﻿SEQUENCE LISTING

<110>   NOVARTIS AG
        INSTITUT PASTEUR

<120>   VACCINES FOR SEROGROUP X MENINGOCOCCUS

<130>   P062116WO

<140>   PCT/
<141>   2013-06-14

<150>   US 61/659,595
<151>   2012-06-14

<160>   12

<170>   SeqWin2010, version 1.0

<210>   1
<211>   255
<212>   PRT
<213>   Neisseria meningitidis

<400>   1
Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      

Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu Gln 
            20                  25                  30          

Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              

Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  

Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  

Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      

Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe Gln Thr Glu 
            100                 105                 110         

Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala Lys Arg Gln 
        115                 120                 125             

Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ser Phe Asp Lys Leu 
    130                 135                 140                 

Pro Glu Gly Gly Arg Ala Thr Tyr Arg Gly Thr Ala Phe Gly Ser Asp 
145                 150                 155                 160 

Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln 
                165                 170                 175     

Gly Asn Gly Lys Ile Glu His Leu Lys Ser Pro Glu Leu Asn Val Asp 
            180                 185                 190         

Leu Ala Ala Ala Asp Ile Lys Pro Asp Gly Lys Arg His Ala Val Ile 
        195                 200                 205             

Ser Gly Ser Val Leu Tyr Asn Gln Ala Glu Lys Gly Ser Tyr Ser Leu 
    210                 215                 220                 

Gly Ile Phe Gly Gly Lys Ala Gln Glu Val Ala Gly Ser Ala Glu Val 
225                 230                 235                 240 

Lys Thr Val Asn Gly Ile Arg His Ile Gly Leu Ala Ala Lys Gln 
                245                 250                 255 

<210>   2
<211>   254
<212>   PRT
<213>   Neisseria meningitidis

<400>   2
Cys Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Ala Gly Leu 
1               5                   10                  15      

Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Ser Leu Gln 
            20                  25                  30          

Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys Leu Lys Leu 
        35                  40                  45              

Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp Ser Leu Asn 
    50                  55                  60                  

Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp Phe Ile Arg 
65                  70                  75                  80  

Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser Gly Glu Phe 
                85                  90                  95      

Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val Ala Leu Gln Ile Glu 
            100                 105                 110         

Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile Asn Gln Arg Ser 
        115                 120                 125             

Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu 
    130                 135                 140                 

Pro Asp Gly Lys Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp 
145                 150                 155                 160 

Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly 
                165                 170                 175     

His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln Asn Val Glu Leu 
            180                 185                 190         

Ala Ala Ala Glu Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu 
        195                 200                 205             

Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala 
    210                 215                 220                 

Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys 
225                 230                 235                 240 

Ile Gly Glu Lys Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250                 

<210>   3
<211>   262
<212>   PRT
<213>   Neisseria meningitidis

<400>   3
Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Ala Ala Asp 
1               5                   10                  15      

Ile Gly Thr Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys 
            20                  25                  30          

Asp Lys Gly Leu Lys Ser Leu Thr Leu Glu Asp Ser Ile Pro Gln Asn 
        35                  40                  45              

Gly Thr Leu Thr Leu Ser Ala Gln Gly Ala Glu Lys Thr Phe Lys Ala 
    50                  55                  60                  

Gly Asp Lys Asp Asn Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys 
65                  70                  75                  80  

Ile Ser Arg Phe Asp Phe Val Gln Lys Ile Glu Val Asp Gly Gln Thr 
                85                  90                  95      

Ile Thr Leu Ala Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asn His Ser 
            100                 105                 110         

Ala Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys Thr 
        115                 120                 125             

Asp Ser Leu Ile Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly Gly 
    130                 135                 140                 

Glu His Thr Ala Phe Asn Gln Leu Pro Gly Gly Lys Ala Glu Tyr His 
145                 150                 155                 160 

Gly Lys Ala Phe Ser Ser Asp Asp Pro Asn Gly Arg Leu His Tyr Ser 
                165                 170                 175     

Ile Asp Phe Thr Lys Lys Gln Gly Tyr Gly Arg Ile Glu His Leu Lys 
            180                 185                 190         

Thr Leu Glu Gln Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala Asp 
        195                 200                 205             

Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser Glu 
    210                 215                 220                 

Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln Glu 
225                 230                 235                 240 

Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys Val His Glu Ile 
                245                 250                 255     

Gly Ile Ala Gly Lys Gln 
            260         

<210>   4
<211>   488
<212>   PRT
<213>   Neisseria meningitidis

<400>   4
Met Phe Lys Arg Ser Val Ile Ala Met Ala Cys Ile Phe Ala Leu Ser 
1               5                   10                  15      

Ala Cys Gly Gly Gly Gly Gly Gly Ser Pro Asp Val Lys Ser Ala Asp 
            20                  25                  30          

Thr Leu Ser Lys Pro Ala Ala Pro Val Val Ser Glu Lys Glu Thr Glu 
        35                  40                  45              

Ala Lys Glu Asp Ala Pro Gln Ala Gly Ser Gln Gly Gln Gly Ala Pro 
    50                  55                  60                  

Ser Ala Gln Gly Ser Gln Asp Met Ala Ala Val Ser Glu Glu Asn Thr 
65                  70                  75                  80  

Gly Asn Gly Gly Ala Val Thr Ala Asp Asn Pro Lys Asn Glu Asp Glu 
                85                  90                  95      

Val Ala Gln Asn Asp Met Pro Gln Asn Ala Ala Gly Thr Asp Ser Ser 
            100                 105                 110         

Thr Pro Asn His Thr Pro Asp Pro Asn Met Leu Ala Gly Asn Met Glu 
        115                 120                 125             

Asn Gln Ala Thr Asp Ala Gly Glu Ser Ser Gln Pro Ala Asn Gln Pro 
    130                 135                 140                 

Asp Met Ala Asn Ala Ala Asp Gly Met Gln Gly Asp Asp Pro Ser Ala 
145                 150                 155                 160 

Gly Gly Gln Asn Ala Gly Asn Thr Ala Ala Gln Gly Ala Asn Gln Ala 
                165                 170                 175     

Gly Asn Asn Gln Ala Ala Gly Ser Ser Asp Pro Ile Pro Ala Ser Asn 
            180                 185                 190         

Pro Ala Pro Ala Asn Gly Gly Ser Asn Phe Gly Arg Val Asp Leu Ala 
        195                 200                 205             

Asn Gly Val Leu Ile Asp Gly Pro Ser Gln Asn Ile Thr Leu Thr His 
    210                 215                 220                 

Cys Lys Gly Asp Ser Cys Ser Gly Asn Asn Phe Leu Asp Glu Glu Val 
225                 230                 235                 240 

Gln Leu Lys Ser Glu Phe Glu Lys Leu Ser Asp Ala Asp Lys Ile Ser 
                245                 250                 255     

Asn Tyr Lys Lys Asp Gly Lys Asn Asp Lys Phe Val Gly Leu Val Ala 
            260                 265                 270         

Asp Ser Val Gln Met Lys Gly Ile Asn Gln Tyr Ile Ile Phe Tyr Lys 
        275                 280                 285             

Pro Lys Pro Thr Ser Phe Ala Arg Phe Arg Arg Ser Ala Arg Ser Arg 
    290                 295                 300                 

Arg Ser Leu Pro Ala Glu Met Pro Leu Ile Pro Val Asn Gln Ala Asp 
305                 310                 315                 320 

Thr Leu Ile Val Asp Gly Glu Ala Val Ser Leu Thr Gly His Ser Gly 
                325                 330                 335     

Asn Ile Phe Ala Pro Glu Gly Asn Tyr Arg Tyr Leu Thr Tyr Gly Ala 
            340                 345                 350         

Glu Lys Leu Pro Gly Gly Ser Tyr Ala Leu Arg Val Gln Gly Glu Pro 
        355                 360                 365             

Ala Lys Gly Glu Met Leu Ala Gly Ala Ala Val Tyr Asn Gly Glu Val 
    370                 375                 380                 

Leu His Phe His Thr Glu Asn Gly Arg Pro Tyr Pro Thr Arg Gly Arg 
385                 390                 395                 400 

Phe Ala Ala Lys Val Asp Phe Gly Ser Lys Ser Val Asp Gly Ile Ile 
                405                 410                 415     

Asp Ser Gly Asp Asp Leu His Met Gly Thr Gln Lys Phe Lys Ala Ala 
            420                 425                 430         

Ile Asp Gly Asn Gly Phe Lys Gly Thr Trp Thr Glu Asn Gly Ser Gly 
        435                 440                 445             

Asp Val Ser Gly Lys Phe Tyr Gly Pro Ala Gly Glu Glu Val Ala Gly 
    450                 455                 460                 

Lys Tyr Ser Tyr Arg Pro Thr Asp Ala Glu Lys Gly Gly Phe Gly Val 
465                 470                 475                 480 

Phe Ala Gly Lys Lys Glu Gln Asp 
                485             

<210>   5
<211>   364
<212>   PRT
<213>   Neisseria meningitidis

<400>   5
Met Ser Met Lys His Phe Pro Ser Lys Val Leu Thr Thr Ala Ile Leu 
1               5                   10                  15      

Ala Thr Phe Cys Ser Gly Ala Leu Ala Ala Thr Ser Asp Asp Asp Val 
            20                  25                  30          

Lys Lys Ala Ala Thr Val Ala Ile Val Ala Ala Tyr Asn Asn Gly Gln 
        35                  40                  45              

Glu Ile Asn Gly Phe Lys Ala Gly Glu Thr Ile Tyr Asp Ile Gly Glu 
    50                  55                  60                  

Asp Gly Thr Ile Thr Gln Lys Asp Ala Thr Ala Ala Asp Val Glu Ala 
65                  70                  75                  80  

Asp Asp Phe Lys Gly Leu Gly Leu Lys Lys Val Val Thr Asn Leu Thr 
                85                  90                  95      

Lys Thr Val Asn Glu Asn Lys Gln Asn Val Asp Ala Lys Val Lys Ala 
            100                 105                 110         

Ala Glu Ser Glu Ile Glu Lys Leu Thr Thr Lys Leu Ala Asp Thr Asp 
        115                 120                 125             

Ala Ala Leu Ala Asp Thr Asp Ala Ala Leu Asp Glu Thr Thr Asn Ala 
    130                 135                 140                 

Leu Asn Lys Leu Gly Glu Asn Ile Thr Thr Phe Ala Glu Glu Thr Lys 
145                 150                 155                 160 

Thr Asn Ile Val Lys Ile Asp Glu Lys Leu Glu Ala Val Ala Asp Thr 
                165                 170                 175     

Val Asp Lys His Ala Glu Ala Phe Asn Asp Ile Ala Asp Ser Leu Asp 
            180                 185                 190         

Glu Thr Asn Thr Lys Ala Asp Glu Ala Val Lys Thr Ala Asn Glu Ala 
        195                 200                 205             

Lys Gln Thr Ala Glu Glu Thr Lys Gln Asn Val Asp Ala Lys Val Lys 
    210                 215                 220                 

Ala Ala Glu Thr Ala Ala Gly Lys Ala Glu Ala Ala Ala Gly Thr Ala 
225                 230                 235                 240 

Asn Thr Ala Ala Asp Lys Ala Glu Ala Val Ala Ala Lys Val Thr Asp 
                245                 250                 255     

Ile Lys Ala Asp Ile Ala Thr Asn Lys Ala Asp Ile Ala Lys Asn Ser 
            260                 265                 270         

Ala Arg Ile Asp Ser Leu Asp Lys Asn Val Ala Asn Leu Arg Lys Glu 
        275                 280                 285             

Thr Arg Gln Gly Leu Ala Glu Gln Ala Ala Leu Ser Gly Leu Phe Gln 
    290                 295                 300                 

Pro Tyr Asn Val Gly Arg Phe Asn Val Thr Ala Ala Val Gly Gly Tyr 
305                 310                 315                 320 

Lys Ser Glu Ser Ala Val Ala Ile Gly Thr Gly Phe Arg Phe Thr Glu 
                325                 330                 335     

Asn Phe Ala Ala Lys Ala Gly Val Ala Val Gly Thr Ser Ser Gly Ser 
            340                 345                 350         

Ser Ala Ala Tyr His Val Gly Val Asn Tyr Glu Trp 
        355                 360                 

<210>   6
<211>   248
<212>   PRT
<213>   Neisseria meningitidis

<400>   6
Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro 
1               5                   10                  15      

Leu Asp His Lys Asp Lys Gly Leu Gln Ser Leu Thr Leu Asp Gln Ser 
            20                  25                  30          

Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys 
        35                  40                  45              

Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp 
    50                  55                  60                  

Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln 
65                  70                  75                  80  

Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Val Tyr Lys Gln Ser His 
                85                  90                  95      

Ser Ala Leu Thr Ala Phe Gln Thr Glu Gln Ile Gln Asp Ser Glu His 
            100                 105                 110         

Ser Gly Lys Met Val Ala Lys Arg Gln Phe Arg Ile Gly Asp Ile Ala 
        115                 120                 125             

Gly Glu His Thr Ser Phe Asp Lys Leu Pro Glu Gly Gly Arg Ala Thr 
    130                 135                 140                 

Tyr Arg Gly Thr Ala Phe Gly Ser Asp Asp Ala Gly Gly Lys Leu Thr 
145                 150                 155                 160 

Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly Asn Gly Lys Ile Glu His 
                165                 170                 175     

Leu Lys Ser Pro Glu Leu Asn Val Asp Leu Ala Ala Ala Asp Ile Lys 
            180                 185                 190         

Pro Asp Gly Lys Arg His Ala Val Ile Ser Gly Ser Val Leu Tyr Asn 
        195                 200                 205             

Gln Ala Glu Lys Gly Ser Tyr Ser Leu Gly Ile Phe Gly Gly Lys Ala 
    210                 215                 220                 

Gln Glu Val Ala Gly Ser Ala Glu Val Lys Thr Val Asn Gly Ile Arg 
225                 230                 235                 240 

His Ile Gly Leu Ala Ala Lys Gln 
                245             

<210>   7
<211>   434
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Fusion protein of fHbp

<400>   7
Met Val Ser Ala Val Ile Gly Ser Ala Ala Val Gly Ala Lys Ser Ala 
1               5                   10                  15      

Val Asp Arg Arg Thr Thr Gly Ala Gln Thr Asp Asp Asn Val Met Ala 
            20                  25                  30          

Leu Arg Ile Glu Thr Thr Ala Arg Ser Tyr Leu Arg Gln Asn Asn Gln 
        35                  40                  45              

Thr Lys Gly Tyr Thr Pro Gln Ile Ser Val Val Gly Tyr Asp Arg His 
    50                  55                  60                  

Leu Leu Leu Leu Gly Gln Val Ala Thr Glu Gly Glu Lys Gln Phe Val 
65                  70                  75                  80  

Gly Gln Ile Ala Arg Ser Glu Gln Ala Ala Glu Gly Val Tyr Asn Tyr 
                85                  90                  95      

Ile Thr Val Ala Ser Leu Pro Arg Thr Ala Gly Asp Ile Ala Gly Asp 
            100                 105                 110         

Thr Trp Asn Thr Ser Lys Val Arg Ala Thr Leu Leu Gly Ile Ser Pro 
        115                 120                 125             

Ala Thr Arg Ala Arg Val Lys Ile Val Thr Tyr Gly Asn Val Thr Tyr 
    130                 135                 140                 

Val Met Gly Ile Leu Thr Pro Glu Glu Gln Ala Gln Ile Thr Gln Lys 
145                 150                 155                 160 

Val Ser Thr Thr Val Gly Val Gln Lys Val Ile Thr Leu Tyr Gln Asn 
                165                 170                 175     

Tyr Val Gln Arg Gly Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly 
            180                 185                 190         

Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys 
        195                 200                 205             

Gly Leu Gln Ser Leu Thr Leu Asp Gln Ser Val Arg Lys Asn Glu Lys 
    210                 215                 220                 

Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 

Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg Phe Asp 
                245                 250                 255     

Phe Ile Arg Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu Glu Ser 
            260                 265                 270         

Gly Glu Phe Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr Ala Phe 
        275                 280                 285             

Gln Thr Glu Gln Ile Gln Asp Ser Glu His Ser Gly Lys Met Val Ala 
    290                 295                 300                 

Lys Arg Gln Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr Ser Phe 
305                 310                 315                 320 

Asp Lys Leu Pro Glu Gly Gly Arg Ala Thr Tyr Arg Gly Thr Ala Phe 
                325                 330                 335     

Gly Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala 
            340                 345                 350         

Ala Lys Gln Gly Asn Gly Lys Ile Glu His Leu Lys Ser Pro Glu Leu 
        355                 360                 365             

Asn Val Asp Leu Ala Ala Ala Asp Ile Lys Pro Asp Gly Lys Arg His 
    370                 375                 380                 

Ala Val Ile Ser Gly Ser Val Leu Tyr Asn Gln Ala Glu Lys Gly Ser 
385                 390                 395                 400 

Tyr Ser Leu Gly Ile Phe Gly Gly Lys Ala Gln Glu Val Ala Gly Ser 
                405                 410                 415     

Ala Glu Val Lys Thr Val Asn Gly Ile Arg His Ile Gly Leu Ala Ala 
            420                 425                 430         

Lys Gln 
        

<210>   8
<211>   468
<212>   PRT
<213>   Neisseria meningitidis

<400>   8
Ser Pro Asp Val Lys Ser Ala Asp Thr Leu Ser Lys Pro Ala Ala Pro 
1               5                   10                  15      

Val Val Ser Glu Lys Glu Thr Glu Ala Lys Glu Asp Ala Pro Gln Ala 
            20                  25                  30          

Gly Ser Gln Gly Gln Gly Ala Pro Ser Ala Gln Gly Gly Gln Asp Met 
        35                  40                  45              

Ala Ala Val Ser Glu Glu Asn Thr Gly Asn Gly Gly Ala Ala Ala Thr 
    50                  55                  60                  

Asp Lys Pro Lys Asn Glu Asp Glu Gly Ala Gln Asn Asp Met Pro Gln 
65                  70                  75                  80  

Asn Ala Ala Asp Thr Asp Ser Leu Thr Pro Asn His Thr Pro Ala Ser 
                85                  90                  95      

Asn Met Pro Ala Gly Asn Met Glu Asn Gln Ala Pro Asp Ala Gly Glu 
            100                 105                 110         

Ser Glu Gln Pro Ala Asn Gln Pro Asp Met Ala Asn Thr Ala Asp Gly 
        115                 120                 125             

Met Gln Gly Asp Asp Pro Ser Ala Gly Gly Glu Asn Ala Gly Asn Thr 
    130                 135                 140                 

Ala Ala Gln Gly Thr Asn Gln Ala Glu Asn Asn Gln Thr Ala Gly Ser 
145                 150                 155                 160 

Gln Asn Pro Ala Ser Ser Thr Asn Pro Ser Ala Thr Asn Ser Gly Gly 
                165                 170                 175     

Asp Phe Gly Arg Thr Asn Val Gly Asn Ser Val Val Ile Asp Gly Pro 
            180                 185                 190         

Ser Gln Asn Ile Thr Leu Thr His Cys Lys Gly Asp Ser Cys Ser Gly 
        195                 200                 205             

Asn Asn Phe Leu Asp Glu Glu Val Gln Leu Lys Ser Glu Phe Glu Lys 
    210                 215                 220                 

Leu Ser Asp Ala Asp Lys Ile Ser Asn Tyr Lys Lys Asp Gly Lys Asn 
225                 230                 235                 240 

Asp Gly Lys Asn Asp Lys Phe Val Gly Leu Val Ala Asp Ser Val Gln 
                245                 250                 255     

Met Lys Gly Ile Asn Gln Tyr Ile Ile Phe Tyr Lys Pro Lys Pro Thr 
            260                 265                 270         

Ser Phe Ala Arg Phe Arg Arg Ser Ala Arg Ser Arg Arg Ser Leu Pro 
        275                 280                 285             

Ala Glu Met Pro Leu Ile Pro Val Asn Gln Ala Asp Thr Leu Ile Val 
    290                 295                 300                 

Asp Gly Glu Ala Val Ser Leu Thr Gly His Ser Gly Asn Ile Phe Ala 
305                 310                 315                 320 

Pro Glu Gly Asn Tyr Arg Tyr Leu Thr Tyr Gly Ala Glu Lys Leu Pro 
                325                 330                 335     

Gly Gly Ser Tyr Ala Leu Arg Val Gln Gly Glu Pro Ser Lys Gly Glu 
            340                 345                 350         

Met Leu Ala Gly Thr Ala Val Tyr Asn Gly Glu Val Leu His Phe His 
        355                 360                 365             

Thr Glu Asn Gly Arg Pro Ser Pro Ser Arg Gly Arg Phe Ala Ala Lys 
    370                 375                 380                 

Val Asp Phe Gly Ser Lys Ser Val Asp Gly Ile Ile Asp Ser Gly Asp 
385                 390                 395                 400 

Gly Leu His Met Gly Thr Gln Lys Phe Lys Ala Ala Ile Asp Gly Asn 
                405                 410                 415     

Gly Phe Lys Gly Thr Trp Thr Glu Asn Gly Gly Gly Asp Val Ser Gly 
            420                 425                 430         

Lys Phe Tyr Gly Pro Ala Gly Glu Glu Val Ala Gly Lys Tyr Ser Tyr 
        435                 440                 445             

Arg Pro Thr Asp Ala Glu Lys Gly Gly Phe Gly Val Phe Ala Gly Lys 
    450                 455                 460                 

Lys Glu Gln Asp 
465             

<210>   9
<211>   644
<212>   PRT
<213>   Fusion protein of NHBA

<400>   9
Met Ala Ser Pro Asp Val Lys Ser Ala Asp Thr Leu Ser Lys Pro Ala 
1               5                   10                  15      

Ala Pro Val Val Ser Glu Lys Glu Thr Glu Ala Lys Glu Asp Ala Pro 
            20                  25                  30          

Gln Ala Gly Ser Gln Gly Gln Gly Ala Pro Ser Ala Gln Gly Gly Gln 
        35                  40                  45              

Asp Met Ala Ala Val Ser Glu Glu Asn Thr Gly Asn Gly Gly Ala Ala 
    50                  55                  60                  

Ala Thr Asp Lys Pro Lys Asn Glu Asp Glu Gly Ala Gln Asn Asp Met 
65                  70                  75                  80  

Pro Gln Asn Ala Ala Asp Thr Asp Ser Leu Thr Pro Asn His Thr Pro 
                85                  90                  95      

Ala Ser Asn Met Pro Ala Gly Asn Met Glu Asn Gln Ala Pro Asp Ala 
            100                 105                 110         

Gly Glu Ser Glu Gln Pro Ala Asn Gln Pro Asp Met Ala Asn Thr Ala 
        115                 120                 125             

Asp Gly Met Gln Gly Asp Asp Pro Ser Ala Gly Gly Glu Asn Ala Gly 
    130                 135                 140                 

Asn Thr Ala Ala Gln Gly Thr Asn Gln Ala Glu Asn Asn Gln Thr Ala 
145                 150                 155                 160 

Gly Ser Gln Asn Pro Ala Ser Ser Thr Asn Pro Ser Ala Thr Asn Ser 
                165                 170                 175     

Gly Gly Asp Phe Gly Arg Thr Asn Val Gly Asn Ser Val Val Ile Asp 
            180                 185                 190         

Gly Pro Ser Gln Asn Ile Thr Leu Thr His Cys Lys Gly Asp Ser Cys 
        195                 200                 205             

Ser Gly Asn Asn Phe Leu Asp Glu Glu Val Gln Leu Lys Ser Glu Phe 
    210                 215                 220                 

Glu Lys Leu Ser Asp Ala Asp Lys Ile Ser Asn Tyr Lys Lys Asp Gly 
225                 230                 235                 240 

Lys Asn Asp Gly Lys Asn Asp Lys Phe Val Gly Leu Val Ala Asp Ser 
                245                 250                 255     

Val Gln Met Lys Gly Ile Asn Gln Tyr Ile Ile Phe Tyr Lys Pro Lys 
            260                 265                 270         

Pro Thr Ser Phe Ala Arg Phe Arg Arg Ser Ala Arg Ser Arg Arg Ser 
        275                 280                 285             

Leu Pro Ala Glu Met Pro Leu Ile Pro Val Asn Gln Ala Asp Thr Leu 
    290                 295                 300                 

Ile Val Asp Gly Glu Ala Val Ser Leu Thr Gly His Ser Gly Asn Ile 
305                 310                 315                 320 

Phe Ala Pro Glu Gly Asn Tyr Arg Tyr Leu Thr Tyr Gly Ala Glu Lys 
                325                 330                 335     

Leu Pro Gly Gly Ser Tyr Ala Leu Arg Val Gln Gly Glu Pro Ser Lys 
            340                 345                 350         

Gly Glu Met Leu Ala Gly Thr Ala Val Tyr Asn Gly Glu Val Leu His 
        355                 360                 365             

Phe His Thr Glu Asn Gly Arg Pro Ser Pro Ser Arg Gly Arg Phe Ala 
    370                 375                 380                 

Ala Lys Val Asp Phe Gly Ser Lys Ser Val Asp Gly Ile Ile Asp Ser 
385                 390                 395                 400 

Gly Asp Gly Leu His Met Gly Thr Gln Lys Phe Lys Ala Ala Ile Asp 
                405                 410                 415     

Gly Asn Gly Phe Lys Gly Thr Trp Thr Glu Asn Gly Gly Gly Asp Val 
            420                 425                 430         

Ser Gly Lys Phe Tyr Gly Pro Ala Gly Glu Glu Val Ala Gly Lys Tyr 
        435                 440                 445             

Ser Tyr Arg Pro Thr Asp Ala Glu Lys Gly Gly Phe Gly Val Phe Ala 
    450                 455                 460                 

Gly Lys Lys Glu Gln Asp Gly Ser Gly Gly Gly Gly Ala Thr Tyr Lys 
465                 470                 475                 480 

Val Asp Glu Tyr His Ala Asn Ala Arg Phe Ala Ile Asp His Phe Asn 
                485                 490                 495     

Thr Ser Thr Asn Val Gly Gly Phe Tyr Gly Leu Thr Gly Ser Val Glu 
            500                 505                 510         

Phe Asp Gln Ala Lys Arg Asp Gly Lys Ile Asp Ile Thr Ile Pro Val 
        515                 520                 525             

Ala Asn Leu Gln Ser Gly Ser Gln His Phe Thr Asp His Leu Lys Ser 
    530                 535                 540                 

Ala Asp Ile Phe Asp Ala Ala Gln Tyr Pro Asp Ile Arg Phe Val Ser 
545                 550                 555                 560 

Thr Lys Phe Asn Phe Asn Gly Lys Lys Leu Val Ser Val Asp Gly Asn 
                565                 570                 575     

Leu Thr Met His Gly Lys Thr Ala Pro Val Lys Leu Lys Ala Glu Lys 
            580                 585                 590         

Phe Asn Cys Tyr Gln Ser Pro Met Ala Lys Thr Glu Val Cys Gly Gly 
        595                 600                 605             

Asp Phe Ser Thr Thr Ile Asp Arg Thr Lys Trp Gly Val Asp Tyr Leu 
    610                 615                 620                 

Val Asn Val Gly Met Thr Lys Ser Val Arg Ile Asp Ile Gln Ile Glu 
625                 630                 635                 640 

Ala Ala Lys Gln 
                

<210>   10
<211>   327
<212>   PRT
<213>   Neisseria meningitidis

<400>   10
Ala Thr Asn Asp Asp Asp Val Lys Lys Ala Ala Thr Val Ala Ile Ala 
1               5                   10                  15      

Ala Ala Tyr Asn Asn Gly Gln Glu Ile Asn Gly Phe Lys Ala Gly Glu 
            20                  25                  30          

Thr Ile Tyr Asp Ile Asp Glu Asp Gly Thr Ile Thr Lys Lys Asp Ala 
        35                  40                  45              

Thr Ala Ala Asp Val Glu Ala Asp Asp Phe Lys Gly Leu Gly Leu Lys 
    50                  55                  60                  

Lys Val Val Thr Asn Leu Thr Lys Thr Val Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  

Val Asp Ala Lys Val Lys Ala Ala Glu Ser Glu Ile Glu Lys Leu Thr 
                85                  90                  95      

Thr Lys Leu Ala Asp Thr Asp Ala Ala Leu Ala Asp Thr Asp Ala Ala 
            100                 105                 110         

Leu Asp Ala Thr Thr Asn Ala Leu Asn Lys Leu Gly Glu Asn Ile Thr 
        115                 120                 125             

Thr Phe Ala Glu Glu Thr Lys Thr Asn Ile Val Lys Ile Asp Glu Lys 
    130                 135                 140                 

Leu Glu Ala Val Ala Asp Thr Val Asp Lys His Ala Glu Ala Phe Asn 
145                 150                 155                 160 

Asp Ile Ala Asp Ser Leu Asp Glu Thr Asn Thr Lys Ala Asp Glu Ala 
                165                 170                 175     

Val Lys Thr Ala Asn Glu Ala Lys Gln Thr Ala Glu Glu Thr Lys Gln 
            180                 185                 190         

Asn Val Asp Ala Lys Val Lys Ala Ala Glu Thr Ala Ala Gly Lys Ala 
        195                 200                 205             

Glu Ala Ala Ala Gly Thr Ala Asn Thr Ala Ala Asp Lys Ala Glu Ala 
    210                 215                 220                 

Val Ala Ala Lys Val Thr Asp Ile Lys Ala Asp Ile Ala Thr Asn Lys 
225                 230                 235                 240 

Asp Asn Ile Ala Lys Lys Ala Asn Ser Ala Asp Val Tyr Thr Arg Glu 
                245                 250                 255     

Glu Ser Asp Ser Lys Phe Val Arg Ile Asp Gly Leu Asn Ala Thr Thr 
            260                 265                 270         

Glu Lys Leu Asp Thr Arg Leu Ala Ser Ala Glu Lys Ser Ile Ala Asp 
        275                 280                 285             

His Asp Thr Arg Leu Asn Gly Leu Asp Lys Thr Val Ser Asp Leu Arg 
    290                 295                 300                 

Lys Glu Thr Arg Gln Gly Leu Ala Glu Gln Ala Ala Leu Ser Gly Leu 
305                 310                 315                 320 

Phe Gln Pro Tyr Asn Val Gly 
                325         

<210>   11
<211>   261
<212>   PRT
<213>   Neisseria meningitidis

<400>   11
Cys Ser Ser Gly Ser Gly Ser Gly Gly Gly Gly Val Ala Ala Asp Ile 
1               5                   10                  15      

Gly Thr Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp 
            20                  25                  30          

Lys Gly Leu Lys Ser Leu Thr Leu Glu Asp Ser Ile Ser Gln Asn Gly 
        35                  40                  45              

Thr Leu Thr Leu Ser Ala Gln Gly Ala Glu Lys Thr Phe Lys Val Gly 
    50                  55                  60                  

Asp Lys Asp Asn Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Ile 
65                  70                  75                  80  

Ser Arg Phe Asp Phe Val Gln Lys Ile Glu Val Asp Gly Gln Thr Ile 
                85                  90                  95      

Thr Leu Ala Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His Ser Ala 
            100                 105                 110         

Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys Ile Asp 
        115                 120                 125             

Ser Leu Ile Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly Gly Glu 
    130                 135                 140                 

His Thr Ala Phe Asn Gln Leu Pro Ser Gly Lys Ala Glu Tyr His Gly 
145                 150                 155                 160 

Lys Ala Phe Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile 
                165                 170                 175     

Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Thr 
            180                 185                 190         

Pro Glu Gln Asn Val Glu Leu Ala Ser Ala Glu Leu Lys Ala Asp Glu 
        195                 200                 205             

Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser Glu Glu 
    210                 215                 220                 

Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln Glu Ile 
225                 230                 235                 240 

Ala Gly Ser Ala Thr Val Lys Ile Arg Glu Lys Val His Glu Ile Gly 
                245                 250                 255     

Ile Ala Gly Lys Gln 
            260     

<210>   12
<211>   260
<212>   PRT
<213>   Neisseria meningitidis

<400>   12
Cys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Thr Ala Asp 
1               5                   10                  15      

Ile Gly Thr Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys 
            20                  25                  30          

Asp Lys Gly Leu Lys Ser Leu Thr Leu Glu Asp Ser Ile Ser Gln Asn 
        35                  40                  45              

Gly Thr Leu Thr Leu Ser Ala Gln Gly Ala Glu Lys Thr Tyr Gly Asn 
    50                  55                  60                  

Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Val Ser Arg 
65                  70                  75                  80  

Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln Leu Ile Thr Leu 
                85                  90                  95      

Glu Ser Gly Glu Phe Gln Val Tyr Lys Gln Ser His Ser Ala Leu Thr 
            100                 105                 110         

Ala Leu Gln Thr Glu Gln Glu Gln Asp Pro Glu His Ser Glu Lys Met 
        115                 120                 125             

Val Ala Lys Arg Arg Phe Arg Ile Gly Asp Ile Ala Gly Glu His Thr 
    130                 135                 140                 

Ser Phe Asp Lys Leu Pro Lys Asp Val Met Ala Thr Tyr Arg Gly Thr 
145                 150                 155                 160 

Ala Phe Gly Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp 
                165                 170                 175     

Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Ser Pro 
            180                 185                 190         

Glu Leu Asn Val Asp Leu Ala Val Ala Tyr Ile Lys Pro Asp Glu Lys 
        195                 200                 205             

His His Ala Val Ile Ser Gly Ser Val Leu Tyr Asn Gln Asp Glu Lys 
    210                 215                 220                 

Gly Ser Tyr Ser Leu Gly Ile Phe Gly Glu Lys Ala Gln Glu Val Ala 
225                 230                 235                 240 

Gly Ser Ala Glu Val Glu Thr Ala Asn Gly Ile His His Ile Gly Leu 
                245                 250                 255     

Ala Ala Lys Gln 
            260 

