                         SEQUENCE LISTING

<110>  Amorfix Life Sciences Ltd.
       Helix BioPharma Corp.
 
<120>  ANTIBODIES AND CONJUGATES THAT TARGET MISFOLDED PRION PROTEIN

<130>  15289-P44183PC00

<140>  PCT/CA2013/000569
<141>  2013-06-11

<150>  61/658,569
<151>  2012-06-12

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  oryctolagus cuniculus

<400>  1

Thr Tyr Ala Met Gly 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  oryctolagus cuniculus

<400>  2

Val Ile Thr Lys Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  3
<211>  10
<212>  PRT
<213>  oryctolagus cuniculus

<400>  3

Tyr Gly Ile Gly Val Ser Tyr Tyr Asp Ile 
1               5                   10  


<210>  4
<211>  13
<212>  PRT
<213>  oryctolagus cuniculus

<400>  4

Gln Ser Ser Gln Ser Leu Tyr Asn Lys Asn Trp Leu Ser 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  oryctolagus cuniculus

<400>  5

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  oryctolagus cuniculus

<400>  6

Gln Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Thr Ala 
1               5                   10              


<210>  7
<211>  134
<212>  PRT
<213>  oryctolagus cuniculus

<400>  7

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Leu Tyr Asn Lys Asn Trp Leu Ser Trp Tyr Gln Lys Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Glu Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Thr Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val 
    130                 


<210>  8
<211>  136
<212>  PRT
<213>  oryctolagus cuniculus

<400>  8

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly His Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Thr Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Val Ile Thr Lys Ser Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly 
            100                 105                 110         


Arg Tyr Gly Ile Gly Val Ser Tyr Tyr Asp Ile Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Gly Gln 
    130                 135     


<210>  9
<211>  239
<212>  PRT
<213>  oryctolagus cuniculus

<400>  9

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Leu Tyr Asn Lys Asn Trp Leu Ser Trp Tyr Gln Lys Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Glu Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Glu Phe Ser Cys Ser Ser Ala Asp Cys Thr Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  10
<211>  457
<212>  PRT
<213>  oryctolagus cuniculus

<400>  10

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly His Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Thr Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Val Ile Thr Lys Ser Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly 
            100                 105                 110         


Arg Tyr Gly Ile Gly Val Ser Tyr Tyr Asp Ile Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser 
        195                 200                 205             


Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro 
225                 230                 235                 240 


Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr 
        275                 280                 285             


Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln 
    290                 295                 300                 


Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His 
305                 310                 315                 320 


Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln 
            340                 345                 350         


Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu 
        355                 360                 365             


Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val 
            420                 425                 430         


Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455         


<210>  11
<211>  1374
<212>  DNA
<213>  synthetic construct

<400>  11
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcacctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gaatcgacct cagtacctat gcaatgggct gggtccgcca ggctccaggg      180

aaggggctgg agtggatcgg agtcattact aaaagtggta acacatacta cgcgagctgg      240

gcgaaaggcc gattcgccat ctccaaaacc tcgaccacgg tggatctaaa gatcaccagt      300

ccgacaaccg aggacacggc cacctatttc tgtggcagat atggtattgg tgtttcttac      360

tatgacatct ggggcccagg cactctggtc accgtctcct cagggcaacc taaggctcca      420

tcagtcttcc cactggcccc ctgctgcggg gacacaccca gctccacggt gaccctgggc      480

tgcctggtca aagggtacct cccggagcca gtgaccgtga cctggaactc gggcaccctc      540

accaatgggg tacgcacctt cccgtccgtc cggcagtcct caggcctcta ctcgctgagc      600

agcgtggtga gcgtgacctc aagcagccag cccgtcacct gcaacgtggc ccacccagcc      660

accaacacca aagtggacaa gaccgttgcg ccctcgacat gcagcaagcc cacgtgccca      720

ccccctgaac tcctgggggg accgtctgtc ttcatcttcc ccccaaaacc caaggacacc      780

ctcatgatct cacgcacccc cgaggtcaca tgcgtggtgg tggacgtgag ccaggatgac      840

cccgaggtgc agttcacatg gtacataaac aacgagcagg tgcgcaccgc ccggccgccg      900

ctacgggagc agcagttcaa cagcacgatc cgcgtggtca gcaccctccc catcgcgcac      960

caggactggc tgaggggcaa ggagttcaag tgcaaagtcc acaacaaggc actcccggcc     1020

cccatcgaga aaaccatctc caaagccaga gggcagcccc tggagccgaa ggtctacacc     1080

atgggccctc cccgggagga gctgagcagc aggtcggtca gcctgacctg catgatcaac     1140

ggcttctacc cttccgacat ctcggtggag tgggagaaga acgggaaggc agaggacaac     1200

tacaagacca cgccggccgt gctggacagc gacggctcct acttcctcta cagcaagctc     1260

tcagtgccca cgagtgagtg gcagcggggc gacgtcttca cctgctccgt gatgcacgag     1320

gccttgcaca accactacac gcagaagtcc atctcccgct ctccgggtaa atga           1374


<210>  12
<211>  720
<212>  DNA
<213>  synthetic construct

<400>  12
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca tcccctgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccagtc cagtcagagt ctttataata agaactggtt atcctggtat      180

cagaagaaac cagggcagcc tcctaagctc ctgatctaca aggcatccac tctggaatct      240

ggggtctcat cgcggttcaa gggcagtgga tctgggacac agttcactct caccatcagc      300

ggcgtgcagt gtgacgatgc tgccacttac tactgtcaag gcgaatttag ttgtagtagt      360

gctgattgta cggctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


<210>  13
<211>  840
<212>  PRT
<213>  canavalia ensiformis

<400>  13

Met Lys Leu Ser Pro Arg Glu Val Glu Lys Leu Gly Leu His Asn Ala 
1               5                   10                  15      


Gly Tyr Leu Ala Gln Lys Arg Leu Ala Arg Gly Val Arg Leu Asn Tyr 
            20                  25                  30          


Thr Glu Ala Val Ala Leu Ile Ala Ser Gln Ile Met Glu Tyr Ala Arg 
        35                  40                  45              


Asp Gly Glu Lys Thr Val Ala Gln Leu Met Cys Leu Gly Gln His Leu 
    50                  55                  60                  


Leu Gly Arg Arg Gln Val Leu Pro Ala Val Pro His Leu Leu Asn Ala 
65                  70                  75                  80  


Val Gln Val Glu Ala Thr Phe Pro Asp Gly Thr Lys Leu Val Thr Val 
                85                  90                  95      


His Asp Pro Ile Ser Arg Glu Asn Gly Glu Leu Gln Glu Ala Leu Phe 
            100                 105                 110         


Gly Ser Leu Leu Pro Val Pro Ser Leu Asp Lys Phe Ala Glu Thr Lys 
        115                 120                 125             


Glu Asp Asn Arg Ile Pro Gly Glu Ile Leu Cys Glu Asp Glu Cys Leu 
    130                 135                 140                 


Thr Leu Asn Ile Gly Arg Lys Ala Val Ile Leu Lys Val Thr Ser Lys 
145                 150                 155                 160 


Gly Asp Arg Pro Ile Gln Val Gly Ser His Tyr His Phe Ile Glu Val 
                165                 170                 175     


Asn Pro Tyr Leu Thr Phe Asp Arg Arg Lys Ala Tyr Gly Met Arg Leu 
            180                 185                 190         


Asn Ile Ala Ala Gly Thr Ala Val Arg Phe Glu Pro Gly Asp Cys Lys 
        195                 200                 205             


Ser Val Thr Leu Val Ser Ile Glu Gly Asn Lys Val Ile Arg Gly Gly 
    210                 215                 220                 


Asn Ala Ile Ala Asp Gly Pro Val Asn Glu Thr Asn Leu Glu Ala Ala 
225                 230                 235                 240 


Met His Ala Val Arg Ser Lys Gly Phe Gly His Glu Glu Glu Lys Asp 
                245                 250                 255     


Ala Ser Glu Gly Phe Thr Lys Glu Asp Pro Asn Cys Pro Phe Asn Thr 
            260                 265                 270         


Phe Ile His Arg Lys Glu Tyr Ala Asn Lys Tyr Gly Pro Thr Thr Gly 
        275                 280                 285             


Asp Lys Ile Arg Leu Gly Asp Thr Asn Leu Leu Ala Glu Ile Glu Lys 
    290                 295                 300                 


Asp Tyr Ala Leu Tyr Gly Asp Glu Cys Val Phe Gly Gly Gly Lys Val 
305                 310                 315                 320 


Ile Arg Asp Gly Met Gly Gln Ser Cys Gly His Pro Pro Ala Ile Ser 
                325                 330                 335     


Leu Asp Thr Val Ile Thr Asn Ala Val Ile Ile Asp Tyr Thr Gly Ile 
            340                 345                 350         


Ile Lys Ala Asp Ile Gly Ile Lys Asp Gly Leu Ile Ala Ser Ile Gly 
        355                 360                 365             


Lys Ala Gly Asn Pro Asp Ile Met Asn Gly Val Phe Ser Asn Met Ile 
    370                 375                 380                 


Ile Gly Ala Asn Thr Glu Val Ile Ala Gly Glu Gly Leu Ile Val Thr 
385                 390                 395                 400 


Ala Gly Ala Ile Asp Cys His Val His Tyr Ile Cys Pro Gln Leu Val 
                405                 410                 415     


Tyr Glu Ala Ile Ser Ser Gly Ile Thr Thr Leu Val Gly Gly Gly Thr 
            420                 425                 430         


Gly Pro Ala Ala Gly Thr Arg Ala Thr Thr Cys Thr Pro Ser Pro Thr 
        435                 440                 445             


Gln Met Arg Leu Met Leu Gln Ser Thr Asp Asp Leu Pro Leu Asn Phe 
    450                 455                 460                 


Gly Phe Thr Gly Lys Gly Ser Ser Ser Lys Pro Asp Glu Leu His Glu 
465                 470                 475                 480 


Ile Ile Lys Ala Gly Ala Met Gly Leu Lys Leu His Glu Asp Trp Gly 
                485                 490                 495     


Ser Thr Pro Ala Ala Ile Asp Asn Cys Leu Thr Ile Ala Glu His His 
            500                 505                 510         


Asp Ile Gln Ile Asn Ile His Thr Asp Thr Leu Asn Glu Ala Gly Phe 
        515                 520                 525             


Val Glu His Ser Ile Ala Ala Phe Lys Gly Arg Thr Ile His Thr Tyr 
    530                 535                 540                 


His Ser Glu Gly Ala Gly Gly Gly His Ala Pro Asp Ile Ile Lys Val 
545                 550                 555                 560 


Cys Gly Ile Lys Asn Val Leu Pro Ser Ser Thr Asn Pro Thr Arg Pro 
                565                 570                 575     


Leu Thr Ser Asn Thr Ile Asp Glu His Leu Asp Met Leu Met Val Cys 
            580                 585                 590         


His His Leu Asp Arg Glu Ile Pro Glu Asp Leu Ala Phe Ala His Ser 
        595                 600                 605             


Arg Ile Arg Lys Lys Thr Ile Ala Ala Glu Asp Val Leu Asn Asp Ile 
    610                 615                 620                 


Gly Ala Ile Ser Ile Ile Ser Ser Asp Ser Gln Ala Met Gly Arg Val 
625                 630                 635                 640 


Gly Glu Val Ile Ser Arg Thr Trp Gln Thr Ala Asp Lys Met Lys Ala 
                645                 650                 655     


Gln Thr Gly Pro Leu Lys Cys Asp Ser Ser Asp Asn Asp Asn Phe Arg 
            660                 665                 670         


Ile Arg Arg Tyr Ile Ala Lys Tyr Thr Ile Asn Pro Ala Ile Ala Asn 
        675                 680                 685             


Gly Phe Ser Gln Tyr Val Gly Ser Val Glu Val Gly Lys Leu Ala Asp 
    690                 695                 700                 


Leu Val Met Trp Lys Pro Ser Phe Phe Gly Thr Lys Pro Glu Met Val 
705                 710                 715                 720 


Ile Lys Gly Gly Met Val Ala Trp Ala Asp Ile Gly Asp Pro Asn Ala 
                725                 730                 735     


Ser Ile Pro Thr Pro Glu Pro Val Lys Met Arg Pro Met Tyr Gly Thr 
            740                 745                 750         


Leu Gly Lys Ala Gly Gly Ala Leu Ser Ile Ala Phe Val Ser Lys Ala 
        755                 760                 765             


Ala Leu Asp Gln Arg Val Asn Val Leu Tyr Gly Leu Asn Lys Arg Val 
    770                 775                 780                 


Glu Ala Val Ser Asn Val Arg Lys Leu Thr Lys Leu Asp Met Lys Leu 
785                 790                 795                 800 


Asn Asp Ala Leu Pro Glu Ile Thr Val Asp Pro Glu Ser Tyr Thr Val 
                805                 810                 815     


Lys Ala Asp Gly Lys Leu Leu Cys Val Ser Glu Ala Thr Thr Val Pro 
            820                 825                 830         


Leu Ser Arg Asn Tyr Phe Leu Phe 
        835                 840 


<210>  14
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  14

Met Asp Glu Tyr Ser Asn Gln Asn Asn 
1               5                   


