Leu Phe Asp Pro Asp Asn Phe Leu His Asn Thr Gly Thr 
    450                 455                 460                 


Glu Phe Glu Leu Gly Gly Leu Arg Gly Asp Cys Ile Leu Ser Ala Gly 
465                 470                 475                 480 


Gly Tyr Val Phe Asn Thr Glu Ala His Pro Leu Asp Pro Ala Ala Leu 
                485                 490                 495     


His Cys Cys Ser Arg Glu Gln Gln Asp Arg Arg Glu Ile Gln Asp Ile 
            500                 505                 510         


Leu Leu Ser Phe Ser Gln Pro His Thr Glu Glu Pro Ser Arg Asp Gln 
        515                 520                 525             


Ser Ala Gly Gly Ser Pro Glu Ser Ile Ala Leu Lys Pro Gly Glu Gln 
    530                 535                 540                 


Arg Lys Ala Pro Val Leu Ser Cys Pro Thr Gln Pro Phe Ser Ala Lys 
545                 550                 555                 560 


Leu Ala Val Met Gly Gln Val Phe Ser Asp Asn Ser 
                565                 570         


<210>  8
<211>  577
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  V or L

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  V or A

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  L or F

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Y or F

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  T or V

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  N or S

<220>
<221>  MISC_FEATURE
<222>  (220)..(220)
<223>  V or L

<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  H or R

<220>
<221>  MISC_FEATURE
<222>  (356)..(356)
<223>  P or A

<220>
<221>  MISC_FEATURE
<222>  (442)..(442)
<223>  H or D

<220>
<221>  MISC_FEATURE
<222>  (444)..(444)
<223>  N or T

<220>
<221>  MISC_FEATURE
<222>  (456)..(456)
<223>  S, T, or A

<220>
<221>  MISC_FEATURE
<222>  (458)..(458)
<223>  M or I

<220>
<221>  MISC_FEATURE
<222>  (461)..(461)
<223>  H or Y

<220>
<221>  MISC_FEATURE
<222>  (489)..(489)
<223>  R or Q

<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  I or M

<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (505)..(505)
<223>  F or L

<220>
<221>  MISC_FEATURE
<222>  (506)..(506)
<223>  Y or H

<220>
<221>  MISC_FEATURE
<222>  (509)..(509)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Q or R

<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  P or S

<220>
<221>  MISC_FEATURE
<222>  (514)..(516)
<223>  KRA, RA, or KF

<220>
<221>  MISC_FEATURE
<222>  (518)..(518)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (519)..(519)
<223>  K or N

<220>
<221>  MISC_FEATURE
<222>  (522)..(522)
<223>  R or S

<220>
<221>  MISC_FEATURE
<222>  (529)..(529)
<223>  Q or P

<220>
<221>  MISC_FEATURE
<222>  (530)..(530)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (531)..(531)
<223>  G or R

<220>
<221>  MISC_FEATURE
<222>  (533)..(533)
<223>  A or G

<220>
<221>  MISC_FEATURE
<222>  (534)..(534)
<223>  T or S

<220>
<221>  MISC_FEATURE
<222>  (535)..(535)
<223>  L or P

<220>
<221>  MISC_FEATURE
<222>  (536)..(536)
<223>  S or F

<220>
<221>  MISC_FEATURE
<222>  (537)..(537)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (539)..(540)
<223>  AN, EN, GKQD, or ENHD

<220>
<221>  MISC_FEATURE
<222>  (542)..(542)
<223>  P or A

<220>
<221>  MISC_FEATURE
<222>  (545)..(545)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (546)..(546)
<223>  Q or K

<220>
<221>  MISC_FEATURE
<222>  (549)..(549)
<223>  Q, R, or K

<220>
<221>  MISC_FEATURE
<222>  (551)..(551)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (552)..(552)
<223>  T, A, or V

<400>  8

Met Pro Phe Arg Leu Leu Ile Pro Leu Gly Leu Xaa Cys Xaa Xaa Leu 
1               5                   10                  15      


Pro Leu His His Gly Ala Pro Gly Pro Xaa Gly Xaa Ala Pro Asp Pro 
            20                  25                  30          


Ala His Tyr Arg Glu Arg Val Lys Ala Met Phe Tyr His Ala Tyr Asp 
        35                  40                  45              


Ser Tyr Leu Glu Asn Ala Phe Pro Xaa Asp Glu Leu Arg Pro Leu Thr 
    50                  55                  60                  


Cys Asp Gly His Asp Thr Trp Gly Ser Phe Ser Leu Thr Leu Ile Asp 
65                  70                  75                  80  


Ala Leu Asp Thr Leu Leu Ile Leu Gly Asn Xaa Ser Glu Phe Gln Arg 
                85                  90                  95      


Val Val Glu Val Leu Gln Asp Xaa Val Asp Phe Asp Ile Asp Val Asn 
            100                 105                 110         


Ala Ser Val Phe Glu Thr Asn Ile Arg Val Val Gly Gly Leu Leu Ser 
        115                 120                 125             


Ala His Leu Leu Ser Lys Lys Ala Gly Val Glu Val Glu Ala Gly Trp 
    130                 135                 140                 


Pro Cys Ser Gly Pro Leu Leu Arg Met Ala Glu Glu Ala Ala Arg Lys 
145                 150                 155                 160 


Leu Leu Pro Ala Phe Gln Thr Pro Thr Gly Met Pro Tyr Gly Thr Val 
                165                 170                 175     


Asn Leu Leu His Gly Val Asn Pro Gly Glu Thr Pro Val Thr Cys Thr 
            180                 185                 190         


Ala Gly Ile Gly Thr Phe Ile Val Glu Phe Ala Thr Leu Ser Ser Leu 
        195                 200                 205             


Thr Gly Asp Pro Val Phe Glu Asp Val Ala Arg Xaa Ala Leu Met Arg 
    210                 215                 220                 


Leu Trp Glu Ser Arg Ser Asp Ile Gly Leu Val Gly Asn His Ile Asp 
225                 230                 235                 240 


Val Leu Thr Gly Lys Trp Val Ala Gln Asp Ala Gly Ile Gly Ala Gly 
                245                 250                 255     


Val Asp Ser Tyr Phe Glu Tyr Leu Val Lys Gly Ala Ile Leu Leu Gln 
            260                 265                 270         


Asp Lys Lys Leu Met Ala Met Phe Leu Glu Tyr Asn Xaa Ala Ile Arg 
        275                 280                 285             


Asn Tyr Thr Xaa Phe Asp Asp Trp Tyr Leu Trp Val Gln Met Tyr Lys 
    290                 295                 300                 


Gly Thr Val Ser Met Pro Val Phe Gln Ser Leu Glu Ala Tyr Trp Pro 
305                 310                 315                 320 


Gly Leu Gln Ser Leu Ile Gly Asp Ile Asp Asn Ala Met Arg Thr Phe 
                325                 330                 335     


Leu Asn Tyr Tyr Thr Val Trp Lys Gln Phe Gly Gly Leu Pro Glu Phe 
            340                 345                 350         


Tyr Asn Ile Xaa Gln Gly Tyr Thr Val Glu Lys Arg Glu Gly Tyr Pro 
        355                 360                 365             


Leu Arg Pro Glu Leu Ile Glu Ser Ala Met Tyr Leu Tyr Arg Ala Thr 
    370                 375                 380                 


Gly Asp Pro Thr Leu Leu Glu Leu Gly Arg Asp Ala Val Glu Ser Ile 
385                 390                 395                 400 


Glu Lys Ile Ser Lys Val Glu Cys Gly Phe Ala Thr Ile Lys Asp Leu 
                405                 410                 415     


Arg Asp His Lys Leu Asp Asn Arg Met Glu Ser Phe Phe Leu Ala Glu 
            420                 425                 430         


Thr Val Lys Tyr Leu Tyr Leu Leu Phe Xaa Pro Xaa Asn Phe Ile His 
        435                 440                 445             


Asn Asn Gly Ser Thr Phe Asp Xaa Val Xaa Thr Pro Xaa Gly Glu Cys 
    450                 455                 460                 


Ile Leu Gly Ala Gly Gly Tyr Ile Phe Asn Thr Glu Ala His Pro Ile 
465                 470                 475                 480 


Asp Pro Ala Ala Leu His Cys Cys Xaa Arg Leu Lys Glu Glu Gln Trp 
                485                 490                 495     


Glu Val Glu Asp Leu Xaa Xaa Glu Xaa Xaa Ser Leu Xaa Xaa Ser Arg 
            500                 505                 510         


Xaa Xaa Xaa Xaa Gln Xaa Xaa Thr Val Xaa Ser Gly Pro Trp Glu Pro 
        515                 520                 525             


Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Gln Xaa Arg Glu 
    530                 535                 540                 


Xaa Xaa Pro Ala Xaa Gln Xaa Xaa Pro Leu Leu Ser Cys Pro Ser Gln 
545                 550                 555                 560 


Pro Phe Thr Ser Lys Leu Ala Leu Leu Gly Gln Val Phe Leu Asp Ser 
                565                 570                 575     


Ser 
    


<210>  9
<211>  371
<212>  PRT
<213>  Mus musculus

<400>  9

Met Val Val Val Ala Ala Ala Pro Ser Ala Ala Thr Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Gly Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Pro Arg Ala Ala Gly Ser Glu Ala Ser Gly Thr 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn His Lys Leu Gln Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Val Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asp Thr Leu Asp Pro Asp Glu Val Pro Glu Val Glu 
    130                 135                 140                 


Ala Lys Gly Ser Gly Val Arg Leu Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Gly Ala Gly Pro Val Val Thr Ser Pro Glu His Leu Pro Met Asp 
                165                 170                 175     


Ser Asp Thr Val Ala Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly 
            180                 185                 190         


Ile Leu Asp Lys Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro 
        195                 200                 205             


Glu Ser Ala Ser Leu Glu Glu Leu Pro Glu Val Tyr Pro Glu Gly Pro 
    210                 215                 220                 


Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala 
225                 230                 235                 240 


Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Val Tyr Thr 
                245                 250                 255     


Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln Thr Asn 
            260                 265                 270         


Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser Ser Ser Glu Glu Asp 
        275                 280                 285             


His Pro Glu Phe Ile Val Ser Val Lys Lys Glu Pro Leu Glu Asp Asp 
    290                 295                 300                 


Phe Ile Pro Glu Leu Gly Ile Ser Asn Leu Leu Ser Ser Ser His Cys 
305                 310                 315                 320 


Leu Arg Pro Pro Ser Cys Leu Leu Asp Ala His Ser Asp Cys Gly Tyr 
                325                 330                 335     


Glu Gly Ser Pro Ser Pro Phe Ser Asp Met Ser Ser Pro Leu Gly Thr 
            340                 345                 350         


Asp His Ser Trp Glu Asp Thr Phe Ala Asn Glu Leu Phe Pro Gln Leu 
        355                 360                 365             


Ile Ser Val 
    370     


<210>  10
<211>  369
<212>  PRT
<213>  Cricetulus griseus

<400>  10

Met Val Val Val Ala Ala Ser Pro Ser Ala Ala Thr Ala Ala Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ala Asp Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Gly Ser Arg Ala Ala Gly Ser Glu Ala Asn Gly Ala 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn Gln Lys Leu Leu Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Ile Glu Asn Gln Glu Leu Arg Thr 
        115                 120                 125             


Arg Leu Gly Met Asp Val Leu Thr Thr Glu Glu Ala Pro Glu Thr Glu 
    130                 135                 140                 


Ser Lys Gly Asn Gly Val Arg Pro Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Gly Ala Gly Pro Val Val Thr Ser Pro Glu His Leu Pro Met Asp 
                165                 170                 175     


Ser Asp Thr Val Asp Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly 
            180                 185                 190         


Ile Leu Asp Lys Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro 
        195                 200                 205             


Glu Ser Ala Asn Leu Glu Glu Leu Pro Glu Val Tyr Pro Gly Pro Ser 
    210                 215                 220                 


Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala Lys 
225                 230                 235                 240 


Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Val Tyr Thr Lys 
                245                 250                 255     


Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln Thr Asn Val 
            260                 265                 270         


Val Val Lys Ile Glu Glu Ala Pro Leu Ser Ser Ser Glu Glu Asp His 
        275                 280                 285             


Pro Glu Phe Ile Val Ser Val Lys Lys Glu Pro Glu Glu Asp Phe Ile 
    290                 295                 300                 


Pro Glu Pro Gly Ile Ser Asn Leu Leu Ser Ser Ser His Cys Leu Lys 
305                 310                 315                 320 


Pro Ser Ser Cys Leu Leu Asp Ala Tyr Ser Asp Cys Gly Tyr Glu Gly 
                325                 330                 335     


Ser Pro Ser Pro Phe Ser Asp Met Ser Ser Pro Leu Gly Ile Asp His 
            340                 345                 350         


Ser Trp Glu Asp Thr Phe Ala Asn Glu Leu Phe Pro Gln Leu Ile Ser 
        355                 360                 365             


Val 
    


<210>  11
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala 
            20                  25                  30          


Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro 
        35                  40                  45              


Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu 
    50                  55                  60                  


Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn 
65                  70                  75                  80  


Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser 
                85                  90                  95      


Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val 
        115                 120                 125             


Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala 
    130                 135                 140                 


Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly 
145                 150                 155                 160 


Ser Ala Glu Ser Ala Ala Gly Ala Gly Pro Val Val Thr Pro Pro Glu 
                165                 170                 175     


His Leu Pro Met Asp Ser Gly Gly Ile Asp Ser Ser Asp Ser Glu Ser 
            180                 185                 190         


Asp Ile Leu Leu Gly Ile Leu Asp Asn Leu Asp Pro Val Met Phe Phe 
        195                 200                 205             


Lys Cys Pro Ser Pro Glu Pro Ala Ser Leu Glu Glu Leu Pro Glu Val 
    210                 215                 220                 


Tyr Pro Glu Gly Pro Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val 
225                 230                 235                 240 


Gly Thr Ser Ser Ala Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe 
                245                 250                 255     


Asp His Ile Tyr Thr Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr 
            260                 265                 270         


Glu Ser Gln Ala Asn Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser 
        275                 280                 285             


Pro Ser Glu Asn Asp His Pro Glu Phe Ile Val Ser Val Lys Glu Glu 
    290                 295                 300                 


Pro Val Glu Asp Asp Leu Val Pro Glu Leu Gly Ile Ser Asn Leu Leu 
305                 310                 315                 320 


Ser Ser Ser His Cys Pro Lys Pro Ser Ser Cys Leu Leu Asp Ala Tyr 
                325                 330                 335     


Ser Asp Cys Gly Tyr Gly Gly Ser Leu Ser Pro Phe Ser Asp Met Ser 
            340                 345                 350         


Ser Leu Leu Gly Val Asn His Ser Trp Glu Asp Thr Phe Ala Asn Glu 
        355                 360                 365             


Leu Phe Pro Gln Leu Ile Ser Val 
    370                 375     


<210>  12
<211>  383
<212>  PRT
<213>  Danio rerio

<400>  12

Met Val Val Val Thr Ala Gly Thr Gly Gly Ala His Lys Val Leu Leu 
1               5                   10                  15      


Ile Ser Gly Lys Gln Ser Ala Ser Thr Gly Ala Thr Gln Gly Gly Tyr 
            20                  25                  30          


Ser Arg Ser Ile Ser Val Met Ile Pro Asn Gln Ala Ser Ser Asp Ser 
        35                  40                  45              


Asp Ser Thr Thr Ser Gly Pro Pro Leu Arg Lys Arg Gln Arg Leu Thr 
    50                  55                  60                  


His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg 
65                  70                  75                  80  


Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Lys Met Gly Glu 
                85                  90                  95      


Leu Glu Gln Gln Val Leu Glu Leu Glu Leu Glu Asn Gln Lys Leu His 
            100                 105                 110         


Val Glu Asn Arg Leu Leu Arg Asp Lys Thr Ser Asp Leu Leu Ser Glu 
        115                 120                 125             


Asn Glu Glu Leu Arg Gln Arg Leu Gly Leu Asp Thr Leu Glu Thr Lys 
    130                 135                 140                 


Glu Gln Val Gln Val Leu Glu Ser Ala Val Ser Asp Leu Gly Leu Val 
145                 150                 155                 160 


Thr Gly Ser Ser Glu Ser Ala Ala Gly Ala Gly Pro Ala Val Pro Lys 
                165                 170                 175     


Ser Glu Asp Phe Thr Met Asp Thr His Ser Pro Gly Pro Ala Asp Ser 
            180                 185                 190         


Glu Ser Asp Leu Leu Leu Gly Ile Leu Asp Ile Leu Asp Pro Glu Leu 
        195                 200                 205             


Phe Leu Lys Thr Asp Leu Pro Glu Ala Gln Glu Pro Gln Gln Glu Leu 
    210                 215                 220                 


Val Leu Val Gly Gly Ala Gly Glu Gln Val Pro Ser Ser Ala Pro Ala 
225                 230                 235                 240 


Ala Leu Gly Pro Ala Pro Val Lys Leu Glu Ala Leu Asn Glu Leu Ile 
                245                 250                 255     


His Phe Asp His Ile Tyr Thr Lys Pro Ala Glu Val Leu Val Ser Glu 
            260                 265                 270         


Glu Ser Ile Cys Glu Val Lys Ala Glu Asp Ser Val Ala Phe Ser Glu 
        275                 280                 285             


Thr Glu Glu Glu Ile Gln Val Glu Asp Gln Thr Val Ser Val Lys Asp 
    290                 295                 300                 


Glu Pro Glu Glu Val Val Ile Pro Ala Glu Asn Gln Asn Pro Asp Ala 
305                 310                 315                 320 


Ala Asp Asp Phe Leu Ser Asp Thr Ser Phe Gly Gly Tyr Glu Lys Ala 
                325                 330                 335     


Ser Tyr Leu Thr Asp Ala Tyr Ser Asp Ser Gly Tyr Glu Arg Ser Pro 
            340                 345                 350         


Ser Pro Phe Ser Asn Ile Ser Ser Pro Leu Cys Ser Glu Gly Ser Trp 
        355                 360                 365             


Asp Asp Met Phe Ala Ser Glu Leu Phe Pro Gln Leu Ile Ser Val 
    370                 375                 380             


<210>  13
<211>  371
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  A or P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  T or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  A or G

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  S or A

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  R or Q

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  G or A

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  A or G

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  S or N, or ASG

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  T, A, or L

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  H or Q

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Q or L

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  T or Q

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  T, V, or A

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  D, T, or V

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  P, T, or A

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (140)..(140)
<223>  V, A, or none

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  P or none

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  V, T, or A

<220>
<221>  MISC_FEATURE
<222>  (145)..(145)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (149)..(149)
<223>  G or E

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  L or P

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  S or P

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  D or G

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  T or G

<220>
<221>  MISC_FEATURE
<222>  (180)..(180)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  A or D

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  K or N

<220>
<221>  MISC_FEATURE
<222>  (210)..(210)
<223>  S or P

<220>
<221>  MISC_FEATURE
<222>  (212)..(212)
<223>  S or N

<220>
<221>  MISC_FEATURE
<222>  (222)..(222)
<223>  E or none

<220>
<221>  MISC_FEATURE
<222>  (254)..(254)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (271)..(271)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (284)..(284)
<223>  S or P

<220>
<221>  MISC_FEATURE
<222>  (287)..(287)
<223>  E or N

<220>
<221>  MISC_FEATURE
<222>  (298)..(298)
<223>  K or E

<220>
<221>  MISC_FEATURE
<222>  (301)..(301)
<223>  L, V, or none

<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  D or E

<220>
<221>  MISC_FEATURE
<222>  (305)..(305)
<223>  F or L

<220>
<221>  MISC_FEATURE
<222>  (306)..(306)
<223>  I or V

<220>
<221>  MISC_FEATURE
<222>  (309)..(309)
<223>  L or P

<220>
<221>  MISC_FEATURE
<222>  (321)..(321)
<223>  L or P

<220>
<221>  MISC_FEATURE
<222>  (322)..(322)
<223>  R or K

<220>
<221>  MISC_FEATURE
<222>  (324)..(324)
<223>  P or S

<220>
<221>  MISC_FEATURE
<222>  (331)..(331)
<223>  H or Y

<220>
<221>  MISC_FEATURE
<222>  (337)..(337)
<223>  E or G

<220>
<221>  MISC_FEATURE
<222>  (340)..(340)
<223>  P or L

<220>
<221>  MISC_FEATURE
<222>  (349)..(349)
<223>  P or L

<220>
<221>  MISC_FEATURE
<222>  (352)..(352)
<223>  T, I, or V

<220>
<221>  MISC_FEATURE
<222>  (353)..(353)
<223>  D or N

<400>  13

Met Val Val Val Ala Ala Xaa Pro Xaa Xaa Ala Xaa Xaa Xaa Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Xaa Xaa Gly Arg Ala Leu Pro 
            20                  25                  30          


Leu Met Val Pro Xaa Xaa Arg Xaa Ala Gly Ser Glu Ala Xaa Gly Xaa 
        35                  40                  45              


Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu 
    50                  55                  60                  


Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg Val Ala Ala Gln Thr Ala 
65                  70                  75                  80  


Arg Asp Arg Lys Lys Ala Arg Met Ser Glu Leu Glu Gln Gln Val Val 
                85                  90                  95      


Asp Leu Glu Glu Glu Asn Xaa Lys Leu Xaa Leu Glu Asn Gln Leu Leu 
            100                 105                 110         


Arg Glu Lys Thr His Gly Leu Val Xaa Glu Asn Gln Glu Leu Arg Xaa 
        115                 120                 125             


Arg Leu Gly Met Asp Xaa Leu Asp Xaa Xaa Glu Xaa Xaa Glu Xaa Glu 
    130                 135                 140                 


Xaa Lys Gly Xaa Xaa Val Arg Xaa Val Ala Gly Ser Ala Glu Ser Ala 
145                 150                 155                 160 


Ala Gly Ala Gly Pro Val Val Thr Xaa Pro Glu His Leu Pro Met Asp 
                165                 170                 175     


Ser Xaa Xaa Xaa Xaa Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly 
            180                 185                 190         


Ile Leu Asp Xaa Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro 
        195                 200                 205             


Glu Xaa Ala Xaa Leu Glu Glu Leu Pro Glu Val Tyr Pro Xaa Gly Pro 
    210                 215                 220                 


Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala 
225                 230                 235                 240 


Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Xaa Tyr Thr 
                245                 250                 255     


Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln Xaa Asn 
            260                 265                 270         


Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser Xaa Ser Glu Xaa Asp 
        275                 280                 285             


His Pro Glu Phe Ile Val Ser Val Lys Xaa Glu Pro Xaa Glu Xaa Asp 
    290                 295                 300                 


Xaa Xaa Pro Glu Xaa Gly Ile Ser Asn Leu Leu Ser Ser Ser His Cys 
305                 310                 315                 320 


Xaa Xaa Pro Xaa Ser Cys Leu Leu Asp Ala Xaa Ser Asp Cys Gly Tyr 
                325                 330                 335     


Xaa Gly Ser Xaa Ser Pro Phe Ser Asp Met Ser Ser Xaa Leu Gly Xaa 
            340                 345                 350         


Xaa His Ser Trp Glu Asp Thr Phe Ala Asn Glu Leu Phe Pro Gln Leu 
        355                 360                 365             


Ile Ser Val 
    370     


<210>  14
<211>  7686
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  14
aagcttatac tcgagctcta gattgggaac ccgggtctct cgaattcgat gccttttaga       60

ctcctgatac cattgggtct tgtttgcgtt ctcctccctc tccatcacgg cgccccaggt      120

ccagacggta ccgcacctga tcctgcccat taccgcgaac gcgttaaagc catgttctac      180

cacgcctatg actcctatct ggaaaatgca ttcccctatg atgagctccg accccttacc      240

tgcgatggtc atgatacttg gggctctttt tcccttaccc ttattgacgc tctggacaca      300

ctccttatcc tcggaaacac cagcgaattt caaagagtag ttgaagtact tcaggacaat      360

gtcgactttg acatcgatgt gaacgcatca gttttcgaaa caaatataag agtcgttgga      420

ggtctgctct ccgcccacct tctctctaaa aaagccggag tagaagttga agctggctgg      480

ccctgctccg gacccctcct tcgtatggct gaagaagctg cccgcaaact ccttcccgct      540

tttcagaccc caaccggtat gccctatggt actgttaacc tcctgcacgg agtaaatccc      600

ggcgaaaccc ccgtcacatg tacagccgga attggaacct ttattgtgga atttgcaacc      660

cttagcagcc tgaccggaga tcctgtattc gaagacgtgg ctcgggttgc cctgatgcga      720

ctgtgggaat ccaggtctga tatcggtctg gtcggtaacc atatagacgt actcactggt      780

aaatgggttg cacaagacgc tggaattggg gcaggcgtgg attcttattt tgaatatctc      840

gtaaaagggg ccatactctt gcaggacaaa aaacttatgg ctatgttcct ggaatataac      900

aaagctatta ggaactacac acacttcgat gattggtatt tgtgggtcca aatgtataaa      960

ggaaccgttt ctatgcctgt ctttcagtca ctggaggctt attggcctgg tctgcaatcc     1020

ctgatcggag acattgacaa tgcaatgagg acattcctta attattacac tgtttggaag     1080

cagttcggcg gattgcccga attttacaac attcctcaag gctatacagt tgaaaaaaga     1140

gaaggatatc ccctgcgccc cgagcttatt gaaagcgcta tgtatctgta tcgtgcaaca     1200

ggtgatccaa ccctgcttga actgggacga gacgccgtcg aatcaatcga gaaaatttca     1260

aaagtggaat gcggctttgc aacaattaaa gatcttagag accacaaact ggataatcgc     1320

atggagtcat tctttttggc tgagaccgtc aagtatctgt atctgctttt tcatcccaac     1380

aacttcatcc ataataacgg gtccaccttc gattcagtca tgacccctca cggtgaatgc     1440

atactcggag ctggaggcta tatttttaac actgaagctc acccaattga cccagctgcc     1500

cttcattgtt gtcgacgtct gaaagaagaa caatgggagg ttgaagattt gatcaaagaa     1560

ttttactcac ttaaacaaag tcgacctaaa cgcgcacaga gaaaaactgt aagatctggt     1620

ccttgggaac ctcagtccgg cccagcaact ctttcatccc ccgccaacca accacgagaa     1680

aaacaaccag cccaacagag aacccccctg ctcagctgcc cctctcagcc cttcacttca     1740

aaactcgccc tgcttggaca ggtgtttctg gactcctctt gatttaaaca cgcggccgct     1800

aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc     1860

cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta     1920

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     1980

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct accggtaggg     2040

cccctctctt catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     2100

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2160

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2220

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2280

cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg     2340

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2400

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2460

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2520

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     2580

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     2640

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     2700

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     2760

ggattttggt catgggcgcg cctcatactc ctgcaggcat gagattatca aaaaggatct     2820

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     2880

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     2940

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     3000

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     3060

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     3120

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     3180

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     3240

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     3300

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     3360

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     3420

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     3480

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     3540

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     3600

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     3660

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     3720

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     3780

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     3840

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtcaggtacc     3900

aagcctaggc ctccaaaaaa gcctcctcac tacttctgga atagctcaga ggcagaggcg     3960

gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga atgggcggaa     4020

ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt tgctgactaa     4080

ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt tccacacctg     4140

gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga gcctggggac     4200

tttccacacc ggatccacca tgggatcggc cattgaacaa gatggattgc acgcaggttc     4260

tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg     4320

ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac     4380

cgacctgtcc ggtgccctga atgaactgca ggacgaggca gcgcggctat cgtggctggc     4440

cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg     4500

gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga     4560

gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg     4620

cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg     4680

tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt     4740

cgccaggctc aaggcgcgca tgcccgacgg cgatgatctc gtcgtgaccc atggcgatgc     4800

ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg     4860

gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga     4920

gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc     4980

gcagcgcatc gccttctatc gccttcttga cgagttcttc tgaacgcgtg ctgtaagtct     5040

gcagaaattg atgatctatt aaacaataaa gatgtccact aaaatggaag tttttcctgt     5100

catactttgt taagaagggt gagaacagag tacctacatt ttgaatggaa ggattggagc     5160

tacgggggtg ggggtggggt gggattagat aaatgcctgc tctttactga aggctcttta     5220

ctattgcttt atgataatgt ttcatagttg gatatcataa tttaaacaag caaaaccaaa     5280

ttaagggcca gctcattcct cccactcatg atctatggat ctatagatct ctcgtgcagc     5340

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     5400

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     5460

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     5520

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     5580

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     5640

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     5700

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     5760

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagtcg     5820

cgaggcctcc gcgccgggtt ttggcgcctc ccgcgggcgc ccccctcctc acggcgagcg     5880

ctgccacgtc agacgaaggg cgcagcgagc gtcctgatcc ttccgcccgg acgctcagga     5940

cagcggcccg ctgctcataa gactcggcct tagaacccca gtatcagcag aaggacattt     6000

taggacggga cttgggtgac tctagggcac tggttttctt tccagagagc ggaacaggcg     6060

aggaaaagta gtcccttctc ggcgattctg cggagggatc tccgtggggc ggtgaacgcc     6120

gatgattata taaggacgcg ccgggtgtgg cacagctagt tccgtcgcag ccgggatttg     6180

ggtcgcggtt cttgtttgtg gatcgctgtg atcgtcactt ggtgagtagc gggctgctgg     6240

gctggccggg gctttcgtgg ccgccgggcc gctcggtggg acggaagcgt gtggagagac     6300

cgccaagggc tgtagtctgg gtccgcgagc aaggttgccc tgaactgggg gttgggggga     6360

gcgcagcaaa atggcggctg ttcccgagtc ttgaatggaa gacgcttgtg aggcgggctg     6420

tgaggtcgtt gaaacaaggt ggggggcatg gtgggcggca agaacccaag gtcttgaggc     6480

cttcgctaat gcgggaaagc tcttattcgg gtgagatggg ctggggcacc atctggggac     6540

cctgacgtga agtttgtcac tgactggaga actcggtttg tcgtctgttg cgggggcggc     6600

agttatggcg gtgccgttgg gcagtgcacc cgtacctttg ggagcgcgcg ccctcgtcgt     6660

gtcgtgacgt cacccgttct gttggcttat aatgcagggt ggggccacct gccggtaggt     6720

gtgcggtagg cttttctccg tcgcaggacg cagggttcgg gcctagggta ggctctcctg     6780

aatcgacagg cgccggacct ctggtgaggg gagggataag tgaggcgtca gtttctttgg     6840

tcggttttat gtacctatct tcttaagtag ctgaagctcc ggttttgaac tatgcgctcg     6900

gggttggcga gtgtgttttg tgaagttttt taggcacctt ttgaaatgta atcatttggg     6960

tcaatatgta attttcagtg ttagactagt aaattgtccg ctaaattctg gccgtttttg     7020

gcttttttgt tagacgtcga ccgatcctga gaacttcagg gtgagtttgg ggacccttga     7080

ttgttctttc tttttcgcta ttgtaaaatt catgttatat ggagggggca aagttttcag     7140

ggtgttgttt agaatgggaa gatgtccctt gtatcaccat ggaccctcat gataattttg     7200

tttctttcac tttctactct gttgacaacc attgtctcct cttattttct tttcattttc     7260

tgtaactttt tcgttaaact ttagcttgca tttgtaacga atttttaaat tcacttttgt     7320

ttatttgtca gattgtaagt actttctcta atcacttttt tttcaaggca atcagggtat     7380

attatattgt acttcagcac agttttagag aacaattgtt ataattaaat gataaggtag     7440

aatatttctg catataaatt ctggctggcg tggaaatatt cttattggta gaaacaacta     7500

caccctggtc atcatcctgc ctttctcttt atggttacaa tgatatacac tgtttgagat     7560

gaggataaaa tactctgagt ccaaaccggg cccctctgct aaccatgttc atgccttctt     7620

ctctttccta cagctcctgg gcaacgtgct ggttgttgtg ctgtctcatc attttggcaa     7680

agaatt                                                                7686


<210>  15
<211>  7257
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  15
aagcttatac tcgagctcta gattgggaac ccgggtctct cgaattcgat gccttttaga       60

ctcctgatac cattgggtct tgtttgcgtt ctcctccctc tccatcacgg cgccccaggt      120

ccagacggta ccgcacctga tcctgcccat taccgcgaac gcgttaaagc catgttctac      180

cacgcctatg actcctatct ggaaaatgca ttcccctatg atgagctccg accccttacc      240

tgcgatggtc atgatacttg gggctctttt tcccttaccc ttattgacgc tctggacaca      300

ctccttatcc tcggaaacac cagcgaattt caaagagtag ttgaagtact tcaggacaat      360

gtcgactttg acatcgatgt gaacgcatca gttttcgaaa caaatataag agtcgttgga      420

ggtctgctct ccgcccacct tctctctaaa aaagccggag tagaagttga agctggctgg      480

ccctgctccg gacccctcct tcgtatggct gaagaagctg cccgcaaact ccttcccgct      540

tttcagaccc caaccggtat gccctatggt actgttaacc tcctgcacgg agtaaatccc      600

ggcgaaaccc ccgtcacatg tacagccgga attggaacct ttattgtgga atttgcaacc      660

cttagcagcc tgaccggaga tcctgtattc gaagacgtgg ctcgggttgc cctgatgcga      720

ctgtgggaat ccaggtctga tatcggtctg gtcggtaacc atatagacgt actcactggt      780

aaatgggttg cacaagacgc tggaattggg gcaggcgtgg attcttattt tgaatatctc      840

gtaaaagggg ccatactctt gcaggacaaa aaacttatgg ctatgttcct ggaatataac      900

aaagctatta ggaactacac acacttcgat gattggtatt tgtgggtcca aatgtataaa      960

ggaaccgttt ctatgcctgt ctttcagtca ctggaggctt attggcctgg tctgcaatcc     1020

ctgatcggag acattgacaa tgcaatgagg acattcctta attattacac tgtttggaag     1080

cagttcggcg gattgcccga attttacaac attcctcaag gctatacagt tgaaaaaaga     1140

gaaggatatc ccctgcgccc cgagcttatt gaaagcgcta tgtatctgta tcgtgcaaca     1200

ggtgatccaa ccctgcttga actgggacga gacgccgtcg aatcaatcga gaaaatttca     1260

aaagtggaat gcggctttgc aacaattaaa gatcttagag accacaaact ggataatcgc     1320

atggagtcat tctttttggc tgagaccgtc aagtatctgt atctgctttt tcatcccaac     1380

aacttcatcc ataataacgg gtccaccttc gattcagtca tgacccctca cggtgaatgc     1440

atactcggag ctggaggcta tatttttaac actgaagctc acccaattga cccagctgcc     1500

cttcattgtt gtcgacgtct gaaagaagaa caatgggagg ttgaagattt gatcaaagaa     1560

ttttactcac ttaaacaaag tcgacctaaa cgcgcacaga gaaaaactgt aagatctggt     1620

ccttgggaac ctcagtccgg cccagcaact ctttcatccc ccgccaacca accacgagaa     1680

aaacaaccag cccaacagag aacccccctg ctcagctgcc cctctcagcc cttcacttca     1740

aaactcgccc tgcttggaca ggtgtttctg gactcctctt gatttaaaca cgcggccgct     1800

aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc     1860

cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta     1920

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     1980

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct accggtaggg     2040

cccctctctt catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     2100

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2160

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2220

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2280

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     2340

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2400

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2460

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2520

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     2580

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     2640

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     2700

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     2760

ggattttggt catgggcgcg cctcatactc ctgcaggcat gagattatca aaaaggatct     2820

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     2880

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     2940

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     3000

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     3060

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     3120

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     3180

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     3240

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     3300

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     3360

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     3420

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     3480

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     3540

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     3600

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     3660

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     3720

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     3780

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     3840

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtcaggtacc     3900

aagcctaggc ctccaaaaaa gcctcctcac tacttctgga atagctcaga ggcagaggcg     3960

gcctcggcct ctgcataaat aaaaaaaatt agtcagccat ggggcggaga atgggcggaa     4020

ctgggcggag ttaggggcgg gatgggcgga gttaggggcg ggactatggt tgctgactaa     4080

ttgagatgca tgctttgcat acttctgcct gctggggagc ctggggactt tccacacctg     4140

gttgctgact aattgagatg catgctttgc atacttctgc ctgctgggga gcctggggac     4200

tttccacacc ggatccacca tggccaagtt gaccagtgcc gttccggtgc tcaccgcgcg     4260

cgacgtcgcc ggagcggtcg agttctggac cgaccggctc gggttctccc gggacttcgt     4320

ggaggacgac ttcgccggtg tggtccggga cgacgtgacc ctgttcatca gcgcggtcca     4380

ggaccaggtg gtgccggaca acaccctggc ctgggtgtgg gtgcgcggcc tggacgagct     4440

gtacgccgag tggtcggagg tcgtgtccac gaacttccgg gacgcctccg ggccggccat     4500

gaccgagatc ggcgagcagc cgtgggggcg ggagttcgcc ctgcgcgacc cggccggcaa     4560

ctgcgtgcac ttcgtggccg aggagcagga ctgaacgcgt gctgtaagtc tgcagaaatt     4620

gatgatctat taaacaataa agatgtccac taaaatggaa gtttttcctg tcatactttg     4680

ttaagaaggg tgagaacaga gtacctacat tttgaatgga aggattggag ctacgggggt     4740

gggggtgggg tgggattaga taaatgcctg ctctttactg aaggctcttt actattgctt     4800

tatgataatg tttcatagtt ggatatcata atttaaacaa gcaaaaccaa attaagggcc     4860

agctcattcc tcccactcat gatctatgga tctatagatc tctcgtgcag ctggggctct     4920

agggggtatc cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     4980

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     5040

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     5100

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     5160

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     5220

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     5280

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     5340

taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg tcagttagtc gcgaggcctc     5400

cgcgccgggt tttggcgcct cccgcgggcg cccccctcct cacggcgagc gctgccacgt     5460

cagacgaagg gcgcagcgag cgtcctgatc cttccgcccg gacgctcagg acagcggccc     5520

gctgctcata agactcggcc ttagaacccc agtatcagca gaaggacatt ttaggacggg     5580

acttgggtga ctctagggca ctggttttct ttccagagag cggaacaggc gaggaaaagt     5640

agtcccttct cggcgattct gcggagggat ctccgtgggg cggtgaacgc cgatgattat     5700

ataaggacgc gccgggtgtg gcacagctag ttccgtcgca gccgggattt gggtcgcggt     5760

tcttgtttgt ggatcgctgt gatcgtcact tggtgagtag cgggctgctg ggctggccgg     5820

ggctttcgtg gccgccgggc cgctcggtgg gacggaagcg tgtggagaga ccgccaaggg     5880

ctgtagtctg ggtccgcgag caaggttgcc ctgaactggg ggttgggggg agcgcagcaa     5940

aatggcggct gttcccgagt cttgaatgga agacgcttgt gaggcgggct gtgaggtcgt     6000

tgaaacaagg tggggggcat ggtgggcggc aagaacccaa ggtcttgagg ccttcgctaa     6060

tgcgggaaag ctcttattcg ggtgagatgg gctggggcac catctgggga ccctgacgtg     6120

aagtttgtca ctgactggag aactcggttt gtcgtctgtt gcgggggcgg cagttatggc     6180

ggtgccgttg ggcagtgcac ccgtaccttt gggagcgcgc gccctcgtcg tgtcgtgacg     6240

tcacccgttc tgttggctta taatgcaggg tggggccacc tgccggtagg tgtgcggtag     6300

gcttttctcc gtcgcaggac gcagggttcg ggcctagggt aggctctcct gaatcgacag     6360

gcgccggacc tctggtgagg ggagggataa gtgaggcgtc agtttctttg gtcggtttta     6420

tgtacctatc ttcttaagta gctgaagctc cggttttgaa ctatgcgctc ggggttggcg     6480

agtgtgtttt gtgaagtttt ttaggcacct tttgaaatgt aatcatttgg gtcaatatgt     6540

aattttcagt gttagactag taaattgtcc gctaaattct ggccgttttt ggcttttttg     6600

ttagacgtcg accgatcctg agaacttcag ggtgagtttg gggacccttg attgttcttt     6660

ctttttcgct attgtaaaat tcatgttata tggagggggc aaagttttca gggtgttgtt     6720

tagaatggga agatgtccct tgtatcacca tggaccctca tgataatttt gtttctttca     6780

ctttctactc tgttgacaac cattgtctcc tcttattttc ttttcatttt ctgtaacttt     6840

ttcgttaaac tttagcttgc atttgtaacg aatttttaaa ttcacttttg tttatttgtc     6900

agattgtaag tactttctct aatcactttt ttttcaaggc aatcagggta tattatattg     6960

tacttcagca cagttttaga gaacaattgt tataattaaa tgataaggta gaatatttct     7020

gcatataaat tctggctggc gtggaaatat tcttattggt agaaacaact acaccctggt     7080

catcatcctg cctttctctt tatggttaca atgatataca ctgtttgaga tgaggataaa     7140

atactctgag tccaaaccgg gcccctctgc taaccatgtt catgccttct tctctttcct     7200

acagctcctg ggcaacgtgc tggttgttgt gctgtctcat cattttggca aagaatt        7257


<210>  16
<211>  3892
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16
aggcctccgc gccgggtttt ggcgcctccc gcgggcgccc ccctcctcac ggcgagcgct       60

gccacgtcag acgaagggcg cagcgagcgt cctgatcctt ccgcccggac gctcaggaca      120

gcggcccgct gctcataaga ctcggcctta gaaccccagt atcagcagaa ggacatttta      180

ggacgggact tgggtgactc tagggcactg gttttctttc cagagagcgg aacaggcgag      240

gaaaagtagt cccttctcgg cgattctgcg gagggatctc cgtggggcgg tgaacgccga      300

tgattatata aggacgcgcc gggtgtggca cagctagttc cgtcgcagcc gggatttggg      360

tcgcggttct tgtttgtgga tcgctgtgat cgtcacttgg tgagtagcgg gctgctgggc      420

tggccggggc tttcgtggcc gccgggccgc tcggtgggac ggaagcgtgt ggagagaccg      480

ccaagggctg tagtctgggt ccgcgagcaa ggttgccctg aactgggggt tggggggagc      540

gcagcaaaat ggcggctgtt cccgagtctt gaatggaaga cgcttgtgag gcgggctgtg      600

aggtcgttga aacaaggtgg ggggcatggt gggcggcaag aacccaaggt cttgaggcct      660

tcgctaatgc gggaaagctc ttattcgggt gagatgggct ggggcaccat ctggggaccc      720

tgacgtgaag tttgtcactg actggagaac tcggtttgtc gtctgttgcg ggggcggcag      780

ttatggcggt gccgttgggc agtgcacccg tacctttggg agcgcgcgcc ctcgtcgtgt      840

cgtgacgtca cccgttctgt tggcttataa tgcagggtgg ggccacctgc cggtaggtgt      900

gcggtaggct tttctccgtc gcaggacgca gggttcgggc ctagggtagg ctctcctgaa      960

tcgacaggcg ccggacctct ggtgagggga gggataagtg aggcgtcagt ttctttggtc     1020

ggttttatgt acctatcttc ttaagtagct gaagctccgg ttttgaacta tgcgctcggg     1080

gttggcgagt gtgttttgtg aagtttttta ggcacctttt gaaatgtaat catttgggtc     1140

aatatgtaat tttcagtgtt agactagtaa attgtccgct aaattctggc cgtttttggc     1200

ttttttgtta gacgtcgacc gatcctgaga acttcagggt gagtttgggg acccttgatt     1260

gttctttctt tttcgctatt gtaaaattca tgttatatgg agggggcaaa gttttcaggg     1320

tgttgtttag aatgggaaga tgtcccttgt atcaccatgg accctcatga taattttgtt     1380

tctttcactt tctactctgt tgacaaccat tgtctcctct tattttcttt tcattttctg     1440

taactttttc gttaaacttt agcttgcatt tgtaacgaat ttttaaattc acttttgttt     1500

atttgtcaga ttgtaagtac tttctctaat cacttttttt tcaaggcaat cagggtatat     1560

tatattgtac ttcagcacag ttttagagaa caattgttat aattaaatga taaggtagaa     1620

tatttctgca tataaattct ggctggcgtg gaaatattct tattggtaga aacaactaca     1680

ccctggtcat catcctgcct ttctctttat ggttacaatg atatacactg tttgagatga     1740

ggataaaata ctctgagtcc aaaccgggcc cctctgctaa ccatgttcat gccttcttct     1800

ctttcctaca gctcctgggc aacgtgctgg ttgttgtgct gtctcatcat tttggcaaag     1860

aattaagctt atactcgagc tctagattgg gaacccgggt ctctcgaatt cgatgccttt     1920

tagactcctg ataccattgg gtcttgtttg cgttctcctc cctctccatc acggcgcccc     1980

aggtccagac ggtaccgcac ctgatcctgc ccattaccgc gaacgcgtta aagccatgtt     2040

ctaccacgcc tatgactcct atctggaaaa tgcattcccc tatgatgagc tccgacccct     2100

tacctgcgat ggtcatgata cttggggctc tttttccctt acccttattg acgctctgga     2160

cacactcctt atcctcggaa acaccagcga atttcaaaga gtagttgaag tacttcagga     2220

caatgtcgac tttgacatcg atgtgaacgc atcagttttc gaaacaaata taagagtcgt     2280

tggaggtctg ctctccgccc accttctctc taaaaaagcc ggagtagaag ttgaagctgg     2340

ctggccctgc tccggacccc tccttcgtat ggctgaagaa gctgcccgca aactccttcc     2400

cgcttttcag accccaaccg gtatgcccta tggtactgtt aacctcctgc acggagtaaa     2460

tcccggcgaa acccccgtca catgtacagc cggaattgga acctttattg tggaatttgc     2520

aacccttagc agcctgaccg gagatcctgt attcgaagac gtggctcggg ttgccctgat     2580

gcgactgtgg gaatccaggt ctgatatcgg tctggtcggt aaccatatag acgtactcac     2640

tggtaaatgg gttgcacaag acgctggaat tggggcaggc gtggattctt attttgaata     2700

tctcgtaaaa ggggccatac tcttgcagga caaaaaactt atggctatgt tcctggaata     2760

taacaaagct attaggaact acacacactt cgatgattgg tatttgtggg tccaaatgta     2820

taaaggaacc gtttctatgc ctgtctttca gtcactggag gcttattggc ctggtctgca     2880

atccctgatc ggagacattg acaatgcaat gaggacattc cttaattatt acactgtttg     2940

gaagcagttc ggcggattgc ccgaatttta caacattcct caaggctata cagttgaaaa     3000

aagagaagga tatcccctgc gccccgagct tattgaaagc gctatgtatc tgtatcgtgc     3060

aacaggtgat ccaaccctgc ttgaactggg acgagacgcc gtcgaatcaa tcgagaaaat     3120

ttcaaaagtg gaatgcggct ttgcaacaat taaagatctt agagaccaca aactggataa     3180

tcgcatggag tcattctttt tggctgagac cgtcaagtat ctgtatctgc tttttcatcc     3240

caacaacttc atccataata acgggtccac cttcgattca gtcatgaccc ctcacggtga     3300

atgcatactc ggagctggag gctatatttt taacactgaa gctcacccaa ttgacccagc     3360

tgcccttcat tgttgtcgac gtctgaaaga agaacaatgg gaggttgaag atttgatcaa     3420

agaattttac tcacttaaac aaagtcgacc taaacgcgca cagagaaaaa ctgtaagatc     3480

tggtccttgg gaacctcagt ccggcccagc aactctttca tcccccgcca accaaccacg     3540

agaaaaacaa ccagcccaac agagaacccc cctgctcagc tgcccctctc agcccttcac     3600

ttcaaaactc gccctgcttg gacaggtgtt tctggactcc tcttgattta aacacgcggc     3660

cgctaatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc     3720

tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag     3780

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     3840

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gt             3892


<210>  17
<211>  6629
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  17
aagcttatac tcgagctcta gattgggaac ccgggtctct cgaattcatg gtggtggtgg       60

ctgctgctcc ttctgctgct acagctgctc ctaaggtgct gctgctgtct ggacagcctg      120

cttctggagg aagagctctg cctctgatgg tgcctggacc tagagctgct ggatctgagg      180

cttctggaac acctcaggct agaaagagac agagactgac acatctgtct cctgaagaaa      240

aggctctgag aagaaagctg aagaatagag tggctgctca gacagctaga gatagaaaga      300

aggctagaat gtctgaactg gaacagcagg tggtggatct ggaagaagaa aatcataagc      360

tgcagctgga aaatcagctg ctgagagaaa agacacatgg actggtggtg gaaaatcagg      420

aactgagaac aagactggga atggatacac tggatcctga tgaagtgcct gaagtggaag      480

ctaagggatc tggagtgaga ctggtggctg gatctgctga atctgctgct ggagctggac      540

ctgtggtgac atctcctgaa catctgccta tggattctga tacagtggct tcttctgatt      600

ctgaatctga tatcctgctg ggaatcctgg ataagctgga tcctgtgatg ttttttaagt      660

gtccttctcc tgaatctgct tctctggaag aactgcctga agtgtatcct gaaggacctt      720

cttctctgcc tgcttctctg tctctgtctg tgggaacatc ttctgctaag ctggaagcta      780

tcaatgaact gatcagattt gatcatgtgt atacaaagcc tctggtgctg gaaatccctt      840

ctgaaacaga atctcagaca aatgtggtgg tgaagatcga agaagctcct ctgtcttctt      900

ctgaagaaga tcatcctgaa tttatcgtgt ctgtgaagaa ggaacctctg gaagatgatt      960

ttatccctga actgggaatc tctaatctgc tgtcttcttc tcattgtctg agacctcctt     1020

cttgtctgct ggatgctcat tctgattgtg gatatgaagg atctccttct cctttttctg     1080

atatgtcttc tcctctggga acagatcatt cttgggaaga tacatttgct aatgaactgt     1140

ttcctcagct gatctctgtg tgagcggccg ctaatcagcc ataccacatt tgtagaggtt     1200

ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca     1260

attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc     1320

acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc     1380

atcaatgtat cttatcatgt ctaccggtag ggcccctctc ttcatgtgag caaaaggcca     1440

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     1500

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     1560

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     1620

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     1680

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     1740

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     1800

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     1860

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     1920

aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     1980

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     2040

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     2100

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgggcg cgcctcatac     2160

tcctgcaggc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     2220

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     2280

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     2340

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     2400

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     2460

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     2520

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     2580

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     2640

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     2700

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     2760

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     2820

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     2880

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     2940

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     3000

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     3060

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     3120

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     3180

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     3240

tccccgaaaa gtgccacctg acgtcaggta ccaagcctag gcctccaaaa aagcctcctc     3300

actacttctg gaatagctca gaggcagagg cggcctcggc ctctgcataa ataaaaaaaa     3360

ttagtcagcc atggggcgga gaatgggcgg aactgggcgg agttaggggc gggatgggcg     3420

gagttagggg cgggactatg gttgctgact aattgagatg catgctttgc atacttctgc     3480

ctgctgggga gcctggggac tttccacacc tggttgctga ctaattgaga tgcatgcttt     3540

gcatacttct gcctgctggg gagcctgggg actttccaca ccggatccac catggccaag     3600

ttgaccagtg ccgttccggt gctcaccgcg cgcgacgtcg ccggagcggt cgagttctgg     3660

accgaccggc tcgggttctc ccgggacttc gtggaggacg acttcgccgg tgtggtccgg     3720

gacgacgtga ccctgttcat cagcgcggtc caggaccagg tggtgccgga caacaccctg     3780

gcctgggtgt gggtgcgcgg cctggacgag ctgtacgccg agtggtcgga ggtcgtgtcc     3840

acgaacttcc gggacgcctc cgggccggcc atgaccgaga tcggcgagca gccgtggggg     3900

cgggagttcg ccctgcgcga cccggccggc aactgcgtgc acttcgtggc cgaggagcag     3960

gactgaacgc gtgctgtaag tctgcagaaa ttgatgatct attaaacaat aaagatgtcc     4020

actaaaatgg aagtttttcc tgtcatactt tgttaagaag ggtgagaaca gagtacctac     4080

attttgaatg gaaggattgg agctacgggg gtgggggtgg ggtgggatta gataaatgcc     4140

tgctctttac tgaaggctct ttactattgc tttatgataa tgtttcatag ttggatatca     4200

taatttaaac aagcaaaacc aaattaaggg ccagctcatt cctcccactc atgatctatg     4260

gatctataga tctctcgtgc agctggggct ctagggggta tccccacgcg ccctgtagcg     4320

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     4380

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     4440

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     4500

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     4560

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     4620

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     4680

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct     4740

gtggaatgtg tgtcagttag tcgcgaggcc tccgcgccgg gttttggcgc ctcccgcggg     4800

cgcccccctc ctcacggcga gcgctgccac gtcagacgaa gggcgcagcg agcgtcctga     4860

tccttccgcc cggacgctca ggacagcggc ccgctgctca taagactcgg ccttagaacc     4920

ccagtatcag cagaaggaca ttttaggacg ggacttgggt gactctaggg cactggtttt     4980

ctttccagag agcggaacag gcgaggaaaa gtagtccctt ctcggcgatt ctgcggaggg     5040

atctccgtgg ggcggtgaac gccgatgatt atataaggac gcgccgggtg tggcacagct     5100

agttccgtcg cagccgggat ttgggtcgcg gttcttgttt gtggatcgct gtgatcgtca     5160

cttggtgagt agcgggctgc tgggctggcc ggggctttcg tggccgccgg gccgctcggt     5220

gggacggaag cgtgtggaga gaccgccaag ggctgtagtc tgggtccgcg agcaaggttg     5280

ccctgaactg ggggttgggg ggagcgcagc aaaatggcgg ctgttcccga gtcttgaatg     5340

gaagacgctt gtgaggcggg ctgtgaggtc gttgaaacaa ggtggggggc atggtgggcg     5400

gcaagaaccc aaggtcttga ggccttcgct aatgcgggaa agctcttatt cgggtgagat     5460

gggctggggc accatctggg gaccctgacg tgaagtttgt cactgactgg agaactcggt     5520

ttgtcgtctg ttgcgggggc ggcagttatg gcggtgccgt tgggcagtgc acccgtacct     5580

ttgggagcgc gcgccctcgt cgtgtcgtga cgtcacccgt tctgttggct tataatgcag     5640

ggtggggcca cctgccggta ggtgtgcggt aggcttttct ccgtcgcagg acgcagggtt     5700

cgggcctagg gtaggctctc ctgaatcgac aggcgccgga cctctggtga ggggagggat     5760

aagtgaggcg tcagtttctt tggtcggttt tatgtaccta tcttcttaag tagctgaagc     5820

tccggttttg aactatgcgc tcggggttgg cgagtgtgtt ttgtgaagtt ttttaggcac     5880

cttttgaaat gtaatcattt gggtcaatat gtaattttca gtgttagact agtaaattgt     5940

ccgctaaatt ctggccgttt ttggcttttt tgttagacgt cgaccgatcc tgagaacttc     6000

agggtgagtt tggggaccct tgattgttct ttctttttcg ctattgtaaa attcatgtta     6060

tatggagggg gcaaagtttt cagggtgttg tttagaatgg gaagatgtcc cttgtatcac     6120

catggaccct catgataatt ttgtttcttt cactttctac tctgttgaca accattgtct     6180

cctcttattt tcttttcatt ttctgtaact ttttcgttaa actttagctt gcatttgtaa     6240

cgaattttta aattcacttt tgtttatttg tcagattgta agtactttct ctaatcactt     6300

ttttttcaag gcaatcaggg tatattatat tgtacttcag cacagtttta gagaacaatt     6360

gttataatta aatgataagg tagaatattt ctgcatataa attctggctg gcgtggaaat     6420

attcttattg gtagaaacaa ctacaccctg gtcatcatcc tgcctttctc tttatggtta     6480

caatgatata cactgtttga gatgaggata aaatactctg agtccaaacc gggcccctct     6540

gctaaccatg ttcatgcctt cttctctttc ctacagctcc tgggcaacgt gctggttgtt     6600

gtgctgtctc atcattttgg caaagaatt                                       6629


<210>  18
<211>  3264
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  18
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct      420

ggccggggct ttcgtggccg ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc      480

caagggctgt agtctgggtc cgcgagcaag gttgccctga actgggggtt ggggggagcg      540

cagcaaaatg gcggctgttc ccgagtcttg aatggaagac gcttgtgagg cgggctgtga      600

ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt      660

cgctaatgcg ggaaagctct tattcgggtg agatgggctg gggcaccatc tggggaccct      720

gacgtgaagt ttgtcactga ctggagaact cggtttgtcg tctgttgcgg gggcggcagt      780

tatggcggtg ccgttgggca gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc      840

gtgacgtcac ccgttctgtt ggcttataat gcagggtggg gccacctgcc ggtaggtgtg      900

cggtaggctt ttctccgtcg caggacgcag ggttcgggcc tagggtaggc tctcctgaat      960

cgacaggcgc cggacctctg gtgaggggag ggataagtga ggcgtcagtt tctttggtcg     1020

gttttatgta cctatcttct taagtagctg aagctccggt tttgaactat gcgctcgggg     1080

ttggcgagtg tgttttgtga agttttttag gcaccttttg aaatgtaatc atttgggtca     1140

atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta aattctggcc gtttttggct     1200

tttttgttag acgtcgaccg atcctgagaa cttcagggtg agtttgggga cccttgattg     1260

ttctttcttt ttcgctattg taaaattcat gttatatgga gggggcaaag ttttcagggt     1320

gttgtttaga atgggaagat gtcccttgta tcaccatgga ccctcatgat aattttgttt     1380

ctttcacttt ctactctgtt gacaaccatt gtctcctctt attttctttt cattttctgt     1440

aactttttcg ttaaacttta gcttgcattt gtaacgaatt tttaaattca cttttgttta     1500

tttgtcagat tgtaagtact ttctctaatc actttttttt caaggcaatc agggtatatt     1560

atattgtact tcagcacagt tttagagaac aattgttata attaaatgat aaggtagaat     1620

atttctgcat ataaattctg gctggcgtgg aaatattctt attggtagaa acaactacac     1680

cctggtcatc atcctgcctt tctctttatg gttacaatga tatacactgt ttgagatgag     1740

gataaaatac tctgagtcca aaccgggccc ctctgctaac catgttcatg ccttcttctc     1800

tttcctacag ctcctgggca acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga     1860

attaagctta tactcgagct ctagattggg aacccgggtc tctcgaattc atggtggtgg     1920

tggctgctgc tccttctgct gctacagctg ctcctaaggt gctgctgctg tctggacagc     1980

ctgcttctgg aggaagagct ctgcctctga tggtgcctgg acctagagct gctggatctg     2040

aggcttctgg aacacctcag gctagaaaga gacagagact gacacatctg tctcctgaag     2100

aaaaggctct gagaagaaag ctgaagaata gagtggctgc tcagacagct agagatagaa     2160

agaaggctag aatgtctgaa ctggaacagc aggtggtgga tctggaagaa gaaaatcata     2220

agctgcagct ggaaaatcag ctgctgagag aaaagacaca tggactggtg gtggaaaatc     2280

aggaactgag aacaagactg ggaatggata cactggatcc tgatgaagtg cctgaagtgg     2340

aagctaaggg atctggagtg agactggtgg ctggatctgc tgaatctgct gctggagctg     2400

gacctgtggt gacatctcct gaacatctgc ctatggattc tgatacagtg gcttcttctg     2460

attctgaatc tgatatcctg ctgggaatcc tggataagct ggatcctgtg atgtttttta     2520

agtgtccttc tcctgaatct gcttctctgg aagaactgcc tgaagtgtat cctgaaggac     2580

cttcttctct gcctgcttct ctgtctctgt ctgtgggaac atcttctgct aagctggaag     2640

ctatcaatga actgatcaga tttgatcatg tgtatacaaa gcctctggtg ctggaaatcc     2700

cttctgaaac agaatctcag acaaatgtgg tggtgaagat cgaagaagct cctctgtctt     2760

cttctgaaga agatcatcct gaatttatcg tgtctgtgaa gaaggaacct ctggaagatg     2820

attttatccc tgaactggga atctctaatc tgctgtcttc ttctcattgt ctgagacctc     2880

cttcttgtct gctggatgct cattctgatt gtggatatga aggatctcct tctccttttt     2940

ctgatatgtc ttctcctctg ggaacagatc attcttggga agatacattt gctaatgaac     3000

tgtttcctca gctgatctct gtgtgagcgg ccgctaatca gccataccac atttgtagag     3060

gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat     3120

gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc     3180

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     3240

ctcatcaatg tatcttatca tgtc                                            3264


<210>  19
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Val Gln Val Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Ala Trp Lys Met Ser Gly Leu Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  20
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr Ala Met Thr Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly 
        35                  40                  45              


Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
65                  70                  75                  80  


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Gly Ala 
                85                  90                  95      


Trp Lys Met Ser Gly Leu Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110 


<210>  21
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Thr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  22
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
1               5                   10                  15      


Thr Cys Arg Ala Ser Gln Asp Ile Ser Asp Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ile Pro Arg Leu Leu Ile Tyr Thr Thr Ser Thr 
        35                  40                  45              


Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Lys Tyr Asp Ser Ala Pro Leu Thr Phe Gly Gly Gly 
                85                  90                  95      


Thr Lys Val Glu 
            100 


<210>  23
<211>  2971
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  23
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcag aggtgcaggt gttggagtct gggggagact tggtacagcc tggggggtcc     1440

ctgagactct cctgtgcagc ctctggattc acctttagtg cctatgccat gacctgggtc     1500

cgccaggctc cagggaaggg gctggagtgg gtctcagcta ttagtggtag tggtggtagc     1560

gcatactacg cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac     1620

acggtatatc tgcagatgaa cagcctgaga gccgaggaca cggccgtata ttactgtgcg     1680

aaagatgggg cctggaaaat gtccggtttg gacgtctggg gccaagggac cacggtcatc     1740

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc     1800

acctccgaga gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     1860

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1920

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1980

acgaagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga     2040

gttgagtcca aatatggtcc cccatgccca ccctgcccag cacctgagtt cctgggggga     2100

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct     2160

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg     2220

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac     2280

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag     2340

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     2400

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     2460

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     2520

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     2580

ctggactccg acggctcctt cttcctctac agcaggctca ccgtggacaa gagcaggtgg     2640

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     2700

cagaagtccc tctccctgtc tctgggtaaa tgagcggccg ctaatcagcc ataccacatt     2760

tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa     2820

aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag     2880

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     2940

gtccaaactc atcaatgtat cttatcatgt c                                    2971


<210>  24
<211>  7013
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  24
tcgcgatgtg tgactagtta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcatg atagaagcac      600

tctactattc gtcgaccgat cctgagaact tcagggtgag tttggggacc cttgattgtt      660

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      720

tgtttagaat gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      780

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      840

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      900

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat      960

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1020

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacaccc     1080

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1140

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctctt     1200

tcctacagct cctgggcaac gtgctggttg ttgtgctgtc tcatcatttt ggcaaagaat     1260

taagcttata ctcgagctct agattgggaa cccgggtctc tcgaattcga gatctccacc     1320

atgcacagac ctagacgtcg tggaactcgt ccacctccac tggcactgct cgctgctctc     1380

ctcctggctg cacgtggtgc tgatgcagag gtgcaggtgt tggagtctgg gggagacttg     1440

gtacagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac ctttagtgcc     1500

tatgccatga cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctatt     1560

agtggtagtg gtggtagcgc atactacgca gactccgtga agggccggtt caccatctcc     1620

agagacaatt ccaagaacac ggtatatctg cagatgaaca gcctgagagc cgaggacacg     1680

gccgtatatt actgtgcgaa agatggggcc tggaaaatgt ccggtttgga cgtctggggc     1740

caagggacca cggtcatcgt ctcctcagcc tccaccaagg gcccatcggt cttccccctg     1800

gcgccctgct ccaggagcac ctccgagagc acagccgccc tgggctgcct ggtcaaggac     1860

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac     1920

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     1980

ccctccagca gcttgggcac gaagacctac acctgcaacg tagatcacaa gcccagcaac     2040

accaaggtgg acaagagagt tgagtccaaa tatggtcccc catgcccacc ctgcccagca     2100

cctgagttcc tggggggacc atcagtcttc ctgttccccc caaaacccaa ggacactctc     2160

atgatctccc ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca ggaagacccc     2220

gaggtccagt tcaactggta cgtggatggc gtggaggtgc ataatgccaa gacaaagccg     2280

cgggaggagc agttcaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     2340

gactggctga acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccgtcctcc     2400

atcgagaaaa ccatctccaa agccaaaggg cagccccgag agccacaggt gtacaccctg     2460

cccccatccc aggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     2520

ttctacccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     2580

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caggctcacc     2640

gtggacaaga gcaggtggca ggaggggaat gtcttctcat gctccgtgat gcatgaggct     2700

ctgcacaacc actacacaca gaagtccctc tccctgtctc tgggtaaatg agcggccgct     2760

aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc     2820

cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta     2880

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     2940

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct accggtcctg     3000

cagggcccct ctcttcatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     3060

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     3120

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     3180

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     3240

tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt     3300

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     3360

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     3420

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     3480

cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct     3540

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     3600

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     3660

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     3720

ttaagggatt ttggtcatgg gcgcgcctca tactcctgca ggcatgagat tatcaaaaag     3780

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     3840

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     3900

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     3960

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     4020

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     4080

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     4140

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     4200

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     4260

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     4320

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     4380

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     4440

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     4500

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     4560

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     4620

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     4680

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     4740

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     4800

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcag     4860

gtaccaagcc taggcctcca aaaaagcctc ctcactactt ctggaatagc tcagaggcag     4920

aggcggcctc ggcctctgca taaataaaaa aaattagtca gccatggggc ggagaatggg     4980

cggaactggg cggagttagg ggcgggatgg gcggagttag gggcgggact atggttgctg     5040

actaattgag atgcatgctt tgcatacttc tgcctgctgg ggagcctggg gactttccac     5100

acctggttgc tgactaattg agatgcatgc tttgcatact tctgcctgct ggggagcctg     5160

gggactttcc acaccggatc caccatggat agatccggaa agcctgaact caccgcgacg     5220

tctgtcgaga agtttctgat cgaaaagttc gacagcgtct ccgacctgat gcagctctcg     5280

gagggcgaag aatctcgtgc tttcagcttc gatgtaggag ggcgtggata tgtcctgcgg     5340

gtaaatagct gcgccgatgg tttctacaaa gatcgttatg tttatcggca ctttgcatcg     5400

gccgcgctcc cgattccgga agtgcttgac attggggagt tcagcgagag cctgacctat     5460

tgcatctccc gccgtgcaca gggtgtcacg ttgcaagacc tgcctgaaac cgaactgccc     5520

gctgttctgc agccggtcgc ggaggccatg gatgcgatcg ctgcggccga tcttagccag     5580

acgagcgggt tcggcccatt cggaccgcaa ggaatcggtc aatacactac atggcgtgat     5640

ttcatatgcg cgattgctga tccccatgtg tatcactggc aaactgtgat ggacgacacc     5700

gtcagtgcgt ccgtcgcgca ggctctcgat gagctgatgc tttgggccga ggactgcccc     5760

gaagtccggc acctcgtgca cgcggatttc ggctccaaca atgtcctgac ggacaatggc     5820

cgcataacag cggtcattga ctggagcgag gcgatgttcg gggattccca atacgaggtc     5880

gccaacatct tcttctggag gccgtggttg gcttgtatgg agcagcagac gcgctacttc     5940

gagcggaggc atccggagct tgcaggatcg ccgcggctcc gggcgtatat gctccgcatt     6000

ggtcttgacc aactctatca gagcttggtt gacggcaatt tcgatgatgc agcttgggcg     6060

cagggtcgat gcgacgcaat cgtccgatcc ggagccggga ctgtcgggcg tacacaaatc     6120

gcccgcagaa gcgcggccgt ctggaccgat ggctgtgtag aagtactcgc cgatagtgga     6180

aaccgacgcc ccagcactcg tccgagggca aaggaataga cgcgtgctgt aagtctgcag     6240

aaattgatga tctattaaac aataaagatg tccactaaaa tggaagtttt tcctgtcata     6300

ctttgttaag aagggtgaga acagagtacc tacattttga atggaaggat tggagctacg     6360

ggggtggggg tggggtggga ttagataaat gcctgctctt tactgaaggc tctttactat     6420

tgctttatga taatgtttca tagttggata tcataattta aacaagcaaa accaaattaa     6480

gggccagctc attcctccca ctcatgatct atggatctat agatctctcg tgcagctggg     6540

gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     6600

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     6660

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     6720

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     6780

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     6840

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     6900

tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     6960

tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt tag            7013


<210>  25
<211>  2272
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  25
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcag acatccagat gacccagtct ccagcctccc tgtctgcatc tgttggagac     1440

agagtcacca tcacttgtcg ggcgagtcag gacattagcg attatttagc ctggtatcag     1500

cagaaaccag ggaaaattcc taggctcctg atctatacta catccacttt gcaatcaggg     1560

gtcccatctc ggttccgtgg cagtgggtct gggacagatt tcactctcac catcagcagc     1620

ctgcagcctg aagatgttgc aacttattac tgtcagaagt atgacagtgc cccgctcact     1680

ttcggcggag ggaccaaggt ggagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc     1740

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat     1800

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt     1860

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc     1920

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc     1980

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttaggcggcc     2040

gctaatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct     2100

ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc     2160

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     2220

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tc             2272


<210>  26
<211>  6335
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  26
tcgagctcta gattgggaac ccgggtctct cgaattcgag atctccacca tgcacagacc       60

tagacgtcgt ggaactcgtc cacctccact ggcactgctc gctgctctcc tcctggctgc      120

acgtggtgct gatgcagaca tccagatgac ccagtctcca gcctccctgt ctgcatctgt      180

tggagacaga gtcaccatca cttgtcgggc gagtcaggac attagcgatt atttagcctg      240

gtatcagcag aaaccaggga aaattcctag gctcctgatc tatactacat ccactttgca      300

atcaggggtc ccatctcggt tccgtggcag tgggtctggg acagatttca ctctcaccat      360

cagcagcctg cagcctgaag atgttgcaac ttattactgt cagaagtatg acagtgcccc      420

gctcactttc ggcggaggga ccaaggtgga gatcaaacga actgtggctg caccatctgt      480

cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct      540

gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca      600

atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct      660

cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga      720

agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta      780

ggcggccgct aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc      840

cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta      900

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat      960

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     1020

accggtaggg cccctctctt catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     1080

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     1140

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     1200

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     1260

gcctttctcc cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt     1320

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     1380

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     1440

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     1500

gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc     1560

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     1620

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     1680

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     1740

tcacgttaag ggattttggt catgggcgcg ggcatgagat tatcaaaaag gatcttcacc     1800

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1860

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1920

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1980

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     2040

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     2100

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2160

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2220

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2280

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2340

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2400

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2460

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2520

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2580

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2640

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2700

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2760

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2820

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcag gtacacttag     2880

gcgcgccatt agagttcctg caggctacat ggtaccaagc ctaggcctcc aaaaaagcct     2940

cctcactact tctggaatag ctcagaggca gaggcggcct cggcctctgc ataaataaaa     3000

aaaattagtc agccatgggg cggagaatgg gcggaactgg gcggagttag gggcgggatg     3060

ggcggagtta ggggcgggac tatggttgct gactaattga gatgcatgct ttgcatactt     3120

ctgcctgctg gggagcctgg ggactttcca cacctggttg ctgactaatt gagatgcatg     3180

ctttgcatac ttctgcctgc tggggagcct ggggactttc cacaccggat ccaccatgga     3240

tagatccgga aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt     3300

cgacagcgtc tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt     3360

cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa     3420

agatcgttat gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga     3480

cattggggag ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac     3540

gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat     3600

ggatgcgatc gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca     3660

aggaatcggt caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt     3720

gtatcactgg caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga     3780

tgagctgatg ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt     3840

cggctccaac aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga     3900

ggcgatgttc ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt     3960

ggcttgtatg gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc     4020

gccgcggctc cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt     4080

tgacggcaat ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc     4140

cggagccggg actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga     4200

tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc     4260

aaaggaatag acgcgtgctg taagtctgca gaaattgatg atctattaaa caataaagat     4320

gtccactaaa atggaagttt ttcctgtcat actttgttaa gaagggtgag aacagagtac     4380

ctacattttg aatggaagga ttggagctac gggggtgggg gtggggtggg attagataaa     4440

tgcctgctct ttactgaagg ctctttacta ttgctttatg ataatgtttc atagttggat     4500

atcataattt aaacaagcaa aaccaaatta agggccagct cattcctccc actcatgatc     4560

tatggatcta tagatctctc gtgcagctgg ggctctaggg ggtatcccca cgcgccctgt     4620

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     4680

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     4740

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     4800

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     4860

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     4920

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     4980

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa     5040

ttctgtggaa tgtgtgtcag ttagtcgcga tgtgtgacta gttagttatt aatagtaatc     5100

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     5160

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     5220

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     5280

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     5340

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     5400

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg     5460

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc     5520

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg     5580

taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat     5640

aagcagagct catgatagaa gcactctact attcgtcgac cgatcctgag aacttcaggg     5700

tgagtttggg gacccttgat tgttctttct ttttcgctat tgtaaaattc atgttatatg     5760

gagggggcaa agttttcagg gtgttgttta gaatgggaag atgtcccttg tatcaccatg     5820

gaccctcatg ataattttgt ttctttcact ttctactctg ttgacaacca ttgtctcctc     5880

ttattttctt ttcattttct gtaacttttt cgttaaactt tagcttgcat ttgtaacgaa     5940

tttttaaatt cacttttgtt tatttgtcag attgtaagta ctttctctaa tcactttttt     6000

ttcaaggcaa tcagggtata ttatattgta cttcagcaca gttttagaga acaattgtta     6060

taattaaatg ataaggtaga atatttctgc atataaattc tggctggcgt ggaaatattc     6120

ttattggtag aaacaactac accctggtca tcatcctgcc tttctcttta tggttacaat     6180

gatatacact gtttgagatg aggataaaat actctgagtc caaaccgggc ccctctgcta     6240

accatgttca tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc     6300

tgtctcatca ttttggcaaa gaattaagct tatac                                6335


<210>  27
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Ile Thr Phe Gly Gly Leu Ile Ala Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  28
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Ile His Trp Val 
            20                  25                  30          


Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Gly Pro 
        35                  40                  45              


Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu Ile Thr 
                85                  90                  95      


Phe Gly Gly Leu Ile Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


<210>  29
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asp Asn Ser Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
1               5                   10                  15      


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asp Asn Ser Gln Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  31
<211>  2986
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  31
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcag aggtgcagct ggtggagtct gggggaggct tggtacagcc gggggggtcc     1440

ctgagactct cctgtgcagc ctctggattc accttcagta gctacgacat acactgggtc     1500

cgtcaagcta caggaaaagg tctggagtgg gtctcagcta ttggtcctgc tggtgacaca     1560

tactatccag gctccgtgaa gggccgattc accatctcca gagaaaatgc caagaactcc     1620

ttgtatcttc aaatgaacag cctgagagcc ggggacacgg ctgtgtatta ctgtgcaaga     1680

ggtttgatta cgtttggggg gcttatcgcc ccgtttgact actggggcca gggaaccctg     1740

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc accctcctcc     1800

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa     1860

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     1920

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     1980

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac     2040

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct     2100

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     2160

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     2220

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     2280

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     2340

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     2400

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     2460

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2520

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2580

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2640

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2700

cacaaccact acacgcagaa gtccctctcc ctgtctccgg gtaaatgagc ggccgctaat     2760

cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct     2820

gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa     2880

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     2940

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtc                    2986


<210>  32
<211>  7028
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  32
tcgcgatgtg tgactagtta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcatg atagaagcac      600

tctactattc gtcgaccgat cctgagaact tcagggtgag tttggggacc cttgattgtt      660

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      720

tgtttagaat gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      780

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      840

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      900

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat      960

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1020

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacaccc     1080

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1140

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctctt     1200

tcctacagct cctgggcaac gtgctggttg ttgtgctgtc tcatcatttt ggcaaagaat     1260

taagcttata ctcgagctct agattgggaa cccgggtctc tcgaattcga gatctccacc     1320

atgcacagac ctagacgtcg tggaactcgt ccacctccac tggcactgct cgctgctctc     1380

ctcctggctg cacgtggtgc tgatgcagag gtgcagctgg tggagtctgg gggaggcttg     1440

gtacagccgg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc     1500

tacgacatac actgggtccg tcaagctaca ggaaaaggtc tggagtgggt ctcagctatt     1560

ggtcctgctg gtgacacata ctatccaggc tccgtgaagg gccgattcac catctccaga     1620

gaaaatgcca agaactcctt gtatcttcaa atgaacagcc tgagagccgg ggacacggct     1680

gtgtattact gtgcaagagg tttgattacg tttggggggc ttatcgcccc gtttgactac     1740

tggggccagg gaaccctggt caccgtctcc tcagcctcca ccaagggccc atcggtcttc     1800

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1860

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1920

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1980

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     2040

agcaacacca aggtggacaa gaaagttgag cccaaatctt gtgacaaaac tcacacatgc     2100

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa     2160

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg     2220

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     2280

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     2340

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     2400

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     2460

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     2520

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     2580

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     2640

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     2700

gtgatgcatg aggctctgca caaccactac acgcagaagt ccctctccct gtctccgggt     2760

aaatgagcgg ccgctaatca gccataccac atttgtagag gttttacttg ctttaaaaaa     2820

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     2880

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     2940

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca     3000

tgtctaccgg tcctgcaggg cccctctctt catgtgagca aaaggccagc aaaaggccag     3060

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     3120

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     3180

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     3240

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcaatgct cacgctgtag     3300

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     3360

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     3420

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     3480

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt     3540

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     3600

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     3660

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     3720

gaacgaaaac tcacgttaag ggattttggt catgggcgcg cctcatactc ctgcaggcat     3780

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     3840

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     3900

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     3960

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     4020

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     4080

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     4140

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     4200

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     4260

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     4320

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     4380

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     4440

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     4500

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     4560

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     4620

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     4680

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     4740

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     4800

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     4860

gccacctgac gtcaggtacc aagcctaggc ctccaaaaaa gcctcctcac tacttctgga     4920

atagctcaga ggcagaggcg gcctcggcct ctgcataaat aaaaaaaatt agtcagccat     4980

ggggcggaga atgggcggaa ctgggcggag ttaggggcgg gatgggcgga gttaggggcg     5040

ggactatggt tgctgactaa ttgagatgca tgctttgcat acttctgcct gctggggagc     5100

ctggggactt tccacacctg gttgctgact aattgagatg catgctttgc atacttctgc     5160

ctgctgggga gcctggggac tttccacacc ggatccacca tggatagatc cggaaagcct     5220

gaactcaccg cgacgtctgt cgagaagttt ctgatcgaaa agttcgacag cgtctccgac     5280

ctgatgcagc tctcggaggg cgaagaatct cgtgctttca gcttcgatgt aggagggcgt     5340

ggatatgtcc tgcgggtaaa tagctgcgcc gatggtttct acaaagatcg ttatgtttat     5400

cggcactttg catcggccgc gctcccgatt ccggaagtgc ttgacattgg ggagttcagc     5460

gagagcctga cctattgcat ctcccgccgt gcacagggtg tcacgttgca agacctgcct     5520

gaaaccgaac tgcccgctgt tctgcagccg gtcgcggagg ccatggatgc gatcgctgcg     5580

gccgatctta gccagacgag cgggttcggc ccattcggac cgcaaggaat cggtcaatac     5640

actacatggc gtgatttcat atgcgcgatt gctgatcccc atgtgtatca ctggcaaact     5700

gtgatggacg acaccgtcag tgcgtccgtc gcgcaggctc tcgatgagct gatgctttgg     5760

gccgaggact gccccgaagt ccggcacctc gtgcacgcgg atttcggctc caacaatgtc     5820

ctgacggaca atggccgcat aacagcggtc attgactgga gcgaggcgat gttcggggat     5880

tcccaatacg aggtcgccaa catcttcttc tggaggccgt ggttggcttg tatggagcag     5940

cagacgcgct acttcgagcg gaggcatccg gagcttgcag gatcgccgcg gctccgggcg     6000

tatatgctcc gcattggtct tgaccaactc tatcagagct tggttgacgg caatttcgat     6060

gatgcagctt gggcgcaggg tcgatgcgac gcaatcgtcc gatccggagc cgggactgtc     6120

gggcgtacac aaatcgcccg cagaagcgcg gccgtctgga ccgatggctg tgtagaagta     6180

ctcgccgata gtggaaaccg acgccccagc actcgtccga gggcaaagga atagacgcgt     6240

gctgtaagtc tgcagaaatt gatgatctat taaacaataa agatgtccac taaaatggaa     6300

gtttttcctg tcatactttg ttaagaaggg tgagaacaga gtacctacat tttgaatgga     6360

aggattggag ctacgggggt gggggtgggg tgggattaga taaatgcctg ctctttactg     6420

aaggctcttt actattgctt tatgataatg tttcatagtt ggatatcata atttaaacaa     6480

gcaaaaccaa attaagggcc agctcattcc tcccactcat gatctatgga tctatagatc     6540

tctcgtgcag ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg     6600

cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg     6660

ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc     6720

taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa     6780

aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc     6840

ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac     6900

tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt     6960

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg     7020

tcagttag                                                              7028


<210>  33
<211>  2272
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  33
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcag aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa     1440

agagccaccc tctcctgcag ggccagtcag agtgttagca gcacctactt agcctggtac     1500

cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccag cagggccact     1560

ggcatcccag acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     1620

agactggagc ctgaagattt tgcagtgtat tactgtcagc attatgataa ctcacaaacg     1680

ttcggccaag ggaccaaggt ggagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc     1740

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat     1800

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt     1860

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc     1920

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc     1980

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttaggcggcc     2040

gctaatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct     2100

ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc     2160

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     2220

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tc             2272


<210>  34
<211>  6335
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  34
tcgagctcta gattgggaac ccgggtctct cgaattcgag atctccacca tgcacagacc       60

tagacgtcgt ggaactcgtc cacctccact ggcactgctc gctgctctcc tcctggctgc      120

acgtggtgct gatgcagaaa ttgtgttgac gcagtctcca ggcaccctgt ctttgtctcc      180

aggggaaaga gccaccctct cctgcagggc cagtcagagt gttagcagca cctacttagc      240

ctggtaccag cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag      300

ggccactggc atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac      360

catcagcaga ctggagcctg aagattttgc agtgtattac tgtcagcatt atgataactc      420

acaaacgttc ggccaaggga ccaaggtgga gatcaaacga actgtggctg caccatctgt      480

cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct      540

gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca      600

atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct      660

cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga      720

agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta      780

ggcggccgct aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc      840

cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta      900

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat      960

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     1020

accggtaggg cccctctctt catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     1080

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     1140

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     1200

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     1260

gcctttctcc cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt     1320

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     1380

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     1440

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     1500

gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc     1560

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     1620

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     1680

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     1740

tcacgttaag ggattttggt catgggcgcg ggcatgagat tatcaaaaag gatcttcacc     1800

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1860

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1920

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1980

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     2040

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     2100

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2160

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2220

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2280

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2340

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2400

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2460

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2520

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2580

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2640

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2700

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2760

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2820

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcag gtacacttag     2880

gcgcgccatt agagttcctg caggctacat ggtaccaagc ctaggcctcc aaaaaagcct     2940

cctcactact tctggaatag ctcagaggca gaggcggcct cggcctctgc ataaataaaa     3000

aaaattagtc agccatgggg cggagaatgg gcggaactgg gcggagttag gggcgggatg     3060

ggcggagtta ggggcgggac tatggttgct gactaattga gatgcatgct ttgcatactt     3120

ctgcctgctg gggagcctgg ggactttcca cacctggttg ctgactaatt gagatgcatg     3180

ctttgcatac ttctgcctgc tggggagcct ggggactttc cacaccggat ccaccatgga     3240

tagatccgga aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt     3300

cgacagcgtc tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt     3360

cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa     3420

agatcgttat gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga     3480

cattggggag ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac     3540

gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat     3600

ggatgcgatc gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca     3660

aggaatcggt caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt     3720

gtatcactgg caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga     3780

tgagctgatg ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt     3840

cggctccaac aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga     3900

ggcgatgttc ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt     3960

ggcttgtatg gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc     4020

gccgcggctc cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt     4080

tgacggcaat ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc     4140

cggagccggg actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga     4200

tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc     4260

aaaggaatag acgcgtgctg taagtctgca gaaattgatg atctattaaa caataaagat     4320

gtccactaaa atggaagttt ttcctgtcat actttgttaa gaagggtgag aacagagtac     4380

ctacattttg aatggaagga ttggagctac gggggtgggg gtggggtggg attagataaa     4440

tgcctgctct ttactgaagg ctctttacta ttgctttatg ataatgtttc atagttggat     4500

atcataattt aaacaagcaa aaccaaatta agggccagct cattcctccc actcatgatc     4560

tatggatcta tagatctctc gtgcagctgg ggctctaggg ggtatcccca cgcgccctgt     4620

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     4680

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     4740

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     4800

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     4860

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     4920

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     4980

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa     5040

ttctgtggaa tgtgtgtcag ttagtcgcga tgtgtgacta gttagttatt aatagtaatc     5100

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     5160

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     5220

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     5280

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     5340

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     5400

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg     5460

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc     5520

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg     5580

taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat     5640

aagcagagct catgatagaa gcactctact attcgtcgac cgatcctgag aacttcaggg     5700

tgagtttggg gacccttgat tgttctttct ttttcgctat tgtaaaattc atgttatatg     5760

gagggggcaa agttttcagg gtgttgttta gaatgggaag atgtcccttg tatcaccatg     5820

gaccctcatg ataattttgt ttctttcact ttctactctg ttgacaacca ttgtctcctc     5880

ttattttctt ttcattttct gtaacttttt cgttaaactt tagcttgcat ttgtaacgaa     5940

tttttaaatt cacttttgtt tatttgtcag attgtaagta ctttctctaa tcactttttt     6000

ttcaaggcaa tcagggtata ttatattgta cttcagcaca gttttagaga acaattgtta     6060

taattaaatg ataaggtaga atatttctgc atataaattc tggctggcgt ggaaatattc     6120

ttattggtag aaacaactac accctggtca tcatcctgcc tttctcttta tggttacaat     6180

gatatacact gtttgagatg aggataaaat actctgagtc caaaccgggc ccctctgcta     6240

accatgttca tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc     6300

tgtctcatca ttttggcaaa gaattaagct tatac                                6335


<210>  35
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Tyr Gly Gly Ser Phe Ser Ile His 
            20                  25                  30          


His Trp Thr Trp Ile Arg His Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ala Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Arg Phe Leu Asp Trp Leu Ser Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  36
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr 
1               5                   10                  15      


Cys Thr Val Tyr Gly Gly Ser Phe Ser Ile His His Trp Thr Trp Ile 
            20                  25                  30          


Arg His Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His 
        35                  40                  45              


Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile 
    50                  55                  60                  


Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ala Val 
65                  70                  75                  80  


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu Arg Phe 
                85                  90                  95      


Leu Asp Trp Leu Ser Ser Tyr 
            100             


<210>  37
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Thr Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  38
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Thr Ala Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  39
<211>  2977
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  39
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcac aggtacagct gcagcagtcg ggcgcaggac tgttgaagcc ttcggagacc     1440

ctgtccctca cctgcactgt ctatggtgga tccttcagta ttcatcactg gacctggatc     1500

cgccatcccc cagggaaggg gctggagtgg attggggaga tcaatcatcg tggaagcacc     1560

aactacaacc cgtccctcaa gagtcgagtc accatatcaa tagacacgtc caagaaccag     1620

ttctccctga agctgagcgc tgtgaccgcc gcggacacgg ctgtatatta ctgtgcgaga     1680

ggcttacgat ttttggactg gttatcgtcc tactttgact actggggcca gggaaccctg     1740

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc gccctgctcc     1800

aggagcacct ccgagagcac agccgccctg ggctgcctgg tcaaggacta cttccccgaa     1860

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct     1920

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc     1980

ttgggcacga agacctacac ctgcaacgta gatcacaagc ccagcaacac caaggtggac     2040

aagagagttg agtccaaata tggtccccca tgcccaccct gcccagcacc tgagttcctg     2100

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg     2160

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc     2220

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     2280

ttcaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac     2340

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     2400

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag     2460

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc     2520

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     2580

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctcaccgt ggacaagagc     2640

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     2700

tacacacaga agtccctctc cctgtctctg ggtaaatgag cggccgctaa tcagccatac     2760

cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa     2820

acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa     2880

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     2940

tggtttgtcc aaactcatca atgtatctta tcatgtc                              2977


<210>  40
<211>  7019
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  40
tcgcgatgtg tgactagtta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcatg atagaagcac      600

tctactattc gtcgaccgat cctgagaact tcagggtgag tttggggacc cttgattgtt      660

ctttcttttt cgctattgta aaattcatgt tatatggagg gggcaaagtt ttcagggtgt      720

tgtttagaat gggaagatgt cccttgtatc accatggacc ctcatgataa ttttgtttct      780

ttcactttct actctgttga caaccattgt ctcctcttat tttcttttca ttttctgtaa      840

ctttttcgtt aaactttagc ttgcatttgt aacgaatttt taaattcact tttgtttatt      900

tgtcagattg taagtacttt ctctaatcac ttttttttca aggcaatcag ggtatattat      960

attgtacttc agcacagttt tagagaacaa ttgttataat taaatgataa ggtagaatat     1020

ttctgcatat aaattctggc tggcgtggaa atattcttat tggtagaaac aactacaccc     1080

tggtcatcat cctgcctttc tctttatggt tacaatgata tacactgttt gagatgagga     1140

taaaatactc tgagtccaaa ccgggcccct ctgctaacca tgttcatgcc ttcttctctt     1200

tcctacagct cctgggcaac gtgctggttg ttgtgctgtc tcatcatttt ggcaaagaat     1260

taagcttata ctcgagctct agattgggaa cccgggtctc tcgaattcga gatctccacc     1320

atgcacagac ctagacgtcg tggaactcgt ccacctccac tggcactgct cgctgctctc     1380

ctcctggctg cacgtggtgc tgatgcacag gtacagctgc agcagtcggg cgcaggactg     1440

ttgaagcctt cggagaccct gtccctcacc tgcactgtct atggtggatc cttcagtatt     1500

catcactgga cctggatccg ccatccccca gggaaggggc tggagtggat tggggagatc     1560

aatcatcgtg gaagcaccaa ctacaacccg tccctcaaga gtcgagtcac catatcaata     1620

gacacgtcca agaaccagtt ctccctgaag ctgagcgctg tgaccgccgc ggacacggct     1680

gtatattact gtgcgagagg cttacgattt ttggactggt tatcgtccta ctttgactac     1740

tggggccagg gaaccctggt caccgtctcc tcagcctcca ccaagggccc atcggtcttc     1800

cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc     1860

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1920

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1980

accgtgccct ccagcagctt gggcacgaag acctacacct gcaacgtaga tcacaagccc     2040

agcaacacca aggtggacaa gagagttgag tccaaatatg gtcccccatg cccaccctgc     2100

ccagcacctg agttcctggg gggaccatca gtcttcctgt tccccccaaa acccaaggac     2160

actctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa     2220

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca     2280

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     2340

caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa aggcctcccg     2400

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     2460

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     2520

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     2580

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     2640

ctcaccgtgg acaagagcag gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     2700

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctctggg taaatgagcg     2760

gccgctaatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     2820

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     2880

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     2940

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctaccg     3000

gtcctgcagg gcccctctct tcatgtgagc aaaaggccag caaaaggcca ggaaccgtaa     3060

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     3120

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     3180

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     3240

cgcctttctc ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag     3300

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     3360

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     3420

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     3480

agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg     3540

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     3600

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     3660

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     3720

ctcacgttaa gggattttgg tcatgggcgc gcctcatact cctgcaggca tgagattatc     3780

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3840

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3900

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     3960

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     4020

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     4080

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     4140

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     4200

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     4260

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     4320

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     4380

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     4440

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     4500

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     4560

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     4620

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     4680

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     4740

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     4800

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     4860

cgtcaggtac caagcctagg cctccaaaaa agcctcctca ctacttctgg aatagctcag     4920

aggcagaggc ggcctcggcc tctgcataaa taaaaaaaat tagtcagcca tggggcggag     4980

aatgggcgga actgggcgga gttaggggcg ggatgggcgg agttaggggc gggactatgg     5040

ttgctgacta attgagatgc atgctttgca tacttctgcc tgctggggag cctggggact     5100

ttccacacct ggttgctgac taattgagat gcatgctttg catacttctg cctgctgggg     5160

agcctgggga ctttccacac cggatccacc atggatagat ccggaaagcc tgaactcacc     5220

gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag     5280

ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc     5340

ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt     5400

gcatcggccg cgctcccgat tccggaagtg cttgacattg gggagttcag cgagagcctg     5460

acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa     5520

ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt     5580

agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg     5640

cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac     5700

gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac     5760

tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac     5820

aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac     5880

gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc     5940

tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc     6000

cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct     6060

tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca     6120

caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat     6180

agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagacgcg tgctgtaagt     6240

ctgcagaaat tgatgatcta ttaaacaata aagatgtcca ctaaaatgga agtttttcct     6300

gtcatacttt gttaagaagg gtgagaacag agtacctaca ttttgaatgg aaggattgga     6360

gctacggggg tgggggtggg gtgggattag ataaatgcct gctctttact gaaggctctt     6420

tactattgct ttatgataat gtttcatagt tggatatcat aatttaaaca agcaaaacca     6480

aattaagggc cagctcattc ctcccactca tgatctatgg atctatagat ctctcgtgca     6540

gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg     6600

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     6660

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     6720

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     6780

agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     6840

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     6900

tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     6960

atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttag      7019


<210>  41
<211>  2272
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  41
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctca tgatagaagc actctactat tcgtcgaccg      600

atcctgagaa cttcagggtg agtttgggga cccttgattg ttctttcttt ttcgctattg      660

taaaattcat gttatatgga gggggcaaag ttttcagggt gttgtttaga atgggaagat      720

gtcccttgta tcaccatgga ccctcatgat aattttgttt ctttcacttt ctactctgtt      780

gacaaccatt gtctcctctt attttctttt cattttctgt aactttttcg ttaaacttta      840

gcttgcattt gtaacgaatt tttaaattca cttttgttta tttgtcagat tgtaagtact      900

ttctctaatc actttttttt caaggcaatc agggtatatt atattgtact tcagcacagt      960

tttagagaac aattgttata attaaatgat aaggtagaat atttctgcat ataaattctg     1020

gctggcgtgg aaatattctt attggtagaa acaactacac cctggtcatc atcctgcctt     1080

tctctttatg gttacaatga tatacactgt ttgagatgag gataaaatac tctgagtcca     1140

aaccgggccc ctctgctaac catgttcatg ccttcttctc tttcctacag ctcctgggca     1200

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attaagctta tactcgagct     1260

ctagattggg aacccgggtc tctcgaattc gagatctcca ccatgcacag acctagacgt     1320

cgtggaactc gtccacctcc actggcactg ctcgctgctc tcctcctggc tgcacgtggt     1380

gctgatgcag acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac     1440

agagtcacca tcacttgccg ggcgagtcag ggcattagcg attatttagc ctggtatcag     1500

cagaaaccag ggaaagttcc taacctcctg atctatgctg cgtccgcttt acaatcaggg     1560

gtcccatctc gtttcagtgg cagtggatct gggacagatt tcactctcac catcagcagc     1620

ctgcagcctg aggatgttgc aacttattac tgtcaaaatt ataacactgc cccgctcact     1680

ttcggcgggg ggaccaaggt ggaaatcaaa cgaactgtgg ctgcaccatc tgtcttcatc     1740

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat     1800

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt     1860

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc     1920

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc     1980

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttaggcggcc     2040

gctaatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct     2100

ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc     2160

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     2220

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tc             2272


<210>  42
<211>  6335
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  42
tcgagctcta gattgggaac ccgggtctct cgaattcgag atctccacca tgcacagacc       60

tagacgtcgt ggaactcgtc cacctccact ggcactgctc gctgctctcc tcctggctgc      120

acgtggtgct gatgcagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt      180

aggagacaga gtcaccatca cttgccgggc gagtcagggc attagcgatt atttagcctg      240

gtatcagcag aaaccaggga aagttcctaa cctcctgatc tatgctgcgt ccgctttaca      300

atcaggggtc ccatctcgtt tcagtggcag tggatctggg acagatttca ctctcaccat      360

cagcagcctg cagcctgagg atgttgcaac ttattactgt caaaattata acactgcccc      420

gctcactttc ggcgggggga ccaaggtgga aatcaaacga actgtggctg caccatctgt      480

cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct      540

gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca      600

atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct      660

cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga      720

agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta      780

ggcggccgct aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc      840

cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta      900

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat      960

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     1020

accggtaggg cccctctctt catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     1080

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     1140

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     1200

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     1260

gcctttctcc cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt     1320

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     1380

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     1440

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     1500

gagttcttga agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc     1560

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     1620

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     1680

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     1740

tcacgttaag ggattttggt catgggcgcg ggcatgagat tatcaaaaag gatcttcacc     1800

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1860

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1920

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1980

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta     2040

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     2100

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2160

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2220

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2280

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2340

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2400

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2460

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2520

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2580

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2640

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2700

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2760

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2820

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcag gtacacttag     2880

gcgcgccatt agagttcctg caggctacat ggtaccaagc ctaggcctcc aaaaaagcct     2940

cctcactact tctggaatag ctcagaggca gaggcggcct cggcctctgc ataaataaaa     3000

aaaattagtc agccatgggg cggagaatgg gcggaactgg gcggagttag gggcgggatg     3060

ggcggagtta ggggcgggac tatggttgct gactaattga gatgcatgct ttgcatactt     3120

ctgcctgctg gggagcctgg ggactttcca cacctggttg ctgactaatt gagatgcatg     3180

ctttgcatac ttctgcctgc tggggagcct ggggactttc cacaccggat ccaccatgga     3240

tagatccgga aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt     3300

cgacagcgtc tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt     3360

cgatgtagga gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa     3420

agatcgttat gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga     3480

cattggggag ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac     3540

gttgcaagac ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat     3600

ggatgcgatc gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca     3660

aggaatcggt caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt     3720

gtatcactgg caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga     3780

tgagctgatg ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt     3840

cggctccaac aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga     3900

ggcgatgttc ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt     3960

ggcttgtatg gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc     4020

gccgcggctc cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt     4080

tgacggcaat ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc     4140

cggagccggg actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga     4200

tggctgtgta gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc     4260

aaaggaatag acgcgtgctg taagtctgca gaaattgatg atctattaaa caataaagat     4320

gtccactaaa atggaagttt ttcctgtcat actttgttaa gaagggtgag aacagagtac     4380

ctacattttg aatggaagga ttggagctac gggggtgggg gtggggtggg attagataaa     4440

tgcctgctct ttactgaagg ctctttacta ttgctttatg ataatgtttc atagttggat     4500

atcataattt aaacaagcaa aaccaaatta agggccagct cattcctccc actcatgatc     4560

tatggatcta tagatctctc gtgcagctgg ggctctaggg ggtatcccca cgcgccctgt     4620

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     4680

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     4740

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     4800

cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga     4860

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     4920

caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg     4980

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa     5040

ttctgtggaa tgtgtgtcag ttagtcgcga tgtgtgacta gttagttatt aatagtaatc     5100

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt     5160

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta     5220

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg     5280

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga     5340

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt     5400

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg     5460

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc     5520

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg     5580

taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat     5640

aagcagagct catgatagaa gcactctact attcgtcgac cgatcctgag aacttcaggg     5700

tgagtttggg gacccttgat tgttctttct ttttcgctat tgtaaaattc atgttatatg     5760

gagggggcaa agttttcagg gtgttgttta gaatgggaag atgtcccttg tatcaccatg     5820

gaccctcatg ataattttgt ttctttcact ttctactctg ttgacaacca ttgtctcctc     5880

ttattttctt ttcattttct gtaacttttt cgttaaactt tagcttgcat ttgtaacgaa     5940

tttttaaatt cacttttgtt tatttgtcag attgtaagta ctttctctaa tcactttttt     6000

ttcaaggcaa tcagggtata ttatattgta cttcagcaca gttttagaga acaattgtta     6060

taattaaatg ataaggtaga atatttctgc atataaattc tggctggcgt ggaaatattc     6120

ttattggtag aaacaactac accctggtca tcatcctgcc tttctcttta tggttacaat     6180

gatatacact gtttgagatg aggataaaat actctgagtc caaaccgggc ccctctgcta     6240

accatgttca tgccttcttc tctttcctac agctcctggg caacgtgctg gttgttgtgc     6300

tgtctcatca ttttggcaaa gaattaagct tatac                                6335


<210>  43
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Xaa Asp Val Trp Gly Gln Gly Thr Thr Val Xaa Val Ser Ser Ala Ser 
1               5                   10                  15      


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Xaa Ser Xaa Ser Thr 
            20                  25                  30          


Ser Xaa Xaa Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        35                  40                  45              


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    50                  55                  60                  


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
65                  70                  75                  80  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Xaa Thr Tyr Xaa 
                85                  90                  95      


Cys Asn Val Xaa His Lys Pro Ser Asn Thr Lys Val Asp Lys Xaa Val 
            100                 105                 110         


Glu Xaa Lys 
        115 


<210>  44
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (109)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (134)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Xaa Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Xaa Glu 
        35                  40                  45              


Asp Pro Glu Val Xaa Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    50                  55                  60                  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Xaa Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Xaa Leu Pro Xaa Xaa Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        115                 120                 125             


Thr Leu Pro Pro Ser Xaa Xaa Glu Xaa Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Xaa Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Xaa Gly Asn Val Phe Ser Cys Ser Val Met His 
        195                 200                 205             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Xaa 
    210                 215                 220                 


Gly 
225 


<210>  45
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Ser Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Xaa 
1               5                   10                  15      


Leu Leu Ile Tyr Xaa Xaa Ser Xaa Xaa Xaa Xaa Gly Val Pro Xaa Arg 
            20                  25                  30          


Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Xaa 
        35                  40                  45              


Leu Xaa Pro Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln 
    50                  55                  60  


<210>  46
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  46

Thr Phe Gly Xaa Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
1               5                   10                  15      


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
            20                  25                  30          


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
        35                  40                  45              


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
    50                  55                  60                  


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
65                  70                  75                  80  


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
                85                  90                  95      


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
            100                 105                 110         


Phe Asn Arg Gly Glu Cys 
        115             


