                         SEQUENCE LISTING

<110>  Novartis Vaccines and Diagnostics, Inc.
 
<120>  Markers for Acute Lymphoblastic Leukemia

<130>  PAT055339-US-PSP

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  7418
<212>  DNA
<213>  Homo sapiens

<400>  1
tgttctaaga acggaagcat ctgggctgga tggaatttag catcaagcag agtccccttt       60

ctgttcagag tgttgtaaag tgcataaaga tgaagcaggc accagaaatc ctcggcagtg      120

ccaacgggaa gactccgagc tgcgaggtga accgcgagtg ttctgtgttc ctcagcaaag      180

cccagctctc cagtagcctg caggaggggg tcatgcagaa gtttaacggc cacgacgccc      240

tgccctttat tccagccgac aagctgaaag atcttacttc ccgggtgttt aatggagaac      300

ccggcgcaca cgatgccaaa ctgcgttttg agtcccagga aatgaaaggg attgggacac      360

cccctaacac tacccctatc aaaaatggct ctccagaaat taagctgaaa atcaccaaaa      420

catacatgaa tgggaagcct ctctttgaat cttccatttg tggtgacagt gctgctgatg      480

tgtctcagtc agaagaaaat ggacaaaaac cagaaaacaa ggcgagaagg aacaggaaga      540

ggagcataaa atatgactcc ttgctggagc agggccttgt cgaagcagct cttgtgtcta      600

agatctcaag tccttcagat aaaaagattc cagctaagaa agagtcttgt ccaaacactg      660

gaagagacaa agaccacctg ttgaaataca acgttggtga tttggtgtgg tccaaagtgt      720

cgggttaccc ttggtggcct tgcatggttt ctgcagatcc actccttcac agctatacca      780

aacttaaagg tcagaaaaag agtgcacgcc agtatcacgt acagttcttt ggtgacgccc      840

cagaaagagc ttggatattt gagaagagcc tcgtagcttt tgaaggagaa ggacagtttg      900

aaaaattatg ccaggaaagt gccaagcagg cacccacgaa agctgagaaa attaagctat      960

tgaaaccaat ttcagggaaa ttgagggccc agtgggaaat gggcattgtt caagcagaag     1020

aagctgcaag catgtcagtg gaggagcgga aagccaagtt cacctttctc tatgtggggg     1080

accagcttca tctcaaccct caagtagcca aggaggctgg cattgctgca gagtctttgg     1140

gagaaatggc agaatcctca ggagtcagtg aagaagctgc tgaaaacccc aagtctgtga     1200

gagaagagtg cattcccatg aagagaaggc ggagggccaa actgtgtagc tctgcagaga     1260

ccctggagag tcaccccgac atagggaaga gtactcctca aaagacggca gaggctgacc     1320

ccagaagagg agtagggtct cctcctggga ggaagaagac cacagtctcc atgccacgaa     1380

gcaggaaggg agatgcagca tcccagtttt tggtcttctg tcaaaaacac agggatgagg     1440

tggtagctga gcacccagat gcttcaggtg aggagattga agagctgctc aggtcacagt     1500

ggagtctgct gagtgagaag cagagagcac gctacaacac caagtttgcc ctggtggccc     1560

ctgtccaggc tgaagaagac tctggtaatg taaatgggaa aaaaagaaac cacacaaaga     1620

ggatacagga ccctacagaa gatgctgaag ctgaggacac acccaggaaa agactcagga     1680

cggacaagca cagtcttcgg aagagagaca caatcactga caaaacggcc agaacaagct     1740

cttacaaggc catggaggca gcctcctcgc tcaagagcca ggcagcaacg aaaaatctgt     1800

ctgatgcatg taaaccactg aagaagcgaa atcgggcttc cacggcagca tcttcagctc     1860

ttgggtttag caaaagttca tctccttctg catccttaac tgagaatgag gtctcggaca     1920

gcccgggaga cgagccctcg gagtccccat acgaaagtgc agacgaaaca caaactgaag     1980

tatctgtctc atccaaaaag tctgagcgag gagtgactgc caaaaaggag tatgtgtgcc     2040

agctgtgtga gaagccgggc agcctcctgc tctgtgaagg accctgctgc ggagctttcc     2100

acctcgcctg ccttgggctt tcccggaggc cagaagggag gttcacctgc agcgagtgtg     2160

cctcagggat tcactcatgt ttcgtgtgta aagagagcaa gacagatgtt aagcgctgtg     2220

tggtaactca gtgtggaaaa ttttaccatg aggcttgtgt gaaaaaatac cctctgactg     2280

tatttgagag ccgaggtttc cgctgccccc tccacagctg tgtgagctgc catgcttcca     2340

acccttcaaa cccaaggccg tcaaaaggta aaatgatgcg gtgtgtccgc tgccccgttg     2400

cctatcacag cggggatgct tgtctggcag caggatgctc agtgatcgcc tccaacagca     2460

tcatctgcac tgcccacttc actgctcgga aggggaagcg acaccacgcc cacgtcaacg     2520

tgagctggtg cttcgtgtgc tccaaagggg ggagccttct gtgctgtgag tcctgcccag     2580

cggccttcca ccctgactgc ctgaacatcg agatgcctga cggcagctgg ttctgcaatg     2640

actgcagggc tgggaagaag ctgcacttcc aggatatcat ttgggtgaaa cttgggaact     2700

acagatggtg gccggcagaa gtttgccatc ccaaaaatgt tcccccaaat attcagaaaa     2760

tgaagcacga gattggagaa ttccctgtgt ttttctttgg gtctaaagat tattactgga     2820

cgcatcaggc gcgagtgttc ccgtacatgg agggggaccg gggcagccgc taccaggggg     2880

tcagagggat cggaagagtc ttcaaaaacg cactgcaaga agctgaagct cgttttcgtg     2940

aaattaagct tcagagggaa gcccgagaaa cacaggagag cgagcgcaag cccccaccat     3000

acaagcacat caaggtgaat aagccttacg ggaaagtcca gatctacaca gcggatattt     3060

cagaaatccc taagtgcaac tgcaagccca cagatgagaa tccttgtggc tttgattcgg     3120

agtgtctgaa caggatgctg atgtttgagt gccacccgca ggtgtgtccc gcgggcgagt     3180

tctgccagaa ccagtgcttc accaagcgcc agtacccaga gaccaagatc atcaagacag     3240

atggcaaagg gtggggcctg gtcgccaaga gggacatcag aaagggagaa tttgttaacg     3300

agtacgttgg ggagctgatc gacgaggagg agtgcatggc gagaatcaag cacgcacacg     3360

agaacgacat cacccacttc tacatgctca ctatagacaa ggaccgtata atagacgctg     3420

gccccaaagg aaactactct cgatttatga atcacagctg ccagcccaac tgtgagaccc     3480

tcaagtggac agtgaatggg gacactcgtg tgggcctgtt tgccgtctgt gacattcctg     3540

cagggacgga gctgactttt aactacaacc tcgattgtct gggcaatgaa aaaacggtct     3600

gccggtgtgg agcctccaat tgcagtggat tcctcgggga tagaccaaag acctcgacga     3660

ccctttcatc agaggaaaag ggcaaaaaga ccaagaagaa aacgaggcgg cgcagagcaa     3720

aaggggaagg gaagaggcag tcagaggacg agtgcttccg ctgcggtgat ggcgggcagc     3780

tggtgctgtg tgaccgcaag ttctgcacca aggcctacca cctgtcctgc ctgggccttg     3840

gcaagcggcc cttcgggaag tgggaatgtc cttggcatca ttgtgacgtg tgtggcaaac     3900

cttcgacttc attttgccac ctctgcccca attcgttctg taaggagcac caggacggga     3960

cagccttcag ctgcaccccg gacgggcggt cctactgctg tgagcatgac ttaggggcgg     4020

catcggtcag aagcaccaag actgagaagc cccccccaga gccagggaag ccgaagggga     4080

agaggcggcg gcggaggggc tggcggagag tcacagaggg caaatagcgc caggcggccg     4140

cttggccgga tccaggggcg gtgcagggcg gccggccctg cctgcgggag agggcgagca     4200

tgaactggcc cggaggaccc agctcgagcc gccaggacac agacgtacag gcctcctcgg     4260

gagggagcgc ctccccacca ctgagccatc ctcagcagcg tccgctgcgt ctgcactgat     4320

gaccgtctga gcccagctca gcgttcctgg acaaacagcc tcactcctca gcgttaccgc     4380

cacacttgaa tttctccgaa tgtcaaggtt ccctcccact ctattttttt aggttaaagt     4440

taattggcat atggaatgtt ttaatctcct ctgaaatgtg tagcgtaggc ttttcccaag     4500

ggtcgctaga aactcgtctt cgcgttgccc cctttctggc tctcagcgcc gtcgccactc     4560

gggagaggct gggtgaggcc cgtgtgagga ctgaccctgg attcctcgaa actgccattg     4620

tgatcattac tctgctcttt ggaaatggct gtatcatttt tttgtactaa tgtgaattgt     4680

tcctcagaaa cgcttctttt ccatcctagt gagaagctgg ccctgcaggt ggtggcagca     4740

atggtgttgt aagatttcct cccgtagttt tttctcctca tggatttgaa tgaaatgcca     4800

ataacacgtc cactttcaac gtgtagttta cgcggagcac tttcgaggcc tggccgggtt     4860

gggcctactt ctcacctggg cctatcttct gaactcgcta ggttcttatc aacatttggg     4920

ggataacttt gtatattttt ttcatttggc ttttctttac cagtttctga tttttattct     4980

caatatattt ttgctaaacc tatttcacaa atcaccaccg actgaagtgt gtgtttactg     5040

atgcggccct gagctccatg gcgaaaggag tgactttgca gggcgtgaga ccgcagtctg     5100

cttagagcac aggaagtgac aacttaggga gccccgtagg gcgctgcagg ccccggggac     5160

cccagcacgt gggtctaaag agagacggag tctagctctc ctgccaccca gagtggcttc     5220

catctcagca ctctgtgggt ctggtgatgg aagatgcagt ctctgctgat cacatgtgcc     5280

ctctgccagg gcacctactg agaggtgcgg tcctgggggt ggaggcctgc ctggcaggtg     5340

tgcgtgcctc gtacgtgtgt tatgggcact ggtctaggcc aggtatgaca cccactctcc     5400

tgtgagattt cactttagtt tttaaaaggt ccagttctac agagtgagac ctatctatct     5460

gagtactaca tatgttttaa gacttggttc tttttttgag ggatccttga ccctgggaag     5520

tctggagcac cctgagaagg gggcaccatg tgtgcctttg cccacgtgtc ctgaggggct     5580

gcttgtctgg gagggaggga gagaacattc agcagcaggt gcttttttat ggccttttct     5640

taaaataacc taagggggac acatccatct tgcagagaag tttacagaac tccccttgaa     5700

aactgctgct gaggctcctg ttaaattttc tgtggcatct tttatgcctt ggtaaaaact     5760

gcagtgtctt tggacctgag agtggctact ccgtggtttt gtgacctgta agcgtggggt     5820

tcaggggtgt gtggccctgc agggtcccac gcctccctga gcactgactg gaagtttcac     5880

tggctggtgg ctgtcccttc tcccatcagg gtccccagca aagttaacta cacagaggac     5940

ccaggggaaa cgagctgtgt agccactgac ttgctcgcgc ggccgtggcc tctgaggggc     6000

actcgccggt taagacaggg tgggagtagt gctttccagt tcagactcta acttctccca     6060

aagtgtccta agaaaatact ggatcggctc atagatttat gctccttatg atgccctaac     6120

ttggaaggtt gttctaggga caggccgggc agtgtcccca cacacacctt agagtcgaag     6180

gccccagggc cccgctgtca cttgcccaaa agatcccttc cggcaggtaa gggactacca     6240

atgcttacgt caaaacagca gaatcggctt tgcagtgcac tttggggagc agatattaac     6300

ttatttttgt gttggacagt agtgaaatct tgtgattttt aatcgctttg ataatacttc     6360

caaattttat gatttttctg aaggaaataa tgcaaacatt ttaaatatgt ttctccccct     6420

ttccaaaaac tgttaaacta atgagcaagt aacactaact ttgaatgtct ctacaatacc     6480

cgttgataac tcagtggagc caggctttgg ggtagcggcc ctgagcttgc agggtttctc     6540

gccactgggg ctgaccacgc ccccagctgt gaccgtgggt gtggctggct ctcggccctg     6600

cccagctttg ttctgaggac gtggtgactt cctgaacatc agcttcaatc ctccatcatt     6660

aatgtgaagc aaaacacaaa aaccgcccca atccctcagg attccttggc atccgaaacc     6720

agcatctgca cctaaaccca tacccacccg tgtgcgccca cagggggatg tgtccgaatg     6780

ggcagcttaa aatgtggtca cctgtggggg aaactcttca ggcacctgaa gtgagaaccc     6840

agctgtccgt cctcaggccg gcctttcttc cggcgacacc cgtccatggc tggctgggtc     6900

cccttcgcag tgtttgtctg tcttgacatc taaaccccgg cgtgtgcagt gcccatcttc     6960

caggactacc ttattttcca gaattaaacc tgttttataa ttcaagttaa tgcaaatgac     7020

tgtcagttgc caaatatctt gatcctgtga gtgtagttga tgactgtttg ttagtcagta     7080

gagtaaaatg ctgtgtccac ggggtgtcac agcctcacca taccctgttg aggtgtgaaa     7140

tgccccgtca gaaattaaat acaaacttaa atgtgcctat tggtgtctaa acttcataca     7200

atgtaaggtc agattccttt taggaatact gggtgctgtc accaggtttg atagttagac     7260

ttaaaaactt gaaattcact ttttgggggg agggatatac tgaaatagag agttgagact     7320

tgccagttgg gggaaaatag catttaaaat ggaaagctgt gtttggaaaa ttgtgtatga     7380

gtatttttgt attaaaaaca ttttaaaggc ttttttct                             7418


<210>  2
<211>  1365
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Phe Ser Ile Lys Gln Ser Pro Leu Ser Val Gln Ser Val Val 
1               5                   10                  15      


Lys Cys Ile Lys Met Lys Gln Ala Pro Glu Ile Leu Gly Ser Ala Asn 
            20                  25                  30          


Gly Lys Thr Pro Ser Cys Glu Val Asn Arg Glu Cys Ser Val Phe Leu 
        35                  40                  45              


Ser Lys Ala Gln Leu Ser Ser Ser Leu Gln Glu Gly Val Met Gln Lys 
    50                  55                  60                  


Phe Asn Gly His Asp Ala Leu Pro Phe Ile Pro Ala Asp Lys Leu Lys 
65                  70                  75                  80  


Asp Leu Thr Ser Arg Val Phe Asn Gly Glu Pro Gly Ala His Asp Ala 
                85                  90                  95      


Lys Leu Arg Phe Glu Ser Gln Glu Met Lys Gly Ile Gly Thr Pro Pro 
            100                 105                 110         


Asn Thr Thr Pro Ile Lys Asn Gly Ser Pro Glu Ile Lys Leu Lys Ile 
        115                 120                 125             


Thr Lys Thr Tyr Met Asn Gly Lys Pro Leu Phe Glu Ser Ser Ile Cys 
    130                 135                 140                 


Gly Asp Ser Ala Ala Asp Val Ser Gln Ser Glu Glu Asn Gly Gln Lys 
145                 150                 155                 160 


Pro Glu Asn Lys Ala Arg Arg Asn Arg Lys Arg Ser Ile Lys Tyr Asp 
                165                 170                 175     


Ser Leu Leu Glu Gln Gly Leu Val Glu Ala Ala Leu Val Ser Lys Ile 
            180                 185                 190         


Ser Ser Pro Ser Asp Lys Lys Ile Pro Ala Lys Lys Glu Ser Cys Pro 
        195                 200                 205             


Asn Thr Gly Arg Asp Lys Asp His Leu Leu Lys Tyr Asn Val Gly Asp 
    210                 215                 220                 


Leu Val Trp Ser Lys Val Ser Gly Tyr Pro Trp Trp Pro Cys Met Val 
225                 230                 235                 240 


Ser Ala Asp Pro Leu Leu His Ser Tyr Thr Lys Leu Lys Gly Gln Lys 
                245                 250                 255     


Lys Ser Ala Arg Gln Tyr His Val Gln Phe Phe Gly Asp Ala Pro Glu 
            260                 265                 270         


Arg Ala Trp Ile Phe Glu Lys Ser Leu Val Ala Phe Glu Gly Glu Gly 
        275                 280                 285             


Gln Phe Glu Lys Leu Cys Gln Glu Ser Ala Lys Gln Ala Pro Thr Lys 
    290                 295                 300                 


Ala Glu Lys Ile Lys Leu Leu Lys Pro Ile Ser Gly Lys Leu Arg Ala 
305                 310                 315                 320 


Gln Trp Glu Met Gly Ile Val Gln Ala Glu Glu Ala Ala Ser Met Ser 
                325                 330                 335     


Val Glu Glu Arg Lys Ala Lys Phe Thr Phe Leu Tyr Val Gly Asp Gln 
            340                 345                 350         


Leu His Leu Asn Pro Gln Val Ala Lys Glu Ala Gly Ile Ala Ala Glu 
        355                 360                 365             


Ser Leu Gly Glu Met Ala Glu Ser Ser Gly Val Ser Glu Glu Ala Ala 
    370                 375                 380                 


Glu Asn Pro Lys Ser Val Arg Glu Glu Cys Ile Pro Met Lys Arg Arg 
385                 390                 395                 400 


Arg Arg Ala Lys Leu Cys Ser Ser Ala Glu Thr Leu Glu Ser His Pro 
                405                 410                 415     


Asp Ile Gly Lys Ser Thr Pro Gln Lys Thr Ala Glu Ala Asp Pro Arg 
            420                 425                 430         


Arg Gly Val Gly Ser Pro Pro Gly Arg Lys Lys Thr Thr Val Ser Met 
        435                 440                 445             


Pro Arg Ser Arg Lys Gly Asp Ala Ala Ser Gln Phe Leu Val Phe Cys 
    450                 455                 460                 


Gln Lys His Arg Asp Glu Val Val Ala Glu His Pro Asp Ala Ser Gly 
465                 470                 475                 480 


Glu Glu Ile Glu Glu Leu Leu Arg Ser Gln Trp Ser Leu Leu Ser Glu 
                485                 490                 495     


Lys Gln Arg Ala Arg Tyr Asn Thr Lys Phe Ala Leu Val Ala Pro Val 
            500                 505                 510         


Gln Ala Glu Glu Asp Ser Gly Asn Val Asn Gly Lys Lys Arg Asn His 
        515                 520                 525             


Thr Lys Arg Ile Gln Asp Pro Thr Glu Asp Ala Glu Ala Glu Asp Thr 
    530                 535                 540                 


Pro Arg Lys Arg Leu Arg Thr Asp Lys His Ser Leu Arg Lys Arg Asp 
545                 550                 555                 560 


Thr Ile Thr Asp Lys Thr Ala Arg Thr Ser Ser Tyr Lys Ala Met Glu 
                565                 570                 575     


Ala Ala Ser Ser Leu Lys Ser Gln Ala Ala Thr Lys Asn Leu Ser Asp 
            580                 585                 590         


Ala Cys Lys Pro Leu Lys Lys Arg Asn Arg Ala Ser Thr Ala Ala Ser 
        595                 600                 605             


Ser Ala Leu Gly Phe Ser Lys Ser Ser Ser Pro Ser Ala Ser Leu Thr 
    610                 615                 620                 


Glu Asn Glu Val Ser Asp Ser Pro Gly Asp Glu Pro Ser Glu Ser Pro 
625                 630                 635                 640 


Tyr Glu Ser Ala Asp Glu Thr Gln Thr Glu Val Ser Val Ser Ser Lys 
                645                 650                 655     


Lys Ser Glu Arg Gly Val Thr Ala Lys Lys Glu Tyr Val Cys Gln Leu 
            660                 665                 670         


Cys Glu Lys Pro Gly Ser Leu Leu Leu Cys Glu Gly Pro Cys Cys Gly 
        675                 680                 685             


Ala Phe His Leu Ala Cys Leu Gly Leu Ser Arg Arg Pro Glu Gly Arg 
    690                 695                 700                 


Phe Thr Cys Ser Glu Cys Ala Ser Gly Ile His Ser Cys Phe Val Cys 
705                 710                 715                 720 


Lys Glu Ser Lys Thr Asp Val Lys Arg Cys Val Val Thr Gln Cys Gly 
                725                 730                 735     


Lys Phe Tyr His Glu Ala Cys Val Lys Lys Tyr Pro Leu Thr Val Phe 
            740                 745                 750         


Glu Ser Arg Gly Phe Arg Cys Pro Leu His Ser Cys Val Ser Cys His 
        755                 760                 765             


Ala Ser Asn Pro Ser Asn Pro Arg Pro Ser Lys Gly Lys Met Met Arg 
    770                 775                 780                 


Cys Val Arg Cys Pro Val Ala Tyr His Ser Gly Asp Ala Cys Leu Ala 
785                 790                 795                 800 


Ala Gly Cys Ser Val Ile Ala Ser Asn Ser Ile Ile Cys Thr Ala His 
                805                 810                 815     


Phe Thr Ala Arg Lys Gly Lys Arg His His Ala His Val Asn Val Ser 
            820                 825                 830         


Trp Cys Phe Val Cys Ser Lys Gly Gly Ser Leu Leu Cys Cys Glu Ser 
        835                 840                 845             


Cys Pro Ala Ala Phe His Pro Asp Cys Leu Asn Ile Glu Met Pro Asp 
    850                 855                 860                 


Gly Ser Trp Phe Cys Asn Asp Cys Arg Ala Gly Lys Lys Leu His Phe 
865                 870                 875                 880 


Gln Asp Ile Ile Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala 
                885                 890                 895     


Glu Val Cys His Pro Lys Asn Val Pro Pro Asn Ile Gln Lys Met Lys 
            900                 905                 910         


His Glu Ile Gly Glu Phe Pro Val Phe Phe Phe Gly Ser Lys Asp Tyr 
        915                 920                 925             


Tyr Trp Thr His Gln Ala Arg Val Phe Pro Tyr Met Glu Gly Asp Arg 
    930                 935                 940                 


Gly Ser Arg Tyr Gln Gly Val Arg Gly Ile Gly Arg Val Phe Lys Asn 
945                 950                 955                 960 


Ala Leu Gln Glu Ala Glu Ala Arg Phe Arg Glu Ile Lys Leu Gln Arg 
                965                 970                 975     


Glu Ala Arg Glu Thr Gln Glu Ser Glu Arg Lys Pro Pro Pro Tyr Lys 
            980                 985                 990         


His Ile Lys Val Asn Lys Pro Tyr  Gly Lys Val Gln Ile  Tyr Thr Ala 
        995                 1000                 1005             


Asp Ile  Ser Glu Ile Pro Lys  Cys Asn Cys Lys Pro  Thr Asp Glu 
    1010                 1015                 1020             


Asn Pro  Cys Gly Phe Asp Ser  Glu Cys Leu Asn Arg  Met Leu Met 
    1025                 1030                 1035             


Phe Glu  Cys His Pro Gln Val  Cys Pro Ala Gly Glu  Phe Cys Gln 
    1040                 1045                 1050             


Asn Gln  Cys Phe Thr Lys Arg  Gln Tyr Pro Glu Thr  Lys Ile Ile 
    1055                 1060                 1065             


Lys Thr  Asp Gly Lys Gly Trp  Gly Leu Val Ala Lys  Arg Asp Ile 
    1070                 1075                 1080             


Arg Lys  Gly Glu Phe Val Asn  Glu Tyr Val Gly Glu  Leu Ile Asp 
    1085                 1090                 1095             


Glu Glu  Glu Cys Met Ala Arg  Ile Lys His Ala His  Glu Asn Asp 
    1100                 1105                 1110             


Ile Thr  His Phe Tyr Met Leu  Thr Ile Asp Lys Asp  Arg Ile Ile 
    1115                 1120                 1125             


Asp Ala  Gly Pro Lys Gly Asn  Tyr Ser Arg Phe Met  Asn His Ser 
    1130                 1135                 1140             


Cys Gln  Pro Asn Cys Glu Thr  Leu Lys Trp Thr Val  Asn Gly Asp 
    1145                 1150                 1155             


Thr Arg  Val Gly Leu Phe Ala  Val Cys Asp Ile Pro  Ala Gly Thr 
    1160                 1165                 1170             


Glu Leu  Thr Phe Asn Tyr Asn  Leu Asp Cys Leu Gly  Asn Glu Lys 
    1175                 1180                 1185             


Thr Val  Cys Arg Cys Gly Ala  Ser Asn Cys Ser Gly  Phe Leu Gly 
    1190                 1195                 1200             


Asp Arg  Pro Lys Thr Ser Thr  Thr Leu Ser Ser Glu  Glu Lys Gly 
    1205                 1210                 1215             


Lys Lys  Thr Lys Lys Lys Thr  Arg Arg Arg Arg Ala  Lys Gly Glu 
    1220                 1225                 1230             


Gly Lys  Arg Gln Ser Glu Asp  Glu Cys Phe Arg Cys  Gly Asp Gly 
    1235                 1240                 1245             


Gly Gln  Leu Val Leu Cys Asp  Arg Lys Phe Cys Thr  Lys Ala Tyr 
    1250                 1255                 1260             


His Leu  Ser Cys Leu Gly Leu  Gly Lys Arg Pro Phe  Gly Lys Trp 
    1265                 1270                 1275             


Glu Cys  Pro Trp His His Cys  Asp Val Cys Gly Lys  Pro Ser Thr 
    1280                 1285                 1290             


Ser Phe  Cys His Leu Cys Pro  Asn Ser Phe Cys Lys  Glu His Gln 
    1295                 1300                 1305             


Asp Gly  Thr Ala Phe Ser Cys  Thr Pro Asp Gly Arg  Ser Tyr Cys 
    1310                 1315                 1320             


Cys Glu  His Asp Leu Gly Ala  Ala Ser Val Arg Ser  Thr Lys Thr 
    1325                 1330                 1335             


Glu Lys  Pro Pro Pro Glu Pro  Gly Lys Pro Lys Gly  Lys Arg Arg 
    1340                 1345                 1350             


Arg Arg  Arg Gly Trp Arg Arg  Val Thr Glu Gly Lys  
    1355                 1360                 1365 


<210>  3
<211>  1365
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Phe Ser Ile Lys Gln Ser Pro Leu Ser Val Gln Ser Val Val 
1               5                   10                  15      


Lys Cys Ile Lys Met Lys Gln Ala Pro Glu Ile Leu Gly Ser Ala Asn 
            20                  25                  30          


Gly Lys Thr Pro Ser Cys Glu Val Asn Arg Glu Cys Ser Val Phe Leu 
        35                  40                  45              


Ser Lys Ala Gln Leu Ser Ser Ser Leu Gln Glu Gly Val Met Gln Lys 
    50                  55                  60                  


Phe Asn Gly His Asp Ala Leu Pro Phe Ile Pro Ala Asp Lys Leu Lys 
65                  70                  75                  80  


Asp Leu Thr Ser Arg Val Phe Asn Gly Glu Pro Gly Ala His Asp Ala 
                85                  90                  95      


Lys Leu Arg Phe Glu Ser Gln Glu Met Lys Gly Ile Gly Thr Pro Pro 
            100                 105                 110         


Asn Thr Thr Pro Ile Lys Asn Gly Ser Pro Glu Ile Lys Leu Lys Ile 
        115                 120                 125             


Thr Lys Thr Tyr Met Asn Gly Lys Pro Leu Phe Glu Ser Ser Ile Cys 
    130                 135                 140                 


Gly Asp Ser Ala Ala Asp Val Ser Gln Ser Glu Glu Asn Gly Gln Lys 
145                 150                 155                 160 


Pro Glu Asn Lys Ala Arg Arg Asn Arg Lys Arg Ser Ile Lys Tyr Asp 
                165                 170                 175     


Ser Leu Leu Glu Gln Gly Leu Val Glu Ala Ala Leu Val Ser Lys Ile 
            180                 185                 190         


Ser Ser Pro Ser Asp Lys Lys Ile Pro Ala Lys Lys Glu Ser Cys Pro 
        195                 200                 205             


Asn Thr Gly Arg Asp Lys Asp His Leu Leu Lys Tyr Asn Val Gly Asp 
    210                 215                 220                 


Leu Val Trp Ser Lys Val Ser Gly Tyr Pro Trp Trp Pro Cys Met Val 
225                 230                 235                 240 


Ser Ala Asp Pro Leu Leu His Ser Tyr Thr Lys Leu Lys Gly Gln Lys 
                245                 250                 255     


Lys Ser Ala Arg Gln Tyr His Val Gln Phe Phe Gly Asp Ala Pro Glu 
            260                 265                 270         


Arg Ala Trp Ile Phe Glu Lys Ser Leu Val Ala Phe Glu Gly Glu Gly 
        275                 280                 285             


Gln Phe Glu Lys Leu Cys Gln Glu Ser Ala Lys Gln Ala Pro Thr Lys 
    290                 295                 300                 


Ala Glu Lys Ile Lys Leu Leu Lys Pro Ile Ser Gly Lys Leu Arg Ala 
305                 310                 315                 320 


Gln Trp Glu Met Gly Ile Val Gln Ala Glu Glu Ala Ala Ser Met Ser 
                325                 330                 335     


Val Glu Glu Arg Lys Ala Lys Phe Thr Phe Leu Tyr Val Gly Asp Gln 
            340                 345                 350         


Leu His Leu Asn Pro Gln Val Ala Lys Glu Ala Gly Ile Ala Ala Glu 
        355                 360                 365             


Ser Leu Gly Glu Met Ala Glu Ser Ser Gly Val Ser Glu Glu Ala Ala 
    370                 375                 380                 


Glu Asn Pro Lys Ser Val Arg Glu Glu Cys Ile Pro Met Lys Arg Arg 
385                 390                 395                 400 


Arg Arg Ala Lys Leu Cys Ser Ser Ala Glu Thr Leu Glu Ser His Pro 
                405                 410                 415     


Asp Ile Gly Lys Ser Thr Pro Gln Lys Thr Ala Glu Ala Asp Pro Arg 
            420                 425                 430         


Arg Gly Val Gly Ser Pro Pro Gly Arg Lys Lys Thr Thr Val Ser Met 
        435                 440                 445             


Pro Arg Ser Arg Lys Gly Asp Ala Ala Ser Gln Phe Leu Val Phe Cys 
    450                 455                 460                 


Gln Lys His Arg Asp Glu Val Val Ala Glu His Pro Asp Ala Ser Gly 
465                 470                 475                 480 


Glu Glu Ile Glu Glu Leu Leu Arg Ser Gln Trp Ser Leu Leu Ser Glu 
                485                 490                 495     


Lys Gln Arg Ala Arg Tyr Asn Thr Lys Phe Ala Leu Val Ala Pro Val 
            500                 505                 510         


Gln Ala Glu Glu Asp Ser Gly Asn Val Asn Gly Lys Lys Arg Asn His 
        515                 520                 525             


Thr Lys Arg Ile Gln Asp Pro Thr Glu Asp Ala Glu Ala Glu Asp Thr 
    530                 535                 540                 


Pro Arg Lys Arg Leu Arg Thr Asp Lys His Ser Leu Arg Lys Arg Asp 
545                 550                 555                 560 


Thr Ile Thr Asp Lys Thr Ala Arg Thr Ser Ser Tyr Lys Ala Met Glu 
                565                 570                 575     


Ala Ala Ser Ser Leu Lys Ser Gln Ala Ala Thr Lys Asn Leu Ser Asp 
            580                 585                 590         


Ala Cys Lys Pro Leu Lys Lys Arg Asn Arg Ala Ser Thr Ala Ala Ser 
        595                 600                 605             


Ser Ala Leu Gly Phe Ser Lys Ser Ser Ser Pro Ser Ala Ser Leu Thr 
    610                 615                 620                 


Glu Asn Glu Val Ser Asp Ser Pro Gly Asp Glu Pro Ser Glu Ser Pro 
625                 630                 635                 640 


Tyr Glu Ser Ala Asp Glu Thr Gln Thr Glu Val Ser Val Ser Ser Lys 
                645                 650                 655     


Lys Ser Glu Arg Gly Val Thr Ala Lys Lys Glu Tyr Val Cys Gln Leu 
            660                 665                 670         


Cys Glu Lys Pro Gly Ser Leu Leu Leu Cys Glu Gly Pro Cys Cys Gly 
        675                 680                 685             


Ala Phe His Leu Ala Cys Leu Gly Leu Ser Arg Arg Pro Glu Gly Arg 
    690                 695                 700                 


Phe Thr Cys Ser Glu Cys Ala Ser Gly Ile His Ser Cys Phe Val Cys 
705                 710                 715                 720 


Lys Glu Ser Lys Thr Asp Val Lys Arg Cys Val Val Thr Gln Cys Gly 
                725                 730                 735     


Lys Phe Tyr His Glu Ala Cys Val Lys Lys Tyr Pro Leu Thr Val Phe 
            740                 745                 750         


Glu Ser Arg Gly Phe Arg Cys Pro Leu His Ser Cys Val Ser Cys His 
        755                 760                 765             


Ala Ser Asn Pro Ser Asn Pro Arg Pro Ser Lys Gly Lys Met Met Arg 
    770                 775                 780                 


Cys Val Arg Cys Pro Val Ala Tyr His Ser Gly Asp Ala Cys Leu Ala 
785                 790                 795                 800 


Ala Gly Cys Ser Val Ile Ala Ser Asn Ser Ile Ile Cys Thr Ala His 
                805                 810                 815     


Phe Thr Ala Arg Lys Gly Lys Arg His His Ala His Val Asn Val Ser 
            820                 825                 830         


Trp Cys Phe Val Cys Ser Lys Gly Gly Ser Leu Leu Cys Cys Glu Ser 
        835                 840                 845             


Cys Pro Ala Ala Phe His Pro Asp Cys Leu Asn Ile Glu Met Pro Asp 
    850                 855                 860                 


Gly Ser Trp Phe Cys Asn Asp Cys Arg Ala Gly Lys Lys Leu His Phe 
865                 870                 875                 880 


Gln Asp Ile Ile Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala 
                885                 890                 895     


Glu Val Cys His Pro Lys Asn Val Pro Pro Asn Ile Gln Lys Met Lys 
            900                 905                 910         


His Glu Ile Gly Glu Phe Pro Val Phe Phe Phe Gly Ser Lys Asp Tyr 
        915                 920                 925             


Tyr Trp Thr His Gln Ala Arg Val Phe Pro Tyr Met Glu Gly Asp Arg 
    930                 935                 940                 


Gly Ser Arg Tyr Gln Gly Val Arg Gly Ile Gly Arg Val Phe Lys Asn 
945                 950                 955                 960 


Ala Leu Gln Glu Ala Glu Ala Arg Phe Arg Glu Ile Lys Leu Gln Arg 
                965                 970                 975     


Glu Ala Arg Glu Thr Gln Glu Ser Glu Arg Lys Pro Pro Pro Tyr Lys 
            980                 985                 990         


His Ile Lys Val Asn Lys Pro Tyr  Gly Lys Val Gln Ile  Tyr Thr Ala 
        995                 1000                 1005             


Asp Ile  Ser Glu Ile Pro Lys  Cys Asn Cys Lys Pro  Thr Asp Glu 
    1010                 1015                 1020             


Asn Pro  Cys Gly Phe Asp Ser  Glu Cys Leu Asn Arg  Met Leu Met 
    1025                 1030                 1035             


Phe Glu  Cys His Pro Gln Val  Cys Pro Ala Gly Glu  Phe Cys Gln 
    1040                 1045                 1050             


Asn Gln  Cys Phe Thr Lys Arg  Gln Tyr Pro Glu Thr  Lys Ile Ile 
    1055                 1060                 1065             


Lys Thr  Asp Gly Lys Gly Trp  Gly Leu Val Ala Lys  Arg Asp Ile 
    1070                 1075                 1080             


Arg Lys  Gly Glu Phe Val Asn  Glu Tyr Val Gly Glu  Leu Ile Asp 
    1085                 1090                 1095             


Lys Glu  Glu Cys Met Ala Arg  Ile Lys His Ala His  Glu Asn Asp 
    1100                 1105                 1110             


Ile Thr  His Phe Tyr Met Leu  Thr Ile Asp Lys Asp  Arg Ile Ile 
    1115                 1120                 1125             


Asp Ala  Gly Pro Lys Gly Asn  Tyr Ser Arg Phe Met  Asn His Ser 
    1130                 1135                 1140             


Cys Gln  Pro Asn Cys Glu Thr  Leu Lys Trp Thr Val  Asn Gly Asp 
    1145                 1150                 1155             


Thr Arg  Val Gly Leu Phe Ala  Val Cys Asp Ile Pro  Ala Gly Thr 
    1160                 1165                 1170             


Glu Leu  Thr Phe Asn Tyr Asn  Leu Asp Cys Leu Gly  Asn Glu Lys 
    1175                 1180                 1185             


Thr Val  Cys Arg Cys Gly Ala  Ser Asn Cys Ser Gly  Phe Leu Gly 
    1190                 1195                 1200             


Asp Arg  Pro Lys Thr Ser Thr  Thr Leu Ser Ser Glu  Glu Lys Gly 
    1205                 1210                 1215             


Lys Lys  Thr Lys Lys Lys Thr  Arg Arg Arg Arg Ala  Lys Gly Glu 
    1220                 1225                 1230             


Gly Lys  Arg Gln Ser Glu Asp  Glu Cys Phe Arg Cys  Gly Asp Gly 
    1235                 1240                 1245             


Gly Gln  Leu Val Leu Cys Asp  Arg Lys Phe Cys Thr  Lys Ala Tyr 
    1250                 1255                 1260             


His Leu  Ser Cys Leu Gly Leu  Gly Lys Arg Pro Phe  Gly Lys Trp 
    1265                 1270                 1275             


Glu Cys  Pro Trp His His Cys  Asp Val Cys Gly Lys  Pro Ser Thr 
    1280                 1285                 1290             


Ser Phe  Cys His Leu Cys Pro  Asn Ser Phe Cys Lys  Glu His Gln 
    1295                 1300                 1305             


Asp Gly  Thr Ala Phe Ser Cys  Thr Pro Asp Gly Arg  Ser Tyr Cys 
    1310                 1315                 1320             


Cys Glu  His Asp Leu Gly Ala  Ala Ser Val Arg Ser  Thr Lys Thr 
    1325                 1330                 1335             


Glu Lys  Pro Pro Pro Glu Pro  Gly Lys Pro Lys Gly  Lys Arg Arg 
    1340                 1345                 1350             


Arg Arg  Arg Gly Trp Arg Arg  Val Thr Glu Gly Lys  
    1355                 1360                 1365 


<210>  4
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Lys Lys Glu Tyr Val Cys Gln Leu Cys Glu Lys Thr Gly 
1               5                   10                  15      


Ser Leu Leu Leu Cys Glu Gly Pro Cys Cys Gly Ala Phe His Leu Ala 
            20                  25                  30          


Cys Leu Gly Leu Ser Arg Arg Pro Glu Gly Arg Phe Thr Cys Thr Glu 
        35                  40                  45              


Cys Ala Ser Gly Ile His Ser Cys Phe Val Cys Lys Glu Ser Lys Met 
    50                  55                  60                  


Glu Val Lys Arg Cys Val Val Asn Gln Cys Gly Lys Phe Tyr His Glu 
65                  70                  75                  80  


Ala Cys Val Lys Lys Tyr Pro Leu Thr Val Phe Glu Ser Arg Gly Phe 
                85                  90                  95      


Arg Cys Pro Leu His Ser Cys Met Ser Cys His Ala Ser Asn Pro Ser 
            100                 105                 110         


Asn Pro Arg Pro Ser Lys Gly Lys Met Met Arg Cys Val Arg Cys Pro 
        115                 120                 125             


Val Ala Tyr His Gly Gly Asp Ala Cys Leu Ala Ala Gly Cys Ser Val 
    130                 135                 140                 


Ile Ala Ser Asn Ser Ile Ile Cys Thr Gly His Phe Thr Ala Arg Lys 
145                 150                 155                 160 


Gly Lys Arg His His Thr His Val Asn Val Ser Trp Cys Phe Val Cys 
                165                 170                 175     


Ser Lys Gly Gly Ser Leu Leu Cys Cys Glu Ala Cys Pro Ala Ala Phe 
            180                 185                 190         


His Pro Asp Cys Leu Asn Ile Glu Met Pro Asp Gly Ser Trp Phe Cys 
        195                 200                 205             


Asn Asp Cys Arg Ala Gly Lys Lys Leu His Phe Gln Asp Ile Ile Trp 
    210                 215                 220                 


Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala Glu Val Cys His Pro 
225                 230                 235                 240 


Lys Asn Val Pro Pro Asn Ile Gln Lys Met Lys His Glu Ile Gly Glu 
                245                 250                 255     


Phe Pro Val Phe Phe Phe Gly Ser Lys Asp Tyr Tyr Trp Thr His Gln 
            260                 265                 270         


Ala Arg Val Phe Pro Tyr Met Glu Gly Asp Arg Gly Ser Arg Tyr Gln 
        275                 280                 285             


Gly Val Arg Gly Ile Gly Arg Val Phe Lys Asn Ala Leu Gln Glu Ala 
    290                 295                 300                 


Glu Ala Arg Phe Asn Glu Val Lys Leu Gln Arg Glu Ala Arg Glu Thr 
305                 310                 315                 320 


Gln Glu Ser Glu Arg Lys Pro Pro Pro Tyr Lys His Ile Lys Val Asn 
                325                 330                 335     


Lys Pro Tyr Gly Lys Val Gln Ile Tyr Thr Ala Asp Ile Ser Glu Ile 
            340                 345                 350         


Pro Lys Cys Asn Cys Thr Pro Thr Asp Glu Asn Pro Cys Gly Ser Asp 
        355                 360                 365             


Ser Glu Cys Leu Asn Arg Met Leu Met Phe Glu Cys His Pro Gln Val 
    370                 375                 380                 


Cys Pro Ala Gly Glu Tyr Cys Gln Asn Gln Cys Phe Thr Lys Arg Gln 
385                 390                 395                 400 


Tyr Pro Glu Thr Lys Ile Ile Lys Thr Asp Gly Lys Gly Trp Gly Leu 
                405                 410                 415     


Val Ala Lys Arg Asp Ile Arg Lys Gly Glu Phe Val Asn Glu Tyr Val 
            420                 425                 430         


Gly Glu Leu Ile Asp Glu Glu Glu Cys Met Ala Arg Ile Lys Tyr Ala 
        435                 440                 445             


His Glu Asn Asp Ile Thr His Phe Tyr Met Leu Thr Ile Asp Lys Asp 
    450                 455                 460                 


Arg Ile Ile Asp Ala Gly Pro Lys Gly Asn Tyr Ser Arg Phe Met Asn 
465                 470                 475                 480 


His Ser Cys Gln Pro Asn Cys Glu Thr Leu Lys Trp Thr Val Asn Gly 
                485                 490                 495     


Asp Thr Arg Val Gly Leu Phe Ala Val Cys Asp Ile Pro Ala Gly Thr 
            500                 505                 510         


Glu Leu Thr Phe Asn Tyr Asn Leu Asp Cys Leu Gly Asn Glu Lys Thr 
        515                 520                 525             


Val Cys Arg Cys Gly Ala Ser Asn Cys Ser Gly Phe Leu Gly Asp Arg 
    530                 535                 540                 


Pro Lys Thr Ser Ala Ser Leu Ser Ser Glu Glu Lys Gly Lys Lys Ala 
545                 550                 555                 560 


Lys Lys Lys Thr Arg Arg Arg Arg Ala Lys Gly Glu Gly Lys Arg Gln 
                565                 570                 575     


Ser Glu Asp Glu Cys Phe Arg Cys Gly Asp Gly Gly Gln Leu Val Leu 
            580                 585                 590         


Cys Asp Arg Lys Phe Cys Thr Lys Ala Tyr His Leu Ser Cys Leu Gly 
        595                 600                 605             


Leu Gly Lys Arg Pro Phe Gly Lys Trp Glu Cys Pro Trp His His Cys 
    610                 615                 620                 


Asp Val Cys Gly Lys Pro Ser Thr Ser Phe Cys His Leu Cys Pro Asn 
625                 630                 635                 640 


Ser Phe Cys Lys Glu His Gln Asp Gly Thr Ala Phe Arg Ser Thr Gln 
                645                 650                 655     


Asp Gly Gln Ser Tyr Cys Cys Glu His Asp Leu Arg Ala Asp Ser Ser 
            660                 665                 670         


Ser Ser Thr Lys Thr Glu Lys Pro Phe Pro Glu Ser Leu Lys Ser Lys 
        675                 680                 685             


Gly Lys Arg Lys Lys Arg Arg Cys Trp Arg Arg Val Thr Asp Gly Lys 
    690                 695                 700                 


<210>  5
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Phe Ser Ile Lys Gln Ser Pro Leu Ser Val Gln Ser Val Val 
1               5                   10                  15      


Lys Cys Ile Lys Met Lys Gln Ala Pro Glu Ile Leu Gly Ser Ala Asn 
            20                  25                  30          


Gly Lys Thr Pro Ser Cys Glu Val Asn Arg Glu Cys Ser Val Phe Leu 
        35                  40                  45              


Ser Lys Ala Gln Leu Ser Ser Ser Leu Gln Glu Gly Val Met Gln Lys 
    50                  55                  60                  


Phe Asn Gly His Asp Ala Leu Pro Phe Ile Pro Ala Asp Lys Leu Lys 
65                  70                  75                  80  


Asp Leu Thr Ser Arg Val Phe Asn Gly Glu Pro Gly Ala His Asp Ala 
                85                  90                  95      


Lys Leu Arg Phe Glu Ser Gln Glu Met Lys Gly Ile Gly Thr Pro Pro 
            100                 105                 110         


Asn Thr Thr Pro Ile Lys Asn Gly Ser Pro Glu Ile Lys Leu Lys Ile 
        115                 120                 125             


Thr Lys Thr Tyr Met Asn Gly Lys Pro Leu Phe Glu Ser Ser Ile Cys 
    130                 135                 140                 


Gly Asp Ser Ala Ala Asp Val Ser Gln Ser Glu Glu Asn Gly Gln Lys 
145                 150                 155                 160 


Pro Glu Asn Lys Ala Arg Arg Asn Arg Lys Arg Ser Ile Lys Tyr Asp 
                165                 170                 175     


Ser Leu Leu Glu Gln Gly Leu Val Glu Ala Ala Leu Val Ser Lys Ile 
            180                 185                 190         


Ser Ser Pro Ser Asp Lys Lys Ile Pro Ala Lys Lys Glu Ser Cys Pro 
        195                 200                 205             


Asn Thr Gly Arg Asp Lys Asp His Leu Leu Lys Tyr Asn Val Gly Asp 
    210                 215                 220                 


Leu Val Trp Ser Lys Val Ser Gly Tyr Pro Trp Trp Pro Cys Met Val 
225                 230                 235                 240 


Ser Ala Asp Pro Leu Leu His Ser Tyr Thr Lys Leu Lys Gly Gln Lys 
                245                 250                 255     


Lys Ser Ala Arg Gln Tyr His Val Gln Phe Phe Gly Asp Ala Pro Glu 
            260                 265                 270         


Arg Ala Trp Ile Phe Glu Lys Ser Leu Val Ala Phe Glu Gly Glu Gly 
        275                 280                 285             


Gln Phe Glu Lys Leu Cys Gln Glu Ser Ala Lys Gln Ala Pro Thr Lys 
    290                 295                 300                 


Ala Glu Lys Ile Lys Leu Leu Lys Pro Ile Ser Gly Lys Leu Arg Ala 
305                 310                 315                 320 


Gln Trp Glu Met Gly Ile Val Gln Ala Glu Glu Ala Ala Ser Met Ser 
                325                 330                 335     


Val Glu Glu Arg Lys Ala Lys Phe Thr Phe Leu Tyr Val Gly Asp Gln 
            340                 345                 350         


Leu His Leu Asn Pro Gln Val Ala Lys Glu Ala Gly Ile Ala Ala Glu 
        355                 360                 365             


Ser Leu Gly Glu Met Ala Glu Ser Ser Gly Val Ser Glu Glu Ala Ala 
    370                 375                 380                 


Glu Asn Pro Lys Ser Val Arg Glu Glu Cys Ile Pro Met Lys Arg Arg 
385                 390                 395                 400 


Arg Arg Ala Lys Leu Cys Ser Ser Ala Glu Thr Leu Glu Ser His Pro 
                405                 410                 415     


Asp Ile Gly Lys Ser Thr Pro Gln Lys Thr Ala Glu Ala Asp Pro Arg 
            420                 425                 430         


Arg Gly Val Gly Ser Pro Pro Gly Arg Lys Lys Thr Thr Val Ser Met 
        435                 440                 445             


Pro Arg Ser Arg Lys Gly Asp Ala Ala Ser Gln Phe Leu Val Phe Cys 
    450                 455                 460                 


Gln Lys His Arg Asp Glu Val Val Ala Glu His Pro Asp Ala Ser Gly 
465                 470                 475                 480 


Glu Glu Ile Glu Glu Leu Leu Arg Ser Gln Trp Ser Leu Leu Ser Glu 
                485                 490                 495     


Lys Gln Arg Ala Arg Tyr Asn Thr Lys Phe Ala Leu Val Ala Pro Val 
            500                 505                 510         


Gln Ala Glu Glu Asp Ser Gly Asn Val Asn Gly Lys Lys Arg Asn His 
        515                 520                 525             


Thr Lys Arg Ile Gln Asp Pro Thr Glu Asp Ala Glu Ala Glu Asp Thr 
    530                 535                 540                 


Pro Arg Lys Arg Leu Arg Thr Asp Lys His Ser Leu Arg Lys Arg Asp 
545                 550                 555                 560 


Thr Ile Thr Asp Lys Thr Ala Arg Thr Ser Ser Tyr Lys Ala Met Glu 
                565                 570                 575     


Ala Ala Ser Ser Leu Lys Ser Gln Ala Ala Thr Lys Asn Leu Ser Asp 
            580                 585                 590         


Ala Cys Lys Pro Leu Lys Lys Arg Asn Arg Ala Ser Thr Ala Ala Ser 
        595                 600                 605             


Ser Ala Leu Gly Phe Ser Lys Ser Ser Ser Pro Ser Ala Ser Leu Thr 
    610                 615                 620                 


Glu Asn Glu Leu Leu Trp Glu Pro Thr Pro Val Lys Leu Asp Leu Asn 
625                 630                 635                 640 


Pro Ala Ala Leu Tyr Cys Thr 
                645         


<210>  6
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  6
gtctgagatc ctttgaattt aatttatgga                                        30


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  7
gcgctgccac agggcaaagt ccagttctac                                        30


<210>  8
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  8
acatgctcac tatagacaa                                                    19


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  9
cggaaagcca agttcacctt t                                                 21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  10
gaataagcct tacgggaaa                                                    19


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  11
gctataactc acataatgt                                                    19


<210>  12
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  12
aagctttt                                                              8


<210>  13
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Gly Lys Gly Trp Gly Leu Val Ala Lys Arg Asp Ile Arg Lys Gly 
1               5                   10                  15      


Glu Phe Val Asn Glu Tyr Val Gly Glu Leu Ile Asp Glu Glu Glu Cys 
            20                  25                  30          


Met Ala Arg Ile Lys 
        35          


<210>  14
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
1               5                   10                  15      


Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
            20                  25                  30          


Asp Arg Arg Gly Lys 
        35          


