                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
       Salas, Joe
       Kistanova, Elena
       Hong, Vu Phong
       Mezo, Adam R.
       Peters, Robert
 
<120>  Chimeric Clotting Factors

<130>  2159.392PC04/EKS/C-K/E-H

<140>  To be assigned
<141>  Herewith

<150>  61/829,775
<151>  2013-05-31

<150>  61/801,603
<151>  2013-03-15

<150>  61/759,817
<151>  2013-02-01

<150>  61/657,685
<151>  2012-06-08

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  1

Ala Leu Arg Pro Arg 
1               5   


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular processing site

<400>  2

Arg Arg Arg Arg 
1               


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular processing site

<400>  3

Arg Lys Arg Arg Lys Arg 
1               5       


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  may be repeated 1-400 times

<400>  4

Gly Gly Gly Gly Ser 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker


<220>
<221>  REPEAT
<222>  (2)..(6)
<223>  n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 46, 
       50, 55, 60, 70, 80, 90, or 100

<400>  5

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  6

Thr Gln Ser Phe Asn Asp Phe Thr Arg 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  7

Ser Val Ser Gln Thr Ser Lys Leu Thr Arg 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  8

Asp Phe Leu Ala Glu Gly Gly Gly Val Arg 
1               5                   10  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  9

Thr Thr Lys Ile Lys Pro Arg 
1               5           


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  10

Leu Val Pro Arg Gly 
1               5   


<210>  11
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  12
<211>  1467
<212>  DNA
<213>  Homo sapiens

<400>  12
atggggcgcc cactgcacct cgtcctgctc agtgcctccc tggctggcct cctgctgctc       60

ggggaaagtc tgttcatccg cagggagcag gccaacaaca tcctggcgag ggtcacgagg      120

gccaattcct ttcttgaaga gatgaagaaa ggacacctcg aaagagagtg catggaagag      180

acctgctcat acgaagaggc ccgcgaggtc tttgaggaca gcgacaagac gaatgaattc      240

tggaataaat acaaagatgg cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa      300

tgtaaagacg gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac      360

tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc      420

cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct ggctgacaac      480

ggcaaggcct gcattcccac agggccctac ccctgtggga aacagaccct ggaacgcagg      540

aagaggtcag tggcccaggc caccagcagc agcggggagg cccctgacag catcacatgg      600

aagccatatg atgcagccga cctggacccc accgagaacc ccttcgacct gcttgacttc      660

aaccagacgc agcctgagag gggcgacaac aacctcacca ggatcgtggg aggccaggaa      720

tgcaaggacg gggagtgtcc ctggcaggcc ctgctcatca atgaggaaaa cgagggtttc      780

tgtggtggaa ccattctgag cgagttctac atcctaacgg cagcccactg tctctaccaa      840

gccaagagat tcaaggtgag ggtaggggac cggaacacgg agcaggagga gggcggtgag      900

gcggtgcacg aggtggaggt ggtcatcaag cacaaccggt tcacaaagga gacctatgac      960

ttcgacatcg ccgtgctccg gctcaagacc cccatcacct tccgcatgaa cgtggcgcct     1020

gcctgcctcc ccgagcgtga ctgggccgag tccacgctga tgacgcagaa gacggggatt     1080

gtgagcggct tcgggcgcac ccacgagaag ggccggcagt ccaccaggct caagatgctg     1140

gaggtgccct acgtggaccg caacagctgc aagctgtcca gcagcttcat catcacccag     1200

aacatgttct gtgccggcta cgacaccaag caggaggatg cctgccaggg ggacagcggg     1260

ggcccgcacg tcacccgctt caaggacacc tacttcgtga caggcatcgt cagctgggga     1320

gagggctgtg cccgtaaggg gaagtacggg atctacacca aggtcaccgc cttcctcaag     1380

tggatcgaca ggtccatgaa aaccaggggc ttgcccaagg ccaagagcca tgccccggag     1440

gtcataacgt cctctccatt aaagtga                                         1467


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  13

Lys Leu Thr Arg 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  14

Asp Phe Thr Arg 
1               


<210>  15
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
        195                 200                 205             


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
    210                 215                 220                 


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
225                 230                 235                 240 


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                245                 250                 255     


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
            260                 265                 270         


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
        275                 280                 285             


Asn Ser Pro Leu Asn Val Ser 
    290                 295 


<210>  16
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  16
atggagaccc ctgcctggcc ccgggtcccg cgccccgaga ccgccgtcgc tcggacgctc       60

ctgctcggct gggtcttcgc ccaggtggcc ggcgcttcag gcactacaaa tactgtggca      120

gcatataatt taacttggaa atcaactaat ttcaagacaa ttttggagtg ggaacccaaa      180

cccgtcaatc aagtctacac tgttcaaata agcactaagt caggagattg gaaaagcaaa      240

tgcttttaca caacagacac agagtgtgac ctcaccgacg agattgtgaa ggatgtgaag      300

cagacgtact tggcacgggt cttctcctac ccggcaggga atgtggagag caccggttct      360

gctggggagc ctctgtatga gaactcccca gagttcacac cttacctgga gacaaacctc      420

ggacagccaa caattcagag ttttgaacag gtgggaacaa aagtgaatgt gaccgtagaa      480

gatgaacgga ctttagtcag aaggaacaac actttcctaa gcctccggga tgtttttggc      540

aaggacttaa tttatacact ttattattgg aaatcttcaa gttcaggaaa gaaaacagcc      600

aaaacaaaca ctaatgagtt tttgattgat gtggataaag gagaaaacta ctgtttcagt      660

gttcaagcag tgattccctc ccgaacagtt aaccggaaga gtacagacag cccggtagag      720

tgtatgggcc aggagaaagg ggaattcaga gaaatattct acatcattgg agctgtggta      780

tttgtggtca tcatccttgt catcatcctg gctatatctc tacacaagtg tagaaaggca      840

ggagtggggc agagctggaa ggagaactcc ccactgaatg tttcataa                   888


<210>  17
<211>  2224
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210>  18
<211>  6675
<212>  DNA
<213>  Homo sapiens

<400>  18
atgttcccag gctgcccacg cctctgggtc ctggtggtct tgggcaccag ctgggtaggc       60

tgggggagcc aagggacaga agcggcacag ctaaggcagt tctacgtggc tgctcagggc      120

atcagttgga gctaccgacc tgagcccaca aactcaagtt tgaatctttc tgtaacttcc      180

tttaagaaaa ttgtctacag agagtatgaa ccatatttta agaaagaaaa accacaatct      240

accatttcag gacttcttgg gcctacttta tatgctgaag tcggagacat cataaaagtt      300

cactttaaaa ataaggcaga taagcccttg agcatccatc ctcaaggaat taggtacagt      360

aaattatcag aaggtgcttc ttaccttgac cacacattcc ctgcggagaa gatggacgac      420

gctgtggctc caggccgaga atacacctat gaatggagta tcagtgagga cagtggaccc      480

acccatgatg accctccatg cctcacacac atctattact cccatgaaaa tctgatcgag      540

gatttcaact cggggctgat tgggcccctg cttatctgta aaaaagggac cctaactgag      600

ggtgggacac agaagacgtt tgacaagcaa atcgtgctac tatttgctgt gtttgatgaa      660

agcaagagct ggagccagtc atcatcccta atgtacacag tcaatggata tgtgaatggg      720

acaatgccag atataacagt ttgtgcccat gaccacatca gctggcatct gctgggaatg      780

agctcggggc cagaattatt ctccattcat ttcaacggcc aggtcctgga gcagaaccat      840

cataaggtct cagccatcac ccttgtcagt gctacatcca ctaccgcaaa tatgactgtg      900

ggcccagagg gaaagtggat catatcttct ctcaccccaa aacatttgca agctgggatg      960

caggcttaca ttgacattaa aaactgccca aagaaaacca ggaatcttaa gaaaataact     1020

cgtgagcaga ggcggcacat gaagaggtgg gaatacttca ttgctgcaga ggaagtcatt     1080

tgggactatg cacctgtaat accagcgaat atggacaaaa aatacaggtc tcagcatttg     1140

gataatttct caaaccaaat tggaaaacat tataagaaag ttatgtacac acagtacgaa     1200

gatgagtcct tcaccaaaca tacagtgaat cccaatatga aagaagatgg gattttgggt     1260

cctattatca gagcccaggt cagagacaca ctcaaaatcg tgttcaaaaa tatggccagc     1320

cgcccctata gcatttaccc tcatggagtg accttctcgc cttatgaaga tgaagtcaac     1380

tcttctttca cctcaggcag gaacaacacc atgatcagag cagttcaacc aggggaaacc     1440

tatacttata agtggaacat cttagagttt gatgaaccca cagaaaatga tgcccagtgc     1500

ttaacaagac catactacag tgacgtggac atcatgagag acatcgcctc tgggctaata     1560

ggactacttc taatctgtaa gagcagatcc ctggacaggc gaggaataca gagggcagca     1620

gacatcgaac agcaggctgt gtttgctgtg tttgatgaga acaaaagctg gtaccttgag     1680

gacaacatca acaagttttg tgaaaatcct gatgaggtga aacgtgatga ccccaagttt     1740

tatgaatcaa acatcatgag cactatcaat ggctatgtgc ctgagagcat aactactctt     1800

ggattctgct ttgatgacac tgtccagtgg cacttctgta gtgtggggac ccagaatgaa     1860

attttgacca tccacttcac tgggcactca ttcatctatg gaaagaggca tgaggacacc     1920

ttgaccctct tccccatgcg tggagaatct gtgacggtca caatggataa tgttggaact     1980

tggatgttaa cttccatgaa ttctagtcca agaagcaaaa agctgaggct gaaattcagg     2040

gatgttaaat gtatcccaga tgatgatgaa gactcatatg agatttttga acctccagaa     2100

tctacagtca tggctacacg gaaaatgcat gatcgtttag aacctgaaga tgaagagagt     2160

gatgctgact atgattacca gaacagactg gctgcagcat taggaatcag gtcattccga     2220

aactcatcat tgaatcagga agaagaagag ttcaatctta ctgccctagc tctggagaat     2280

ggcactgaat tcgtttcttc aaacacagat ataattgttg gttcaaatta ttcttcccca     2340

agtaatatta gtaagttcac tgtcaataac cttgcagaac ctcagaaagc cccttctcac     2400

caacaagcca ccacagctgg ttccccactg agacacctca ttggcaagaa ctcagttctc     2460

aattcttcca cagcagagca ttccagccca tattctgaag accctataga ggatcctcta     2520

cagccagatg tcacagggat acgtctactt tcacttggtg ctggagaatt caaaagtcaa     2580

gaacatgcta agcataaggg acccaaggta gaaagagatc aagcagcaaa gcacaggttc     2640

tcctggatga aattactagc acataaagtt gggagacacc taagccaaga cactggttct     2700

ccttccggaa tgaggccctg ggaggacctt cctagccaag acactggttc tccttccaga     2760

atgaggccct ggaaggaccc tcctagtgat ctgttactct taaaacaaag taactcatct     2820

aagattttgg ttgggagatg gcatttggct tctgagaaag gtagctatga aataatccaa     2880

gatactgatg aagacacagc tgttaacaat tggctgatca gcccccagaa tgcctcacgt     2940

gcttggggag aaagcacccc tcttgccaac aagcctggaa agcagagtgg ccacccaaag     3000

tttcctagag ttagacataa atctctacaa gtaagacagg atggaggaaa gagtagactg     3060

aagaaaagcc agtttctcat taagacacga aaaaagaaaa aagagaagca cacacaccat     3120

gctcctttat ctccgaggac ctttcaccct ctaagaagtg aagcctacaa cacattttca     3180

gaaagaagac ttaagcattc gttggtgctt cataaatcca atgaaacatc tcttcccaca     3240

gacctcaatc agacattgcc ctctatggat tttggctgga tagcctcact tcctgaccat     3300

aatcagaatt cctcaaatga cactggtcag gcaagctgtc ctccaggtct ttatcagaca     3360

gtgcccccag aggaacacta tcaaacattc cccattcaag accctgatca aatgcactct     3420

acttcagacc ccagtcacag atcctcttct ccagagctca gtgaaatgct tgagtatgac     3480

cgaagtcaca agtccttccc cacagatata agtcaaatgt ccccttcctc agaacatgaa     3540

gtctggcaga cagtcatctc tccagacctc agccaggtga ccctctctcc agaactcagc     3600

cagacaaacc tctctccaga cctcagccac acgactctct ctccagaact cattcagaga     3660

aacctttccc cagccctcgg tcagatgccc atttctccag acctcagcca tacaaccctt     3720

tctccagacc tcagccatac aaccctttct ttagacctca gccagacaaa cctctctcca     3780

gaactcagtc agacaaacct ttctccagcc ctcggtcaga tgcccctttc tccagacctc     3840

agccatacaa ccctttctct agacttcagc cagacaaacc tctctccaga actcagccat     3900

atgactctct ctccagaact cagtcagaca aacctttccc cagccctcgg tcagatgccc     3960

atttctccag acctcagcca tacaaccctt tctctagact tcagccagac aaacctctct     4020

ccagaactca gtcaaacaaa cctttcccca gccctcggtc agatgcccct ttctccagac     4080

cccagccata caaccctttc tctagacctc agccagacaa acctctctcc agaactcagt     4140

cagacaaacc tttccccaga cctcagtgag atgcccctct ttgcagatct cagtcaaatt     4200

ccccttaccc cagacctcga ccagatgaca ctttctccag accttggtga gacagatctt     4260

tccccaaact ttggtcagat gtccctttcc ccagacctca gccaggtgac tctctctcca     4320

gacatcagtg acaccaccct tctcccggat ctcagccaga tatcacctcc tccagacctt     4380

gatcagatat tctacccttc tgaatctagt cagtcattgc ttcttcaaga atttaatgag     4440

tcttttcctt atccagacct tggtcagatg ccatctcctt catctcctac tctcaatgat     4500

acttttctat caaaggaatt taatccactg gttatagtgg gcctcagtaa agatggtaca     4560

gattacattg agatcattcc aaaggaagag gtccagagca gtgaagatga ctatgctgaa     4620

attgattatg tgccctatga tgacccctac aaaactgatg ttaggacaaa catcaactcc     4680

tccagagatc ctgacaacat tgcagcatgg tacctccgca gcaacaatgg aaacagaaga     4740

aattattaca ttgctgctga agaaatatcc tgggattatt cagaatttgt acaaagggaa     4800

acagatattg aagactctga tgatattcca gaagatacca catataagaa agtagttttt     4860

cgaaagtacc tcgacagcac ttttaccaaa cgtgatcctc gaggggagta tgaagagcat     4920

ctcggaattc ttggtcctat tatcagagct gaagtggatg atgttatcca agttcgtttt     4980

aaaaatttag catccagacc gtattctcta catgcccatg gactttccta tgaaaaatca     5040

tcagagggaa agacttatga agatgactct cctgaatggt ttaaggaaga taatgctgtt     5100

cagccaaata gcagttatac ctacgtatgg catgccactg agcgatcagg gccagaaagt     5160

cctggctctg cctgtcgggc ttgggcctac tactcagctg tgaacccaga aaaagatatt     5220

cactcaggct tgataggtcc cctcctaatc tgccaaaaag gaatactaca taaggacagc     5280

aacatgccta tggacatgag agaatttgtc ttactattta tgacctttga tgaaaagaag     5340

agctggtact atgaaaagaa gtcccgaagt tcttggagac tcacatcctc agaaatgaaa     5400

aaatcccatg agtttcacgc cattaatggg atgatctaca gcttgcctgg cctgaaaatg     5460

tatgagcaag agtgggtgag gttacacctg ctgaacatag gcggctccca agacattcac     5520

gtggttcact ttcacggcca gaccttgctg gaaaatggca ataaacagca ccagttaggg     5580

gtctggcccc ttctgcctgg ttcatttaaa actcttgaaa tgaaggcatc aaaacctggc     5640

tggtggctcc taaacacaga ggttggagaa aaccagagag cagggatgca aacgccattt     5700

cttatcatgg acagagactg taggatgcca atgggactaa gcactggtat catatctgat     5760

tcacagatca aggcttcaga gtttctgggt tactgggagc ccagattagc aagattaaac     5820

aatggtggat cttataatgc ttggagtgta gaaaaacttg cagcagaatt tgcctctaaa     5880

ccttggatcc aggtggacat gcaaaaggaa gtcataatca cagggatcca gacccaaggt     5940

gccaaacact acctgaagtc ctgctatacc acagagttct atgtagctta cagttccaac     6000

cagatcaact ggcagatctt caaagggaac agcacaagga atgtgatgta ttttaatggc     6060

aattcagatg cctctacaat aaaagagaat cagtttgacc cacctattgt ggctagatat     6120

attaggatct ctccaactcg agcctataac agacctaccc ttcgattgga actgcaaggt     6180

tgtgaggtaa atggatgttc cacacccctg ggtatggaaa atggaaagat agaaaacaag     6240

caaatcacag cttcttcgtt taagaaatct tggtggggag attactggga acccttccgt     6300

gcccgtctga atgcccaggg acgtgtgaat gcctggcaag ccaaggcaaa caacaataag     6360

cagtggctag aaattgatct actcaagatc aagaagataa cggcaattat aacacagggc     6420

tgcaagtctc tgtcctctga aatgtatgta aagagctata ccatccacta cagtgagcag     6480

ggagtggaat ggaaaccata caggctgaaa tcctccatgg tggacaagat ttttgaagga     6540

aatactaata ccaaaggaca tgtgaagaac tttttcaacc ccccaatcat ttccaggttt     6600

atccgtgtca ttcctaaaac atggaatcaa agtattgcac ttcgcctgga actctttggc     6660

tgtgatattt actag                                                      6675


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  19

Lys Leu Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe 
1               5                   10          


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  20

Arg Arg Ala Pro Gly Lys Leu Thr Cys Leu Ala Ser Tyr Cys Trp Leu 
1               5                   10                  15      


Phe Trp Thr Gly Ile Ala 
            20          


<210>  21
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  21

Arg Arg Ala Pro Gly Lys Leu Gln Cys Leu Ala Ser Tyr Cys Trp Leu 
1               5                   10                  15      


Phe Trp Thr Gly Ile Ala 
            20          


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  22

Pro Arg Ile Arg Thr Val Gly Pro Gly Ser Arg Ser Ala Ser Gly Lys 
1               5                   10                  15      


Leu Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe Trp Thr Gly Ile Ala 
            20                  25                  30          


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  23

Ser Lys Gln Gly Arg Pro Ile Ser Pro Asp Arg Arg Ala Ala Gly Lys 
1               5                   10                  15      


Leu Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe Trp Thr Gly Ile Ala 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  24

Pro Arg Ile Arg Thr Val Gly Pro Gly Ser Arg Ser Ala Ser Gly Lys 
1               5                   10                  15      


Ser Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe Trp Thr Gly Ile Ala 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  25

Ser Arg Ile Arg Thr Val Ser Pro Gly Ser Arg Ser Ala Ser Gly Lys 
1               5                   10                  15      


Ser Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe Trp Thr Gly Ile Ala 
            20                  25                  30          


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  procoagulant peptide

<400>  26

Pro Arg Ser Arg Thr Val Gly Pro Gly Ser Arg Ser Ala Ser Gly Lys 
1               5                   10                  15      


Ser Thr Cys Leu Ala Ser Tyr Cys Trp Leu Phe Trp Thr Gly Ile Ala 
            20                  25                  30          


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin constant region

<400>  27

Pro Lys Asn Ser Ser Met Ile Ser Asn Thr Pro 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin constant region

<400>  28

His Gln Ser Leu Gly Thr Gln 
1               5           


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin constant region

<400>  29

His Gln Asn Leu Ser Asp Gly Lys 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin constant region

<400>  30

His Gln Asn Ile Ser Asp Gly Lys 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin constant region

<400>  31

Val Ile Ser Ser His Leu Gly Gln 
1               5               


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  32

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


<210>  33
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP peptide

<400>  33

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  albumin binging protein


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa  is Asp, Asn, Ser, Thr, or Trp

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa  is Asn, Gln, H is, Ile, Leu, or Lys

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Ala, Asp, Phe, Trp, or Tyr

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Asp, Gly, Leu, Phe, Ser, or Thr

<400>  34

Cys Xaa Xaa Xaa Xaa Cys 
1               5       


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  albumin binding peptide

<400>  35

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  36

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  37

Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ser 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  38

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser Ser 
            20  


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  39

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  40

Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ser Pro Ala 
            20  


<210>  41
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  41

Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala Pro Pro Ala 
            20                  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS sequence

<400>  42

Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 
1               5                   10                  15      


Ser Ala Ala Ala 
            20  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gly-ser linker

<400>  43

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  44
<211>  3660
<212>  DNA
<213>  Homo sapiens

<400>  44
aagcttgccg ccaccatggt ctcccaggcc ctcaggctcc tctgccttct gcttgggctt       60

cagggctgcc tggctgcagt cttcgtaacc caggaggaag cccacggcgt cctgcaccgg      120

cgccggcgcg ccaacgcgtt cctggaggag ctgcggccgg gctccctgga gagggagtgc      180

aaggaggagc agtgctcctt cgaggaggcc cgggagatct tcaaggacgc ggagaggacg      240

aagctgttct ggatttctta cagtgatggg gaccagtgtg cctcaagtcc atgccagaat      300

gggggctcct gcaaggacca gctccagtcc tatatctgct tctgcctccc tgccttcgag      360

ggccggaact gtgagacgca caaggatgac cagctgatct gtgtgaacga gaacggcggc      420

tgtgagcagt actgcagtga ccacacgggc accaagcgct cctgtcggtg ccacgagggg      480

tactctctgc tggcagacgg ggtgtcctgc acacccacag ttgaatatcc atgtggaaaa      540

atacctattc tagaaaaaag aaatgccagc aaaccccaag gcgccctgcg gccccggatt      600

gtggggggca aggtgtgccc caaaggggag tgtccatggc aggtcctgtt gttggtgaat      660

ggagctcagt tgtgtggggg gaccctgatc aacaccatct gggtggtctc cgcggcccac      720

tgtttcgaca aaatcaagaa ctggaggaac ctgatcgcgg tgctgggcga gcacgacctc      780

agcgagcacg acggggatga gcagagccgg cgggtggcgc aggtcatcat ccccagcacg      840

tacgtcccgg gcaccaccaa ccacgacatc gcgctgctcc gcctgcacca gcccgtggtc      900

ctcactgacc atgtggtgcc cctctgcctg cccgaacgga cgttctctga gaggacgctg      960

gccttcgtgc gcttctcatt ggtcagcggc tggggccagc tgctggaccg tggcgccacg     1020

gccctggagc tcatggtcct caacgtgccc cggctgatga cccaggactg cctgcagcag     1080

tcacggaagg tgggagactc cccaaatatc acggagtaca tgttctgtgc cggctactcg     1140

gatggcagca aggactcctg caagggggac agtggaggcc cacatgccac ccactaccgg     1200

ggcacgtggt acctgacggg catcgtcagc tggggccagg gctgcgcaac cgtgggccac     1260

tttggggtgt acaccagggt ctcccagtac atcgagtggc tgcaaaagct catgcgctca     1320

gagccacgcc caggagtcct cctgcgagcc ccatttcccg gtggcggtgg ctccggcgga     1380

ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg ttccggtggc     1440

gggggatccg acaaaactca cacatgccca ccgtgcccag ctccggaact cctgggagga     1500

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1560

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1620

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1860

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ttggactccg acggctcctt cttcctctac agcaagctca ccgtcgacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagcc tctccctgtc tccgggtaaa cggcgccgcc ggagcggcgg tggaggttcc     2160

ggtggcggcg gatcaggtgg cggcggatca ggtgggggtg gatcaggtgg cgggggatcc     2220

aggaagagga ggaagaggtc aggcactaca aatactgtgg cagcatataa tttaacttgg     2280

aaatcaacta atttcaagac aattttggag tgggaaccca aacccgtcaa tcaagtctac     2340

actgttcaaa taagcactaa gtcaggagat tggaaaagca aatgctttta cacaacagac     2400

acagagtgtg acctcaccga cgagattgtg aaggatgtga agcagacgta cttggcacgg     2460

gtcttctcct acccggcagg gaatgtggag agcaccggtt ctgctgggga gcctctgtat     2520

gagaactccc cagagttcac accttacctg gagacaaacc tcggacagcc aacaattcag     2580

agttttgaac aggtgggaac aaaagtgaat gtgaccgtag aagatgaacg gactttagtc     2640

agaaggaaca acactttcct aagcctccgg gatgtttttg gcaaggactt aatttataca     2700

ctttattatt ggaaatcttc aagttcagga aagaaaacag ccaaaacaaa cactaatgag     2760

tttttgattg atgtggataa aggagaaaac tactgtttca gtgttcaagc agtgattccc     2820

tcccgaacag ttaaccggaa gagtacagac agcccggtag agtgtatggg ccaggagaaa     2880

ggggaattca gagaaggtgg cggcggatca ggtgggggtg gatcaggcgg tggaggttcc     2940

ggtggcggcg gatcaggtgg cggcggatca ggtgggggtg gatcaggtgg cggcggatca     3000

ggtggcgggg gatcagacaa aactcacaca tgcccaccgt gcccagcacc ggaactcctg     3060

ggcggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     3120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     3180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     3240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     3300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     3360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     3420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     3480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     3540

cccgtgttgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     3600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     3660


<210>  45
<211>  1227
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Ala Leu Arg 
            180                 185                 190         


Pro Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp 
        195                 200                 205             


Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu 
    210                 215                 220                 


Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile 
225                 230                 235                 240 


Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser 
                245                 250                 255     


Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile 
            260                 265                 270         


Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu 
        275                 280                 285             


Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys 
    290                 295                 300                 


Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe 
305                 310                 315                 320 


Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala 
                325                 330                 335     


Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys 
            340                 345                 350         


Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr 
        355                 360                 365             


Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly 
    370                 375                 380                 


Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu 
385                 390                 395                 400 


Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe 
                405                 410                 415     


Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu 
            420                 425                 430         


Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


Lys Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
                725                 730                 735     


Lys Arg Arg Lys Arg Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
            740                 745                 750         


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
        755                 760                 765             


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
    770                 775                 780                 


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
785                 790                 795                 800 


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
                805                 810                 815     


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
            820                 825                 830         


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
        835                 840                 845             


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
    850                 855                 860                 


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
865                 870                 875                 880 


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
                885                 890                 895     


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
            900                 905                 910         


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
        915                 920                 925             


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
    930                 935                 940                 


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
945                 950                 955                 960 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            980                 985                 990         


Gly Gly Ser Gly Gly Gly Gly Ser  Asp Lys Thr His Thr  Cys Pro Pro 
        995                 1000                 1005             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1010                 1015                 1020             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1025                 1030                 1035             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1040                 1045                 1050             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1055                 1060                 1065             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1070                 1075                 1080             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1085                 1090                 1095             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1100                 1105                 1110             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1115                 1120                 1125             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1130                 1135                 1140             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1145                 1150                 1155             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1160                 1165                 1170             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1175                 1180                 1185             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1190                 1195                 1200             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1205                 1210                 1215             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1220                 1225         


<210>  46
<211>  3699
<212>  DNA
<213>  Homo sapiens

<400>  46
aagcttgccg ccaccatggt ctcccaggcc ctcaggctcc tctgccttct gcttgggctt       60

cagggctgcc tggctgcagt cttcgtaacc caggaggaag cccacggcgt cctgcaccgg      120

cgccggcgcg ccaacgcgtt cctggaggag ctgcggccgg gctccctgga gagggagtgc      180

aaggaggagc agtgctcctt cgaggaggcc cgggagatct tcaaggacgc ggagaggacg      240

aagctgttct ggatttctta cagtgatggg gaccagtgtg cctcaagtcc atgccagaat      300

gggggctcct gcaaggacca gctccagtcc tatatctgct tctgcctccc tgccttcgag      360

ggccggaact gtgagacgca caaggatgac cagctgatct gtgtgaacga gaacggcggc      420

tgtgagcagt actgcagtga ccacacgggc accaagcgct cctgtcggtg ccacgagggg      480

tactctctgc tggcagacgg ggtgtcctgc acacccacag ttgaatatcc atgtggaaaa      540

atacctattc tagaaaaaag aaatgccagc aaaccccaag gcgccctgcg gcccgccatt      600

gtggggggca aggtgtgccc caaaggggag tgtccatggc aggtcctgtt gttggtgaat      660

ggagctcagt tgtgtggggg gaccctgatc aacaccatct gggtggtctc cgcggcccac      720

tgtttcgaca aaatcaagaa ctggaggaac ctgatcgcgg tgctgggcga gcacgacctc      780

agcgagcacg acggggatga gcagagccgg cgggtggcgc aggtcatcat ccccagcacg      840

tacgtcccgg gcaccaccaa ccacgacatc gcgctgctcc gcctgcacca gcccgtggtc      900

ctcactgacc atgtggtgcc cctctgcctg cccgaacgga cgttctctga gaggacgctg      960

gccttcgtgc gcttctcatt ggtcagcggc tggggccagc tgctggaccg tggcgccacg     1020

gccctggagc tcatggtcct caacgtgccc cggctgatga cccaggactg cctgcagcag     1080

tcacggaagg tgggagactc cccaaatatc acggagtaca tgttctgtgc cggctactcg     1140

gatggcagca aggactcctg caagggggac agtggaggcc cacatgccac ccactaccgg     1200

ggcacgtggt acctgacggg catcgtcagc tggggccagg gctgcgcaac cgtgggccac     1260

tttggggtgt acaccagggt ctcccagtac atcgagtggc tgcaaaagct catgcgctca     1320

gagccacgcc caggagtcct cctgcgagcc ccatttcccg gtggcggtgg ctccggcgga     1380

ggtgggtccg gtggcggcgg atcaggtggg ggtggatcag gcggtggagg ttccggtggc     1440

gggggatccg acaaaactca cacatgccca ccgtgcccag ctccggaact cctgggagga     1500

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1560

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1620

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1860

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ttggactccg acggctcctt cttcctctac agcaagctca ccgtcgacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagcc tctccctgtc tccgggtaaa cggcgccgcc ggagcggcgg tggaggttcc     2160

ggtggcggcg gatcaggtgg cggcggatca ggtgggggtg gatcaggtgg cgggggatcc     2220

aggaagagga ggaagaggtc aggcactaca aatactgtgg cagcatataa tttaacttgg     2280

aaatcaacta atttcaagac aattttggag tgggaaccca aacccgtcaa tcaagtctac     2340

actgttcaaa taagcactaa gtcaggagat tggaaaagca aatgctttta cacaacagac     2400

acagagtgtg acctcaccga cgagattgtg aaggatgtga agcagacgta cttggcacgg     2460

gtcttctcct acccggcagg gaatgtggag agcaccggtt ctgctgggga gcctctgtat     2520

gagaactccc cagagttcac accttacctg gagacaaacc tcggacagcc aacaattcag     2580

agttttgaac aggtgggaac aaaagtgaat gtgaccgtag aagatgaacg gactttagtc     2640

agaaggaaca acactttcct aagcctccgg gatgtttttg gcaaggactt aatttataca     2700

ctttattatt ggaaatcttc aagttcagga aagaaaacag ccaaaacaaa cactaatgag     2760

tttttgattg atgtggataa aggagaaaac tactgtttca gtgttcaagc agtgattccc     2820

tcccgaacag ttaaccggaa gagtacagac agcccggtag agtgtatggg ccaggagaaa     2880

ggggaattca gagaaggtgg cggcggatca ggtgggggtg gatcaggcgg tggaggttcc     2940

ggtggcggcg gatcaggtgg cggcggatca ggtgggggtg gatcaggtgg cggcggatca     3000

ggtggcgggg gatcagacaa aactcacaca tgcccaccgt gcccagcacc ggaactcctg     3060

ggcggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     3120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     3180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     3240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     3300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     3360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     3420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     3480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     3540

cccgtgttgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     3600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     3660

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            3699


<210>  47
<211>  1227
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Ala Leu Arg 
            180                 185                 190         


Pro Ala Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp 
        195                 200                 205             


Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu 
    210                 215                 220                 


Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile 
225                 230                 235                 240 


Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser 
                245                 250                 255     


Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile 
            260                 265                 270         


Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu 
        275                 280                 285             


Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys 
    290                 295                 300                 


Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe 
305                 310                 315                 320 


Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala 
                325                 330                 335     


Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys 
            340                 345                 350         


Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr 
        355                 360                 365             


Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly 
    370                 375                 380                 


Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu 
385                 390                 395                 400 


Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe 
                405                 410                 415     


Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu 
            420                 425                 430         


Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


Lys Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
                725                 730                 735     


Lys Arg Arg Lys Arg Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn 
            740                 745                 750         


Leu Thr Trp Lys Ser Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro 
        755                 760                 765             


Lys Pro Val Asn Gln Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly 
    770                 775                 780                 


Asp Trp Lys Ser Lys Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu 
785                 790                 795                 800 


Thr Asp Glu Ile Val Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val 
                805                 810                 815     


Phe Ser Tyr Pro Ala Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu 
            820                 825                 830         


Pro Leu Tyr Glu Asn Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn 
        835                 840                 845             


Leu Gly Gln Pro Thr Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val 
    850                 855                 860                 


Asn Val Thr Val Glu Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr 
865                 870                 875                 880 


Phe Leu Ser Leu Arg Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu 
                885                 890                 895     


Tyr Tyr Trp Lys Ser Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn 
            900                 905                 910         


Thr Asn Glu Phe Leu Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe 
        915                 920                 925             


Ser Val Gln Ala Val Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr 
    930                 935                 940                 


Asp Ser Pro Val Glu Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
945                 950                 955                 960 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            980                 985                 990         


Gly Gly Ser Gly Gly Gly Gly Ser  Asp Lys Thr His Thr  Cys Pro Pro 
        995                 1000                 1005             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1010                 1015                 1020             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1025                 1030                 1035             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1040                 1045                 1050             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1055                 1060                 1065             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1070                 1075                 1080             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1085                 1090                 1095             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1100                 1105                 1110             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1115                 1120                 1125             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1130                 1135                 1140             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1145                 1150                 1155             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1160                 1165                 1170             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1175                 1180                 1185             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1190                 1195                 1200             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1205                 1210                 1215             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1220                 1225         


<210>  48
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP protein

<400>  48

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Gly Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Ser Arg 
225                 230                 235                 240 


Thr Ser Gly Ser Pro Gly Leu Gln Glu Phe Asp Ile Lys Leu Ile Asp 
                245                 250                 255     


Thr Val Asp Leu Glu Ser Cys Asn 
            260                 


<210>  49
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  50
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg 
1               5                   10                  15      


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            20                  25                  30          


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        35                  40                  45              


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    50                  55                  60                  


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
65                  70                  75                  80  


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                85                  90                  95      


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            100                 105                 110         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        115                 120                 125             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    130                 135                 140                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            180                 185                 190         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
        195                 200                 205             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    210                 215                 220                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
225                 230                 235                 240 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                245                 250                 255     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            260                 265                 270         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        275                 280                 285             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    290                 295                 300                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
305                 310                 315                 320 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                325                 330                 335     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            340                 345                 350         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        355                 360                 365             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    370                 375                 380                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
385                 390                 395                 400 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                405                 410                 415     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            420                 425                 430         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        435                 440                 445             


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
    450                 455                 460                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
465                 470                 475                 480 


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
                485                 490                 495     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            500                 505                 510         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        515                 520                 525             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    530                 535                 540                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
545                 550                 555                 560 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                565                 570                 575     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585                 590     


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  51

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  52

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Phe 
            20  


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  53

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val Lys 
            20      


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  54

Gly Glu Trp Trp Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Glu Glu Asp 
            20  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cysteine-containing peptide

<400>  55

Gly Gly Gly Ser Gly Cys Gly Gly Gly Ser 
1               5                   10  


<210>  56
<211>  4544
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Leu Thr Pro Pro Leu Leu Leu Leu Leu Pro Leu Leu Ser Ala Leu 
1               5                   10                  15      


Val Ala Ala Ala Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe 
            20                  25                  30          


Ala Cys Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp 
        35                  40                  45              


Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys 
    50                  55                  60                  


Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu 
65                  70                  75                  80  


Gly Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln 
                85                  90                  95      


Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln 
            100                 105                 110         


Gly Asn Cys Ser Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu 
        115                 120                 125             


Asp Gly Pro Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp 
    130                 135                 140                 


Gly Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys 
145                 150                 155                 160 


Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val 
                165                 170                 175     


Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
            180                 185                 190         


Glu Pro Val Asp Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn 
        195                 200                 205             


Ile Leu Ala Thr Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro 
    210                 215                 220                 


Thr Ser Thr Arg Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu 
225                 230                 235                 240 


Thr Val Cys Trp Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu 
                245                 250                 255     


Lys Cys Ala Arg Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr 
            260                 265                 270         


Ile Asn Ile Ser Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp 
        275                 280                 285             


Trp Leu Thr Gly Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile 
    290                 295                 300                 


Phe Val Cys Asn Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu 
305                 310                 315                 320 


Glu Leu Tyr Asn Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys 
                325                 330                 335     


Val Phe Phe Thr Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp 
            340                 345                 350         


Met Asp Gly Gln Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe 
        355                 360                 365             


Pro His Gly Ile Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala 
    370                 375                 380                 


Asp Ala Tyr Leu Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly 
385                 390                 395                 400 


Arg Gln Thr Ile Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu 
                405                 410                 415     


Thr Val Phe Glu Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn 
            420                 425                 430         


Ala Gln Gln Lys Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr 
        435                 440                 445             


Glu Tyr Gln Val Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile 
    450                 455                 460                 


Tyr His Gln Arg Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn 
465                 470                 475                 480 


Asp Gln Tyr Gly Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala 
                485                 490                 495     


Asn Ser His Lys Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu 
            500                 505                 510         


Gly Ser Asp Gly Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu 
        515                 520                 525             


Val Tyr Gly Lys Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly 
    530                 535                 540                 


Ala Lys Val Pro Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn 
545                 550                 555                 560 


Pro Arg Ala Leu Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala 
                565                 570                 575     


Asp Thr Thr Ser Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu 
            580                 585                 590         


Arg Glu Thr Ile Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala 
        595                 600                 605             


Val Asp Trp Met Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys 
    610                 615                 620                 


Lys Thr Ile Ser Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys 
625                 630                 635                 640 


Thr Leu Ile Glu Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp 
                645                 650                 655     


Pro Leu Asn Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys 
            660                 665                 670         


Asp Ser Arg Arg Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His 
        675                 680                 685             


Arg Asp Ile Phe Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu 
    690                 695                 700                 


Ser Leu Asp Ile Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr 
705                 710                 715                 720 


Asp Arg Ile Glu Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val 
                725                 730                 735     


Tyr Glu Gly Pro Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly 
            740                 745                 750         


Asn Tyr Leu Phe Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu 
        755                 760                 765             


Glu Arg Gly Val Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser 
    770                 775                 780                 


Glu Arg Pro Pro Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln 
785                 790                 795                 800 


Gln Val Gly Thr Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser 
                805                 810                 815     


Leu Cys Leu Ala Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp 
            820                 825                 830         


Gln Val Leu Asp Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr 
        835                 840                 845             


Val Pro Pro Pro Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser 
    850                 855                 860                 


Arg Cys Ile Gln Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu 
865                 870                 875                 880 


Asp Asn Ser Asp Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro 
                885                 890                 895     


Ser Asp Arg Phe Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp 
            900                 905                 910         


Leu Cys Asp Gly Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn 
        915                 920                 925             


Ala Thr Cys Ser Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala 
    930                 935                 940                 


Ser Gly Arg Cys Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp 
945                 950                 955                 960 


Cys Gly Asp Arg Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys 
                965                 970                 975     


Phe Pro Leu Thr Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile 
            980                 985                 990         


Asn Trp Arg Cys Asp Asn Asp Asn  Asp Cys Gly Asp Asn  Ser Asp Glu 
        995                 1000                 1005             


Ala Gly  Cys Ser His Ser Cys  Ser Ser Thr Gln Phe  Lys Cys Asn 
    1010                 1015                 1020             


Ser Gly  Arg Cys Ile Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn 
    1025                 1030                 1035             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn 
    1040                 1045                 1050             


Gln Ala  Thr Arg Pro Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln 
    1055                 1060                 1065             


Cys Arg  Leu Asp Gly Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    1070                 1075                 1080             


Gly Asp  Thr Asp Cys Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu 
    1085                 1090                 1095             


Gly Val  Thr His Val Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys 
    1100                 1105                 1110             


Asp Ser  Ala Arg Cys Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp 
    1115                 1120                 1125             


Asn Asp  Cys Glu Asp Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu 
    1130                 1135                 1140             


Ala Cys  Arg Pro Pro Ser His  Pro Cys Ala Asn Asn  Thr Ser Val 
    1145                 1150                 1155             


Cys Leu  Pro Pro Asp Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly 
    1160                 1165                 1170             


Asp Gly  Ser Asp Glu Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn 
    1175                 1180                 1185             


Asn Gly  Gly Cys Ser His Asn  Cys Ser Val Ala Pro  Gly Glu Gly 
    1190                 1195                 1200             


Ile Val  Cys Ser Cys Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn 
    1205                 1210                 1215             


His Thr  Cys Gln Ile Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys 
    1220                 1225                 1230             


Ser Gln  Lys Cys Asp Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys 
    1235                 1240                 1245             


Tyr Glu  Gly Trp Val Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser 
    1250                 1255                 1260             


Leu Asp  Pro Phe Lys Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu 
    1265                 1270                 1275             


Ile Arg  Arg Ile Asp Leu His  Lys Gly Asp Tyr Ser  Val Leu Val 
    1280                 1285                 1290             


Pro Gly  Leu Arg Asn Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln 
    1295                 1300                 1305             


Ser Ala  Leu Tyr Trp Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg 
    1310                 1315                 1320             


Gly Lys  Leu Leu Asp Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val 
    1325                 1330                 1335             


Ile Gln  Tyr Gly Leu Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp 
    1340                 1345                 1350             


Ile Ala  Gly Asn Ile Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile 
    1355                 1360                 1365             


Glu Val  Ala Lys Leu Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala 
    1370                 1375                 1380             


Gly Asp  Ile Glu His Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp 
    1385                 1390                 1395             


Gly Ile  Leu Phe Trp Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile 
    1400                 1405                 1410             


Glu Ala  Ala Ser Met Ser Gly  Ala Gly Arg Arg Thr  Val His Arg 
    1415                 1420                 1425             


Glu Thr  Gly Ser Gly Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr 
    1430                 1435                 1440             


Leu Glu  Lys Arg Ile Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile 
    1445                 1450                 1455             


Tyr Ser  Ala Arg Tyr Asp Gly  Ser Gly His Met Glu  Val Leu Arg 
    1460                 1465                 1470             


Gly His  Glu Phe Leu Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly 
    1475                 1480                 1485             


Gly Glu  Val Tyr Trp Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys 
    1490                 1495                 1500             


Ala Asn  Lys Trp Thr Gly His  Asn Val Thr Val Val  Gln Arg Thr 
    1505                 1510                 1515             


Asn Thr  Gln Pro Phe Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln 
    1520                 1525                 1530             


Pro Met  Ala Pro Asn Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro 
    1535                 1540                 1545             


Cys Ser  His Leu Cys Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys 
    1550                 1555                 1560             


Ala Cys  Pro His Leu Met Lys  Leu His Lys Asp Asn  Thr Thr Cys 
    1565                 1570                 1575             


Tyr Glu  Phe Lys Lys Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile 
    1580                 1585                 1590             


Arg Gly  Val Asp Leu Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser 
    1595                 1600                 1605             


Phe Thr  Val Pro Asp Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp 
    1610                 1615                 1620             


Ala Arg  Glu Gln Arg Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala 
    1625                 1630                 1635             


Ile Lys  Arg Ala Phe Ile Asn  Gly Thr Gly Val Glu  Thr Val Val 
    1640                 1645                 1650             


Ser Ala  Asp Leu Pro Asn Ala  His Gly Leu Ala Val  Asp Trp Val 
    1655                 1660                 1665             


Ser Arg  Asn Leu Phe Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln 
    1670                 1675                 1680             


Ile Asn  Val Ala Arg Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val 
    1685                 1690                 1695             


Gln Gly  Leu Glu Gln Pro His  Gly Leu Val Val His  Pro Leu Arg 
    1700                 1705                 1710             


Gly Lys  Leu Tyr Trp Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn 
    1715                 1720                 1725             


Met Asp  Gly Ser Asn Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly 
    1730                 1735                 1740             


Pro Val  Gly Leu Ala Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp 
    1745                 1750                 1755             


Ile Ser  Ser Gly Asn His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly 
    1760                 1765                 1770             


Ser Gly  Leu Glu Val Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys 
    1775                 1780                 1785             


Ala Thr  Ala Leu Ala Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp 
    1790                 1795                 1800             


Gln Val  Ser Glu Lys Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser 
    1805                 1810                 1815             


Gly Ser  Val Val Leu Arg Asn  Ser Thr Thr Leu Val  Met His Met 
    1820                 1825                 1830             


Lys Val  Tyr Asp Glu Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn 
    1835                 1840                 1845             


Pro Cys  Ser Val Asn Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro 
    1850                 1855                 1860             


Thr Ser  Glu Thr Thr Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser 
    1865                 1870                 1875             


Leu Arg  Ser Gly Gln Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu 
    1880                 1885                 1890             


Leu Tyr  Ser Val His Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro 
    1895                 1900                 1905             


Asn Asp  Lys Ser Asp Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu 
    1910                 1915                 1920             


Ala Val  Gly Ile Asp Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp 
    1925                 1930                 1935             


Val Asp  Met Gly Leu Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln 
    1940                 1945                 1950             


Thr Trp  Arg Glu Asp Val Val  Thr Asn Gly Ile Gly  Arg Val Glu 
    1955                 1960                 1965             


Gly Ile  Ala Val Asp Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp 
    1970                 1975                 1980             


Gln Gly  Phe Asp Val Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe 
    1985                 1990                 1995             


Arg Tyr  Val Val Ile Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile 
    2000                 2005                 2010             


Thr Val  His Pro Glu Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly 
    2015                 2020                 2025             


Gln Tyr  Pro Arg Ile Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg 
    2030                 2035                 2040             


Val Val  Leu Val Asn Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser 
    2045                 2050                 2055             


Val Asp  Tyr Gln Asp Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr 
    2060                 2065                 2070             


Asp Lys  Ile Glu Arg Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu 
    2075                 2080                 2085             


Val Val  Leu Ser Ser Asn Asn  Met Asp Met Phe Ser  Val Ser Val 
    2090                 2095                 2100             


Phe Glu  Asp Phe Ile Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly 
    2105                 2110                 2115             


Ser Ile  Lys Arg Gly Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro 
    2120                 2125                 2130             


Leu Arg  Thr Gly Ile Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe 
    2135                 2140                 2145             


Asn Arg  Asp Arg Gln Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn 
    2150                 2155                 2160             


Gly Gly  Cys Gln Gln Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg 
    2165                 2170                 2175             


Ala Cys  Ala Cys Ala His Gly  Met Leu Ala Glu Asp  Gly Ala Ser 
    2180                 2185                 2190             


Cys Arg  Glu Tyr Ala Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile 
    2195                 2200                 2205             


Leu Lys  Ser Ile His Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro 
    2210                 2215                 2220             


Val Gln  Pro Phe Glu Asp Pro  Glu His Met Lys Asn  Val Ile Ala 
    2225                 2230                 2235             


Leu Ala  Phe Asp Tyr Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn 
    2240                 2245                 2250             


Arg Ile  Phe Phe Ser Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile 
    2255                 2260                 2265             


Asn Asp  Asp Gly Ser Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly 
    2270                 2275                 2280             


Ser Val  Glu Gly Leu Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr 
    2285                 2290                 2295             


Trp Thr  Ser Tyr Thr Thr Ser  Thr Ile Thr Arg His  Thr Val Asp 
    2300                 2305                 2310             


Gln Thr  Arg Pro Gly Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met 
    2315                 2320                 2325             


Ser Gly  Asp Asp His Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln 
    2330                 2335                 2340             


Asn Leu  Met Phe Trp Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile 
    2345                 2350                 2355             


Met Arg  Ala Ala Leu Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu 
    2360                 2365                 2370             


Lys Asp  Ile Arg Thr Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala 
    2375                 2380                 2385             


Glu Lys  Leu Tyr Phe Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg 
    2390                 2395                 2400             


Cys Glu  Tyr Asp Gly Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu 
    2405                 2410                 2415             


Pro Val  His Pro Phe Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe 
    2420                 2425                 2430             


Trp Thr  Asp Trp Val Arg Arg  Ala Val Gln Arg Ala  Asn Lys His 
    2435                 2440                 2445             


Val Gly  Ser Asn Met Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln 
    2450                 2455                 2460             


Pro Met  Gly Ile Ile Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu 
    2465                 2470                 2475             


Leu Ser  Pro Cys Arg Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys 
    2480                 2485                 2490             


Leu Leu  Thr His Gln Gly His  Val Asn Cys Ser Cys  Arg Gly Gly 
    2495                 2500                 2505             


Arg Ile  Leu Gln Asp Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser 
    2510                 2515                 2520             


Cys Arg  Ala Gln Asp Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile 
    2525                 2530                 2535             


Asn Phe  Ser Leu Thr Cys Asp  Gly Val Pro His Cys  Lys Asp Lys 
    2540                 2545                 2550             


Ser Asp  Glu Lys Pro Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys 
    2555                 2560                 2565             


Thr Phe  Arg Gln Cys Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu 
    2570                 2575                 2580             


Trp Cys  Asn Gly Ala Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile 
    2585                 2590                 2595             


Pro Cys  Asn Lys Thr Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg 
    2600                 2605                 2610             


Asp Gly  Thr Cys Ile Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val 
    2615                 2620                 2625             


Asp Cys  Glu Asp Ala Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp 
    2630                 2635                 2640             


Cys Ser  Ser Tyr Phe Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln 
    2645                 2650                 2655             


Pro Cys  Glu Arg Thr Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys 
    2660                 2665                 2670             


Asp Gly  Ala Asn Asp Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys 
    2675                 2680                 2685             


Pro Gly  Val Lys Arg Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys 
    2690                 2695                 2700             


Pro Ser  Gly Arg Cys Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu 
    2705                 2710                 2715             


Asp Asp  Cys Glu His Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe 
    2720                 2725                 2730             


Cys Ser  Glu Ala Gln Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser 
    2735                 2740                 2745             


Lys Gln  Trp Leu Cys Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser 
    2750                 2755                 2760             


Asp Glu  Ala Ala His Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser 
    2765                 2770                 2775             


Phe Ser  Cys Pro Gly Thr His  Val Cys Val Pro Glu  Arg Trp Leu 
    2780                 2785                 2790             


Cys Asp  Gly Asp Lys Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile 
    2795                 2800                 2805             


Ala Ala  Gly Cys Leu Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe 
    2810                 2815                 2820             


Met Cys  Gln Asn Arg Gln Cys  Ile Pro Lys His Phe  Val Cys Asp 
    2825                 2830                 2835             


His Asp  Arg Asp Cys Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys 
    2840                 2845                 2850             


Glu Tyr  Pro Thr Cys Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly 
    2855                 2860                 2865             


Arg Cys  Leu Ser Ser Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp 
    2870                 2875                 2880             


Cys His  Asp Gln Ser Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr 
    2885                 2890                 2895             


Ser Pro  Glu His Lys Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser 
    2900                 2905                 2910             


Ser Gly  Arg Cys Val Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp 
    2915                 2920                 2925             


Asp Cys  Gly Asp Ser Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu 
    2930                 2935                 2940             


Cys Leu  Ser Arg Lys Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp 
    2945                 2950                 2955             


Leu Lys  Ile Gly Phe Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu 
    2960                 2965                 2970             


Lys Asp  Asp Gly Arg Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr 
    2975                 2980                 2985             


Thr Phe  Pro Cys Ser Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr 
    2990                 2995                 3000             


Lys Cys  Leu Cys Val Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro 
    3005                 3010                 3015             


His Ser  Cys Lys Ala Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe 
    3020                 3025                 3030             


Ala Asn  Arg Tyr Tyr Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn 
    3035                 3040                 3045             


Tyr Thr  Leu Leu Lys Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp 
    3050                 3055                 3060             


Phe Asp  Tyr Arg Glu Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr 
    3065                 3070                 3075             


Gln Gly  Ser Met Ile Arg Arg  Met His Leu Asn Gly  Ser Asn Val 
    3080                 3085                 3090             


Gln Val  Leu His Arg Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala 
    3095                 3100                 3105             


Val Asp  Trp Val Gly Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg 
    3110                 3115                 3120             


Asp Thr  Ile Glu Val Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val 
    3125                 3130                 3135             


Leu Val  Ser Ser Gly Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp 
    3140                 3145                 3150             


Val Gln  Asn Gly Tyr Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser 
    3155                 3160                 3165             


Leu Ile  Gly Arg Ile Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile 
    3170                 3175                 3180             


Val Asp  Thr Lys Ile Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr 
    3185                 3190                 3195             


Val Thr  Glu Arg Ile Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile 
    3200                 3205                 3210             


Glu Phe  Ala Ser Leu Asp Gly  Ser Asn Arg His Val  Val Leu Ser 
    3215                 3220                 3225             


Gln Asp  Ile Pro His Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr 
    3230                 3235                 3240             


Val Tyr  Trp Thr Asp Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His 
    3245                 3250                 3255             


Lys Thr  Thr Gly Thr Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His 
    3260                 3265                 3270             


Arg Pro  Met Asp Leu His Val  Phe His Ala Leu Arg  Gln Pro Asp 
    3275                 3280                 3285             


Val Pro  Asn His Pro Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn 
    3290                 3295                 3300             


Leu Cys  Leu Leu Ser Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro 
    3305                 3310                 3315             


Thr Asn  Phe Tyr Leu Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn 
    3320                 3325                 3330             


Cys Thr  Ala Ser Gln Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro 
    3335                 3340                 3345             


Phe Trp  Trp Lys Cys Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser 
    3350                 3355                 3360             


Asp Glu  Pro Pro Asp Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln 
    3365                 3370                 3375             


Phe Gln  Cys Ser Thr Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys 
    3380                 3385                 3390             


Asp Gly  Asp Asn Asp Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys 
    3395                 3400                 3405             


Asp Ile  His Val Cys Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr 
    3410                 3415                 3420             


Asn Arg  Cys Ile Pro Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn 
    3425                 3430                 3435             


Cys Gly  Asp Gly Glu Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys 
    3440                 3445                 3450             


Ala Pro  Asn Gln Phe Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro 
    3455                 3460                 3465             


Arg Val  Trp Val Cys Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser 
    3470                 3475                 3480             


Asp Glu  Pro Ala Asn Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu 
    3485                 3490                 3495             


Phe Arg  Cys Lys Asp Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys 
    3500                 3505                 3510             


Cys Asp  Gly Glu Asp Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys 
    3515                 3520                 3525             


Glu Glu  Cys Asp Glu Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys 
    3530                 3535                 3540             


Lys Asn  Asn Arg Cys Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp 
    3545                 3550                 3555             


Asn Asp  Cys Gly Asp Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg 
    3560                 3565                 3570             


Pro Cys  Ser Glu Ser Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile 
    3575                 3580                 3585             


Ala Gly  Arg Trp Lys Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly 
    3590                 3595                 3600             


Ser Asp  Glu Lys Asp Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe 
    3605                 3610                 3615             


Gln Cys  Lys Ser Gly His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp 
    3620                 3625                 3630             


Ala Asp  Ala Asp Cys Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly 
    3635                 3640                 3645             


Thr Gly  Val Arg Thr Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn 
    3650                 3655                 3660             


Thr Leu  Cys Lys Pro Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp 
    3665                 3670                 3675             


Cys Gly  Asp Asn Ser Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe 
    3680                 3685                 3690             


Val Cys  Pro Pro Asn Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val 
    3695                 3700                 3705             


Cys Leu  Trp Ile Gly Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly 
    3710                 3715                 3720             


Asp Gly  Thr Asp Glu Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr 
    3725                 3730                 3735             


Thr His  Cys Lys Asp Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg 
    3740                 3745                 3750             


Cys Leu  Ser Ser Ser Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly 
    3755                 3760                 3765             


Asp Gly  Ser Asp Glu Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr 
    3770                 3775                 3780             


Ser Cys  Ala Thr Asn Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys 
    3785                 3790                 3795             


Val Arg  Thr Glu Lys Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe 
    3800                 3805                 3810             


His Thr  Val Pro Gly Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys 
    3815                 3820                 3825             


Leu Arg  Phe Gly Thr Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly 
    3830                 3835                 3840             


Gly His  Leu Cys Ser Cys Ala  Arg Asn Phe Met Lys  Thr His Asn 
    3845                 3850                 3855             


Thr Cys  Lys Ala Glu Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala 
    3860                 3865                 3870             


Asp Asp  Asn Glu Ile Arg Ser  Leu Phe Pro Gly His  Pro His Ser 
    3875                 3880                 3885             


Ala Tyr  Glu Gln Ala Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp 
    3890                 3895                 3900             


Ala Met  Asp Val His Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn 
    3905                 3910                 3915             


Trp His  Thr Gly Thr Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala 
    3920                 3925                 3930             


Pro Pro  Thr Thr Ser Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly 
    3935                 3940                 3945             


Val Thr  His Leu Asn Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile 
    3950                 3955                 3960             


Ala Ile  Asp Trp Val Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly 
    3965                 3970                 3975             


Arg Asp  Val Ile Glu Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys 
    3980                 3985                 3990             


Thr Leu  Ile Ser Gly Met Ile  Asp Glu Pro His Ala  Ile Val Val 
    3995                 4000                 4005             


Asp Pro  Leu Arg Gly Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His 
    4010                 4015                 4020             


Pro Lys  Ile Glu Thr Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr 
    4025                 4030                 4035             


Leu Val  Gln Asp Asn Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp 
    4040                 4045                 4050             


Tyr His  Asn Glu Arg Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val 
    4055                 4060                 4065             


Ile Gly  Ser Ile Arg Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala 
    4070                 4075                 4080             


Asp Ser  Lys Arg Gly Leu Ser  His Pro Phe Ser Ile  Asp Val Phe 
    4085                 4090                 4095             


Glu Asp  Tyr Ile Tyr Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe 
    4100                 4105                 4110             


Lys Ile  His Lys Phe Gly His  Ser Pro Leu Val Asn  Leu Thr Gly 
    4115                 4120                 4125             


Gly Leu  Ser His Ala Ser Asp  Val Val Leu Tyr His  Gln His Lys 
    4130                 4135                 4140             


Gln Pro  Glu Val Thr Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp 
    4145                 4150                 4155             


Leu Cys  Leu Leu Ser Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn 
    4160                 4165                 4170             


Gly Lys  Arg Leu Asp Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro 
    4175                 4180                 4185             


Thr Pro  Pro Pro Asp Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln 
    4190                 4195                 4200             


Cys Phe  Asn Gly Gly Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro 
    4205                 4210                 4215             


Lys Cys  Arg Cys Gln Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu 
    4220                 4225                 4230             


Asp Gln  Cys Trp Glu His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala 
    4235                 4240                 4245             


Ser Pro  Ser Gly Met Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr 
    4250                 4255                 4260             


Gly Pro  Lys Cys Thr Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn 
    4265                 4270                 4275             


Asn Ser  Thr Cys Thr Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg 
    4280                 4285                 4290             


Cys Leu  Pro Gly Phe Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys 
    4295                 4300                 4305             


Ser Gly  Tyr Cys Glu Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp 
    4310                 4315                 4320             


Gly Ser  Arg Gln Cys Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg 
    4325                 4330                 4335             


Cys Glu  Val Asn Lys Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val 
    4340                 4345                 4350             


Val Asn  Lys Gln Ser Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly 
    4355                 4360                 4365             


Arg Val  Ala Pro Ser Cys Leu  Thr Cys Val Gly His  Cys Ser Asn 
    4370                 4375                 4380             


Gly Gly  Ser Cys Thr Met Asn  Ser Lys Met Met Pro  Glu Cys Gln 
    4385                 4390                 4395             


Cys Pro  Pro His Met Thr Gly  Pro Arg Cys Glu Glu  His Val Phe 
    4400                 4405                 4410             


Ser Gln  Gln Gln Pro Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu 
    4415                 4420                 4425             


Leu Leu  Leu Leu Leu Leu Val  Leu Val Ala Gly Val  Val Phe Trp 
    4430                 4435                 4440             


Tyr Lys  Arg Arg Val Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg 
    4445                 4450                 4455             


Met Thr  Asn Gly Ala Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr 
    4460                 4465                 4470             


Lys Met  Tyr Glu Gly Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu 
    4475                 4480                 4485             


Asp Ala  Asp Phe Ala Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr 
    4490                 4495                 4500             


Asn Pro  Val Tyr Ala Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg 
    4505                 4510                 4515             


His Ser  Leu Ala Ser Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg 
    4520                 4525                 4530             


Gly Pro  Glu Asp Glu Ile Gly  Asp Pro Leu Ala 
    4535                 4540                 


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biotin Acceptor Peptide

<400>  57

Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lipoate Acceptor Peptide

<400>  58

Gly Phe Glu Ile Asp Lys Val Trp Tyr Asp Leu Asp Ala 
1               5                   10              


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP

<400>  59

Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
1               5                   10                  15      


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25                  


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVII

<400>  60

Ile Val Gly Gly Lys Val 
1               5     


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor X

<400>  61

Ile Val Gly Gly Gln Glu 
1               5      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVII

<400>  62

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu 
1               5                   10  

<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor X

<400>  63

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu 
1               5                   10      


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FX-PABC peptide


<220>
<221>  MOD_RED
<222>  (3)..(3)
<223>  Xaa is DPhe

<220>
<221>  MOD_RED
<222>  (4)..(4)
<223>  Xaa is Pip

<220>
<221>  MOD_RED
<222>  (6)..(6)
<223>  Xaa is P-amino benzyl carbamate


<400>  64

Gly Gly Xaa Xaa Arg Xaa Ile Val Gly Gly Lys Val 
1               5                   10         

