                               SEQUENCE LISTING

<110> ALEXION PHARMACEUTICALS, INC.
 
<120> SCREENING ASSAYS FOR COMPLEMENT COMPONENT C5 ANTAGONISTS

<130> ALXN-165-WO1

<140>
<141> 2013-09-20	 

<150> 61/704,392
<151> 2012-09-21

<150> 61/775,156
<151> 2013-03-08

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 5444
<212> DNA
<213> Homo sapiens

<400> 1
ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc       60

tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct      120

gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt      180

aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag      240

aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa      300

aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga      360

atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact      420

ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa      480

agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa      540

attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat      600

ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat      660

tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat      720

ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat      780

aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa      840

gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt      900

gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa      960

gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt     1020

tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg     1080

gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa     1140

gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat     1200

gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga     1260

gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa     1320

actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca     1380

tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg     1440

ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata     1500

actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag     1560

aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct     1620

tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct     1680

gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct     1740

cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg     1800

gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc     1860

aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca     1920

ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat     1980

gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga     2040

agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag     2100

aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca     2160

cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc     2220

cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc     2280

ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa     2340

gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc     2400

tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag     2460

gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga     2520

gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt     2580

gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag     2640

ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg     2700

acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact     2760

tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg     2820

gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga     2880

aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt     2940

ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc     3000

atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc     3060

ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct     3120

gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt     3180

atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact     3240

tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac     3300

caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga     3360

tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa     3420

gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc     3480

gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt     3540

gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc     3600

ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct     3660

ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac     3720

agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc     3780

accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa     3840

gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc     3900

ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct     3960

tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg     4020

ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg     4080

gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc     4140

ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac     4200

tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca     4260

tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa     4320

gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa     4380

gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga     4440

ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac     4500

gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt     4560

cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag     4620

gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag     4680

attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag     4740

tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct     4800

gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag     4860

tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc     4920

taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg     4980

tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc     5040

taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt     5100

cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac     5160

tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt     5220

ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac     5280

cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc     5340

gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat     5400

accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc                      5444


<210> 2
<211> 1676
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210> 3
<211> 1658
<212> PRT
<213> Homo sapiens

<400> 3
Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg Val Gly 
1               5                   10                  15      


Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu Ala Phe 
            20                  25                  30          


Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe Ser Tyr 
        35                  40                  45              


Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln Asn Ser 
    50                  55                  60                  


Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln Asn Pro 
65                  70                  75                  80  


Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser Lys Ser 
                85                  90                  95      


Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile His Thr 
            100                 105                 110         


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg Val Tyr 
        115                 120                 125             


Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val Leu Thr 
    130                 135                 140                 


Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu Ile Asp 
145                 150                 155                 160 


His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser Asn Pro 
                165                 170                 175     


Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp Phe Ser 
            180                 185                 190         


Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu Pro His 
        195                 200                 205             


Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr Lys Asn 
    210                 215                 220                 


Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr Asn Lys 
225                 230                 235                 240 


Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg Glu Asp 
                245                 250                 255     


Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln Asn Thr 
            260                 265                 270         


Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu Thr Ala 
        275                 280                 285             


Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe Ser Glu 
305                 310                 315                 320 


Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr Lys Leu 
                325                 330                 335     


Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro Tyr Pro 
            340                 345                 350         


Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly Gly Val 
        355                 360                 365             


Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu Thr Ser 
    370                 375                 380                 


Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly Val Ala 
385                 390                 395                 400 


Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu Phe Asn 
                405                 410                 415     


Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu 
            420                 425                 430         


Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr Leu Tyr 
        435                 440                 445             


Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu His Leu 
    450                 455                 460                 


Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile Thr His 
465                 470                 475                 480 


Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe Gly Thr 
                485                 490                 495     


Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile Pro Val 
            500                 505                 510         


Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr Ile Val 
        515                 520                 525             


Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp Leu Asn 
    530                 535                 540                 


Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser Pro Asp 
545                 550                 555                 560 


Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met Ala Thr 
                565                 570                 575     


Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala Val Tyr 
            580                 585                 590         


Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe Gln Phe 
        595                 600                 605             


Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
    610                 615                 620                 


Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn Ala Asn 
625                 630                 635                 640 


Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile Leu Arg 
                645                 650                 655     


Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr 
            660                 665                 670         


Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn 
        675                 680                 685             


Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro 
    690                 695                 700                 


Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu 
705                 710                 715                 720 


Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met 
                725                 730                 735     


Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro 
            740                 745                 750         


Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys Gln Leu 
        755                 760                 765             


Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln Gly Ile 
    770                 775                 780                 


Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys Ala Lys 
785                 790                 795                 800 


Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser Val Val 
                805                 810                 815     


Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr Arg Thr 
            820                 825                 830         


Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly Ile Cys 
        835                 840                 845             


Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys 
    850                 855                 860                 


Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe 
865                 870                 875                 880 


Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu 
                885                 890                 895     


Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val 
            900                 905                 910         


Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro 
        915                 920                 925             


Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg 
    930                 935                 940                 


Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser 
945                 950                 955                 960 


Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln 
                965                 970                 975     


Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala 
            980                 985                 990         


Glu Leu Met Ser Val Val Pro Val  Phe Tyr Val Phe His  Tyr Leu Glu 
        995                 1000                 1005             


Thr Gly  Asn His Trp Asn Ile  Phe His Ser Asp Pro  Leu Ile Glu 
    1010                 1015                 1020             


Lys Gln  Lys Leu Lys Lys Lys  Leu Lys Glu Gly Met  Leu Ser Ile 
    1025                 1030                 1035             


Met Ser  Tyr Arg Asn Ala Asp  Tyr Ser Tyr Ser Val  Trp Lys Gly 
    1040                 1045                 1050             


Gly Ser  Ala Ser Thr Trp Leu  Thr Ala Phe Ala Leu  Arg Val Leu 
    1055                 1060                 1065             


Gly Gln  Val Asn Lys Tyr Val  Glu Gln Asn Gln Asn  Ser Ile Cys 
    1070                 1075                 1080             


Asn Ser  Leu Leu Trp Leu Val  Glu Asn Tyr Gln Leu  Asp Asn Gly 
    1085                 1090                 1095             


Ser Phe  Lys Glu Asn Ser Gln  Tyr Gln Pro Ile Lys  Leu Gln Gly 
    1100                 1105                 1110             


Thr Leu  Pro Val Glu Ala Arg  Glu Asn Ser Leu Tyr  Leu Thr Ala 
    1115                 1120                 1125             


Phe Thr  Val Ile Gly Ile Arg  Lys Ala Phe Asp Ile  Cys Pro Leu 
    1130                 1135                 1140             


Val Lys  Ile Asp Thr Ala Leu  Ile Lys Ala Asp Asn  Phe Leu Leu 
    1145                 1150                 1155             


Glu Asn  Thr Leu Pro Ala Gln  Ser Thr Phe Thr Leu  Ala Ile Ser 
    1160                 1165                 1170             


Ala Tyr  Ala Leu Ser Leu Gly  Asp Lys Thr His Pro  Gln Phe Arg 
    1175                 1180                 1185             


Ser Ile  Val Ser Ala Leu Lys  Arg Glu Ala Leu Val  Lys Gly Asn 
    1190                 1195                 1200             


Pro Pro  Ile Tyr Arg Phe Trp  Lys Asp Asn Leu Gln  His Lys Asp 
    1205                 1210                 1215             


Ser Ser  Val Pro Asn Thr Gly  Thr Ala Arg Met Val  Glu Thr Thr 
    1220                 1225                 1230             


Ala Tyr  Ala Leu Leu Thr Ser  Leu Asn Leu Lys Asp  Ile Asn Tyr 
    1235                 1240                 1245             


Val Asn  Pro Val Ile Lys Trp  Leu Ser Glu Glu Gln  Arg Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Phe Tyr Ser Thr Gln  Asp Thr Ile Asn Ala  Ile Glu Gly 
    1265                 1270                 1275             


Leu Thr  Glu Tyr Ser Leu Leu  Val Lys Gln Leu Arg  Leu Ser Met 
    1280                 1285                 1290             


Asp Ile  Asp Val Ser Tyr Lys  His Lys Gly Ala Leu  His Asn Tyr 
    1295                 1300                 1305             


Lys Met  Thr Asp Lys Asn Phe  Leu Gly Arg Pro Val  Glu Val Leu 
    1310                 1315                 1320             


Leu Asn  Asp Asp Leu Ile Val  Ser Thr Gly Phe Gly  Ser Gly Leu 
    1325                 1330                 1335             


Ala Thr  Val His Val Thr Thr  Val Val His Lys Thr  Ser Thr Ser 
    1340                 1345                 1350             


Glu Glu  Val Cys Ser Phe Tyr  Leu Lys Ile Asp Thr  Gln Asp Ile 
    1355                 1360                 1365             


Glu Ala  Ser His Tyr Arg Gly  Tyr Gly Asn Ser Asp  Tyr Lys Arg 
    1370                 1375                 1380             


Ile Val  Ala Cys Ala Ser Tyr  Lys Pro Ser Arg Glu  Glu Ser Ser 
    1385                 1390                 1395             


Ser Gly  Ser Ser His Ala Val  Met Asp Ile Ser Leu  Pro Thr Gly 
    1400                 1405                 1410             


Ile Ser  Ala Asn Glu Glu Asp  Leu Lys Ala Leu Val  Glu Gly Val 
    1415                 1420                 1425             


Asp Gln  Leu Phe Thr Asp Tyr  Gln Ile Lys Asp Gly  His Val Ile 
    1430                 1435                 1440             


Leu Gln  Leu Asn Ser Ile Pro  Ser Ser Asp Phe Leu  Cys Val Arg 
    1445                 1450                 1455             


Phe Arg  Ile Phe Glu Leu Phe  Glu Val Gly Phe Leu  Ser Pro Ala 
    1460                 1465                 1470             


Thr Phe  Thr Val Tyr Glu Tyr  His Arg Pro Asp Lys  Gln Cys Thr 
    1475                 1480                 1485             


Met Phe  Tyr Ser Thr Ser Asn  Ile Lys Ile Gln Lys  Val Cys Glu 
    1490                 1495                 1500             


Gly Ala  Ala Cys Lys Cys Val  Glu Ala Asp Cys Gly  Gln Met Gln 
    1505                 1510                 1515             


Glu Glu  Leu Asp Leu Thr Ile  Ser Ala Glu Thr Arg  Lys Gln Thr 
    1520                 1525                 1530             


Ala Cys  Lys Pro Glu Ile Ala  Tyr Ala Tyr Lys Val  Ser Ile Thr 
    1535                 1540                 1545             


Ser Ile  Thr Val Glu Asn Val  Phe Val Lys Tyr Lys  Ala Thr Leu 
    1550                 1555                 1560             


Leu Asp  Ile Tyr Lys Thr Gly  Glu Ala Val Ala Glu  Lys Asp Ser 
    1565                 1570                 1575             


Glu Ile  Thr Phe Ile Lys Lys  Val Thr Cys Thr Asn  Ala Glu Leu 
    1580                 1585                 1590             


Val Lys  Gly Arg Gln Tyr Leu  Ile Met Gly Lys Glu  Ala Leu Gln 
    1595                 1600                 1605             


Ile Lys  Tyr Asn Phe Ser Phe  Arg Tyr Ile Tyr Pro  Leu Asp Ser 
    1610                 1615                 1620             


Leu Thr  Trp Ile Glu Tyr Trp  Pro Arg Asp Thr Thr  Cys Ser Ser 
    1625                 1630                 1635             


Cys Gln  Ala Phe Leu Ala Asn  Leu Asp Glu Phe Ala  Glu Asp Ile 
    1640                 1645                 1650             


Phe Leu  Asn Gly Cys 
    1655             


<210> 4
<211> 21
<212> PRT
<213> Homo sapiens

<400> 4
Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys Cys Val Arg Gln Lys 
1               5                   10                  15      


Val Glu Gly Ser Ser 
            20      


<210> 5
<211> 95
<212> DNA
<213> Homo sapiens

<400> 5
tatatccgtg gtttcctgct acctccaacc atgggccttt tgggaatact ttgtttttta       60

atcttcctgg ggaaaacctg gggacaggag caaac                                  95


<210> 6
<211> 193
<212> DNA
<213> Homo sapiens

<400> 6
atatgtcatt tcagcaccaa aaatattccg tgttggagca tctgaaaata ttgtgattca       60

agtttatgga tacactgaag catttgatgc aacaatctct attaaaagtt atcctgataa      120

aaaatttagt tactcctcag gccatgttca tttatcctca gagaataaat tccaaaactc      180

tgcaatctta aca                                                         193


<210> 7
<211> 163
<212> DNA
<213> Homo sapiens

<400> 7
atacaaccaa aacaattgcc tggaggacaa aacccagttt cttatgtgta tttggaagtt       60

gtatcaaagc atttttcaaa atcaaaaaga atgccaataa cctatgacaa tggatttctc      120

ttcattcata cagacaaacc tgtttatact ccagaccagt cag                        163


<210> 8
<211> 71
<212> DNA
<213> Homo sapiens

<400> 8
taaaagttag agtttattcg ttgaatgacg acttgaagcc agccaaaaga gaaactgtct       60

taactttcat a                                                            71


<210> 9
<211> 92
<212> DNA
<213> Homo sapiens

<400> 9
gatcctgaag gatcagaagt tgacatggta gaagaaattg atcatattgg aattatctct       60

tttcctgact tcaagattcc gtctaatcct ag                                     92


<210> 10
<211> 83
<212> DNA
<213> Homo sapiens

<400> 10
atatggtatg tggacgatca aggctaaata taaagaggac ttttcaacaa ctggaaccgc       60

atattttgaa gttaaagaat atg                                               83


<210> 11
<211> 91
<212> DNA
<213> Homo sapiens

<400> 11
aagtcaaaac ctcatttcaa ttatttgcta acccaaacac aaaattaagt ttatggggaa       60

gctttacgag aactgtcaag tttgtttaac c                                      91


<210> 12
<211> 115
<212> DNA
<213> Homo sapiens

<400> 12
atatttttat aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga       60

agacttaaaa gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatg           115


<210> 13
<211> 127
<212> DNA
<213> Homo sapiens

<400> 13
ttgataaatg gaattgctca agtcacattt gattctgaaa cagcagtcaa agaactgtca       60

tactacagtt tagaagattt aaacaacaag tacctttata ttgctgtaac agtcatagag      120

tctacag                                                                127


<210> 14
<211> 116
<212> DNA
<213> Homo sapiens

<400> 14
gtggattttc tgaagaggca gaaatacctg gcatcaaata tgtcctctct ccctacaaac       60

tgaatttggt tgctactcct cttttcctga agcctgggat tccatatccc atcaag          116


<210> 15
<211> 186
<212> DNA
<213> Homo sapiens

<400> 15
gtgcaggtta aagattcgct tgaccagttg gtaggaggag tcccagtaac actgaatgca       60

caaacaattg atgtaaacca agagacatct gacttggatc caagcaaaag tgtaacacgt      120

gttgatgatg gagtagcttc ctttgtgctt aatctcccat ctggagtgac ggtgctggag      180

tttaat                                                                 186


<210> 16
<211> 204
<212> DNA
<213> Homo sapiens

<400> 16
gtcaaaactg atgctccaga tcttccagaa gaaaatcagg ccagggaagg ttaccgagca       60

atagcatact catctctcag ccaaagttac ctttatattg attggactga taaccataag      120

gctttgctag tgggagaaca tctgaatatt attgttaccc ccaaaagccc atatattgac      180

aaaataactc actataatta cttg                                             204


<210> 17
<211> 210
<212> DNA
<213> Homo sapiens

<400> 17
attttatcca agggcaaaat tatccacttt ggcacgaggg agaaattttc agatgcatct       60

tatcaaagta taaacattcc agtaacacag aacatggttc cttcatcccg acttctggtc      120

tattacatcg tcacaggaga acagacagca gaattagtgt ctgattcagt ctggttaaat      180

attgaagaaa aatgtggcaa ccagctccag                                       210


<210> 18
<211> 150
<212> DNA
<213> Homo sapiens

<400> 18
catgcttgta ggttcttaca tatatatact atatatagaa aataatatat aacaaagtat       60

catataatgc atatacagta atatataata tatatactaa aatatgtaaa tatagcaata      120

ttatatagaa cataagctta aaatatgttt                                       150


<210> 19
<211> 130
<212> DNA
<213> Homo sapiens

<400> 19
gtatttcaat tcttagagaa gagtgatctg ggctgtgggg caggtggtgg cctcaacaat       60

gccaatgtgt tccacctagc tggacttacc ttcctcacta atgcaaatgc agatgactcc      120

caagaaaatg                                                             130


<210> 20
<211> 63
<212> DNA
<213> Homo sapiens

<400> 20
atgaaccttg taaagaaatt ctcaggccaa gaagaacgct gcaaaagaag atagaagaaa       60

tag                                                                     63


<210> 21
<211> 198
<212> DNA
<213> Homo sapiens

<400> 21
ctgctaaata taaacattca gtagtgaaga aatgttgtta cgatggagcc tgcgttaata       60

atgatgaaac ctgtgagcag cgagctgcac ggattagttt agggccaaga tgcatcaaag      120

ctttcactga atgttgtgtc gtcgcaagcc agctccgtgc taatatctct cataaagaca      180

tgcaattggg aaggctac                                                    198


<210> 22
<211> 91
<212> DNA
<213> Homo sapiens

<400> 22
acatgaagac cctgttacca gtaagcaagc cagaaattcg gagttatttt ccagaaagct       60

ggttgtggga agttcatctt gttcccagaa g                                      91


<210> 23
<211> 74
<212> DNA
<213> Homo sapiens

<400> 23
aaaacagttg cagtttgccc tacctgattc tctaaccacc tgggaaattc aaggcgttgg       60

catttcaaac actg                                                         74


<210> 24
<211> 140
<212> DNA
<213> Homo sapiens

<400> 24
gtatatgtgt tgctgatact gtcaaggcaa aggtgttcaa agatgtcttc ctggaaatga       60

atataccata ttctgttgta cgaggagaac agatccaatt gaaaggaact gtttacaact      120

ataggacttc tgggatgcag                                                  140


<210> 25
<211> 228
<212> DNA
<213> Homo sapiens

<400> 25
ttctgtgtta aaatgtctgc tgtggaggga atctgcactt cggaaagccc agtcattgat       60

catcagggca caaagtcctc caaatgtgtg cgccagaaag tagagggctc ctccagtcac      120

ttggtgacat tcactgtgct tcctctggaa attggccttc acaacatcaa tttttcactg      180

gagacttggt ttggaaaaga aatcttagta aaaacattac gagtggtg                   228


<210> 26
<211> 61
<212> DNA
<213> Homo sapiens

<400> 26
ccagaaggtg tcaaaaggga aagctattct ggtgttactt tggatcctag gggtatttat       60

g                                                                       61


<210> 27
<211> 90
<212> DNA
<213> Homo sapiens

<400> 27
gtaccattag cagacgaaag gagttcccat acaggatacc cttagatttg gtccccaaaa       60

cagaaatcaa aaggattttg agtgtaaaag                                        90


<210> 28
<211> 213
<212> DNA
<213> Homo sapiens

<400> 28
gactgcttgt aggtgagatc ttgtctgcag ttctaagtca ggaaggcatc aatatcctaa       60

cccacctccc caaagggagt gcagaggcgg agctgatgag cgttgtccca gtattctatg      120

tttttcacta cctggaaaca ggaaatcatt ggaacatttt tcattctgac ccattaattg      180

aaaagcagaa actgaagaaa aaattaaaag aag                                   213


<210> 29
<211> 76
<212> DNA
<213> Homo sapiens

<400> 29
ggatgttgag cattatgtcc tacagaaatg ctgactactc ttacagtgtg tggaagggtg       60

gaagtgctag cacttg                                                       76


<210> 30
<211> 160
<212> DNA
<213> Homo sapiens

<400> 30
gttaacagct tttgctttaa gagtacttgg acaagtaaat aaatacgtag agcagaacca       60

aaattcaatt tgtaattctt tattgtggct agttgagaat tatcaattag ataatggatc      120

tttcaaggaa aattcacagt atcaaccaat aaaattacag                            160


<210> 31
<211> 96
<212> DNA
<213> Homo sapiens

<400> 31
ggtaccttgc ctgttgaagc ccgagagaac agcttatatc ttacagcctt tactgtgatt       60

ggaattagaa aggctttcga tatatgcccc ctggtg                                 96


<210> 32
<211> 172
<212> DNA
<213> Homo sapiens

<400> 32
aaaatcgaca cagctctaat taaagctgac aactttctgc ttgaaaatac actgccagcc       60

cagagcacct ttacattggc catttctgcg tatgctcttt ccctgggaga taaaactcac      120

ccacagtttc gttcaattgt ttcagctttg aagagagaag ctttggttaa ag              172


<210> 33
<211> 206
<212> DNA
<213> Homo sapiens

<400> 33
gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac agctctgtac       60

ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc accagtctga      120

acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa gagcagaggt      180

atggaggtgg cttttattca acccag                                           206


<210> 34
<211> 153
<212> DNA
<213> Homo sapiens

<400> 34
gacacaatca atgccattga gggcctgacg gaatattcac tcctggttaa acaactccgc       60

ttgagtatgg acatcgatgt ttcttacaag cataaaggtg ccttacataa ttataaaatg      120

acagacaaga atttccttgg gaggccagta gag                                   153


<210> 35
<211> 63
<212> DNA
<213> Homo sapiens

<400> 35
gtgcttctca atgatgacct cattgtcagt acaggatttg gcagtggctt ggctacagta       60

cat                                                                     63


<210> 36
<211> 82
<212> DNA
<213> Homo sapiens

<400> 36
gtaacaactg tagttcacaa aaccagtacc tctgaggaag tttgcagctt ttatttgaaa       60

atcgatactc aggatattga ag                                                82


<210> 37
<211> 58
<212> DNA
<213> Homo sapiens

<400> 37
catcccacta cagaggctac ggaaactctg attacaaacg catagtagca tgtgccag         58


<210> 38
<211> 103
<212> DNA
<213> Homo sapiens

<400> 38
ctacaagccc agcagggaag aatcatcatc tggatcctct catgcggtga tggacatctc       60

cttgcctact ggaatcagtg caaatgaaga agacttaaaa gcc                        103


<210> 39
<211> 75
<212> DNA
<213> Homo sapiens

<400> 39
cttgtggaag gggtggatca actattcact gattaccaaa tcaaagatgg acatgttatt       60

ctgcaactga attcg                                                        75


<210> 40
<211> 106
<212> DNA
<213> Homo sapiens

<400> 40
attccctcca gtgatttcct ttgtgtacga ttccggatat ttgaactctt tgaagttggg       60

tttctcagtc ctgccacttt cacagtgtac gaataccaca gaccag                     106


<210> 41
<211> 84
<212> DNA
<213> Homo sapiens

<400> 41
ataaacagtg taccatgttt tatagcactt ccaatatcaa aattcagaaa gtctgtgaag       60

gagccgcgtg caagtgtgta gaag                                              84


<210> 42
<211> 90
<212> DNA
<213> Homo sapiens

<400> 42
ctgattgtgg gcaaatgcag gaagaattgg atctgacaat ctctgcagag acaagaaaac       60

aaacagcatg taaaccagag attgcatatg                                        90


<210> 43
<211> 84
<212> DNA
<213> Homo sapiens

<400> 43
cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag tacaaggcaa       60

cccttctgga tatctacaaa actg                                              84


<210> 44
<211> 139
<212> DNA
<213> Homo sapiens

<400> 44
gggaagctgt tgctgagaaa gactctgaga ttaccttcat taaaaaggta acctgtacta       60

acgctgagct ggtaaaagga agacagtact taattatggg taaagaagcc ctccagataa      120

aatacaattt cagtttcag                                                   139


<210> 45
<211> 534
<212> DNA
<213> Homo sapiens

<400> 45
gtacatctac cctttagatt ccttgacctg gattgaatac tggcctagag acacaacatg       60

ttcatcgtgt caagcatttt tagctaattt agatgaattt gccgaagata tctttttaaa      120

tggatgctaa aattcctgaa gttcagctgc atacagtttg cacttatgga ctcctgttgt      180

tgaagttcgt ttttttgttt tcttcttttt ttaaacattc atagctggtc ttatttgtaa      240

agctcacttt acttagaatt agtggcactt gcttttatta gagaatgatt tcaaatgctg      300

taactttctg aaataacatg gccttggagg gcatgaagac agatactcct ccaaggttat      360

tggacaccgg aaacaataaa ttggaacacc tcctcaaacc taccactcag gaatgtttgc      420

tggggccgaa agaacagtcc attgaaaggg agtattacaa aaacatggcc tttgcttgaa      480

agaaaatacc aaggaacagg aaactgatca ttaaagcctg agtttgcttt caaa            534


<210> 46
<211> 5
<212> PRT
<213> Homo sapiens

<400> 46
Lys Ser Ser Lys Cys 
1               5   


<210> 47
<211> 1676
<212> PRT
<213> Homo sapiens

<400> 47
Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Ile Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val His Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210> 48
<211> 1658
<212> PRT
<213> Homo sapiens

<400> 48
Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg Val Gly 
1               5                   10                  15      


Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu Ala Phe 
            20                  25                  30          


Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe Ser Tyr 
        35                  40                  45              


Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln Asn Ser 
    50                  55                  60                  


Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln Asn Pro 
65                  70                  75                  80  


Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser Lys Ser 
                85                  90                  95      


Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile His Thr 
            100                 105                 110         


Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg Val Tyr 
        115                 120                 125             


Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val Leu Thr 
    130                 135                 140                 


Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu Ile Asp 
145                 150                 155                 160 


His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser Asn Pro 
                165                 170                 175     


Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp Phe Ser 
            180                 185                 190         


Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu Pro His 
        195                 200                 205             


Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr Lys Asn 
    210                 215                 220                 


Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr Asn Lys 
225                 230                 235                 240 


Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg Glu Asp 
                245                 250                 255     


Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln Asn Thr 
            260                 265                 270         


Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu Thr Ala 
        275                 280                 285             


Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe Ser Glu 
305                 310                 315                 320 


Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr Lys Leu 
                325                 330                 335     


Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro Tyr Pro 
            340                 345                 350         


Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly Gly Val 
        355                 360                 365             


Pro Val Ile Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu Thr Ser 
    370                 375                 380                 


Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly Val Ala 
385                 390                 395                 400 


Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu Phe Asn 
                405                 410                 415     


Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala Arg Glu 
            420                 425                 430         


Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr Leu Tyr 
        435                 440                 445             


Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu His Leu 
    450                 455                 460                 


Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile Thr His 
465                 470                 475                 480 


Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe Gly Thr 
                485                 490                 495     


Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile Pro Val 
            500                 505                 510         


Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr Ile Val 
        515                 520                 525             


Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp Leu Asn 
    530                 535                 540                 


Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser Pro Asp 
545                 550                 555                 560 


Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met Ala Thr 
                565                 570                 575     


Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala Val Tyr 
            580                 585                 590         


Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe Gln Phe 
        595                 600                 605             


Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu Asn Asn 
    610                 615                 620                 


Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn Ala Asn 
625                 630                 635                 640 


Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile Leu Arg 
                645                 650                 655     


Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr 
            660                 665                 670         


Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn 
        675                 680                 685             


Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro 
    690                 695                 700                 


Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu 
705                 710                 715                 720 


Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu His Met 
                725                 730                 735     


Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr Phe Pro 
            740                 745                 750         


Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys Gln Leu 
        755                 760                 765             


Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln Gly Ile 
    770                 775                 780                 


Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys Ala Lys 
785                 790                 795                 800 


Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser Val Val 
                805                 810                 815     


Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr Arg Thr 
            820                 825                 830         


Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly Ile Cys 
        835                 840                 845             


Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser Ser Lys 
    850                 855                 860                 


Cys Val His Gln Lys Val Glu Gly Ser Ser Ser His Leu Val Thr Phe 
865                 870                 875                 880 


Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe Ser Leu 
                885                 890                 895     


Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg Val Val 
            900                 905                 910         


Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu Asp Pro 
        915                 920                 925             


Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro Tyr Arg 
    930                 935                 940                 


Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile Leu Ser 
945                 950                 955                 960 


Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu Ser Gln 
                965                 970                 975     


Glu Gly Ile Asn Ile Leu Thr His Leu Pro Lys Gly Ser Ala Glu Ala 
            980                 985                 990         


Glu Leu Met Ser Val Val Pro Val  Phe Tyr Val Phe His  Tyr Leu Glu 
        995                 1000                 1005             


Thr Gly  Asn His Trp Asn Ile  Phe His Ser Asp Pro  Leu Ile Glu 
    1010                 1015                 1020             


Lys Gln  Lys Leu Lys Lys Lys  Leu Lys Glu Gly Met  Leu Ser Ile 
    1025                 1030                 1035             


Met Ser  Tyr Arg Asn Ala Asp  Tyr Ser Tyr Ser Val  Trp Lys Gly 
    1040                 1045                 1050             


Gly Ser  Ala Ser Thr Trp Leu  Thr Ala Phe Ala Leu  Arg Val Leu 
    1055                 1060                 1065             


Gly Gln  Val Asn Lys Tyr Val  Glu Gln Asn Gln Asn  Ser Ile Cys 
    1070                 1075                 1080             


Asn Ser  Leu Leu Trp Leu Val  Glu Asn Tyr Gln Leu  Asp Asn Gly 
    1085                 1090                 1095             


Ser Phe  Lys Glu Asn Ser Gln  Tyr Gln Pro Ile Lys  Leu Gln Gly 
    1100                 1105                 1110             


Thr Leu  Pro Val Glu Ala Arg  Glu Asn Ser Leu Tyr  Leu Thr Ala 
    1115                 1120                 1125             


Phe Thr  Val Ile Gly Ile Arg  Lys Ala Phe Asp Ile  Cys Pro Leu 
    1130                 1135                 1140             


Val Lys  Ile Asp Thr Ala Leu  Ile Lys Ala Asp Asn  Phe Leu Leu 
    1145                 1150                 1155             


Glu Asn  Thr Leu Pro Ala Gln  Ser Thr Phe Thr Leu  Ala Ile Ser 
    1160                 1165                 1170             


Ala Tyr  Ala Leu Ser Leu Gly  Asp Lys Thr His Pro  Gln Phe Arg 
    1175                 1180                 1185             


Ser Ile  Val Ser Ala Leu Lys  Arg Glu Ala Leu Val  Lys Gly Asn 
    1190                 1195                 1200             


Pro Pro  Ile Tyr Arg Phe Trp  Lys Asp Asn Leu Gln  His Lys Asp 
    1205                 1210                 1215             


Ser Ser  Val Pro Asn Thr Gly  Thr Ala Arg Met Val  Glu Thr Thr 
    1220                 1225                 1230             


Ala Tyr  Ala Leu Leu Thr Ser  Leu Asn Leu Lys Asp  Ile Asn Tyr 
    1235                 1240                 1245             


Val Asn  Pro Val Ile Lys Trp  Leu Ser Glu Glu Gln  Arg Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Phe Tyr Ser Thr Gln  Asp Thr Ile Asn Ala  Ile Glu Gly 
    1265                 1270                 1275             


Leu Thr  Glu Tyr Ser Leu Leu  Val Lys Gln Leu Arg  Leu Ser Met 
    1280                 1285                 1290             


Asp Ile  Asp Val Ser Tyr Lys  His Lys Gly Ala Leu  His Asn Tyr 
    1295                 1300                 1305             


Lys Met  Thr Asp Lys Asn Phe  Leu Gly Arg Pro Val  Glu Val Leu 
    1310                 1315                 1320             


Leu Asn  Asp Asp Leu Ile Val  Ser Thr Gly Phe Gly  Ser Gly Leu 
    1325                 1330                 1335             


Ala Thr  Val His Val Thr Thr  Val Val His Lys Thr  Ser Thr Ser 
    1340                 1345                 1350             


Glu Glu  Val Cys Ser Phe Tyr  Leu Lys Ile Asp Thr  Gln Asp Ile 
    1355                 1360                 1365             


Glu Ala  Ser His Tyr Arg Gly  Tyr Gly Asn Ser Asp  Tyr Lys Arg 
    1370                 1375                 1380             


Ile Val  Ala Cys Ala Ser Tyr  Lys Pro Ser Arg Glu  Glu Ser Ser 
    1385                 1390                 1395             


Ser Gly  Ser Ser His Ala Val  Met Asp Ile Ser Leu  Pro Thr Gly 
    1400                 1405                 1410             


Ile Ser  Ala Asn Glu Glu Asp  Leu Lys Ala Leu Val  Glu Gly Val 
    1415                 1420                 1425             


Asp Gln  Leu Phe Thr Asp Tyr  Gln Ile Lys Asp Gly  His Val Ile 
    1430                 1435                 1440             


Leu Gln  Leu Asn Ser Ile Pro  Ser Ser Asp Phe Leu  Cys Val Arg 
    1445                 1450                 1455             


Phe Arg  Ile Phe Glu Leu Phe  Glu Val Gly Phe Leu  Ser Pro Ala 
    1460                 1465                 1470             


Thr Phe  Thr Val Tyr Glu Tyr  His Arg Pro Asp Lys  Gln Cys Thr 
    1475                 1480                 1485             


Met Phe  Tyr Ser Thr Ser Asn  Ile Lys Ile Gln Lys  Val Cys Glu 
    1490                 1495                 1500             


Gly Ala  Ala Cys Lys Cys Val  Glu Ala Asp Cys Gly  Gln Met Gln 
    1505                 1510                 1515             


Glu Glu  Leu Asp Leu Thr Ile  Ser Ala Glu Thr Arg  Lys Gln Thr 
    1520                 1525                 1530             


Ala Cys  Lys Pro Glu Ile Ala  Tyr Ala Tyr Lys Val  Ser Ile Thr 
    1535                 1540                 1545             


Ser Ile  Thr Val Glu Asn Val  Phe Val Lys Tyr Lys  Ala Thr Leu 
    1550                 1555                 1560             


Leu Asp  Ile Tyr Lys Thr Gly  Glu Ala Val Ala Glu  Lys Asp Ser 
    1565                 1570                 1575             


Glu Ile  Thr Phe Ile Lys Lys  Val Thr Cys Thr Asn  Ala Glu Leu 
    1580                 1585                 1590             


Val Lys  Gly Arg Gln Tyr Leu  Ile Met Gly Lys Glu  Ala Leu Gln 
    1595                 1600                 1605             


Ile Lys  Tyr Asn Phe Ser Phe  Arg Tyr Ile Tyr Pro  Leu Asp Ser 
    1610                 1615                 1620             


Leu Thr  Trp Ile Glu Tyr Trp  Pro Arg Asp Thr Thr  Cys Ser Ser 
    1625                 1630                 1635             


Cys Gln  Ala Phe Leu Ala Asn  Leu Asp Glu Phe Ala  Glu Asp Ile 
    1640                 1645                 1650             


Phe Leu  Asn Gly Cys 
    1655             


