                         SEQUENCE LISTING

<110>  Fundaci Hospital Universitari Vall d'Hebron-Institut de 
       Recerca
 
<120>  New biomarkers for the diagnosis and/or prognosis of clear cell 
       Renal Cell Carcinoma

<130>  P2433PC00

<150>  EP12382350
<151>  2012-09-13

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PHOSPHORYLATION
<222>  (8)..(8)
<223>  Phosphorylated Serine

<400>  1

Asp Ala Thr Asn Ile Leu Val Xaa Pro Leu 
1               5                   10  


<210>  2
<211>  770
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (727)..(727)
<223>  PHOSPHORYLATION

<400>  2

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  3
<211>  770
<212>  PRT
<213>  Mus musculus


<220>
<221>  MOD_RES
<222>  (727)..(727)
<223>  PHOSPHORYLATION

<400>  3

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Asp Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


