

SEQUENCE LISTING

<110>  DUCHATEAU PHILIPPE
	 JUILLERAT ALEXANDRE 

<120>  New transcription Activator-Like Effector (TALE) fusion protein	
<130>  400242WO
<160>  91   
<170>  PatentIn version 3.5

<210>  1

<211>  1164
<212>  PRT
<213>  AvrBs3

<220>

<400>  1
Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Pro Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val 
            20                  25                  30          


Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His 
                85                  90                  95      


Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    290                 295                 300                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
305                 310                 315                 320 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                325                 330                 335     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            340                 345                 350         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        355                 360                 365             


Ser Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    370                 375                 380                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
385                 390                 395                 400 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                405                 410                 415     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
            420                 425                 430         


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
        435                 440                 445             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    450                 455                 460                 


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
465                 470                 475                 480 


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
                485                 490                 495     


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
            500                 505                 510         


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        515                 520                 525             


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
    530                 535                 540                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
545                 550                 555                 560 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
                565                 570                 575     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            580                 585                 590         


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        595                 600                 605             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    610                 615                 620                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
625                 630                 635                 640 


Ser Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                645                 650                 655     


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            660                 665                 670         


Ser Asn Ser Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        675                 680                 685             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    690                 695                 700                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
705                 710                 715                 720 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                725                 730                 735     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            740                 745                 750         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        755                 760                 765             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    770                 775                 780                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
785                 790                 795                 800 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
                805                 810                 815     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            820                 825                 830         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
        835                 840                 845             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    850                 855                 860                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
865                 870                 875                 880 


Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 
                885                 890                 895     


Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys 
            900                 905                 910         


Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His 
        915                 920                 925             


Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr 
    930                 935                 940                 


Ser His Arg Val Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe 
945                 950                 955                 960 


Phe Gln Cys His Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr 
                965                 970                 975     


Gln Phe Gly Met Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val 
            980                 985                 990         


Gly Val Thr Glu Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser 
        995                 1000                1005            


Gln Arg Trp Asp Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys 
    1010                1015                1020                


Pro Ser Pro Thr Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala 
1025                1030                1035                1040


Phe Ala Asp Ser Leu Glu Arg Asp Leu Asp Ala Pro Ser Pro Met His 
                1045                1050                1055    


Glu Gly Asp Gln Thr Arg Ala Ser Ser Arg Lys Arg Ser Arg Ser Asp 
            1060                1065                1070        


Arg Ala Val Thr Gly Pro Ser Ala Gln Gln Ser Phe Glu Val Arg Val 
        1075                1080                1085            


Pro Glu Gln Arg Asp Ala Leu His Leu Pro Leu Ser Trp Arg Val Lys 
    1090                1095                1100                


Arg Pro Arg Thr Ser Ile Gly Gly Gly Leu Pro Asp Pro Gly Thr Pro 
1105                1110                1115                1120


Thr Ala Ala Asp Leu Ala Ala Ser Ser Thr Val Met Arg Glu Gln Asp 
                1125                1130                1135    


Glu Asp Pro Phe Ala Gly Ala Ala Asp Asp Phe Pro Ala Phe Asn Glu 
            1140                1145                1150        


Glu Glu Leu Ala Trp Leu Met Glu Leu Leu Pro Gln 
        1155                1160                


<210>  2

<211>  1893
<212>  DNA
<213>  pCLS13597

<220>

<400>  2
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tccagctggt gaagtccgag ctggaggaga agaaatccga gttgaggcac    120
aagctgaagt acgtgcccca cgagtacatc gagctgatcg agatcgcccg gaacagcacc    180
caggaccgta tcctggagat gaaggtgatg gagttcttca tgaaggtgta cggctacagg    240
ggcaagcacc tgggcggctc caggaagccc gacggcgcca tctacaccgt gggctccccc    300
atcgactacg gcgtgatcgt ggacaccaag gcctactccg gcggctacaa cctgcccatc    360
ggccaggccg acgaaatgca gaggtacgtg gaggagaacc agaccaggaa caagcacatc    420
aaccccaacg agtggtggaa ggtgtacccc tccagcgtga ccgagttcaa gttcctgttc    480
gtgtccggcc acttcaaggg caactacaag gcccagctga ccaggctgaa ccacatcacc    540
aactgcaacg gcgccgtgct gtccgtggag gagctcctga tcggcggcga gatgatcaag    600
gccggcaccc tgaccctgga ggaggtgagg aggaagttca acaacggcga gatcaacttc    660
gctagctctg gaggttcagg ttctacggct gggtttatcg ccgatctacg cacgctcggc    720
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    780
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    840
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    900
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    960
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa   1020
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc   1080
aatgcactga cgggtgcccc gctcaacttg accggagacg cccgggggat caggtcacgt   1140
gcgtctcgga gcattgttgc ccagttatct cgccctgatc cggcgttggc cgcgttgacc   1200
aacgaccacc tcgtcgcctt ggcctgcctc ggcgggcgtc ctgcgctgga tgcagtgaaa   1260
aagggattgg gggatcctat cagccgttcc cagctggtga agtccgagct ggaggagaag   1320
aaatccgagt tgaggcacaa gctgaagtac gtgccccacg agtacatcga gctgatcgag   1380
atcgcccgga acagcaccca ggaccgtatc ctggagatga aggtgatgga gttcttcatg   1440
aaggtgtacg gctacagggg caagcacctg ggcggctcca ggaagcccga cggcgccatc   1500
tacaccgtgg gctcccccat cgactacggc gtgatcgtgg acaccaaggc ctactccggc   1560
ggctacaacc tgcccatcgg ccaggccgac gaaatgcaga ggtacgtgga ggagaaccag   1620
accaggaaca agcacatcaa ccccaacgag tggtggaagg tgtacccctc cagcgtgacc   1680
gagttcaagt tcctgttcgt gtccggccac ttcaagggca actacaaggc ccagctgacc   1740
aggctgaacc acatcaccaa ctgcaacggc gccgtgctgt ccgtggagga gctcctgatc   1800
ggcggcgaga tgatcaaggc cggcaccctg accctggagg aggtgaggag gaagttcaac   1860
aacggcgaga tcaacttcgc ggccgactga taa                                1893


<210>  3

<211>  2349
<212>  DNA
<213>  pCLS12843

<220>

<400>  3
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tccagctggt gaagtccgag ctggaggaga agaaatccga gttgaggcac    120
aagctgaagt acgtgcccca cgagtacatc gagctgatcg agatcgcccg gaacagcacc    180
caggaccgta tcctggagat gaaggtgatg gagttcttca tgaaggtgta cggctacagg    240
ggcaagcacc tgggcggctc caggaagccc gacggcgcca tctacaccgt gggctccccc    300
atcgactacg gcgtgatcgt ggacaccaag gcctactccg gcggctacaa cctgcccatc    360
ggccaggccg acgaaatgca gaggtacgtg gaggagaacc agaccaggaa caagcacatc    420
aaccccaacg agtggtggaa ggtgtacccc tccagcgtga ccgagttcaa gttcctgttc    480
gtgtccggcc acttcaaggg caactacaag gcccagctga ccaggctgaa ccacatcacc    540
aactgcaacg gcgccgtgct gtccgtggag gagctcctga tcggcggcga gatgatcaag    600
gccggcaccc tgaccctgga ggaggtgagg aggaagttca acaacggcga gatcaacttc    660
gctagctctg gaggttcagg ttctacggct gggtttatcg ccgaccccat tcgttcgcgc    720
acaccaagtc ctgcccgcga gcttctgccc ggaccccaac ccgatggggt tcagccgact    780
gcagatcgtg gggtgtctcc gcctgccggc ggccccctgg atggcttgcc ggctcggcgg    840
acgatgtccc ggacccggct gccatctccc cctgccccct cacctgcgtt ctcggcgggc    900
agcttcagtg acctgttacg tcagttcgat ccgtcacttt ttaatacatc gctttttgat    960
tcattgcctc ccttcggcgc tcaccataca gaggctgcca caggcgagtg ggatgaggtg   1020
caatcgggtc tgcgggcagc cgacgccccc ccacccacca tgcgcgtggc tgtcactgcc   1080
gcgcggcccc cgcgcgccaa gccggcgccg cgacgacgtg ctgcgcaacc ctccgacgct   1140
tcgccggcgg cgcaggtgga tctacgcacg ctcggctaca gccagcagca acaggagaag   1200
atcaaaccga aggttcgttc gacagtggcg cagcaccacg aggcactggt cggccacggg   1260
tttacacacg cgcacatcgt tgcgttaagc caacacccgg cagcgttagg gaccgtcgct   1320
gtcaagtatc aggacatgat cgcagcgttg ccagaggcga cacacgaagc gatcgttggc   1380
gtcggcaaac agtggtccgg cgcacgcgct ctggaggcct tgctcacggt ggcgggagag   1440
ttgagaggtc caccgttaca gttggacaca ggccaacttc tcaagattgc aaaacgtggc   1500
ggcgtgaccg cagtggaggc agtgcatgca tggcgcaatg cactgacggg tgccccgctc   1560
aacttgaccg gagacgcccg ggggatcagg tcacgtgcgt ctcggagcat tgttgcccag   1620
ttatctcgcc ctgatccggc gttggccgcg ttgaccaacg accacctcgt cgccttggcc   1680
tgcctcggcg ggcgtcctgc gctggatgca gtgaaaaagg gattggggga tcctatcagc   1740
cgttcccagc tggtgaagtc cgagctggag gagaagaaat ccgagttgag gcacaagctg   1800
aagtacgtgc cccacgagta catcgagctg atcgagatcg cccggaacag cacccaggac   1860
cgtatcctgg agatgaaggt gatggagttc ttcatgaagg tgtacggcta caggggcaag   1920
cacctgggcg gctccaggaa gcccgacggc gccatctaca ccgtgggctc ccccatcgac   1980
tacggcgtga tcgtggacac caaggcctac tccggcggct acaacctgcc catcggccag   2040
gccgacgaaa tgcagaggta cgtggaggag aaccagacca ggaacaagca catcaacccc   2100
aacgagtggt ggaaggtgta cccctccagc gtgaccgagt tcaagttcct gttcgtgtcc   2160
ggccacttca agggcaacta caaggcccag ctgaccaggc tgaaccacat caccaactgc   2220
aacggcgccg tgctgtccgt ggaggagctc ctgatcggcg gcgagatgat caaggccggc   2280
accctgaccc tggaggaggt gaggaggaag ttcaacaacg gcgagatcaa cttcgcggcc   2340
gactgataa                                                           2349


<210>  4

<211>  1260
<212>  DNA
<213>  pCLS8422

<220>

<400>  4
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgaccggag acgcccgggg gatcaggtca cgtgcgtctc ggagcattgt tgcccagtta    540
tctcgccctg atccggcgtt ggccgcgttg accaacgacc acctcgtcgc cttggcctgc    600
ctcggcgggc gtcctgcgct ggatgcagtg aaaaagggat tgggggatcc tatcagccgt    660
tcccagctgg tgaagtccga gctggaggag aagaaatccg agttgaggca caagctgaag    720
tacgtgcccc acgagtacat cgagctgatc gagatcgccc ggaacagcac ccaggaccgt    780
atcctggaga tgaaggtgat ggagttcttc atgaaggtgt acggctacag gggcaagcac    840
ctgggcggct ccaggaagcc cgacggcgcc atctacaccg tgggctcccc catcgactac    900
ggcgtgatcg tggacaccaa ggcctactcc ggcggctaca acctgcccat cggccaggcc    960
gacgaaatgc agaggtacgt ggaggagaac cagaccagga acaagcacat caaccccaac   1020
gagtggtgga aggtgtaccc ctccagcgtg accgagttca agttcctgtt cgtgtccggc   1080
cacttcaagg gcaactacaa ggcccagctg accaggctga accacatcac caactgcaac   1140
ggcgccgtgc tgtccgtgga ggagctcctg atcggcggcg agatgatcaa ggccggcacc   1200
ctgaccctgg aggaggtgag gaggaagttc aacaacggcg agatcaactt cgcggccgct   1260


<210>  5

<211>  1716
<212>  DNA
<213>  pCLS8426

<220>

<400>  5
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga ccggagacgc ccgggggatc    960
aggtcacgtg cgtctcggag cattgttgcc cagttatctc gccctgatcc ggcgttggcc   1020
gcgttgacca acgaccacct cgtcgccttg gcctgcctcg gcgggcgtcc tgcgctggat   1080
gcagtgaaaa agggattggg ggatcctatc agccgttccc agctggtgaa gtccgagctg   1140
gaggagaaga aatccgagtt gaggcacaag ctgaagtacg tgccccacga gtacatcgag   1200
ctgatcgaga tcgcccggaa cagcacccag gaccgtatcc tggagatgaa ggtgatggag   1260
ttcttcatga aggtgtacgg ctacaggggc aagcacctgg gcggctccag gaagcccgac   1320
ggcgccatct acaccgtggg ctcccccatc gactacggcg tgatcgtgga caccaaggcc   1380
tactccggcg gctacaacct gcccatcggc caggccgacg aaatgcagag gtacgtggag   1440
gagaaccaga ccaggaacaa gcacatcaac cccaacgagt ggtggaaggt gtacccctcc   1500
agcgtgaccg agttcaagtt cctgttcgtg tccggccact tcaagggcaa ctacaaggcc   1560
cagctgacca ggctgaacca catcaccaac tgcaacggcg ccgtgctgtc cgtggaggag   1620
ctcctgatcg gcggcgagat gatcaaggcc ggcaccctga ccctggagga ggtgaggagg   1680
aagttcaaca acggcgagat caacttcgcg gccgct                             1716


<210>  6

<211>  2219
<212>  DNA
<213>  pCLS7183

<220>

<400>  6
ccatggccga ccccattcgt tcgcgcacac caagtcctgc ccgcgagctt ctgcccggac     60
cccaacccga tggggttcag ccgactgcag atcgtggggt gtctccgcct gccggcggcc    120
ccctggatgg cttgccggct cggcggacga tgtcccggac ccggctgcca tctccccctg    180
ccccctcacc tgcgttctcg gcgggcagct tcagtgacct gttacgtcag ttcgatccgt    240
cactttttaa tacatcgctt tttgattcat tgcctccctt cggcgctcac catacagagg    300
ctgccacagg cgagtgggat gaggtgcaat cgggtctgcg ggcagccgac gcccccccac    360
ccaccatgcg cgtggctgtc actgccgcgc ggcccccgcg cgccaagccg gcgccgcgac    420
gacgtgctgc gcaaccctcc gacgcttcgc cggcggcgca ggtggatcta cgcacgctcg    480
gctacagcca gcagcaacag gagaagatca aaccgaaggt tcgttcgaca gtggcgcagc    540
accacgaggc actggtcggc cacgggttta cacacgcgca catcgttgcg ttaagccaac    600
acccggcagc gttagggacc gtcgctgtca agtatcagga catgatcgca gcgttgccag    660
aggcgacaca cgaagcgatc gttggcgtcg gcaaacagtg gtccggcgca cgcgctctgg    720
aggccttgct cacggtggcg ggagagttga gaggtccacc gttacagttg gacacaggcc    780
aacttctcaa gattgcaaaa cgtggcggcg tgaccgcagt ggaggcagtg catgcatggc    840
gcaatgcact gacgggtgcc ccgctcaact tgaccggaga cgcccggggg atcaggtcac    900
gtgcgtctcg gagcattgtt gcccagttat ctcgccctga tccggcgttg gccgcgttga    960
ccaacgacca cctcgtcgcc ttggcctgcc tcggcgggcg tcctgcgctg gatgcagtga   1020
aaaagggatt gccgcacgcg ccggccttga tcaaaagaac caatcgccgt attcccgaac   1080
gcacatccca tcgcgttgcc gaccacgcgc aagtggttcg cgtgctgggt tttttccagt   1140
gccactccca cccagcgcaa gcatttgatg acgccatgac gcagttcggg atgagcaggc   1200
acgggttgtt acagctcttt cgcagagtgg gcgtcaccga actcgaagcc cgcagtggaa   1260
cgctcccccc agccagtcag cgttgggacc gtatcctcca ggcatcaggg atgaaaaggg   1320
ccaaaccgtc ccctacttca actcaaacgc cggatcaggc gtctttgcat gcattcgccg   1380
attcgctgga gcgtgacctt gatgcgccta gcccaatgca cgagggagat cagacgcggg   1440
caagtagccg taaacggtcc cgatcggatc gtgctgtcac cggtccctcc gcacagcaat   1500
cgttcgaggt gcgcgttccc gaacagcgcg atgcgctcca tttgcccctc tcctggaggg   1560
taaaacgccc gcgtaccagt atcgggggcg gcctcccgga tcctatcagc cgttcccagc   1620
tggtgaagtc cgagctggag gagaagaaat ccgagttgag gcacaagctg aagtacgtgc   1680
cccacgagta catcgagctg atcgagatcg cccggaacag cacccaggac cgtatcctgg   1740
agatgaaggt gatggagttc ttcatgaagg tgtacggcta caggggcaag cacctgggcg   1800
gctccaggaa gcccgacggc gccatctaca ccgtgggctc ccccatcgac tacggcgtga   1860
tcgtggacac caaggcctac tccggcggct acaacctgcc catcggccag gccgacgaaa   1920
tgcagaggta cgtggaggag aaccagacca ggaacaagca catcaacccc aacgagtggt   1980
ggaaggtgta cccctccagc gtgaccgagt tcaagttcct gttcgtgtcc ggccacttca   2040
agggcaacta caaggcccag ctgaccaggc tgaaccacat caccaactgc aacggcgccg   2100
tgctgtccgt ggaggagctc ctgatcggcg gcgagatgat caaggccggc accctgaccc   2160
tggaggaggt gaggaggaag ttcaacaacg gcgagatcaa cttcgcggcc gactgataa    2219


<210>  7

<211>  287
<212>  PRT
<213>  Complete Nter

<220>

<400>  7
Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro 
1               5                   10                  15      


Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val Ser 
            20                  25                  30          


Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr Met 
        35                  40                  45              


Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser 
    50                  55                  60                  


Ala Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe 
65                  70                  75                  80  


Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His Thr 
                85                  90                  95      


Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg Ala 
            100                 105                 110         


Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala Arg 
        115                 120                 125             


Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser 
    130                 135                 140                 


Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser 
145                 150                 155                 160 


Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala 
                165                 170                 175     


Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile 
            180                 185                 190         


Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys 
        195                 200                 205             


Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile 
    210                 215                 220                 


Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu 
225                 230                 235                 240 


Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr 
                245                 250                 255     


Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu 
            260                 265                 270         


Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285         


<210>  8

<211>  135
<212>  PRT
<213>  Delta152 Nter

<220>

<400>  8
Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys 
1               5                   10                  15      


Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly 
            20                  25                  30          


His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala 
        35                  40                  45              


Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu 
    50                  55                  60                  


Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser 
65                  70                  75                  80  


Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg 
                85                  90                  95      


Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys 
            100                 105                 110         


Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala 
        115                 120                 125             


Leu Thr Gly Ala Pro Leu Asn 
    130                 135 


<210>  9

<211>  598
<212>  PRT
<213>  AVrBs3 RVD

<220>

<400>  9
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    530                 535                 540                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                565                 570                 575     


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
            580                 585                 590         


Gly Arg Pro Ala Leu Glu 
        595             


<210>  10

<211>  19
<212>  DNA
<213>  AvrBs3 target

<220>

<400>  10
tatataaacc taaccctct                                                  19

<210>  11

<211>  1213
<212>  PRT
<213>  pCLS14333

<220>

<400>  11
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Gln Leu Val Lys Ser Glu Leu Glu 
            20                  25                  30          


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
        35                  40                  45              


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
    50                  55                  60                  


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
65                  70                  75                  80  


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
                85                  90                  95      


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
            100                 105                 110         


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
        115                 120                 125             


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
    130                 135                 140                 


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
145                 150                 155                 160 


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
                165                 170                 175     


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
            180                 185                 190         


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
        195                 200                 205             


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ser Ser Gly 
    210                 215                 220                 


Gly Ser Gly Ser Thr Ala Gly Phe Ile Ala Asp Leu Arg Thr Leu Gly 
225                 230                 235                 240 


Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr 
                245                 250                 255     


Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala 
            260                 265                 270         


His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala 
        275                 280                 285             


Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu 
    290                 295                 300                 


Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu 
305                 310                 315                 320 


Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu 
                325                 330                 335     


Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala 
            340                 345                 350         


Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu 
        355                 360                 365             


Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
    370                 375                 380                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
385                 390                 395                 400 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
                405                 410                 415     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            420                 425                 430         


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
        435                 440                 445             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
    450                 455                 460                 


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
465                 470                 475                 480 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                485                 490                 495     


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
            500                 505                 510         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        515                 520                 525             


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
    530                 535                 540                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
545                 550                 555                 560 


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                565                 570                 575     


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            580                 585                 590         


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        595                 600                 605             


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    610                 615                 620                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
625                 630                 635                 640 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
                645                 650                 655     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            660                 665                 670         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        675                 680                 685             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    690                 695                 700                 


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
705                 710                 715                 720 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
                725                 730                 735     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            740                 745                 750         


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
        755                 760                 765             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    770                 775                 780                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
785                 790                 795                 800 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                805                 810                 815     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            820                 825                 830         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        835                 840                 845             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    850                 855                 860                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
865                 870                 875                 880 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                885                 890                 895     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            900                 905                 910         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        915                 920                 925             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    930                 935                 940                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
945                 950                 955                 960 


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
                965                 970                 975     


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
            980                 985                 990         


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
        995                 1000                1005            


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
    1010                1015                1020                


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
1025                1030                1035                1040


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
                1045                1050                1055    


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
            1060                1065                1070        


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
        1075                1080                1085            


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
    1090                1095                1100                


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
1105                1110                1115                1120


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
                1125                1130                1135    


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
            1140                1145                1150        


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
        1155                1160                1165            


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
    1170                1175                1180                


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
1185                1190                1195                1200


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
                1205                1210            


<210>  12

<211>  1365
<212>  PRT
<213>  pCLS12944

<220>

<400>  12
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Gln Leu Val Lys Ser Glu Leu Glu 
            20                  25                  30          


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
        35                  40                  45              


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
    50                  55                  60                  


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
65                  70                  75                  80  


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
                85                  90                  95      


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
            100                 105                 110         


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
        115                 120                 125             


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
    130                 135                 140                 


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
145                 150                 155                 160 


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
                165                 170                 175     


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
            180                 185                 190         


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
        195                 200                 205             


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ser Ser Gly 
    210                 215                 220                 


Gly Ser Gly Ser Thr Ala Gly Phe Ile Ala Asp Pro Ile Arg Ser Arg 
225                 230                 235                 240 


Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly 
                245                 250                 255     


Val Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro 
            260                 265                 270         


Leu Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro 
        275                 280                 285             


Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp 
    290                 295                 300                 


Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp 
305                 310                 315                 320 


Ser Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu 
                325                 330                 335     


Trp Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro 
            340                 345                 350         


Thr Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro 
        355                 360                 365             


Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala 
    370                 375                 380                 


Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
385                 390                 395                 400 


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
                405                 410                 415     


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
            420                 425                 430         


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
        435                 440                 445             


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
    450                 455                 460                 


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
465                 470                 475                 480 


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
                485                 490                 495     


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
            500                 505                 510         


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val 
        515                 520                 525             


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
    530                 535                 540                 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
545                 550                 555                 560 


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
                565                 570                 575     


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
            580                 585                 590         


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
        595                 600                 605             


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
    610                 615                 620                 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
625                 630                 635                 640 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
                645                 650                 655     


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
            660                 665                 670         


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
        675                 680                 685             


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
    690                 695                 700                 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
705                 710                 715                 720 


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
                725                 730                 735     


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
            740                 745                 750         


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
        755                 760                 765             


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
    770                 775                 780                 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
785                 790                 795                 800 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                805                 810                 815     


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
            820                 825                 830         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
        835                 840                 845             


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
    850                 855                 860                 


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
865                 870                 875                 880 


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
                885                 890                 895     


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
            900                 905                 910         


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
        915                 920                 925             


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
    930                 935                 940                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
945                 950                 955                 960 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
                965                 970                 975     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            980                 985                 990         


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
        995                 1000                1005            


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    1010                1015                1020                


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
1025                1030                1035                1040


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                1045                1050                1055    


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
            1060                1065                1070        


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        1075                1080                1085            


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    1090                1095                1100                


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser 
1105                1110                1115                1120


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr 
                1125                1130                1135    


Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu 
            1140                1145                1150        


Asp Ala Val Lys Lys Gly Leu Gly Asp Pro Ile Ser Arg Ser Gln Leu 
        1155                1160                1165            


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
    1170                1175                1180                


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
1185                1190                1195                1200


Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
                1205                1210                1215    


Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro 
            1220                1225                1230        


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
        1235                1240                1245            


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
    1250                1255                1260                


Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys 
1265                1270                1275                1280


His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
                1285                1290                1295    


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
            1300                1305                1310        


Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val 
        1315                1320                1325            


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
    1330                1335                1340                


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
1345                1350                1355                1360


Asn Phe Ala Ala Asp 
                1365


<210>  13

<211>  530
<212>  PRT
<213>  "CAG" RVD array

<220>

<400>  13
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
            340                 345                 350         


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  14

<211>  16
<212>  DNA
<213>  "CAG" target

<220>

<400>  14
gctgctgctg ctgctg                                                     16



<210>  15

<211>  1145
<212>  PRT
<213>  pCLS14332

<220>

<400>  15
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Gln Leu Val Lys Ser Glu Leu Glu 
            20                  25                  30          


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
        35                  40                  45              


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
    50                  55                  60                  


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
65                  70                  75                  80  


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
                85                  90                  95      


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
            100                 105                 110         


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
        115                 120                 125             


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
    130                 135                 140                 


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
145                 150                 155                 160 


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
                165                 170                 175     


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
            180                 185                 190         


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
        195                 200                 205             


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ser Ser Gly 
    210                 215                 220                 


Gly Ser Gly Ser Thr Ala Gly Phe Ile Ala Asp Leu Arg Thr Leu Gly 
225                 230                 235                 240 


Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr 
                245                 250                 255     


Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala 
            260                 265                 270         


His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala 
        275                 280                 285             


Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu 
    290                 295                 300                 


Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu 
305                 310                 315                 320 


Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu 
                325                 330                 335     


Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala 
            340                 345                 350         


Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu 
        355                 360                 365             


Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
    370                 375                 380                 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
385                 390                 395                 400 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp 
                405                 410                 415     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            420                 425                 430         


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
        435                 440                 445             


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    450                 455                 460                 


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
465                 470                 475                 480 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                485                 490                 495     


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
            500                 505                 510         


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        515                 520                 525             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    530                 535                 540                 


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
545                 550                 555                 560 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                565                 570                 575     


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
            580                 585                 590         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        595                 600                 605             


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
    610                 615                 620                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
625                 630                 635                 640 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
                645                 650                 655     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            660                 665                 670         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
        675                 680                 685             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    690                 695                 700                 


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
705                 710                 715                 720 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                725                 730                 735     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            740                 745                 750         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        755                 760                 765             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    770                 775                 780                 


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
785                 790                 795                 800 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                805                 810                 815     


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
            820                 825                 830         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        835                 840                 845             


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    850                 855                 860                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
865                 870                 875                 880 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro 
                885                 890                 895     


Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu 
            900                 905                 910         


Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly 
        915                 920                 925             


Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly Asp Pro Ile Ser 
    930                 935                 940                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
945                 950                 955                 960 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                965                 970                 975     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            980                 985                 990         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        995                 1000                1005            


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    1010                1015                1020                


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
1025                1030                1035                1040


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                1045                1050                1055    


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            1060                1065                1070        


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        1075                1080                1085            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1090                1095                1100                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1105                1110                1115                1120


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1125                1130                1135    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1140                1145


<210>  16

<211>  43
<212>  DNA
<213>  Tail/ Tail 05 bps

<220>
<223>  AvrX05

<400>  16
tatataaacc taaccctcta ggtaagaggg ttaggtttat ata                       43


<210>  17

<211>  44
<212>  DNA
<213>  Tail/ Tail 06 bps

<220>
<223>  AvrX06

<400>  17
tatataaacc taaccctcta aggtaagagg gttaggttta tata                      44


<210>  18

<211>  45
<212>  DNA
<213>  Tail/ Tail 07 bps

<220>
<223>  AvrX07

<400>  18
tatataaacc taaccctcta aggtacagag ggttaggttt atata                     45


<210>  19

<211>  46
<212>  DNA
<213>  Tail/ Tail 08 bps

<220>
<223>  AvrX08

<400>  19
tatataaacc taaccctctg aaggtacaga gggttaggtt tatata                    46


<210>  20

<211>  47
<212>  DNA
<213>  Tail/ Tail 09 bps

<220>
<223>  AvrX09

<400>  20
tatataaacc taaccctctg aaggtaccag agggttaggt ttatata                   47


<210>  21

<211>  48
<212>  DNA
<213>  Tail/ Tail 10 bps

<220>
<223>  AvrX10

<400>  21
tatataaacc taaccctctt gaaggtacca gagggttagg tttatata                  48


<210>  22

<211>  49
<212>  DNA
<213>  Tail/ Tail 11 bps

<220>
<223>  AvrX11

<400>  22
tatataaacc taaccctctt gaaggtacct agagggttag gtttatata                 49


<210>  23

<211>  50
<212>  DNA
<213>  Tail/ Tail 12 bps

<220>
<223>  AvrX12

<400>  23
tatataaacc taaccctcta tgaaggtacc tagagggtta ggtttatata                50


<210>  24

<211>  51
<212>  DNA
<213>  Tail/ Tail 13 bps

<220>
<223>  AvrX13

<400>  24
tatataaacc taaccctcta tgaaggtacc ttagagggtt aggtttatat a              51


<210>  25

<211>  52
<212>  DNA
<213>  Tail/ Tail 14 bps

<220>
<223>  AvrX14

<400>  25
tatataaacc taaccctctc atgaaggtac cttagagggt taggtttata ta             52


<210>  26

<211>  53
<212>  DNA
<213>  Tail/ Tail 15 bps

<220>
<223>  AvrBs3a15AvrBs3a

<400>  26
tatataaacc taaccctctt agcatgaagg taccagaggg ttaggtttat ata            53


<210>  27

<211>  54
<212>  DNA
<213>  Tail/ Tail 16 bps

<220>
<223>  AvrX16

<400>  27
tatataaacc taaccctctg catgaaggta ccttgagagg gttaggttta tata           54


<210>  28

<211>  55
<212>  DNA
<213>  Tail/ Tail 17 bps

<220>
<223>  AvrX17

<400>  28
tatataaacc taaccctctg catgaaggta ccttgtagag ggttaggttt atata          55


<210>  29

<211>  56
<212>  DNA
<213>  Tail/ Tail 18 bps

<220>
<223>  AvrX18

<400>  29
tatataaacc taaccctcta gcatgaaggt accttgtaga gggttaggtt tatata         56


<210>  30

<211>  57
<212>  DNA
<213>  Tail/ Tail 19 bps

<220>
<223>  AvrX19

<400>  30
tatataaacc taaccctcta gcatgaaggt accttgtcag agggttaggt ttatata        57


<210>  31

<211>  58
<212>  DNA
<213>  Tail/ Tail 20 bps

<220>
<223>  AvrX20

<400>  31
tatataaacc taaccctctt agcatgaagg taccttgtca gagggttagg tttatata       58


<210>  32

<211>  59
<212>  DNA
<213>  Tail/ Tail 21 bps

<220>
<223>  AvrBs3a21AvrBs3a

<400>  32
tatataaacc taaccctctt agcatgaagg taccttgtcg agagggttag gtttatata      59


<210>  33

<211>  60
<212>  DNA
<213>  Tail/ Tail 22 bps

<220>
<223>  AvrX22

<400>  33
tatataaacc taaccctctt agcatgaagg taccttgtcg tagagggtta ggtttatata     60


<210>  34

<211>  61
<212>  DNA
<213>  Tail/ Tail 23 bps

<220>
<223>  AvrX23

<400>  34
tatataaacc taaccctctc tagcatgaag gtaccttgtc gtagagggtt aggtttatat     60
a                                                                     61


<210>  35

<211>  62
<212>  DNA
<213>  Tail/ Tail 24 bps

<220>
<223>  AvrX24

<400>  35
tatataaacc taaccctctc tagcatgaag gtaccttgtc gttagagggt taggtttata     60
ta                                                                    62


<210>  36

<211>  63
<212>  DNA
<213>  Tail/ Tail 25 bps

<220>
<223>  AvrX25

<400>  36
tatataaacc taaccctcta ctagcatgaa ggtaccttgt cgttagaggg ttaggtttat     60
ata                                                                   63


<210>  37

<211>  64
<212>  DNA
<213>  Tail/ Tail 26 bps

<220>
<223>  AvrX26

<400>  37
tatataaacc taaccctcta ctagcatgaa ggtaccttgt cgttgagagg gttaggttta     60
tata                                                                  64


<210>  38

<211>  65
<212>  DNA
<213>  Tail/ Tail 27 bps

<220>
<223>  AvrX27

<400>  38
tatataaacc taaccctctc actagcatga aggtaccttg tcgttgagag ggttaggttt     60
atata                                                                 65


<210>  39

<211>  66
<212>  DNA
<213>  Tail/ Tail 28 bps

<220>
<223>  AvrX28

<400>  39
tatataaacc taaccctctc actagcatga aggtaccttg tcgttgaaga gggttaggtt     60
tatata                                                                66


<210>  40

<211>  67
<212>  DNA
<213>  Tail/ Tail 29 bps

<220>
<223>  AvrX 29

<400>  40
tatataaacc taaccctctc cactagcatg aaggtacctt gtcgttgaag agggttaggt     60
ttatata                                                               67


<210>  41

<211>  68
<212>  DNA
<213>  Tail/ Tail 30 bps

<220>
<223>  AvrX30

<400>  41
tatataaacc taaccctctc cactagcatg aaggtacctt gtcgttgata gagggttagg     60
tttatata                                                              68


<210>  42

<211>  69
<212>  DNA
<213>  Tail/ Tail 31 bps

<220>
<223>  AvrX31

<400>  42
tatataaacc taaccctcta ccactagcat gaaggtacct tgtcgttgat agagggttag     60
gtttatata                                                             69


<210>  43

<211>  70
<212>  DNA
<213>  Tail/ Tail 32 bps

<220>
<223>  AvrX32

<400>  43
tatataaacc taaccctcta ccactagcat gaaggtacct tgtcgttgat tagagggtta     60
ggtttatata                                                            70


<210>  44

<211>  71
<212>  DNA
<213>  Tail/ Tail 33 bps

<220>
<223>  AvrX33

<400>  44
tatataaacc taaccctctg accactagca tgaaggtacc ttgtcgttga ttagagggtt     60
aggtttatat a                                                          71


<210>  45

<211>  72
<212>  DNA
<213>  Tail/ Tail 34 bps

<220>
<223>  AvrX34

<400>  45
tatataaacc taaccctctg accactagca tgaaggtacc ttgtcgttga ttcagagggt     60
taggtttata ta                                                         72


<210>  46

<211>  73
<212>  DNA
<213>  Tail/ Tail 35 bps

<220>
<223>  AvrX35

<400>  46
tatataaacc taaccctctt gaccactagc atgaaggtac cttgtcgttg attcagaggg     60
ttaggtttat ata                                                        73


<210>  47

<211>  74
<212>  DNA
<213>  Tail/ Tail 36 bps

<220>
<223>  AvrX36

<400>  47
tatataaacc taaccctctt gaccactagc atgaaggtac cttgtcgttg attcaagagg     60
gttaggttta tata                                                       74


<210>  48

<211>  75
<212>  DNA
<213>  Tail/ Tail 37 bps

<220>
<223>  AvrX37

<400>  48
tatataaacc taaccctctc tgaccactag catgaaggta ccttgtcgtt gattcaagag     60
ggttaggttt atata                                                      75


<210>  49

<211>  76
<212>  DNA
<213>  Tail/ Tail 38 bps

<220>
<223>  AvrX38

<400>  49
tatataaacc taaccctctc tgaccactag catgaaggta ccttgtcgtt gattcagaga     60
gggttaggtt tatata                                                     76


<210>  50

<211>  77
<212>  DNA
<213>  Tail/ Tail 39 bps

<220>
<223>  AvrX39

<400>  50
tatataaacc taaccctctt ctgaccacta gcatgaaggt accttgtcgt tgattcagag     60
agggttaggt ttatata                                                    77


<210>  51

<211>  78
<212>  DNA
<213>  Tail/ Tail 40 bps

<220>
<223>  AvrX40

<400>  51
tatataaacc taaccctctt ctgaccacta gcatgaaggt accttgtcgt tgattcagta     60
gagggttagg tttatata                                                   78


<210>  52

<211>  43
<212>  DNA
<213>  Head/Head 05 bps

<220>
<223>  NfusAvr05b

<400>  52
agagggttag gtttatataa ggtatatata aacctaaccc tct                       43


<210>  53

<211>  44
<212>  DNA
<213>  Head/Head 06 bps

<220>
<223>  NfusAvr06b

<400>  53
agagggttag gtttatataa aggtatatat aaacctaacc ctct                      44


<210>  54

<211>  45
<212>  DNA
<213>  Head/Head 07 bps

<220>
<223>  NfusAvr07b

<400>  54
agagggttag gtttatataa aggtactata taaacctaac cctct                     45


<210>  55

<211>  46
<212>  DNA
<213>  Head/Head 08 bps

<220>
<223>  NfusAvr08b

<400>  55
agagggttag gtttatatag aaggtactat ataaacctaa ccctct                    46


<210>  56

<211>  47
<212>  DNA
<213>  Head/Head 09 bps

<220>
<223>  NfusAvr09b

<400>  56
agagggttag gtttatatag aaggtaccta tataaaccta accctct                   47


<210>  57

<211>  48
<212>  DNA
<213>  Head/Head 10 bps

<220>
<223>  NfusAvr10b

<400>  57
agagggttag gtttatatat gaaggtacct atataaacct aaccctct                  48


<210>  58

<211>  49
<212>  DNA
<213>  Head/Head 11 bps

<220>
<223>  NfusAvr11b

<400>  58
agagggttag gtttatatat gaaggtacct tatataaacc taaccctct                 49


<210>  59

<211>  50
<212>  DNA
<213>  Head/Head 12 bps

<220>
<223>  NfusAvr12b

<400>  59
agagggttag gtttatataa tgaaggtacc ttatataaac ctaaccctct                50


<210>  60

<211>  51
<212>  DNA
<213>  Head/Head 13 bps

<220>
<223>  NfusAvr13b

<400>  60
agagggttag gtttatataa tgaaggtacc tttatataaa cctaaccctc t              51


<210>  61

<211>  52
<212>  DNA
<213>  Head/Head 14 bps

<220>
<223>  NfusAvr14b

<400>  61
agagggttag gtttatatac atgaaggtac ctttatataa acctaaccct ct             52


<210>  62

<211>  53
<212>  DNA
<213>  Head/Head 15 bps

<220>
<223>  NfusAvr15b

<400>  62
agagggttag gtttatatac atgaaggtac cttgtatata aacctaaccc tct            53


<210>  63

<211>  54
<212>  DNA
<213>  Head/Head 16 bps

<220>
<223>  NfusAvr16b

<400>  63
agagggttag gtttatatag catgaaggta ccttgtatat aaacctaacc ctct           54


<210>  64

<211>  55
<212>  DNA
<213>  Head/Head 17 bps

<220>
<223>  NfusAvr17b

<400>  64
agagggttag gtttatatag catgaaggta ccttgttata taaacctaac cctct          55


<210>  65

<211>  56
<212>  DNA
<213>  Head/Head 18 bps

<220>
<223>  NfusAvr18b

<400>  65
agagggttag gtttatataa gcatgaaggt accttgttat ataaacctaa ccctct         56


<210>  66

<211>  57
<212>  DNA
<213>  Head/Head 19 bps

<220>
<223>  NfusAvr19b

<400>  66
agagggttag gtttatataa gcatgaaggt accttgtcta tataaaccta accctct        57


<210>  67

<211>  58
<212>  DNA
<213>  Head/Head 20 bps

<220>
<223>  NfusAvr20b

<400>  67
agagggttag gtttatatat agcatgaagg taccttgtct atataaacct aaccctct       58


<210>  68

<211>  59
<212>  DNA
<213>  Head/Head 21 bps

<220>
<223>  NfusAvr21b

<400>  68
agagggttag gtttatatat agcatgaagg taccttgtcg tatataaacc taaccctct      59


<210>  69

<211>  60
<212>  DNA
<213>  Head/Head 22 bps

<220>
<223>  NfusAvr22b

<400>  69
agagggttag gtttatatat agcatgaagg taccttgtcg ttatataaac ctaaccctct     60


<210>  70

<211>  61
<212>  DNA
<213>  Head/Head 23 bps

<220>
<223>  NfusAvr23b

<400>  70
agagggttag gtttatatac tagcatgaag gtaccttgtc gttatataaa cctaaccctc     60
t                                                                     61


<210>  71

<211>  62
<212>  DNA
<213>  Head/Head 24 bps

<220>
<223>  NfusAvr24b

<400>  71
agagggttag gtttatatac tagcatgaag gtaccttgtc gtttatataa acctaaccct     60
ct                                                                    62


<210>  72

<211>  63
<212>  DNA
<213>  Head/Head 25 bps

<220>
<223>  NfusAvr25b

<400>  72
agagggttag gtttatataa ctagcatgaa ggtaccttgt cgtttatata aacctaaccc     60
tct                                                                   63


<210>  73

<211>  64
<212>  DNA
<213>  Head/Head 26 bps

<220>
<223>  NfusAvr26b

<400>  73
agagggttag gtttatataa ctagcatgaa ggtaccttgt cgttgtatat aaacctaacc     60
ctct                                                                  64


<210>  74

<211>  65
<212>  DNA
<213>  Head/Head 27 bps

<220>
<223>  NfusAvr27b

<400>  74
agagggttag gtttatatac actagcatga aggtaccttg tcgttgtata taaacctaac     60
cctct                                                                 65


<210>  75

<211>  66
<212>  DNA
<213>  Head/Head 28 bps

<220>
<223>  NfusAvr28b

<400>  75
agagggttag gtttatatac actagcatga aggtaccttg tcgttgatat ataaacctaa     60
ccctct                                                                66


<210>  76

<211>  67
<212>  DNA
<213>  Head/Head 29 bps

<220>
<223>  NfusAvr29b

<400>  76
agagggttag gtttatatac cactagcatg aaggtacctt gtcgttgata tataaaccta     60
accctct                                                               67


<210>  77

<211>  68
<212>  DNA
<213>  Head/Head 30 bps

<220>
<223>  NfusAvr30b

<400>  77
agagggttag gtttatatac cactagcatg aaggtacctt gtcgttgatt atataaacct     60
aaccctct                                                              68


<210>  78

<211>  69
<212>  DNA
<213>  Head/Head 31 bps

<220>
<223>  NfusAvr31b

<400>  78
agagggttag gtttatataa ccactagcat gaaggtacct tgtcgttgat tatataaacc     60
taaccctct                                                             69


<210>  79

<211>  70
<212>  DNA
<213>  Head/Head 32 bps

<220>
<223>  NfusAvr32b

<400>  79
agagggttag gtttatataa ccactagcat gaaggtacct tgtcgttgat ttatataaac     60
ctaaccctct                                                            70


<210>  80

<211>  71
<212>  DNA
<213>  Head/Head 33 bps

<220>
<223>  NfusAvr33b

<400>  80
agagggttag gtttatatag accactagca tgaaggtacc ttgtcgttga tttatataaa     60
cctaaccctc t                                                          71


<210>  81

<211>  72
<212>  DNA
<213>  Head/Head 34 bps

<220>
<223>  NfusAvr34b

<400>  81
agagggttag gtttatatag accactagca tgaaggtacc ttgtcgttga ttctatataa     60
acctaaccct ct                                                         72


<210>  82

<211>  73
<212>  DNA
<213>  Head/Head 35 bps

<220>
<223>  NfusAvr35b

<400>  82
agagggttag gtttatatat gaccactagc atgaaggtac cttgtcgttg attctatata     60
aacctaaccc tct                                                        73


<210>  83

<211>  46
<212>  DNA
<213>  TiCAG_sp12

<220>

<400>  83
cagcagcagc agcagcaatg aaggtacctc agcagcagca gcagca                    46


<210>  84

<211>  49
<212>  DNA
<213>  TiCAG_sp15

<220>

<400>  84
cagcagcagc agcagcatag catgaaggta cccagcagca gcagcagca                 49


<210>  85

<211>  52
<212>  DNA
<213>  TiCAG_sp18

<220>

<400>  85
cagcagcagc agcagcaagc atgaaggtac cttgtcagca gcagcagcag ca             52


<210>  86

<211>  55
<212>  DNA
<213>  TiCAG_sp21

<220>

<400>  86
cagcagcagc agcagcatag catgaaggta ccttgtcgca gcagcagcag cagca          55


<210>  87

<211>  58
<212>  DNA
<213>  TiCAG_sp24

<220>

<400>  87
cagcagcagc agcagcacta gcatgaaggt accttgtcgt tcagcagcag cagcagca       58


<210>  88

<211>  61
<212>  DNA
<213>  TiCAG_sp27

<220>

<400>  88
cagcagcagc agcagcacac tagcatgaag gtaccttgtc gttgcagcag cagcagcagc     60
a                                                                     61


<210>  89

<211>  64
<212>  DNA
<213>  TiCAG_sp30

<220>

<400>  89
cagcagcagc agcagcacca ctagcatgaa ggtaccttgt cgttgatcag cagcagcagc     60
agca                                                                  64


<210>  90

<211>  59
<212>  DNA
<213>  TiCAG

<220>

<400>  90
cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagca      59


<210>  81

<211>  375
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FokI

<400>  91
Met Ala Ser Gly Pro Asn Arg Gly Val Thr Lys Gln Leu Val Lys Ser 
1               5                   10                  15      


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
            20                  25                  30          


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
        35                  40                  45              


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
    50                  55                  60                  


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
65                  70                  75                  80  


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
                85                  90                  95      


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
            100                 105                 110         


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
        115                 120                 125             


Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys 
    130                 135                 140                 


Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu 
145                 150                 155                 160 


Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val 
                165                 170                 175     


Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr 
            180                 185                 190         


Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Gly 
        195                 200                 205             


Ser Ser Gly Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln 
    210                 215                 220                 


Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu 
225                 230                 235                 240 


Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser 
                245                 250                 255     


Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met 
            260                 265                 270         


Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly 
        275                 280                 285             


Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala 
    290                 295                 300                 


Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu 
305                 310                 315                 320 


Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala 
                325                 330                 335     


Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Gly Asp Ala 
            340                 345                 350         


Arg Gly Ile Arg Ser Arg Ala Ser Arg Ser Ile Val Ala Gln Leu Ser 
        355                 360                 365             


Arg Pro Asp Pro Ser Ala Asp 
    370                 375 



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