                         SEQUENCE LISTING

<110>  Boldog, Ferenc
       Heartlein, Mike
 
<120>  CELLS FOR PRODUCING RECOMBINANT IDURONATE-2-SULFATASE

<130>  2006685-0340

<150>  61/666,719
<151>  2012-06-29

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Glu Thr Gln Ala Asn Ser Thr Thr Asp Ala Leu Asn Val Leu Leu 
1               5                   10                  15      


Ile Ile Val Asp Asp Leu Arg Pro Ser Leu Gly Cys Tyr Gly Asp Lys 
            20                  25                  30          


Leu Val Arg Ser Pro Asn Ile Asp Gln Leu Ala Ser His Ser Leu Leu 
        35                  40                  45              


Phe Gln Asn Ala Phe Ala Gln Gln Ala Val Cys Ala Pro Ser Arg Val 
    50                  55                  60                  


Ser Phe Leu Thr Gly Arg Arg Pro Asp Thr Thr Arg Leu Tyr Asp Phe 
65                  70                  75                  80  


Asn Ser Tyr Trp Arg Val His Ala Gly Asn Phe Ser Thr Ile Pro Gln 
                85                  90                  95      


Tyr Phe Lys Glu Asn Gly Tyr Val Thr Met Ser Val Gly Lys Val Phe 
            100                 105                 110         


His Pro Gly Ile Ser Ser Asn His Thr Asp Asp Ser Pro Tyr Ser Trp 
        115                 120                 125             


Ser Phe Pro Pro Tyr His Pro Ser Ser Glu Lys Tyr Glu Asn Thr Lys 
    130                 135                 140                 


Thr Cys Arg Gly Pro Asp Gly Glu Leu His Ala Asn Leu Leu Cys Pro 
145                 150                 155                 160 


Val Asp Val Leu Asp Val Pro Glu Gly Thr Leu Pro Asp Lys Gln Ser 
                165                 170                 175     


Thr Glu Gln Ala Ile Gln Leu Leu Glu Lys Met Lys Thr Ser Ala Ser 
            180                 185                 190         


Pro Phe Phe Leu Ala Val Gly Tyr His Lys Pro His Ile Pro Phe Arg 
        195                 200                 205             


Tyr Pro Lys Glu Phe Gln Lys Leu Tyr Pro Leu Glu Asn Ile Thr Leu 
    210                 215                 220                 


Ala Pro Asp Pro Glu Val Pro Asp Gly Leu Pro Pro Val Ala Tyr Asn 
225                 230                 235                 240 


Pro Trp Met Asp Ile Arg Gln Arg Glu Asp Val Gln Ala Leu Asn Ile 
                245                 250                 255     


Ser Val Pro Tyr Gly Pro Ile Pro Val Asp Phe Gln Arg Lys Ile Arg 
            260                 265                 270         


Gln Ser Tyr Phe Ala Ser Val Ser Tyr Leu Asp Thr Gln Val Gly Arg 
        275                 280                 285             


Leu Leu Ser Ala Leu Asp Asp Leu Gln Leu Ala Asn Ser Thr Ile Ile 
    290                 295                 300                 


Ala Phe Thr Ser Asp His Gly Trp Ala Leu Gly Glu His Gly Glu Trp 
305                 310                 315                 320 


Ala Lys Tyr Ser Asn Phe Asp Val Ala Thr His Val Pro Leu Ile Phe 
                325                 330                 335     


Tyr Val Pro Gly Arg Thr Ala Ser Leu Pro Glu Ala Gly Glu Lys Leu 
            340                 345                 350         


Phe Pro Tyr Leu Asp Pro Phe Asp Ser Ala Ser Gln Leu Met Glu Pro 
        355                 360                 365             


Gly Arg Gln Ser Met Asp Leu Val Glu Leu Val Ser Leu Phe Pro Thr 
    370                 375                 380                 


Leu Ala Gly Leu Ala Gly Leu Gln Val Pro Pro Arg Cys Pro Val Pro 
385                 390                 395                 400 


Ser Phe His Val Glu Leu Cys Arg Glu Gly Lys Asn Leu Leu Lys His 
                405                 410                 415     


Phe Arg Phe Arg Asp Leu Glu Glu Asp Pro Tyr Leu Pro Gly Asn Pro 
            420                 425                 430         


Arg Glu Leu Ile Ala Tyr Ser Gln Tyr Pro Arg Pro Ser Asp Ile Pro 
        435                 440                 445             


Gln Trp Asn Ser Asp Lys Pro Ser Leu Lys Asp Ile Lys Ile Met Gly 
    450                 455                 460                 


Tyr Ser Ile Arg Thr Ile Asp Tyr Arg Tyr Thr Val Trp Val Gly Phe 
465                 470                 475                 480 


Asn Pro Asp Glu Phe Leu Ala Asn Phe Ser Asp Ile His Ala Gly Glu 
                485                 490                 495     


Leu Tyr Phe Val Asp Ser Asp Pro Leu Gln Asp His Asn Met Tyr Asn 
            500                 505                 510         


Asp Ser Gln Gly Gly Asp Leu Phe Gln Leu Leu Met Pro 
        515                 520                 525 


<210>  2
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  3
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Glu Asp Gln Ser Ser Thr Gly Phe Arg Leu Lys 
    290                 295                 300                 


Thr Ser Ser Thr Arg Lys Tyr Lys 
305                 310         


<210>  4
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Phe Leu Met Arg Thr Asn Thr 
            340             


<210>  5
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly Ser 
1               5                   10                  15      


Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser Ala 
            20                  25                  30          


Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val Pro 
        35                  40                  45              


Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala Gly 
    50                  55                  60                  


Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly Glu 
65                  70                  75                  80  


Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala Tyr 
                85                  90                  95      


Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly Tyr 
            100                 105                 110         


Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly Met 
        115                 120                 125             


Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala Ala 
    130                 135                 140                 


Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu Gly 
145                 150                 155                 160 


Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His Val 
                165                 170                 175     


Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg Leu 
            180                 185                 190         


Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His Asn 
        195                 200                 205             


Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His Tyr 
    210                 215                 220                 


Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu Asp 
225                 230                 235                 240 


Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly Tyr 
                245                 250                 255     


Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp Trp 
            260                 265                 270         


Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly Pro 
        275                 280                 285             


Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys His 
    290                 295                 300                 


Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn Thr 
305                 310                 315                 320 


Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp Arg 
                325                 330                 335     


Leu Pro Thr Met Asp 
            340     


<210>  6
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 
1               5                   10                  15      


Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 
            20                  25                  30          


Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 
        35                  40                  45              


Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser 
    50                  55                  60                  


Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val 
65                  70                  75                  80  


Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala 
                85                  90                  95      


Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly 
            100                 105                 110         


Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Phe Tyr Met Asp Ala 
        115                 120                 125             


Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly 
    130                 135                 140                 


Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly 
145                 150                 155                 160 


Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala 
                165                 170                 175     


Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 
            180                 185                 190         


Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His 
        195                 200                 205             


Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 
    210                 215                 220                 


Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His 
225                 230                 235                 240 


Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 
                245                 250                 255     


Tyr Ala Asn Ile Trp Gln Gly Glu Phe Pro Val Thr Asn Thr Gly Glu 
            260                 265                 270         


Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly 
        275                 280                 285             


Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 
    290                 295                 300                 


Trp Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly 
305                 310                 315                 320 


Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 
                325                 330                 335     


His Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn 
            340                 345                 350         


Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp 
        355                 360                 365             


Arg Leu Pro Thr Met Asp 
    370                 


<210>  7
<211>  1653
<212>  DNA
<213>  Homo sapiens

<400>  7
atgcccccgc cccgcaccgg ccgcggcctg ctgtggctgg gcctggtgct gagcagcgtg       60

tgcgtggccc tgggcagcga gacccaggcc aacagcacca ccgacgccct gaacgtgctg      120

ctgatcatcg tggacgacct gcgccccagc ctgggctgct acggcgacaa gctggtgcgc      180

agccccaaca tcgaccagct ggccagccac agcctgctgt tccagaacgc cttcgcccag      240

caggccgtgt gcgcccccag ccgcgtgagc ttcctgaccg gccgccgccc cgacaccacc      300

cgcctgtacg acttcaacag ctactggcgc gtgcacgccg gcaacttcag caccatcccc      360

cagtacttca aggagaacgg ctacgtgacc atgagcgtgg gcaaggtgtt ccaccccggc      420

atcagcagca accacaccga cgacagcccc tacagctgga gcttcccccc ctaccacccc      480

agcagcgaga agtacgagaa caccaagacc tgccgcggcc ccgacggcga gctgcacgcc      540

aacctgctgt gccccgtgga cgtgctggac gtgcccgagg gcaccctgcc cgacaagcag      600

agcaccgagc aggccatcca gctgctggag aagatgaaga ccagcgccag ccccttcttc      660

ctggccgtgg gctaccacaa gccccacatc cccttccgct accccaagga gttccagaag      720

ctgtaccccc tggagaacat caccctggcc cccgaccccg aggtgcccga cggcctgccc      780

cccgtggcct acaacccctg gatggacatc cgccagcgcg aggacgtgca ggccctgaac      840

atcagcgtgc cctacggccc catccccgtg gacttccagc gcaagatccg ccagagctac      900

ttcgccagcg tgagctacct ggacacccag gtgggccgcc tgctgagcgc cctggacgac      960

ctgcagctgg ccaacagcac catcatcgcc ttcaccagcg accacggctg ggccctgggc     1020

gagcacggcg agtgggccaa gtacagcaac ttcgacgtgg ccacccacgt gcccctgatc     1080

ttctacgtgc ccggccgcac cgccagcctg cccgaggccg gcgagaagct gttcccctac     1140

ctggacccct tcgacagcgc cagccagctg atggagcccg gccgccagag catggacctg     1200

gtggagctgg tgagcctgtt ccccaccctg gccggcctgg ccggcctgca ggtgcccccc     1260

cgctgccccg tgcccagctt ccacgtggag ctgtgccgcg agggcaagaa cctgctgaag     1320

cacttccgct tccgcgacct ggaggaggac ccctacctgc ccggcaaccc ccgcgagctg     1380

atcgcctaca gccagtaccc ccgccccagc gacatccccc agtggaacag cgacaagccc     1440

agcctgaagg acatcaagat catgggctac agcatccgca ccatcgacta ccgctacacc     1500

gtgtgggtgg gcttcaaccc cgacgagttc ctggccaact tcagcgacat ccacgccggc     1560

gagctgtact tcgtggacag cgaccccctg caggaccaca acatgtacaa cgacagccag     1620

ggcggcgacc tgttccagct gctgatgccc tag                                  1653


<210>  8
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  8
atggctgcgc ccgcactagg gctggtgtgt ggacgttgcc ctgagctggg tctcgtcctc       60

ttgctgctgc tgctctcgct gctgtgtgga gcggcaggga gccaggaggc cgggaccggt      120

gcgggcgcgg ggtcccttgc gggttcttgc ggctgcggca cgccccagcg gcctggcgcc      180

catggcagtt cggcagccgc tcaccgatac tcgcgggagg ctaacgctcc gggccccgta      240

cccggagagc ggcaactcgc gcactcaaag atggtcccca tccctgctgg agtatttaca      300

atgggcacag atgatcctca gataaagcag gatggggaag cacctgcgag gagagttact      360

attgatgcct tttacatgga tgcctatgaa gtcagtaata ctgaatttga gaagtttgtg      420

aactcaactg gctatttgac agaggctgag aagtttggcg actcctttgt ctttgaaggc      480

atgttgagtg agcaagtgaa gaccaatatt caacaggcag ttgcagctgc tccctggtgg      540

ttacctgtga aaggcgctaa ctggagacac ccagaagggc ctgactctac tattctgcac      600

aggccggatc atccagttct ccatgtgtcc tggaatgatg cggttgccta ctgcacttgg      660

gcagggaagc ggctgcccac ggaagctgag tgggaataca gctgtcgagg aggcctgcat      720

aatagacttt tcccctgggg caacaaactg cagcccaaag gccagcatta tgccaacatt      780

tggcagggcg agtttccggt gaccaacact ggtgaggatg gcttccaagg aactgcgcct      840

gttgatgcct tccctcccaa tggttatggc ttatacaaca tagtggggaa cgcatgggaa      900

tggacttcag actggtggac tgttcatcat tctgttgaag aaacgcttaa cccaaaaggt      960

cccccttctg ggaaagaccg agtgaagaaa ggtggatcct acatgtgcca taggtcttat     1020

tgttacaggt atcgctgtgc tgctcggagc cagaacacac ctgatagctc tgcttcgaat     1080

ctgggattcc gctgtgcagc cgaccgcctg cccaccatgg actga                     1125


