                         SEQUENCE LISTING

<110>  Ma, Runlin Z
 
<120>  SHON as a prognostic biomarker for cancer and as a predictor of 
       response to endocrine therapy

<130>  SHON

<140>  PCT/NZ2013/000188
<141>  2015-11-13

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  725
<212>  DNA
<213>  Homo sapiens

<400>  1
tgttggtcta gccttgcctc ccgcataccc agtctagagc ctggccacat gcccatcaaa       60

agactctcac tgctctgcct gccttcttct gtcctggcgt ctataccctc agaccagcct      120

tgcataccta ctcctgccag cctcctccag gaagccttgc ctcctcaact ctcctgcacc      180

atcctcacat ttcacctggc cactgtcact gccagaggag gcaccactga cctgcctcat      240

ggcccagcca ctgcacccat ctccaaccag acccttggtg tgttccccac ccaatccatc      300

acaagccact ttcaagcttt agggaagtga aaagtactgc ctgccctcaa aaaaaaaaaa      360

aaaagaaaaa gaaaagaaag gaaaagaaaa gaaaacccag ccgtaataag gagaccttat      420

caggagtact ttacagttta taaagcatgt ttctagccat cattgggacc acacggtggt      480

cagtcattat cattttcatt ttatggatga ggacatcgtg actcaaagag cttggtaacg      540

tgcccagggt catcccacgg gtgagtggaa gggccaggat tcaaaaccag gactccaggt      600

tccaagtgtc aggcccgttc gaccacactg tcctcccacc agccaagagg gcaattctgg      660

aatcagccag gagggctgtc aatcacagga caaataaaat agtctgtttt tacttagctg      720

gaaaa                                                                  725


<210>  2
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ile Lys Arg Leu Ser Leu Leu Cys Leu Pro Ser Ser Val Leu 
1               5                   10                  15      


Ala Ser Ile Pro Ser Asp Gln Pro Cys Ile Pro Thr Pro Ala Ser Leu 
            20                  25                  30          


Leu Gln Glu Ala Leu Pro Pro Gln Leu Ser Cys Thr Ile Leu Thr Phe 
        35                  40                  45              


His Leu Ala Thr Val Thr Ala Arg Gly Gly Thr Thr Asp Leu Pro His 
    50                  55                  60                  


Gly Pro Ala Thr Ala Pro Ile Ser Asn Gln Thr Leu Gly Val Phe Pro 
65                  70                  75                  80  


Thr Gln Ser Ile Thr Ser His Phe Gln Ala Leu Gly Lys 
                85                  90              


<210>  3
<211>  893
<212>  DNA
<213>  Homo sapiens

<400>  3
ccggggcagc cgagggcccc tgactcggct cctcgcggcg acatggatcg gatggccagc       60

tccatgaagc aggtgcccaa cccactgccc aaggtgctga gccggcgcgg ggtcggcgct      120

gggctggagg cggcggagcg cgagagcttc gagcggactc agggtcgctg ttggtctagc      180

cttgcctccc gcatacccag tctagagcct ggccacatgc ccatcaaaag actctcactg      240

ctctgcctgc cttcttctgt cctggcgtct ataccctcag accagccttg catacctact      300

cctgccagcc tcctccagga agccttgcct cctcaactct cctgcaccat cctcacattt      360

cacctggcca ctgtcactgc cagaggaggc accactgacc tgcctcatgg cccagccact      420

gcacccatct ccaaccagac ccttggtgtg ttccccaccc aatccatcac aagccacttt      480

caagctttag ggaagtgaaa agtactgcct gccctcaaaa aaaaaaaaaa aagaaaaaga      540

aaagaaagga aaagaaaaga aaacccagcc gtaataagga gaccttatca ggagtacttt      600

acagtttata aagcatgttt ctagccatca ttgggaccac acggtggtca gtcattatca      660

ttttcatttt atggatgagg acatcgtgac tcaaagagct tggtaacgtg cccagggtca      720

tcccacgggt gagtggaagg gccaggattc aaaaccagga ctccaggttc caagtgtcag      780

gcccgttcga ccacactgtc ctcccaccag ccaagagggc aattctggaa tcagccagga      840

gggctgtcaa tcacaggaca aataaaatag tctgttttta cttagctgga aaa             893


<210>  4
<211>  775
<212>  DNA
<213>  Homo sapiens

<400>  4
ccggggcagc cgagggcccc tgactcggct cctcgcggcg acatggatcg gatggccagc       60

tccatgaagc aggtgcccaa cccactgccc aaggtgctga gccggcgcgg ggtcggcgct      120

gggctggagg cggcggagcg cgagagcttc gagcggactc agaccagcct tgcataccta      180

ctcctgccag cctcctccag gaagccttgc ctcctcaact ctcctgcacc atcctcacat      240

ttcacctggc cactgtcact gccagaggag gcaccactga cctgcctcat ggcccagcca      300

ctgcacccat ctccaaccag acccttggtg tgttccccac ccaatccatc acaagccact      360

ttcaagcttt agggaagtga aaagtactgc ctgccctcaa aaaaaaaaaa aaaagaaaaa      420

gaaaagaaag gaaaagaaaa gaaaacccag ccgtaataag gagaccttat caggagtact      480

ttacagttta taaagcatgt ttctagccat cattgggacc acacggtggt cagtcattat      540

cattttcatt ttatggatga ggacatcgtg actcaaagag cttggtaacg tgcccagggt      600

catcccacgg gtgagtggaa gggccaggat tcaaaaccag gactccaggt tccaagtgtc      660

aggcccgttc gaccacactg tcctcccacc agccaagagg gcaattctgg aatcagccag      720

gagggctgtc aatcacagga caaataaaat agtctgtttt tacttagctg gaaaa           775


<210>  5
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro 
1               5                   10                  15      


Lys Val Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu 
            20                  25                  30          


Arg Glu Ser Phe Glu Arg Thr Gln Gly Arg Cys Trp Ser Ser Leu Ala 
        35                  40                  45              


Ser Arg Ile Pro Ser Leu Glu Pro Gly His Met Pro Ile Lys Arg Leu 
    50                  55                  60                  


Ser Leu Leu Cys Leu Pro Ser Ser Val Leu Ala Ser Ile Pro Ser Asp 
65                  70                  75                  80  


Gln Pro Cys Ile Pro Thr Pro Ala Ser Leu Leu Gln Glu Ala Leu Pro 
                85                  90                  95      


Pro Gln Leu Ser Cys Thr Ile Leu Thr Phe His Leu Ala Thr Val Thr 
            100                 105                 110         


Ala Arg Gly Gly Thr Thr Asp Leu Pro His Gly Pro Ala Thr Ala Pro 
        115                 120                 125             


Ile Ser Asn Gln Thr Leu Gly Val Phe Pro Thr Gln Ser Ile Thr Ser 
    130                 135                 140                 


His Phe Gln Ala Leu Gly Lys 
145                 150     


<210>  6
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro 
1               5                   10                  15      


Lys Val Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu 
            20                  25                  30          


Arg Glu Ser Phe Glu Arg Thr Gln Thr Ser Leu Ala Tyr Leu Leu Leu 
        35                  40                  45              


Pro Ala Ser Ser Arg Lys Pro Cys Leu Leu Asn Ser Pro Ala Pro Ser 
    50                  55                  60                  


Ser His Phe Thr Trp Pro Leu Ser Leu Pro Glu Glu Ala Pro Leu Thr 
65                  70                  75                  80  


Cys Leu Met Ala Gln Pro Leu His Pro Ser Pro Thr Arg Pro Leu Val 
                85                  90                  95      


Cys Ser Pro Pro Asn Pro Ser Gln Ala Thr Phe Lys Leu 
            100                 105                 


<210>  7
<211>  1140
<212>  DNA
<213>  Homo sapiens


<220>
<221>  promoter
<222>  (1)..(959)

<220>
<221>  exon
<222>  (960)..(1121)
<223>  SHON transcripts a/b

<220>
<221>  Intron
<222>  (1122)..(1140)
<223>  Partial intron

<400>  7
taagcatcac acttctctct gcttgctggt accctggctg acgtctgagc aggatgggac       60

gcgcggctca gagcctaaga taaaccgaaa gtgtctacag ggctttctac caacaaataa      120

gctctgacgg gttcctttga tgaggtttgg gaggcaggtc ccgggaggtg cccgcggact      180

cagccccgaa ctccgggacc tgggctctgc gatccttgca gagggcatgg gcaggggcag      240

aatggagaag tgcaggacgg ggaagcctgg gagctgggtg ggggcggcca cccattgagc      300

cggatccggc caggcgccca cgctgcgccc cgcccgcggg gctgcgcttt cccgggctgc      360

ggccgcaggg ctggtcagtc cggcgctccc gggtcccagg cccggaagga gctaacgggc      420

tattcgcagg cgggctggga ttcccccggg ggaggcccca ctgcccggcc cgcgtcatcc      480

ccgcccatct ccacgggccg tcgcgggata gccccctgca ggagcgggca gggtagtggg      540

cggcgcttgg cggagggcag cacgctcggg gcgcgcgggg actgcggccg aggggaggag      600

agggcggtgc gcgggcgggg gcggggcgag cgagggcata tcagggcagc ccgcccaggc      660

cacgccccat ccaggcctcg ccccgtccgc accccgcccc ggccctgcct agaacggcgg      720

gaccacggtg actgacagga ctccagacca gtcaccacgc gcctcgaggc cccgagaggc      780

tagtcggggc cgagccagcg gaggggctcc tgaaggggcg ggggcgggcg gggaagccgt      840

tcggcgaggg gcggggtctc tggaagactg gcagaactca cagccaatgg caggcgggag      900

ccgtcccgtt agcgccggat ccccgcgggt agggcggggc gggcggcgcc gtggggatc       959

ccg ggg cag ccg agg gcc cct gac tcg gct cct cgc ggc gac atg gat       1007
Pro Gly Gln Pro Arg Ala Pro Asp Ser Ala Pro Arg Gly Asp Met Asp           
1               5                   10                  15                

cgg atg gcc agc tcc atg aag cag gtg ccc aac cca ctg ccc aag gtg       1055
Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro Lys Val           
            20                  25                  30                    

ctg agc cgg cgc ggg gtc ggc gct ggg ctg gag gcg gcg gag cgc gag       1103
Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu Arg Glu           
        35                  40                  45                        

agc ttc gag cgg act cag gtgaggacgg gggaccccg                          1140
Ser Phe Glu Arg Thr Gln                                                   
    50                                                                    


<210>  8
<211>  1452
<212>  DNA
<213>  Homo sapiens


<220>
<221>  promoter
<222>  (1)..(721)

<220>
<221>  misc_feature
<222>  (21)..(30)
<223>  3960 bp omitted

<220>
<221>  misc_feature
<222>  (21)..(30)
<223>  Represents the omitted sequences of 3,960 bp long

<220>
<221>  5'UTR
<222>  (722)..(775)

<220>
<221>  3'UTR
<222>  (1057)..(1452)

<220>
<221>  polyA_signal
<222>  (1420)..(1425)

<400>  8
gggcatccct ggggcaccct nnnnnnnnnn cctgggccac aggatatatt aataattact       60

ttatttattt ttatgtaaga gatggtctcg ctctattgtc cagtctggag tgcagtggca      120

ccatcatagc tcagttttgc ctgggactcc tgggctcaag tgatcctcct gccttagcct      180

cctgagtgct gggactacag gagcatgcca ccatgcttag ctgatcttta aaatttattt      240

atttatttat ttatttattt atttatttat ttatttgaga cagagtctca ctctgttgct      300

caggctggag tgcagtggcg ccatctcggt tcactacaac cttcgcctcc tgggttcaag      360

tgattctcct gcctcggcct ctcgagtagc tgggattaca ggcgagcgcc accacgcccg      420

gctaattttt tgtattttta gtagagacag ggtctcactt gttgaccagg ctggcctcga      480

actcctgacc tcaggtgagc cgcctgcctc agcctcccaa agtgctggga ttacaggtat      540

aagccatcgt tcctggccta gaattttttt tgtagagatg gggtcttgct gtgttgccca      600

ggctggtctt gaactcctgg gctcaagcag tcctcccgcc ttggcttccc aaagtgttgg      660

gattacaggt gtgagccgcc gtgcccggcc tataattact tgttttctta taatgctcca      720

gggtcgctgt tggtctagcc ttgcctcccg catacccagt ctagagcctg gccacatgcc      780

catcaaaaga ctctcactgc tctgcctgcc ttcttctgtc ctggcgtcta taccctcaga      840

ccagccttgc atacctactc ctgccagcct cctccaggaa gccttgcctc ctcaactctc      900

ctgcaccatc ctcacatttc acctggccac tgtcactgcc agaggaggca ccactgacct      960

gcctcatggc ccagccactg cacccatctc caaccagacc cttggtgtgt tccccaccca     1020

atccatcaca agccactttc aagctttagg gaagtgaaaa gtactgcctg ccctcaaaaa     1080

aaaaaaaaaa agaaaaagaa aagaaaggaa aagaaaagaa aacccagccg taataaggag     1140

accttatcag gagtacttta cagtttataa agcatgtttc tagccatcat tgggaccaca     1200

cggtggtcag tcattatcat tttcatttta tggatgagga catcgtgact caaagagctt     1260

ggtaacgtgc ccagggtcat cccacgggtg agtggaaggg ccaggattca aaaccaggac     1320

tccaggttcc aagtgtcagg cccgttcgac cacactgtcc tcccaccagc caagagggca     1380

attctggaat cagccaggag ggctgtcaat cacaggacaa ataaaatagt ctgtttttac     1440

ttagctggaa aa                                                         1452


