                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Covalently linked antigen-antibody conjugates

<130>  31087 WO

<150>  EP12174947.7
<151>  2012-07-04

<160>  192   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Asp Tyr Ala Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  2

Ser Ile Asn Ile Gly Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  3

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  4
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Asn Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ile Gly Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Pro Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  6

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  7

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  8
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Val Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Asn Leu Glu Arg 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-H1

<400>  9

Asp Tyr Ala Met Ser 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-H2

<400>  10

Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-H3

<400>  11

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-L1

<400>  13

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-L2

<400>  14

Tyr Ser Ser Thr Leu Leu Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody HVR-L3

<400>  15

Gln Gln Ser Ile Thr Leu Pro Pro Thr 
1               5                   


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VL

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  17
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Tyr Ala Met Ser 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-digoxigenin antibody VH52bC HVR-H2

<400>  18

Ser Ile Asn Ile Cys Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  19

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-digoxigenin antibody VH52bC VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Asn Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ile Cys Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Pro Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  21

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  24
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Val Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Asn Leu Glu Arg 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-H1

<400>  25

Asp Tyr Ala Met Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-H2

<400>  26

Ser Ile Asn Ile Cys Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-H3

<400>  27

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC VH

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Cys Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-L1

<400>  29

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-L2

<400>  30

Tyr Ser Ser Thr Leu Leu Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC HVR-L3

<400>  31

Gln Gln Ser Ile Thr Leu Pro Pro Thr 
1               5                   


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH52bC VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  33

Asp Thr Phe Phe Gln 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  35

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  36
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  36

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ser Ser Gly Phe Asn Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Lys Gln Arg Pro Glu Glu Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  37
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  37

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  38
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  38

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  39
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  39

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  40
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-H1

<400>  41

Asp Thr Phe Phe Gln 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-H2

<400>  42

Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-H3

<400>  43

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Phe Asn Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-L1

<400>  45

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-L2

<400>  46

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody HVR-L3

<400>  47

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VL

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  49

Asp Thr Phe Phe Gln 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-biotin antibody VH53C HVR-H2

<400>  50

Arg Ile Asp Pro Cys Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  51

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  52
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-biotin antibody VH53C VH

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ser Ser Gly Phe Asn Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Lys Gln Arg Pro Glu Glu Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Cys Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  53
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  53

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  54
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  54

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  55

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  56
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-H1

<400>  57

Asp Thr Phe Phe Gln 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-H2

<400>  58

Arg Ile Asp Pro Cys Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-H3

<400>  59

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C VH

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Phe Asn Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Cys Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-L1

<400>  61

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-L2

<400>  62

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C HVR-L3

<400>  63

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH53C VL

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  65

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  66
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  66

Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  67
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  67

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  68
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  68

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Phe Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  69
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  69

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  70
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  70

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  71

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  72
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  72

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Leu Lys Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-H1

<400>  73

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-H2

<400>  74

Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-H3

<400>  75

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  76
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH

<400>  76

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-L1

<400>  77

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-L2

<400>  78

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody HVR-L3

<400>  79

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  80
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VL

<400>  80

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  81
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  81

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-theophylline antibody VH53C HVR-H2

<400>  82

Tyr Ile Arg Cys Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  83
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  83

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  84
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-theophylline antibody VH53C VH

<400>  84

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg Cys Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Phe Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  85
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  85

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  86
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  86

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  87
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  87

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  88
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  88

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Leu Lys Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-H1

<400>  89

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-H2

<400>  90

Tyr Ile Arg Cys Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-H3

<400>  91

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  92
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C VH

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Arg Cys Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-L1

<400>  93

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-L2

<400>  94

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C HVR-L3

<400>  95

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  96
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH53C VL

<400>  96

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  97
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  97

His Tyr Trp Met Asn 
1               5   


<210>  98
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  98

Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  99
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  99

Ala Ser Tyr Gly Met Glu Tyr 
1               5           


<210>  100
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  100

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  101
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  101

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10                  15      


<210>  102
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  102

Lys Val Ser Asn Arg Val Ser 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  103

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  104
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  104

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val 
        115                 120 


<210>  105
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  105

His Tyr Trp Met Asn 
1               5   


<210>  106
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-fluorescein antibody VH53C HVR-H2

<400>  106

Gln Phe Arg Asn Cys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  107
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  107

Ala Ser Tyr Gly Met Glu Tyr 
1               5           


<210>  108
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-fluorescein antibody VH53C VH

<400>  108

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Cys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  109
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  109

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10                  15      


<210>  110
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  110

Lys Val Ser Asn Arg Val Ser 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  111

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  112
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  112

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  113
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  113

His Tyr Trp Met Asn 
1               5   


<210>  114
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  114

Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  115
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  115

Ala Ser Tyr Gly Met Glu Tyr 
1               5           


<210>  116
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-fluorescein antibody VH28C VH

<400>  116

Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Cys Phe Gly His Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  117
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  117

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
1               5                   10                  15      


<210>  118
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  118

Lys Val Ser Asn Arg Val Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  119

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  120
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  120

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  121
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  121

Asp Tyr Ala Met Ser 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  122

Ser Ile Asn Ile Gly Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  123

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  124
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-digoxigenin antibody VH28C VH

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Cys Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Asn Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Ile Gly Ala Thr Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Pro Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  125
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  125

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  126
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  126

Tyr Ser Ser Thr Leu Leu Ser 
1               5           


<210>  127
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  127

Gln Gln Ser Ile Thr Leu Pro Pro Thr 
1               5                   


<210>  128
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  128

Asp Val Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Asn Leu Glu Arg 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-H1

<400>  129

Asp Tyr Ala Met Ser 
1               5   


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-H2

<400>  130

Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-H3

<400>  131

Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr 
1               5                   10                  15      


<210>  132
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C VH

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Cys Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-L1

<400>  133

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-L2

<400>  134

Tyr Ser Ser Thr Leu Leu Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C HVR-L3

<400>  135

Gln Gln Ser Ile Thr Leu Pro Pro Thr 
1               5                   


<210>  136
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-digoxigenin antibody VH28C VL

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  137
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  137

Asp Thr Phe Phe Gln 
1               5   


<210>  138
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  138

Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  139

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  140
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-biotin antibody VH28C VH

<400>  140

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ser Ser Gly Phe Cys Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Lys Gln Arg Pro Glu Glu Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  141
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  141

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  142

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  143

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  144
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-H1

<400>  145

Asp Thr Phe Phe Gln 
1               5   


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-H2

<400>  146

Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-H3

<400>  147

Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  148
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C VH

<400>  148

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Phe Cys Asn Lys Asp Thr 
            20                  25                  30          


Phe Phe Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Phe Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Thr Tyr Gly Ala Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-L1

<400>  149

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-L2

<400>  150

Ser Ala Lys Thr Leu Ala Asp 
1               5           


<210>  151
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C HVR-L3

<400>  151

Gln His Phe Trp Ser Ser Ile Tyr Thr 
1               5                   


<210>  152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-biotin antibody VH28C VL

<400>  152

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Ile Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  153
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  153

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  154
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  154

Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  155
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  155

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  156
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine anti-theophylline antibody VH28C VH

<400>  156

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Cys Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Phe Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  157
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  157

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  158
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  158

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  159
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  159

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  160
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  160

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Leu Lys Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-H1

<400>  161

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-H2

<400>  162

Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-H3

<400>  163

Trp Val Asp Tyr Phe Asp Tyr 
1               5           


<210>  164
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C VH

<400>  164

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Cys Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Arg Tyr Ser Gly His Thr Gly Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  165
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-L1

<400>  165

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Arg Tyr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-L2

<400>  166

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C HVR-L3

<400>  167

Tyr Gln Gly Thr His Ala Pro Tyr Thr 
1               5                   


<210>  168
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized anti-theophylline antibody VH28C VL

<400>  168

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Arg Tyr Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Tyr Gln Gly 
                85                  90                  95      


Thr His Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  169
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  169

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  170
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  171
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  171

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  172
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  172

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  173
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  173

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  174
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  174

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  175
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  175

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Gly Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  176
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 01 - Ac IK Pqa 
       R(Pbf)H(Trt)Y(tBu)LN(Trt)W(Boc)VT(But)R(Pbf)Q(Trt)-MeArg(Mtr)-Y(t
       Bu)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  176

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  177
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 02


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-dig

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  177

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  178
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 03


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-4Abu-NH2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  178

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  179
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 04


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-4Abu-dig

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(24)
<223>  X=Me-ARG

<400>  179

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 05


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-4Abu-NH2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  180

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  181
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 06 - 
       PEG2-IK(ivDde)-Pqa-R(Pbf)H(Trt)Y(tBu)LN(Trt)W(Boc)VT(tBu)R(Pbf)Q(
       Trt)-MeArg(Mtr)-Y(tBu)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=PEG2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  -ivDde

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X=Me-ARG

<400>  181

Xaa Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15      


<210>  182
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 07


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=PEG2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  -PEG3-Cys-Abu-NH2

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X=Me-ARG

<400>  182

Xaa Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15      


<210>  183
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 08


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=PEG2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  -PEG3-Cys-4Abu-dig

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X=Me-ARG

<400>  183

Xaa Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15      


<210>  184
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 09


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG2-biotin

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  184

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  185
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 10


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys--Ala-biotin

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  185

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  186
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 11


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-PEG2-biotin

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  186

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  187
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 12


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-4-Abu-5-Fluo

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  187

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  188
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  haptenylated polypeptide 13


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  -PEG3-Cys-PEG2-5-Fluo

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=PQA

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=Me-ARG

<400>  188

Ile Lys Xaa Arg His Tyr Leu Asn Trp Val Thr Arg Gln Xaa Tyr 
1               5                   10                  15  


<210>  189
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-digoxigenin scdsFv VL

<400>  189

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  190
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-digoxigenin scdsFv VH

<400>  190

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ile Cys Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  191
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LeY antibody kappa light chain

<400>  191

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  192
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-LeY antibody heavy chain_ds44-100scFvDig-Cys53

<400>  192

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Asp Asp Ser Ser Ala Ala Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ala Trp Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser Trp Ile 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ser Ile Asn Ile 
            500                 505                 510         


Cys Ala Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gly Ser 
545                 550                 555                 560 


Pro Tyr Glu Tyr Asp Lys Ala Tyr Tyr Ser Met Ala Tyr Trp Gly Gln 
                565                 570                 575     


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
        595                 600                 605             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    610                 615                 620                 


Ser Gln Asp Ile Lys Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 


Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ser Ser Thr Leu Leu Ser Gly 
                645                 650                 655     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            660                 665                 670         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
        675                 680                 685             


Gln Ser Ile Thr Leu Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu 
    690                 695                 700                 


Ile Lys 
705     


