                         SEQUENCE LISTING

<110>  ICI Immunochemical Intelligence GmbH
 
<120>  IN-VITRO-ASSAY ZUR DIAGNOSE VON STRUNGEN DER HMOSTASE

<130>  GP100175DE00

<150>  DE102012107168.3
<151>  2013-08-03

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Leu Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser 
        515 


<210>  2
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Leu Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ala Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser 
        515 


<210>  3
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Ala Trp Asp Cys Ser Val 
            20                  25                  30          


Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala Ile Pro Gly Ala Pro 
        35                  40                  45              


Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gly Ala Asp Gly Arg Ser 
    50                  55                  60                  


Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp Leu Cys Glu His Phe 
65                  70                  75                  80  


Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr Ser Cys Met Cys Glu 
                85                  90                  95      


Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg Cys Glu Asp Val Asp 
            100                 105                 110         


Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln Arg Cys Val Asn Thr 
        115                 120                 125             


Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn Tyr Asp Leu Val Asp 
    130                 135                 140                 


Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu 
145                 150                 155                 160 


Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala 
                165                 170                 175     


Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Leu Phe 
            180                 185                 190         


Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala 
        195                 200                 205             


Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys 
    210                 215                 220                 


Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys 
225                 230                 235                 240 


His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala 
                245                 250                 255     


Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly Lys Val Asp Gly 
            260                 265                 270         


Gly Asp Ser Gly Ser Gly Glu Pro Pro Pro Ser Pro Thr Pro Gly Ser 
        275                 280                 285             


Thr Leu Thr Pro Pro Ala Val Gly Leu Val His Ser 
    290                 295                 300 


<210>  4
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Ala Trp Asp Cys Ser Val 
            20                  25                  30          


Glu Asn Gly Gly Cys Glu His Ala Cys Asn Ala Ile Pro Gly Ala Pro 
        35                  40                  45              


Arg Cys Gln Cys Pro Ala Gly Ala Ala Leu Gln Ala Asp Gly Arg Ser 
    50                  55                  60                  


Cys Thr Ala Ser Ala Thr Gln Ser Cys Asn Asp Leu Cys Glu His Phe 
65                  70                  75                  80  


Cys Val Pro Asn Pro Asp Gln Pro Gly Ser Tyr Ser Cys Met Cys Glu 
                85                  90                  95      


Thr Gly Tyr Arg Leu Ala Ala Asp Gln His Arg Cys Glu Asp Val Asp 
            100                 105                 110         


Asp Cys Ile Leu Glu Pro Ser Pro Cys Pro Gln Arg Cys Val Asn Thr 
        115                 120                 125             


Gln Gly Gly Phe Glu Cys His Cys Tyr Pro Asn Tyr Asp Leu Val Asp 
    130                 135                 140                 


Gly Glu Cys Val Glu Pro Val Asp Pro Cys Phe Arg Ala Asn Cys Glu 
145                 150                 155                 160 


Tyr Gln Cys Gln Pro Leu Asn Gln Thr Ser Tyr Leu Cys Val Cys Ala 
                165                 170                 175     


Glu Gly Phe Ala Pro Ile Pro His Glu Pro His Arg Cys Gln Leu Phe 
            180                 185                 190         


Cys Asn Gln Thr Ala Cys Pro Ala Asp Cys Asp Pro Asn Thr Gln Ala 
        195                 200                 205             


Ser Cys Glu Cys Pro Glu Gly Tyr Ile Leu Asp Asp Gly Phe Ile Cys 
    210                 215                 220                 


Thr Asp Ile Asp Glu Cys Glu Asn Gly Gly Phe Cys Ser Gly Val Cys 
225                 230                 235                 240 


His Asn Leu Pro Gly Thr Phe Glu Cys Ile Cys Gly Pro Asp Ser Ala 
                245                 250                 255     


Leu Ala Arg His Ile Gly Thr Asp Cys Asp Ser Gly Lys Val Asp Gly 
            260                 265                 270         


Gly Asp Ser Gly Ala Gly Glu Pro Pro Pro Ser Pro Thr Pro Gly Ser 
        275                 280                 285             


Thr Leu Thr Pro Pro Ala Val Gly Leu Val His Ser 
    290                 295                 300 


