                         SEQUENCE LISTING

<110>  Regado Biosciences Inc.
       Novamedica
 
<120>  Nucleic Acid Modulators of Alpha2Beta1

<130>  10815.8015.WO

<150>  61/717,944
<151>  2012-10-24

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  7878
<212>  DNA
<213>  Homo sapiens

<400>  1
ttttccctgc tctcaccggg cgggggagag aagccctctg gacagcttct agagtgtgca       60

ggttctcgta tccctcggcc aagggtatcc tctgcaaacc tctgcaaacc cagcgcaact      120

acggtccccc ggtcagaccc aggatggggc cagaacggac aggggccgcg ccgctgccgc      180

tgctgctggt gttagcgctc agtcaaggca ttttaaattg ttgtttggcc tacaatgttg      240

gtctcccaga agcaaaaata ttttccggtc cttcaagtga acagtttggc tatgcagtgc      300

agcagtttat aaatccaaaa ggcaactggt tactggttgg ttcaccctgg agtggctttc      360

ctgagaaccg aatgggagat gtgtataaat gtcctgttga cctatccact gccacatgtg      420

aaaaactaaa tttgcaaact tcaacaagca ttccaaatgt tactgagatg aaaaccaaca      480

tgagcctcgg cttgatcctc accaggaaca tgggaactgg aggttttctc acatgtggtc      540

ctctgtgggc acagcaatgt gggaatcagt attacacaac gggtgtgtgt tctgacatca      600

gtcctgattt tcagctctca gccagcttct cacctgcaac tcagccctgc ccttccctca      660

tagatgttgt ggttgtgtgt gatgaatcaa atagtattta tccttgggat gcagtaaaga      720

attttttgga aaaatttgta caaggcctgg atataggccc cacaaagaca caggtggggt      780

taattcagta tgccaataat ccaagagttg tgtttaactt gaacacatat aaaaccaaag      840

aagaaatgat tgtagcaaca tcccagacat cccaatatgg tggggacctc acaaacacat      900

tcggagcaat tcaatatgca agaaaatatg cttattcagc agcttctggt gggcgacgaa      960

gtgctacgaa agtaatggta gttgtaactg acggtgaatc acatgatggt tcaatgttga     1020

aagctgtgat tgatcaatgc aaccatgaca atatactgag gtttggcata gcagttcttg     1080

ggtacttaaa cagaaacgcc cttgatacta aaaatttaat aaaagaaata aaagcaatcg     1140

ctagtattcc aacagaaaga tactttttca atgtgtctga tgaagcagct ctactagaaa     1200

aggctgggac attaggagaa caaattttca gcattgaagg tactgttcaa ggaggagaca     1260

actttcagat ggaaatgtca caagtgggat tcagtgcaga ttactcttct caaaatgata     1320

ttctgatgct gggtgcagtg ggagcttttg gctggagtgg gaccattgtc cagaagacat     1380

ctcatggcca tttgatcttt cctaaacaag cctttgacca aattctgcag gacagaaatc     1440

acagttcata tttaggttac tctgtggctg caatttctac tggagaaagc actcactttg     1500

ttgctggtgc tcctcgggca aattataccg gccagatagt gctatatagt gtgaatgaga     1560

atggcaatat cacggttatt caggctcacc gaggtgacca gattggctcc tattttggta     1620

gtgtgctgtg ttcagttgat gtggataaag acaccattac agacgtgctc ttggtaggtg     1680

caccaatgta catgagtgac ctaaagaaag aggaaggaag agtctacctg tttactatca     1740

aagagggcat tttgggtcag caccaatttc ttgaaggccc cgagggcatt gaaaacactc     1800

gatttggttc agcaattgca gctctttcag acatcaacat ggatggcttt aatgatgtga     1860

ttgttggttc accactagaa aatcagaatt ctggagctgt atacatttac aatggtcatc     1920

agggcactat ccgcacaaag tattcccaga aaatcttggg atccgatgga gcctttagga     1980

gccatctcca gtactttggg aggtccttgg atggctatgg agatttaaat ggggattcca     2040

tcaccgatgt gtctattggt gcctttggac aagtggttca actctggtca caaagtattg     2100

ctgatgtagc tatagaagct tcattcacac cagaaaaaat cactttggtc aacaagaatg     2160

ctcagataat tctcaaactc tgcttcagtg caaagttcag acctactaag caaaacaatc     2220

aagtggccat tgtatataac atcacacttg atgcagatgg attttcatcc agagtaacct     2280

ccagggggtt atttaaagaa aacaatgaaa ggtgcctgca gaagaatatg gtagtaaatc     2340

aagcacagag ttgccccgag cacatcattt atatacagga gccctctgat gttgtcaact     2400

ctttggattt gcgtgtggac atcagtctgg aaaaccctgg cactagccct gcccttgaag     2460

cctattctga gactgccaag gtcttcagta ttcctttcca caaagactgt ggtgaggacg     2520

gactttgcat ttctgatcta gtcctagatg tccgacaaat accagctgct caagaacaac     2580

cctttattgt cagcaaccaa aacaaaaggt taacattttc agtaacgctg aaaaataaaa     2640

gggaaagtgc atacaacact ggaattgttg ttgatttttc agaaaacttg ttttttgcat     2700

cattctccct gccggttgat gggacagaag taacatgcca ggtggctgca tctcagaagt     2760

ctgttgcctg cgatgtaggc taccctgctt taaagagaga acaacaggtg acttttacta     2820

ttaactttga cttcaatctt caaaaccttc agaatcaggc gtctctcagt ttccaagcct     2880

taagtgaaag ccaagaagaa aacaaggctg ataatttggt caacctcaaa attcctctcc     2940

tgtatgatgc tgaaattcac ttaacaagat ctaccaacat aaatttttat gaaatctctt     3000

cggatgggaa tgttccttca atcgtgcaca gttttgaaga tgttggtcca aaattcatct     3060

tctccctgaa ggtaacaaca ggaagtgttc cagtaagcat ggcaactgta atcatccaca     3120

tccctcagta taccaaagaa aagaacccac tgatgtacct aactggggtg caaacagaca     3180

aggctggtga catcagttgt aatgcagata tcaatccact gaaaatagga caaacatctt     3240

cttctgtatc tttcaaaagt gaaaatttca ggcacaccaa agaattgaac tgcagaactg     3300

cttcctgtag taatgttacc tgctggttga aagacgttca catgaaagga gaatactttg     3360

ttaatgtgac taccagaatt tggaacggga ctttcgcatc atcaacgttc cagacagtac     3420

agctaacggc agctgcagaa atcaacacct ataaccctga gatatatgtg attgaagata     3480

acactgttac gattcccctg atgataatga aacctgatga gaaagccgaa gtaccaacag     3540

gagttataat aggaagtata attgctggaa tccttttgct gttagctctg gttgcaattt     3600

tatggaagct cggcttcttc aaaagaaaat atgaaaagat gaccaaaaat ccagatgaga     3660

ttgatgagac cacagagctc agtagctgaa ccagcagacc tacctgcagt gggaaccggc     3720

agcatcccag ccagggtttg ctgtttgcgt gaatggattt ctttttaaat cccatatttt     3780

ttttatcatg tcgtaggtaa actaacctgg tattttaaga gaaaactgca ggtcagtttg     3840

gaatgaagaa attgtggggg gtgggggagg tgcggggggc aggtagggaa ataataggga     3900

aaatacctat tttatatgat gggggaaaaa aagtaatctt taaactggct ggcccagagt     3960

ttacattcta atttgcattg tgtcagaaac atgaaatgct tccaagcatg acaactttta     4020

aagaaaaata tgatactctc agattttaag ggggaaaact gttctcttta aaatatttgt     4080

ctttaaacag caactacaga agtggaagtg cttgatatgt aagtacttcc acttgtgtat     4140

attttaatga atattgatgt taacaagagg ggaaaacaaa acacaggttt tttcaattta     4200

tgctgctcat ccaaagttgc cacagatgat acttccaagt gataatttta tttataaact     4260

aggtaaaatt tgttgttggt tccttttaga ccacggctgc cccttccaca ccccatcttg     4320

ctctaatgat caaaacatgc ttgaataact gagcttagag tatacctcct atatgtccat     4380

ttaagttagg agagggggcg atatagagaa taaggcacaa aattttgttt aaaactcaga     4440

atataacatg taaaatccca tctgctagaa gcccatcctg tgccagagga aggaaaagga     4500

ggaaatttcc tttctctttt aggaggcaca acagttctct tctaggattt gtttggctga     4560

ctggcagtaa cctagtgaat ttctgaaaga tgagtaattt ctttggcaac cttcctcctc     4620

ccttactgaa ccactctccc acctcctggt ggtaccatta ttatagaagc cctctacagc     4680

ctgactttct ctccagcggt ccaaagttat cccctccttt acccctcatc caaagttccc     4740

actccttcag gacagctgct gtgcattaga tattaggggg gaaagtcatc tgtttaattt     4800

acacacttgc atgaattact gtatataaac tccttaactt cagggagcta ttttcattta     4860

gtgctaaaca agtaagaaaa ataagctcga gtgaatttct aaatgttgga atgttatggg     4920

atgtaaacaa tgtaaagtaa gacatctcag gatttcacca gaagttacag atgaggcact     4980

ggaagccacc aaattagcag gtgcaccttc tgtggctgtc ttgtttctga agtacttaaa     5040

cttccacaag agtgaatttg acctaggcaa gtttgttcaa aaggtagatc ctgagatgat     5100

ttggtcagat tgggataagg cccagcaatc tgcattttaa caagcacccc agtcactagg     5160

atgcagatgg accacacttt gagaaacacc acccatttct actttttgca ccttattttc     5220

tctgttcctg agcccccaca ttctctagga gaaacttaga ggaaaagggc acagacacta     5280

catatctaaa gctttggaca agtccttgac ctctataaac ttcagagtcc tcattataaa     5340

atgggaagac tgagctggag ttcagcagtg atgcttttag ttttaaaagt ctatgatctg     5400

gacttcctat aatacaaata cacaatcctc caagaatttg acttggaaaa aaatgtcaaa     5460

ggaaaacagg ttatctgccc atgtgcatat ggacaacctt gactaccctg gcctggcccg     5520

tggtggcagt ccagggctat ctgtactgtt tacagaatta ctttgtagtt gacaacacaa     5580

aacaaacaaa aaaggcataa aatgccagcg gtttatagaa aaaacagcat ggtattctcc     5640

agttaggtat gccagagtcc aattctttta acagctgtga gaatttgctg cttcattcca     5700

acaaaatttt atttaaaaaa aaaaaaaaaa gactggagaa actagtcatt agcttgataa     5760

agaatattta acagctagtg gtgctggtgt gtacctgaag ctccagctac ttgagagact     5820

gagacaggaa gatcgcttga gcccaggagt tcaagtccag cctaagcaac atagcaagac     5880

cctgtctcaa aaaaatgact atttaaaaag acaatgtggc caggcacggt ggctcacacc     5940

tgtaatccca acactttggg aggctgaggc cggtggatca cgaggtcagg agtttgagac     6000

tagcctggcc aacatggtga aaccccatct ctaataatat aaaaattagc tgggcgtagt     6060

agcaggtgcc tgtaatccca gttactcggg aagctgaggc aggagaatca cttgaacccg     6120

ggaggcagag gtttcagtga gccgagatcg cgccactgca ctccagcctg ggtgacaggg     6180

caagactctg tctcaaacaa acaaacaaaa aaaaagttag tactgtatat gtaaatacta     6240

gcttttcaat gtgctataca aacaattata gcacatcctt ccttttactc tgtctcacct     6300

cctttaggtg agtacttcct taaataagtg ctaaacatac atatacggaa cttgaaagct     6360

ttggttagcc ttgccttagg taatcagcct agtttacact gtttccaggg agtagttgaa     6420

ttactataaa ccattagcca cttgtctctg caccatttat cacaccagga cagggtctct     6480

caacctgggc gctactgtca tttggggcca ggtgattctt ccttgcaggg gctgtcctgt     6540

accttgtagg acagcagccc tgtcctagaa ggtatgttta gcagcattcc tggcctctag     6600

ctacccgatg ccagagcatg ctccccccgc agtcatgaca atcaaaaaat gtctccagac     6660

attgtcaaat gcctcctggg gggcagtatt tctcaagcac ttttaagcaa aggtaagtat     6720

tcatacaaga aatttagggg gaaaaaacat tgtttaaata aaagctatgt gttcctattc     6780

aacaatattt ttgctttaaa agtaagtaga gggcataaaa gatgtcatat tcaaatttcc     6840

atttcataaa tggtgtacag acaaggtcta tagaatgtgg taaaaacttg actgcaacac     6900

aaggcttata aaatagtaag atagtaaaat agcttatgaa gaaactacag agatttaaaa     6960

ttgtgcatga ctcatttcag cagcaaaata agaactccta actgaacaga aatttttcta     7020

cctagcaatg ttattcttgt aaaatagtta cctattaaaa ctgtgaagag taaaactaaa     7080

gccaatttat tatagtcaca caagtgatta tactaaaaat tattataaag gttataattt     7140

tataatgtat ttacctgtcc tgatatatag ctataaccca atatatgaaa atctcaaaaa     7200

ttaagacatc atcatacaga aggcaggatt ccttaaactg agatccctga tccatcttta     7260

atatttcaat ttgcacacat aaaacaatgc ccttttgtgt acattcaggc atacccattt     7320

taatcaattt gaaaggttaa tttaaacctc tagaggtgaa tgagaaacat gggggaaaag     7380

tatgaaatag gtgaaaatct taactatttc tttgaactct aaagactgaa actgtagcca     7440

ttatgtaaat aaagtttcat atgtacctgt ttattttggc agattaagtc aaaatatgaa     7500

tgtatatatt gcataactat gttagaattg tatatatttt aaagaaattg tcttggatat     7560

tttcctttat acataataga taagtctttt ttcaaatgtg gtgtttgatg tttttgatta     7620

aatgtgtttt gcctctttcc acaaaaactg taaaaataaa tgcatgtttg tacaaaaagt     7680

tgcagaattc atttgattta tgagaaacaa aaattaaatt gtagtcaaca gttagtagtt     7740

tttctcatat ccaagtataa caaacagaaa agtttcatta ttgtaaccca cttttttcat     7800

accacattat tgaatattgt tacaattgtt ttgaaaataa agccattttc tttgggcttt     7860

tataagttaa aaaaaaaa                                                   7878


<210>  2
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  3
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Pro Asp Phe Gln Leu Ser Ala Ser Phe Ser Pro Ala Thr Gln Pro 
1               5                   10                  15      


Cys Pro Ser Leu Ile Asp Val Val Val Val Cys Asp Glu Ser Asn Ser 
            20                  25                  30          


Ile Tyr Pro Trp Asp Ala Val Lys Asn Phe Leu Glu Lys Phe Val Gln 
        35                  40                  45              


Gly Leu Asp Ile Gly Pro Thr Lys Thr Gln Val Gly Leu Ile Gln Tyr 
    50                  55                  60                  


Ala Asn Asn Pro Arg Val Val Phe Asn Leu Asn Thr Tyr Lys Thr Lys 
65                  70                  75                  80  


Glu Glu Met Ile Val Ala Thr Ser Gln Thr Ser Gln Tyr Gly Gly Asp 
                85                  90                  95      


Leu Thr Asn Thr Phe Gly Ala Ile Gln Tyr Ala Arg Lys Tyr Ala Tyr 
            100                 105                 110         


Ser Ala Ala Ser Gly Gly Arg Arg Ser Ala Thr Lys Val Met Val Val 
        115                 120                 125             


Thr Asp Gly Glu Ser His Asp Gly Ser Met Leu Lys Ala Val Ile Asp 
    130                 135                 140                 


Gln Cys Asn His Asp Asn Ile Leu Arg Phe Gly Ile Ala Val Leu Gly 
145                 150                 155                 160 


Tyr Leu Asn Arg Asn Ala Leu Asp Thr Lys Asn Leu Ile Lys Glu Ile 
                165                 170                 175     


Lys Ala Ile Ala Ser Ile Pro Thr Glu Arg Tyr Phe Phe Asn Val Ser 
            180                 185                 190         


Asp Asp Glu Ala Ala Leu Leu Glu Lys Ala Gly Thr Leu Gly Glu Gln 
        195                 200                 205             


Ile Phe Ser Ile Glu Gly 
    210                 


<210>  4
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Gly Ser His His His His His His Gly Ser Pro Asp Phe Gln 
1               5                   10                  15      


Leu Ser Ala Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile 
            20                  25                  30          


Asp Val Val Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp 
        35                  40                  45              


Ala Val Lys Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly 
    50                  55                  60                  


Pro Thr Lys Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg 
65                  70                  75                  80  


Val Val Phe Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val 
                85                  90                  95      


Ala Thr Ser Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe 
            100                 105                 110         


Gly Ala Ile Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly 
        115                 120                 125             


Gly Arg Arg Ser Ala Thr Lys Val Met Val Val Thr Asp Gly Glu Ser 
    130                 135                 140                 


His Asp Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp 
145                 150                 155                 160 


Asn Ile Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn 
                165                 170                 175     


Ala Leu Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser 
            180                 185                 190         


Ile Pro Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Asp Glu Ala Ala 
        195                 200                 205             


Leu Leu Glu Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu 
    210                 215                 220                 


Gly 
225 


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  collagen-derived sequence that binds integrins; 

       Xaa at position 3 is hydroxyproline

<400>  5

Gly Phe Xaa Gly Glu Arg 
1               5       


<210>  6
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  6
cgggatcccc tgattttcag ctctcagcc                                         29


<210>  7
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  7
ccaagctttt aaccttcaat gctgaaaatt tgttctccta atgtccc                     47


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker for purification and cloning purposes

<400>  8

Met Arg Gly Ser His His His His His His Gly 
1               5                   10      


<210>  9
<211>  82
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (26)..(65)
<223>  contiguous nucleotides synthesized with equimolar quantities of 
       A, T, G and C

<400>  9
tctcggatcc tcagcgagtc gtctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnccgca tcgtcctccc ta                                                82


<210>  10
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  10
gggggaattc taatacgact cactataggg aggacgatgc gg                          42


<210>  11
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  11
tctcggatcc tcagcgagtc gtctg                                             25


<210>  12
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  aptamer

<400>  12
cgactaactt tagcgaacaa agctaacgac atctccacac                             40


<210>  13
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  aptamer

<400>  13
aacccggatc acacgcatcg cgtactacgt cccaactcgg                             40


