                         SEQUENCE LISTING

<110>  VERTEX PHARMACEUTICALS INCORPORATED
       Fleming, et al.
 
<120>  BIOMARKERS FOR HCV INFECTED PATIENTS

<130>  30852/47108A

<150>  61/673,625
<151>  2012-07-19

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Glu Gly Met Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys 
1               5                   10                  15      


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Phe Ser Leu Gln Trp Gly Glu Val Lys 
1               5                   10  


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Pro Leu Thr Asn Ala Ile Lys 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Glu Gln Asp Leu Pro Val Asn Ile Lys 
1               5                   10      


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Leu Glu Met Ala Gln Leu His 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Asp Gly Trp Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Asp Gly 
1               5                   10                  15      


Lys 
    


<210>  7
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Met Ala Val Ala Ala Asp Thr Leu Gln Arg 
1               5                   10      


<210>  8
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser 
1               5                   10                  15      


Gln Asn Glu Lys 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser 
1               5                   10                  15      


Gln Asn Glu Lys 
            20  


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Val Phe Gly Thr Glu Pro Asp Met Ile Arg 
1               5                   10      


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Phe Gln Tyr Ile Asp Leu His Gln Asp Glu Phe Val Gln Thr Leu 
1               5                   10                  15      


Lys 
    


<210>  12
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Phe Gln Tyr Ile Asp Leu His Gln Asp Glu Phe Val Gln Thr Leu 
1               5                   10                  15      


Lys 
    


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Trp Asn Tyr Ile Glu Gly Thr Lys 
1               5               


<210>  14
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Pro Ser Leu Ser Ile His Gly Ile Glu Gly Ala Phe Asp Glu Pro 
1               5                   10                  15      


Gly Thr Lys 
            


<210>  15
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Val Pro Pro Asn Asn Ser Asn Ala Ala Glu Asp Asp Leu Pro Thr 
1               5                   10                  15      


Val Glu Leu Gln Gly Val Val Pro Arg 
            20                  25  


<210>  16
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ser Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg 
1               5                   10                  


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Thr Phe Phe Gln Asn Gly Lys 
1               5               


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Ser His Glu Glu Val Glu Gly Leu Val Glu Lys 
1               5                   10          


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Leu Ser Glu Ala Leu Gly Gln Ile Phe Asp Ser Gln Arg 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Leu Ser Glu Ala Leu Gly Gln Ile Phe Asp Ser Gln Arg 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Leu Ser Glu Ala Leu Gly Gln Ile Phe Asp Ser Gln Arg 
1               5                   10                  


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Asp Ile Thr Leu Ser Ser Val Lys 
1               5                   


<210>  23
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Thr Leu Gln Ala Leu Glu Phe His Thr Val Pro Phe Gln Leu Leu 
1               5                   10                  15      


Ala Arg 
        


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Ala Ser Ala Tyr Gly Ala Arg 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Gln Leu Val Tyr Gln Ser Arg 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Thr His Thr Leu Asp Leu Ser Arg 
1               5                   


<210>  27
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Thr Ser Ser Phe Pro Cys Pro Ala Gly His Phe Asn Gly Phe Arg 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Thr Ser Ser Phe Pro Cys Pro Ala Gly His Phe Asn Gly Phe Arg 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Thr Ser Ser Phe Pro Cys Pro Ala Gly His Phe Asn Gly Phe Arg 
1               5                   10                  15      


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Thr Leu Gln Ala Leu Glu Phe His Thr Val Pro Phe 
1               5                   10          


<210>  31
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  31

Thr Leu Gln Ala Leu Glu Phe His Thr Val Pro Phe Gln Leu Leu Ala 
1               5                   10                  15      


Arg 
    


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys 
1               5                   10      


<210>  33
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Glu Ile Phe Tyr Arg 
1               5       


<210>  34
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  34

Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro Gln His Pro Ser Phe Leu 
1               5                   10                  15      


Phe Gln Asp Lys 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  35

Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro Gln His Pro Ser Phe Leu 
1               5                   10                  15      


Phe Gln Asp Lys 
            20  


<210>  36
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  36

Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro Gln His Pro Ser Phe Leu 
1               5                   10                  15      


Phe Gln Asp Lys Arg 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  37

Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro Gln His Pro Ser Phe Leu 
1               5                   10                  15      


Phe Gln Asp Lys Arg 
            20      


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Val Gly Tyr Leu Ile Thr Gly Tyr Gln Arg 
1               5                   10      


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Pro Asn Ala Ala Tyr Val Asn Met Ser Asn His His Arg 
1               5                   10                  15  


<210>  40
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Gly Gln Met Glu Ser Val Glu Ala Ala Met Ser Ser Lys 
1               5                   10                  


<210>  42
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Ile Gln His Ala Tyr Ser Glu Asn Ala Asp Phe Ser Gly Leu 
1               5                   10                  15      


Thr Glu Asp Asn Gly Leu Lys Leu Ser Asn Ala Ala His Lys 
            20                  25                  30  


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Ser Asp Ile Ala Ala Lys 
1               5           


<210>  44
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Pro Lys Leu Gly Arg Met Ala Ala Ser Leu Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Glu Arg Gly Met Phe Ser Ser Pro Ser Pro Pro Pro 
            20                  25                  30          


Ala Leu Leu Glu Lys Val Phe Gln Tyr Ile Asp Leu His Gln Asp Glu 
        35                  40                  45              


Phe Val Gln Thr Leu Lys Glu Trp Val Ala Ile Glu Ser Asp Ser Val 
    50                  55                  60                  


Gln Pro Val Pro Arg Phe Arg Gln Glu Leu Phe Arg Met Met Ala Val 
65                  70                  75                  80  


Ala Ala Asp Thr Leu Gln Arg Leu Gly Ala Arg Val Ala Ser Val Asp 
                85                  90                  95      


Met Gly Pro Gln Gln Leu Pro Asp Gly Gln Ser Leu Pro Ile Pro Pro 
            100                 105                 110         


Val Ile Leu Ala Glu Leu Gly Ser Asp Pro Thr Lys Gly Thr Val Cys 
        115                 120                 125             


Phe Tyr Gly His Leu Asp Val Gln Pro Ala Asp Arg Gly Asp Gly Trp 
    130                 135                 140                 


Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Asp Gly Lys Leu Tyr Gly 
145                 150                 155                 160 


Arg Gly Ala Thr Asp Asn Lys Gly Pro Val Leu Ala Trp Ile Asn Ala 
                165                 170                 175     


Val Ser Ala Phe Arg Ala Leu Glu Gln Asp Leu Pro Val Asn Ile Lys 
            180                 185                 190         


Phe Ile Ile Glu Gly Met Glu Glu Ala Gly Ser Val Ala Leu Glu Glu 
        195                 200                 205             


Leu Val Glu Lys Glu Lys Asp Arg Phe Phe Ser Gly Val Asp Tyr Ile 
    210                 215                 220                 


Val Ile Ser Asp Asn Leu Trp Ile Ser Gln Arg Lys Pro Ala Ile Thr 
225                 230                 235                 240 


Tyr Gly Thr Arg Gly Asn Ser Tyr Phe Met Val Glu Val Lys Cys Arg 
                245                 250                 255     


Asp Gln Asp Phe His Ser Gly Thr Phe Gly Gly Ile Leu His Glu Pro 
            260                 265                 270         


Met Ala Asp Leu Val Ala Leu Leu Gly Ser Leu Val Asp Ser Ser Gly 
        275                 280                 285             


His Ile Leu Val Pro Gly Ile Tyr Asp Glu Val Val Pro Leu Thr Glu 
    290                 295                 300                 


Glu Glu Ile Asn Thr Tyr Lys Ala Ile His Leu Asp Leu Glu Glu Tyr 
305                 310                 315                 320 


Arg Asn Ser Ser Arg Val Glu Lys Phe Leu Phe Asp Thr Lys Glu Glu 
                325                 330                 335     


Ile Leu Met His Leu Trp Arg Tyr Pro Ser Leu Ser Ile His Gly Ile 
            340                 345                 350         


Glu Gly Ala Phe Asp Glu Pro Gly Thr Lys Thr Val Ile Pro Gly Arg 
        355                 360                 365             


Val Ile Gly Lys Phe Ser Ile Arg Leu Val Pro His Met Asn Val Ser 
    370                 375                 380                 


Ala Val Glu Lys Gln Val Thr Arg His Leu Glu Asp Val Phe Ser Lys 
385                 390                 395                 400 


Arg Asn Ser Ser Asn Lys Met Val Val Ser Met Thr Leu Gly Leu His 
                405                 410                 415     


Pro Trp Ile Ala Asn Ile Asp Asp Thr Gln Tyr Leu Ala Ala Lys Arg 
            420                 425                 430         


Ala Ile Arg Thr Val Phe Gly Thr Glu Pro Asp Met Ile Arg Asp Gly 
        435                 440                 445             


Ser Thr Ile Pro Ile Ala Lys Met Phe Gln Glu Ile Val His Lys Ser 
    450                 455                 460                 


Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser Gln 
465                 470                 475                 480 


Asn Glu Lys Ile Asn Arg Trp Asn Tyr Ile Glu Gly Thr Lys Leu Phe 
                485                 490                 495     


Ala Ala Phe Phe Leu Glu Met Ala Gln Leu His 
            500                 505         


<210>  45
<211>  2541
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  46
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  47
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asp Gln Cys Ile Tyr Asn Thr Thr Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Ile Ser Arg Tyr Val Gly Gly 
            100                 105                 110         


Gln Glu His Phe Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr 
        115                 120                 125             


Met Leu Ala Phe Asp Val Asn Asp Glu Lys Asn Trp Gly Leu Ser Val 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Arg Ile Pro Lys Ser Asp Val Val Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  48
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser 
1               5                   10                  15      


Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met 
            20                  25                  30          


Val Leu Trp Leu Lys Gly Val Thr Phe Asn Val Thr Thr Val Asp Thr 
        35                  40                  45              


Lys Arg Arg Thr Glu Thr Val Gln Lys Leu Cys Pro Gly Gly Gln Leu 
    50                  55                  60                  


Pro Phe Leu Leu Tyr Gly Thr Glu Val His Thr Asp Thr Asn Lys Ile 
65                  70                  75                  80  


Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu 
                85                  90                  95      


Ala Ala Leu Asn Pro Glu Ser Asn Thr Ala Gly Leu Asp Ile Phe Ala 
            100                 105                 110         


Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn 
        115                 120                 125             


Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu 
    130                 135                 140                 


Thr Ser Pro Leu Pro Glu Glu Val Asp Glu Thr Ser Ala Glu Asp Glu 
145                 150                 155                 160 


Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Thr Leu Ala 
                165                 170                 175     


Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys 
            180                 185                 190         


Lys Tyr Arg Gly Phe Thr Ile Pro Glu Ala Phe Arg Gly Val His Arg 
        195                 200                 205             


Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Thr Cys Pro 
    210                 215                 220                 


Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu 
225                 230                 235                 240 


Lys 
    


<210>  49
<211>  1066
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Val Phe His Thr Arg Thr Ile Glu Ser Ile Leu Glu Pro Val 
1               5                   10                  15      


Ala Gln Gln Ile Ser His Leu Val Ile Met His Glu Glu Gly Glu Val 
            20                  25                  30          


Asp Gly Lys Ala Ile Pro Asp Leu Thr Ala Pro Val Ala Ala Val Gln 
        35                  40                  45              


Ala Ala Val Ser Asn Leu Val Arg Val Gly Lys Glu Thr Val Gln Thr 
    50                  55                  60                  


Thr Glu Asp Gln Ile Leu Lys Arg Asp Met Pro Pro Ala Phe Ile Lys 
65                  70                  75                  80  


Val Glu Asn Ala Cys Thr Lys Leu Val Gln Ala Ala Gln Met Leu Gln 
                85                  90                  95      


Ser Asp Pro Tyr Ser Val Pro Ala Arg Asp Tyr Leu Ile Asp Gly Ser 
            100                 105                 110         


Arg Gly Ile Leu Ser Gly Thr Ser Asp Leu Leu Leu Thr Phe Asp Glu 
        115                 120                 125             


Ala Glu Val Arg Lys Ile Ile Arg Val Cys Lys Gly Ile Leu Glu Tyr 
    130                 135                 140                 


Leu Thr Val Ala Glu Val Val Glu Thr Met Glu Asp Leu Val Thr Tyr 
145                 150                 155                 160 


Thr Lys Asn Leu Gly Pro Gly Met Thr Lys Met Ala Lys Met Ile Asp 
                165                 170                 175     


Glu Arg Gln Gln Glu Leu Thr His Gln Glu His Arg Val Met Leu Val 
            180                 185                 190         


Asn Ser Met Asn Thr Val Lys Glu Leu Leu Pro Val Leu Ile Ser Ala 
        195                 200                 205             


Met Lys Ile Phe Val Thr Thr Lys Asn Ser Lys Asn Gln Gly Ile Glu 
    210                 215                 220                 


Glu Ala Leu Lys Asn Arg Asn Phe Thr Val Glu Lys Met Ser Ala Glu 
225                 230                 235                 240 


Ile Asn Glu Ile Ile Arg Val Leu Gln Leu Thr Ser Trp Asp Glu Asp 
                245                 250                 255     


Ala Trp Ala Ser Lys Asp Thr Glu Ala Met Lys Arg Ala Leu Ala Ser 
            260                 265                 270         


Ile Asp Ser Lys Leu Asn Gln Ala Lys Gly Trp Leu Arg Asp Pro Ser 
        275                 280                 285             


Ala Ser Pro Gly Asp Ala Gly Glu Gln Ala Ile Arg Gln Ile Leu Asp 
    290                 295                 300                 


Glu Ala Gly Lys Val Gly Glu Leu Cys Ala Gly Lys Glu Arg Arg Glu 
305                 310                 315                 320 


Ile Leu Gly Thr Cys Lys Met Leu Gly Gln Met Thr Asp Gln Val Ala 
                325                 330                 335     


Asp Leu Arg Ala Arg Gly Gln Gly Ser Ser Pro Val Ala Met Gln Lys 
            340                 345                 350         


Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys Val Glu 
        355                 360                 365             


Asn Ala Ala Arg Lys Leu Glu Ala Met Thr Asn Ser Lys Gln Ser Ile 
    370                 375                 380                 


Ala Lys Lys Ile Asp Ala Ala Gln Asn Trp Leu Ala Asp Pro Asn Gly 
385                 390                 395                 400 


Gly Pro Glu Gly Glu Glu Gln Ile Arg Gly Ala Leu Ala Glu Ala Arg 
                405                 410                 415     


Lys Ile Ala Glu Leu Cys Asp Asp Pro Lys Glu Arg Asp Asp Ile Leu 
            420                 425                 430         


Arg Ser Leu Gly Glu Ile Ser Ala Leu Thr Ser Lys Leu Ala Asp Leu 
        435                 440                 445             


Arg Arg Gln Gly Lys Gly Asp Ser Pro Glu Ala Arg Ala Leu Ala Lys 
    450                 455                 460                 


Gln Val Ala Thr Ala Leu Gln Asn Leu Gln Thr Lys Thr Asn Arg Ala 
465                 470                 475                 480 


Val Ala Asn Ser Arg Pro Ala Lys Ala Ala Val His Leu Glu Gly Lys 
                485                 490                 495     


Ile Glu Gln Ala Gln Arg Trp Ile Asp Asn Pro Thr Val Asp Asp Arg 
            500                 505                 510         


Gly Val Gly Gln Ala Ala Ile Arg Gly Leu Val Ala Glu Gly His Arg 
        515                 520                 525             


Leu Ala Asn Val Met Met Gly Pro Tyr Arg Gln Asp Leu Leu Ala Lys 
    530                 535                 540                 


Cys Asp Arg Val Asp Gln Leu Thr Ala Gln Leu Ala Asp Leu Ala Ala 
545                 550                 555                 560 


Arg Gly Glu Gly Glu Ser Pro Gln Ala Arg Ala Leu Ala Ser Gln Leu 
                565                 570                 575     


Gln Asp Ser Leu Lys Asp Leu Lys Ala Arg Met Gln Glu Ala Met Thr 
            580                 585                 590         


Gln Glu Val Ser Asp Val Phe Ser Asp Thr Thr Thr Pro Ile Lys Leu 
        595                 600                 605             


Leu Ala Val Ala Ala Thr Ala Pro Pro Asp Ala Pro Asn Arg Glu Glu 
    610                 615                 620                 


Val Phe Asp Glu Arg Ala Ala Asn Phe Glu Asn His Ser Gly Lys Leu 
625                 630                 635                 640 


Gly Ala Thr Ala Glu Lys Ala Ala Ala Val Gly Thr Ala Asn Lys Ser 
                645                 650                 655     


Thr Val Glu Gly Ile Gln Ala Ser Val Lys Thr Ala Arg Glu Leu Thr 
            660                 665                 670         


Pro Gln Val Val Ser Ala Ala Arg Ile Leu Leu Arg Asn Pro Gly Asn 
        675                 680                 685             


Gln Ala Ala Tyr Glu His Phe Glu Thr Met Lys Asn Gln Trp Ile Asp 
    690                 695                 700                 


Asn Val Glu Lys Met Thr Gly Leu Val Asp Glu Ala Ile Asp Thr Lys 
705                 710                 715                 720 


Ser Leu Leu Asp Ala Ser Glu Glu Ala Ile Lys Lys Asp Leu Asp Lys 
                725                 730                 735     


Cys Lys Val Ala Met Ala Asn Ile Gln Pro Gln Met Leu Val Ala Gly 
            740                 745                 750         


Ala Thr Ser Ile Ala Arg Arg Ala Asn Arg Ile Leu Leu Val Ala Lys 
        755                 760                 765             


Arg Glu Val Glu Asn Ser Glu Asp Pro Lys Phe Arg Glu Ala Val Lys 
    770                 775                 780                 


Ala Ala Ser Asp Glu Leu Ser Lys Thr Ile Ser Pro Met Val Met Asp 
785                 790                 795                 800 


Ala Lys Ala Val Ala Gly Asn Ile Ser Asp Pro Gly Leu Gln Lys Ser 
                805                 810                 815     


Phe Leu Asp Ser Gly Tyr Arg Ile Leu Gly Ala Val Ala Lys Val Arg 
            820                 825                 830         


Glu Ala Phe Gln Pro Gln Glu Pro Asp Phe Pro Pro Pro Pro Pro Asp 
        835                 840                 845             


Leu Glu Gln Leu Arg Leu Thr Asp Glu Leu Ala Pro Pro Lys Pro Pro 
    850                 855                 860                 


Leu Pro Glu Gly Glu Val Pro Pro Pro Arg Pro Pro Pro Pro Glu Glu 
865                 870                 875                 880 


Lys Asp Glu Glu Phe Pro Glu Gln Lys Ala Gly Glu Val Ile Asn Gln 
                885                 890                 895     


Pro Met Met Met Ala Ala Arg Gln Leu His Asp Glu Ala Arg Lys Trp 
            900                 905                 910         


Ser Ser Lys Gly Asn Asp Ile Ile Ala Ala Ala Lys Arg Met Ala Leu 
        915                 920                 925             


Leu Met Ala Glu Met Ser Arg Leu Val Arg Gly Gly Ser Gly Thr Lys 
    930                 935                 940                 


Arg Ala Leu Ile Gln Cys Ala Lys Asp Ile Ala Lys Ala Ser Asp Glu 
945                 950                 955                 960 


Val Thr Arg Leu Ala Lys Glu Val Ala Lys Gln Cys Thr Asp Lys Arg 
                965                 970                 975     


Ile Arg Thr Asn Leu Leu Gln Val Cys Glu Arg Ile Pro Thr Ile Ser 
            980                 985                 990         


Thr Gln Leu Lys Ile Leu Ser Thr  Val Lys Ala Thr Met  Leu Gly Arg 
        995                 1000                 1005             


Thr Asn  Ile Ser Asp Glu Glu  Ser Glu Gln Ala Thr  Glu Met Leu 
    1010                 1015                 1020             


Val His  Asn Ala Gln Asn Leu  Met Gln Ser Val Lys  Glu Thr Val 
    1025                 1030                 1035             


Arg Glu  Ala Glu Ala Ala Ser  Ile Lys Ile Arg Thr  Asp Ala Gly 
    1040                 1045                 1050             


Phe Thr  Leu Arg Trp Val Arg  Lys Thr Pro Trp Tyr  Gln 
    1055                 1060                 1065     


<210>  50
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


<210>  51
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  52
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr 
1               5                   10                  15      


Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp 
            20                  25                  30          


Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val 
        35                  40                  45              


Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln 
65                  70                  75                  80  


Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala 
                85                  90                  95      


Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu 
            100                 105                 110         


Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys 
        115                 120                 125             


Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr 
    130                 135                 140 


<210>  53
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp 
1               5                   10                  15      


Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Glu Ser Val 
            20                  25                  30          


Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys 
        35                  40                  45              


Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile 
    50                  55                  60                  


Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu 
65                  70                  75                  80  


Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln 
                85                  90                  95      


His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala Leu Arg Leu 
            100                 105                 110         


Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala Ala Ile Cys 
        115                 120                 125             


Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala 
    130                 135                 140                 


Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu 
145                 150                 155                 160 


Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val Ala Pro Ala 
                165                 170                 175     


Leu Phe Arg Gly Met Pro Ala His Phe Ser Asp Ser Ala Gln Thr Glu 
            180                 185                 190         


Ala Cys Tyr His Met Leu Ser Arg Pro Gln Pro Pro Pro Asp Pro Leu 
        195                 200                 205             


Leu Leu Gln Arg Leu Pro Arg Pro Ser Ser Leu Ser Asp Lys Thr Gln 
    210                 215                 220                 


Leu His Ser Arg Trp Leu Asp Ser Ser Arg Cys Leu Met Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ala Gly Asp Ala Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe 
                245                 250                 255     


Phe Asp Leu Asp Pro Lys Thr Asp Pro Val Arg Leu Thr Gln Leu Tyr 
            260                 265                 270         


Glu Gln Ala Arg Trp Asp Leu Leu Leu Glu Glu Ile Asp Cys Thr Glu 
        275                 280                 285             


Glu Glu Met Met Val Phe Ala Ala Leu Gln Tyr His Ile Asn Lys Leu 
    290                 295                 300                 


Ser Gln Ser Gly Glu Val Gly Glu Pro Ala Gly Thr Asp Pro Gly Leu 
305                 310                 315                 320 


Asp Asp Leu Asp Val Ala Leu Ser Asn Leu Glu Val Lys Leu Glu Gly 
                325                 330                 335     


Ser Ala Pro Thr Asp Val Leu Asp Ser Leu Thr Thr Ile Pro Glu Leu 
            340                 345                 350         


Lys Asp His Leu Arg Ile Phe Arg Pro Arg Lys Leu Thr Leu Lys Gly 
        355                 360                 365             


Tyr Arg Gln His Trp Val Val Phe Lys Glu Thr Thr Leu Ser Tyr Tyr 
    370                 375                 380                 


Lys Ser Gln Asp Glu Ala Pro Gly Asp Pro Ile Gln Gln Leu Asn Leu 
385                 390                 395                 400 


Lys Gly Cys Glu Val Val Pro Asp Val Asn Val Ser Gly Gln Lys Phe 
                405                 410                 415     


Cys Ile Lys Leu Leu Val Pro Ser Pro Glu Gly Met Ser Glu Ile Tyr 
            420                 425                 430         


Leu Arg Cys Gln Asp Glu Gln Gln Tyr Ala Arg Trp Met Ala Gly Cys 
        435                 440                 445             


Arg Leu Ala Ser Lys Gly Arg Thr Met Ala Asp Ser Ser Tyr Thr Ser 
    450                 455                 460                 


Glu Val Gln Ala Ile Leu Ala Phe Leu Ser Leu Gln Arg Thr Gly Ser 
465                 470                 475                 480 


Gly Gly Pro Gly Asn His Pro His Gly Pro Asp Ala Ser Ala Glu Gly 
                485                 490                 495     


Leu Asn Pro Tyr Gly Leu Val Ala Pro Arg Phe Gln Arg Lys Phe Lys 
            500                 505                 510         


Ala Lys Gln Leu Thr Pro Arg Ile Leu Glu Ala His Gln Asn Val Ala 
        515                 520                 525             


Gln Leu Ser Leu Ala Glu Ala Gln Leu Arg Phe Ile Gln Ala Trp Gln 
    530                 535                 540                 


Ser Leu Pro Asp Phe Gly Ile Ser Tyr Val Met Val Arg Phe Lys Gly 
545                 550                 555                 560 


Ser Arg Lys Asp Glu Ile Leu Gly Ile Ala Asn Asn Arg Leu Ile Arg 
                565                 570                 575     


Ile Asp Leu Ala Val Gly Asp Val Val Lys Thr Trp Arg Phe Ser Asn 
            580                 585                 590         


Met Arg Gln Trp Asn Val Asn Trp Asp Ile Arg Gln Val Ala Ile Glu 
        595                 600                 605             


Phe Asp Glu His Ile Asn Val Ala Phe Ser Cys Val Ser Ala Ser Cys 
    610                 615                 620                 


Arg Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg 
625                 630                 635                 640 


Glu Arg Ala Arg Gly Glu Glu Leu Asp Glu Asp Leu Phe Leu Gln Leu 
                645                 650                 655     


Thr Gly Gly His Glu Ala Phe 
            660             


<210>  54
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  55
<211>  2647
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly Asp Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  56
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  57
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Gly Ile Ile Pro Leu Pro Phe Gly Lys Pro Gln Pro Gln Ser 
1               5                   10                  15      


Arg Arg Arg Pro Leu Arg Pro Pro Ser Ala Ser Ser Ala Ser Arg Pro 
            20                  25                  30          


Ala Arg Gly Ser Leu Arg Arg Ala Met Ala Thr Ser Pro Gln Lys Ser 
        35                  40                  45              


Pro Ser Val Pro Lys Ser Pro Thr Pro Lys Ser Pro Pro Ser Arg Lys 
    50                  55                  60                  


Lys Asp Asp Ser Phe Leu Gly Lys Leu Gly Gly Thr Leu Ala Arg Arg 
65                  70                  75                  80  


Lys Lys Ala Lys Glu Val Ser Glu Leu Gln Glu Glu Gly Met Asn Ala 
                85                  90                  95      


Ile Asn Leu Pro Leu Ser Pro Ile Pro Phe Glu Leu Asp Pro Glu Asp 
            100                 105                 110         


Thr Met Leu Glu Glu Asn Glu Val Arg Thr Met Val Asp Pro Asn Ser 
        115                 120                 125             


Arg Ser Asp Pro Lys Leu Gln Glu Leu Met Lys Val Leu Ile Asp Trp 
    130                 135                 140                 


Ile Asn Asp Val Leu Val Gly Glu Arg Ile Ile Val Lys Asp Leu Ala 
145                 150                 155                 160 


Glu Asp Leu Tyr Asp Gly Gln Val Leu Gln Lys Leu Phe Glu Lys Leu 
                165                 170                 175     


Glu Ser Glu Lys Leu Asn Val Ala Glu Val Thr Gln Ser Glu Ile Ala 
            180                 185                 190         


Gln Lys Gln Lys Leu Gln Thr Val Leu Glu Lys Ile Asn Glu Thr Leu 
        195                 200                 205             


Lys Leu Pro Pro Arg Ser Ile Lys Trp Asn Val Asp Ser Val His Ala 
    210                 215                 220                 


Lys Ser Leu Val Ala Ile Leu His Leu Leu Val Ala Leu Ser Gln Tyr 
225                 230                 235                 240 


Phe Arg Ala Pro Ile Arg Leu Pro Asp His Val Ser Ile Gln Val Val 
                245                 250                 255     


Val Val Gln Lys Arg Glu Gly Ile Leu Gln Ser Arg Gln Ile Gln Glu 
            260                 265                 270         


Glu Ile Thr Gly Asn Thr Glu Ala Leu Ser Gly Arg His Glu Arg Asp 
        275                 280                 285             


Ala Phe Asp Thr Leu Phe Asp His Ala Pro Asp Lys Leu Asn Val Val 
    290                 295                 300                 


Lys Lys Thr Leu Ile Thr Phe Val Asn Lys His Leu Asn Lys Leu Asn 
305                 310                 315                 320 


Leu Glu Val Thr Glu Leu Glu Thr Gln Phe Ala Asp Gly Val Tyr Leu 
                325                 330                 335     


Val Leu Leu Met Gly Leu Leu Glu Gly Tyr Phe Val Pro Leu His Ser 
            340                 345                 350         


Phe Phe Leu Thr Pro Asp Ser Phe Glu Gln Lys Val Leu Asn Val Ser 
        355                 360                 365             


Phe Ala Phe Glu Leu Met Gln Asp Gly Gly Leu Glu Lys Pro Lys Pro 
    370                 375                 380                 


Arg Pro Glu Asp Ile Val Asn Cys Asp Leu Lys Ser Thr Leu Arg Val 
385                 390                 395                 400 


Leu Tyr Asn Leu Phe Thr Lys Tyr Arg Asn Val Glu 
                405                 410         


<210>  58
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  58

Tyr Ser Ser Asp Tyr Phe Gln Ala Pro Ser Asp Tyr Arg 
1               5                   10              


<210>  59
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  59

Thr Phe Val Asn Ile Thr Pro Ala Glu Val Gly Val Leu Val Gly Lys 
1               5                   10                  15      


<210>  60
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Asp Gly Leu Phe Ser Gly Asp Pro Asn Trp Phe Pro Lys 
1               5                   10                  


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  61

Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe Lys 
1               5                   10          


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  62

Ala Ala Ile Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys 
1               5                   10              


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  63

Phe Glu Asp Glu Asn Phe Ile Leu Lys 
1               5                   


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  64

Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys 
1               5                   10                  


