                         SEQUENCE LISTING

<110>  University of Rochester
       Perkins, Archibald S.
       Zhang, Yi
 
<120>  METHODS FOR TREATING MDS1-EVI1 MEDIATED CANCER

<130>  29556.3242 (6-2109)

<150>  US 61/666,223
<151>  2012-06-29

<150>  US 61/738,137
<151>  2012-12-17

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1239
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ser Lys Gly Arg Ala Arg Lys Leu Ala Thr Asn Asn Glu Cys 
1               5                   10                  15      


Val Tyr Gly Asn Tyr Pro Glu Ile Pro Leu Glu Glu Met Pro Asp Ala 
            20                  25                  30          


Asp Gly Val Ala Ser Thr Pro Ser Leu Asn Ile Gln Glu Pro Cys Ser 
        35                  40                  45              


Pro Ala Thr Ser Ser Glu Ala Phe Thr Pro Lys Glu Gly Ser Pro Tyr 
    50                  55                  60                  


Lys Ala Pro Ile Tyr Ile Pro Asp Asp Ile Pro Ile Pro Ala Glu Phe 
65                  70                  75                  80  


Glu Leu Arg Glu Ser Asn Met Pro Gly Ala Gly Leu Gly Ile Trp Thr 
                85                  90                  95      


Lys Arg Lys Ile Glu Val Gly Glu Lys Phe Gly Pro Tyr Val Gly Glu 
            100                 105                 110         


Gln Arg Ser Asn Leu Lys Asp Pro Ser Tyr Gly Trp Glu Ile Leu Asp 
        115                 120                 125             


Glu Phe Tyr Asn Val Lys Phe Cys Ile Asp Ala Ser Gln Pro Asp Val 
    130                 135                 140                 


Gly Ser Trp Leu Lys Tyr Ile Arg Phe Ala Gly Cys Tyr Asp Gln His 
145                 150                 155                 160 


Asn Leu Val Ala Cys Gln Ile Asn Asp Gln Ile Phe Tyr Arg Val Val 
                165                 170                 175     


Ala Asp Ile Ala Pro Gly Glu Glu Leu Leu Leu Phe Met Lys Ser Glu 
            180                 185                 190         


Asp Tyr Pro His Glu Thr Met Ala Pro Asp Ile His Glu Glu Arg Gln 
        195                 200                 205             


Tyr Arg Cys Glu Asp Cys Asp Gln Leu Phe Glu Ser Lys Ala Glu Leu 
    210                 215                 220                 


Ala Asp His Gln Lys Phe Pro Cys Ser Thr Pro His Ser Ala Phe Ser 
225                 230                 235                 240 


Met Val Glu Glu Asp Phe Gln Gln Lys Leu Glu Ser Glu Asn Asp Leu 
                245                 250                 255     


Gln Glu Ile His Thr Ile Gln Glu Cys Lys Glu Cys Asp Gln Val Phe 
            260                 265                 270         


Pro Asp Leu Gln Ser Leu Glu Lys His Met Leu Ser His Thr Glu Glu 
        275                 280                 285             


Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe Asn Trp Lys Ser 
    290                 295                 300                 


Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly Lys His Tyr Glu 
305                 310                 315                 320 


Cys Glu Asn Cys Ala Lys Val Phe Thr Asp Pro Ser Asn Leu Gln Arg 
                325                 330                 335     


His Ile Arg Ser Gln His Val Gly Ala Arg Ala His Ala Cys Pro Glu 
            340                 345                 350         


Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys Gln His Lys His 
        355                 360                 365             


Ile His Ser Ser Val Lys Pro Phe Ile Cys Glu Val Cys His Lys Ser 
    370                 375                 380                 


Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg Met His Ala Asp 
385                 390                 395                 400 


Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln Met Phe Ser Thr 
                405                 410                 415     


Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu Gly Lys Asn His 
            420                 425                 430         


Phe Ala Ala Gly Gly Phe Phe Gly Gln Gly Ile Ser Leu Pro Gly Thr 
        435                 440                 445             


Pro Ala Met Asp Lys Thr Ser Met Val Asn Met Ser His Ala Asn Pro 
    450                 455                 460                 


Gly Leu Ala Asp Tyr Phe Gly Ala Asn Arg His Pro Ala Gly Leu Thr 
465                 470                 475                 480 


Phe Pro Thr Ala Pro Gly Phe Ser Phe Ser Phe Pro Gly Leu Phe Pro 
                485                 490                 495     


Ser Gly Leu Tyr His Arg Pro Pro Leu Ile Pro Ala Ser Ser Pro Val 
            500                 505                 510         


Lys Gly Leu Ser Ser Thr Glu Gln Thr Asn Lys Ser Gln Ser Pro Leu 
        515                 520                 525             


Met Thr His Pro Gln Ile Leu Pro Ala Thr Gln Asp Ile Leu Lys Ala 
    530                 535                 540                 


Leu Ser Lys His Pro Ser Val Gly Asp Asn Lys Pro Val Glu Leu Gln 
545                 550                 555                 560 


Pro Glu Arg Ser Ser Glu Glu Arg Pro Phe Glu Lys Ile Ser Asp Gln 
                565                 570                 575     


Ser Glu Ser Ser Asp Leu Asp Asp Val Ser Thr Pro Ser Gly Ser Asp 
            580                 585                 590         


Leu Glu Thr Thr Ser Gly Ser Asp Leu Glu Ser Asp Ile Glu Ser Asp 
        595                 600                 605             


Lys Glu Lys Phe Lys Glu Asn Gly Lys Met Phe Lys Asp Lys Val Ser 
    610                 615                 620                 


Pro Leu Gln Asn Leu Ala Ser Ile Asn Asn Lys Lys Glu Tyr Ser Asn 
625                 630                 635                 640 


His Ser Ile Phe Ser Pro Ser Leu Glu Glu Gln Thr Ala Val Ser Gly 
                645                 650                 655     


Ala Val Asn Asp Ser Ile Lys Ala Ile Ala Ser Ile Ala Glu Lys Tyr 
            660                 665                 670         


Phe Gly Ser Thr Gly Leu Val Gly Leu Gln Asp Lys Lys Val Gly Ala 
        675                 680                 685             


Leu Pro Tyr Pro Ser Met Phe Pro Leu Pro Phe Phe Pro Ala Phe Ser 
    690                 695                 700                 


Gln Ser Met Tyr Pro Phe Pro Asp Arg Asp Leu Arg Ser Leu Pro Leu 
705                 710                 715                 720 


Lys Met Glu Pro Gln Ser Pro Gly Glu Val Lys Lys Leu Gln Lys Gly 
                725                 730                 735     


Ser Ser Glu Ser Pro Phe Asp Leu Thr Thr Lys Arg Lys Asp Glu Lys 
            740                 745                 750         


Pro Leu Thr Pro Val Pro Ser Lys Pro Pro Val Thr Pro Ala Thr Ser 
        755                 760                 765             


Gln Asp Gln Pro Leu Asp Leu Ser Met Gly Ser Arg Ser Arg Ala Ser 
    770                 775                 780                 


Gly Thr Lys Leu Thr Glu Pro Arg Lys Asn His Val Phe Gly Gly Lys 
785                 790                 795                 800 


Lys Gly Ser Asn Val Glu Ser Arg Pro Ala Ser Asp Gly Ser Leu Gln 
                805                 810                 815     


His Ala Arg Pro Thr Pro Phe Phe Met Asp Pro Ile Tyr Arg Val Glu 
            820                 825                 830         


Lys Arg Lys Leu Thr Asp Pro Leu Glu Ala Leu Lys Glu Lys Tyr Leu 
        835                 840                 845             


Arg Pro Ser Pro Gly Phe Leu Phe His Pro Gln Phe Gln Leu Pro Asp 
    850                 855                 860                 


Gln Arg Thr Trp Met Ser Ala Ile Glu Asn Met Ala Glu Lys Leu Glu 
865                 870                 875                 880 


Ser Phe Ser Ala Leu Lys Pro Glu Ala Ser Glu Leu Leu Gln Ser Val 
                885                 890                 895     


Pro Ser Met Phe Asn Phe Arg Ala Pro Pro Asn Ala Leu Pro Glu Asn 
            900                 905                 910         


Leu Leu Arg Lys Gly Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys 
        915                 920                 925             


Ile Phe Pro Arg Ser Ala Asn Leu Thr Arg His Leu Arg Thr His Thr 
    930                 935                 940                 


Gly Glu Gln Pro Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile 
945                 950                 955                 960 


Ser Ser Asn Leu Gln Arg His Val Arg Asn Ile His Asn Lys Glu Lys 
                965                 970                 975     


Pro Phe Lys Cys His Leu Cys Asp Arg Cys Phe Gly Gln Gln Thr Asn 
            980                 985                 990         


Leu Asp Arg His Leu Lys Lys His  Glu Asn Gly Asn Met  Ser Gly Thr 
        995                 1000                 1005             


Ala Thr  Ser Ser Pro His Ser  Glu Leu Glu Ser Thr  Gly Ala Ile 
    1010                 1015                 1020             


Leu Asp  Asp Lys Glu Asp Ala  Tyr Phe Thr Glu Ile  Arg Asn Phe 
    1025                 1030                 1035             


Ile Gly  Asn Ser Asn His Gly  Ser Gln Ser Pro Arg  Asn Val Glu 
    1040                 1045                 1050             


Glu Arg  Met Asn Gly Ser His  Phe Lys Asp Glu Lys  Ala Leu Val 
    1055                 1060                 1065             


Thr Ser  Gln Asn Ser Asp Leu  Leu Asp Asp Glu Glu  Val Glu Asp 
    1070                 1075                 1080             


Glu Val  Leu Leu Asp Glu Glu  Asp Glu Asp Asn Asp  Ile Thr Gly 
    1085                 1090                 1095             


Lys Thr  Gly Lys Glu Pro Val  Thr Ser Asn Leu His  Glu Gly Asn 
    1100                 1105                 1110             


Pro Glu  Asp Asp Tyr Glu Glu  Thr Ser Ala Leu Glu  Met Ser Cys 
    1115                 1120                 1125             


Lys Thr  Ser Pro Val Arg Tyr  Lys Glu Glu Glu Tyr  Lys Ser Gly 
    1130                 1135                 1140             


Leu Ser  Ala Leu Asp His Ile  Arg His Phe Thr Asp  Ser Leu Lys 
    1145                 1150                 1155             


Met Arg  Lys Met Glu Asp Asn  Gln Tyr Ser Glu Ala  Glu Leu Ser 
    1160                 1165                 1170             


Ser Phe  Ser Thr Ser His Val  Pro Glu Glu Leu Lys  Gln Pro Leu 
    1175                 1180                 1185             


His Arg  Lys Ser Lys Ser Gln  Ala Tyr Ala Met Met  Leu Ser Leu 
    1190                 1195                 1200             


Ser Asp  Lys Glu Ser Leu His  Ser Thr Ser His Ser  Ser Ser Asn 
    1205                 1210                 1215             


Val Trp  His Ser Met Ala Arg  Ala Ala Ala Glu Ser  Ser Ala Ile 
    1220                 1225                 1230             


Gln Ser  Ile Ser His Val 
    1235                 


<210>  2
<211>  3720
<212>  DNA
<213>  Homo sapiens

<400>  2
atgagatcca aaggcagggc aaggaaactg gccacaaata atgagtgtgt atatggcaac       60

taccctgaaa tacctttgga agaaatgcca gatgcagatg gagtagccag cactccctcc      120

ctcaatattc aagagccatg ctctcctgcc acatccagtg aagcattcac tccaaaggag      180

ggttctcctt acaaagcccc catctacatc cctgatgata tccccattcc tgctgagttt      240

gaacttcgag agtcaaatat gcctggggca ggactaggaa tatggaccaa aaggaagatc      300

gaagtaggtg aaaagtttgg gccttatgtg ggagagcaga ggtcaaacct gaaagacccc      360

agttatggat gggagatctt agacgaattt tacaatgtga agttctgcat agatgccagt      420

caaccagatg ttggaagctg gctcaagtac attagattcg ctggctgtta tgatcagcac      480

aaccttgttg catgccagat aaatgatcag atattctata gagtagttgc agacattgcg      540

ccgggagagg agcttctgct gttcatgaag agcgaagact atccccatga aactatggcg      600

ccggatatcc acgaagaacg gcaatatcgc tgcgaagact gtgaccagct ctttgaatct      660

aaggctgaac tagcagatca ccaaaagttt ccatgcagta ctcctcactc agcattttca      720

atggttgaag aggactttca gcaaaaactc gaaagcgaga atgatctcca agagatacac      780

acgatccagg agtgtaagga atgtgaccaa gtttttcctg atttgcaaag cctggagaaa      840

cacatgctgt cacatactga agagagggaa tacaagtgtg atcagtgtcc caaggcattt      900

aactggaagt ccaatttaat tcgccaccag atgtcacatg acagtggaaa gcactatgaa      960

tgtgaaaact gtgccaaggt tttcacggac cctagcaacc ttcagcggca cattcgctct     1020

cagcatgtcg gtgcccgggc ccatgcatgc ccggagtgtg gcaaaacgtt tgccacttcg     1080

tcgggcctca aacaacacaa gcacatccac agcagtgtga agccctttat ctgtgaggtc     1140

tgccataaat cctatactca gttttcaaac ctttgccgtc ataagcgcat gcatgctgat     1200

tgcagaaccc aaatcaagtg caaagactgt ggacaaatgt tcagcactac gtcttcctta     1260

aataaacaca ggaggttttg tgagggcaag aaccattttg cggcaggtgg attttttggc     1320

caaggcattt cacttcctgg aaccccagct atggataaaa cgtccatggt taatatgagt     1380

catgccaacc cgggccttgc tgactatttt ggcgccaata ggcatcctgc tggtcttacc     1440

tttccaacag ctcctggatt ttcttttagc ttccctggtc tgtttccttc cggcttgtac     1500

cacaggcctc ctttgatacc tgctagttct cctgttaaag gactatcaag tactgaacag     1560

acaaacaaaa gtcaaagtcc cctcatgaca catcctcaga tactgccagc tacacaggat     1620

attttgaagg cactatctaa acacccatct gtaggggaca ataagccagt ggagctccag     1680

cccgagaggt cctctgaaga gaggcccttt gagaaaatca gtgaccagtc agagagtagt     1740

gaccttgatg atgtcagtac accaagtggc agtgacctgg aaacaacctc gggctctgat     1800

ctggaaagtg acattgaaag tgataaagag aaatttaaag aaaatggtaa aatgttcaaa     1860

gacaaagtaa gccctcttca gaatctggct tcaataaata ataagaaaga atacagcaat     1920

cattccattt tctcaccatc tttagaggag cagactgcgg tgtcaggagc tgtgaatgat     1980

tctataaagg ctattgcttc tattgctgaa aaatactttg gttcaacagg actggtgggg     2040

ctgcaagaca aaaaagttgg agctttacct tacccttcca tgtttcccct cccatttttt     2100

ccagcattct ctcaatcaat gtacccattt cctgatagag acttgagatc gttacctttg     2160

aaaatggaac cccaatcacc aggtgaagta aagaaactgc agaagggcag ctctgagtcc     2220

ccctttgatc tcaccactaa gcgaaaggat gagaagccct tgactccagt cccctccaag     2280

cctccagtga cacctgccac aagccaagac cagcccctgg atctaagtat gggcagtagg     2340

agtagagcca gtgggacaaa gctgactgag cctcgaaaaa accacgtgtt tgggggaaaa     2400

aaaggaagca acgtcgaatc aagacctgct tcagatggtt ccttgcagca tgcaagaccc     2460

actcctttct ttatggaccc tatttacaga gtagagaaaa gaaaactaac tgacccactt     2520

gaagctttaa aagagaaata cttgaggcct tctccaggat tcttgtttca cccacaattc     2580

caactgcctg atcagagaac ttggatgtca gctattgaaa acatggcaga aaagctagag     2640

agcttcagtg ccctgaaacc tgaggccagt gagctcttac agtcagtgcc ctctatgttc     2700

aacttcaggg cgcctcccaa tgccctgcca gagaaccttc tgcggaaggg aaaggagcgc     2760

tatacctgca gatactgtgg caagattttt ccaaggtctg caaacctaac acggcacttg     2820

agaacccaca caggagagca gccttacaga tgcaaatact gtgacagatc atttagcata     2880

tcttctaact tgcaaaggca tgttcgcaac atccacaata aagagaagcc atttaagtgt     2940

cacttatgtg ataggtgttt tggtcaacaa accaatttag acagacacct aaagaaacat     3000

gagaatggga acatgtccgg tacagcaaca tcgtcgcctc attctgaact ggaaagtaca     3060

ggtgcgattc tggatgacaa agaagatgct tacttcacag aaattcgaaa tttcattggg     3120

aacagcaacc atggcagcca atctcccagg aatgtggagg agagaatgaa tggcagtcat     3180

tttaaagatg aaaaggcttt ggtgaccagt caaaattcag acttgctgga tgatgaagaa     3240

gttgaagatg aggtgttgtt agatgaggag gatgaagaca atgatattac tggaaaaaca     3300

ggaaaggaac cagtgacaag taatttacat gaaggaaacc ctgaggatga ctatgaagaa     3360

accagtgccc tggagatgag ttgcaagaca tccccagtga ggtataaaga ggaagaatat     3420

aaaagtggac tttctgctct agatcatata aggcacttca cagatagcct caaaatgagg     3480

aaaatggaag ataatcaata ttctgaagct gagctgtctt cttttagtac ttcccatgtg     3540

ccagaggaac ttaagcagcc gttacacaga aagtccaaat cgcaggcata tgctatgatg     3600

ctgtcactgt ctgacaagga gtccctccat tctacatccc acagttcttc caacgtgtgg     3660

cacagtatgg ccagggctgc ggcggaatcc agtgctatcc agtccataag ccacgtatga     3720


<210>  3
<211>  1232
<212>  PRT
<213>  Mus musculus

<400>  3

Met Arg Ser Lys Gly Arg Ala Arg Lys Leu Ala Thr Ser Asn Glu Cys 
1               5                   10                  15      


Ala Tyr Gly Asn Tyr Pro Glu Ile Pro Leu Glu Glu Met Pro Asp Ala 
            20                  25                  30          


Asp Ala Asp Gly Ile Thr Ser Val Pro Ser Leu His Ile Gln Glu Pro 
        35                  40                  45              


Cys Ser Pro Ala Thr Ser Ser Glu Ser Phe Thr Pro Lys Glu Gly Ser 
    50                  55                  60                  


Pro Tyr Lys Ala Pro Ile Tyr Ile Pro Asp Asp Ile Pro Ile Pro Asp 
65                  70                  75                  80  


Glu Phe Glu Leu Arg Glu Ser Thr Met Pro Gly Ala Gly Leu Gly Ile 
                85                  90                  95      


Trp Thr Lys Arg Lys Ile Glu Ile Gly Glu Lys Phe Gly Pro Tyr Met 
            100                 105                 110         


Gly Glu Gln Arg Ser Asp Leu Lys Asp Ser Ser Tyr Gly Trp Glu Ile 
        115                 120                 125             


Leu Asp Glu Phe Cys Asn Val Lys Phe Cys Ile Asp Ala Ser Gln Pro 
    130                 135                 140                 


Asp Val Gly Ser Trp Leu Lys Tyr Ile Arg Phe Ala Gly Cys Tyr Asp 
145                 150                 155                 160 


Gln His Asn Leu Val Ala Cys Gln Ile Asn Asp Gln Ile Phe Tyr Arg 
                165                 170                 175     


Val Val Ala Asp Ile Ala Pro Gly Glu Glu Leu Leu Leu Phe Met Lys 
            180                 185                 190         


Ser Glu Glu Asp Pro His Glu Pro Met Ala Pro Asp Ile His Glu Glu 
        195                 200                 205             


Arg Gln His Arg Cys Glu Asp Cys Asp Gln Leu Phe Glu Ser Lys Ala 
    210                 215                 220                 


Glu Leu Ala Asp His Gln Lys Phe Pro Cys Ser Thr Pro His Ser Ala 
225                 230                 235                 240 


Phe Ser Met Val Glu Glu Asp Leu Gln Gln Asn Leu Glu Ser Glu Ser 
                245                 250                 255     


Asp Leu Arg Glu Ile His Gly Asn Gln Asp Cys Lys Glu Cys Asp Arg 
            260                 265                 270         


Val Phe Pro Asp Leu Gln Ser Leu Glu Lys His Met Leu Ser His Thr 
        275                 280                 285             


Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe Asn Trp 
    290                 295                 300                 


Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly Lys His 
305                 310                 315                 320 


Tyr Glu Cys Glu Asn Cys Ala Lys Val Phe Thr Asp Pro Ser Asn Leu 
                325                 330                 335     


Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His Ala Cys 
            340                 345                 350         


Pro Glu Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys Gln His 
        355                 360                 365             


Lys His Ile His Ser Ser Val Lys Pro Phe Ile Cys Glu Val Cys His 
    370                 375                 380                 


Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg Met His 
385                 390                 395                 400 


Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln Met Phe 
                405                 410                 415     


Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu Gly Lys 
            420                 425                 430         


Asn His Phe Ala Ala Gly Gly Phe Phe Gly Gln Gly Ile Ser Leu Pro 
        435                 440                 445             


Gly Thr Pro Ala Met Asp Lys Thr Ser Met Val Asn Met Ser His Ala 
    450                 455                 460                 


Asn Pro Gly Leu Ala Asp Tyr Phe Gly Thr Asn Arg His Pro Ala Gly 
465                 470                 475                 480 


Leu Thr Phe Pro Thr Ala Pro Gly Phe Ser Phe Ser Phe Pro Gly Leu 
                485                 490                 495     


Phe Pro Ser Gly Leu Tyr His Arg Pro Pro Leu Ile Pro Ala Ser Pro 
            500                 505                 510         


Pro Val Lys Gly Leu Ser Ser Thr Glu Gln Ser Asn Lys Cys Gln Ser 
        515                 520                 525             


Pro Leu Leu Thr His Pro Gln Ile Leu Pro Ala Thr Gln Asp Ile Leu 
    530                 535                 540                 


Lys Ala Leu Ser Lys His Pro Pro Val Gly Asp Asn Lys Pro Val Glu 
545                 550                 555                 560 


Leu Leu Pro Glu Arg Ser Ser Glu Glu Arg Pro Leu Glu Lys Ile Ser 
                565                 570                 575     


Asp Gln Ser Glu Ser Ser Asp Leu Asp Asp Val Ser Thr Pro Ser Gly 
            580                 585                 590         


Ser Asp Leu Glu Thr Thr Ser Gly Ser Asp Leu Glu Ser Asp Leu Glu 
        595                 600                 605             


Ser Asp Lys Glu Lys Cys Lys Glu Asn Gly Lys Met Phe Lys Asp Lys 
    610                 615                 620                 


Val Ser Pro Leu Gln Asn Leu Ala Ser Ile Thr Asn Lys Lys Glu His 
625                 630                 635                 640 


Asn Asn His Ser Val Phe Ser Ala Ser Val Glu Glu Gln Ser Ala Val 
                645                 650                 655     


Ser Gly Ala Val Asn Asp Ser Ile Lys Ala Ile Ala Ser Ile Ala Glu 
            660                 665                 670         


Lys Tyr Phe Gly Ser Thr Gly Leu Val Gly Leu Gln Asp Lys Lys Val 
        675                 680                 685             


Gly Ala Leu Pro Tyr Pro Ser Met Phe Pro Leu Pro Phe Phe Pro Ala 
    690                 695                 700                 


Phe Ser Gln Ser Met Tyr Pro Phe Pro Asp Arg Asp Leu Arg Ser Leu 
705                 710                 715                 720 


Pro Leu Lys Met Glu Pro Gln Ser Pro Ser Glu Val Lys Lys Leu Gln 
                725                 730                 735     


Lys Gly Ser Ser Glu Ser Pro Phe Asp Leu Thr Thr Lys Arg Lys Asp 
            740                 745                 750         


Glu Lys Pro Leu Thr Ser Gly Pro Ser Lys Pro Ser Gly Thr Pro Ala 
        755                 760                 765             


Thr Ser Gln Asp Gln Pro Leu Asp Leu Ser Met Gly Ser Arg Gly Arg 
    770                 775                 780                 


Ala Ser Gly Thr Lys Leu Thr Glu Pro Arg Lys Asn His Val Phe Gly 
785                 790                 795                 800 


Glu Lys Lys Gly Ser Asn Met Asp Thr Arg Pro Ser Ser Asp Gly Ser 
                805                 810                 815     


Leu Gln His Ala Arg Pro Thr Pro Phe Phe Met Asp Pro Ile Tyr Arg 
            820                 825                 830         


Val Glu Lys Arg Lys Leu Thr Asp Pro Leu Glu Ala Leu Lys Glu Lys 
        835                 840                 845             


Tyr Leu Arg Pro Ser Pro Gly Phe Leu Phe His Pro Gln Met Ser Ala 
    850                 855                 860                 


Ile Glu Asn Met Ala Glu Lys Leu Glu Ser Phe Ser Ala Leu Lys Pro 
865                 870                 875                 880 


Glu Ala Ser Glu Leu Leu Gln Ser Val Pro Ser Met Phe Ser Phe Arg 
                885                 890                 895     


Ala Pro Pro Asn Thr Leu Pro Glu Asn Leu Leu Arg Lys Gly Lys Glu 
            900                 905                 910         


Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe Pro Arg Ser Ala Asn 
        915                 920                 925             


Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Gln Pro Tyr Arg Cys 
    930                 935                 940                 


Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser Asn Leu Gln Arg His 
945                 950                 955                 960 


Val Arg Asn Ile His Asn Lys Glu Lys Pro Phe Lys Cys His Leu Cys 
                965                 970                 975     


Asp Arg Cys Phe Gly Gln Gln Thr Asn Leu Asp Arg His Leu Lys Lys 
            980                 985                 990         


His Glu Asn Gly Asn Met Ser Gly  Thr Ala Thr Ser Ser  Pro His Ser 
        995                 1000                 1005             


Glu Leu  Glu Ser Ala Gly Ala  Ile Leu Asp Asp Lys  Glu Asp Ala 
    1010                 1015                 1020             


Tyr Phe  Thr Glu Ile Arg Asn  Phe Ile Gly Asn Ser  Asn His Gly 
    1025                 1030                 1035             


Ser Gln  Ser Pro Arg Asn Met  Glu Glu Arg Met Asn  Gly Ser His 
    1040                 1045                 1050             


Phe Lys  Asp Lys Lys Ala Leu  Ala Thr Ser Gln Asn  Ser Asp Leu 
    1055                 1060                 1065             


Leu Asp  Asp Glu Glu Val Glu  Asp Glu Val Leu Leu  Asp Glu Glu 
    1070                 1075                 1080             


Asp Glu  Asp Asn Asp Ile Pro  Gly Lys Pro Arg Lys  Glu Leu Gly 
    1085                 1090                 1095             


Val Thr  Arg Leu Asp Glu Glu  Ile Pro Glu Asp Asp  Tyr Glu Glu 
    1100                 1105                 1110             


Ala Gly  Ala Leu Glu Met Ser  Cys Lys Ala Ser Pro  Val Arg Tyr 
    1115                 1120                 1125             


Lys Glu  Glu Asp Tyr Lys Ser  Gly Leu Ser Ala Leu  Asp His Ile 
    1130                 1135                 1140             


Arg His  Phe Thr Asp Ser Leu  Lys Met Arg Glu Met  Glu Glu Asn 
    1145                 1150                 1155             


Gln Tyr  Thr Asp Ala Glu Leu  Ser Ser Ile Ser Ser  Ser His Val 
    1160                 1165                 1170             


Pro Glu  Glu Leu Lys Gln Thr  Leu His Arg Lys Ser  Lys Ser Gln 
    1175                 1180                 1185             


Ala Tyr  Ala Met Met Leu Ser  Leu Ser Asp Lys Asp  Ser Leu His 
    1190                 1195                 1200             


Pro Thr  Ser His Ser Ser Ser  Asn Val Trp His Ser  Met Ala Arg 
    1205                 1210                 1215             


Ala Ala  Ala Glu Ser Ser Ala  Ile Gln Ser Ile Ser  His Val 
    1220                 1225                 1230         


<210>  4
<211>  3699
<212>  DNA
<213>  Mus musculus

<400>  4
atgagatcca aaggcagggc aaggaaactg gccacaagta atgagtgtgc ctatggcaac       60

tatcctgaaa tacctttgga agaaatgcca gatgctgatg cagatgggat aaccagtgtt      120

ccctccctcc acattcaaga gccatgctct cctgcgacgt ccagtgagtc atttactcct      180

aaggagggct cgccatacaa agctcccatc tacatccctg atgacatccc tattcctgat      240

gagtttgagc ttcgagagtc aactatgcct ggagcaggac ttggaatatg gaccaaaagg      300

aagattgaaa taggcgaaaa gtttgggcca tacatgggag agcagagatc agacctgaaa      360

gattccagct atggatggga gatcttagat gagttttgca atgtgaagtt ctgcatagat      420

gccagtcaac cagatgtagg aagctggctc aagtacatca gattcgctgg ctgctatgat      480

cagcacaacc ttgttgcatg ccagataaat gatcagatat tctaccgagt agtcgcagac      540

attgcgcctg gggaagagct cttgctgttc atgaagagtg aagaggaccc gcacgaaccc      600

atggcgcctg acatccacga agaacggcag caccgctgtg aggactgtga ccagctcttt      660

gaatccaagg cagagctagc cgatcaccag aagttcccat gcagcacacc tcactcggcc      720

ttctccatgg tggaggagga cttgcaacaa aacctggaga gtgagagcga tctccgagag      780

atccatggca accaggactg taaggaatgt gaccgagttt tccccgatct gcaaagcttg      840

gagaagcaca tgctgtcaca tactgaggag agggaataca agtgtgatca gtgtcccaag      900

gcatttaact ggaagtccaa tttaattcgc caccagatgt cacatgacag tggaaagcac      960

tatgagtgtg aaaactgtgc caaggttttc acggacccta gcaaccttca gcgacacatt     1020

cgatctcagc atgttggtgc ccgggctcat gcttgccccg agtgtggtaa aacatttgcc     1080

acttcgtcag gcctcaaaca gcacaagcac atccacagca gtgtgaagcc ctttatctgt     1140

gaggtctgcc ataaatccta tactcagttt tcaaaccttt gtcgtcataa gcgcatgcat     1200

gctgattgca gaacccaaat caagtgcaaa gactgtggac aaatgttcag cactacgtct     1260

tccttaaata aacacaggag gttttgtgag ggcaagaacc attttgcggc aggtggattt     1320

tttggccaag gcatttcact tcctggaacc ccagctatgg ataaaacgtc catggttaat     1380

atgagtcatg ccaacccggg cctggctgac tattttggca ccaataggca tcctgctggt     1440

cttacctttc caacagctcc tggattttcc tttagctttc ctggtctgtt tccttcgggc     1500

ttataccaca ggcctccttt gatacccgct agtcctcctg ttaaaggatt atcaagtacc     1560

gaacagtcaa acaaatgtca aagtcccctc ttgacacatc ctcagatact gccagctaca     1620

caggatattt tgaaggcact atctaaacac ccacctgtag gggacaataa gccagtggaa     1680

ctgctgcccg agaggtcctc tgaagagagg ccccttgaga aaatcagtga ccagtcagag     1740

agtagtgacc ttgatgatgt cagtacacca agtggcagtg acctggaaac aacctcgggc     1800

tctgatctgg aaagtgacct tgaaagtgat aaagagaaat gtaaagaaaa tggtaaaatg     1860

ttcaaagaca aagtaagccc tctgcagaat ctggcttcga taactaataa gaaagaacac     1920

aacaatcatt ccgttttctc agcatctgta gaggagcaaa gtgccgtgtc aggagctgtg     1980

aatgattcta taaaggctat tgcgtctatt gctgaaaaat actttggttc tacaggactg     2040

gtggggctgc aagacaaaaa agttggagcg ttaccttacc cttccatgtt tcccctcccg     2100

ttttttccag cattctctca atcaatgtac ccatttcctg atagagactt gaggtcgtta     2160

cctttgaaaa tggagcccca atcaccaagt gaagttaaga aactgcagaa gggaagctct     2220

gagtcccctt ttgacctcac cactaagaga aaggatgaga agcccttgac ttcaggcccc     2280

tcgaagcctt caggaacacc agccacaagc caagaccagc ccctggatct aagtatgggc     2340

agtaggggta gagccagtgg gacaaagttg actgagcctc gaaaaaacca tgtgtttggg     2400

gaaaagaaag gaagcaacat ggatactagg ccatcttcag atggctcctt gcagcatgcc     2460

agacccactc ccttcttcat ggaccccatt tatagagtag agaaaagaaa gttaactgac     2520

ccgcttgaag ctttgaaaga aaaatacttg agaccttctc caggattctt gtttcacccg     2580

caaatgtcag caattgagaa catggcagaa aagctggaaa gcttcagcgc cctcaaacct     2640

gaggccagcg agctcctgca gtccgtgccc tccatgttca gcttccgagc tcctcccaac     2700

accctgccag agaacctgct gcggaagggg aaagagcgct acacctgcag gtactgtggc     2760

aagatatttc caaggtctgc gaacctaaca cggcacttga gaacccacac aggagagcaa     2820

ccttacagat gcaaatactg tgatagatca ttcagcattt cttccaacct gcagcgacat     2880

gtgcgcaaca tccacaacaa ggagaagcca tttaagtgtc atttatgtga cagatgtttt     2940

ggtcaacaaa ccaatcttga cagacacctg aagaaacatg agaacggcaa catgtctggg     3000

acggcaacgt cctcgcctca ctcagagcta gaaagcgcag gcgcaatcct ggatgacaaa     3060

gaagatgcgt actttacaga gatccgcaat ttcatcggga acagcaacca tggtagccag     3120

tctcctcgga acatggaaga gaggatgaat ggcagtcact tcaaggataa aaaggctttg     3180

gcaaccagcc aaaattcaga tttattggat gatgaagaag tagaagatga ggtgttgttg     3240

gatgaggagg atgaagacaa tgatattcct ggaaagccca gaaaggagct aggggtgact     3300

cgtttagacg aggagatccc ggaggatgac tacgaagaag ctggtgccct ggagatgagc     3360

tgtaaggcgt ccccggtgag gtataaagag gaagactata aatctggcct ttctgctcta     3420

gatcacataa ggcacttcac agatagcctc aaaatgaggg aaatggaaga gaatcaatac     3480

actgacgctg agctgtcctc cattagttct tctcatgtgc cagaggagct taaacagacg     3540

ttacacagaa agtccaaatc acaggcatat gctatgatgt tgtcactgtc tgacaaggat     3600

tccctccatc ccacctccca cagttcctcc aacgtgtggc acagcatggc aagggctgca     3660

gcagaatcca gtgccatcca gtccataagc catgtatga                            3699


<210>  5
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  ME Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa at position 39 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa at position 50 is any amino acid

<400>  5

Leu Arg Glu Ser Xaa Met Pro Gly Ala Gly Leu Gly Ile Trp Thr Lys 
1               5                   10                  15      


Arg Lys Ile Glu Xaa Gly Glu Lys Phe Gly Pro Tyr Xaa Gly Glu Gln 
            20                  25                  30          


Arg Ser Xaa Leu Lys Asp Xaa Ser Tyr Gly Trp Glu Ile Leu Asp Glu 
        35                  40                  45              


Phe Xaa Asn Val Lys Phe Cys Ile Asp Ala Ser Gln Pro Asp Val Gly 
    50                  55                  60                  


Ser Trp Leu Lys Tyr Ile Arg Phe Ala Gly Cys Tyr Asp Gln His Asn 
65                  70                  75                  80  


Leu Val Ala Cys Gln Ile Asn Asp Gln Ile Phe Tyr Arg Val Val Ala 
                85                  90                  95      


Asp Ile Ala Pro Gly Glu Glu Leu Leu Leu Phe Met Lys Ser 
            100                 105                 110 


<210>  6
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence encoding shRNA designated sh11

<400>  6
gatccgagcg cctgacatcc acgaagaact tcaagagagt tcttcgtgga tgtcaggcgc       60

tttttacgcg tg                                                           72


<210>  7
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence encoding shRNA designated sh54

<400>  7
gatccgagtt gttggatgag gaggatgaat tcaagagatt catcctcctc atccaacaac       60

tttttacgcg tg                                                           72


<210>  8
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence encoding shRNA targeting murine ME PR domain

<400>  8
cctattcctg atgagtttga gcttca                                            26


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence encoding SiRNA targeting human ME PR domain

<400>  9
gccagataaa tgatcagata t                                                 21


<210>  10
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  RNAi targeting human ME

<400>  10
uucugcauag augccaguca acc                                               23


<210>  11
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  RNAi targeting human ME

<400>  11
gggcaggacu aggaauaugg acc                                               23


<210>  12
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Aptamer

<400>  12
atccagagtg acgcagcatg ccctagttac tactactctt tttagcaaac gccctcgctt       60

tggacacggt ggcttagt                                                     78


<210>  13
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  13
atgaattcgc atgagatcca aaggcagggc                                        30


<210>  14
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  14
atgaattctt cacctggtct cccatccata gctg                                   34


<210>  15
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  15

Asp Asp Ile Pro Ile Pro Asp Glu Phe Glu Leu Arg Glu Ser Thr Met 
1               5                   10                  15      


Pro Gly Ala Gly Leu Gly Ile Trp Thr Lys Arg Lys Ile Glu Val Gly 
            20                  25                  30          


Glu Lys Phe Gly Pro Tyr Val Gly Glu Gln Arg Ser Asn Leu Lys Asp 
        35                  40                  45              


Pro Ser Tyr Gly Trp Glu Ile Leu Asp Glu Phe Cys Asn Val Lys Phe 
    50                  55                  60                  


Cys Ile Asp Ala Ser Gln Pro Asp Val Gly Ser Trp Leu Lys Tyr Ile 
65                  70                  75                  80  


Arg Phe Ala Gly Cys Tyr Asp Gln His Asn Leu Val Ala Cys Gln Ile 
                85                  90                  95      


Asn Asp Gln Ile Phe Tyr Arg Val Val Ala Asp Ile Ala Pro Gly Glu 
            100                 105                 110         


Glu Leu Leu Leu Phe Met Lys Ser Glu Glu Asp Tyr Pro His Glu 
        115                 120                 125         


<210>  16
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  16

Tyr Asp Leu Cys Ile Phe Arg Thr Asp Asp Gly Arg Gly Trp Gly Val 
1               5                   10                  15      


Arg Thr Leu Glu Lys Ile Arg Lys Asn Ser Phe Val Met Glu Tyr Val 
            20                  25                  30          


Gly Glu Ile Ile Thr Ser Glu Glu Ala Glu Arg Arg Asp Tyr Val Glu 
        35                  40                  45              


Asp Val Tyr Thr Val Asp Ala Ala Tyr Tyr Gly Asn Ile Ser His Phe 
    50                  55                  60                  


Val Asn His Ser Cys Asp Pro Asn Leu Gln Val Tyr Asn Val Phe Ile 
65                  70                  75                  80  


Asp Asn Leu Asp Glu Arg Leu Pro Arg Ile Ala Phe Phe Ala Thr Arg 
                85                  90                  95      


Thr Ile Arg Ala Gly Glu Glu Leu Thr Phe Asp Tyr Asn Met Gln Val 
            100                 105                 110         


<210>  17
<211>  114
<212>  PRT
<213>  P. sativa

<400>  17

Glu Glu Gly Val Ile Thr Ala Lys Thr Pro Val Lys Ala Ser Val Val 
1               5                   10                  15      


Thr Glu Gly Leu Gly Leu Val Ala Leu Lys Asp Ile Ser Arg Asn Asp 
            20                  25                  30          


Val Ile Leu Gln Val Pro Lys Arg Leu Trp Ile Asn Arg Ala Phe Ser 
        35                  40                  45              


Arg Leu Arg Asn Glu Asn Leu Val Val Val Pro Met Ala Asp Leu Ile 
    50                  55                  60                  


Asn His Ser Ala Gly Val Thr Thr Glu Asp His Ala Tyr Glu Val Lys 
65                  70                  75                  80  


Gly Ala Ala Gly Leu Phe Ser Trp Asp Tyr Leu Phe Ser Leu Lys Ser 
                85                  90                  95      


Pro Leu Ser Val Lys Ala Gly Glu Gln Val Tyr Ile Gln Tyr Asp Leu 
            100                 105                 110         


Asn Lys 
        


<210>  18
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Lys Asn Glu Phe Ile 
1               5                   10                  15      


Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg 
            20                  25                  30          


Gly 
    


<210>  19
<211>  34
<212>  PRT
<213>  Mus musculus

<400>  19

Ala Gly Trp Gly Thr Phe Ile Lys Glu Ser Val Gln Lys Asn Glu Phe 
1               5                   10                  15      


Ile Ser Glu Tyr Cys Gly Glu Leu Ile Ser Gln Asp Glu Ala Asp Arg 
            20                  25                  30          


Arg Gly 
        


<210>  20
<211>  34
<212>  PRT
<213>  Drosophila melanogaster

<400>  20

Ala Gly Trp Gly Ile Phe Leu Lys Glu Gly Ala Gln Lys Asn Glu Phe 
1               5                   10                  15      


Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg 
            20                  25                  30          


Arg Gly 
        


<210>  21
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  21

His Gly Arg Gly Leu Phe Cys Lys Arg Asn Ile Asp Ala Gly Glu Met 
1               5                   10                  15      


Val Ile Glu Tyr Ala Gly Asn Val Ile Arg Ser Ile Gln Thr Asp Lys 
            20                  25                  30          


Arg Glu 
        


