                         SEQUENCE LISTING

<110>  DiMarchi, Richard
 
<120>  INSULIN ANALOG DIMERS

<130>  32993-216351

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  4
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  5
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Met Tyr Cys Ala 
            20      


<210>  6
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
1               5                   10                  15      


Glu Thr Tyr Cys Ala 
            20      


<210>  8
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


<210>  9
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is ornithine, lysine, arginine or lysine analog

<400>  9

Gly Tyr Gly Ser Ser Ser Arg Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  10
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  13
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu His Gly Phe Phe Tyr Thr Pro Arg 
            20                  25                  


<210>  14
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is ornithine, lysine, arginine or a lysine 
       analog

<400>  15

Gly Ala Gly Ser Ser Ser Arg Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position1 is glycine, alanine, valine, leucine, 
       isoleucine, proline, phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaas at positions 7 and 8 are independently arginine, lysine, 
       cysteine, homocysteine, acetyl-phenylalanine or ornithine

<400>  16

Xaa Xaa Gly Ser Ser Ser Xaa Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position1 is glycine, alanine, valine, leucine, 
       isoleucine, proline, phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaas at positions 7 and 8 are independently arginine, lysine or 
       ornithine or a lysine analog

<400>  17

Xaa Xaa Gly Ser Ser Ser Xaa Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  18
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is arginine or lysine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is arginine or lysine

<400>  18

Ser Ser Ser Ser Xaa Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Xaa 
            20                  25                  


<210>  19
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is arginine or lysine

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is arginine or lysine

<400>  19

Met Gly Ser Ser Ser Ser Xaa Ala Pro Pro Pro Ser Leu Pro Ser Pro 
1               5                   10                  15      


Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Glu Glu 
            20                  25                  30          


Glu Glu Glu Xaa 
        35      


<210>  20
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu His Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  21
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Tyr Gly Ser Ser Ser Arg Lys Ala Pro Gln Thr 
1               5                   10          


<210>  22
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  23
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  23

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe 
            20                  25  


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  26
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  27

Gly Ala Gly Ser Ser Ser Arg Arg 
1               5               


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  28

Gly Ala Gly Ser Ser Ser Arg Arg Ala 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  29

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  30

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln 
1               5                   10      


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  31

Pro Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  32

Pro Ala Gly Ser Ser Ser Arg Arg 
1               5               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  33

Pro Ala Gly Ser Ser Ser Arg Arg Ala 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  34

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro 
1               5                   10  


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  35

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln 
1               5                   10      


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  36

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  37
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  37

Tyr Thr Pro Lys 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe Asn Lys Pro 
1               


<210>  39
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Thr Pro Lys Thr 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Phe Asn Lys Pro Thr 
1               5   


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is serine or alanine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is alanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is arginine or ornithine

<400>  41

Gly Pro Glu Thr Leu Cys Gly Xaa Glu Leu Val Asp Xaa Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  42
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Glu Glu Glu Glu Glu Trp Phe Val Asn Gln His Leu Cys Gly Ser 
1               5                   10                  15      


His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe 
            20                  25                  30          


Tyr Thr Pro Arg 
        35      


<210>  43
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is alanine lysine, ornithine or arginine

<400>  43

Gly Glu Glu Glu Glu Glu Lys Gly Pro Glu His Leu Cys Gly Ala His 
1               5                   10                  15      


Leu Val Asp Ala Leu Tyr Leu Val Cys Gly Asp Xaa Gly Phe Tyr 
            20                  25                  30      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid, glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or 4-amino-phenylalanine

<400>  44

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa 
            20      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is isoleucine or serine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is aspartic acid or serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  45

Gly Ile Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Xaa Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa 
            20      


<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Tyr Arg Pro Ser Glu 
1               5       


<210>  47
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  47

Phe Val Asn Gln 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Gly Pro Glu 
1               


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is asparagine or glycine

<400>  49

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Xaa Asn Xaa Cys Xaa 
            20      


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or phenylalnine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, lysine, ornithine or alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is arginine, lysine, ornithine or alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is arginine, lysine, ornithine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  50

Gly Ile Val Asp Glu Cys Cys Xaa Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa 
            20      


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  51

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  52
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position 19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  52

Gly Ile Val Asp Glu Cys Cys His Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Met Xaa Cys Xaa 
            20      


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  53

Xaa Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  54
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF B chain


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  The Xaa at position 18 is ornithine, lysine or arginine

<400>  54

His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  55
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  55

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr 
            20                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  56

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Pro Lys Thr 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  57

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  The Xaa at position 7 is arginine, lysine or ornithine

<400>  58

Gly Tyr Gly Ser Ser Ser Xaa Arg 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is ornithine

<400>  59

Gly Tyr Gly Ser Ser Ser Xaa Arg 
1               5               


<210>  60
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  The Xaa at position 18 is ornithine

<400>  60

His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  61
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21is ornithine

<400>  61

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr 
            20                  


<210>  62
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine

<400>  62

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Pro Lys Thr 
            20                  25                  


<210>  63
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is ornithine

<400>  63

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  64
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  The Xaa at position 9 is ornithine

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  The Xaas at positions 14 and 15 are both ornithine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  The Xaa at position 19 is tyrosine, 4-methoxy-phenylalanine or 
       4-amino phenylalanine

<400>  64

Gly Ile Val Asp Glu Cys Cys His Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Gln Met Xaa Cys Asn 
            20      


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  65

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  66
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is phenylalanine and desamino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  66

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr 
            20                  25          


<210>  67
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  The Xaa at position 6 is histidine, aspartic acid, glutamic acid,
       homocysteic acid or cysteic acid

<400>  67

His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  68
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position 19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  68

Gly Ile Val Xaa Glu Cys Cys Xaa Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa 
            20      


<210>  69
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid, glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is tyrosine or 4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine, phenylalanine or 
       4-amino-phenylalanine

<400>  69

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Xaa Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa 
            20      


<210>  70
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is isoleucine or serine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is aspartic acid or serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  70

Gly Ile Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Xaa Leu Xaa Xaa Leu 
1               5                   10                  15      


Glu Xaa Xaa Cys Xaa 
            20      


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(7)
<223>  Xaa at positions 2-7 are independently glutamic acid or aspartic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  any or all of amino acids at positions 3-7 are present or absent

<400>  71

Gly Xaa Xaa Xaa Xaa Xaa Xaa Lys 
1               5               


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide for testing cleavage of dipeptide prodrug 
       element

<400>  72

His Ser Arg Gly Thr Phe 
1               5       


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide for testing cleavage of dipeptide prodrug 
       element


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Sarcosine

<400>  73

Lys Xaa His Ser Thr Gly Thr Phe 
1               5               


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is d-histidine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is d-threonine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is d-arginine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is d-threonine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa at position 6 is d-phenylalanine

<400>  74

Xaa Xaa Xaa Gly Xaa Xaa 
1               5       


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is d-lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is d-sarcosine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is d-histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa at position 4 is d-threonine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is d-arginine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa at position 7 is d-threonine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa at position 8 is d-phenylalanine

<400>  75

Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa 
1               5               


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide for testing cleavage of dipeptide prodrug 
       element


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  The Xaa at position 1 is histidine, d-histidine or 
       N-methyl-histdine

<400>  76

Xaa Ser Arg Gly Thr Phe 
1               5       


<210>  77
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  


<210>  78
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  


<210>  79
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  79

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  80
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


<210>  81
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, ornithine, lysine or alanine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine or asparagine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine or asparagine

<400>  81

Gly Ile Val Asp Glu Cys Cys Xaa Xaa Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Xaa Tyr Cys Xaa 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine or arginine

<400>  82

Xaa Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  83
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or phenylalanine

<400>  83

Gly Ile Val Asp Glu Cys Cys Xaa Arg Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  84
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  84

His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Tyr 
            20      


<210>  85
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  85

His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  86
<211>  70
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa at position 60 is 4-amino phenylalanine

<400>  86

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Xaa Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  87
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


<210>  88
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is arginine or lysine

<400>  88

Thr Pro Ala Xaa Ser Glu Gly Ile Val Glu Glu Cys Cys Phe Arg Ser 
1               5                   10                  15      


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala 
            20                  25          


<210>  89
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  


<210>  90
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  90

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  25          


<210>  91
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  91

Cys Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp 
1               5                   10                  15      


Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  25              


<210>  92
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  92

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  25          


<210>  93
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  93

Cys Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp 
1               5                   10                  15      


Thr Leu Tyr Leu Val Cys Gly Asp Arg Gly Phe Tyr 
            20                  25              


<210>  94
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  94

Cys Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30      


<210>  95
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  95

Cys Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  30  


<210>  96
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  96

Cys Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln 
1               5                   10                  15      


Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  30  


<210>  97
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  97

Cys Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Asp Arg Gly Phe Tyr Asn Lys Pro Thr 
            20                  25                  


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is ornithine, lysine, arginine or a lysine 
       analog

<400>  98

Ser Arg Val Ser Arg Xaa Ser Arg 
1               5               


<210>  99
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is a lysine analog

<400>  99

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Xaa Pro Thr 
            20                  25                  


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is ornithine, lysine, arginine or a lysine 
       analog

<400>  100

Gly Tyr Gly Ser Ser Ser Arg Xaa 
1               5               


<210>  101
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is phenylanine or desamino-phenylaalanine

<400>  101

Xaa Val Asn Gln 
1               


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Xaa at positions 1, 2,  and 3 are independently glutamic acid or 
       aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is arginine, glutamic acid or aspartic acid

<400>  102

Xaa Xaa Xaa Xaa Lys 
1               5   


<210>  103
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  103

Thr Pro Ala Lys Ser Glu Gly Ile Val Glu Glu Cys Cys Phe Arg Ser 
1               5                   10                  15      


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala 
            20                  25          


