                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       Ho, Mitchell
       Phung, Yen T.
       Gao, Wei
       Zhang, Yifan
 
<120>  HIGH-AFFINITY MONOCLONAL ANTIBODIES TO GLYPICAN-3 AND USE THEREOF

<130>  4239-89154-02

<150>  US 61/654,232
<151>  2012-06-01

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            100                 105                 110         


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
        115                 120                 125             


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg 
    130                 135                 140                 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln 
145                 150                 155                 160 


Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu 
                165                 170                 175     


Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln 
            180                 185                 190         


Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala 
        195                 200                 205             


Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg 
    210                 215                 220                 


Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu 
225                 230                 235                 240 


Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp 
            260                 265                 270         


Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu 
        275                 280                 285             


Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro 
    290                 295                 300                 


Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro 
305                 310                 315                 320 


Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro 
                325                 330                 335     


Gly Lys Pro Pro Arg Glu Asp Leu Lys 
            340                 345 


<210>  2
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu 
        195                 200                 205             


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  3
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Gly Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu 
        195                 200                 205             


Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  4
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  Xaa = Gly, Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (209)..(209)
<223>  Xaa = Gly, Ala or Ser

<400>  4

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Xaa Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Xaa Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Xaa Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Xaa Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Xaa Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Xaa Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Xaa Glu 
        195                 200                 205             


Xaa Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Pro Thr Gly Ala Glu 
1               5                   10                  15      


Phe Leu Gly Asp Gly Gly Ala Val Ser Phe Ser Thr Arg Gly Thr Gln 
            20                  25                  30          


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu 
        35                  40                  45              


Gly Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala 
    50                  55                  60                  


Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp 
65                  70                  75                  80  


Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr 
                85                  90                  95      


Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn 
            100                 105                 110         


Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe 
        115                 120                 125             


Tyr Ala Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val 
    130                 135                 140                 


Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr 
145                 150                 155                 160 


Gly Pro Glu Glu Ser Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro 
                165                 170                 175     


Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro 
            180                 185                 190         


Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Ser Glu 
        195                 200                 205             


Ala Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro 
    210                 215                 220                 


Pro Arg Glu Asp Leu Lys 
225                 230 


<210>  6
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu 
1               5                   10                  15      


Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala 
            20                  25                  30          


Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val 
        35                  40                  45              


His Ser 
    50  


<210>  7
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gaggtgcagc ttgttgagac tggtggagga atggtgcagc ctgaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagaatgcca tgaattgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaaata aaactaataa ttatgcaaca      180

tattatgccg attcagtgaa agccaggttt accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaatt gaggacacag ccatgtacta ttgtgtggct      300

ggtaactcgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  9
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gacattgtga tgtcacagtc tccatcctcc ctagttgtgt caattggaga gaaggttact       60

atgacctgca agtccagtca gagcctttta tatagcagca atcaaaagaa ctacttggcc      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tttactgggc atccagtagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat      300

ccgctcacgt tcggtgctgg gaccaagttg gagctgaaa                             339


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  11
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gaggtgcagc ttgttgagac tggcggagga ttggtgcagc ctgaagggtc attgaaactc       60

tcatgtgcaa cgtctggatt caacttcaat accaatgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc gtaagaaata aaactaataa ttatgcaaca      180

tattatgccg attcagtgaa agacaggttc accatctcca gagatgattc acaaagaatg      240

gtctttctgc aaatgaataa cttgaaaact gaggacacag ccatctatta ctgtgtggcg      300

gggaactcgt ttgcttattg gggccaaggg actctggtca ctgtctctcc t               351


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Asn Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Val Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Arg Met 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Pro 
        115         


<210>  13
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gagggttact       60

atgaactgca agtccagtca gagtctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtgtatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Val Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  15
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
gaggtgcagc ttgttggaag tggtggagga ttggtgcagc ctgaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaag accaatgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaaata aaactaataa ttatgcaaca      180

tattatgccg actcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaagacacag ccatgtattt ctgtgtggcc      300

ggtaactcgt ttgcttactg gggccagggg actctggtca ctgtctctgc a               351


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Glu Val Gln Leu Val Gly Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Phe Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  17
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

gtgaactgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atcaactagg      180

gaatatgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Val Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Tyr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  19
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gaggtccagc ttgttgagac tggtggagga ttggtgcagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat accaatgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttgcaatg ggttgctcgc gtaagaaata aaactaataa ttatgcaaca      180

tattatgccg attccgtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaagacacgg ccatttatta ctgtgtgggg      300

ggtaactcgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  20
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Arg Val Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Val Gly Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  21
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
gacattgtga tgtcccagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccacc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccactcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  23
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
gacattgtga tgtcccagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccacc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatatctat      300

ccactcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ile Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  25
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gacattgtga tgtcccagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtaaca atcaaaagaa ctacttggcc      120

tggtaccacc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccactcacgt tcggtgctgg gaccaagctg gaaataaaa                             339


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr His Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  27
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
atggaggtgc agcttgttga gactggtgga ggaatggtgc agcctgaagg gtcattgaaa       60

ctctcatgtg cagcctctgg attcaccttc aataagaatg ccatgaattg ggtccgccag      120

gctccaggaa agggtttgga atgggttgct cgcataagaa ataaaactaa taattatgca      180

acatattatg ccgattcagt gaaagccagg tttaccatct ccagagatga ttcacaaagc      240

atgctctatc tgcaaatgaa caacttgaaa attgaggaca cagccatgta ctattgtgtg      300

gctggtaact cgtttgctta ctggggccaa gggactctgg tcactgtctc tgcaggcgga      360

ggcggatcag gtggtggcgg atctggaggt ggcggaagcg acattgtgat gtcacagtct      420

ccatcctccc tagttgtgtc aattggagag aaggttacta tgacctgcaa gtccagtcag      480

agccttttat atagcagcaa tcaaaagaac tacttggcct ggtaccaaca gaaaccaggg      540

cagtctccta aactgctgat ttactgggca tccagtaggg aatctggggt ccctgatcgc      600

ttcacaggca gtggatctgg gacagatttc actctcacca tcagcagtgt gaaggctgaa      660

gacctggcag tttattactg tcagcaatat tataactatc cgctcacgtt cggtgctggg      720

accaagttgg agctgaaagc ttccggaggt cccgagggcg gcagcctggc cgcgctgacc      780

gcgcaccagg cttgccacct gccgctggag actttcaccc gtcatcgcca gccgcgcggc      840

tgggaacaac tggagcagtg cggctatccg gtgcagcggc tggtcgccct ctacctggcg      900

gcgcggctgt cgtggaacca ggtcgaccag gtgatccgca acgccctggc cagccccggc      960

agcggcggcg acctgggcga agcgatccgc gagcagccgg agcaggcccg tctggccctg     1020

accctggccg ccgccgagag cgagcgcttc gtccggcagg gcaccggcaa cgacgaggcc     1080

ggcgcggcca acggcccggc ggacagcggc gacgccctgc tggagcgcaa ctatcccact     1140

ggcgcggagt tcctcggcga cggcggcgac gtcagcttca gcacccgcgg cacgcagaac     1200

tggacggtgg agcggctgct ccaggcgcac cgccaactgg aggagcgcgg ctatgtgttc     1260

gtcggctacc acggcacctt cctcgaagcg gcgcaaagca tcgtcttcgg cggggtgcgc     1320

gcgcgcagcc aggacctcga cgcgatctgg cgcggtttct atatcgccgg cgatccggcg     1380

ctggcctacg gctacgccca ggaccaggaa cccgacgcac gcggccggat ccgcaacggt     1440

gccctgctgc gggtctatgt gccgcgctcg agcctgccgg gcttctaccg caccagcctg     1500

accctggccg cgccggaggc ggcgggcgag gtcgaacggc tgatcggcca tccgctgccg     1560

ctgcgcctgg acgccatcac cggccccgag gaggaaggcg ggcgcctgga gaccattctc     1620

ggctggccgc tggccgagcg caccgtggtg attccctcgg cgatccccac cgacccgcgc     1680

aacgtcggcg gcgacctcga cccgtccagc atccccgaca aggaacaggc gatcagcgcc     1740

ctgccggact acgccagcca gcccggcaaa ccgccgcgcg aggacctgaa gtaactg        1797


<210>  28
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
            20                  25                  30          


Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser 
65                  70                  75                  80  


Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Val Val Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp 
        355                 360                 365             


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
    370                 375                 380                 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
385                 390                 395                 400 


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
                405                 410                 415     


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
            420                 425                 430         


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
        435                 440                 445             


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
    450                 455                 460                 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
465                 470                 475                 480 


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
                485                 490                 495     


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
            500                 505                 510         


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
        515                 520                 525             


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
    530                 535                 540                 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
545                 550                 555                 560 


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
                565                 570                 575     


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
            580                 585                 590         


Arg Glu Asp Leu Lys 
        595         


<210>  29
<211>  613
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  29

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210>  30
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
atggaggtgc agcttgttgg aagtggtgga ggattggtgc agcctgaagg gtcattgaaa       60

ctctcatgtg cagcctctgg attcaccttc aagaccaatg ccatgaactg ggtccgccag      120

gctccaggaa agggtttgga atgggttgct cgcataagaa ataaaactaa taattatgca      180

acatattatg ccgactcagt gaaagacagg ttcaccatct ccagagatga ttcacaaagc      240

atgctctatc tgcaaatgaa caacttgaaa actgaagaca cagccatgta tttctgtgtg      300

gccggtaact cgtttgctta ctggggccag gggactctgg tcactgtctc tgcaggcgga      360

ggcggatcag gtggtggcgg atctggaggt ggcggaagcg acattgtgat gtcacagtct      420

ccatcctccc tagctgtgtc agttggagag aaggttactg tgaactgcaa gtccagtcag      480

agccttttat atagtaacaa tcaaaagaac tacttggcct ggtaccagca gaaaccaggg      540

cagtctccta aactgctgat ttactgggca tcaactaggg aatatggggt ccctgatcgc      600

ttcacaggca gtggatctgg gacagatttc actctcacca tcagcagtgt gaaggctgaa      660

gacctggcag tttattactg tcagcaatat tataactatc cgctcacgtt cggtgctggg      720

accaagctgg agctgaaagc ttccggaggt cccgagggcg gcagcctggc cgcgctgacc      780

gcgcaccagg cttgccacct gccgctggag actttcaccc gtcatcgcca gccgcgcggc      840

tgggaacaac tggagcagtg cggctatccg gtgcagcggc tggtcgccct ctacctggcg      900

gcgcggctgt cgtggaacca ggtcgaccag gtgatccgca acgccctggc cagccccggc      960

agcggcggcg acctgggcga agcgatccgc gagcagccgg agcaggcccg tctggccctg     1020

accctggccg ccgccgagag cgagcgcttc gtccggcagg gcaccggcaa cgacgaggcc     1080

ggcgcggcca acggcccggc ggacagcggc gacgccctgc tggagcgcaa ctatcccact     1140

ggcgcggagt tcctcggcga cggcggcgac gtcagcttca gcacccgcgg cacgcagaac     1200

tggacggtgg agcggctgct ccaggcgcac cgccaactgg aggagcgcgg ctatgtgttc     1260

gtcggctacc acggcacctt cctcgaagcg gcgcaaagca tcgtcttcgg cggggtgcgc     1320

gcgcgcagcc aggacctcga cgcgatctgg cgcggtttct atatcgccgg cgatccggcg     1380

ctggcctacg gctacgccca ggaccaggaa cccgacgcac gcggccggat ccgcaacggt     1440

gccctgctgc gggtctatgt gccgcgctcg agcctgccgg gcttctaccg caccagcctg     1500

accctggccg cgccggaggc ggcgggcgag gtcgaacggc tgatcggcca tccgctgccg     1560

ctgcgcctgg acgccatcac cggccccgag gaggaaggcg ggcgcctgga gaccattctc     1620

ggctggccgc tggccgagcg caccgtggtg attccctcgg cgatccccac cgacccgcgc     1680

aacgtcggcg gcgacctcga cccgtccagc atccccgaca aggaacaggc gatcagcgcc     1740

ctgccggact acgccagcca gcccggcaaa ccgccgcgcg aggacctgaa gtaactgccg     1800


<210>  31
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Glu Val Gln Leu Val Gly Ser Gly Gly Gly Leu Val Gln Pro Glu 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr 
            20                  25                  30          


Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser 
65                  70                  75                  80  


Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Phe Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ala Val Ser Val Gly Glu Lys Val Thr Val Asn Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Tyr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp 
        355                 360                 365             


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
    370                 375                 380                 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
385                 390                 395                 400 


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
                405                 410                 415     


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
            420                 425                 430         


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
        435                 440                 445             


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
    450                 455                 460                 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
465                 470                 475                 480 


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
                485                 490                 495     


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
            500                 505                 510         


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
        515                 520                 525             


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
    530                 535                 540                 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
545                 550                 555                 560 


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
                565                 570                 575     


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
            580                 585                 590         


Arg Glu Asp Leu Lys 
        595         


<210>  32
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
atggaggtgc agcttgttga gactggtgga ggattggtgc agcctaaagg gtcattgaaa       60

ctctcatgtg cagcctctgg attcaccttc aataccaatg ccatgaactg ggtccgccag      120

gctccaggaa agggtttgca atgggttgct cgcgtaagaa ataaaactaa taattatgca      180

acatattatg ccgattccgt gaaagacagg ttcaccatct ccagagatga ttcacaaagc      240

atgctctatc tgcaaatgaa caacttgaaa actgaagaca cggccattta ttactgtgtg      300

gggggtaact cgtttgctta ctggggccaa gggactctgg tcactgtctc tgcaggcgga      360

ggcggatcag gtggtggcgg atctggaggt ggcggaagcg acattgtgat gtcccagtct      420

ccatcctccc tagctgtgtc agttggagag aaggttacta tgagctgcaa gtccagtcag      480

agccttttat atagtaacaa tcaaaagaac tacttggcct ggtaccacca gaaaccaggg      540

cagtctccta aactgctgat ttactgggca tccactaggg aatctggggt ccctgatcgc      600

ttcacaggca gtggatctgg gacagatttc actctcacca tcagcagtgt gaaggctgaa      660

gacctggcag tttattactg tcagcaatat tatagctatc cactcacgtt cggtgctggg      720

accaagctgg agctgaaagc ttccggaggt cccgagggcg gcagcctggc cgcgctgacc      780

gcgcaccagg cttgccacct gccgctggag actttcaccc gtcatcgcca gccgcgcggc      840

tgggaacaac tggagcagtg cggctatccg gtgcagcggc tggtcgccct ctacctggcg      900

gcgcggctgt cgtggaacca ggtcgaccag gtgatccgca acgccctggc cagccccggc      960

agcggcggcg acctgggcga agcgatccgc gagcagccgg agcaggcccg tctggccctg     1020

accctggccg ccgccgagag cgagcgcttc gtccggcagg gcaccggcaa cgacgaggcc     1080

ggcgcggcca acggcccggc ggacagcggc gacgccctgc tggagcgcaa ctatcccact     1140

ggcgcggagt tcctcggcga cggcggcgac gtcagcttca gcacccgcgg cacgcagaac     1200

tggacggtgg agcggctgct ccaggcgcac cgccaactgg aggagcgcgg ctatgtgttc     1260

gtcggctacc acggcacctt cctcgaagcg gcgcaaagca tcgtcttcgg cggggtgcgc     1320

gcgcgcagcc aggacctcga cgcgatctgg cgcggtttct atatcgccgg cgatccggcg     1380

ctggcctacg gctacgccca ggaccaggaa cccgacgcac gcggccggat ccgcaacggt     1440

gccctgctgc gggtctatgt gccgcgctcg agcctgccgg gcttctaccg caccagcctg     1500

accctggccg cgccggaggc ggcgggcgag gtcgaacggc tgatcggcca tccgctgccg     1560

ctgcgcctgg acgccatcac cggccccgag gaggaaggcg ggcgcctgga gaccattctc     1620

ggctggccgc tggccgagcg caccgtggtg attccctcgg cgatccccac cgacccgcgc     1680

aacgtcggcg gcgacctcga cccgtccagc atccccgaca aggaacaggc gatcagcgcc     1740

ctgccggact acgccagcca gcccggcaaa ccgccgcgcg aggacctgaa gtaactgccg     1800


<210>  33
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr 
            20                  25                  30          


Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp 
        35                  40                  45              


Val Ala Arg Val Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser 
65                  70                  75                  80  


Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Ile 
                85                  90                  95      


Tyr Tyr Cys Val Gly Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr His 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp 
        355                 360                 365             


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
    370                 375                 380                 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
385                 390                 395                 400 


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
                405                 410                 415     


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
            420                 425                 430         


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
        435                 440                 445             


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
    450                 455                 460                 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
465                 470                 475                 480 


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
                485                 490                 495     


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
            500                 505                 510         


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
        515                 520                 525             


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
    530                 535                 540                 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
545                 550                 555                 560 


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
                565                 570                 575     


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
            580                 585                 590         


Arg Glu Asp Leu Lys 
        595         


<210>  34
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
atggaggtgc agcttgttga gactggcgga ggattggtgc agcctgaagg gtcattgaaa       60

ctctcatgtg caacgtctgg attcaacttc aataccaatg ccatgaactg ggtccgccag      120

gctccaggaa agggtttgga atgggttgct cgcgtaagaa ataaaactaa taattatgca      180

acatattatg ccgattcagt gaaagacagg ttcaccatct ccagagatga ttcacaaaga      240

atggtctttc tgcaaatgaa taacttgaaa actgaggaca cagccatcta ttactgtgtg      300

gcggggaact cgtttgctta ttggggccaa gggactctgg tcactgtctc tcctggcgga      360

ggcggatcag gtggtggcgg atctggaggt ggcggaagcg acattgtgat gtcacagtct      420

ccatcctccc tagctgtgtc agttggagag agggttacta tgaactgcaa gtccagtcag      480

agtcttttat atagtagcaa tcaaaagaac tacttggcct ggtaccagca gaaaccaggg      540

cagtctccta aactgctgat ttactgggca tccactaggg aatctggggt ccctgatcgc      600

ttcacaggca gtgtatctgg gacagatttc actctcacca tcagcagtgt gaaggctgaa      660

gacctggcag tttattactg tcagcaatat tataactatc cgctcacgtt cggtgctggg      720

accaagctgg agctgaaagc ttccggaggt cccgagggcg gcagcctggc cgcgctgacc      780

gcgcaccagg cttgccacct gccgctggag actttcaccc gtcatcgcca gccgcgcggc      840

tgggaacaac tggagcagtg cggctatccg gtgcagcggc tggtcgccct ctacctggcg      900

gcgcggctgt cgtggaacca ggtcgaccag gtgatccgca acgccctggc cagccccggc      960

agcggcggcg acctgggcga agcgatccgc gagcagccgg agcaggcccg tctggccctg     1020

accctggccg ccgccgagag cgagcgcttc gtccggcagg gcaccggcaa cgacgaggcc     1080

ggcgcggcca acggcccggc ggacagcggc gacgccctgc tggagcgcaa ctatcccact     1140

ggcgcggagt tcctcggcga cggcggcgac gtcagcttca gcacccgcgg cacgcagaac     1200

tggacggtgg agcggctgct ccaggcgcac cgccaactgg aggagcgcgg ctatgtgttc     1260

gtcggctacc acggcacctt cctcgaagcg gcgcaaagca tcgtcttcgg cggggtgcgc     1320

gcgcgcagcc aggacctcga cgcgatctgg cgcggtttct atatcgccgg cgatccggcg     1380

ctggcctacg gctacgccca ggaccaggaa cccgacgcac gcggccggat ccgcaacggt     1440

gccctgctgc gggtctatgt gccgcgctcg agcctgccgg gcttctaccg caccagcctg     1500

accctggccg cgccggaggc ggcgggcgag gtcgaacggc tgatcggcca tccgctgccg     1560

ctgcgcctgg acgccatcac cggccccgag gaggaaggcg ggcgcctgga gaccattctc     1620

ggctggccgc tggccgagcg caccgtggtg attccctcgg cgatccccac cgacccgcgc     1680

aacgtcggcg gcgacctcga cccgtccagc atccccgaca aggaacaggc gatcagcgcc     1740

ctgccggact acgccagcca gcccggcaaa ccgccgcgcg aggacctgaa gtaactg        1797


<210>  35
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Glu 
1               5                   10                  15      


Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Asn Phe Asn Thr 
            20                  25                  30          


Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Arg Val Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Arg 
65                  70                  75                  80  


Met Val Phe Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Ile 
                85                  90                  95      


Tyr Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ala Val Ser Val Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
            180                 185                 190         


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Val Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp 
        355                 360                 365             


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
    370                 375                 380                 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
385                 390                 395                 400 


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
                405                 410                 415     


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
            420                 425                 430         


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
        435                 440                 445             


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
    450                 455                 460                 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
465                 470                 475                 480 


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
                485                 490                 495     


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
            500                 505                 510         


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
        515                 520                 525             


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
    530                 535                 540                 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
545                 550                 555                 560 


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
                565                 570                 575     


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
            580                 585                 590         


Arg Glu Asp Leu Lys 
        595         


<210>  36
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
gaggtgcagc ttgttggaag tggtggagga ttggtgcagc ctgaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaag accaatgcca tgaactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaaata aaactaataa ttatgcaaca      180

tattatgccg actcagtgaa agacaggttc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaact gaagacacag ccatgtattt ctgtgtggcc      300

ggtaactcgt ttgcttactt gggccagggg actctggtca ctgtctctgc a               351


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Glu Val Gln Leu Val Gly Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Phe Cys Val Ala Gly Asn Ser Phe Ala Tyr Leu Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Lys or Asn

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Thr or Lys

<400>  38

Gly Phe Xaa Phe Xaa Xaa Asn Ala 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Ile or Val

<400>  39

Xaa Arg Asn Lys Thr Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Ala or Gly

<400>  40

Val Xaa Gly Asn Ser Phe Ala Tyr 
1               5               


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa - Thr or Lys

<400>  41

Xaa Asn Ala Met Asn 
1               5   


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Asp or Ala

<400>  42

Arg Xaa Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Xaa 
            


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Gly Asn Ser Phe Ala Tyr 
1               5       


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Ser, Ile or Asn

<400>  45

Gln Gln Tyr Tyr Xaa Tyr Pro Leu Thr 
1               5                   


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Ser or Tyr

<400>  47

Trp Ala Ser Xaa Arg Glu Xaa 
1               5           


