SEQUENCE LISTING

<110>   Novartis AG

<120>   Stabilised proteins for immunizing against Staphylococcus aureus

<130>   PAT055154-WO-PCT

<140>   PCT/EP2013/
<141>   2013-08-29

<150>   US61/695,798
<151>   2012-08-31

<160>   48

<170>   SeqWin2010, version 1.0

<210>   1
<211>   97
<212>   PRT
<213>   Staphylococcus aureus

<400>   1
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln 
    

<210>   2
<211>   104
<212>   PRT
<213>   Staphylococcus aureus

<400>   2
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Cys Gln 
            20                  25                  30          

Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                  40                  45              

Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                  55                  60                  

Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                  70                  75                  80  

Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                  90                  95      

Gln Gly Leu Asp Arg Val Asn Pro 
            100                 

<210>   3
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   3
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Cys Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr 
    130                 135                 140                 

Ile Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp 
145                 150                 155                 160 

Val Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met 
                165                 170                 175     

Ala Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys 
            180                 185                 190         

Tyr Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205         

<210>   4
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   4
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Cys Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   5
<211>   29
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   5
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala 
            20                  25                  

<210>   6
<211>   73
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   6
Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp 
1               5                   10                  15      

Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala 
            20                  25                  30          

Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala 
        35                  40                  45              

Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile 
    50                  55                  60                  

Lys Gln Gly Leu Asp Arg Val Asn Pro 
65                  70              

<210>   7
<211>   30
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   30
<223>   Any amino acid that does not contain a free thiol group.

<400>   7
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Xaa 
            20                  25                  30  

<210>   8
<211>   30
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   8
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Ala 
            20                  25                  30  

<210>   9
<211>   74
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   1
<223>   Any amino acid that does not contain a free thiol group.

<400>   9
Xaa Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp 
1               5                   10                  15      

Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met 
            20                  25                  30          

Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys 
        35                  40                  45              

Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser 
    50                  55                  60                  

Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
65                  70                  

<210>   10
<211>   74
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   10
Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp 
1               5                   10                  15      

Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met 
            20                  25                  30          

Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys 
        35                  40                  45              

Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser 
    50                  55                  60                  

Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
65                  70                  

<210>   11
<211>   103
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   30
<223>   Any amino acid that does not contain a free thiol group.

<400>   11
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Xaa Gln Lys 
            20                  25                  30          

Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu Gly 
        35                  40                  45              

Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys Phe 
    50                  55                  60                  

Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile Asp 
65                  70                  75                  80  

Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys Gln 
                85                  90                  95      

Gly Leu Asp Arg Val Asn Pro 
            100             

<210>   12
<211>   103
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   12
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Ala Gln Lys 
            20                  25                  30          

Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu Gly 
        35                  40                  45              

Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys Phe 
    50                  55                  60                  

Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile Asp 
65                  70                  75                  80  

Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys Gln 
                85                  90                  95      

Gly Leu Asp Arg Val Asn Pro 
            100             

<210>   13
<211>   102
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   13
Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln Ala 
1               5                   10                  15      

Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Gln Lys Gln 
            20                  25                  30          

Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu Gly Gln 
        35                  40                  45              

Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys Phe Gln 
    50                  55                  60                  

Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile Asp Asn 
65                  70                  75                  80  

Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys Gln Gly 
                85                  90                  95      

Leu Asp Arg Val Asn Pro 
            100         

<210>   14
<211>   131
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   14
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala 
    130     

<210>   15
<211>   132
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   132
<223>   Any amino acid that does not contain a free thiol group.

<400>   15
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala Xaa 
    130         

<210>   16
<211>   132
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   16
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala Ala 
    130         

<210>   17
<211>   132
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   17
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala 
    130         

<210>   18
<211>   133
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   133
<223>   Any amino acid that does not contain a free thiol group.

<400>   18
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Xaa 
    130             

<210>   19
<211>   133
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   19
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Ala 
    130             

<210>   20
<211>   205
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   132
<223>   Any amino acid that does not contain a free thiol group.

<400>   20
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala Xaa Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu 
    130                 135                 140                 

Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu 
145                 150                 155                 160 

Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp 
                165                 170                 175     

His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp 
            180                 185                 190         

Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205 

<210>   21
<211>   205
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   21
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu 
    130                 135                 140                 

Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu 
145                 150                 155                 160 

Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp 
                165                 170                 175     

His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp 
            180                 185                 190         

Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205 

<210>   22
<211>   30
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   22
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala 
            20                  25                  30  

<210>   23
<211>   103
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   23
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Gln Lys 
            20                  25                  30          

Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu Gly 
        35                  40                  45              

Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys Phe 
    50                  55                  60                  

Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile Asp 
65                  70                  75                  80  

Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys Gln 
                85                  90                  95      

Gly Leu Asp Arg Val Asn Pro 
            100             

<210>   24
<211>   104
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   31
<223>   Any amino acid that does not contain a free thiol group.

<400>   24
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Xaa Gln 
            20                  25                  30          

Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                  40                  45              

Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                  55                  60                  

Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                  70                  75                  80  

Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                  90                  95      

Gln Gly Leu Asp Arg Val Asn Pro 
            100                 

<210>   25
<211>   104
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   25
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Ala Gln 
            20                  25                  30          

Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                  40                  45              

Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                  55                  60                  

Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                  70                  75                  80  

Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                  90                  95      

Gln Gly Leu Asp Arg Val Asn Pro 
            100                 

<210>   26
<211>   31
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   31
<223>   Any amino acid that does not contain a free thiol group.

<400>   26
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Xaa 
            20                  25                  30      

<210>   27
<211>   31
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   27
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Ala 
            20                  25                  30      

<210>   28
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   133
<223>   Any amino acid that does not contain a free thiol group.

<400>   28
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Xaa Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   29
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   29
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   30
<211>   205
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   30
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu 
    130                 135                 140                 

Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu 
145                 150                 155                 160 

Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp 
                165                 170                 175     

His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp 
            180                 185                 190         

Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205 

<210>   31
<211>   204
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   31
Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser 
1               5                   10                  15      

Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr 
            20                  25                  30          

Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser 
        35                  40                  45              

Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe 
    50                  55                  60                  

Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp 
65                  70                  75                  80  

Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
                85                  90                  95      

Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly 
            100                 105                 110         

Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp 
        115                 120                 125             

Ile Glu Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly 
    130                 135                 140                 

Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu 
145                 150                 155                 160 

Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His 
                165                 170                 175     

Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr 
            180                 185                 190         

Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 

<210>   32
<211>   132
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   32
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala 
    130         

<210>   33
<211>   133
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   133
<223>   Any amino acid that does not contain a free thiol group.

<400>   33
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Xaa 
    130             

<210>   34
<211>   133
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   34
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Ala 
    130             

<210>   35
<211>   133
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   35
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala 
    130             

<210>   36
<211>   134
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   134
<223>   Any amino acid that does not contain a free thiol group.

<400>   36
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Xaa 
    130                 

<210>   37
<211>   134
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   37
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Ala 
    130                 

<210>   38
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   133
<223>   Any amino acid that does not contain a free thiol group.

<400>   38
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Xaa Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   39
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   39
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   40
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   134
<223>   Any amino acid that does not contain a free thiol group.

<400>   40
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Xaa Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr 
    130                 135                 140                 

Ile Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp 
145                 150                 155                 160 

Val Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met 
                165                 170                 175     

Ala Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys 
            180                 185                 190         

Tyr Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205         

<210>   41
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   41
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr 
    130                 135                 140                 

Ile Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp 
145                 150                 155                 160 

Val Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met 
                165                 170                 175     

Ala Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys 
            180                 185                 190         

Tyr Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205         

<210>   42
<211>   206
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   42
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Met Gly Gly Tyr Lys Gly Ile Lys Ala 
            100                 105                 110         

Asp Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala 
        115                 120                 125             

Lys Asp Ile Glu Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile 
    130                 135                 140                 

Glu Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val 
145                 150                 155                 160 

Leu Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala 
                165                 170                 175     

Asp His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr 
            180                 185                 190         

Asp Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205     

<210>   43
<211>   205
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   43
Met Ala Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln 
1               5                   10                  15      

Ser Tyr Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu 
            20                  25                  30          

Thr Arg Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe 
        35                  40                  45              

Ser Arg Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys 
    50                  55                  60                  

Phe Ala Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala 
65                  70                  75                  80  

Asp Ala Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu 
                85                  90                  95      

Gln Ala Ser Gly Gly Gly Ser Gly Gly Tyr Lys Gly Ile Lys Ala Asp 
            100                 105                 110         

Gly Gly Lys Val Asp Gln Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys 
        115                 120                 125             

Asp Ile Glu Ala Gln Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu 
    130                 135                 140                 

Gly Ser Asp Trp Glu Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu 
145                 150                 155                 160 

Leu Ile Met Ala Lys Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp 
                165                 170                 175     

His Gln Lys Ala Ile Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp 
            180                 185                 190         

Thr Leu Ser Ile Lys Gln Gly Leu Asp Arg Val Asn Pro 
        195                 200                 205 

<210>   44
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<220>
<221>   Xaa
<222>   31
<223>   Any amino acid that does not contain a free thiol group.

<400>   44
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Xaa Gln 
            20                  25                  30          

Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                  40                  45              

Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                  55                  60                  

Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                  70                  75                  80  

Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                  90                  95      

Gln Gly Leu Asp Arg Val Asn Pro Ala Ser Gly Gly Gly Ser Met Ala 
            100                 105                 110         

Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser Tyr 
        115                 120                 125             

Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr Arg 
    130                 135                 140                 

Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser Arg 
145                 150                 155                 160 

Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe Ala 
                165                 170                 175     

Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp Ala 
            180                 185                 190         

Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
        195                 200                 205         

<210>   45
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Staphylococcus aureus protein variant

<400>   45
Met Gly Gly Tyr Lys Gly Ile Lys Ala Asp Gly Gly Lys Val Asp Gln 
1               5                   10                  15      

Ala Lys Gln Leu Ala Ala Lys Thr Ala Lys Asp Ile Glu Ala Ala Gln 
            20                  25                  30          

Lys Gln Thr Gln Gln Leu Ala Glu Tyr Ile Glu Gly Ser Asp Trp Glu 
        35                  40                  45              

Gly Gln Phe Ala Asn Lys Val Lys Asp Val Leu Leu Ile Met Ala Lys 
    50                  55                  60                  

Phe Gln Glu Glu Leu Val Gln Pro Met Ala Asp His Gln Lys Ala Ile 
65                  70                  75                  80  

Asp Asn Leu Ser Gln Asn Leu Ala Lys Tyr Asp Thr Leu Ser Ile Lys 
                85                  90                  95      

Gln Gly Leu Asp Arg Val Asn Pro Ala Ser Gly Gly Gly Ser Met Ala 
            100                 105                 110         

Met Ile Lys Met Ser Pro Glu Glu Ile Arg Ala Lys Ser Gln Ser Tyr 
        115                 120                 125             

Gly Gln Gly Ser Asp Gln Ile Arg Gln Ile Leu Ser Asp Leu Thr Arg 
    130                 135                 140                 

Ala Gln Gly Glu Ile Ala Ala Asn Trp Glu Gly Gln Ala Phe Ser Arg 
145                 150                 155                 160 

Phe Glu Glu Gln Phe Gln Gln Leu Ser Pro Lys Val Glu Lys Phe Ala 
                165                 170                 175     

Gln Leu Leu Glu Glu Ile Lys Gln Gln Leu Asn Ser Thr Ala Asp Ala 
            180                 185                 190         

Val Gln Glu Gln Asp Gln Gln Leu Ser Asn Asn Phe Gly Leu Gln 
        195                 200                 205         

<210>   46
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   linker peptide

<400>   46
Ala Ser Gly Gly Gly Ser 
1               5       

<210>   47
<211>   6
<212>   PRT
<213>   linker peptide

<400>   47
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   48
<211>   4
<212>   PRT
<213>   linker peptide

<400>   48
Gly Gly Gly Gly 
1               

