                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Mader, Michelle M.
       Parris, Kevin D.
       Apgar, James R.
 
<120>  IMPROVED ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES THEREFOR

<130>  PC071914

<150>  61/660,232
<151>  2012-06-15

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu 
        35                  40                  45              


Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  2
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  2
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctcctat      180

ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagacaagac      300

tatgctatga actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  3
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  4
gacattgaga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactact gctttactcg gcatcctacc ggtacactgg agtccctgat      180

cggttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcagcaa cattatagta ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  5
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Glu Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  6
gaggtccaac tattagaatc gggaggcggt ctggttcagc caggagggag tctcaggctt       60

agttgcgctg cgtcgggatt caccttttca agttacgcaa tgtcatgggt tcgtcaggca      120

ccggggaaag gcttagagtg ggtgtcaact attagctctg gcggtagcta tacgtcgtat      180

cctgactctg tgaagggacg atttacaata agccgggaca attctaaaaa cactttgtac      240

ctacagatga attccttgag agccgaagat accgccgtct actattgtgc gaagcaagat      300

tacgctatga actattgggg tcaagggaca atggtaacgg tatcctcc                   348


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  8
gacattcaaa tgacccaaag cccttcttcc ttaagcgcat cagtaggtga ccgagttaca       60

ataacgtgta aagcgagcca agatgtgagt actgcagtag cgtggtatca gcaaaagcca      120

gggaaggctc cgaaactatt gatttactcc gcctcttaca gatatacggg cgttcctgat      180

aggtttagtg gaagtgggtc gggtacggac tttaccctga ctatatcgtc acttcagcca      240

gaggattttg ctacctacta ttgccaacag cattattcaa caccgtggac attcggccag      300

ggaactaagg tcgaaataaa a                                                321


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Tyr Ala Met Ser 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Asp Tyr Ala Met Asn Tyr 
1               5           


<210>  13
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  13

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  16
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  16
cgaaccgtag cggcaccgtc agtattcata ttccctccat cggacgagca attgaaaagt       60

gggacagctt cggtcgtgtg tctcttgaat aacttttacc ccagagaagc taaggtccag      120

tggaaagttg acaatgcgtt acagagcgga aattctcaag aatccgttac tgaacaggat      180

agtaaggatt ctacgtattc acttagcagt actctgaccc tatcaaaggc agattatgaa      240

aaacacaagg tatacgcctg cgaggtgacg catcaaggct tatccagccc agttacaaaa      300

tcttttaaca ggggtgagtg t                                                321


<210>  17
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  18
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human sequence with substitution mutations

<400>  18
gcctccacaa aaggaccatc tgtttttccc ttggcgccat caagtaaatc tacttccgga       60

ggtaccgctg cgcttggctg cctcgtgaaa gactatttcc cagaacctgt cacagtctcg      120

tggaatagtg gtgctttaac ctcgggcgta catacttttc ctgctgtact tcaatcaagc      180

ggactgtact cattatcgtc tgtagtcacg gtcccgagtt cttcactcgg aacacagact      240

tatatatgca acgttaatca taagcctagc aacaccaagg ttgacaaaaa ggtggaacca      300

aaatcgtgcg ataagacgca cacatgtcca ccctgtcctg caccagaagc tctgggcgcg      360

ccatcggttt tcttgttccc acccaaacct aaggacacgt taatgataag tcgaacgcca      420

gaggtgacat gtgttgtagt ggatgtgagc cacgaagatc cggaagtaaa attcaattgg      480

tatgtagatg gtgttgaagt ccataacgca aaaactaagc cgagggaaga gcagtacaac      540

tctacttata gggtagtctc cgtactaact gtcttgcacc aagattggct aaatgggaag      600

gaatataaat gtaaggtttc aaataaggca ctaccagccc cgatagagaa gacaataagc      660

aaagcgaagg ggcaaccaag agagccccaa gtgtacacct tgcctccgag cagagaggaa      720

atgacaaaaa atcaagtatc ccttacgtgt ctggtaaagg gattttatcc aagtgacata      780

gcagtggagt gggagagtaa cggccagcca gaaaacaatt acaaaaccac tcccccggtt      840

ttagatagcg atgggagttt ctttttgtac tcaaagttga ccgttgacaa gtcacgatgg      900

cagcaaggta atgtatttag ttgttctgtt atgcatgagg ccttacataa tcactacacg      960

cagaaatctc tctccttaag ccccgggaaa                                       990


<210>  19
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CH region with substitution mutations

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser 
1               5                   10  


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Asp Tyr Ala Met Asn Tyr 
1               5           


<210>  23
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  23

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  27

Asp Ile Glu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  28
<211>  405
<212>  DNA
<213>  Mus musculus

<400>  28
atgaactttg tgctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactccg      180

gagaagaggc tggagtgggt cgcaaccatt agtagtggtg gtagttacac ctcctatcca      240

gacagtgtga agggtcgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag acaagactat      360

gctatgaact actggggtca aggaacctca gtcaccgtct cctca                      405


<210>  29
<211>  135
<212>  PRT
<213>  Mus musculus

<400>  29

Met Asn Phe Val Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Ser Val Thr Val Ser Ser 
    130                 135 


<210>  30
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  30
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgaga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctaaactact gctttactcg gcatcctacc ggtacactgg agtccctgat      240

cggttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtcagcaa cattatagta ctccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  31
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  31

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Glu Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Leu Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  32
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  33
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  35
gcttttgata tctggggcca agggacaatg gtcaccgtct cttca                       45


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  37
<211>  46
<212>  DNA
<213>  Homo sapiens

<400>  37
tactttgact actggggcca aggaaccctg gtcaccgtct cctcag                      46


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  39
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  39
tggacgttcg gccaagggac caaggtggaa atcaaac                                37


<210>  40
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  40

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  41
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  41
ctcactttcg gcggagggac caaggtggag atcaaac                                37


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  43
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  43
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gtggtagtta cacctcctat      180

ccagacagtg tgaagggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacaagac      300

tatgctatga actactgggg ccagggcacc ctggtcaccg tgtcctcc                   348


<210>  44
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  45
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  45
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca aggccagtca ggatgtgagt actgctgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcatcctacc ggtacactgg cgtgccttcc      180

cggttctccg gctccggctc tggcaccgac ttcaccctga ccatctcctc cctgcagcct      240

gaggacttcg ccacctacta ctgccagcaa cattatagta ctccatggac ctttggcggt      300

ggaacaaagg tggaaatcaa a                                                321


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  47
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gtggtagtta cacctcctat      180

ccagacagtg tgaagggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacaagac      300

tatgctatga actactgggg ccagggcacc atggtcaccg tgtcctcc                   348


<210>  48
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  48
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga cagagtgacc       60

atcacctgca aggccagtca ggatgtgagt actgctgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcatcctacc ggtacactgg cgtgccttcc      180

cggttctccg gctccggctc tggcaccgac ttcaccctga ccatctcctc cctgcagcct      240

gaggacttcg ccacctacta ctgccagcaa cattatagta ctccatggac ctttggccaa      300

ggaacaaagg tggaaatcaa a                                                321


<210>  49
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  49
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcaaccatt agtagtggtg gtagttacac ctcctatcca      240

gacagtgtga agggtcggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa acaagactat      360

gctatgaact actggggcca gggcaccctg gtcaccgtgt cctcc                      405


<210>  50
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  50

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser 
    130                 135 


<210>  51
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  51
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgac       60

atccagatga cccagtcccc ctcctccctg tccgcctccg tgggcgacag agtgaccatc      120

acctgcaagg ccagtcagga tgtgagtact gctgtggcct ggtatcagca gaagcctggc      180

aaggccccta agctgctgat ctactccgca tcctaccggt acactggcgt gccttcccgg      240

ttctccggct ccggctctgg caccgacttc accctgacca tctcctccct gcagcctgag      300

gacttcgcca cctactactg ccagcaacat tatagtactc catggacctt tggcggtgga      360

acaaaggtgg aaatcaaa                                                    378


<210>  52
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  52

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser 
            100                 105                 110         


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  53
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  53
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcaaccatt agtagtggtg gtagttacac ctcctatcca      240

gacagtgtga agggtcggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa acaagactat      360

gctatgaact actggggcca gggcaccatg gtcaccgtgt cctcc                      405


<210>  54
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VH, murine CDRs

<400>  54

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Met Val Thr Val Ser Ser 
    130                 135 


<210>  55
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  55
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgac       60

atccagatga cccagtcccc ctcctccctg tccgcctccg tgggcgacag agtgaccatc      120

acctgcaagg ccagtcagga tgtgagtact gctgtggcct ggtatcagca gaagcctggc      180

aaggccccta agctgctgat ctactccgca tcctaccggt acactggcgt gccttcccgg      240

ttctccggct ccggctctgg caccgacttc accctgacca tctcctccct gcagcctgag      300

gacttcgcca cctactactg ccagcaacat tatagtactc catggacctt tggccaagga      360

acaaaggtgg aaatcaaa                                                    378


<210>  56
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human VL, murine CDRs

<400>  56

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser 
            100                 105                 110         


Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125     


<210>  57
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CH region with substitution mutations

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  58
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH & J segment; Human CH region with 
       substitution mutations

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  59
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CDRs and human VH, J segment and CH

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  60
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  60
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgac       60

attgagatga cccagtctca caaattcatg tccacatcag taggagacag ggtcagcatc      120

acctgcaagg ccagtcagga tgtgagtact gctgtagcct ggtatcaaca gaaaccagga      180

caatctccta aactactgct ttactcggca tcctaccggt acactggagt ccctgatcgg      240

ttcactggca gtggatctgg gacggatttc actttcacca tcagcagtgt gcaggctgaa      300

gacctggcag tttattactg tcagcaacat tatagtactc cgtggacgtt tggcggtgga      360

acaaaggtgg aaatcaaagg aggcggcggt tcaggcggag gtggctctgg cggtggcgga      420

agctccgaag tgcagctggt ggagtctggg ggaggcttag tgaagcctgg agggtccctg      480

aaactctcct gtgcagcctc tggattcact ttcagtagct atgccatgtc ttgggttcgc      540

cagactccgg agaagaggct ggagtgggtc gcaaccatta gtagtggtgg tagttacacc      600

tcctatccag acagtgtgaa gggtcgattc accatctcca gagacaatgc caagaacacc      660

ctgtacctgc aaatgagcag tctgaggtct gaggacacgg ccatgtatta ctgtgcaaga      720

caagactatg ctatgaacta ctggggccag ggcaccctgg tcaccgtgtc ctctgatcag      780

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgct      840

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      900

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      960

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1080

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1380

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacgcaga agagcctctc cctgtccccg ggtaaa                               1476


<210>  61
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  61

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Asp Ile Glu Met Thr Gln Ser His Lys Phe Met Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Leu Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser 
            100                 105                 110         


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
                165                 170                 175     


Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Thr 
            180                 185                 190         


Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
    210                 215                 220                 


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         


<210>  62
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  62
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcaaccatt agtagtggtg gtagttacac ctcctatcca      240

gacagtgtga agggtcggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa acaagactat      360

gctatgaact actggggcca gggcaccctg gtcaccgtgt cctctggagg cggcggttca      420

ggcggaggtg gctctggcgg tggcggaagc tccgacatcc agatgaccca gtccccctcc      480

tccctgtccg cctccgtggg cgacagagtg accatcacct gcaaggccag tcaggatgtg      540

agtactgctg tggcctggta tcagcagaag cctggcaagg cccctaagct gctgatctac      600

tccgcatcct accggtacac tggcgtgcct tcccggttct ccggctccgg ctctggcacc      660

gacttcaccc tgaccatctc ctccctgcag cctgaggact tcgccaccta ctactgccag      720

caacattata gtactccatg gacctttggc ggtggaacaa aggtggaaat caaagatcag      780

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgct      840

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      900

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      960

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1080

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1380

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacgcaga agagcctctc cctgtccccg ggtaaa                               1476


<210>  63
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  63

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
145                 150                 155                 160 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly 
        195                 200                 205             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln His Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu 
                245                 250                 255     


Ile Lys Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         


<210>  64
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  64
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggcgc gcactccgac       60

atccagatga cccagtcccc ctcctccctg tccgcctccg tgggcgacag agtgaccatc      120

acctgcaagg ccagtcagga tgtgagtact gctgtggcct ggtatcagca gaagcctggc      180

aaggccccta agctgctgat ctactccgca tcctaccggt acactggcgt gccttcccgg      240

ttctccggct ccggctctgg caccgacttc accctgacca tctcctccct gcagcctgag      300

gacttcgcca cctactactg ccagcaacat tatagtactc catggacctt tggcggtgga      360

acaaaggtgg aaatcaaagg aggcggcggt tcaggcggag gtggctctgg cggtggcgga      420

agctccgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg      480

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      540

caggctccag ggaaggggct ggagtgggtc tcaaccatta gtagtggtgg tagttacacc      600

tcctatccag acagtgtgaa gggtcggttc accatctcca gagacaattc caagaacacg      660

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaaa      720

caagactatg ctatgaacta ctggggccag ggcaccctgg tcaccgtgtc ctctgatcag      780

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgct      840

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      900

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      960

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1020

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1080

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1380

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacgcaga agagcctctc cctgtccccg ggtaaa                               1476


<210>  65
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  65

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser 
            100                 105                 110         


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val 
    130                 135                 140                 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
                165                 170                 175     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
            180                 185                 190         


Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         


<210>  66
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  68
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  72
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Ser Gly Ser Tyr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Asp Tyr Ala Met Asn Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human with mouse CDRs.

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


