                               SEQUENCE LISTING

<110> THOMAS JEFFERSON UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ABERRANT 
      LIPOGENIC SIGNALING

<130> 003252-071731-PCT

<140>
<141>

<150> 61/663,875
<151> 2012-06-25

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 1177
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Gly Glu 
            20                  25                  30          


Val Gly Ala Gly Arg Gly Arg Ala Asn Gly Leu Asp Ala Pro Arg Ala 
        35                  40                  45              


Gly Ala Asp Arg Gly Ala Met Asp Cys Thr Phe Glu Asp Met Leu Gln 
    50                  55                  60                  


Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp Pro Pro 
65                  70                  75                  80  


Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro Asp Thr 
                85                  90                  95      


Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser Ser Ser 
            100                 105                 110         


Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro Leu Ser 
        115                 120                 125             


Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser Met Pro 
    130                 135                 140                 


Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro Leu Ser 
145                 150                 155                 160 


Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu Leu Pro 
                165                 170                 175     


Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr Pro Val 
            180                 185                 190         


Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser Pro Pro 
        195                 200                 205             


Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser Pro Pro 
    210                 215                 220                 


Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val Val Pro 
225                 230                 235                 240 


Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro Val Thr 
                245                 250                 255     


Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu Gln Pro 
            260                 265                 270         


His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys Thr Asp 
        275                 280                 285             


Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser Gly Thr 
    290                 295                 300                 


Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly Thr Ile 
305                 310                 315                 320 


Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro Ile Asn 
                325                 330                 335     


Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser Arg Gly 
            340                 345                 350         


Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg Ser Ser 
        355                 360                 365             


Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly Thr Glu 
    370                 375                 380                 


Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp Tyr Ile 
385                 390                 395                 400 


Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn Leu Ser 
                405                 410                 415     


Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu Val Ser 
            420                 425                 430         


Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly Val Lys 
        435                 440                 445             


Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala Gly Ser 
    450                 455                 460                 


Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe Glu Asp 
                485                 490                 495     


Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg Gly Met 
            500                 505                 510         


Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu Cys Leu 
        515                 520                 525             


Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu Pro Ser 
    530                 535                 540                 


Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn Val Leu 
545                 550                 555                 560 


Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu Leu Pro 
                565                 570                 575     


Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser Leu Val 
            580                 585                 590         


Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser Gly Pro 
        595                 600                 605             


Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp Leu Ala 
    610                 615                 620                 


Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala Leu Arg 
625                 630                 635                 640 


Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala Cys Ser 
                645                 650                 655     


Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp Val Gly 
            660                 665                 670         


Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys Ala Leu 
        675                 680                 685             


Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val Tyr His 
    690                 695                 700                 


Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly His Leu 
705                 710                 715                 720 


Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu Cys Ala 
                725                 730                 735     


Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val Ala Ala 
            740                 745                 750         


Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe Leu Thr 
        755                 760                 765             


Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln Ser Gly 
    770                 775                 780                 


Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly His Arg 
785                 790                 795                 800 


Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp Glu Ser 
                805                 810                 815     


Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln Val Thr 
            820                 825                 830         


Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys Val Thr 
        835                 840                 845             


Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu Phe Ser 
    850                 855                 860                 


Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp Ala Ala 
865                 870                 875                 880 


Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala Thr Thr 
                885                 890                 895     


Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr Ala Val 
            900                 905                 910         


Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg Leu Cys 
        915                 920                 925             


Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu Arg Pro 
    930                 935                 940                 


Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala Leu Leu 
945                 950                 955                 960 


Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile Cys Glu 
                965                 970                 975     


Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro Ala Ser 
            980                 985                 990         


Ser Ser Ile Asp Lys Ala Val Gln  Leu Phe Leu Cys Asp  Leu Leu Leu 
        995                 1000                 1005             


Val Val  Arg Thr Ser Leu Trp  Arg Gln Gln Gln Pro  Pro Ala Pro 
    1010                 1015                 1020             


Ala Pro  Ala Ala Gln Gly Thr  Ser Ser Arg Pro Gln  Ala Ser Ala 
    1025                 1030                 1035             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1040                 1045                 1050             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1055                 1060                 1065             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1070                 1075                 1080             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1085                 1090                 1095             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1100                 1105                 1110             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1115                 1120                 1125             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1130                 1135                 1140             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1145                 1150                 1155             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1160                 1165                 1170             


Val Thr  Ser Ser 
    1175         


<210> 2
<211> 5012
<212> DNA
<213> Homo sapiens

<400> 2
agcagagctg cggccggggg aacccagttt ccgaggaact tttcgccggc gccgggccgc       60

ctctgaggcc agggcaggac acgaacgcgc ggagcggcgg cggcgactga gagccggggc      120

cgcggcggcg ctccctagga agggccgtac gaggcggcgg gcccggcggg cctcccggag      180

gaggcggctg cgccatggac gagccaccct tcagcgaggc ggctttggag caggcgctgg      240

gcgagccgtg cgatctggac gcggcgctgc tgaccgacat cgaaggtgaa gtcggcgcgg      300

ggaggggtag ggccaacggc ctggacgccc caagggcggg cgcagatcgc ggagccatgg      360

attgcacttt cgaagacatg cttcagctta tcaacaacca agacagtgac ttccctggcc      420

tatttgaccc accctatgct gggagtgggg cagggggcac agaccctgcc agccccgata      480

ccagctcccc aggcagcttg tctccacctc ctgccacatt gagctcctct cttgaagcct      540

tcctgagcgg gccgcaggca gcgccctcac ccctgtcccc tccccagcct gcacccactc      600

cattgaagat gtacccgtcc atgcccgctt tctcccctgg gcctggtatc aaggaagagt      660

cagtgccact gagcatcctg cagaccccca ccccacagcc cctgccaggg gccctcctgc      720

cacagagctt cccagcccca gccccaccgc agttcagctc cacccctgtg ttaggctacc      780

ccagccctcc gggaggcttc tctacaggaa gccctcccgg gaacacccag cagccgctgc      840

ctggcctgcc actggcttcc ccgccagggg tcccgcccgt ctccttgcac acccaggtcc      900

agagtgtggt cccccagcag ctactgacag tcacagctgc ccccacggca gcccctgtaa      960

cgaccactgt gacctcgcag atccagcagg tcccggtcct gctgcagccc cacttcatca     1020

aggcagactc gctgcttctg acagccatga agacagacgg agccactgtg aaggcggcag     1080

gtctcagtcc cctggtctct ggcaccactg tgcagacagg gcctttgccg accctggtga     1140

gtggcggaac catcttggca acagtcccac tggtcgtaga tgcggagaag ctgcctatca     1200

accggctcgc agctggcagc aaggccccgg cctctgccca gagccgtgga gagaagcgca     1260

cagcccacaa cgccattgag aagcgctacc gctcctccat caatgacaaa atcattgagc     1320

tcaaggatct ggtggtgggc actgaggcaa agctgaataa atctgctgtc ttgcgcaagg     1380

ccatcgacta cattcgcttt ctgcaacaca gcaaccagaa actcaagcag gagaacctaa     1440

gtctgcgcac tgctgtccac aaaagcaaat ctctgaagga tctggtgtcg gcctgtggca     1500

gtggagggaa cacagacgtg ctcatggagg gcgtgaagac tgaggtggag gacacactga     1560

ccccaccccc ctcggatgct ggctcacctt tccagagcag ccccttgtcc cttggcagca     1620

ggggcagtgg cagcggtggc agtggcagtg actcggagcc tgacagccca gtctttgagg     1680

acagcaaggc aaagccagag cagcggccgt ctctgcacag ccggggcatg ctggaccgct     1740

cccgcctggc cctgtgcacg ctcgtcttcc tctgcctgtc ctgcaacccc ttggcctcct     1800

tgctgggggc ccgggggctt cccagcccct cagataccac cagcgtctac catagccctg     1860

ggcgcaacgt gctgggcacc gagagcagag atggccctgg ctgggcccag tggctgctgc     1920

ccccagtggt ctggctgctc aatgggctgt tggtgctcgt ctccttggtg cttctctttg     1980

tctacggtga gccagtcaca cggccccact caggccccgc cgtgtacttc tggaggcatc     2040

gcaagcaggc tgacctggac ctggcccggg gagactttgc ccaggctgcc cagcagctgt     2100

ggctggccct gcgggcactg ggccggcccc tgcccacctc ccacctggac ctggcttgta     2160

gcctcctctg gaacctcatc cgtcacctgc tgcagcgtct ctgggtgggc cgctggctgg     2220

caggccgggc agggggcctg cagcaggact gtgctctgcg agtggatgct agcgccagcg     2280

cccgagacgc agccctggtc taccataagc tgcaccagct gcacaccatg gggaagcaca     2340

caggcgggca cctcactgcc accaacctgg cgctgagtgc cctgaacctg gcagagtgtg     2400

caggggatgc cgtgtctgtg gcgacgctgg ccgagatcta tgtggcggct gcattgagag     2460

tgaagaccag tctcccacgg gccttgcatt ttctgacacg cttcttcctg agcagtgccc     2520

gccaggcctg cctggcacag agtggctcag tgcctcctgc catgcagtgg ctctgccacc     2580

ccgtgggcca ccgtttcttc gtggatgggg actggtccgt gctcagtacc ccatgggaga     2640

gcctgtacag cttggccggg aacccagtgg accccctggc ccaggtgact cagctattcc     2700

gggaacatct cttagagcga gcactgaact gtgtgaccca gcccaacccc agccctgggt     2760

cagctgatgg ggacaaggaa ttctcggatg ccctcgggta cctgcagctg ctgaacagct     2820

gttctgatgc tgcgggggct cctgcctaca gcttctccat cagttccagc atggccacca     2880

ccaccggcgt agacccggtg gccaagtggt gggcctctct gacagctgtg gtgatccact     2940

ggctgcggcg ggatgaggag gcggctgagc ggctgtgccc gctggtggag cacctgcccc     3000

gggtgctgca ggagtctgag agacccctgc ccagggcagc tctgcactcc ttcaaggctg     3060

cccgggccct gctgggctgt gccaaggcag agtctggtcc agccagcctg accatctgtg     3120

agaaggccag tgggtacctg caggacagcc tggctaccac accagccagc agctccattg     3180

acaaggccgt gcagctgttc ctgtgtgacc tgcttcttgt ggtgcgcacc agcctgtggc     3240

ggcagcagca gcccccggcc ccggccccag cagcccaggg caccagcagc aggccccagg     3300

cttccgccct tgagctgcgt ggcttccaac gggacctgag cagcctgagg cggctggcac     3360

agagcttccg gcccgccatg cggagggtgt tcctacatga ggccacggcc cggctgatgg     3420

cgggggccag ccccacacgg acacaccagc tcctcgaccg cagtctgagg cggcgggcag     3480

gccccggtgg caaaggaggc gcggtggcgg agctggagcc gcggcccacg cggcgggagc     3540

acgcggaggc cttgctgctg gcctcctgct acctgccccc cggcttcctg tcggcgcccg     3600

ggcagcgcgt gggcatgctg gctgaggcgg cgcgcacact cgagaagctt ggcgatcgcc     3660

ggctgctgca cgactgtcag cagatgctca tgcgcctggg cggtgggacc actgtcactt     3720

ccagctagac cccgtgtccc cggcctcagc acccctgtct ctagccactt tggtcccgtg     3780

cagcttctgt cctgcgtcga agctttgaag gccgaaggca gtgcaagaga ctctggcctc     3840

cacagttcga cctgcggctg ctgtgtgcct tcgcggtgga aggcccgagg ggcgcgatct     3900

tgaccctaag accggcggcc atgatggtgc tgacctctgg tggccgatcg gggcactgca     3960

ggggccgagc cattttgggg ggcccccctc cttgctctgc aggcacctta gtggcttttt     4020

tcctcctgtg tacagggaag agaggggtac atttccctgt gctgacggaa gccaacttgg     4080

ctttcccgga ctgcaagcag ggctctgccc cagaggcctc tctctccgtc gtgggagaga     4140

gacgtgtaca tagtgtaggt cagcgtgctt agcctcctga cctgaggctc ctgtgctact     4200

ttgccttttg caaactttat tttcatagat tgagaagttt tgtacagaga attaaaaatg     4260

aaattattta taatctgggt tttgtgtctt cagctgatgg atgtgctgac tagtgagagt     4320

gcttgggccc tcccccagca cctagggaaa ggcttcccct ccccctccgg ccacaaggta     4380

cacaactttt aacttagctc ttcccgatgt ttgtttgtta gtgggaggag tggggagggc     4440

tggctgtatg gcctccagcc tacctgttcc ccctgctccc agggcacatg gttgggctgt     4500

gtcaaccctt agggcctcca tggggtcagt tgtcccttct cacctcccag ctctgtcccc     4560

atcaggtccc tgggtggcac gggaggatgg actgacttcc aggacctgtt gtgtgacagg     4620

agctacagct tgggtctccc tgcaagaagt ctggcacgtc tcacctcccc catcccggcc     4680

cctggtcatc tcacagcaaa gaagcctcct ccctcccgac ctgccgccac actggagagg     4740

gggcacaggg gcgggggagg tttcctgttc tgtgaaaggc cgactccctg actccattca     4800

tgcccccccc cccagcccct cccttcattc ccattcccca acctaaagcc tggcccggct     4860

cccagctgaa tctggtcgga atccacgggc tgcagatttt ccaaaacaat cgttgtatct     4920

ttattgactt tttttttttt ttttttctga atgcaatgac tgttttttac tcttaaggaa     4980

aataaacatc ttttagaaac aaaaaaaaaa aa                                   5012


<210> 3
<211> 1147
<212> PRT
<213> Homo sapiens

<400> 3
Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Pro Pro Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro 
    50                  55                  60                  


Asp Thr Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro 
                85                  90                  95      


Leu Ser Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser 
            100                 105                 110         


Met Pro Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro 
        115                 120                 125             


Leu Ser Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu 
    130                 135                 140                 


Leu Pro Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr 
145                 150                 155                 160 


Pro Val Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser 
                165                 170                 175     


Pro Pro Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser 
            180                 185                 190         


Pro Pro Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val 
        195                 200                 205             


Val Pro Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro 
    210                 215                 220                 


Val Thr Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu 
225                 230                 235                 240 


Gln Pro His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys 
                245                 250                 255     


Thr Asp Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser 
            260                 265                 270         


Gly Thr Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly 
        275                 280                 285             


Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro 
    290                 295                 300                 


Ile Asn Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser 
305                 310                 315                 320 


Arg Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
                325                 330                 335     


Ser Ser Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly 
            340                 345                 350         


Thr Glu Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp 
        355                 360                 365             


Tyr Ile Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn 
    370                 375                 380                 


Leu Ser Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu 
385                 390                 395                 400 


Val Ser Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly 
                405                 410                 415     


Val Lys Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala 
            420                 425                 430         


Gly Ser Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe 
    450                 455                 460                 


Glu Asp Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg 
465                 470                 475                 480 


Gly Met Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu 
                485                 490                 495     


Cys Leu Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu 
            500                 505                 510         


Pro Ser Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn 
        515                 520                 525             


Val Leu Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu 
    530                 535                 540                 


Leu Pro Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser 
545                 550                 555                 560 


Leu Val Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser 
                565                 570                 575     


Gly Pro Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp 
            580                 585                 590         


Leu Ala Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala 
        595                 600                 605             


Leu Arg Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala 
    610                 615                 620                 


Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp 
625                 630                 635                 640 


Val Gly Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys 
                645                 650                 655     


Ala Leu Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val 
            660                 665                 670         


Tyr His Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly 
        675                 680                 685             


His Leu Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu 
    690                 695                 700                 


Cys Ala Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val 
705                 710                 715                 720 


Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe 
                725                 730                 735     


Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln 
            740                 745                 750         


Ser Gly Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly 
        755                 760                 765             


His Arg Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp 
    770                 775                 780                 


Glu Ser Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln 
785                 790                 795                 800 


Val Thr Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys 
                805                 810                 815     


Val Thr Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu 
            820                 825                 830         


Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp 
        835                 840                 845             


Ala Ala Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala 
    850                 855                 860                 


Thr Thr Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr 
865                 870                 875                 880 


Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg 
                885                 890                 895     


Leu Cys Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu 
            900                 905                 910         


Arg Pro Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala 
        915                 920                 925             


Leu Leu Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile 
    930                 935                 940                 


Cys Glu Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro 
945                 950                 955                 960 


Ala Ser Ser Ser Ile Asp Lys Ala Val Gln Leu Phe Leu Cys Asp Leu 
                965                 970                 975     


Leu Leu Val Val Arg Thr Ser Leu Trp Arg Gln Gln Gln Pro Pro Ala 
            980                 985                 990         


Pro Ala Pro Ala Ala Gln Gly Thr  Ser Ser Arg Pro Gln  Ala Ser Ala 
        995                 1000                 1005             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1010                 1015                 1020             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1025                 1030                 1035             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1040                 1045                 1050             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1055                 1060                 1065             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1070                 1075                 1080             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1085                 1090                 1095             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1100                 1105                 1110             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1115                 1120                 1125             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1130                 1135                 1140             


Val Thr  Ser Ser 
    1145         


<210> 4
<211> 4922
<212> DNA
<213> Homo sapiens

<400> 4
agcagagctg cggccggggg aacccagttt ccgaggaact tttcgccggc gccgggccgc       60

ctctgaggcc agggcaggac acgaacgcgc ggagcggcgg cggcgactga gagccggggc      120

cgcggcggcg ctccctagga agggccgtac gaggcggcgg gcccggcggg cctcccggag      180

gaggcggctg cgccatggac gagccaccct tcagcgaggc ggctttggag caggcgctgg      240

gcgagccgtg cgatctggac gcggcgctgc tgaccgacat cgaagacatg cttcagctta      300

tcaacaacca agacagtgac ttccctggcc tatttgaccc accctatgct gggagtgggg      360

cagggggcac agaccctgcc agccccgata ccagctcccc aggcagcttg tctccacctc      420

ctgccacatt gagctcctct cttgaagcct tcctgagcgg gccgcaggca gcgccctcac      480

ccctgtcccc tccccagcct gcacccactc cattgaagat gtacccgtcc atgcccgctt      540

tctcccctgg gcctggtatc aaggaagagt cagtgccact gagcatcctg cagaccccca      600

ccccacagcc cctgccaggg gccctcctgc cacagagctt cccagcccca gccccaccgc      660

agttcagctc cacccctgtg ttaggctacc ccagccctcc gggaggcttc tctacaggaa      720

gccctcccgg gaacacccag cagccgctgc ctggcctgcc actggcttcc ccgccagggg      780

tcccgcccgt ctccttgcac acccaggtcc agagtgtggt cccccagcag ctactgacag      840

tcacagctgc ccccacggca gcccctgtaa cgaccactgt gacctcgcag atccagcagg      900

tcccggtcct gctgcagccc cacttcatca aggcagactc gctgcttctg acagccatga      960

agacagacgg agccactgtg aaggcggcag gtctcagtcc cctggtctct ggcaccactg     1020

tgcagacagg gcctttgccg accctggtga gtggcggaac catcttggca acagtcccac     1080

tggtcgtaga tgcggagaag ctgcctatca accggctcgc agctggcagc aaggccccgg     1140

cctctgccca gagccgtgga gagaagcgca cagcccacaa cgccattgag aagcgctacc     1200

gctcctccat caatgacaaa atcattgagc tcaaggatct ggtggtgggc actgaggcaa     1260

agctgaataa atctgctgtc ttgcgcaagg ccatcgacta cattcgcttt ctgcaacaca     1320

gcaaccagaa actcaagcag gagaacctaa gtctgcgcac tgctgtccac aaaagcaaat     1380

ctctgaagga tctggtgtcg gcctgtggca gtggagggaa cacagacgtg ctcatggagg     1440

gcgtgaagac tgaggtggag gacacactga ccccaccccc ctcggatgct ggctcacctt     1500

tccagagcag ccccttgtcc cttggcagca ggggcagtgg cagcggtggc agtggcagtg     1560

actcggagcc tgacagccca gtctttgagg acagcaaggc aaagccagag cagcggccgt     1620

ctctgcacag ccggggcatg ctggaccgct cccgcctggc cctgtgcacg ctcgtcttcc     1680

tctgcctgtc ctgcaacccc ttggcctcct tgctgggggc ccgggggctt cccagcccct     1740

cagataccac cagcgtctac catagccctg ggcgcaacgt gctgggcacc gagagcagag     1800

atggccctgg ctgggcccag tggctgctgc ccccagtggt ctggctgctc aatgggctgt     1860

tggtgctcgt ctccttggtg cttctctttg tctacggtga gccagtcaca cggccccact     1920

caggccccgc cgtgtacttc tggaggcatc gcaagcaggc tgacctggac ctggcccggg     1980

gagactttgc ccaggctgcc cagcagctgt ggctggccct gcgggcactg ggccggcccc     2040

tgcccacctc ccacctggac ctggcttgta gcctcctctg gaacctcatc cgtcacctgc     2100

tgcagcgtct ctgggtgggc cgctggctgg caggccgggc agggggcctg cagcaggact     2160

gtgctctgcg agtggatgct agcgccagcg cccgagacgc agccctggtc taccataagc     2220

tgcaccagct gcacaccatg gggaagcaca caggcgggca cctcactgcc accaacctgg     2280

cgctgagtgc cctgaacctg gcagagtgtg caggggatgc cgtgtctgtg gcgacgctgg     2340

ccgagatcta tgtggcggct gcattgagag tgaagaccag tctcccacgg gccttgcatt     2400

ttctgacacg cttcttcctg agcagtgccc gccaggcctg cctggcacag agtggctcag     2460

tgcctcctgc catgcagtgg ctctgccacc ccgtgggcca ccgtttcttc gtggatgggg     2520

actggtccgt gctcagtacc ccatgggaga gcctgtacag cttggccggg aacccagtgg     2580

accccctggc ccaggtgact cagctattcc gggaacatct cttagagcga gcactgaact     2640

gtgtgaccca gcccaacccc agccctgggt cagctgatgg ggacaaggaa ttctcggatg     2700

ccctcgggta cctgcagctg ctgaacagct gttctgatgc tgcgggggct cctgcctaca     2760

gcttctccat cagttccagc atggccacca ccaccggcgt agacccggtg gccaagtggt     2820

gggcctctct gacagctgtg gtgatccact ggctgcggcg ggatgaggag gcggctgagc     2880

ggctgtgccc gctggtggag cacctgcccc gggtgctgca ggagtctgag agacccctgc     2940

ccagggcagc tctgcactcc ttcaaggctg cccgggccct gctgggctgt gccaaggcag     3000

agtctggtcc agccagcctg accatctgtg agaaggccag tgggtacctg caggacagcc     3060

tggctaccac accagccagc agctccattg acaaggccgt gcagctgttc ctgtgtgacc     3120

tgcttcttgt ggtgcgcacc agcctgtggc ggcagcagca gcccccggcc ccggccccag     3180

cagcccaggg caccagcagc aggccccagg cttccgccct tgagctgcgt ggcttccaac     3240

gggacctgag cagcctgagg cggctggcac agagcttccg gcccgccatg cggagggtgt     3300

tcctacatga ggccacggcc cggctgatgg cgggggccag ccccacacgg acacaccagc     3360

tcctcgaccg cagtctgagg cggcgggcag gccccggtgg caaaggaggc gcggtggcgg     3420

agctggagcc gcggcccacg cggcgggagc acgcggaggc cttgctgctg gcctcctgct     3480

acctgccccc cggcttcctg tcggcgcccg ggcagcgcgt gggcatgctg gctgaggcgg     3540

cgcgcacact cgagaagctt ggcgatcgcc ggctgctgca cgactgtcag cagatgctca     3600

tgcgcctggg cggtgggacc actgtcactt ccagctagac cccgtgtccc cggcctcagc     3660

acccctgtct ctagccactt tggtcccgtg cagcttctgt cctgcgtcga agctttgaag     3720

gccgaaggca gtgcaagaga ctctggcctc cacagttcga cctgcggctg ctgtgtgcct     3780

tcgcggtgga aggcccgagg ggcgcgatct tgaccctaag accggcggcc atgatggtgc     3840

tgacctctgg tggccgatcg gggcactgca ggggccgagc cattttgggg ggcccccctc     3900

cttgctctgc aggcacctta gtggcttttt tcctcctgtg tacagggaag agaggggtac     3960

atttccctgt gctgacggaa gccaacttgg ctttcccgga ctgcaagcag ggctctgccc     4020

cagaggcctc tctctccgtc gtgggagaga gacgtgtaca tagtgtaggt cagcgtgctt     4080

agcctcctga cctgaggctc ctgtgctact ttgccttttg caaactttat tttcatagat     4140

tgagaagttt tgtacagaga attaaaaatg aaattattta taatctgggt tttgtgtctt     4200

cagctgatgg atgtgctgac tagtgagagt gcttgggccc tcccccagca cctagggaaa     4260

ggcttcccct ccccctccgg ccacaaggta cacaactttt aacttagctc ttcccgatgt     4320

ttgtttgtta gtgggaggag tggggagggc tggctgtatg gcctccagcc tacctgttcc     4380

ccctgctccc agggcacatg gttgggctgt gtcaaccctt agggcctcca tggggtcagt     4440

tgtcccttct cacctcccag ctctgtcccc atcaggtccc tgggtggcac gggaggatgg     4500

actgacttcc aggacctgtt gtgtgacagg agctacagct tgggtctccc tgcaagaagt     4560

ctggcacgtc tcacctcccc catcccggcc cctggtcatc tcacagcaaa gaagcctcct     4620

ccctcccgac ctgccgccac actggagagg gggcacaggg gcgggggagg tttcctgttc     4680

tgtgaaaggc cgactccctg actccattca tgcccccccc cccagcccct cccttcattc     4740

ccattcccca acctaaagcc tggcccggct cccagctgaa tctggtcgga atccacgggc     4800

tgcagatttt ccaaaacaat cgttgtatct ttattgactt tttttttttt ttttttctga     4860

atgcaatgac tgttttttac tcttaaggaa aataaacatc ttttagaaac aaaaaaaaaa     4920

aa                                                                    4922


<210> 5
<211> 2169
<212> DNA
<213> Homo sapiens

<400> 5
ctcggtcttt aaaaggaaga aggggcttat cgttaagtcg cttgtgatct tttcagtttc       60

tccagctgct ggctttttgg acacccactc ccccgccagg aggcagttgc aagcgcggag      120

gctgcgagaa ataactgcct cttgaaactt gcagggcgaa gagcaggcgg cgagcgctgg      180

gccggggagg gaccacccga gctgcgacgg gctctggggc tgcggggcag ggctggcgcc      240

cggagcctga gctgcaggag gtgcgctcgc tttcctcaac aggtggcggc ggggcgcgcg      300

ccgggagacc ccccctaatg cgggaaaagc acgtgtccgc attttagaga aggcaaggcc      360

ggtgtgttta tctgcaagcc attatacttg cccacgaatc tttgagaaca ttataatgac      420

ctttgtgcct cttcttgcaa ggtgttttct cagctgttat ctcaagacat ggatataaaa      480

aactcaccat ctagccttaa ttctccttcc tcctacaact gcagtcaatc catcttaccc      540

ctggagcacg gctccatata cataccttcc tcctatgtag acagccacca tgaatatcca      600

gccatgacat tctatagccc tgctgtgatg aattacagca ttcccagcaa tgtcactaac      660

ttggaaggtg ggcctggtcg gcagaccaca agcccaaatg tgttgtggcc aacacctggg      720

cacctttctc ctttagtggt ccatcgccag ttatcacatc tgtatgcgga acctcaaaag      780

agtccctggt gtgaagcaag atcgctagaa cacaccttac ctgtaaacag agagacactg      840

aaaaggaagg ttagtgggaa ccgttgcgcc agccctgtta ctggtccagg ttcaaagagg      900

gatgctcact tctgcgctgt ctgcagcgat tacgcatcgg gatatcacta tggagtctgg      960

tcgtgtgaag gatgtaaggc cttttttaaa agaagcattc aaggacataa tgattatatt     1020

tgtccagcta caaatcagtg tacaatcgat aaaaaccggc gcaagagctg ccaggcctgc     1080

cgacttcgga agtgttacga agtgggaatg gtgaagtgtg gctcccggag agagagatgt     1140

gggtaccgcc ttgtgcggag acagagaagt gccgacgagc agctgcactg tgccggcaag     1200

gccaagagaa gtggcggcca cgcgccccga gtgcgggagc tgctgctgga cgccctgagc     1260

cccgagcagc tagtgctcac cctcctggag gctgagccgc cccatgtgct gatcagccgc     1320

cccagtgcgc ccttcaccga ggcctccatg atgatgtccc tgaccaagtt ggccgacaag     1380

gagttggtac acatgatcag ctgggccaag aagattcccg gctttgtgga gctcagcctg     1440

ttcgaccaag tgcggctctt ggagagctgt tggatggagg tgttaatgat ggggctgatg     1500

tggcgctcaa ttgaccaccc cggcaagctc atctttgctc cagatcttgt tctggacagg     1560

gatgagggga aatgcgtaga aggaattctg gaaatctttg acatgctcct ggcaactact     1620

tcaaggtttc gagagttaaa actccaacac aaagaatatc tctgtgtcaa ggccatgatc     1680

ctgctcaatt ccagtatgta ccctctggtc acagcgaccc aggatgctga cagcagccgg     1740

aagctggctc acttgctgaa cgccgtgacc gatgctttgg tttgggtgat tgccaagagc     1800

ggcatctcct cccagcagca atccatgcgc ctggctaacc tcctgatgct cctgtcccac     1860

gtcaggcatg cgagtaacaa gggcatggaa catctgctca acatgaagtg caaaaatgtg     1920

gtcccagtgt atgacctgct gctggagatg ctgaatgccc acgtgcttcg cgggtgcaag     1980

tcctccatca cggggtccga gtgcagcccg gcagaggaca gtaaaagcaa agagggctcc     2040

cagaacccac agtctcagtg acgcctggcc ctgaggtgaa ctggcccaca gaggtcacag     2100

gctgaagcgt gaactccagt gtgtcaggag cctgggcttc atctttctgc tgtgtggtcc     2160

ctcatttgg                                                             2169


<210> 6
<211> 530
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr 
1               5                   10                  15      


Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile 
            20                  25                  30          


Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe 
        35                  40                  45              


Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn 
    50                  55                  60                  


Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp 
65                  70                  75                  80  


Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser 
                85                  90                  95      


His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser 
            100                 105                 110         


Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val 
        115                 120                 125             


Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg 
    130                 135                 140                 


Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His 
145                 150                 155                 160 


Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser 
                165                 170                 175     


Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr 
            180                 185                 190         


Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys 
        195                 200                 205             


Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys 
    210                 215                 220                 


Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His 
225                 230                 235                 240 


Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg 
                245                 250                 255     


Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu 
            260                 265                 270         


Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro 
        275                 280                 285             


Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys 
    290                 295                 300                 


Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val 
305                 310                 315                 320 


Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met 
                325                 330                 335     


Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly 
            340                 345                 350         


Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys 
        355                 360                 365             


Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr 
    370                 375                 380                 


Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val 
385                 390                 395                 400 


Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala 
                405                 410                 415     


Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala 
            420                 425                 430         


Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser 
        435                 440                 445             


Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His 
    450                 455                 460                 


Val Arg His Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys 
465                 470                 475                 480 


Cys Lys Asn Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn 
                485                 490                 495     


Ala His Val Leu Arg Gly Cys Lys Ser Ser Ile Thr Gly Ser Glu Cys 
            500                 505                 510         


Ser Pro Ala Glu Asp Ser Lys Ser Lys Glu Gly Ser Gln Asn Pro Gln 
        515                 520                 525             


Ser Gln 
    530 


<210> 7
<211> 8481
<212> DNA
<213> Homo sapiens

<400> 7
gagagacggc agcggccccg gcctccctct ccgccgcgct tcagcctccc gctccgccgc       60

gctccagcct cgctctccgc cgcccgcacc gccgcccgcg ccctcaccag agcagccatg      120

gaggaggtgg tgattgccgg catgtccggg aagctgccag agtcggagaa cttgcaggag      180

ttctgggaca acctcatcgg cggtgtggac atggtcacgg acgatgaccg tcgctggaag      240

gcggggctct acggcctgcc ccggcggtcc ggcaagctga aggacctgtc taggtttgat      300

gcctccttct tcggagtcca ccccaagcag gcacacacga tggaccctca gctgcggctg      360

ctgctggaag tcacctatga agccatcgtg gacggaggca tcaacccaga ttcactccga      420

ggaacacaca ctggcgtctg ggtgggcgtg agcggctctg agacctcgga ggccctgagc      480

cgagaccccg agacactcgt gggctacagc atggtgggct gccagcgagc gatgatggcc      540

aaccggctct ccttcttctt cgacttcaga gggcccagca tcgcactgga cacagcctgc      600

tcctccagcc tgatggccct gcagaacgcc taccaggcca tccacagcgg gcagtgccct      660

gccgccatcg tggggggcat caatgtcctg ctgaagccca acacctccgt gcagttcttg      720

aggctgggga tgctcagccc cgagggcacc tgcaaggcct tcgacacagc ggggaatggg      780

tactgccgct cggagggtgt ggtggccgtc ctgctgacca agaagtccct ggcccggcgg      840

gtgtacgcca ccatcctgaa cgccggcacc aatacagatg gcttcaagga gcaaggcgtg      900

accttcccct caggggatat ccaggagcag ctcatccgct cgttgtacca gtcggccgga      960

gtggcccctg agtcatttga atacatcgaa gcccacggca caggcaccaa ggtgggcgac     1020

ccccaggagc tgaatggcat cacccgagcc ctgtgcgcca cccgccagga gccgctgctc     1080

atcggctcca ccaagtccaa catggggcac ccggagccag cctcggggct ggcagccctg     1140

gccaaggtgc tgctgtccct ggagcacggg ctctgggccc ccaacctgca cttccatagc     1200

cccaaccctg agatcccagc gctgttggat gggcggctgc aggtggtgga ccagcccctg     1260

cccgtccgtg gcggcaacgt gggcatcaac tcctttggct tcgggggctc caacgtgcac     1320

atcatcctga ggcccaacac gcagccgccc cccgcacccg ccccacatgc caccctgccc     1380

cgtctgctgc gggccagcgg acgcacccct gaggccgtgc agaagctgct ggagcagggc     1440

ctccggcaca gccaggacct ggctttcctg agcatgctga acgacatcgc ggctgtcccc     1500

gccaccgcca tgcccttccg tggctacgct gtgctgggtg gtgagcgcgg tggcccagag     1560

gtgcagcagg tgcccgctgg cgagcgcccg ctctggttca tctgctctgg gatgggcaca     1620

cagtggcgcg ggatggggct gagcctcatg cgcctggacc gcttccgaga ttccatccta     1680

cgctccgatg aggctgtgaa gccattcggc ctgaaggtgt cacagctgct gctgagcaca     1740

gacgagagca cctttgatga catcgtccat tcgtttgtga gcctgactgc catccagata     1800

ggcctcatag acctgctgag ctgcatgggg ctgaggccag atggcatcgt cggccactcc     1860

ctgggggagg tggcctgtgg ctacgccgac ggctgcctgt cccaggagga ggccgtcctc     1920

gctgcctact ggaggggaca gtgcatcaaa gaagcccatc tcccgccggg cgccatggca     1980

gccgtgggct tgtcctggga ggagtgtaaa cagcgctgcc ccccgggcgt ggtgcccgcc     2040

tgccacaact ccaaggacac agtcaccatc tcgggacctc aggccccggt gtttgagttc     2100

gtggagcagc tgaggaagga gggtgtgttt gccaaggagg tgcggaccgg cggtatggcc     2160

ttccactcct acttcatgga ggccatcgca cccccactgc tgcaggagct caagaaggtg     2220

atccgggagc cgaagccacg ttcagcccgc tggctcagca cctctatccc cgaggcccag     2280

tggcacagca gcctggcacg cacgtcctcc gccgagtaca atgtcaacaa cctggtgagc     2340

cctgtgctgt tccaggaggc cctgtggcac gtgcctgagc acgcggtggt gctggagatc     2400

gcgccccacg ccctgctgca ggctgtcctg aagcgtggcc tgaagccgag ctgcaccatc     2460

atccccctga tgaagaagga tcacagggac aacctggagt tcttcctggc cggcatcggc     2520

aggctgcacc tctcaggcat cgacgccaac cccaatgcct tgttcccacc tgtggagttc     2580

ccagctcccc gaggaactcc cctcatctcc ccactcatca agtgggacca cagcctggcc     2640

tgggacgtgc cggccgccga ggacttcccc aacggttcag gttccccctc agccgccatc     2700

tacaacatcg acaccagctc cgagtctcct gaccactacc tggtggacca caccctcgac     2760

ggtcgcgtcc tcttccccgc cactggctac ctgagcatag tgtggaagac gctggcccgc     2820

gccctgggcc tgggcgtcga gcagctgcct gtggtgtttg aggatgtggt gctgcaccag     2880

gccaccatcc tgcccaagac tgggacagtg tccctggagg tacggctcct ggaggcctcc     2940

cgtgccttcg aggtgtcaga gaacggcaac ctggtagtga gtgggaaggt gtaccagtgg     3000

gatgaccctg accccaggct cttcgaccac ccggaaagcc ccacccccaa ccccacggag     3060

cccctcttcc tggcccaggc tgaagtttac aaggagctgc gtctgcgtgg ctacgactac     3120

ggccctcatt tccagggcat cctggaggcc agcctggaag gtgactcggg gaggctgctg     3180

tggaaggata actgggtgag cttcatggac accatgctgc agatgtccat cctgggctcg     3240

gccaagcacg gcctgtacct gcccacccgt gtcaccgcca tccacatcga ccctgccacc     3300

cacaggcaga agctgtacac actgcaggac aaggcccaag tggctgacgt ggtggtgagc     3360

aggtggctga gggtcacagt ggccggaggc gtccacatct ccgggctcca cactgagtcg     3420

gccccgcggc ggcagcagga gcagcaggtg cccatcctgg agaagttttg cttcactccc     3480

cacacggagg aggggtgcct gtctgagcgc gctgccctgc aggaggagct gcaactgtgc     3540

aaggggctgg tgcaggcact gcagaccaag gtgacccagc aggggctgaa gatggtggtg     3600

cccggactgg atggggccca gatcccccgg gacccctcac agcaggaact gccccggctg     3660

ttgtcggctg cctgcaggct tcagctcaac gggaacctgc agctggagct ggcgcaggtg     3720

ctggcccagg agaggcccaa gctgccagag gaccctctgc tcagcggcct cctggactcc     3780

ccggcactca aggcctgcct ggacactgcc gtggagaaca tgcccagcct gaagatgaag     3840

gtggtggagg tgctggctgg ccacggtcac ctgtattccc gcatcccagg cctgctcagc     3900

ccccatcccc tgctgcagct gagctacacg gccaccgacc gccaccccca ggccctggag     3960

gctgcccagg ccgagctgca gcagcacgac gttgcccagg gccagtggga tcccgcagac     4020

cctgccccca gcgccctggg cagcgccgac ctcctggtgt gcaactgtgc tgtggctgcc     4080

ctcggggacc cggcctcagc tctcagcaac atggtggctg ccctgagaga agggggcttt     4140

ctgctcctgc acacactgct ccgggggcac cccctcgggg acatcgtggc cttcctcacc     4200

tccactgagc cgcagtatgg ccagggcatc ctgagccagg acgcgtggga gagcctcttc     4260

tccagggtgt cgctgcgcct ggtgggcctg aagaagtcct tctacggctc cacgctcttc     4320

ctgtgccgcc ggcccacccc gcaggacagc cccatcttcc tgccggtgga cgataccagc     4380

ttccgctggg tggagtctct gaagggcatc ctggctgacg aagactcttc ccggcctgtg     4440

tggctgaagg ccatcaactg tgccacctcg ggcgtggtgg gcttggtgaa ctgtctccgc     4500

cgagagcccg gcgggaaccg cctccggtgt gtgctgctct ccaacctcag cagcacctcc     4560

cacgtcccgg aggtggaccc gggctccgca gaactgcaga aggtgttgca gggagacctg     4620

gtgatgaacg tctaccgcga cggggcctgg ggggctttcc gccacttcct gctggaggag     4680

gacaagcctg aggagccgac ggcacatgcc tttgtgagca ccctcacccg gggggacctg     4740

tcctccatcc gctgggtctg ctcctcgctg cgccatgccc agcccacctg ccctggcgcc     4800

cagctctgca cggtctacta cgcctccctc aacttccgcg acatcatgct ggccactggc     4860

aagctgtccc ctgatgccat cccagggaag tggacctccc aggacagcct gctaggtatg     4920

gagttctcgg gccgagacgc cagcggcaag cgtgtgatgg gactggtgcc tgccaagggc     4980

ctggccacct ctgtcctgct gtcaccggac ttcctctggg atgtgccttc caactggacg     5040

ctggaggagg cggcctcggt gcctgtcgtc tacagcacgg cctactacgc gctggtggtg     5100

cgtgggcggg tgcgccccgg ggagacgctg ctcatccact cgggctcggg cggcgtgggc     5160

caggccgcca tcgccatcgc cctcagtctg ggctgccgcg tcttcaccac cgtggggtcg     5220

gctgagaagc gggcgtacct ccaggccagg ttcccccagc tcgacagcac cagcttcgcc     5280

aactcccggg acacatcctt cgagcagcat gtgctgtggc acacgggcgg gaagggcgtt     5340

gacctggtct tgaactcctt ggcggaagag aagctgcagg ccagcgtgag gtgcttggct     5400

acgcacggtc gcttcctgga aattggcaaa ttcgaccttt ctcagaacca cccgctcggc     5460

atggctatct tcctgaagaa cgtgacattc cacggggtcc tactggatgc gttcttcaac     5520

gagagcagtg ctgactggcg ggaggtgtgg gcgcttgtgc aggccggcat ccgggatggg     5580

gtggtacggc ccctcaagtg cacggtgttc catggggccc aggtggagga cgccttccgc     5640

tacatggccc aagggaagca cattggcaaa gtcgtcgtgc aggtgcttgc ggaggagccg     5700

gaggcagtgc tgaagggggc caaacccaag ctgatgtcgg ccatctccaa gaccttctgc     5760

ccggcccaca agagctacat catcgctggt ggtctgggtg gcttcggcct ggagttggcg     5820

cagtggctga tacagcgtgg ggtgcagaag ctcgtgttga cttctcgctc cgggatccgg     5880

acaggctacc aggccaagca ggtccgccgg tggaggcgcc agggcgtaca ggtgcaggtg     5940

tccaccagca acatcagctc actggagggg gcccggggcc tcattgccga ggcggcgcag     6000

cttgggcccg tgggcggcgt cttcaacctg gccgtggtct tgagagatgg cttgctggag     6060

aaccagaccc cagagttctt ccaggacgtc tgcaagccca agtacagcgg caccctgaac     6120

ctggacaggg tgacccgaga ggcgtgccct gagctggact actttgtggt cttctcctct     6180

gtgagctgcg ggcgtggcaa tgcgggacag agcaactacg gctttgccaa ttccgccatg     6240

gagcgtatct gtgagaaacg ccggcacgaa ggcctcccag gcctggccgt gcagtggggc     6300

gccatcggcg acgtgggcat tttggtggag acgatgagca ccaacgacac gatcgtcagt     6360

ggcacgctgc cccagcgcat ggcgtcctgc ctggaggtgc tggacctctt cctgaaccag     6420

ccccacatgg tcctgagcag ctttgtgctg gctgagaagg ctgcggccta tagggacagg     6480

gacagccagc gggacctggt ggaggccgtg gcacacatcc tgggcatccg cgacttggct     6540

gctgtcaacc tggacagctc actggcggac ctgggcctgg actcgctcat gagcgtggag     6600

gtgcgccaga cgctggagcg tgagctcaac ctggtgctgt ccgtgcgcga ggtgcggcaa     6660

ctcacgctcc ggaaactgca ggagctgtcc tcaaaggcgg atgaggccag cgagctggca     6720

tgccccacgc ccaaggagga tggtctggcc cagcagcaga ctcagctgaa cctgcgctcc     6780

ctgctggtga acccggaggg ccccaccctg atgcggctca actccgtgca gagctcggag     6840

cggcccctgt tcctggtgca cccaatcgag ggctccacca ccgtgttcca cagcctggcc     6900

tcccggctca gcatccccac ctatggcctg cagtgcaccc gagctgcgcc ccttgacagc     6960

atccacagcc tggctgccta ctacatcgac tgcatcaggc aggtgcagcc cgagggcccc     7020

taccgcgtgg ccggctactc ctacggggcc tgcgtggcct ttgaaatgtg ctcccagctg     7080

caggcccagc agagcccagc ccccacccac aacagcctct tcctgttcga cggctcgccc     7140

acctacgtac tggcctacac ccagagctac cgggcaaagc tgaccccagg ctgtgaggct     7200

gaggctgaga cggaggccat atgcttcttc gtgcagcagt tcacggacat ggagcacaac     7260

agggtgctgg aggcgctgct gccgctgaag ggcctagagg agcgtgtggc agccgccgtg     7320

gacctgatca tcaagagcca ccagggcctg gaccgccagg agctgagctt tgcggcccgg     7380

tccttctact acaagctgcg tgccgctgag cagtacacac ccaaggccaa gtaccatggc     7440

aacgtgatgc tactgcgcgc caagacgggt ggcgcctacg gcgaggacct gggcgcggac     7500

tacaacctct cccaggtatg cgacgggaaa gtatccgtcc acgtcatcga gggtgaccac     7560

cgcacgctgc tggagggcag cggcctggag tccatcatca gcatcatcca cagctccctg     7620

gctgagccac gcgtgagcgt gcgggagggc taggcccgtg cccccgcctg ccaccggagg     7680

tcactccacc atccccaccc caccccaccc cacccccgcc atgcaacggg attgaagggt     7740

cctgccggtg ggaccctgtc cggcccagtg ccactgcccc ccgaggctgc tagatgtagg     7800

tgttaggcat gtcccaccca cccgccgcct cccacggcac ctcggggaca ccagagctgc     7860

cgacttggag actcctggtc tgtgaagagc cggtggtgcc cgtgcccgca ggaactgggc     7920

tgggcctcgt gcgcccgtgg ggtctgcgct tggtctttct gtgcttggat ttgcatattt     7980

attgcattgc tggtagagac ccccaggcct gtccaccctg ccaagactcc tcaggcagcg     8040

tgtgggtccc gcactctgcc cccatttccc cgatgtcccc tgcgggcgcg ggcagccacc     8100

caagcctgct ggctgcggcc ccctctcggc caggcattgg ctcagcccgc tgagtggggg     8160

gtcgtgggcc agtccccgag gagctgggcc cctgcacagg cacacagggc ccggccacac     8220

ccagcggccc cccgcacagc cacccgtggg gtgctgccct tatgcccggc gccgggcacc     8280

aactccatgt ttggtgtttg tctgtgtttg tttttcaaga aatgattcaa attgctgctt     8340

ggattttgaa atttactgta actgtcagtg tacacgtctg gaccccgttt catttttaca     8400

ccaatttggt aaaaatgctg ctctcagcct cccacaatta aaccgcatgt gatctccaaa     8460

aaaaaaaaaa aaaaaaaaaa a                                               8481


<210> 8
<211> 2511
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser 
1               5                   10                  15      


Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met 
            20                  25                  30          


Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro 
        35                  40                  45              


Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe 
    50                  55                  60                  


Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg 
65                  70                  75                  80  


Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn 
                85                  90                  95      


Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser 
            100                 105                 110         


Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val 
        115                 120                 125             


Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu 
    130                 135                 140                 


Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His 
                165                 170                 175     


Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu 
            180                 185                 190         


Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro 
        195                 200                 205             


Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg 
    210                 215                 220                 


Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg 
225                 230                 235                 240 


Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe 
                245                 250                 255     


Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu 
            260                 265                 270         


Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu 
        275                 280                 285             


Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu 
    290                 295                 300                 


Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu 
305                 310                 315                 320 


Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser 
                325                 330                 335     


Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu 
            340                 345                 350         


Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala 
        355                 360                 365             


Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg 
    370                 375                 380                 


Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val 
385                 390                 395                 400 


His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro 
                405                 410                 415     


His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu 
            420                 425                 430         


Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu 
        435                 440                 445             


Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala 
    450                 455                 460                 


Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro 
465                 470                 475                 480 


Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys 
                485                 490                 495     


Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg 
            500                 505                 510         


Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys 
        515                 520                 525             


Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser 
    530                 535                 540                 


Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln 
545                 550                 555                 560 


Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly 
                565                 570                 575     


Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly 
            580                 585                 590         


Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln 
        595                 600                 605             


Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly 
    610                 615                 620                 


Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro 
625                 630                 635                 640 


Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala 
                645                 650                 655     


Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala 
            660                 665                 670         


Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu 
        675                 680                 685             


Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu 
    690                 695                 700                 


Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala 
705                 710                 715                 720 


Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val 
                725                 730                 735     


Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val 
            740                 745                 750         


Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln 
        755                 760                 765             


Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu 
    770                 775                 780                 


Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile 
785                 790                 795                 800 


Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe 
                805                 810                 815     


Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro 
            820                 825                 830         


Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu 
        835                 840                 845             


Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile 
    850                 855                 860                 


Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu 
865                 870                 875                 880 


Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp 
                885                 890                 895     


Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val 
            900                 905                 910         


Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr 
        915                 920                 925             


Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe 
    930                 935                 940                 


Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln 
945                 950                 955                 960 


Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr 
                965                 970                 975     


Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys 
            980                 985                 990         


Glu Leu Arg Leu Arg Gly Tyr Asp  Tyr Gly Pro His Phe  Gln Gly Ile 
        995                 1000                 1005             


Leu Glu  Ala Ser Leu Glu Gly  Asp Ser Gly Arg Leu  Leu Trp Lys 
    1010                 1015                 1020             


Asp Asn  Trp Val Ser Phe Met  Asp Thr Met Leu Gln  Met Ser Ile 
    1025                 1030                 1035             


Leu Gly  Ser Ala Lys His Gly  Leu Tyr Leu Pro Thr  Arg Val Thr 
    1040                 1045                 1050             


Ala Ile  His Ile Asp Pro Ala  Thr His Arg Gln Lys  Leu Tyr Thr 
    1055                 1060                 1065             


Leu Gln  Asp Lys Ala Gln Val  Ala Asp Val Val Val  Ser Arg Trp 
    1070                 1075                 1080             


Leu Arg  Val Thr Val Ala Gly  Gly Val His Ile Ser  Gly Leu His 
    1085                 1090                 1095             


Thr Glu  Ser Ala Pro Arg Arg  Gln Gln Glu Gln Gln  Val Pro Ile 
    1100                 1105                 1110             


Leu Glu  Lys Phe Cys Phe Thr  Pro His Thr Glu Glu  Gly Cys Leu 
    1115                 1120                 1125             


Ser Glu  Arg Ala Ala Leu Gln  Glu Glu Leu Gln Leu  Cys Lys Gly 
    1130                 1135                 1140             


Leu Val  Gln Ala Leu Gln Thr  Lys Val Thr Gln Gln  Gly Leu Lys 
    1145                 1150                 1155             


Met Val  Val Pro Gly Leu Asp  Gly Ala Gln Ile Pro  Arg Asp Pro 
    1160                 1165                 1170             


Ser Gln  Gln Glu Leu Pro Arg  Leu Leu Ser Ala Ala  Cys Arg Leu 
    1175                 1180                 1185             


Gln Leu  Asn Gly Asn Leu Gln  Leu Glu Leu Ala Gln  Val Leu Ala 
    1190                 1195                 1200             


Gln Glu  Arg Pro Lys Leu Pro  Glu Asp Pro Leu Leu  Ser Gly Leu 
    1205                 1210                 1215             


Leu Asp  Ser Pro Ala Leu Lys  Ala Cys Leu Asp Thr  Ala Val Glu 
    1220                 1225                 1230             


Asn Met  Pro Ser Leu Lys Met  Lys Val Val Glu Val  Leu Ala Gly 
    1235                 1240                 1245             


His Gly  His Leu Tyr Ser Arg  Ile Pro Gly Leu Leu  Ser Pro His 
    1250                 1255                 1260             


Pro Leu  Leu Gln Leu Ser Tyr  Thr Ala Thr Asp Arg  His Pro Gln 
    1265                 1270                 1275             


Ala Leu  Glu Ala Ala Gln Ala  Glu Leu Gln Gln His  Asp Val Ala 
    1280                 1285                 1290             


Gln Gly  Gln Trp Asp Pro Ala  Asp Pro Ala Pro Ser  Ala Leu Gly 
    1295                 1300                 1305             


Ser Ala  Asp Leu Leu Val Cys  Asn Cys Ala Val Ala  Ala Leu Gly 
    1310                 1315                 1320             


Asp Pro  Ala Ser Ala Leu Ser  Asn Met Val Ala Ala  Leu Arg Glu 
    1325                 1330                 1335             


Gly Gly  Phe Leu Leu Leu His  Thr Leu Leu Arg Gly  His Pro Leu 
    1340                 1345                 1350             


Gly Asp  Ile Val Ala Phe Leu  Thr Ser Thr Glu Pro  Gln Tyr Gly 
    1355                 1360                 1365             


Gln Gly  Ile Leu Ser Gln Asp  Ala Trp Glu Ser Leu  Phe Ser Arg 
    1370                 1375                 1380             


Val Ser  Leu Arg Leu Val Gly  Leu Lys Lys Ser Phe  Tyr Gly Ser 
    1385                 1390                 1395             


Thr Leu  Phe Leu Cys Arg Arg  Pro Thr Pro Gln Asp  Ser Pro Ile 
    1400                 1405                 1410             


Phe Leu  Pro Val Asp Asp Thr  Ser Phe Arg Trp Val  Glu Ser Leu 
    1415                 1420                 1425             


Lys Gly  Ile Leu Ala Asp Glu  Asp Ser Ser Arg Pro  Val Trp Leu 
    1430                 1435                 1440             


Lys Ala  Ile Asn Cys Ala Thr  Ser Gly Val Val Gly  Leu Val Asn 
    1445                 1450                 1455             


Cys Leu  Arg Arg Glu Pro Gly  Gly Asn Arg Leu Arg  Cys Val Leu 
    1460                 1465                 1470             


Leu Ser  Asn Leu Ser Ser Thr  Ser His Val Pro Glu  Val Asp Pro 
    1475                 1480                 1485             


Gly Ser  Ala Glu Leu Gln Lys  Val Leu Gln Gly Asp  Leu Val Met 
    1490                 1495                 1500             


Asn Val  Tyr Arg Asp Gly Ala  Trp Gly Ala Phe Arg  His Phe Leu 
    1505                 1510                 1515             


Leu Glu  Glu Asp Lys Pro Glu  Glu Pro Thr Ala His  Ala Phe Val 
    1520                 1525                 1530             


Ser Thr  Leu Thr Arg Gly Asp  Leu Ser Ser Ile Arg  Trp Val Cys 
    1535                 1540                 1545             


Ser Ser  Leu Arg His Ala Gln  Pro Thr Cys Pro Gly  Ala Gln Leu 
    1550                 1555                 1560             


Cys Thr  Val Tyr Tyr Ala Ser  Leu Asn Phe Arg Asp  Ile Met Leu 
    1565                 1570                 1575             


Ala Thr  Gly Lys Leu Ser Pro  Asp Ala Ile Pro Gly  Lys Trp Thr 
    1580                 1585                 1590             


Ser Gln  Asp Ser Leu Leu Gly  Met Glu Phe Ser Gly  Arg Asp Ala 
    1595                 1600                 1605             


Ser Gly  Lys Arg Val Met Gly  Leu Val Pro Ala Lys  Gly Leu Ala 
    1610                 1615                 1620             


Thr Ser  Val Leu Leu Ser Pro  Asp Phe Leu Trp Asp  Val Pro Ser 
    1625                 1630                 1635             


Asn Trp  Thr Leu Glu Glu Ala  Ala Ser Val Pro Val  Val Tyr Ser 
    1640                 1645                 1650             


Thr Ala  Tyr Tyr Ala Leu Val  Val Arg Gly Arg Val  Arg Pro Gly 
    1655                 1660                 1665             


Glu Thr  Leu Leu Ile His Ser  Gly Ser Gly Gly Val  Gly Gln Ala 
    1670                 1675                 1680             


Ala Ile  Ala Ile Ala Leu Ser  Leu Gly Cys Arg Val  Phe Thr Thr 
    1685                 1690                 1695             


Val Gly  Ser Ala Glu Lys Arg  Ala Tyr Leu Gln Ala  Arg Phe Pro 
    1700                 1705                 1710             


Gln Leu  Asp Ser Thr Ser Phe  Ala Asn Ser Arg Asp  Thr Ser Phe 
    1715                 1720                 1725             


Glu Gln  His Val Leu Trp His  Thr Gly Gly Lys Gly  Val Asp Leu 
    1730                 1735                 1740             


Val Leu  Asn Ser Leu Ala Glu  Glu Lys Leu Gln Ala  Ser Val Arg 
    1745                 1750                 1755             


Cys Leu  Ala Thr His Gly Arg  Phe Leu Glu Ile Gly  Lys Phe Asp 
    1760                 1765                 1770             


Leu Ser  Gln Asn His Pro Leu  Gly Met Ala Ile Phe  Leu Lys Asn 
    1775                 1780                 1785             


Val Thr  Phe His Gly Val Leu  Leu Asp Ala Phe Phe  Asn Glu Ser 
    1790                 1795                 1800             


Ser Ala  Asp Trp Arg Glu Val  Trp Ala Leu Val Gln  Ala Gly Ile 
    1805                 1810                 1815             


Arg Asp  Gly Val Val Arg Pro  Leu Lys Cys Thr Val  Phe His Gly 
    1820                 1825                 1830             


Ala Gln  Val Glu Asp Ala Phe  Arg Tyr Met Ala Gln  Gly Lys His 
    1835                 1840                 1845             


Ile Gly  Lys Val Val Val Gln  Val Leu Ala Glu Glu  Pro Glu Ala 
    1850                 1855                 1860             


Val Leu  Lys Gly Ala Lys Pro  Lys Leu Met Ser Ala  Ile Ser Lys 
    1865                 1870                 1875             


Thr Phe  Cys Pro Ala His Lys  Ser Tyr Ile Ile Ala  Gly Gly Leu 
    1880                 1885                 1890             


Gly Gly  Phe Gly Leu Glu Leu  Ala Gln Trp Leu Ile  Gln Arg Gly 
    1895                 1900                 1905             


Val Gln  Lys Leu Val Leu Thr  Ser Arg Ser Gly Ile  Arg Thr Gly 
    1910                 1915                 1920             


Tyr Gln  Ala Lys Gln Val Arg  Arg Trp Arg Arg Gln  Gly Val Gln 
    1925                 1930                 1935             


Val Gln  Val Ser Thr Ser Asn  Ile Ser Ser Leu Glu  Gly Ala Arg 
    1940                 1945                 1950             


Gly Leu  Ile Ala Glu Ala Ala  Gln Leu Gly Pro Val  Gly Gly Val 
    1955                 1960                 1965             


Phe Asn  Leu Ala Val Val Leu  Arg Asp Gly Leu Leu  Glu Asn Gln 
    1970                 1975                 1980             


Thr Pro  Glu Phe Phe Gln Asp  Val Cys Lys Pro Lys  Tyr Ser Gly 
    1985                 1990                 1995             


Thr Leu  Asn Leu Asp Arg Val  Thr Arg Glu Ala Cys  Pro Glu Leu 
    2000                 2005                 2010             


Asp Tyr  Phe Val Val Phe Ser  Ser Val Ser Cys Gly  Arg Gly Asn 
    2015                 2020                 2025             


Ala Gly  Gln Ser Asn Tyr Gly  Phe Ala Asn Ser Ala  Met Glu Arg 
    2030                 2035                 2040             


Ile Cys  Glu Lys Arg Arg His  Glu Gly Leu Pro Gly  Leu Ala Val 
    2045                 2050                 2055             


Gln Trp  Gly Ala Ile Gly Asp  Val Gly Ile Leu Val  Glu Thr Met 
    2060                 2065                 2070             


Ser Thr  Asn Asp Thr Ile Val  Ser Gly Thr Leu Pro  Gln Arg Met 
    2075                 2080                 2085             


Ala Ser  Cys Leu Glu Val Leu  Asp Leu Phe Leu Asn  Gln Pro His 
    2090                 2095                 2100             


Met Val  Leu Ser Ser Phe Val  Leu Ala Glu Lys Ala  Ala Ala Tyr 
    2105                 2110                 2115             


Arg Asp  Arg Asp Ser Gln Arg  Asp Leu Val Glu Ala  Val Ala His 
    2120                 2125                 2130             


Ile Leu  Gly Ile Arg Asp Leu  Ala Ala Val Asn Leu  Asp Ser Ser 
    2135                 2140                 2145             


Leu Ala  Asp Leu Gly Leu Asp  Ser Leu Met Ser Val  Glu Val Arg 
    2150                 2155                 2160             


Gln Thr  Leu Glu Arg Glu Leu  Asn Leu Val Leu Ser  Val Arg Glu 
    2165                 2170                 2175             


Val Arg  Gln Leu Thr Leu Arg  Lys Leu Gln Glu Leu  Ser Ser Lys 
    2180                 2185                 2190             


Ala Asp  Glu Ala Ser Glu Leu  Ala Cys Pro Thr Pro  Lys Glu Asp 
    2195                 2200                 2205             


Gly Leu  Ala Gln Gln Gln Thr  Gln Leu Asn Leu Arg  Ser Leu Leu 
    2210                 2215                 2220             


Val Asn  Pro Glu Gly Pro Thr  Leu Met Arg Leu Asn  Ser Val Gln 
    2225                 2230                 2235             


Ser Ser  Glu Arg Pro Leu Phe  Leu Val His Pro Ile  Glu Gly Ser 
    2240                 2245                 2250             


Thr Thr  Val Phe His Ser Leu  Ala Ser Arg Leu Ser  Ile Pro Thr 
    2255                 2260                 2265             


Tyr Gly  Leu Gln Cys Thr Arg  Ala Ala Pro Leu Asp  Ser Ile His 
    2270                 2275                 2280             


Ser Leu  Ala Ala Tyr Tyr Ile  Asp Cys Ile Arg Gln  Val Gln Pro 
    2285                 2290                 2295             


Glu Gly  Pro Tyr Arg Val Ala  Gly Tyr Ser Tyr Gly  Ala Cys Val 
    2300                 2305                 2310             


Ala Phe  Glu Met Cys Ser Gln  Leu Gln Ala Gln Gln  Ser Pro Ala 
    2315                 2320                 2325             


Pro Thr  His Asn Ser Leu Phe  Leu Phe Asp Gly Ser  Pro Thr Tyr 
    2330                 2335                 2340             


Val Leu  Ala Tyr Thr Gln Ser  Tyr Arg Ala Lys Leu  Thr Pro Gly 
    2345                 2350                 2355             


Cys Glu  Ala Glu Ala Glu Thr  Glu Ala Ile Cys Phe  Phe Val Gln 
    2360                 2365                 2370             


Gln Phe  Thr Asp Met Glu His  Asn Arg Val Leu Glu  Ala Leu Leu 
    2375                 2380                 2385             


Pro Leu  Lys Gly Leu Glu Glu  Arg Val Ala Ala Ala  Val Asp Leu 
    2390                 2395                 2400             


Ile Ile  Lys Ser His Gln Gly  Leu Asp Arg Gln Glu  Leu Ser Phe 
    2405                 2410                 2415             


Ala Ala  Arg Ser Phe Tyr Tyr  Lys Leu Arg Ala Ala  Glu Gln Tyr 
    2420                 2425                 2430             


Thr Pro  Lys Ala Lys Tyr His  Gly Asn Val Met Leu  Leu Arg Ala 
    2435                 2440                 2445             


Lys Thr  Gly Gly Ala Tyr Gly  Glu Asp Leu Gly Ala  Asp Tyr Asn 
    2450                 2455                 2460             


Leu Ser  Gln Val Cys Asp Gly  Lys Val Ser Val His  Val Ile Glu 
    2465                 2470                 2475             


Gly Asp  His Arg Thr Leu Leu  Glu Gly Ser Gly Leu  Glu Ser Ile 
    2480                 2485                 2490             


Ile Ser  Ile Ile His Ser Ser  Leu Ala Glu Pro Arg  Val Ser Val 
    2495                 2500                 2505             


Arg Glu  Gly 
    2510     


<210> 9
<211> 5473
<212> DNA
<213> Homo sapiens

<400> 9
ggcaggacga ggtggcacca aattcccttc ggccaatgac gagccggagt ttacagaagc       60

ctcattagca tttccccaga ggcaggggca ggggcagagg ccgggtggtg tggtgtcggt      120

gtcggcagca tccccggcgc cctgctgcgg tcgccgcgag cctcggcctc tgtctcctcc      180

ccctcccgcc cttacctcca cgcgggaccg cccgcgccag tcaactcctc gcactttgcc      240

cctgcttggc agcggataaa agggggctga ggaaataccg gacacggtca cccgttgcca      300

gctctagcct ttaaattccc ggctcgggga cctccacgca ccgcggctag cgccgacaac      360

cagctagcgt gcaaggcgcc gcggctcagc gcgtaccggc gggcttcgaa accgcagtcc      420

tccggcgacc ccgaactccg ctccggagcc tcagccccct ggaaagtgat cccggcatcc      480

gagagccaag atgccggccc acttgctgca ggacgatatc tctagctcct ataccaccac      540

caccaccatt acagcgcctc cctccagggt cctgcagaat ggaggagata agttggagac      600

gatgcccctc tacttggaag acgacattcg ccctgatata aaagatgata tatatgaccc      660

cacctacaag gataaggaag gcccaagccc caaggttgaa tatgtctgga gaaacatcat      720

ccttatgtct ctgctacact tgggagccct gtatgggatc actttgattc ctacctgcaa      780

gttctacacc tggctttggg gggtattcta ctattttgtc agtgccctgg gcataacagc      840

aggagctcat cgtctgtgga gccaccgctc ttacaaagct cggctgcccc tacggctctt      900

tctgatcatt gccaacacaa tggcattcca gaatgatgtc tatgaatggg ctcgtgacca      960

ccgtgcccac cacaagtttt cagaaacaca tgctgatcct cataattccc gacgtggctt     1020

tttcttctct cacgtgggtt ggctgcttgt gcgcaaacac ccagctgtca aagagaaggg     1080

gagtacgcta gacttgtctg acctagaagc tgagaaactg gtgatgttcc agaggaggta     1140

ctacaaacct ggcttgctga tgatgtgctt catcctgccc acgcttgtgc cctggtattt     1200

ctggggtgaa acttttcaaa acagtgtgtt cgttgccact ttcttgcgat atgctgtggt     1260

gcttaatgcc acctggctgg tgaacagtgc tgcccacctc ttcggatatc gtccttatga     1320

caagaacatt agcccccggg agaatatcct ggtttcactt ggagctgtgg gtgagggctt     1380

ccacaactac caccactcct ttccctatga ctactctgcc agtgagtacc gctggcacat     1440

caacttcacc acattcttca ttgattgcat ggccgccctc ggtctggcct atgaccggaa     1500

gaaagtctcc aaggccgcca tcttggccag gattaaaaga accggagatg gaaactacaa     1560

gagtggctga gtttggggtc cctcaggttc ctttttcaaa aaccagccag gcagaggttt     1620

taatgtctgt ttattaacta ctgaataatg ctaccaggat gctaaagatg atgatgttaa     1680

cccattccag tacagtattc ttttaaaatt caaaagtatt gaaagccaac aactctgcct     1740

ttatgatgct aagctgatat tatttcttct cttatcctct ctctcttcta ggcccattgt     1800

cctccttttc actttattgc tatcgccctc ctttccctta ttgcctccca ggcaagcagc     1860

tggtcagtct ttgctcagtg tccagcttcc aaagcctaga caacctttct gtagcctaaa     1920

acgaatggtc tttgctccag ataactctct ttccttgagc tgttgtgagc tttgaagtag     1980

gtggcttgag ctagagataa aacagaatct tctgggtagt cccctgttga ttatcttcag     2040

cccaggcttt tgctagatgg aatggaaaag caacttcatt tgacacaaag cttctaaagc     2100

aggtaaattg tcgggggaga gagttagcat gtatgaatgt aaggatgagg gaagcgaagc     2160

aagaggaacc tctcgccatg atcagacata cagctgccta cctaatgagg acttcaagcc     2220

ccaccacata gcatgcttcc tttctctcct ggctcggggt aaaaagtggc tgcggtgttt     2280

ggcaatgcta attcaatgcc gcaacatata gttgaggccg aggataaaga aaagacattt     2340

taagtttgta gtaaaagtgg tctctgctgg ggaagggttt tcttttcttt ttttctttaa     2400

taacaaggag atttcttagt tcatatatca agaagtcttg aagttgggtg tttccagaat     2460

tggtaaaaac agcagctcat agaattttga gtattccatg agctgctcat tacagttctt     2520

tcctctttct gctctgccat cttcaggata ttggttcttc ccctcatagt aataagatgg     2580

ctgtggcatt tccaaacatc caaaaaaagg gaaggattta aggaggtgaa gtcgggtcaa     2640

aaataaaata tatatacata tatacattgc ttagaacgtt aaactattag agtatttccc     2700

ttccaaagag ggatgtttgg aaaaaactct gaaggagagg aggaattagt tgggatgcca     2760

atttcctctc cactgctgga catgagatgg agaggctgag ggacaggatc tataggcagc     2820

ttctaagagc gaacttcaca taggaaggga tctgagaaca cgttgccagg ggcttgagaa     2880

ggttactgag tgagttattg ggagtcttaa taaaataaac tagatattag gtccattcat     2940

taattagttc cagtttctcc ttgaaatgag taaaaactag aaggcttctc tccacagtgt     3000

tgtgcccctt cactcatttt tttttgagga gaagggggtc tctgttaaca tctagcctaa     3060

agtatacaac tgcctggggg gcagggttag gaatctcttc actaccctga ttcttgattc     3120

ctggctctac cctgtctgtc ccttttcttt gaccagatct ttctcttccc tgaacgtttt     3180

cttctttccc tggacaggca gcctcctttg tgtgtattca gaggcagtga tgacttgctg     3240

tccaggcagc tccctcctgc acacagaatg ctcagggtca ctgaaccact gcttctcttt     3300

tgaaagtaga gctagctgcc actttcacgt ggcctccgca gtgtctccac ctacacccct     3360

gtgctcccct gccacactga tggctcaaga caaggctggc aaaccctccc agaaacatct     3420

ctggcccaga aagcctctct ctccctccct ctctcatgag gcacagccaa gccaagcgct     3480

catgttgagc cagtgggcca gccacagagc aaaagagggt ttattttcag tcccctctct     3540

ctgggtcaga accagagggc atgctgaatg ccccctgctt acttggtgag ggtgccccgc     3600

ctgagtcagt gctctcagct ggcagtgcaa tgcttgtaga agtaggagga aacagttctc     3660

actgggaaga agcaagggca agaacccaag tgcctcacct cgaaaggagg ccctgttccc     3720

tggagtcagg gtgaactgca aagctttggc tgagacctgg gatttgagat accacaaacc     3780

ctgctgaaca cagtgtctgt tcagcaaact aaccagcatt ccctacagcc tagggcagac     3840

aatagtatag aagtctggaa aaaaacaaaa acagaatttg agaaccttgg accactcctg     3900

tccctgtagc tcagtcatca aagcagaagt ctggctttgc tctattaaga ttggaaatgt     3960

acactaccaa acactcagtc cactgttgag ccccagtgct ggaagggagg aaggcctttc     4020

ttctgtgtta attgcgtaga ggctacaggg gttagcctgg actaaaggca tccttgtctt     4080

ttgagctatt cacctcagta gaaaaggatc taagggaaga tcactgtagt ttagttctgt     4140

tgacctgtgc acctacccct tggaaatgtc tgctggtatt tctaattcca caggtcatca     4200

gatgcctgct tgataatata taaacaataa aaacaacttt cacttcttcc tattgtaatc     4260

gtgtgccatg gatctgatct gtaccatgac cctacataag gctggatggc acctcaggct     4320

gagggcccca atgtatgtgt ggctgtgggt gtgggtggga gtgtgtctgc tgagtaagga     4380

acacgatttt caagattcta aagctcaatt caagtgacac attaatgata aactcagatc     4440

tgatcaagag tccggatttc taacagtcct tgctttgggg ggtgtgctga caacttagct     4500

caggtgcctt acatcttttc taatcacagt gttgcatatg agcctgccct cactccctct     4560

gcagaatccc tttgcacctg agaccctact gaagtggctg gtagaaaaag gggcctgagt     4620

ggaggattat cagtatcacg atttgcagga ttcccttctg ggcttcattc tggaaacttt     4680

tgttagggct gcttttctta agtgcccaca tttgatggag ggtggaaata atttgaatgt     4740

atttgattta taagtttttt tttttttttt gggttaaaag atggttgtag catttaaaat     4800

ggaaaatttt ctccttggtt tgctagtatc ttgggtgtat tctctgtaag tgtagctcaa     4860

ataggtcatc atgaaaggtt aaaaaagcga ggtggccatg ttatgctggt ggttaaggcc     4920

agggcctctc caaccactgt gccactgact tgctgtgtga ccctgggcaa gtcacttaac     4980

tataaggtgc ctcagttttc cttctgttaa aatggggata ataatactga cctacctcaa     5040

agggcagttt tgaggcatga ctaatgcttt ttagaaagca ttttgggatc cttcagcaca     5100

ggaattctca agacctgagt attttttata ataggaatgt ccaccatgaa cttgatacgt     5160

ccgtgtgtcc cagatgctgt cattagtcta tatggttctc caagaaactg aatgaatcca     5220

ttggagaagc ggtggataac tagccagaca aaatttgaga atacataaac aacgcattgc     5280

cacggaaaca tacagaggat gccttttctg tgattgggtg ggattttttc cctttttatg     5340

tgggatatag tagttacttg tgacaagaat aattttggaa taatttctat taatatcaac     5400

tctgaagcta attgtactaa tctgagattg tgtttgttca taataaaagt gaagtgaatc     5460

tgattgcaaa aaa                                                        5473


<210> 10
<211> 359
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr 
1               5                   10                  15      


Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly 
            20                  25                  30          


Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro 
        35                  40                  45              


Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly 
    50                  55                  60                  


Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser 
65                  70                  75                  80  


Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys 
                85                  90                  95      


Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala 
            100                 105                 110         


Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr 
        115                 120                 125             


Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met 
    130                 135                 140                 


Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His 
145                 150                 155                 160 


His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly 
                165                 170                 175     


Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala 
            180                 185                 190         


Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu 
        195                 200                 205             


Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Met 
    210                 215                 220                 


Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu 
225                 230                 235                 240 


Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val 
                245                 250                 255     


Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly 
            260                 265                 270         


Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val 
        275                 280                 285             


Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe 
    290                 295                 300                 


Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr 
305                 310                 315                 320 


Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg 
                325                 330                 335     


Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly 
            340                 345                 350         


Asp Gly Asn Tyr Lys Ser Gly 
        355                 


<210> 11
<211> 4450
<212> DNA
<213> Homo sapiens

<400> 11
agccgatggg ggcggggaaa agtccggctg ggccgggaca aaagccggat cccgggaagc       60

taccggctgc tggggtgctc cggattttgc ggggttcgtc gggcctgtgg aagaagcgcc      120

gcgcacggac ttcggcagag gtagagcagg tctctctgca gccatgtcgg ccaaggcaat      180

ttcagagcag acgggcaaag aactccttta caagttcatc tgtaccacct cagccatcca      240

gaatcggttc aagtatgctc gggtcactcc tgacacagac tgggcccgct tgctgcagga      300

ccacccctgg ctgctcagcc agaacttggt agtcaagcca gaccagctga tcaaacgtcg      360

tggaaaactt ggtctcgttg gggtcaacct cactctggat ggggtcaagt cctggctgaa      420

gccacggctg ggacaggaag ccacagttgg caaggccaca ggcttcctca agaactttct      480

gatcgagccc ttcgtccccc acagtcaggc tgaggagttc tatgtctgca tctatgccac      540

ccgagaaggg gactacgtcc tgttccacca cgaggggggt gtggacgtgg gtgatgtgga      600

cgccaaggcc cagaagctgc ttgttggcgt ggatgagaaa ctgaatcctg aggacatcaa      660

aaaacacctg ttggtccacg cccctgaaga caagaaagaa attctggcca gttttatctc      720

cggcctcttc aatttctacg aggacttgta cttcacctac ctcgagatca atccccttgt      780

agtgaccaaa gatggagtct atgtccttga cttggcggcc aaggtggacg ccactgccga      840

ctacatctgc aaagtgaagt ggggtgacat cgagttccct ccccccttcg ggcgggaggc      900

atatccagag gaagcctaca ttgcagacct cgatgccaaa agtggggcaa gcctgaagct      960

gaccttgctg aaccccaaag ggaggatctg gaccatggtg gccgggggtg gcgcctctgt     1020

cgtgtacagc gataccatct gtgatctagg gggtgtcaac gagctggcaa actatgggga     1080

gtactcaggc gcccccagcg agcagcagac ctatgactat gccaagacta tcctctccct     1140

catgacccga gagaagcacc cagatggcaa gatcctcatc attggaggca gcatcgcaaa     1200

cttcaccaac gtggctgcca cgttcaaggg catcgtgaga gcaattcgag attaccaggg     1260

ccccctgaag gagcacgaag tcacaatctt tgtccgaaga ggtggcccca actatcagga     1320

gggcttacgg gtgatgggag aagtcgggaa gaccactggg atccccatcc atgtctttgg     1380

cacagagact cacatgacgg ccattgtggg catggccctg ggccaccggc ccatccccaa     1440

ccagccaccc acagcggccc acactgcaaa cttcctcctc aacgccagcg ggagcacatc     1500

gacgccagcc cccagcagga cagcatcttt ttctgagtcc agggccgatg aggtggcgcc     1560

tgcaaagaag gccaagcctg ccatgccaca agattcagtc ccaagtccaa gatccctgca     1620

aggaaagagc accaccctct tcagccgcca caccaaggcc attgtgtggg gcatgcagac     1680

ccgggccgtg caaggcatgc tggactttga ctatgtctgc tcccgagacg agccctcagt     1740

ggctgccatg gtctaccctt tcactgggga ccacaagcag aagttttact gggggcacaa     1800

agagatcctg atccctgtct tcaagaacat ggctgatgcc atgaggaagc atccggaggt     1860

agatgtgctc atcaactttg cctctctccg ctctgcctat gacagcacca tggagaccat     1920

gaactatgcc cagatccgga ccatcgccat catagctgaa ggcatccctg aggccctcac     1980

gagaaagctg atcaagaagg cggaccagaa gggagtgacc atcatcggac ctgccactgt     2040

tggaggcatc aagcctgggt gctttaagat tggcaacaca ggtgggatgc tggacaacat     2100

cctggcctcc aaactgtacc gcccaggcag cgtggcctat gtctcacgtt ccggaggcat     2160

gtccaacgag ctcaacaata tcatctctcg gaccacggat ggcgtctatg agggcgtggc     2220

cattggtggg gacaggtacc cgggctccac attcatggat catgtgttac gctatcagga     2280

cactccagga gtcaaaatga ttgtggttct tggagagatt gggggcactg aggaatataa     2340

gatttgccgg ggcatcaagg agggccgcct cactaagccc atcgtctgct ggtgcatcgg     2400

gacgtgtgcc accatgttct cctctgaggt ccagtttggc catgctggag cttgtgccaa     2460

ccaggcttct gaaactgcag tagccaagaa ccaggctttg aaggaagcag gagtgtttgt     2520

gccccggagc tttgatgagc ttggagagat catccagtct gtatacgaag atctcgtggc     2580

caatggagtc attgtacctg cccaggaggt gccgccccca accgtgccca tggactactc     2640

ctgggccagg gagcttggtt tgatccgcaa acctgcctcg ttcatgacca gcatctgcga     2700

tgagcgagga caggagctca tctacgcggg catgcccatc actgaggtct tcaaggaaga     2760

gatgggcatt ggcggggtcc tcggcctcct ctggttccag aaaaggttgc ctaagtactc     2820

ttgccagttc attgagatgt gtctgatggt gacagctgat cacgggccag ccgtctctgg     2880

agcccacaac accatcattt gtgcgcgagc tgggaaagac ctggtctcca gcctcacctc     2940

ggggctgctc accatcgggg atcggtttgg gggtgccttg gatgcagcag ccaagatgtt     3000

cagtaaagcc tttgacagtg gcattatccc catggagttt gtgaacaaga tgaagaagga     3060

agggaagctg atcatgggca ttggtcaccg agtgaagtcg ataaacaacc cagacatgcg     3120

agtgcagatc ctcaaagatt acgtcaggca gcacttccct gccactcctc tgctcgatta     3180

tgcactggaa gtagagaaga ttaccacctc gaagaagcca aatcttatcc tgaatgtaga     3240

tggtctcatc ggagtcgcat ttgtagacat gcttagaaac tgtgggtcct ttactcggga     3300

ggaagctgat gaatatattg acattggagc cctcaatggc atctttgtgc tgggaaggag     3360

tatggggttc attggacact atcttgatca gaagaggctg aagcaggggc tgtatcgtca     3420

tccgtgggat gatatttcat atgttcttcc ggaacacatg agcatgtaac agagccagga     3480

accctactgc agtaaactga agacaagatc tcttccccca agaaaaagtg tacagacagc     3540

tggcagtgga gcctgcttta tttagcaggg gcctggaatg taaacagcca ctggggtaca     3600

ggcaccgaag accaacatcc acaggctaac accccttcag tccacacaaa gaagcttcat     3660

atttttttta taagcataga aataaaaacc aagccaatat ttgtgacttt gctctgctac     3720

ctgctgtatt tattatatgg aagcatctaa gtactgtcag gatggggtct tcctcattgt     3780

agggcgttag gatgttgctt tctttttcca ttagttaaac atttttttct cctttggagg     3840

aagggaatga aacatttatg gcctcaagat actatacatt taaagcaccc caatgtctct     3900

cttttttttt ttttacttcc ctttcttctt ccttatataa catgaagaac attgtattaa     3960

tctgattttt aaagatcttt ttgtatgtta cgtgttaagg gcttgtttgg tatcccactg     4020

aaatgttctg tgttgcagac cagagtctgt ttatgtcagg gggatggggc cattgcatcc     4080

ttagccattg tcacaaaata tgtggagtag taacttaata tgtaaagttg taacatacat     4140

acatttaaaa tggaaatgca gaaagctgtg aaatgtcttg tgtcttatgt tctctgtatt     4200

tatgcagctg atttgtctgt ctgtaactga agtgtgggtc caaggactcc taactacttt     4260

gcatctgtaa tccacaaaga ttctgggcag ctgccacctc agtctcttct ctgtattatc     4320

atagtctggt ttaaataaac tatatagtaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa                                                            4450


<210> 12
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr 
1               5                   10                  15      


Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala 
            20                  25                  30          


Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro 
        35                  40                  45              


Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys 
    50                  55                  60                  


Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly 
65                  70                  75                  80  


Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly 
                85                  90                  95      


Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro 
            100                 105                 110         


His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu 
        115                 120                 125             


Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp 
    130                 135                 140                 


Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu 
145                 150                 155                 160 


Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Glu Asp 
                165                 170                 175     


Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr 
            180                 185                 190         


Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr 
        195                 200                 205             


Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr 
    210                 215                 220                 


Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro 
225                 230                 235                 240 


Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu 
                245                 250                 255     


Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys 
            260                 265                 270         


Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr 
        275                 280                 285             


Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr 
    290                 295                 300                 


Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala 
305                 310                 315                 320 


Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys 
                325                 330                 335     


Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala 
            340                 345                 350         


Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu 
        355                 360                 365             


Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr 
    370                 375                 380                 


Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile 
385                 390                 395                 400 


Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly 
                405                 410                 415     


Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala 
            420                 425                 430         


His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro 
        435                 440                 445             


Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val 
    450                 455                 460                 


Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro 
465                 470                 475                 480 


Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His 
                485                 490                 495     


Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met 
            500                 505                 510         


Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala 
        515                 520                 525             


Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly 
    530                 535                 540                 


His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met 
545                 550                 555                 560 


Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg 
                565                 570                 575     


Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg 
            580                 585                 590         


Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys 
        595                 600                 605             


Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala 
    610                 615                 620                 


Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly 
625                 630                 635                 640 


Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser 
                645                 650                 655     


Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn 
            660                 665                 670         


Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly 
        675                 680                 685             


Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr 
    690                 695                 700                 


Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly 
705                 710                 715                 720 


Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu 
                725                 730                 735     


Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe 
            740                 745                 750         


Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala 
        755                 760                 765             


Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val 
    770                 775                 780                 


Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val 
785                 790                 795                 800 


Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val 
                805                 810                 815     


Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly 
            820                 825                 830         


Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg 
        835                 840                 845             


Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys 
    850                 855                 860                 


Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys 
865                 870                 875                 880 


Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val 
                885                 890                 895     


Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile 
            900                 905                 910         


Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu 
        915                 920                 925             


Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys 
    930                 935                 940                 


Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val 
945                 950                 955                 960 


Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg 
                965                 970                 975     


Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp 
            980                 985                 990         


Tyr Val Arg Gln His Phe Pro Ala  Thr Pro Leu Leu Asp  Tyr Ala Leu 
        995                 1000                 1005             


Glu Val  Glu Lys Ile Thr Thr  Ser Lys Lys Pro Asn  Leu Ile Leu 
    1010                 1015                 1020             


Asn Val  Asp Gly Leu Ile Gly  Val Ala Phe Val Asp  Met Leu Arg 
    1025                 1030                 1035             


Asn Cys  Gly Ser Phe Thr Arg  Glu Glu Ala Asp Glu  Tyr Ile Asp 
    1040                 1045                 1050             


Ile Gly  Ala Leu Asn Gly Ile  Phe Val Leu Gly Arg  Ser Met Gly 
    1055                 1060                 1065             


Phe Ile  Gly His Tyr Leu Asp  Gln Lys Arg Leu Lys  Gln Gly Leu 
    1070                 1075                 1080             


Tyr Arg  His Pro Trp Asp Asp  Ile Ser Tyr Val Leu  Pro Glu His 
    1085                 1090                 1095             


Met Ser  Met 
    1100     


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
cggcgctgct gaccgacatc                                                   20


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gcgcagatcg cggagccat                                                    19


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
caagcttcta aagggcatcg                                                   20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cacagggaca acctggagtt                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
cgacgtggct ttttcttctc                                                   20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gcccatcccc aaccagccac                                                   20


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tcctgccagt aacagggaag                                                   20


<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ctctccgttc agattgaagg gg                                                22


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gagtcaacgg atttggtcgt                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
ccctgcccca ctcccagcat                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
ccctgcccca ctcccagcat                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
agtagggaga gaagccagcc                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
actccacagg tgggaacaag                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ccttctcttt gacagctggg                                                   20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ttgcaggcgc cacctcatcg                                                   20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
aggggaagtg tcagtacccg                                                   20


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
aatcccgcct ccatcctaac t                                                 21


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ttgaggtcaa tgaaggggtc                                                   20


