               SEQUENCE LISTING

<110> Friedrich Miescher Institute for Biomedical Research

<120> New treatment for neurodegenerative diseases

<130> 55105

<160> 19

<170> BiSSAP 1.0

<210> 1
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 1
gtacaatgtg gctcacagaa                                                20


<210> 2
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 2
caggcacagg aatatgagtt                                                20


<210> 3
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 3
caactctgcc tctcctggat                                                20


<210> 4
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 4
ccgtcgacca attctcatgt                                                20


<210> 5
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 5
cgcaagatgt ggcgtgttac                                                20


<210> 6
<211> 19
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..19
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 6
gggaagctgt tgtcccaag                                                 19


<210> 7
<211> 26
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..26
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 7
ctgcatctgg ttcttgcaaa acacca                                         26


<210> 8
<211> 21
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 8
caaggggagg taaaagagag c                                              21


<210> 9
<211> 21
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 9
caaggggagg taaaagagag c                                              21


<210> 10
<211> 22
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..22
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 10
ccaatggtcg ggcactgctc aa                                             22


<210> 11
<211> 22
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..22
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 11
tcaccagtca tttctgcctt tg                                             22


<210> 12
<211> 21
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 12
tggtttgcgt cgtagtctcc t                                              21


<210> 13
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 13
aatgcttccc cacaccttca                                                20


<210> 14
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 14
aatgcttccc cacaccttca                                                20


<210> 15
<211> 20
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 15
cacaactggt tcaccgcttg                                                20


<210> 16
<211> 22
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..22
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 16
ccttgagatc aacacgtacc ag                                             22


<210> 17
<211> 19
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..19
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 17
cgcctgtaca ctccaccac                                                 19


<210> 18
<211> 4099
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4099
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 18
gggcagtccc ctgaggagcg gggctggttg aaacgctagg ggcgggatct ggcggagtgg       60

aagaaccgcg gcaggggcca agcctcctca actatgacct caaccggcca ggattccacc      120

acaaccaggc agcgaagaag taggcagaac ccccagtcgc cccctcagga ctccagtgtc      180

acttcgaagc gaaatattaa aaagggagcc gttccccgct ctatccccaa tctagcggag      240

gtaaagaaga aaggcaaaat gaagaagctc ggccaagcaa tggaagaaga cctaatcgtg      300

ggactgcaag ggatggatct gaaccttgag gctgaagcac tggctggcac tggcttggtg      360

ttggatgagc agttaaatga attccattgc ctctgggatg acagcttccc ggaaggccct      420

gagcggctcc atgccatcaa ggagcaactg atccaggagg gcctcctaga tcgctgcgtg      480

tcctttcagg cccggtttgc tgaaaaggaa gagctgatgt tggttcacag cctagaatat      540

attgatctga tggaaacaac ccagtacatg aatgagggag aactccgtgt cctagcagac      600

acctacgact cagtttatct gcatccgaac tcatactcct gtgcctgcct ggcctcaggc      660

tctgtcctca ggctggtgga tgcggtcctg ggggctgaga tccggaatgg catggccatc      720

attaggcctc ctggacatca cgcccagcac agtcttatgg atggctattg catgttcaac      780

cacgtggctg tggcagcccg ctatgctcaa cagaaacacc gcatccggag ggtccttatc      840

gtagattggg atgtgcacca cggtcaagga acacagttca ccttcgacca ggaccccagt      900

gtcctctatt tctccatcca ccgctacgag cagggtaggt tctggcccca cctgaaggcc      960

tctaactggt ccaccacagg tttcggccaa ggccaaggat ataccatcaa tgtgccttgg     1020

aaccaggtgg ggatgcggga tgctgactac attgctgctt tcctgcacgt cctgctgcca     1080

gtcgccctcg agttccagcc tcagctggtc ctggtggctg ctggatttga tgccctgcaa     1140

ggggacccca agggtgagat ggccgccact ccggcagggt tcgcccagct aacccacctg     1200

ctcatgggtc tggcaggagg caagctgatc ctgtctctgg agggtggcta caacctccgc     1260

gccctggctg aaggcgtcag tgcttcgctc cacacccttc tgggagaccc ttgccccatg     1320

ctggagtcac ctggtgcccc ctgccggagt gcccaggctt cagtttcctg tgctctggaa     1380

gcccttgagc ccttctggga ggttcttgtg agatcaactg agaccgtgga gagggacaac     1440

atggaggagg acaatgtaga ggagagcgag gaggaaggac cctgggagcc ccctgtgctc     1500

ccaatcctga catggccagt gctacagtct cgcacagggc tggtctatga ccaaaatatg     1560

atgaatcact gcaacttgtg ggacagccac caccctgagg taccccagcg catcttgcgg     1620

atcatgtgcc gtctggagga gctgggcctt gccgggcgct gcctcaccct gacaccgcgc     1680

cctgccacag aggctgagct gctcacctgt cacagtgctg agtacgtggg tcatctccgg     1740

gccacagaga aaatgaaaac ccgggagctg caccgtgaga gttccaactt tgactccatc     1800

tatatctgcc ccagtacctt cgcctgtgca cagcttgcca ctggcgctgc ctgccgcctg     1860

gtggaggctg tgctctcagg agaggttctg aatggtgctg ctgtggtgcg tcccccagga     1920

caccacgcag agcaggatgc agcttgcggt ttttgctttt tcaactctgt ggctgtggct     1980

gctcgccatg cccagactat cagtgggcat gccctacgga tcctgattgt ggattgggat     2040

gtccaccacg gtaatggaac tcagcacatg tttgaggatg accccagtgt gctatatgtg     2100

tccctgcacc gctatgatca tggcaccttc ttccccatgg gggatgaggg tgccagcagc     2160

cagatcggcc gggctgcggg cacaggcttc accgtcaacg tggcatggaa cgggccccgc     2220

atgggtgatg ctgactacct agctgcctgg catcgcctgg tgcttcccat tgcctacgag     2280

tttaacccag aactggtgct ggtctcagct ggctttgatg ctgcacgggg ggatccgctg     2340

gggggctgcc aggtgtcacc tgagggttat gcccacctca cccacctgct gatgggcctt     2400

gccagtggcc gcattatcct tatcctagag ggtggctata acctgacatc catctcagag     2460

tccatggctg cctgcactcg ctccctcctt ggagacccac cacccctgct gaccctgcca     2520

cggcccccac tatcaggggc cctggcctca atcactgaga ccatccaagt ccatcgcaga     2580

tactggcgca gcttacgggt catgaaggta gaagacagag aaggaccctc cagttctaag     2640

ttggtcacca agaaggcacc ccaaccagcc aaacctaggt tagctgagcg gatgaccaca     2700

cgagaaaaga aggttctgga agcaggcatg gggaaagtca cctcggcatc atttggggaa     2760

gagtccactc caggccagac taactcagag acagctgtgg tggccctcac tcaggaccag     2820

ccctcagagg cagccacagg gggagccact ctggcccaga ccatttctga ggcagccatt     2880

gggggagcca tgctgggcca gaccacctca gaggaggctg tcgggggagc cactccggac     2940

cagaccacct cagaggagac tgtgggagga gccattctgg accagaccac ctcagaggat     3000

gctgttgggg gagccacgct gggccagact acctcagagg aggctgtagg aggagctaca     3060

ctggcccaga ccatctcgga ggcagccatg gagggagcca cactggacca gactacgtca     3120

gaggaggctc cagggggcac cgagctgatc caaactcctc tagcctcgag cacagaccac     3180

cagacccccc caacctcacc tgtgcaggga actacacccc agatatctcc cagtacactg     3240

attgggagtc tcaggacctt ggagctaggc agcgaatctc agggggcctc agaatctcag     3300

gccccaggag aggagaacct actaggagag gcagctggag gtcaggacat ggctgattcg     3360

atgctgatgc agggatctag gggcctcact gatcaggcca tattttatgc tgtgacacca     3420

ctgccctggt gtccccattt ggtggcagta tgccccatac ctgcagcagg cctagacgtg     3480

acccaacctt gtggggactg tggaacaatc caagagaatt gggtgtgtct ctcttgctat     3540

caggtctact gtggtcgtta catcaatggc cacatgctcc aacaccatgg aaattctgga     3600

cacccgctgg tcctcagcta catcgacctg tcagcctggt gttactactg tcaggcctat     3660

gtccaccacc aggctctcct agatgtgaag aacatcgccc accagaacaa gtttggggag     3720

gatatgcccc acccacacta agccccagaa tacggtccct cttcaccttc tgaggcccac     3780

gatagaccag ctgtagctca ttccagcctg taccttggat gaggggtagc ctcccactgc     3840

atcccatcct gaatatcctt tgcaactccc caagagtgct tatttaagtg ttaatacttt     3900

taagagaact gcgacgatta attgtggatc tccccctgcc cattgcctgc ttgaggggca     3960

ccactactcc agcccagaag gaaagggggg cagctcagtg gccccaagag ggagctgata     4020

tcatgaggat aacattggcg ggaggggagt taactggcag gcatggcaag gttgcatatg     4080

taataaagta caagctgtt                                                  4099


<210> 19
<211> 1215
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1215
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 19
Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser 
1               5                   10                   15    
Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys 
            20                   25                  30        
Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala 
        35                   40                  45            
Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu 
    50                   55                  60                
Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala 
65                   70                  75                  80
Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu 
                85                   90                  95    
Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu 
            100                  105                110        
His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys 
        115                  120                125            
Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val 
    130                  135                140                
His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn 
145                  150                155                  160
Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu 
                165                  170                175    
His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu 
            180                  185                190        
Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala 
        195                  200                205            
Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly 
    210                  215                220                
Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln 
225                  230                235                  240
Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His 
                245                  250                255    
Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr 
            260                  265                270        
Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys 
        275                  280                285            
Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr 
    290                  295                300                
Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile 
305                  310                315                  320
Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro 
                325                  330                335    
Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro 
            340                  345                350        
Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His 
        355                  360                365            
Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly 
    370                  375                380                
Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His 
385                  390                395                  400
Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro 
                405                  410                415    
Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu 
            420                  425                430        
Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp 
        435                  440                445            
Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp 
    450                  455                460                
Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg 
465                  470                475                  480
Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp 
                485                  490                495    
Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys 
            500                  505                510        
Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro 
        515                  520                525            
Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr 
    530                  535                540                
Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His 
545                  550                555                  560
Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe 
                565                  570                575    
Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala 
            580                  585                590        
Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro 
        595                  600                605            
Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn 
    610                  615                620                
Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala 
625                  630                635                  640
Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr 
                645                  650                655    
Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His 
            660                  665                670        
Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser 
        675                  680                685            
Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala 
    690                  695                700                
Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His 
705                  710                715                  720
Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu 
                725                  730                735    
Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys 
            740                  745                750        
Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly 
        755                  760                765            
Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu 
    770                  775                780                
Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly 
785                  790                795                  800
Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala 
                805                  810                815    
Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg 
            820                  825                830        
Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser 
        835                  840                845            
Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala 
    850                  855                860                
Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly 
865                  870                875                  880
Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr 
                885                  890                895    
Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu 
            900                  905                910        
Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala 
        915                  920                925            
Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly 
    930                  935                940                
Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala 
945                  950                955                  960
Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu 
                965                  970                975    
Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln 
            980                  985                990        
Thr Ile Ser Glu Ala Ala Met Glu Gly Ala Thr Leu Asp Gln Thr Thr 
        995                  1000                1005            
Ser Glu Glu Ala Pro Gly Gly Thr Glu Leu Ile Gln Thr Pro Leu Ala 
    1010                1015                1020                
Ser Ser Thr Asp His Gln Thr Pro Pro Thr Ser Pro Val Gln Gly Thr 
1025                1030                1035                1040
Thr Pro Gln Ile Ser Pro Ser Thr Leu Ile Gly Ser Leu Arg Thr Leu 
                1045                1050                1055    
Glu Leu Gly Ser Glu Ser Gln Gly Ala Ser Glu Ser Gln Ala Pro Gly 
            1060                1065                1070        
Glu Glu Asn Leu Leu Gly Glu Ala Ala Gly Gly Gln Asp Met Ala Asp 
        1075                1080                1085            
Ser Met Leu Met Gln Gly Ser Arg Gly Leu Thr Asp Gln Ala Ile Phe 
    1090                1095                1100                
Tyr Ala Val Thr Pro Leu Pro Trp Cys Pro His Leu Val Ala Val Cys 
1105                1110                1115                1120
Pro Ile Pro Ala Ala Gly Leu Asp Val Thr Gln Pro Cys Gly Asp Cys 
                1125                1130                1135    
Gly Thr Ile Gln Glu Asn Trp Val Cys Leu Ser Cys Tyr Gln Val Tyr 
            1140                1145                1150        
Cys Gly Arg Tyr Ile Asn Gly His Met Leu Gln His His Gly Asn Ser 
        1155                1160                1165            
Gly His Pro Leu Val Leu Ser Tyr Ile Asp Leu Ser Ala Trp Cys Tyr 
    1170                1175                1180                
Tyr Cys Gln Ala Tyr Val His His Gln Ala Leu Leu Asp Val Lys Asn 
1185                1190                1195                1200
Ile Ala His Gln Asn Lys Phe Gly Glu Asp Met Pro His Pro His 
                1205                1210                1215

