
                                SEQUENCE LISTING

<110> Mayo Foundation for Medical Education and Research

<120> GENOME EDITING
  

<130> 07039-1174WO1

<150> US 61/701,540       
<151> 2012-09-14  

<150> US 61/663,451       
<151> 2012-06-22  

<160> 156

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 1
cctctggaac ctggaccacg ggcatctgtg actgct                           36

<210> 2
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 2
cctctggaac ctccacgggc atctgtgact gct                              33

<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 3
cctctggaac cacgggcatc tgtgactgct                                  30

<210> 4
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 4
cctctggaac ctgaccacgg gcatctgtga ccgct                            35

<210> 5
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 5
cctctggaac acgggcatct gtgactgct                                   29

<210> 6
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 6
cctctggaac ctgaccacgg gcatctgtga ctgct                            35

<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 7
cctctggaat ctgtgactgc t                                           21

<210> 8
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 8
cctctggaac ctcctctgga acacgggcat ctgtga                           36

<210> 9
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 9
cctctggaac ctgaccacgg gcatctgtga ctgct                            35

<210> 10
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 10
cctctgggca tctgtgactg ct                                          22

<210> 11
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 11
cctctggaac ctacgggcat ctgtgactgc t                                31

<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 12
cctctggaac ctgtgactgc t                                           21

<210> 13
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 13
cctctgggca tctgtgactg ct                                          22

<210> 14
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 14
cctctggaac ctgaccacgg gcatctgtga ctgcc                            35

<210> 15
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 15
cctctggaac cgggcatctg tgactgct                                    28

<210> 16
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 16
cctctggaac ctatacggcc acgggcatct gtgac                            35

<210> 17
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 17
cctctggaac ctggaaccac gggcatctgt gactgc                           36

<210> 18
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 18
aaacctgtcc gcgtgtggcg aaggtcaggg accagt                           36

<210> 19
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 19
aaacctgtcc acgtgtggcg aaggtcaggg accagt                           36

<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 20
aaacctgtcc ggcgaaggtc agggaccagt                                  30

<210> 21
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 21
aaacctgggc gaaggtcagg gaccagt                                     27

<210> 22
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 22
aaacctgtcc gcaggggggt cagggaccag t                                31

<210> 23
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 23
aaacctgtaa acctgaaggt cagggaccag t                                31

<210> 24
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 24
cctctggaac gggcatctgt gactgct                                     27

<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 25
cctctggaac ctgtgactgc t                                           21

<210> 26
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 26
cctctggaac ctcacgggca tctgtgactg ct                               32

<210> 27
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 27
cctctggaac ctgaccacgg gcatctgtga ctgct                            35

<210> 28
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 28
cctctggaac cacgggcatc tgtgactgct                                  30

<210> 29
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 29
cctcctctgg aacgggcatc tgtgact                                     27

<210> 30
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 30
agacgtttct gaggaactga ttcaggaggc ca                               32

<210> 31
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 31
agacgtttct gaggaattca ggaggcca                                    28

<210> 32
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 32
agacgtttct gattcaggag gcca                                        24

<210> 33
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synehetic oligonucleotide

<400> 33
agacgtttga ttcaggaggc ca                                          22

<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 34
agacgtttct gattcaggag gcca                                        24

<210> 35
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 35
agacgtttct gaggaggatt caggaggcca                                  30

<210> 36
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 36
agacgtttcg tgcaggcaac tgcattcagg ag                               32

<210> 37
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 37
agacgtttct ggaggcca                                               18

<210> 38
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 38
agtaactacc tatttctggg agactatgtt ga                               32

<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 39
agtaactacc tatgactatg ttga                                        24

<210> 40
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 40
agtaactacc tagactatgt tga                                         23

<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 41
agtaactacc tagactatgt tga                                         23

<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 42
agtaactacc tatgttga                                               18

<210> 43
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 43
agtaactacc tattttgaga ctatgttga                                   29

<210> 44
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 44
agtaactacc tatctgggag actatgttga                                  30

<210> 45
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 45
agtaactacc tatgtttgag actatgttga                                  30

<210> 46
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 46
tacatactgg agagttagtt gacaaagatg aa                               32

<210> 47
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 47
tacatactgg agagacaaag atgaa                                       25

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 48
tacatactga caaagatgaa                                             20

<210> 49
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 49
gtgagcaccc agcggacctc ctctggaacc tggaccacgg gcatctgtga ctgctgttct 60
gat                                                               63

<210> 50
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 50
atcagaacag cagtcacaga tgcccgtggt ccaggttcca gaggaggtcc gctgggtgct 60
cac                                                               63

<210> 51
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 51
acctcctctg gaacctggac gatatcccca cgggcatctg tgactg                46

<210> 52
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 52
acctcctctg gaacctggac ataacttcgt atagcataca ttatagcaat ttatcacggg 60
catctgtgac tg                                                     72

<210> 53
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 53
acctcctctg gaacctggac ccacgggcat ctgtgactg                        39

<210> 54
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 54
agtcacagat gcccgtgg                                               18

<210> 55
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 55
acagatgccc gtgggatatc gtaaccctgt cacagatgca gatgcccgtg ggatatgtct 60
ggaacc                                                            66

<210> 56
<211> 165
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 56
ctggaaccac agatgcccgt gggatatcgt aaccctgtca cagatgcaga tgcccgtggg 60
atatgtctgg aacctggacg atatcccacg ggcatctgtg actgctgttc tgatatgagc 120
acttgtaagt caccaactga ccatgggctt tcagctagat ggaac                 165

<210> 57
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 57
acctcctctg gaacctggac cacgggcatc tgtgactg                         38

<210> 58
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 58
acctcctctg gaacctggac ataacttcgt atagcataca ttatagcaat ttatcacggg 60
catctgtgac tg                                                     72

<210> 59
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 59
acctcctctg gaacctggac ataacttcgt atagcataca ttaagcaatt tatcacgggc 60
atctgtgact g                                                      71

<210> 60
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 60
acctcctcct atacttcgta tagcatacat tatagcaatt tatcacgggc atctgtgact 60
g                                                                 61

<210> 61
<211> 53
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 61
acctccgtcg tatagcatac attatagcaa tttatcacgg gcatctgtga ctg        53

<210> 62
<211> 13
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 62
catctgtgac cac                                                    13

<210> 63
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 63
acccagaaga cgtttctgag gaactgattc aggaggccac tcaaag                46

<210> 64
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 64
ctttgagtgg cctcctgaat cagttcctca gaaacgtctt ctgggt                46

<210> 65
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 65
ccaccagaga gtaactacct atttctggga gactatgttg acagaggc              48

<210> 66
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 66
gcctctgtca acatagtctc ccagaaatag gtagttactc tctggtgg              48

<210> 67
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 67
ctcctcaaca tacatactgg agagttagtt gacaaagatg aatcatttgt            50

<210> 68
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 68
acaaatgatt catctttgtc aactaactct ccagtatgta tgttgaggag            50

<210> 69
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 69
acccagaaga cgtttctgag gagtcaggag gccactcaaa g                     41

<210> 70
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 70
acccagaaga cgtttctgag gattcaggag gccactcaaa g                     41

<210> 71
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 71
acccagaaga cgtgattcag gaggccactc aaag                             34

<210> 72
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 72
acccagaaga cgtttctgat tcaggaggcc actcaaag                         38

<210> 73
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 73
acccagaaga cgtttctgat tcaggaggcc actcaaag                         38

<210> 74
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 74
acccagaaga cgcttctgat tcaggaggcc actcaaag                         38

<210> 75
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 75
ccaccagaga gtaactacct attgggagac tatgttgaca gaggc                 45

<210> 76
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 76
ccaccagaga gtaactacct atgttgacag aggc                             34

<210> 77
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 77
ccaccagaga gtaactacct atggagacta tgttgacaga ggc                   43

<210> 78
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 78
ccaccagaga gtaactacct agactatgtt gacagaggc                        39

<210> 79
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 79
ccaccagaga gtaactacct actgtagact atgttgacag aggc                  44

<210> 80
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 80
ccaccagaga gtaactacct agagactatg ttgacagagg c                     41

<210> 81
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 81
ctcctcaaca tacatactgg agagtatgac aaagatgaat catttgt               47

<210> 82
<211> 50
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 82
ctcctcaaca tacatactgg agagtatgta caaaagatga atcatttgac            50

<210> 83
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 83
ctcctcaaca tacatactgg agagaaagat gaatcatttg t                     41

<210> 84
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 84
ctcctcaaca tacatactgg agagacaaag atgaatcatt tgt                   43

<210> 85
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 85
ctcctcaaca tacatactgg agagatgaca aagatgaatc atttgt                46

<210> 86
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 86
ctcctcaaca tacatactgg agacaaagat gaatcatttg t                     41

<210> 87
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 87
ctcctcaaca tacatactgg agagacaaag atgaatcatt tgt                   43

<210> 88
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 88
ctcctcaaca tacatactga caaagatgaa tcatttgt                         38

<210> 89
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 89
gctccatgtc aaatctgcag ctccacgctt cacgcctcag caaacacaga gtcagaggca 60
gaggcagagg attgcatatc tccttttctc gaaaagtaag                       100

<210> 90
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 90
cttacttttc gagaaaagga gatatgcaat cctctgcctc tgcctctgac tctgtgtttg 60
ctgaggcgtg aagcgtggag ctgcagattt gacatggagc                       100

<210> 91
<211> 88
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 91
tcaaatctgc agctccacgc ttcacgcata acttcgtata gcatacatta tagcaattta 60
tgcatatctc cttttctcga aaagtaag                                    88

<210> 92
<211> 104
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 92
gctccatgtc aaatctgcag ctccacgctt cacgcataac ttcgtatagc atacattata 60
gcaatttatg catatctcct tttctcgaaa agtaagctta tctc                  104

<210> 93
<211> 108
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 93
gctccatgtc aaatctgcag ctccacgctt cacgcctcag caaacacaga gtcagaggca 60
gaggcagagg attgcatatc tccttttctc gaaaagtaag cttatctc              108

<210> 94
<211> 92
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 94
gctccatgtc aaatctgcag ctccacactt cgtatagcat acattatagc aatttatgca 60
tatctccttt tctcgaaaag taagcttatc tc                               92

<210> 95
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 95
agagtcagag gcagaggatt gcatatctcc ttttctc                          37

<210> 96
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 96
gctccatgtc aaatctgcag ctccacgctt cacggcatat ctccttttct cgaaaagtaa 60
gcttatctc                                                         69

<210> 97
<211> 109
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 97
agatatgcat aaattgctat aatgtatgct atacgaagtt atgcgtctta cttttcgaga 60
aaaggagata tgtgttttca cgcaaacaca gagtcagagg cagaggatt             109

<210> 98
<211> 88
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 98
agctataaaa ggagcataac tataaaagga gcatagtctc cttttctcct ctgttggctt 60
tctccactgt tattgttaaa attcacgc                                    88

<210> 99
<211> 73
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 99
cttgtgtttc tcataacttt tgtgttttca tatacacttt tactttttag caattctcct 60
acaggctaca cgc                                                    73

<210> 100
<211> 98
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 100
gctccatgtc aaatctgcag ctccacgctt cacgcataac ttcgtatagc atacattata 60
gcaatttatg catatctcct tttctcgaaa cttatctc                         98

<210> 101
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 101
tacgcttcac aaacacagag tcagaggcag aggattgcat atctcctttt ctcgaaaagt 60
aag                                                               63

<210> 102
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 102
tcgaggctac acgc                                                   14

<210> 103
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 103
gaaacacaga gtcagaggca gaggattgca tatctccttt tctcgaa               47

<210> 104
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 104
Met Ala Ser Ser Pro Pro Lys Lys Lys Arg Lys Val Ser Trp Lys Asp
 1               5                  10                  15      
Ala Ser Gly Trp Ser Arg Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln
            20                  25                  30          
Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln
        35                  40                  45              
His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val
    50                  55                  60                  
Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr
65                  70                  75                  80  
Gln His Ile Ile Thr Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val
                85                  90                  95      
Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu
            100                 105                 110         
Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly
        115                 120                 125             
Gln Leu Val Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala
    130                 135                 140                 
Val His Ala Ser Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr
145                 150                 155                 160 
Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala
                165                 170                 175     
Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala
            180                 185                 190         
Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg
        195                 200                 205             
Pro Ala Met Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu
    210                 215                 220                 
Ile Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val
225                 230                 235                 240 
Ala Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser
                245                 250                 255     
Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu
            260                 265                 270         
Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys
        275                 280                 285             
Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu
    290                 295                 300                 
Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro
305                 310                 315                 320 
Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr
                325                 330                 335     
Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu
            340                 345                 350         
Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val
        355                 360                 365             
Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His
    370                 375                 380                 
Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr
385                 390                 395                 400 
Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly
                405                 410                 415     
Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys
            420                 425                 430         
Phe Asn Asn Gly Glu Ile Asn Phe
        435                 440 


<210> 105
<211> 459
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 105
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp
 1               5                  10                  15      
Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val
            20                  25                  30          
Gly Ile His Arg Gly Val Pro Met Val Asp Leu Arg Thr Leu Gly Tyr
        35                  40                  45              
Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val
    50                  55                  60                  
Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His
65                  70                  75                  80  
Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val
                85                  90                  95      
Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala
            100                 105                 110         
Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala
        115                 120                 125             
Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp
    130                 135                 140                 
Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val
145                 150                 155                 160 
Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn
                165                 170                 175     
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg
            180                 185                 190         
Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala
        195                 200                 205             
Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly
    210                 215                 220                 
Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro
225                 230                 235                 240 
Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser His
                245                 250                 255     
Arg Val Ala Gly Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys
            260                 265                 270         
Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu
        275                 280                 285             
Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met
    290                 295                 300                 
Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His
305                 310                 315                 320 
Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser
                325                 330                 335     
Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly
            340                 345                 350         
Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu
        355                 360                 365             
Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys
    370                 375                 380                 
Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly
385                 390                 395                 400 
His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile
                405                 410                 415     
Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly
            420                 425                 430         
Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg
        435                 440                 445             
Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg Ser
    450                 455                 


<210> 106
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 106
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
            20                  25                  30          
His Gly
        


<210> 107
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 107
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 108
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 108
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala
            20                  25                  30          
His Gly
        


<210> 109
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 109
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 110
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 110
Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 111
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 111
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 112
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 112
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Asn Asn Asn Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 113
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 113
Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys
 1               5                  10                  15      
Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp
            20                  25                  30          
His Gly
        


<210> 114
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 114
Ala Cys Cys Thr Cys Cys Thr Cys Thr Gly Gly Ala Ala Cys Cys Gly
 1               5                  10                  15      
Ala Thr Ala Thr Cys Cys Cys Cys Ala Cys Gly Gly Gly Cys Ala Thr
            20                  25                  30          
Cys Thr Gly Thr Gly Ala Cys Thr Gly
        35                  40      


<210> 115
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 115
Ala Cys Cys Thr Cys Cys Thr Cys Thr Gly Gly Ala Cys Gly Ala Thr
 1               5                  10                  15      
Ala Thr Cys Cys Cys Cys Ala Cys Gly Gly Gly Cys Ala Thr Cys Thr
            20                  25                  30          
Gly Thr Gly Ala Cys Thr Gly
        35                  


<210> 116
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 116
Ala Cys Ala Gly Ala Thr Gly Cys Cys Cys Gly Thr Gly Gly
 1               5                  10                  


<210> 117
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 117
cgtggggata tcgtccaggt tccagag                                     27

<210> 118
<211> 80
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 118
cagcaatttc tactacggtt gtcagtacgc aacgcacgtc gtcaggaacc tggacgatat 60
cccacgggca tctgtgactg                                             80

<210> 119
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic polypeptide

<400> 119
cggacctcct ctggaacctg gacgatatcc cacgggcaac tctgacagtt cttcggatat 60
gagcacttgt aagtcacc                                               78

<210> 120
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 120
ttctactacg gttgtgagca cccagcggac ctcctctgga acctggacga tatcccacgg 60
gcatctgtga ctgctgttct gatatgagca cttgtaagtc                       100

<210> 121
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 121
acctcctctg gaacctggac ataacttcgt atagcataca ttatagcaat ttatcacggg 60
catctgtgac tg                                                     72

<210> 122
<211> 107
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 122
cagcaatttc tactacggtt gtcagtacgc aacgcacgtc gtcaggaacc tggacataac 60
ttcgtatagc atacattata gcaatttatc acgggcatct gtgactg               107

<210> 123
<211> 105
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 123
cggacctcct ctggaacctg gacataactt cgtatagcat acattatagc aatttatcac 60
gggcaactct gacagttctt cggatatgag cacttgtaag tcacc                 105

<210> 124
<211> 24
<212> DNA
<213> Danio rerio

<400> 124
gtgagcaccc agcggacctc ctct                                        24

<210> 125
<211> 21
<212> DNA
<213> Danio rerio

<400> 125
atcagaacaa cagtcagaga t                                           21

<210> 126
<211> 18
<212> DNA
<213> Danio rerio

<400> 126
ggaacctgga ccacgggc                                               18

<210> 127
<211> 24
<212> DNA
<213> Danio rerio

<400> 127
tgcaacactg agctctgtaa acct                                        24

<210> 128
<211> 24
<212> DNA
<213> Danio rerio

<400> 128
ctgctgccga ctggaccctg aggt                                        24

<210> 129
<211> 15
<212> DNA
<213> Danio rerio

<400> 129
gtccgcgtgt ggcga                                                  15

<210> 130
<211> 15
<212> DNA
<213> Danio rerio

<400> 130
acccagaaga cgttt                                                  15

<210> 131
<211> 16
<212> DNA
<213> Danio rerio

<400> 131
ctttgagtgg cctcct                                                 16

<210> 132
<211> 15
<212> DNA
<213> Danio rerio

<400> 132
ctgaggaact gattc                                                  15

<210> 133
<211> 18
<212> DNA
<213> Danio rerio

<400> 133
ctcctcaaca tacatact                                               18

<210> 134
<211> 17
<212> DNA
<213> Danio rerio

<400> 134
gcctctgtca acatagt                                                17

<210> 135
<211> 14
<212> DNA
<213> Danio rerio

<400> 135
cctatttctg ggag                                                   14

<210> 136
<211> 18
<212> DNA
<213> Danio rerio

<400> 136
ctcctcaaca tacatact                                               18

<210> 137
<211> 16
<212> DNA
<213> Danio rerio

<400> 137
acaaatgatt catctt                                                 16

<210> 138
<211> 16
<212> DNA
<213> Danio rerio

<400> 138
ggagagttag ttgaca                                                 16

<210> 139
<211> 23
<212> DNA
<213> Danio rerio

<400> 139
gtcaaatctg cagctccacg ctt                                         23

<210> 140
<211> 19
<212> DNA
<213> Danio rerio

<400> 140
cctctgcctc tgactctgt                                              19

<210> 141
<211> 15
<212> DNA
<213> Danio rerio

<400> 141
cacgcctcag caaac                                                  15

<210> 142
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 142
gttcacacaa aatgtctctc aagtctctaa atc                              33

<210> 143
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 143
agtggccagt gagtgtatgt tacct                                       25

<210> 144
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 144
cgtgaaagag acagcgaagg gattg                                       25

<210> 145
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 145
agaaactacc attgtcacac tgagcgaag                                   29

<210> 146
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 146
gttacggctc aagacgtc                                               18

<210> 147
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 147
caggatgccc tctttaac                                               18

<210> 148
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 148
gatgttcatg gtcagtac                                               18

<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 149
tgattgaggc acattcatgg                                             20

<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 150
ttgttgtcct tgcaaagctg                                             20

<210> 151
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 151
tctagaggat tcgctgat                                               18

<210> 152
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 152
ccctgattgt ggaacttttc agaacgta                                    28

<210> 153
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 153
tggtttggaa ttagtgcagc atgagta                                     27

<210> 154
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 154
taacttcgta tagcatacat tatagcaatt tat                              33

<210> 155
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 155
ataaattgct ataatgtatg ctatacgaag t                                31

<210> 156
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 156
acttcgtata gcatacatta tagcaattta t                                31

