                         SEQUENCE LISTING

<110>  NewSouth Innovations Pty Limited
 
<120>  Methods for inhibiting neuron apoptosis and necrosis

<130>  35110554/GDR/TKU

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  2427
<212>  DNA
<213>  Mus musculus

<400>  1
atgcgtgaca agggccggcg ccaggcagtg cgtggcccgg ccttcatgtt cggtgctcgt       60

gggcccagcc tcacagctga ggaggagcgc ttcctggatg ctgcggagta cggcaacatc      120

cctgtggtgc gcaagatgct ggaggagtct cgcacgctca atgtcaactg cgtggactac      180

atgggccaga acgcactgca gctggctgta ggcaatgagc atctggaggt gaccgagctg      240

ctgctgaaga aggagaacct ggcgcggatc ggtgatgcgc tgctgctagc catcagcaag      300

ggctatgtac gcatcgtgga ggccatcctg ggccacccag gctttgcagc cagccggcgc      360

ctgaccctca gcccttgcga gcaagaactg cgagatgatg acttctatgc ctatgacgag      420

gatggcacac gcttctcgcc tgacatcacg cccatcatcc tggctgcaca ctgccataag      480

tacgaggtgg tgcacctgct gctactcaag ggtgcacgca tcgagaggcc acacgactac      540

ttctgtcgct gctctgactg cgctgagaaa caaaggcttg acgccttcag ccactcaagg      600

tctaggatca atgcctacaa gggactggcc agcccagcat acttgtcgct gtccagcgag      660

gaccccgtgc tcacagcact ggaactcagc aatgagctgg ccaagctggc caacatagag      720

aaggagttca agaatgacta caggaaactc tccatgcaat gcaaagactt cgtagtgggt      780

gtgctggacc tgtgtcggga ctcggaggag gtggaagcca ttctgaatgg agatctggaa      840

tcagccgagc ccctggaaag acacgggcac aaagcgtcac tgagtcgtgt caaacttgcc      900

attaagtatg aagtcaaaaa gtttgtggct caccccaact gccaacagca gcttttgacg      960

atctggtatg agaacctctc cggcctccgg gagcagacca tcgctatcaa gtgtctggtc     1020

gtgttggtcg tggccttggg tcttccattc ctcgccattg gctattggat tgcaccttgt     1080

agcaggctgg ggaagattct tcgaagcccc ttcatgaagt tcgtggccca cgctgcctcc     1140

ttcatcatct ttctgggtct gctcgtattc aacgcctcgg acaggtttga aggcatcacc     1200

acgctgccaa acatcactgt tatcgactac cccaagcaaa tcttcagggt gaagaccacc     1260

cagtttacat ggacggaaat gttaattatg gtctgggttc ttgggatgat gtggtctgag     1320

tgcaaggagc tgtggctgga ggggccccgg gagtacatcg tgcagttgtg gaatgtgctt     1380

gatttcggca tgctctccat cttcatcgcc gcgttcacag ccaggttcct cgctttcctg     1440

caggccacga aggcgcagca gtatgtggat agtcacgtgc aggagagcga tctgagcgaa     1500

gtcacgctcc cacctgaggt tcaatatttc acctatgcta gagacaaatg gctcccctca     1560

gaccctcaga tcatatctga agggctctat gccatagctg tggtgctcag cttctcccgg     1620

attgcgtaca tcctccctgc aaacgagagc tttgggccct tgcagatctc tcttggaagg     1680

actgtgaagg acatattcaa gttcatggtt ctcttcatta tggtgttcct ggctttcatg     1740

attggcatgt tcatacttta ttcttactac cttggggcca aagtaaatcc tgcttttacc     1800

acggttgaag aaagtttcaa gactttgttt tggtccatat ttggactgtc tgaagtgact     1860

tctgttgtcc tcaaatatga tcacaaattc atagagaata ttggctatgt tctttatggg     1920

atatataatg taactatggt ggtcgtttta ctcaacatgc taattgctat gattaatagc     1980

tcataccaag agatcgagga tgacagtgat gtagaatgga agtttgctcg ttccaaactt     2040

tggctctcct actttgatga tggaaaaaca ttacctccac ccttcagtct ggtccctagt     2100

ccaaagtcat ttgtttactt catcatgagg atcactaact tttccaaatg caggaggaga     2160

agactgcaga aggatctgga actgggcatg ggtaactcaa agtccaggca gataatgaaa     2220

agactcataa aacggtatgt tttgaaagca caagtagaca aagaaaacga tgaggtgaat     2280

gaaggtgaac tgaaagaaat caagcaggat atctccagcc ttcgttatga actcttagaa     2340

gataagagcc aagcgacgga ggaattagcc atcttgattc ataaactcag tgagaaactg     2400

aaccccagtg tgctgagatg tgagtga                                         2427


<210>  2
<211>  808
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Asp Lys Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met 
1               5                   10                  15      

Phe Gly Ala Arg Gly Pro Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu 
            20                  25                  30          

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
        35                  40                  45              

Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn 
    50                  55                  60                  

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
65                  70                  75                  80  

Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu 
                85                  90                  95      

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Gly His 
            100                 105                 110         

Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys Glu Gln 
        115                 120                 125             

Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
    130                 135                 140                 

Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys His Lys 
145                 150                 155                 160 

Tyr Glu Val Val His Leu Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
                165                 170                 175     

Pro His Asp Tyr Phe Cys Arg Cys Ser Asp Cys Ala Glu Lys Gln Arg 
            180                 185                 190         

Leu Asp Ala Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly 
        195                 200                 205             

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
    210                 215                 220                 

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu 
225                 230                 235                 240 

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
                245                 250                 255     

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu 
            260                 265                 270         

Ala Ile Leu Asn Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Arg His 
        275                 280                 285             

Gly His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu 
    290                 295                 300                 

Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr 
305                 310                 315                 320 

Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile 
                325                 330                 335     

Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala 
            340                 345                 350         

Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg 
        355                 360                 365             

Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe 
    370                 375                 380                 

Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr 
385                 390                 395                 400 

Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile Phe Arg 
                405                 410                 415     

Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp 
            420                 425                 430         

Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly 
        435                 440                 445             

Pro Arg Glu Tyr Ile Val Gln Leu Trp Asn Val Leu Asp Phe Gly Met 
    450                 455                 460                 

Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu 
465                 470                 475                 480 

Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser His Val Gln Glu Ser 
                485                 490                 495     

Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Val Gln Tyr Phe Thr Tyr 
            500                 505                 510         

Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly 
        515                 520                 525             

Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile 
    530                 535                 540                 

Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg 
545                 550                 555                 560 

Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe 
                565                 570                 575     

Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly 
            580                 585                 590         

Ala Lys Val Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr 
        595                 600                 605             

Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu 
    610                 615                 620                 

Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly 
625                 630                 635                 640 

Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala 
                645                 650                 655     

Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu 
            660                 665                 670         

Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly 
        675                 680                 685             

Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe 
    690                 695                 700                 

Val Tyr Phe Ile Met Arg Ile Thr Asn Phe Ser Lys Cys Arg Arg Arg 
705                 710                 715                 720 

Arg Leu Gln Lys Asp Leu Glu Leu Gly Met Gly Asn Ser Lys Ser Arg 
                725                 730                 735     

Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val 
            740                 745                 750         

Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys 
        755                 760                 765             

Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln 
    770                 775                 780                 

Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys Leu 
785                 790                 795                 800 

Asn Pro Ser Val Leu Arg Cys Glu 
                805             


<210>  3
<211>  2511
<212>  DNA
<213>  Mus musculus

<400>  3
atgcgtgaca agggccggcg ccaggcagtg cgtggcccgg ccttcatgtt cggtgctcgt       60

gggcccagcc tcacagctga ggaggagcgc ttcctggatg ctgcggagta cggcaacatc      120

cctgtggtgc gcaagatgct ggaggagtct cgcacgctca atgtcaactg cgtggactac      180

atgggccaga acgcactgca gctggctgta ggcaatgagc atctggaggt gaccgagctg      240

ctgctgaaga aggagaacct ggcgcggatc ggtgatgcgc tgctgctagc catcagcaag      300

ggctatgtgc gcatcgtgga ggccatcctg ggccacccag gctttgcagc cagccggcgc      360

ctgaccctca gcccttgcga gcaagaactg cgagatgatg acttctatgc ttacgacgag      420

gatggcacac gcttctcgcc tgacatcacg cccatcatcc tggctgcaca ctgccataag      480

tacgaggtgg tgcacctgct gctactcaag ggtgcacgca tcgagaggcc acacgactac      540

ttctgtcgct gctctgactg cgctgagaaa caaaggcttg acgccttcag ccactcaagg      600

tctaggatca atgcctacaa gggactggcc agcccagcat acttgtcgct gtccagcgag      660

gaccccgtgc tcacagcact ggagctcagc aatgagctgg ccaagctggc caacatagag      720

aaggagttca agaatgacta caggaaactc tccatgcaat gcaaagactt cgtagtgggt      780

gtgctggacc tgtgtcggga ctcggaggag gtggaagcca ttctgaatgg agatctggaa      840

tcagccgagc ccctggaaag acacgggcac aaagcgtcac tgagtcgtgt caaacttgcc      900

attaagtatg aagtcaaaaa gtttgtggct caccccaact gccaacagca gcttttgaca      960

atctggtatg agaacctttc cggcctccgg gagcagacca tcgctatcaa gtgtctggtc     1020

gtgttggtcg tggccttggg tcttccattc ctcgccatcg gctattggat tgcaccttgt     1080

agcaggctgg ggaagattct tcgaagcccc ttcatgaagt ttgtggccca cgctgcctcc     1140

ttcatcatct ttctgggtct gcttgtattc aacgcctcgg acagatttga aggcatcacc     1200

acgctgccaa acatcactgt tatcgactac cccaagcaaa tcttcagggt gaagacaacc     1260

cagttcacgt ggacggaaat gttaattatg gtctgggttc ttgggatgat gtggtctgag     1320

tgcaaggagc tgtggctgga ggggcccggg gagtacatcg tgcagttgtg gaatgtgctt     1380

gatttcggca tgctctccat cttcatcgcc gcgttcacag ccaggttcct cgctttcctg     1440

caggccacga aggcgcagca gtatgtggat agtcacgtgc aggagagcga tctgagcgaa     1500

gtcacgctcc cacctgaggt tcaatatttc acctatgcta gagacaaatg gctcccctca     1560

gaccctcaga tcatatctga agggctctat gccatagctg tggtgctcag cttctcccgg     1620

attgcgtaca tcctccctgc aaacgagagc tttgggccct tgcagatctc tcttggaagg     1680

actgtgaagg acatattcaa gttcatggtt ctcttcatta tggtgttcct ggctttcatg     1740

attggcatgt tcatacttta ttcttactac cttggggcca aagtaaatcc tgcttttacc     1800

acggttgaag aaagtttcaa gactttgttt tggtccatat ttggactgtc tgaagtgact     1860

tctgttgtcc tcaaatatga tcacaaattc atagagaata ttggctatgt tctttatggg     1920

atatataatg taactatggt ggtcgtttta ctcaacatgc taattgctat gattaatagc     1980

tcataccaag agatcgagga tgacagtgat gtagaatgga agtttgctcg ttccaaactt     2040

tggctctcct acttcgatga tggaaaaaca ttacctccac ccttcagtct ggtccctagt     2100

ccaaaatcat ttgtttactt catcatgagg atcactaact tttccaaatg caggaggaga     2160

agactgcaga aggatctgga actgggcatg ggtaactcaa agtccaggtt aaacctcttc     2220

acacagtcta actcgagagt ttttgaatca cacagtttta acagcattct caatcagcca     2280

acacgatatc agcagataat gaaaagactc ataaaacggt atgttttgaa agcacaagta     2340

gacaaagaaa acgatgaggt gaatgaaggt gaactgaaag aaatcaagca ggatatctcc     2400

agccttcgtt atgaactttt agaagataag agccaagcga cggaggaatt agccatcttg     2460

attcataaac tcagtgagaa actgaacccc agtgtgctga gatgtgagtg a              2511


<210>  4
<211>  836
<212>  PRT
<213>  Mus musculus

<400>  4

Met Arg Asp Lys Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met 
1               5                   10                  15      

Phe Gly Ala Arg Gly Pro Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu 
            20                  25                  30          

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
        35                  40                  45              

Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn 
    50                  55                  60                  

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
65                  70                  75                  80  

Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu 
                85                  90                  95      

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Gly His 
            100                 105                 110         

Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys Glu Gln 
        115                 120                 125             

Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
    130                 135                 140                 

Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys His Lys 
145                 150                 155                 160 

Tyr Glu Val Val His Leu Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
                165                 170                 175     

Pro His Asp Tyr Phe Cys Arg Cys Ser Asp Cys Ala Glu Lys Gln Arg 
            180                 185                 190         

Leu Asp Ala Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly 
        195                 200                 205             

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
    210                 215                 220                 

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu 
225                 230                 235                 240 

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
                245                 250                 255     

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu 
            260                 265                 270         

Ala Ile Leu Asn Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Arg His 
        275                 280                 285             

Gly His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu 
    290                 295                 300                 

Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr 
305                 310                 315                 320 

Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile 
                325                 330                 335     

Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala 
            340                 345                 350         

Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg 
        355                 360                 365             

Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe 
    370                 375                 380                 

Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr 
385                 390                 395                 400 

Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile Phe Arg 
                405                 410                 415     

Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp 
            420                 425                 430         

Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly 
        435                 440                 445             

Pro Gly Glu Tyr Ile Val Gln Leu Trp Asn Val Leu Asp Phe Gly Met 
    450                 455                 460                 

Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu 
465                 470                 475                 480 

Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser His Val Gln Glu Ser 
                485                 490                 495     

Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Val Gln Tyr Phe Thr Tyr 
            500                 505                 510         

Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly 
        515                 520                 525             

Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile 
    530                 535                 540                 

Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg 
545                 550                 555                 560 

Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe 
                565                 570                 575     

Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly 
            580                 585                 590         

Ala Lys Val Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr 
        595                 600                 605             

Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu 
    610                 615                 620                 

Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly 
625                 630                 635                 640 

Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala 
                645                 650                 655     

Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu 
            660                 665                 670         

Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly 
        675                 680                 685             

Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe 
    690                 695                 700                 

Val Tyr Phe Ile Met Arg Ile Thr Asn Phe Ser Lys Cys Arg Arg Arg 
705                 710                 715                 720 

Arg Leu Gln Lys Asp Leu Glu Leu Gly Met Gly Asn Ser Lys Ser Arg 
                725                 730                 735     

Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser 
            740                 745                 750         

Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys 
        755                 760                 765             

Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn 
    770                 775                 780                 

Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser 
785                 790                 795                 800 

Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu 
                805                 810                 815     

Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Val 
            820                 825                 830         

Leu Arg Cys Glu 
        835     


<210>  5
<211>  2433
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atggcgaggc cgagggagcc gagccgcagc gccgccgccg gggctggagg ggcgtcaacg       60

gcgggctgga gccgccctgc ccgcgcgcgc cgccgtcccc ggggcccgac gcagtacggc      120

aacatccctg tggtgcgcaa gatgctggag gagtctcgca cgctcaatgt caactgcgtg      180

gactacatgg gccagaatgc gctgcagctg gccgtgggca atgagcatct ggaggtgacc      240

gagctgctgc tgaagaagga gaacctggcg cgtatcggtg atgcgctgct gctcgccatc      300

agcaaaggct atgtgcgcat cgtggaggcc atcctaggcc acccaggctt tgcggccagc      360

cggcgcctga ccctcagccc ttgcgagcaa gaactgcgcg atgacgactt ctatgcttac      420

gacgaggatg gcacacgctt ctcacctgac atcacgccca tcatcctggc tgcgcattgc      480

cataaatacg aggtggtgca cctgctgcta ctcaagggtg cacgcatcga gcggccacac      540

gactacttct gtcgctgcgc cgactgtgct gagaagcaaa ggcttgatgc cttcagccac      600

tcaaggtcta ggatcaatgc ctacaaggga ctggccagcc cagcatactt gtcgctgtcc      660

agcgaggacc ctgtgctcac agcgctggaa ctcagcaatg agctggccaa gctggccaac      720

atagagaagg agttcaagaa tgactacagg aagctctcca tgcagtgcaa agacttcgta      780

gtaggtgtgc tggacctgtg ccgggactca gaggaggtgg aagccattct gaatggagat      840

ctggaatcgg tggaacccct ggagagacac gggcacaagg cgtcgctgag tcgggtcaaa      900

cttgccatta aatatgaagt caaaaagttt gtggctcacc ccaactgcca acagcagctt      960

ttgaccatct ggtacgagaa cctctcgggc cttcgggagc agaccatcgc tatcaagtgt     1020

ctggtcgtgt tggtcgtggc cttgggcctt ccattcctcg ccatcggcta ctggattgca     1080

ccttgtagca ggctggggaa aattcttcga agccccttca tgaagttcgt ggctcacgct     1140

gcctccttca tcatcttcct gggtctgctt gtgttcaacg cctcagaccg gtttgaaggc     1200

atcaccacgc tgcccaacat caccgttatt gactacccca agcaaatctt cagggtgaag     1260

accacccagt tcacatggac agaaatgcta attatggtct gggttctcgg gatgatgtgg     1320

tctgagtgca aggagctgtg gctggagggg ccccgggagt acatcgtgca gctgtggaac     1380

gtgcttgact tcgggatgct ctccatcttc attgctgcct tcaccgccag gttcctagcg     1440

tttctgcaag ccaccaaagc gcagcagtat gtggacagcc acgtgcagga gagcgacctg     1500

agcgaagtca cactcccacc agaggttcag tatttcacct atgctagaga taaatggctt     1560

ccttctgacc ctcagatcat atcggaaggc ctctatgcca tagctgtggt gctcagcttc     1620

tcccggatcg cgtacattct ccctgcaaac gagagctttg ggcccttgca gatctctctg     1680

gggaggactg tgaaggacat attcaagttc atggttctct tcatcatggt gttcctggct     1740

ttcatgattg gcatgttcat actttactcc tactaccttg gggccaaagt aaaccctgct     1800

tttaccacgg ttgaagaaag tttcaagact ttgttttggt ccatatttgg actctctgaa     1860

gtgacttctg ttgtcctcaa atatgaccac aaattcatag agaacattgg ctatgtcctt     1920

tatggaatat acaatgtaac tatggtggtc gttctgctca acatgctgat tgctatgatt     1980

aacagctcat accaagaaat cgaggatgac agtgatgtag agtggaagtt tgctcgttcc     2040

aaactctggc tatcctactt cgatgatgga aaaacattac ctccaccctt cagtctggtc     2100

cctagtccaa aatcgtttgt ttatttcatc atgaggatca ctaacttttc caaatgcagg     2160

aggagaagac ttcagaagga tctggaactg ggcatgggta actcaaagtc caggcagata     2220

atgaaaagac tcataaaacg gtatgttttg aaagcacaag tagacaaaga aaatgatgag     2280

gtgaacgaag gtgaactgaa agaaatcaag caggatatct ccagccttcg ttacgaactt     2340

ttggaagata agagccaagc gacggaggaa ctggccatct tgattcataa actcagtgag     2400

aaactgaacc ccagtgcgct gaggtgtgaa tga                                  2433


<210>  6
<211>  810
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Ala Arg Pro Arg Glu Pro Ser Arg Ser Ala Ala Ala Gly Ala Gly 
1               5                   10                  15      

Gly Ala Ser Thr Ala Gly Trp Ser Arg Pro Ala Arg Ala Arg Arg Arg 
            20                  25                  30          

Pro Arg Gly Pro Thr Gln Tyr Gly Asn Ile Pro Val Val Arg Lys Met 
        35                  40                  45              

Leu Glu Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly 
    50                  55                  60                  

Gln Asn Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr 
65                  70                  75                  80  

Glu Leu Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu 
                85                  90                  95      

Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu 
            100                 105                 110         

Gly His Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys 
        115                 120                 125             

Glu Gln Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly 
    130                 135                 140                 

Thr Arg Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys 
145                 150                 155                 160 

His Lys Tyr Glu Val Val His Leu Leu Leu Leu Lys Gly Ala Arg Ile 
                165                 170                 175     

Glu Arg Pro His Asp Tyr Phe Cys Arg Cys Ala Asp Cys Ala Glu Lys 
            180                 185                 190         

Gln Arg Leu Asp Ala Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr 
        195                 200                 205             

Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro 
    210                 215                 220                 

Val Leu Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn 
225                 230                 235                 240 

Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys 
                245                 250                 255     

Lys Asp Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu 
            260                 265                 270         

Val Glu Ala Ile Leu Asn Gly Asp Leu Glu Ser Val Glu Pro Leu Glu 
        275                 280                 285             

Arg His Gly His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys 
    290                 295                 300                 

Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu 
305                 310                 315                 320 

Leu Thr Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile 
                325                 330                 335     

Ala Ile Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe 
            340                 345                 350         

Leu Ala Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile 
        355                 360                 365             

Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile 
    370                 375                 380                 

Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly 
385                 390                 395                 400 

Ile Thr Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile 
                405                 410                 415     

Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met 
            420                 425                 430         

Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu 
        435                 440                 445             

Glu Gly Pro Arg Glu Tyr Ile Val Gln Leu Trp Asn Val Leu Asp Phe 
    450                 455                 460                 

Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala 
465                 470                 475                 480 

Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser His Val Gln 
                485                 490                 495     

Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Val Gln Tyr Phe 
            500                 505                 510         

Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser 
        515                 520                 525             

Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala 
    530                 535                 540                 

Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu 
545                 550                 555                 560 

Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met 
                565                 570                 575     

Val Phe Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr 
            580                 585                 590         

Leu Gly Ala Lys Val Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe 
        595                 600                 605             

Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val 
    610                 615                 620                 

Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu 
625                 630                 635                 640 

Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu 
                645                 650                 655     

Ile Ala Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp 
            660                 665                 670         

Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp 
        675                 680                 685             

Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys 
    690                 695                 700                 

Ser Phe Val Tyr Phe Ile Met Arg Ile Thr Asn Phe Ser Lys Cys Arg 
705                 710                 715                 720 

Arg Arg Arg Leu Gln Lys Asp Leu Glu Leu Gly Met Gly Asn Ser Lys 
                725                 730                 735     

Ser Arg Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala 
            740                 745                 750         

Gln Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu 
        755                 760                 765             

Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys 
    770                 775                 780                 

Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu 
785                 790                 795                 800 

Lys Leu Asn Pro Ser Ala Leu Arg Cys Glu 
                805                 810 


<210>  7
<211>  2517
<212>  DNA
<213>  Rattus norvegicus

<400>  7
atggcgaggc cgagggagcc gagccgcagc gccgccgccg gggctggagg ggcgtcaacg       60

gcgggctgga gccgccctgc ccgcgcgcgc cgccgtcccc ggggcccgac gcagtacggc      120

aacatccctg tggtgcgcaa gatgctggag gagtctcgca cgctcaatgt caactgcgtg      180

gactacatgg gccagaatgc gctgcagctg gccgtgggca atgagcatct ggaggtgacc      240

gagctgctgc tgaagaagga gaacctggcg cgtatcggtg atgcgctgct gctcgccatc      300

agcaaaggct atgtgcgcat cgtggaggcc atcctaggcc acccaggctt tgcggccagc      360

cggcgcctga ccctcagccc ttgcgagcaa gaactgcgcg atgacgactt ctatgcttac      420

gacgaggatg gcacacgctt ctcacctgac atcacgccca tcatcctggc tgcgcattgc      480

cataaatacg aggtggtgca cctgctgcta ctcaagggtg cacgcatcga gcggccacac      540

gactacttct gtcgctgcgc cgactgtgct gagaagcaaa ggcttgatgc cttcagccac      600

tcaaggtcta ggatcaatgc ctacaaggga ctggccagcc cagcatactt gtcgctgtcc      660

agcgaggacc ctgtgctcac agcgctggaa ctcagcaatg agctggccaa gctggccaac      720

atagagaagg agttcaagaa tgactacagg aagctctcca tgcagtgcaa agacttcgta      780

gtaggtgtgc tggacctgtg ccgggactca gaggaggtgg aagccattct gaatggagat      840

ctggaatcgg tggaacccct ggagagacac gggcacaagg cgtcgctgag tcgggtcaaa      900

cttgccatta aatatgaagt caaaaagttt gtggctcacc ccaactgcca acagcagctt      960

ttgaccatct ggtacgagaa cctctcgggc cttcgggagc agaccatcgc tatcaagtgt     1020

ctggtcgtgt tggtcgtggc cttgggcctt ccattcctcg ccatcggcta ctggattgca     1080

ccttgtagca ggctggggaa aattcttcga agccccttca tgaagttcgt ggctcacgct     1140

gcctccttca tcatcttcct gggtctgctt gtgttcaacg cctcagaccg gtttgaaggc     1200

atcaccacgc tgcccaacat caccgttatt gactacccca agcaaatctt cagggtgaag     1260

accacccagt tcacatggac agaaatgcta attatggtct gggttctcgg gatgatgtgg     1320

tctgagtgca aggagctgtg gctggagggg ccccgggagt acatcgtgca gctgtggaac     1380

gtgcttgact tcgggatgct ctccatcttc attgctgcct tcaccgccag gttcctagcg     1440

tttctgcaag ccaccaaagc gcagcagtat gtggacagcc acgtgcagga gagcgacctg     1500

agcgaagtca cactcccacc agaggttcag tatttcacct atgctagaga taaatggctt     1560

ccttctgacc ctcagatcat atcggaaggc ctctatgcca tagctgtggt gctcagcttc     1620

tcccggatcg cgtacattct ccctgcaaac gagagctttg ggcccttgca gatctctctg     1680

gggaggactg tgaaggacat attcaagttc atggttctct tcatcatggt gttcctggct     1740

ttcatgattg gcatgttcat actttactcc tactaccttg gggccaaagt aaaccctgct     1800

tttaccacgg ttgaagaaag tttcaagact ttgttttggt ccatatttgg actctctgaa     1860

gtgacttctg ttgtcctcaa atatgaccac aaattcatag agaacattgg ctatgtcctt     1920

tatggaatat acaatgtaac tatggtggtc gttctgctca acatgctgat tgctatgatt     1980

aacagctcat accaagaaat cgaggatgac agtgatgtag agtggaagtt tgctcgttcc     2040

aaactctggc tatcctactt cgatgatgga aaaacattac ctccaccctt cagtctggtc     2100

cctagtccaa aatcgtttgt ttatttcatc atgaggatca ctaacttttc caaatgcagg     2160

aggagaagac ttcagaagga tctggaactg ggcatgggta actcaaagtc caggttaaac     2220

ctcttcactc agtctaactc gagagttttt gaatcacaca gttttaacag cattctcaat     2280

cagccaacac gatatcagca gataatgaaa agactcataa aacggtatgt tttgaaagca     2340

caagtagaca aagaaaatga tgaggtgaac gaaggtgaac tgaaagaaat caagcaggat     2400

atctccagcc ttcgttacga acttttggaa gataagagcc aagcgacgga ggaactggcc     2460

atcttgattc ataaactcag tgagaaactg aaccccagtg cgctgaggtg tgaatga        2517


<210>  8
<211>  838
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ala Arg Pro Arg Glu Pro Ser Arg Ser Ala Ala Ala Gly Ala Gly 
1               5                   10                  15      

Gly Ala Ser Thr Ala Gly Trp Ser Arg Pro Ala Arg Ala Arg Arg Arg 
            20                  25                  30          

Pro Arg Gly Pro Thr Gln Tyr Gly Asn Ile Pro Val Val Arg Lys Met 
        35                  40                  45              

Leu Glu Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly 
    50                  55                  60                  

Gln Asn Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr 
65                  70                  75                  80  

Glu Leu Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu 
                85                  90                  95      

Leu Leu Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu 
            100                 105                 110         

Gly His Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys 
        115                 120                 125             

Glu Gln Glu Leu Arg Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly 
    130                 135                 140                 

Thr Arg Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys 
145                 150                 155                 160 

His Lys Tyr Glu Val Val His Leu Leu Leu Leu Lys Gly Ala Arg Ile 
                165                 170                 175     

Glu Arg Pro His Asp Tyr Phe Cys Arg Cys Ala Asp Cys Ala Glu Lys 
            180                 185                 190         

Gln Arg Leu Asp Ala Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr 
        195                 200                 205             

Lys Gly Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro 
    210                 215                 220                 

Val Leu Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn 
225                 230                 235                 240 

Ile Glu Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys 
                245                 250                 255     

Lys Asp Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu 
            260                 265                 270         

Val Glu Ala Ile Leu Asn Gly Asp Leu Glu Ser Val Glu Pro Leu Glu 
        275                 280                 285             

Arg His Gly His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys 
    290                 295                 300                 

Tyr Glu Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu 
305                 310                 315                 320 

Leu Thr Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile 
                325                 330                 335     

Ala Ile Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe 
            340                 345                 350         

Leu Ala Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile 
        355                 360                 365             

Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile 
    370                 375                 380                 

Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly 
385                 390                 395                 400 

Ile Thr Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile 
                405                 410                 415     

Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met 
            420                 425                 430         

Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu 
        435                 440                 445             

Glu Gly Pro Arg Glu Tyr Ile Val Gln Leu Trp Asn Val Leu Asp Phe 
    450                 455                 460                 

Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala 
465                 470                 475                 480 

Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser His Val Gln 
                485                 490                 495     

Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Val Gln Tyr Phe 
            500                 505                 510         

Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser 
        515                 520                 525             

Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala 
    530                 535                 540                 

Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu 
545                 550                 555                 560 

Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met 
                565                 570                 575     

Val Phe Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr 
            580                 585                 590         

Leu Gly Ala Lys Val Asn Pro Ala Phe Thr Thr Val Glu Glu Ser Phe 
        595                 600                 605             

Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val 
    610                 615                 620                 

Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu 
625                 630                 635                 640 

Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu 
                645                 650                 655     

Ile Ala Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp 
            660                 665                 670         

Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp 
        675                 680                 685             

Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys 
    690                 695                 700                 

Ser Phe Val Tyr Phe Ile Met Arg Ile Thr Asn Phe Ser Lys Cys Arg 
705                 710                 715                 720 

Arg Arg Arg Leu Gln Lys Asp Leu Glu Leu Gly Met Gly Asn Ser Lys 
                725                 730                 735     

Ser Arg Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val Phe Glu Ser 
            740                 745                 750         

His Ser Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile 
        755                 760                 765             

Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Lys 
    770                 775                 780                 

Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp 
785                 790                 795                 800 

Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr 
                805                 810                 815     

Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys Leu Asn Pro 
            820                 825                 830         

Ser Ala Leu Arg Cys Glu 
        835             


<210>  9
<211>  2427
<212>  DNA
<213>  Cavia porcellus

<400>  9
atgcgggaga agggccggcg ccaggcggtc cggggtccgg ccttcatgtt caacgaccgc       60

ggcaccagcc tcacgccgga ggaggagcgc ttcctcgacg ccgccgagta cggcaacatc      120

ccggtggtgc gcaagatgct ggaggagtcc cggacgctga acgtcaactg cgtggactac      180

atgggccaga acgcgctgca gctggccgtg ggcaacgagc acctggaggt caccgagctg      240

ctgctcaaga aggagaacct ggcgcgcatc ggcgacgcgc tgctgctggc catcagcaag      300

ggctacgtgc gcatcgtgga ggccatcctc aaccaccccg gcttcgcggc cagccggcgc      360

ctcaccctca gcccctgcga gcaggagctg caggacgacg acttctacgc ctacgacgag      420

gacggcacgc gcttctcgcc cgacatcacg cccatcatcc tggccgcgca ctgccagaag      480

tacgaggtgg tgcacatgct gctgctgaag ggcgccagga tcgagcggcc gcacgactac      540

ttctgcaagt gcgcggactg cgccgagaag cagcgccacg actccttcag ccactcgcgc      600

tccaggatca acgcctacaa ggggctggcc agccccgcgt acctgtcgct gtccagcgag      660

gacccggtgc tcacggccct ggagctcagc aacgagctgg ccaagctggc caacatcgag      720

aaggagttca agaacgacta cagaaagctg tccatgcaat gcaaagactt tgtagtgggt      780

gtgctggatc tttgccggga ctcggaagag gtcgaagcca ttctgaatgg agatctggaa      840

tccacagagc ctctggaagt gcacaggcat aaagcttcgc tgagtcgtgt caaacttgcc      900

atcaagtatg aagtaaagaa gtttgtagct caccccaact gccagcagca gcttttgacg      960

atttggtacg aaaacctctc gggcctgcgg gaacagactg tcgccatcaa gtgtctggtg     1020

gtgctggttg tggccttggg ccttccgttt cttgccattg gctattggat cgcaccttgc     1080

agcaggctgg ggaaaatcct gcgaagccct ttcatgaagt tcgtggcgca tgcagcttcg     1140

ttcatcatct tcctgggcct gctcgtgttc aatgcctctg acaggttcga gggcattgcc     1200

acgctgccca acatcaccgt catcgactac cccaagcaga tcttccgggt gaaaaccact     1260

cagttcacct ggacagaaat gctaatcatg gtctgggttc tgggaatgat gtggtctgag     1320

tgtaaggagc tctggctgga gggacctaga gaatacattt tgcagttgtg gaatgtgctt     1380

gacttcggga tgctttccat cttcattgct gctttcacag ccagattcct agccttcctt     1440

caagccacaa aagcccaaca gtatgtggac agttatgtcc aagagagcga cctcagtgaa     1500

gtcactctcc cgccagagat acagtatttc acttatgcta gagataaatg gctcccttct     1560

gacccccaga tcatatctga aggcctctac gccatagctg tcgtgctcag cttctctcgg     1620

atcgcataca tcctccctgc aaacgagagc ttcggcccct tgcagatctc cctgggaagg     1680

actgtgaagg acatattcaa gttcatggtc ctcttcatta tggtgtttct ggcctttatg     1740

attggcatgt tcatacttta ttcttactac cttggggcca aagtaaactc tgcttttacc     1800

actgtagaag aaagtttcaa gactttgttt tggtcaatat ttgggttgtc tgaagtgact     1860

tcagttgtgc ttaaatatga tcacaaattc atagagaaca ttggatacgt tctttatgga     1920

atatacaatg taactatggt ggtcgttttg ctcaacatgc taattgctat gattaatagc     1980

tcatatcaag aaattgagga tgacagtgat gtagaatgga agtttgcacg ttcaaagctc     2040

tggttatcct attttgatga tggaaagact ttacctccac ccttcagcct ggttcccagc     2100

ccaaaatcct ttgtttattt catcatgcgg atcattaact tttccaaatg tagaaggaga     2160

aggctgcaga aagatctgga aatgggaatg ggtaactcaa agtccaggca gataatgaaa     2220

agacttataa agcggtatgt tttgaaagca caagtagaca aagaaaatga tgaagttaat     2280

gaaggtgaat taaaagaaat caagcaagat atctccagcc ttcgttatga acttttggaa     2340

gacaagagcc aagcaactga ggaattagcc gttctgattc ataaactgag tgagaaactg     2400

aatcccagcg tgctgagatg tgaatga                                         2427


<210>  10
<211>  808
<212>  PRT
<213>  Cavia porcellus

<400>  10

Met Arg Glu Lys Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met 
1               5                   10                  15      

Phe Asn Asp Arg Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
            20                  25                  30          

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
        35                  40                  45              

Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn 
    50                  55                  60                  

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
65                  70                  75                  80  

Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu 
                85                  90                  95      

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
            100                 105                 110         

Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys Glu Gln 
        115                 120                 125             

Glu Leu Gln Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
    130                 135                 140                 

Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys 
145                 150                 155                 160 

Tyr Glu Val Val His Met Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
                165                 170                 175     

Pro His Asp Tyr Phe Cys Lys Cys Ala Asp Cys Ala Glu Lys Gln Arg 
            180                 185                 190         

His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly 
        195                 200                 205             

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
    210                 215                 220                 

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu 
225                 230                 235                 240 

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
                245                 250                 255     

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu 
            260                 265                 270         

Ala Ile Leu Asn Gly Asp Leu Glu Ser Thr Glu Pro Leu Glu Val His 
        275                 280                 285             

Arg His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu 
    290                 295                 300                 

Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr 
305                 310                 315                 320 

Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Val Ala Ile 
                325                 330                 335     

Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala 
            340                 345                 350         

Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg 
        355                 360                 365             

Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe 
    370                 375                 380                 

Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Ala 
385                 390                 395                 400 

Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile Phe Arg 
                405                 410                 415     

Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp 
            420                 425                 430         

Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly 
        435                 440                 445             

Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met 
    450                 455                 460                 

Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu 
465                 470                 475                 480 

Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser 
                485                 490                 495     

Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr 
            500                 505                 510         

Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly 
        515                 520                 525             

Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile 
    530                 535                 540                 

Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg 
545                 550                 555                 560 

Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe 
                565                 570                 575     

Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly 
            580                 585                 590         

Ala Lys Val Asn Ser Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr 
        595                 600                 605             

Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu 
    610                 615                 620                 

Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly 
625                 630                 635                 640 

Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala 
                645                 650                 655     

Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu 
            660                 665                 670         

Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly 
        675                 680                 685             

Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe 
    690                 695                 700                 

Val Tyr Phe Ile Met Arg Ile Ile Asn Phe Ser Lys Cys Arg Arg Arg 
705                 710                 715                 720 

Arg Leu Gln Lys Asp Leu Glu Met Gly Met Gly Asn Ser Lys Ser Arg 
                725                 730                 735     

Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val 
            740                 745                 750         

Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys 
        755                 760                 765             

Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln 
    770                 775                 780                 

Ala Thr Glu Glu Leu Ala Val Leu Ile His Lys Leu Ser Glu Lys Leu 
785                 790                 795                 800 

Asn Pro Ser Val Leu Arg Cys Glu 
                805             


<210>  11
<211>  2427
<212>  DNA
<213>  Cavia porcellus

<400>  11
atgcgggaga agggccggcg ccaggcggtc cggggtccgg ccttcatgtt caacgaccgc       60

ggcaccagcc tcacgccgga ggaggagcgc ttcctcgacg ccgccgagta cggcaacatc      120

ccggtggtgc gcaagatgct ggaggagtcc cggacgctga acgtcaactg cgtggactac      180

atgggccaga acgcgctgca gctggccgtg ggcaacgagc acctggaggt caccgagctg      240

ctgctcaaga aggagaacct ggcgcgcatc ggcgacgcgc tgctgctggc catcagcaag      300

ggctacgtgc gcatcgtgga ggccatcctc aaccaccccg gcttcgcggc cagccggcgc      360

ctcaccctca gcccctgcga gcaggagctg caggacgacg acttctacgc ctacgacgag      420

gacggcacgc gcttctcgcc cgacatcacg cccatcatcc tggccgcgca ctgccagaag      480

tacgaggtgg tgcacatgct gctgctgaag ggcgccagga tcgagcggcc gcacgactac      540

ttctgcaagt gcgcggactg cgccgagaag cagcgccacg actccttcag ccactcgcgc      600

tccaggatca acgcctacaa ggggctggcc agccccgcgt acctgtcgct gtccagcgag      660

gacccggtgc tcacggccct ggagctcagc aacgagctgg ccaagctggc caacatcgag      720

aaggagttca agaacgacta cagaaagctg tccatgcaat gcaaagactt tgtagtgggt      780

gtgctggatc tttgccggga ctcggaagag gtcgaagcca ttctgaatgg agatctggaa      840

tccacagagc ctctggaagt gcacaggcat aaagcttcgc tgagtcgtgt caaacttgcc      900

atcaagtatg aagtaaagaa gtttgtagct caccccaact gccagcagca gcttttgacg      960

atttggtacg aaaacctctc gggcctgcgg gaacagactg tcgccatcaa gtgtctggtg     1020

gtgctggttg tggccttggg ccttccgttt cttgccattg gctattggat cgcaccttgc     1080

agcaggctgg ggaaaatcct gcgaagccct ttcatgaagt tcgtggcgca tgcagcttcg     1140

ttcatcatct tcctgggcct gctcgtgttc aatgcctctg acaggttcga gggcattgcc     1200

acgctgccca acatcaccgt catcgactac cccaagcaga tcttccgggt gaaaaccact     1260

cagttcacct ggacagaaat gctaatcatg gtctgggttc tgggaatgat gtggtctgag     1320

tgtaaggagc tctggctgga gggacctaga gaatacattt tgcagttgtg gaatgtgctt     1380

gacttcggga tgctttccat cttcattgct gctttcacag ccagattcct agccttcctt     1440

caagccacaa aagcccaaca gtatgtggac agttatgtcc aagagagcga cctcagtgaa     1500

gtcactctcc cgccagagat acagtatttc acttatgcta gagataaatg gctcccttct     1560

gacccccaga tcatatctga aggcctctac gccatagctg tcgtgctcag cttctctcgg     1620

atcgcataca tcctccctgc aaacgagagc ttcggcccct tgcagatctc cctgggaagg     1680

actgtgaagg acatattcaa gttcatggtc ctcttcatta tggtgtttct ggcctttatg     1740

attggcatgt tcatacttta ttcttactac cttggggcca aagtaaactc tgcttttacc     1800

actgtagaag aaagtttcaa gactttgttt tggtcaatat ttgggttgtc tgaagtgact     1860

tcagttgtgc ttaaatatga tcacaaattc atagagaaca ttggatacgt tctttatgga     1920

atatacaatg taactatggt ggtcgttttg ctcaacatgc taattgctat gattaatagc     1980

tcatatcaag aaattgagga tgacagtgat gtagaatgga agtttgcacg ttcaaagctc     2040

tggttatcct attttgatga tggaaagact ttacctccac ccttcagcct ggttcccagc     2100

ccaaaatcct ttgtttattt catcatgcgg atcattaact tttccaaatg tagaaggaga     2160

aggctgcaga aagatctgga aatgggaatg ggtaactcaa agtccaggca gataatgaaa     2220

agacttataa agcggtatgt tttgaaagca caagtagaca aagaaaatga tgaagttaat     2280

gaaggtgaat taaaagaaat caagcaagat atctccagcc ttcgttatga acttttggaa     2340

gacaagagcc aagcaactga ggaattagcc gttctgattc ataaactgag tgagaaactg     2400

aatcccagcg tgctgagatg tgaatga                                         2427


<210>  12
<211>  836
<212>  PRT
<213>  Cavia porcellus

<400>  12

Met Arg Glu Lys Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met 
1               5                   10                  15      

Phe Asn Asp Arg Gly Thr Ser Leu Thr Pro Glu Glu Glu Arg Phe Leu 
            20                  25                  30          

Asp Ala Ala Glu Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu 
        35                  40                  45              

Glu Ser Arg Thr Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn 
    50                  55                  60                  

Ala Leu Gln Leu Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu 
65                  70                  75                  80  

Leu Leu Lys Lys Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu 
                85                  90                  95      

Ala Ile Ser Lys Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His 
            100                 105                 110         

Pro Gly Phe Ala Ala Ser Arg Arg Leu Thr Leu Ser Pro Cys Glu Gln 
        115                 120                 125             

Glu Leu Gln Asp Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg 
    130                 135                 140                 

Phe Ser Pro Asp Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys 
145                 150                 155                 160 

Tyr Glu Val Val His Met Leu Leu Leu Lys Gly Ala Arg Ile Glu Arg 
                165                 170                 175     

Pro His Asp Tyr Phe Cys Lys Cys Ala Asp Cys Ala Glu Lys Gln Arg 
            180                 185                 190         

His Asp Ser Phe Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly 
        195                 200                 205             

Leu Ala Ser Pro Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu 
    210                 215                 220                 

Thr Ala Leu Glu Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu 
225                 230                 235                 240 

Lys Glu Phe Lys Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp 
                245                 250                 255     

Phe Val Val Gly Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu 
            260                 265                 270         

Ala Ile Leu Asn Gly Asp Leu Glu Ser Thr Glu Pro Leu Glu Val His 
        275                 280                 285             

Arg His Lys Ala Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu 
    290                 295                 300                 

Val Lys Lys Phe Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr 
305                 310                 315                 320 

Ile Trp Tyr Glu Asn Leu Ser Gly Leu Arg Glu Gln Thr Val Ala Ile 
                325                 330                 335     

Lys Cys Leu Val Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala 
            340                 345                 350         

Ile Gly Tyr Trp Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg 
        355                 360                 365             

Ser Pro Phe Met Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe 
    370                 375                 380                 

Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Ala 
385                 390                 395                 400 

Thr Leu Pro Asn Ile Thr Val Ile Asp Tyr Pro Lys Gln Ile Phe Arg 
                405                 410                 415     

Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp 
            420                 425                 430         

Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly 
        435                 440                 445             

Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met 
    450                 455                 460                 

Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu 
465                 470                 475                 480 

Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser 
                485                 490                 495     

Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr 
            500                 505                 510         

Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly 
        515                 520                 525             

Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile 
    530                 535                 540                 

Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg 
545                 550                 555                 560 

Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe 
                565                 570                 575     

Leu Ala Phe Met Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly 
            580                 585                 590         

Ala Lys Val Asn Ser Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr 
        595                 600                 605             

Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu 
    610                 615                 620                 

Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly 
625                 630                 635                 640 

Ile Tyr Asn Val Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala 
                645                 650                 655     

Met Ile Asn Ser Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu 
            660                 665                 670         

Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly 
        675                 680                 685             

Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe 
    690                 695                 700                 

Val Tyr Phe Ile Met Arg Ile Ile Asn Phe Ser Lys Cys Arg Arg Arg 
705                 710                 715                 720 

Arg Leu Gln Lys Asp Leu Glu Met Gly Met Gly Asn Ser Lys Ser Arg 
                725                 730                 735     

Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser 
            740                 745                 750         

Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys 
        755                 760                 765             

Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn 
    770                 775                 780                 

Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser 
785                 790                 795                 800 

Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu 
                805                 810                 815     

Leu Ala Val Leu Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Val 
            820                 825                 830         

Leu Arg Cys Glu 
        835     


<210>  13
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse forward primer

<400>  13
ctaacttttc caaatgcagg aggagaag                                          28


<210>  14
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse reverse primer

<400>  14
tcgcatgata aaggtaggga acactaga                                          28


<210>  15
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat forward primer

<400>  15
cagtgatgta gagtggaagt ttgc                                              24


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rat reverse primer

<400>  16
ctccctcatt cacacctcag c                                                 21


<210>  17
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guinea pig forward primer

<400>  17
ggatcattaa cttttccaaa tgtagaagg                                         29


<210>  18
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Guinea pig reverse primer

<400>  18
tctcagcacg ctgggattca gtttct                                            26


<210>  19
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRPC forward primer

<400>  19
acagaattcc tgcggggatg cgtgaca                                           27


<210>  20
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRPC reverse primer

<400>  20
agcggatccc ctcactcaca tctcagca                                          28


<210>  21
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  21
atggagggaa gcccatccct gagacgcatg acagtgatgc gggagaaggg ccggcgccag       60

gctgtcaggg gcccggcctt catgttcaat gaccgcggca ccagcctcac cgccgaggag      120

gagcgcttcc tcgacgccgc cgagtacggc aacatcccag tggtgcgcaa gatgctggag      180

gagtccaaga cgctgaacgt caactgcgtg gactacatgg gccagaacgc gctgcagctg      240

gctgtgggca acgagcacct ggaggtgacc gagctgctgc tcaagaagga gaacctggcg      300

cgcattggcg acgccctgct gctcgccatc agcaagggct acgtgcgcat cgtagaggcc      360

atcctcaacc accctggctt cgcggccagc aagcgtctca ctctgagccc ctgtgagcag      420

gagctgcagg acgacgactt ctacgcttac gacgaggacg gcacgcgctt ctcgccggac      480

atcaccccca tcatcctggc ggcgcactgc cagaaatacg aagtggtgca catgctgctg      540

atgaagggtg ccaggatcga gcggccgcac gactatttct gcaagtgcgg ggactgcatg      600

gagaagcaga ggcacgactc cttcagccac tcacgctcga ggatcaatgc ctacaagggg      660

ctggccagcc cggcttacct ctcattgtcc agcgaggacc cggtgcttac ggccctagag      720

ctcagcaacg agctggccaa gctggccaac atagagaagg agttcaagaa tgactatcgg      780

aagctctcca tgcaatgcaa agactttgta gtgggtgtgc tggatctctg ccgagactca      840

gaagaggtag aagccattct gaatggagat ctggaatcag cagagcctct ggaggtacac      900

aggcacaaag cttcattaag tcgtgtcaaa cttgccatta agtatgaagt caaaaagctg      960

gggaaaattc tgcgaagccc ttttatgaag tttgtagcac atgcagcttc tttcatcatc     1020

ttcctgggtc tgcttgtgtt caatgcctca gacaggttcg aaggcatcac cacgctgccc     1080

aatatcacag ttactgacta tcccaaacag atcttcaggg tgaaaaccac ccagtttaca     1140

tggactgaaa tgctaattat ggtctgggtt cttggaatga tgtggtctga atgtaaagag     1200

ctttggctgg aaggacctag ggaatacatt ttgcagttgt ggaatgtgct tgactttggg     1260

atgctgtcca tcttcattgc tgctttcaca gccagattcc tagctttcct tcaggcaacg     1320

aaggcacaac agtatgtgga cagttacgtc caagagagtg acctcagtga agtgacactc     1380

ccaccagaga tacagtattt cacttatgct agagataaat ggctcccttc tgaccctcag     1440

atattatctg aaggccttta tgccatagct gttgtgctca gcttctctcg gattgcgtac     1500

atcctccctg caaatgagag ctttggcccc ctgcagatct ctcttggaag gactgtaaag     1560

gacatattca agttcatggt cctctttatt atggtgtttt ttgcctttat gattggcatg     1620

ttcatacttt attcttacta ccttggggct aaagttaatg ctgcttttac cactgtagaa     1680

gaaagtttca agactttatt ttggtcaata tttgggttgt ctgaagtgac ttccgttgtg     1740

ctcaaatatg atcacaaatt catagaaaat attggatacg ttctttatgg aatatacaat     1800

gtaactatgg tggtcgtttt actcaacatg ctaattgcta tgattaatag ctcatgccaa     1860

gaaattgagg atgacagtga tgtagaatgg aagtttgctc gttcaaaact ttggttatcc     1920

tattttgatg atggaaaaac attacctcca cctttcagtc tagttcctag tccaaaatca     1980

tttgtttatt tcatcatgcg aattgttaac tttcccaaat gcagaaggag aagacttcag     2040

aaggatatag aaatgggaat gggtaactca aagtccaggt taaacctctt cactcagtct     2100

aactcaagag tttttgaatc acacagtttt aacagcattc tcaatcagcc aacacgttat     2160

cagcagataa tgaaaagact tataaagcgg tatgttttga aagcacaagt agacaaagaa     2220

aatgatgaag ttaatgaagg tgaattaaaa gaaatcaagc aagatatctc cagccttcgt     2280

tatgaacttt tggaagacaa gagccaagca actgaggaat tagccattct aattcataaa     2340

cttagtgaga aactgaatcc cagcatgctg agatgtgaat ga                        2382


<210>  22
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      

Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          

Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              

Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  

Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  

Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      

Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         

Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             

Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 

Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 

Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     

His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         

Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             

Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 

Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 

Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     

Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         

Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             

Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 

Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Leu 
305                 310                 315                 320 

Gly Lys Ile Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala 
                325                 330                 335     

Ser Phe Ile Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg 
            340                 345                 350         

Phe Glu Gly Ile Thr Thr Leu Pro Asn Ile Thr Val Thr Asp Tyr Pro 
        355                 360                 365             

Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met 
    370                 375                 380                 

Leu Ile Met Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu 
385                 390                 395                 400 

Leu Trp Leu Glu Gly Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val 
                405                 410                 415     

Leu Asp Phe Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg 
            420                 425                 430         

Phe Leu Ala Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser 
        435                 440                 445             

Tyr Val Gln Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile 
    450                 455                 460                 

Gln Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln 
465                 470                 475                 480 

Ile Leu Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
                485                 490                 495     

Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
            500                 505                 510         

Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu 
        515                 520                 525             

Phe Ile Met Val Phe Phe Ala Phe Met Ile Gly Met Phe Ile Leu Tyr 
    530                 535                 540                 

Ser Tyr Tyr Leu Gly Ala Lys Val Asn Ala Ala Phe Thr Thr Val Glu 
545                 550                 555                 560 

Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val 
                565                 570                 575     

Thr Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly 
            580                 585                 590         

Tyr Val Leu Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu 
        595                 600                 605             

Asn Met Leu Ile Ala Met Ile Asn Ser Ser Cys Gln Glu Ile Glu Asp 
    610                 615                 620                 

Asp Ser Asp Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser 
625                 630                 635                 640 

Tyr Phe Asp Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro 
                645                 650                 655     

Ser Pro Lys Ser Phe Val Tyr Phe Ile Met Arg Ile Val Asn Phe Pro 
            660                 665                 670         

Lys Cys Arg Arg Arg Arg Leu Gln Lys Asp Ile Glu Met Gly Met Gly 
        675                 680                 685             

Asn Ser Lys Ser Arg Leu Asn Leu Phe Thr Gln Ser Asn Ser Arg Val 
    690                 695                 700                 

Phe Glu Ser His Ser Phe Asn Ser Ile Leu Asn Gln Pro Thr Arg Tyr 
705                 710                 715                 720 

Gln Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln 
                725                 730                 735     

Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile 
            740                 745                 750         

Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser 
        755                 760                 765             

Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys 
    770                 775                 780                 

Leu Asn Pro Ser Met Leu Arg Cys Glu 
785                 790             

<210>  23
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      

Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          

Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              

Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  

Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  

Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      

Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         

Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             

Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 

Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 

Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     

His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         

Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             

Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 

Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 

Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     

Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         

Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             

Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 

Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Leu 
305                 310                 315                 320 

Gly Lys Ile Leu Arg Ser Pro Phe Met Lys Phe Val Ala His Ala Ala 
                325                 330                 335     

Ser Phe Ile Ile Phe Leu Gly Leu Leu Val Phe Asn Ala Ser Asp Arg 
            340                 345                 350         

Phe Glu Gly Ile Thr Thr Leu Pro Asn Ile Thr Val Thr Asp Tyr Pro 
        355                 360                 365             

Lys Gln Ile Phe Arg Val Lys Thr Thr Gln Phe Thr Trp Thr Glu Met 
    370                 375                 380                 

Leu Ile Met Val Trp Val Leu Gly Met Met Trp Ser Glu Cys Lys Glu 
385                 390                 395                 400 

Leu Trp Leu Glu Gly Pro Arg Glu Tyr Ile Leu Gln Leu Trp Asn Val 
                405                 410                 415     

Leu Asp Phe Gly Met Leu Ser Ile Phe Ile Ala Ala Phe Thr Ala Arg 
            420                 425                 430         

Phe Leu Ala Phe Leu Gln Ala Thr Lys Ala Gln Gln Tyr Val Asp Ser 
        435                 440                 445             

Tyr Val Gln Glu Ser Asp Leu Ser Glu Val Thr Leu Pro Pro Glu Ile 
    450                 455                 460                 

Gln Tyr Phe Thr Tyr Ala Arg Asp Lys Trp Leu Pro Ser Asp Pro Gln 
465                 470                 475                 480 

Ile Leu Ser Glu Gly Leu Tyr Ala Ile Ala Val Val Leu Ser Phe Ser 
                485                 490                 495     

Arg Ile Ala Tyr Ile Leu Pro Ala Asn Glu Ser Phe Gly Pro Leu Gln 
            500                 505                 510         

Ile Ser Leu Gly Arg Thr Val Lys Asp Ile Phe Lys Phe Met Val Leu 
        515                 520                 525             

Phe Ile Met Val Phe Phe Ala Phe Met Ile Gly Met Phe Ile Leu Tyr 
    530                 535                 540                 

Ser Tyr Tyr Leu Gly Ala Lys Val Asn Ala Ala Phe Thr Thr Val Glu 
545                 550                 555                 560 

Glu Ser Phe Lys Thr Leu Phe Trp Ser Ile Phe Gly Leu Ser Glu Val 
                565                 570                 575     

Thr Ser Val Val Leu Lys Tyr Asp His Lys Phe Ile Glu Asn Ile Gly 
            580                 585                 590         

Tyr Val Leu Tyr Gly Ile Tyr Asn Val Thr Met Val Val Val Leu Leu 
        595                 600                 605             

Asn Met Leu Ile Ala Met Ile Asn Ser Ser Cys Gln Glu Ile Glu Asp 
    610                 615                 620                 

Asp Ser Asp Val Glu Trp Lys Phe Ala Arg Ser Lys Leu Trp Leu Ser 
625                 630                 635                 640 

Tyr Phe Asp Asp Gly Lys Thr Leu Pro Pro Pro Phe Ser Leu Val Pro 
                645                 650                 655     

Ser Pro Lys Ser Phe Val Tyr Phe Ile Met Arg Ile Val Asn Phe Pro 
            660                 665                 670         

Lys Cys Arg Arg Arg Arg Leu Gln Lys Asp Ile Glu Met Gly Met Gly 
        675                 680                 685             

Asn Ser Lys Ser Arg Gln Ile Met Lys Arg Leu Ile Lys Arg Tyr Val 
    690                 695                 700                 

Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn Glu Gly Glu 
705                 710                 715                 720 

Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr Glu Leu Leu 
                725                 730                 735     

Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu Ile His Lys 
            740                 745                 750         

Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        755                 760                 765 


<210>  24
<211>  2547
<212>  DNA
<213>  Homo sapiens

<400>  24
atggagggaa gcccatccct gagacgcatg acagtgatgc gggagaaggg ccggcgccag       60

gctgtcaggg gcccggcctt catgttcaat gaccgcggca ccagcctcac cgccgaggag      120

gagcgcttcc tcgacgccgc cgagtacggc aacatcccag tggtgcgcaa gatgctggag      180

gagtccaaga cgctgaacgt caactgcgtg gactacatgg gccagaacgc gctgcagctg      240

gctgtgggca acgagcacct ggaggtgacc gagctgctgc tcaagaagga gaacctggcg      300

cgcattggcg acgccctgct gctcgccatc agcaagggct acgtgcgcat cgtagaggcc      360

atcctcaacc accctggctt cgcggccagc aagcgtctca ctctgagccc ctgtgagcag      420

gagctgcagg acgacgactt ctacgcttac gacgaggacg gcacgcgctt ctcgccggac      480

atcaccccca tcatcctggc ggcgcactgc cagaaatacg aagtggtgca catgctgctg      540

atgaagggtg ccaggatcga gcggccgcac gactatttct gcaagtgcgg ggactgcatg      600

gagaagcaga ggcacgactc cttcagccac tcacgctcga ggatcaatgc ctacaagggg      660

ctggccagcc cggcttacct ctcattgtcc agcgaggacc cggtgcttac ggccctagag      720

ctcagcaacg agctggccaa gctggccaac atagagaagg agttcaagaa tgactatcgg      780

aagctctcca tgcaatgcaa agactttgta gtgggtgtgc tggatctctg ccgagactca      840

gaagaggtag aagccattct gaatggagat ctggaatcag cagagcctct ggaggtacac      900

aggcacaaag cttcattaag tcgtgtcaaa cttgccatta agtatgaagt caaaaagttt      960

gtggctcatc ccaactgcca gcagcagctc ttgacgatct ggtatgagaa cctctcaggc     1020

ctaagggagc agaccatagc tatcaagtgt ctcgttgtgc tggtcgtggc cctgggcctt     1080

ccattcctgg ccattggcta ctggatcgca ccttgcagca ggctggggaa aattctgcga     1140

agccctttta tgaagtttgt agcacatgca gcttctttca tcatcttcct gggtctgctt     1200

gtgttcaatg cctcagacag gttcgaaggc atcaccacgc tgcccaatat cacagttact     1260

gactatccca aacagatctt cagggtgaaa accacccagt ttacatggac tgaaatgcta     1320

attatggtct gggttcttgg aatgatgtgg tctgaatgta aagagctctg gctggaagga     1380

cctagggaat acattttgca gttgtggaat gtgcttgact ttgggatgct gtccatcttc     1440

attgctgctt tcacagccag attcctagct ttccttcagg caacgaaggc acaacagtat     1500

gtggacagtt acgtccaaga gagtgacctc agtgaagtga cactcccacc agagatacag     1560

tatttcactt atgctagaga taaatggctc ccttctgacc ctcagattat atctgaaggc     1620

ctttatgcca tagctgttgt gctcagcttc tctcggattg cgtacatcct ccctgcaaat     1680

gagagctttg gccccctgca gatctctctt ggaaggactg taaaggacat attcaagttc     1740

atggtcctct ttattatggt gttttttgcc tttatgattg gcatgttcat actttattct     1800

tactaccttg gggctaaagt taatgctgct tttaccactg tagaagaaag tttcaagact     1860

ttattttggt caatatttgg gttgtctgaa gtgacttccg ttgtgctcaa atatgatcac     1920

aaattcatag aaaatattgg atacgttctt tatggaatat acaatgtaac tatggtggtc     1980

gttttactca acatgctaat tgctatgatt aatagctcat atcaagaaat tgaggatgac     2040

agtgatgtag aatggaagtt tgctcgttca aaactttggt tatcctattt tgatgatgga     2100

aaaacattac ctccaccttt cagtctagtt cctagtccaa aatcatttgt ttatttcatc     2160

atgcgaattg ttaactttcc caaatgcaga aggagaaggc ttcagaagga tatagaaatg     2220

ggaatgggta actcaaagtc caggttaaac ctcttcactc agtctaactc aagagttttt     2280

gaatcacaca gttttaacag cattctcaat cagccaacac gttatcagca gataatgaaa     2340

agacttataa agcggtatgt tttgaaagca caagtagaca aagaaaatga tgaagttaat     2400

gaaggtgaat taaaagaaat caagcaagat atctccagcc ttcgttatga acttttggaa     2460

gacaagagcc aagcaactga ggaattagcc attctaattc ataaacttag tgagaaactg     2520

aatcccagca tgctgagatg tgaatga                                         2547


<210>  25
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      

Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          

Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              

Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  

Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  

Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      

Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         

Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             

Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 

Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 

Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     

His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         

Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             

Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 

Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 

Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     

Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         

Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             

Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 

Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 

Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     

Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         

Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             

Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 

Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 

Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     

Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         

Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             

Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 

Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 

Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     

Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         

Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             

Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 

Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 

Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     

Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         

Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             

Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 

Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 

Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     

Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         

Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             

Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 

Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 

Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     

Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Leu Asn Leu Phe 
            740                 745                 750         

Thr Gln Ser Asn Ser Arg Val Phe Glu Ser His Ser Phe Asn Ser Ile 
        755                 760                 765             

Leu Asn Gln Pro Thr Arg Tyr Gln Gln Ile Met Lys Arg Leu Ile Lys 
    770                 775                 780                 

Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn Asp Glu Val Asn 
785                 790                 795                 800 

Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser Ser Leu Arg Tyr 
                805                 810                 815     

Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu Leu Ala Ile Leu 
            820                 825                 830         

Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met Leu Arg Cys Glu 
        835                 840                 845             


<210>  26
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Gly Ser Pro Ser Leu Arg Arg Met Thr Val Met Arg Glu Lys 
1               5                   10                  15      


Gly Arg Arg Gln Ala Val Arg Gly Pro Ala Phe Met Phe Asn Asp Arg 
            20                  25                  30          

Gly Thr Ser Leu Thr Ala Glu Glu Glu Arg Phe Leu Asp Ala Ala Glu 
        35                  40                  45              

Tyr Gly Asn Ile Pro Val Val Arg Lys Met Leu Glu Glu Ser Lys Thr 
    50                  55                  60                  

Leu Asn Val Asn Cys Val Asp Tyr Met Gly Gln Asn Ala Leu Gln Leu 
65                  70                  75                  80  

Ala Val Gly Asn Glu His Leu Glu Val Thr Glu Leu Leu Leu Lys Lys 
                85                  90                  95      

Glu Asn Leu Ala Arg Ile Gly Asp Ala Leu Leu Leu Ala Ile Ser Lys 
            100                 105                 110         

Gly Tyr Val Arg Ile Val Glu Ala Ile Leu Asn His Pro Gly Phe Ala 
        115                 120                 125             

Ala Ser Lys Arg Leu Thr Leu Ser Pro Cys Glu Gln Glu Leu Gln Asp 
    130                 135                 140                 

Asp Asp Phe Tyr Ala Tyr Asp Glu Asp Gly Thr Arg Phe Ser Pro Asp 
145                 150                 155                 160 

Ile Thr Pro Ile Ile Leu Ala Ala His Cys Gln Lys Tyr Glu Val Val 
                165                 170                 175     

His Met Leu Leu Met Lys Gly Ala Arg Ile Glu Arg Pro His Asp Tyr 
            180                 185                 190         

Phe Cys Lys Cys Gly Asp Cys Met Glu Lys Gln Arg His Asp Ser Phe 
        195                 200                 205             

Ser His Ser Arg Ser Arg Ile Asn Ala Tyr Lys Gly Leu Ala Ser Pro 
    210                 215                 220                 

Ala Tyr Leu Ser Leu Ser Ser Glu Asp Pro Val Leu Thr Ala Leu Glu 
225                 230                 235                 240 

Leu Ser Asn Glu Leu Ala Lys Leu Ala Asn Ile Glu Lys Glu Phe Lys 
                245                 250                 255     

Asn Asp Tyr Arg Lys Leu Ser Met Gln Cys Lys Asp Phe Val Val Gly 
            260                 265                 270         

Val Leu Asp Leu Cys Arg Asp Ser Glu Glu Val Glu Ala Ile Leu Asn 
        275                 280                 285             

Gly Asp Leu Glu Ser Ala Glu Pro Leu Glu Val His Arg His Lys Ala 
    290                 295                 300                 

Ser Leu Ser Arg Val Lys Leu Ala Ile Lys Tyr Glu Val Lys Lys Phe 
305                 310                 315                 320 

Val Ala His Pro Asn Cys Gln Gln Gln Leu Leu Thr Ile Trp Tyr Glu 
                325                 330                 335     

Asn Leu Ser Gly Leu Arg Glu Gln Thr Ile Ala Ile Lys Cys Leu Val 
            340                 345                 350         

Val Leu Val Val Ala Leu Gly Leu Pro Phe Leu Ala Ile Gly Tyr Trp 
        355                 360                 365             

Ile Ala Pro Cys Ser Arg Leu Gly Lys Ile Leu Arg Ser Pro Phe Met 
    370                 375                 380                 

Lys Phe Val Ala His Ala Ala Ser Phe Ile Ile Phe Leu Gly Leu Leu 
385                 390                 395                 400 

Val Phe Asn Ala Ser Asp Arg Phe Glu Gly Ile Thr Thr Leu Pro Asn 
                405                 410                 415     

Ile Thr Val Thr Asp Tyr Pro Lys Gln Ile Phe Arg Val Lys Thr Thr 
            420                 425                 430         

Gln Phe Thr Trp Thr Glu Met Leu Ile Met Val Trp Val Leu Gly Met 
        435                 440                 445             

Met Trp Ser Glu Cys Lys Glu Leu Trp Leu Glu Gly Pro Arg Glu Tyr 
    450                 455                 460                 

Ile Leu Gln Leu Trp Asn Val Leu Asp Phe Gly Met Leu Ser Ile Phe 
465                 470                 475                 480 

Ile Ala Ala Phe Thr Ala Arg Phe Leu Ala Phe Leu Gln Ala Thr Lys 
                485                 490                 495     

Ala Gln Gln Tyr Val Asp Ser Tyr Val Gln Glu Ser Asp Leu Ser Glu 
            500                 505                 510         

Val Thr Leu Pro Pro Glu Ile Gln Tyr Phe Thr Tyr Ala Arg Asp Lys 
        515                 520                 525             

Trp Leu Pro Ser Asp Pro Gln Ile Ile Ser Glu Gly Leu Tyr Ala Ile 
    530                 535                 540                 

Ala Val Val Leu Ser Phe Ser Arg Ile Ala Tyr Ile Leu Pro Ala Asn 
545                 550                 555                 560 

Glu Ser Phe Gly Pro Leu Gln Ile Ser Leu Gly Arg Thr Val Lys Asp 
                565                 570                 575     

Ile Phe Lys Phe Met Val Leu Phe Ile Met Val Phe Phe Ala Phe Met 
            580                 585                 590         

Ile Gly Met Phe Ile Leu Tyr Ser Tyr Tyr Leu Gly Ala Lys Val Asn 
        595                 600                 605             

Ala Ala Phe Thr Thr Val Glu Glu Ser Phe Lys Thr Leu Phe Trp Ser 
    610                 615                 620                 

Ile Phe Gly Leu Ser Glu Val Thr Ser Val Val Leu Lys Tyr Asp His 
625                 630                 635                 640 

Lys Phe Ile Glu Asn Ile Gly Tyr Val Leu Tyr Gly Ile Tyr Asn Val 
                645                 650                 655     

Thr Met Val Val Val Leu Leu Asn Met Leu Ile Ala Met Ile Asn Ser 
            660                 665                 670         

Ser Tyr Gln Glu Ile Glu Asp Asp Ser Asp Val Glu Trp Lys Phe Ala 
        675                 680                 685             

Arg Ser Lys Leu Trp Leu Ser Tyr Phe Asp Asp Gly Lys Thr Leu Pro 
    690                 695                 700                 

Pro Pro Phe Ser Leu Val Pro Ser Pro Lys Ser Phe Val Tyr Phe Ile 
705                 710                 715                 720 

Met Arg Ile Val Asn Phe Pro Lys Cys Arg Arg Arg Arg Leu Gln Lys 
                725                 730                 735     

Asp Ile Glu Met Gly Met Gly Asn Ser Lys Ser Arg Gln Ile Met Lys 
            740                 745                 750         

Arg Leu Ile Lys Arg Tyr Val Leu Lys Ala Gln Val Asp Lys Glu Asn 
        755                 760                 765             

Asp Glu Val Asn Glu Gly Glu Leu Lys Glu Ile Lys Gln Asp Ile Ser 
    770                 775                 780                 

Ser Leu Arg Tyr Glu Leu Leu Glu Asp Lys Ser Gln Ala Thr Glu Glu 
785                 790                 795                 800 

Leu Ala Ile Leu Ile His Lys Leu Ser Glu Lys Leu Asn Pro Ser Met 
                805                 810                 815     

Leu Arg Cys Glu 
            820 







 1/43 



