                         SEQUENCE LISTING

<110>  Sylvester, Karl G.
 
<120>  BLOOD BIOMARKERS FOR NECROTIZING ENTEROCOLITIS

<130>  STAN-934

<150>  US 61/657,577
<151>  2012-06-08

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 
1               5                   10                  15      


Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 
            20                  25                  30          


Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 
        35                  40                  45              


Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 
    50                  55                  60                  


Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 
65                  70                  75                  80  


Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 
                85                  90                  95      


Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 
            100                 105                 110         


Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 
        115                 120                 125             


His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala 
    130                 135                 140                 


Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala 
145                 150                 155                 160 


Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp 
                165                 170                 175     


Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 
            180                 185                 190         


Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val 
        195                 200                 205             


Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 
    210                 215                 220                 


Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp 
225                 230                 235                 240 


Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 
                245                 250                 255     


Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 
            260                 265                 270         


Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 
        275                 280                 285             


Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 
    290                 295                 300                 


Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln 
305                 310                 315                 320 


His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe 
                325                 330                 335     


Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 
            340                 345                 350         


Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 
        355                 360                 365             


Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 
    370                 375                 380                 


Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn 
                405                 410                 415     


Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 
            420                 425                 430         


Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys 
        435                 440                 445             


Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val 
    450                 455                 460                 


Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn 
465                 470                 475                 480 


Pro Leu Ser Thr Ala 
                485 


<210>  2
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  3
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  4
<211>  2587
<212>  DNA
<213>  Homo sapiens

<400>  4
atcccatgag cgggcagcag ggtcagaagt ggcccccgtg ttgcctaagc aagactctcc       60

cctgccctct gccctctgca cctccggcct gcatgtccct gtggcctctt gggggtacat      120

ctcccggggc tgggtcagaa ggcctgggtg gttggcctca ggctgtcaca cacctaggga      180

gatgctcccg tttctgggaa ccttggcccc gactcctgca aacttcggta aatgtgtaac      240

tcgaccctgc accggctcac tctgttcagc agtgaaactc tgcatcgatc actaagactt      300

cctggaagag gtcccagcgt gagtgtcgct tctggcatct gtccttctgg ccagcctgtg      360

gtctggccaa gtgatgtaac cctcctctcc agcctgtgca caggcagcct gggaacagct      420

ccatccccac ccctcagcta taaatagggc atcgtgaccc ggccggggga agaagctgcc      480

gttgttctgg gtactacagc agaagggtat gcggaagcga gcaccccagt ctgagatggc      540

tcctgccggt gtgagcctga gggccaccat cctctgcctc ctggcctggg ctggcctggc      600

tgcaggtgac cgggtgtaca tacacccctt ccacctcgtc atccacaatg agagtacctg      660

tgagcagctg gcaaaggcca atgccgggaa gcccaaagac cccaccttca tacctgctcc      720

aattcaggcc aagacatccc ctgtggatga aaaggcccta caggaccagc tggtgctagt      780

cgctgcaaaa cttgacaccg aagacaagtt gagggccgca atggtcggga tgctggccaa      840

cttcttgggc ttccgtatat atggcatgca cagtgagcta tggggcgtgg tccatggggc      900

caccgtcctc tccccaacgg ctgtctttgg caccctggcc tctctctatc tgggagcctt      960

ggaccacaca gctgacaggc tacaggcaat cctgggtgtt ccttggaagg acaagaactg     1020

cacctcccgg ctggatgcgc acaaggtcct gtctgccctg caggctgtac agggcctgct     1080

agtggcccag ggcagggctg atagccaggc ccagctgctg ctgtccacgg tggtgggcgt     1140

gttcacagcc ccaggcctgc acctgaagca gccgtttgtg cagggcctgg ctctctatac     1200

ccctgtggtc ctcccacgct ctctggactt cacagaactg gatgttgctg ctgagaagat     1260

tgacaggttc atgcaggctg tgacaggatg gaagactggc tgctccctga tgggagccag     1320

tgtggacagc accctggctt tcaacaccta cgtccacttc caagggaaga tgaagggctt     1380

ctccctgctg gccgagcccc aggagttctg ggtggacaac agcacctcag tgtctgttcc     1440

catgctctct ggcatgggca ccttccagca ctggagtgac atccaggaca acttctcggt     1500

gactcaagtg cccttcactg agagcgcctg cctgctgctg atccagcctc actatgcctc     1560

tgacctggac aaggtggagg gtctcacttt ccagcaaaac tccctcaact ggatgaagaa     1620

actatctccc cggaccatcc acctgaccat gccccaactg gtgctgcaag gatcttatga     1680

cctgcaggac ctgctcgccc aggctgagct gcccgccatt ctgcacaccg agctgaacct     1740

gcaaaaattg agcaatgacc gcatcagggt gggggaggtg ctgaacagca ttttttttga     1800

gcttgaagcg gatgagagag agcccacaga gtctacccaa cagcttaaca agcctgaggt     1860

cttggaggtg accctgaacc gcccattcct gtttgctgtg tatgatcaaa gcgccactgc     1920

cctgcacttc ctgggccgcg tggccaaccc gctgagcaca gcatgaggcc agggccccag     1980

aacacagtgc ctggcaaggc ctctgcccct ggcctttgag gcaaaggcca gcagcagata     2040

acaaccccgg acaaatcagc gatgtgtcac ccccagtctc ccaccttttc ttctaatgag     2100

tcgactttga gctggaaagc agccgtttct ccttggtcta agtgtgctgc atggagtgag     2160

cagtagaagc ctgcagcggc acaaatgcac ctcccagttt gctgggttta ttttagagaa     2220

tgggggtggg gaggcaagaa ccagtgttta gcgcgggact actgttccaa aaagaattcc     2280

aaccgaccag cttgtttgtg aaacaaaaaa gtgttccctt ttcaagttga gaacaaaaat     2340

tgggttttaa aattaaagta tacatttttg cattgccttc ggtttgtatt tagtgtcttg     2400

aatgtaagaa catgacctcc gtgtagtgtc tgtaatacct tagttttttc cacagatgct     2460

tgtgattttt gaacaatacg tgaaagatgc aagcacctga atttctgttt gaatgcggaa     2520

ccatagctgg ttatttctcc cttgtgttag taataaacgt cttgccacaa taagcctcca     2580

aaaaaaa                                                               2587


<210>  5
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  5
aactctatat agggagttca actggtcacc cagagctgtc ctgtggcctc tgcagctcag       60

catggctagg gtactgggag cacccgttgc actggggttg tggagcctat gctggtctct      120

ggccattgcc acccctcttc ctccgactag tgcccatggg aatgttgctg aaggcgagac      180

caagccagac ccagacgtga ctgaacgctg ctcagatggc tggagctttg atgctaccac      240

cctggatgac aatggaacca tgctgttttt taaaggggag tttgtgtgga agagtcacaa      300

atgggaccgg gagttaatct cagagagatg gaagaatttc cccagccctg tggatgctgc      360

attccgtcaa ggtcacaaca gtgtctttct gatcaagggg gacaaagtct gggtataccc      420

tcctgaaaag aaggagaaag gatacccaaa gttgctccaa gatgaatttc ctggaatccc      480

atccccactg gatgcagctg tggaatgtca ccgtggagaa tgtcaagctg aaggcgtcct      540

cttcttccaa ggtgaccgcg agtggttctg ggacttggct acgggaacca tgaaggagcg      600

ttcctggcca gctgttggga actgctcctc tgccctgaga tggctgggcc gctactactg      660

cttccagggt aaccaattcc tgcgcttcga ccctgtcagg ggagaggtgc ctcccaggta      720

cccgcgggat gtccgagact acttcatgcc ctgccctggc agaggccatg gacacaggaa      780

tgggactggc catgggaaca gtacccacca tggccctgag tatatgcgct gtagcccaca      840

tctagtcttg tctgcactga cgtctgacaa ccatggtgcc acctatgcct tcagtgggac      900

ccactactgg cgtctggaca ccagccggga tggctggcat agctggccca ttgctcatca      960

gtggccccag ggtccttcag cagtggatgc tgccttttcc tgggaagaaa aactctatct     1020

ggtccagggc acccaggtat atgtcttcct gacaaaggga ggctataccc tagtaagcgg     1080

ttatccgaag cggctggaga aggaagtcgg gacccctcat gggattatcc tggactctgt     1140

ggatgcggcc tttatctgcc ctgggtcttc tcggctccat atcatggcag gacggcggct     1200

gtggtggctg gacctgaagt caggagccca agccacgtgg acagagcttc cttggcccca     1260

tgagaaggta gacggagcct tgtgtatgga aaagtccctt ggccctaact catgttccgc     1320

caatggtccc ggcttgtacc tcatccatgg tcccaatttg tactgctaca gtgatgtgga     1380

gaaactgaat gcagccaagg cccttccgca accccagaat gtgaccagtc tcctgggctg     1440

cactcactga ggggccttct gacatgagtc tggcctggcc ccacctccta gttcctcata     1500

ataaagacag attgcttctt cgcttctcac tgaggggcct tctgacatga gtctggcctg     1560

gccccacctc cccagtttct cataataaag acagattgct tcttcacttg aatcaaggga     1620

cctaaaaaaa aaaaa                                                      1635


<210>  6
<211>  4678
<212>  DNA
<213>  Homo sapiens

<400>  6
gcacacagag cagcataaag cccagttgct ttgggaagtg tttgggacca gatggattgt       60

agggagtagg gtacaataca gtctgttctc ctccagctcc ttctttctgc aacatgggga      120

agaacaaact ccttcatcca agtctggttc ttctcctctt ggtcctcctg cccacagacg      180

cctcagtctc tggaaaaccg cagtatatgg ttctggtccc ctccctgctc cacactgaga      240

ccactgagaa gggctgtgtc cttctgagct acctgaatga gacagtgact gtaagtgctt      300

ccttggagtc tgtcagggga aacaggagcc tcttcactga cctggaggcg gagaatgacg      360

tactccactg tgtcgccttc gctgtcccaa agtcttcatc caatgaggag gtaatgttcc      420

tcactgtcca agtgaaagga ccaacccaag aatttaagaa gcggaccaca gtgatggtta      480

agaacgagga cagtctggtc tttgtccaga cagacaaatc aatctacaaa ccagggcaga      540

cagtgaaatt tcgtgttgtc tccatggatg aaaactttca ccccctgaat gagttgattc      600

cactagtata cattcaggat cccaaaggaa atcgcatcgc acaatggcag agtttccagt      660

tagagggtgg cctcaagcaa ttttcttttc ccctctcatc agagcccttc cagggctcct      720

acaaggtggt ggtacagaag aaatcaggtg gaaggacaga gcaccctttc accgtggagg      780

aatttgttct tcccaagttt gaagtacaag taacagtgcc aaagataatc accatcttgg      840

aagaagagat gaatgtatca gtgtgtggcc tatacacata tgggaagcct gtccctggac      900

atgtgactgt gagcatttgc agaaagtata gtgacgcttc cgactgccac ggtgaagatt      960

cacaggcttt ctgtgagaaa ttcagtggac agctaaacag ccatggctgc ttctatcagc     1020

aagtaaaaac caaggtcttc cagctgaaga ggaaggagta tgaaatgaaa cttcacactg     1080

aggcccagat ccaagaagaa ggaacagtgg tggaattgac tggaaggcag tccagtgaaa     1140

tcacaagaac cataaccaaa ctctcatttg tgaaagtgga ctcacacttt cgacagggaa     1200

ttcccttctt tgggcaggtg cgcctagtag atgggaaagg cgtccctata ccaaataaag     1260

tcatattcat cagaggaaat gaagcaaact attactccaa tgctaccacg gatgagcatg     1320

gccttgtaca gttctctatc aacaccacca atgttatggg tacctctctt actgttaggg     1380

tcaattacaa ggatcgtagt ccctgttacg gctaccagtg ggtgtcagaa gaacacgaag     1440

aggcacatca cactgcttat cttgtgttct ccccaagcaa gagctttgtc caccttgagc     1500

ccatgtctca tgaactaccc tgtggccata ctcagacagt ccaggcacat tatattctga     1560

atggaggcac cctgctgggg ctgaagaagc tctccttcta ttatctgata atggcaaagg     1620

gaggcattgt ccgaactggg actcatggac tgcttgtgaa gcaggaagac atgaagggcc     1680

atttttccat ctcaatccct gtgaagtcag acattgctcc tgtcgctcgg ttgctcatct     1740

atgctgtttt acctaccggg gacgtgattg gggattctgc aaaatatgat gttgaaaatt     1800

gtctggccaa caaggtggat ttgagcttca gcccatcaca aagtctccca gcctcacacg     1860

cccacctgcg agtcacagcg gctcctcagt ccgtctgcgc cctccgtgct gtggaccaaa     1920

gcgtgctgct catgaagcct gatgctgagc tctcggcgtc ctcggtttac aacctgctac     1980

cagaaaagga cctcactggc ttccctgggc ctttgaatga ccaggacgat gaagactgca     2040

tcaatcgtca taatgtctat attaatggaa tcacatatac tccagtatca agtacaaatg     2100

aaaaggatat gtacagcttc ctagaggaca tgggcttaaa ggcattcacc aactcaaaga     2160

ttcgtaaacc caaaatgtgt ccacagcttc aacagtatga aatgcatgga cctgaaggtc     2220

tacgtgtagg tttttatgag tcagatgtaa tgggaagagg ccatgcacgc ctggtgcatg     2280

ttgaagagcc tcacacggag accgtacgaa agtacttccc tgagacatgg atctgggatt     2340

tggtggtggt aaactcagca ggtgtggctg aggtaggagt aacagtccct gacaccatca     2400

ccgagtggaa ggcaggggcc ttctgcctgt ctgaagatgc tggacttggt atctcttcca     2460

ctgcctctct ccgagccttc cagcccttct ttgtggagct cacaatgcct tactctgtga     2520

ttcgtggaga ggccttcaca ctcaaggcca cggtcctaaa ctaccttccc aaatgcatcc     2580

gggtcagtgt gcagctggaa gcctctcccg ccttcctagc tgtcccagtg gagaaggaac     2640

aagcgcctca ctgcatctgt gcaaacgggc ggcaaactgt gtcctgggca gtaaccccaa     2700

agtcattagg aaatgtgaat ttcactgtga gcgcagaggc actagagtct caagagctgt     2760

gtgggactga ggtgccttca gttcctgaac acggaaggaa agacacagtc atcaagcctc     2820

tgttggttga acctgaagga ctagagaagg aaacaacatt caactcccta ctttgtccat     2880

caggtggtga ggtttctgaa gaattatccc tgaaactgcc accaaatgtg gtagaagaat     2940

ctgcccgagc ttctgtctca gttttgggag acatattagg ctctgccatg caaaacacac     3000

aaaatcttct ccagatgccc tatggctgtg gagagcagaa tatggtcctc tttgctccta     3060

acatctatgt actggattat ctaaatgaaa cacagcagct tactccagag atcaagtcca     3120

aggccattgg ctatctcaac actggttacc agagacagtt gaactacaaa cactatgatg     3180

gctcctacag cacctttggg gagcgatatg gcaggaacca gggcaacacc tggctcacag     3240

cctttgttct gaagactttt gcccaagctc gagcctacat cttcatcgat gaagcacaca     3300

ttacccaagc cctcatatgg ctctcccaga ggcagaagga caatggctgt ttcaggagct     3360

ctgggtcact gctcaacaat gccataaagg gaggagtaga agatgaagtg accctctccg     3420

cctatatcac catcgccctt ctggagattc ctctcacagt cactcaccct gttgtccgca     3480

atgccctgtt ttgcctggag tcagcctgga agacagcaca agaaggggac catggcagcc     3540

atgtatatac caaagcactg ctggcctatg cttttgccct ggcaggtaac caggacaaga     3600

ggaaggaagt actcaagtca cttaatgagg aagctgtgaa gaaagacaac tctgtccatt     3660

gggagcgccc tcagaaaccc aaggcaccag tggggcattt ttacgaaccc caggctccct     3720

ctgctgaggt ggagatgaca tcctatgtgc tcctcgctta tctcacggcc cagccagccc     3780

caacctcgga ggacctgacc tctgcaacca acatcgtgaa gtggatcacg aagcagcaga     3840

atgcccaggg cggtttctcc tccacccagg acacagtggt ggctctccat gctctgtcca     3900

aatatggagc agccacattt accaggactg ggaaggctgc acaggtgact atccagtctt     3960

cagggacatt ttccagcaaa ttccaagtgg acaacaacaa ccgcctgtta ctgcagcagg     4020

tctcattgcc agagctgcct ggggaataca gcatgaaagt gacaggagaa ggatgtgtct     4080

acctccagac atccttgaaa tacaatattc tcccagaaaa ggaagagttc ccctttgctt     4140

taggagtgca gactctgcct caaacttgtg atgaacccaa agcccacacc agcttccaaa     4200

tctccctaag tgtcagttac acagggagcc gctctgcctc caacatggcg atcgttgatg     4260

tgaagatggt ctctggcttc attcccctga agccaacagt gaaaatgctt gaaagatcta     4320

accatgtgag ccggacagaa gtcagcagca accatgtctt gatttacctt gataaggtgt     4380

caaatcagac actgagcttg ttcttcacgg ttctgcaaga tgtcccagta agagatctga     4440

aaccagccat agtgaaagtc tatgattact acgagacgga tgagtttgca attgctgagt     4500

acaatgctcc ttgcagcaaa gatcttggaa atgcttgaag accacaaggc tgaaaagtgc     4560

tttgctggag tcctgttctc agagctccac agaagacacg tgtttttgta tctttaaaga     4620

cttgatgaat aaacactttt tctggtcaat gtcaaaaaaa aaaaaaaaaa aaaaaaaa       4678


<210>  7
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile 
            420 


<210>  8
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Val Arg Pro Glu His Pro Ala Glu Thr Glu Tyr Asp Ser Leu Tyr 
        435                 440                 445             


Pro Glu Asp Asp Leu 
    450             


<210>  9
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  9
cttctggtaa ggaggccccg tgatcagctc cagccatttg cagtcctggc tatcccagga       60

gcttacataa agggacaatt ggagcctgag aggtgacagt gctgacacta caaggctcgg      120

agctccgggc actcagacat catgagttgg tccttgcacc cccggaattt aattctctac      180

ttctatgctc ttttatttct ctcttcaaca tgtgtagcat atgttgctac cagagacaac      240

tgctgcatct tagatgaaag attcggtagt tattgtccaa ctacctgtgg cattgcagat      300

ttcctgtcta cttatcaaac caaagtagac aaggatctac agtctttgga agacatctta      360

catcaagttg aaaacaaaac atcagaagtc aaacagctga taaaagcaat ccaactcact      420

tataatcctg atgaatcatc aaaaccaaat atgatagacg ctgctacttt gaagtccagg      480

aaaatgttag aagaaattat gaaatatgaa gcatcgattt taacacatga ctcaagtatt      540

cgatatttgc aggaaatata taattcaaat aatcaaaaga ttgttaacct gaaagagaag      600

gtagcccagc ttgaagcaca gtgccaggaa ccttgcaaag acacggtgca aatccatgat      660

atcactggga aagattgtca agacattgcc aataagggag ctaaacagag cgggctttac      720

tttattaaac ctctgaaagc taaccagcaa ttcttagtct actgtgaaat cgatgggtct      780

ggaaatggat ggactgtgtt tcagaagaga cttgatggca gtgtagattt caagaaaaac      840

tggattcaat ataaagaagg atttggacat ctgtctccta ctggcacaac agaattttgg      900

ctgggaaatg agaagattca tttgataagc acacagtctg ccatcccata tgcattaaga      960

gtggaactgg aagactggaa tggcagaacc agtactgcag actatgccat gttcaaggtg     1020

ggacctgaag ctgacaagta ccgcctaaca tatgcctact tcgctggtgg ggatgctgga     1080

gatgcctttg atggctttga ttttggcgat gatcctagtg acaagttttt cacatcccat     1140

aatggcatgc agttcagtac ctgggacaat gacaatgata agtttgaagg caactgtgct     1200

gaacaggatg gatctggttg gtggatgaac aagtgtcacg ctggccatct caatggagtt     1260

tattaccaag gtggcactta ctcaaaagca tctactccta atggttatga taatggcatt     1320

atttgggcca cttggaaaac ccggtggtat tccatgaaga aaaccactat gaagataatc     1380

ccattcaaca gactcacaat tggagaagga cagcaacacc acctgggggg agccaaacag     1440

gctggagacg tttaaaagac cgtttcaaaa gagatttact tttttaaagg actttatctg     1500

aacagagaga tataatattt ttcctattgg acaatggact tgcaaagctt cacttcattt     1560

taagagcaaa agaccccatg ttgaaaactc cataacagtt ttatgctgat gataatttat     1620

ctacatgcat ttcaataaac cttttgtttc ctaagactag aaaaa                     1665


<210>  10
<211>  1763
<212>  DNA
<213>  Homo sapiens

<400>  10
cttctggtaa ggaggccccg tgatcagctc cagccatttg cagtcctggc tatcccagga       60

gcttacataa agggacaatt ggagcctgag aggtgacagt gctgacacta caaggctcgg      120

agctccgggc actcagacat catgagttgg tccttgcacc cccggaattt aattctctac      180

ttctatgctc ttttatttct ctcttcaaca tgtgtagcat atgttgctac cagagacaac      240

tgctgcatct tagatgaaag attcggtagt tattgtccaa ctacctgtgg cattgcagat      300

ttcctgtcta cttatcaaac caaagtagac aaggatctac agtctttgga agacatctta      360

catcaagttg aaaacaaaac atcagaagtc aaacagctga taaaagcaat ccaactcact      420

tataatcctg atgaatcatc aaaaccaaat atgatagacg ctgctacttt gaagtccagg      480

aaaatgttag aagaaattat gaaatatgaa gcatcgattt taacacatga ctcaagtatt      540

cgatatttgc aggaaatata taattcaaat aatcaaaaga ttgttaacct gaaagagaag      600

gtagcccagc ttgaagcaca gtgccaggaa ccttgcaaag acacggtgca aatccatgat      660

atcactggga aagattgtca agacattgcc aataagggag ctaaacagag cgggctttac      720

tttattaaac ctctgaaagc taaccagcaa ttcttagtct actgtgaaat cgatgggtct      780

ggaaatggat ggactgtgtt tcagaagaga cttgatggca gtgtagattt caagaaaaac      840

tggattcaat ataaagaagg atttggacat ctgtctccta ctggcacaac agaattttgg      900

ctgggaaatg agaagattca tttgataagc acacagtctg ccatcccata tgcattaaga      960

gtggaactgg aagactggaa tggcagaacc agtactgcag actatgccat gttcaaggtg     1020

ggacctgaag ctgacaagta ccgcctaaca tatgcctact tcgctggtgg ggatgctgga     1080

gatgcctttg atggctttga ttttggcgat gatcctagtg acaagttttt cacatcccat     1140

aatggcatgc agttcagtac ctgggacaat gacaatgata agtttgaagg caactgtgct     1200

gaacaggatg gatctggttg gtggatgaac aagtgtcacg ctggccatct caatggagtt     1260

tattaccaag gtggcactta ctcaaaagca tctactccta atggttatga taatggcatt     1320

atttgggcca cttggaaaac ccggtggtat tccatgaaga aaaccactat gaagataatc     1380

ccattcaaca gactcacaat tggagaagga cagcaacacc acctgggggg agccaaacag     1440

gtcagaccag agcaccctgc ggaaacagaa tatgactcac tttaccctga ggatgatttg     1500

tagaaaatta actgctaact tctattgacc cacaaagttt cagaaattct ctgaaagttt     1560

cttccttttt tctcttacta tatttattga tttcaagtct tctattaagg acatttagcc     1620

ttcaatggaa attaaaactc atttaggact gtatttccaa attactgata tcagagttat     1680

ttaaaaattg tttatttgag gagataacat ttcaactttg ttcctaaata tataataata     1740

aaatgattga ctttatttgc aaa                                             1763


