                         SEQUENCE LISTING

<110>  NVH Medicinal
 
<120>  Protines recombinantes drives du collagne  activit de 
       liaison au facteur Willebrand

<130>  364053D29804

<150>  FR 1259996
<151>  19 octobre 2012

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Squence drive du collagne


<220>
<221>  CDS
<222>  (1)..(552)

<220>
<221>  sig_peptide
<222>  (1)..(69)

<400>  1
atg atg agc ttc gtg cag aag ggg agc tgg ctg ctt ctc gct ctg ctt         48
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu           
1               5                   10                  15                

cat cct act att atc ctg gca cag ggg cgc ccc gga gct cct gga gag         96
His Pro Thr Ile Ile Leu Ala Gln Gly Arg Pro Gly Ala Pro Gly Glu           
            20                  25                  30                    

aga gga ttg cct gga cct cca ggg ccc aga gga gct gct gga gaa cct        144
Arg Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Ala Ala Gly Glu Pro           
        35                  40                  45                        

ggc aga gat ggc gtc cct gga gga cca gga atg agg ggc atg ccc gga        192
Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly           
    50                  55                  60                            

agc cca gga gga cca gga agc gat ggg aag cca ggg cct ccc gga agc        240
Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser           
65                  70                  75                  80            

cag gga gaa agc ggc aga cca gga cct cct gga gag aac gga ttc cct        288
Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro           
                85                  90                  95                

gga gaa agg ggg gat gca ggc gct cct ggg gca cca gga cct cgt ggc        336
Gly Glu Arg Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly           
            100                 105                 110                   

cag ccc ggg gtg atg gga ttc ccc ggg gat gcc ggg gca cct ggt gca        384
Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala           
        115                 120                 125                       

cct ggc cca cgt ggg cag cct gga gtc atg ggg ttc cct gga cca cct        432
Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Pro           
    130                 135                 140                           

ggc cca cca ggc cct ccc gga cca cct gga cct cca ggc cct cct ggc        480
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly           
145                 150                 155                 160           

cct cct gga cct cct gga cca cct gga cct cca ggc cca aga ggc gac        528
Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Asp           
                165                 170                 175               

aag gga cct cct gga cct gga tct                                        552
Lys Gly Pro Pro Gly Pro Gly Ser                                           
            180                                                           


<210>  2
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence drive du collagne

<400>  2

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gly Arg Pro Gly Ala Pro Gly Glu 
            20                  25                  30          


Arg Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Ala Ala Gly Glu Pro 
        35                  40                  45              


Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly 
    50                  55                  60                  


Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser 
65                  70                  75                  80  


Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro 
                85                  90                  95      


Gly Glu Arg Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala 
        115                 120                 125             


Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Asp 
                165                 170                 175     


Lys Gly Pro Pro Gly Pro Gly Ser 
            180                 


<210>  3
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence drive du collagne


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  3

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gly Arg Pro Gly Ala Pro Gly Glu 
            20                  25                  30          


Arg Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Ala Ala Gly Glu Pro 
        35                  40                  45              


Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly 
    50                  55                  60                  


Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser 
65                  70                  75                  80  


Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro 
                85                  90                  95      


Gly Glu Arg Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Gly Val Met Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Pro 
        115                 120                 125             


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Asp Lys Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gly Ser 
            


<210>  4
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence drive du collagne


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  4

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gly Arg Pro Gly Ala Pro Gly Glu 
            20                  25                  30          


Arg Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Ala Ala Gly Glu Pro 
        35                  40                  45              


Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly 
    50                  55                  60                  


Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser 
65                  70                  75                  80  


Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro 
                85                  90                  95      


Gly Glu Arg Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala 
        115                 120                 125             


Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala 
    130                 135                 140                 


Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly 
145                 150                 155                 160 


Phe Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
                165                 170                 175     


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Pro Arg Gly Asp Lys Gly Pro Pro Gly Pro Gly Ser 
        195                 200                 205 


<210>  5
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Squence drive du collagne


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  5

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gly Arg Pro Gly Ala Pro Gly Glu 
            20                  25                  30          


Arg Gly Leu Pro Gly Pro Pro Gly Pro Arg Gly Ala Ala Gly Glu Pro 
        35                  40                  45              


Gly Arg Asp Gly Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly 
    50                  55                  60                  


Ser Pro Gly Gly Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser 
65                  70                  75                  80  


Gln Gly Glu Ser Gly Arg Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro 
                85                  90                  95      


Gly Glu Arg Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala 
        115                 120                 125             


Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Asp Ala 
    130                 135                 140                 


Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly Gln Pro Gly Val Met Gly 
145                 150                 155                 160 


Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly Gln 
                165                 170                 175     


Pro Gly Val Met Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        195                 200                 205             


Pro Pro Gly Pro Pro Gly Pro Arg Gly Asp Lys Gly Pro Pro Gly Pro 
    210                 215                 220                 


Gly Ser 
225     


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif liaison facteur Willebrand

<400>  6

Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro 
1               5                   10          


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  7

Gly Asp Ala Gly Ala Pro Gly Ala Pro 
1               5                   


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Linker et motif de liaison facteur Willebrand)x2

<400>  8

Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro Arg Gly Gln Pro Gly 
1               5                   10                  15      


Val Met Gly Phe Pro Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Pro 
            20                  25                  30          


Arg Gly Gln Pro Gly Val Met Gly Phe Pro 
        35                  40          


