                         SEQUENCE LISTING

<110>  Argen-X BV
 
<120>  METHOD FOR PRODUCING ANTIBODY MOLECULES HAVING INTER-SPECIES, 
       INTRA-TARGET CROSS-REACTIVITY

<130>  NLW/P124542WO00

<150>  US61/695,664
<151>  2012-08-31

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  VH Sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Val Ile Asn Thr Arg Ser Gly Ile Thr His Tyr Val Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Ile Gln Gly Leu Ile Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  2

Leu Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser 
            20                  25                  30          


Val Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Leu Lys 
        35                  40                  45              


Leu Leu Ile His Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Thr Leu Ala Ile Ser Gly 
65                  70                  75                  80  


Val Glu Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ala 
                85                  90                  95      


Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110 


<210>  3
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  3

Leu Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Ser Ile Ser Thr 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Leu Leu 
        35                  40                  45              


Val Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Thr Gly Ser Gly Thr Lys Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Ser Tyr Phe Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  4
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  4

Leu Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Arg Ser 
            20                  25                  30          


Phe Ile Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Arg Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Thr Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  5
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  5

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Met Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Asn Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  6
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  6

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  7

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  8

Leu Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Ser Ile Arg Ser 
            20                  25                  30          


Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Arg Ile Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ala Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ser Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Thr Trp Pro 
                85                  90                  95      


Leu Ser Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  9
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  9

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Ser Ile Arg Ser 
            20                  25                  30          


Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Arg Ile Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ala Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Glu Tyr Ala Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  10
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VK Sequence

<400>  10

Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Ser Val Thr Ile Ser Cys Gln Ala Ser Glu Asn Ile Gly Thr 
            20                  25                  30          


Gln Leu Phe Trp Tyr Gln Gln Asn Ala Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Thr Ile Ser Gly Val Glu 
65                  70                  75                  80  


Thr Gly Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105             


<210>  11
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  VL Sequence

<400>  11

Leu Ser Tyr Glu Leu Thr Gln Pro Ser Ala Val Ser Val Leu Leu Gly 
1               5                   10                  15      


Gln Thr Ala Lys Ile Thr Cys Gln Gly Gly Ser Leu Arg Ser Ser Tyr 
            20                  25                  30          


Ala His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Thr Glu Asp Asp Ser Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Gly Thr Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala 
65                  70                  75                  80  


Asp Asp Glu Ala Asp Tyr His Cys Gln Ser Ala Asp Ile Ser Gly Asn 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210>  12
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  VL Sequence

<400>  12

His Ser Ala Val Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Asn Phe Gly Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asp Arg Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Gly Arg Ser Thr Leu Thr Ile Ser Gly Ala Gln Ser Gly 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ala Asp Leu Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105         


<210>  13
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  VH Sequence

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Glu Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Ala Asp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Leu Trp Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Ile Val 
            100                 105                 110         


Ser Ser 
        


<210>  14
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  VH Sequence

<400>  14

Gln Leu Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Asn Ser Gly Gly Ser Tyr Thr Arg Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Ile Val Asn Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


