                         SEQUENCE LISTING

<110>  Institut Pasteur
       SANSONETTI,  Philippe J.
       NIGRO, Giulia
 
<120>  A NOD2 dependent pathway of cytoprotection of stem cells

<130>  B10046A CA/CS

<150>  EP 12 306 208.5
<151>  2012-10-03

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Glu Glu Gly Gly Ser Ala Ser His Asp Glu Glu Glu Arg Ala 
1               5                   10                  15      


Ser Val Leu Leu Gly His Ser Pro Gly Cys Glu Met Cys Ser Gln Glu 
            20                  25                  30          


Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu Leu Leu Val Ser Gly 
        35                  40                  45              


Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp Leu Leu Ser Trp Glu 
    50                  55                  60                  


Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr Val Trp Asn Lys Gly 
                85                  90                  95      


Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala Gln Glu Ala Gln Ala 
            100                 105                 110         


Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp Asp Pro His Ser Leu 
        115                 120                 125             


His Pro Ala Arg Asp Leu Gln Ser His Arg Pro Ala Ile Val Arg Arg 
    130                 135                 140                 


Leu His Ser His Val Glu Asn Met Leu Asp Leu Ala Trp Glu Arg Gly 
145                 150                 155                 160 


Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg Leu Pro Ile Phe Thr 
                165                 170                 175     


Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val Gln Glu Leu Pro Val 
        195                 200                 205             


Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys Lys Lys Tyr Met Ala 
    210                 215                 220                 


Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg Phe Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile Tyr Thr Glu Asn Val 
                245                 250                 255     


Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly Pro Pro Gln Lys Ser 
            260                 265                 270         


Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser Thr Pro Gly His Leu 
        275                 280                 285             


Asn Asp Asp Ala Asp Thr Val Leu Val Val Gly Glu Ala Gly Ser Gly 
    290                 295                 300                 


Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu Trp Ala Ala Gly Gln 
305                 310                 315                 320 


Asp Phe Gln Glu Phe Leu Phe Val Phe Pro Phe Ser Cys Arg Gln Leu 
                325                 330                 335     


Gln Cys Met Ala Lys Pro Leu Ser Val Arg Thr Leu Leu Phe Glu His 
            340                 345                 350         


Cys Cys Trp Pro Asp Val Gly Gln Glu Asp Ile Phe Gln Leu Leu Leu 
        355                 360                 365             


Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp Gly Phe Asp Glu Phe 
    370                 375                 380                 


Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys Ser Pro Thr Asp Pro 
385                 390                 395                 400 


Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu Gln Gly Asn Leu Leu 
                405                 410                 415     


Lys Asn Ala Arg Lys Val Val Thr Ser Arg Pro Ala Ala Val Ser Ala 
            420                 425                 430         


Phe Leu Arg Lys Tyr Ile Arg Thr Glu Phe Asn Leu Lys Gly Phe Ser 
        435                 440                 445             


Glu Gln Gly Ile Glu Leu Tyr Leu Arg Lys Arg His His Glu Pro Gly 
    450                 455                 460                 


Val Ala Asp Arg Leu Ile Arg Leu Leu Gln Glu Thr Ser Ala Leu His 
465                 470                 475                 480 


Gly Leu Cys His Leu Pro Val Phe Ser Trp Met Val Ser Lys Cys His 
                485                 490                 495     


Gln Glu Leu Leu Leu Gln Glu Gly Gly Ser Pro Lys Thr Thr Thr Asp 
            500                 505                 510         


Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu His Ala Thr Pro Pro 
        515                 520                 525             


Asp Ser Ala Ser Gln Gly Leu Gly Pro Ser Leu Leu Arg Gly Arg Leu 
    530                 535                 540                 


Pro Thr Leu Leu His Leu Gly Arg Leu Ala Leu Trp Gly Leu Gly Met 
545                 550                 555                 560 


Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val Ser 
                565                 570                 575     


Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val Val 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln Cys 
        595                 600                 605             


Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro Ala 
    610                 615                 620                 


Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro Met 
625                 630                 635                 640 


Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys Asp 
                645                 650                 655     


Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu Gln 
            660                 665                 670         


Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp Gly 
        675                 680                 685             


Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg Gln 
    690                 695                 700                 


Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe His 
705                 710                 715                 720 


Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala Met 
                725                 730                 735     


Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu Glu 
            740                 745                 750         


Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu Lys 
        755                 760                 765             


Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala Phe 
    770                 775                 780                 


Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr Asn 
785                 790                 795                 800 


Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly Val 
                805                 810                 815     


Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly Ile 
            820                 825                 830         


Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys Leu 
        835                 840                 845             


Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met Ala 
    850                 855                 860                 


Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Leu Gly Asn 
865                 870                 875                 880 


Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu Gly Leu Arg 
                885                 890                 895     


Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn Arg Val Gly 
            900                 905                 910         


Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp His Gln Ser 
        915                 920                 925             


Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser Val Gly Ala 
    930                 935                 940                 


Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu Glu Glu Leu 
945                 950                 955                 960 


Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys Ser Leu Ala 
                965                 970                 975     


Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys Leu Ser Asn 
            980                 985                 990         


Asn Cys Ile Thr Tyr Leu Gly Ala  Glu Ala Leu Leu Gln  Ala Leu Glu 
        995                 1000                 1005             


Arg Asn  Asp Thr Ile Leu Glu  Val Trp Leu Arg Gly  Asn Thr Phe 
    1010                 1015                 1020             


Ser Leu  Glu Glu Val Asp Lys  Leu Gly Cys Arg Asp  Thr Arg Leu 
    1025                 1030                 1035             


Leu Leu  
    1040 


<210>  2
<211>  1013
<212>  PRT
<213>  Mus musculus

<400>  2

Met Cys Ser Gln Glu Glu Phe Gln Ala Gln Arg Ser Gln Leu Val Ala 
1               5                   10                  15      


Leu Leu Ile Ser Gly Ser Leu Glu Gly Phe Glu Ser Ile Leu Asp Trp 
            20                  25                  30          


Leu Leu Ser Trp Asp Val Leu Ser Arg Glu Asp Tyr Glu Gly Leu Ser 
        35                  40                  45              


Leu Pro Gly Gln Pro Leu Ser His Ser Ala Arg Arg Leu Leu Asp Thr 
    50                  55                  60                  


Val Trp Asn Lys Gly Val Trp Gly Cys Gln Lys Leu Leu Glu Ala Val 
65                  70                  75                  80  


Gln Glu Ala Gln Ala Asn Ser His Thr Phe Glu Leu Tyr Gly Ser Trp 
                85                  90                  95      


Asp Thr His Ser Leu His Pro Thr Arg Asp Leu Gln Ser His Arg Pro 
            100                 105                 110         


Ala Ile Val Arg Arg Leu Tyr Asn His Val Glu Ala Met Leu Glu Leu 
        115                 120                 125             


Ala Arg Glu Gly Gly Phe Leu Ser Gln Tyr Glu Cys Glu Glu Ile Arg 
    130                 135                 140                 


Leu Pro Ile Phe Thr Ser Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Ala Ala Val Lys Ala Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val 
                165                 170                 175     


Arg Glu Leu Pro Ala Pro Leu Pro Leu Pro Tyr Glu Ala Ala Glu Cys 
            180                 185                 190         


Gln Lys Phe Ile Ser Lys Leu Arg Thr Met Val Leu Ala Gln Ser Arg 
        195                 200                 205             


Phe Leu Ser Thr Tyr Asp Gly Ser Glu Asn Leu Cys Leu Glu Asp Ile 
    210                 215                 220                 


Tyr Thr Glu Asn Ile Leu Glu Leu Arg Thr Glu Val Gly Thr Ala Gly 
225                 230                 235                 240 


Ala Leu Gln Lys Ser Pro Ala Ile Leu Gly Leu Glu Asp Leu Phe Asp 
                245                 250                 255     


Thr His Gly His Leu Asn Arg Asp Ala Asp Thr Ile Leu Val Val Gly 
            260                 265                 270         


Glu Ala Gly Ser Gly Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu 
        275                 280                 285             


Trp Ala Thr Gly Arg Ser Phe Gln Glu Phe Leu Phe Ile Phe Pro Phe 
    290                 295                 300                 


Ser Cys Arg Gln Leu Gln Cys Val Ala Lys Pro Leu Ser Leu Arg Thr 
305                 310                 315                 320 


Leu Leu Phe Glu His Cys Cys Trp Pro Asp Val Ala Gln Asp Asp Val 
                325                 330                 335     


Phe Gln Phe Leu Leu Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp 
            340                 345                 350         


Gly Leu Asp Glu Phe Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys 
        355                 360                 365             


Ser Pro Ile Asp Pro Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu 
    370                 375                 380                 


Gln Gly Asn Leu Leu Lys Asn Ala Cys Lys Val Leu Thr Ser Arg Pro 
385                 390                 395                 400 


Asp Ala Val Ser Ala Leu Leu Arg Lys Phe Val Arg Thr Glu Cys Gln 
                405                 410                 415     


Leu Lys Gly Phe Ser Glu Glu Gly Ile Gln Leu Tyr Leu Arg Lys His 
            420                 425                 430         


His Arg Glu Pro Gly Val Ala Asp Arg Leu Ile Gln Leu Ile Gln Ala 
        435                 440                 445             


Thr Ser Ala Leu His Gly Leu Cys His Leu Pro Val Phe Ser Trp Met 
    450                 455                 460                 


Val Ser Arg Cys His Arg Glu Leu Leu Leu Gln Asn Arg Gly Phe Pro 
465                 470                 475                 480 


Thr Thr Ser Thr Asp Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu 
                485                 490                 495     


His Ala Ser Pro Pro Asp Ser Ser Pro Leu Gly Leu Gly Pro Gly Leu 
            500                 505                 510         


Leu Gln Ser Arg Leu Ser Thr Leu Leu His Leu Gly His Leu Ala Leu 
        515                 520                 525             


Arg Gly Leu Ala Met Ser Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln 
    530                 535                 540                 


Ala Ala Gln Val Asp Ser Asp Asp Ile Ser Leu Gly Phe Leu Val Arg 
545                 550                 555                 560 


Ala Gln Ser Ser Val Pro Gly Ser Lys Ala Pro Leu Glu Phe Leu His 
                565                 570                 575     


Ile Thr Phe Gln Cys Phe Phe Ala Ala Phe Tyr Leu Ala Val Ser Ala 
            580                 585                 590         


Asp Thr Ser Val Ala Ser Leu Lys His Leu Phe Ser Cys Gly Arg Leu 
        595                 600                 605             


Gly Ser Ser Leu Leu Gly Arg Leu Leu Pro Asn Leu Cys Ile Gln Gly 
    610                 615                 620                 


Ser Arg Val Lys Lys Gly Ser Glu Ala Ala Leu Leu Gln Lys Ala Glu 
625                 630                 635                 640 


Pro His Asn Leu Gln Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser 
                645                 650                 655     


Gln Gln His Arg Asp Leu Leu Ala Ala Cys Gln Ile Ser Glu Arg Val 
            660                 665                 670         


Leu Leu Gln Arg Gln Ala Arg Ala Arg Ser Cys Leu Ala His Ser Leu 
        675                 680                 685             


Arg Glu His Phe His Ser Ile Pro Pro Ala Val Pro Gly Glu Thr Lys 
    690                 695                 700                 


Ser Met His Ala Met Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr 
705                 710                 715                 720 


Glu Met Gln Glu Glu Gln Leu Ala Gln Glu Ala Val Arg Arg Leu Asp 
                725                 730                 735     


Ile Gly His Leu Lys Leu Thr Phe Cys Arg Val Gly Pro Ala Glu Cys 
            740                 745                 750         


Ala Ala Leu Ala Phe Val Leu Gln His Leu Gln Arg Pro Val Ala Leu 
        755                 760                 765             


Gln Leu Asp Tyr Asn Ser Val Gly Asp Val Gly Val Glu Gln Leu Arg 
    770                 775                 780                 


Pro Cys Leu Gly Val Cys Thr Ala Leu Tyr Leu Arg Asp Asn Asn Ile 
785                 790                 795                 800 


Ser Asp Arg Gly Ala Arg Thr Leu Val Glu Cys Ala Leu Arg Cys Glu 
                805                 810                 815     


Gln Leu Gln Lys Leu Ala Leu Phe Asn Asn Lys Leu Thr Asp Ala Cys 
            820                 825                 830         


Ala Cys Ser Met Ala Lys Leu Leu Ala His Lys Gln Asn Phe Leu Ser 
        835                 840                 845             


Leu Arg Val Gly Asn Asn His Ile Thr Ala Ala Gly Ala Glu Val Leu 
    850                 855                 860                 


Ala Gln Gly Leu Lys Ser Asn Thr Ser Leu Lys Phe Leu Gly Phe Trp 
865                 870                 875                 880 


Gly Asn Ser Val Gly Asp Lys Gly Thr Gln Ala Leu Ala Glu Val Val 
                885                 890                 895     


Ala Asp His Gln Asn Leu Lys Trp Leu Ser Leu Val Gly Asn Asn Ile 
            900                 905                 910         


Gly Ser Met Gly Ala Gln Ala Leu Ala Leu Met Leu Glu Lys Asn Lys 
        915                 920                 925             


Ser Leu Glu Glu Leu Cys Leu Glu Glu Asn His Ile Cys Asp Glu Gly 
    930                 935                 940                 


Val Tyr Ser Leu Ala Glu Gly Leu Lys Arg Asn Ser Thr Leu Lys Phe 
945                 950                 955                 960 


Leu Lys Leu Ser Asn Asn Gly Ile Thr Tyr Arg Gly Ala Glu Ala Leu 
                965                 970                 975     


Leu Gln Ala Leu Ser Arg Asn Ser Ala Ile Leu Glu Val Trp Leu Arg 
            980                 985                 990         


Gly Asn Thr Phe Ser Leu Glu Glu  Ile Gln Thr Leu Ser  Ser Arg Asp 
        995                 1000                 1005             


Ala Arg  Leu Leu Leu 
    1010             


<210>  3
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  3
aagcacacct tgactggtac g                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  4
aagtggacgt ttgcaccttc a                                               21


<210>  5
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  5
tcagtcgtca gcatggctcg c                                               21


<210>  6
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  6
ctccggtggg tggcgtgagt at                                              22


<210>  7
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  7
cgagcttagc agatctccac t                                               21


<210>  8
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  8
ggatttgggg aagcagaaat                                                 20


<210>  9
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  9
aagagactaa aactgaggag cagc                                            24


<210>  10
<211>  17
<212>  DNA
<213>  Mus musculus

<400>  10
cgacagcaga gcgtgta                                                    17


<210>  11
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  11
gacaatgctc tcacagac                                                   18


<210>  12
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  12
ggagtggatt ctattattat gg                                              22


<210>  13
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  13
gagaccgaag caccgactat g                                               21


<210>  14
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  14
cggttttgac attgtgttcg c                                               21


<210>  15
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  15
ggagtggaac agctgcgacc g                                               21


<210>  16
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  16
gcacactcaa ccagcgtgcg                                                 20


<210>  17
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  17
tgggcagaag gtgggactgt gt                                              22


<210>  18
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  18
cgggaaaggc ggtatccggc                                                 20


