                         SEQUENCE LISTING

<110>  Georg-August-Universitt Gttingen Stiftung ffentlichen 
       Rechts, Universittsmedizin
 
<120>  New DPP8 and DPP9 peptide inhibitors

<130>  30A-124 022

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  SUMO1 Peptide 9

<400>  1

Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  SUMO2/SUMO3 corresponding sequence to SUMO1 Peptide 9

<400>  2

Gln Ile Arg Phe Arg Phe Asp Gly Gln Pro Ile Asn Glu Thr Asp 
1               5                   10                  15  


<210>  3
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  DDP9 arm motif

<400>  3

Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu Glu Arg Lys Thr 
1               5                   10                  15      


Asp Ser Tyr Arg Tyr 
            20      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  DPP8 arm motif

<400>  4

Val Glu Ile Ile His Val Thr Ser Pro Met Leu Glu Thr Arg Arg Ala 
1               5                   10                  15      


Asp Ser Phe Arg Tyr 
            20      


<210>  5
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  DPP4 arm motif

<400>  5

Ile Glu Tyr Ser Phe Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr 
1               5                   10                  15      


Val Arg Val Pro 
            20  


<210>  6
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser 
1               5                   10                  15      


Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr 
            20                  25                  30          


Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp 
        35                  40                  45              


Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg 
    50                  55                  60                  


Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys 
65                  70                  75                  80  


Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro 
                85                  90                  95      


His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu 
            100                 105                 110         


Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala 
        115                 120                 125             


Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr 
    130                 135                 140                 


Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg 
145                 150                 155                 160 


Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu 
                165                 170                 175     


Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg 
            180                 185                 190         


Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu 
        195                 200                 205             


Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro 
    210                 215                 220                 


Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val 
225                 230                 235                 240 


Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln 
                245                 250                 255     


Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr 
            260                 265                 270         


Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys 
        275                 280                 285             


Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile 
    290                 295                 300                 


Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro 
305                 310                 315                 320 


Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg 
                325                 330                 335     


Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln 
            340                 345                 350         


Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val 
        355                 360                 365             


Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala 
    370                 375                 380                 


Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg 
385                 390                 395                 400 


Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile 
                405                 410                 415     


Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val 
            420                 425                 430         


Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val 
        435                 440                 445             


Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly 
    450                 455                 460                 


Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe 
465                 470                 475                 480 


Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp 
                485                 490                 495     


Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile 
            500                 505                 510         


Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg 
        515                 520                 525             


His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe 
    530                 535                 540                 


Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser 
545                 550                 555                 560 


Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser 
                565                 570                 575     


His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr 
            580                 585                 590         


Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly 
        595                 600                 605             


Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met 
    610                 615                 620                 


Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe 
625                 630                 635                 640 


His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys 
                645                 650                 655     


Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val 
            660                 665                 670         


Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile 
        675                 680                 685             


Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val 
    690                 695                 700                 


Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly 
705                 710                 715                 720 


Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu 
                725                 730                 735     


Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg 
            740                 745                 750         


Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly 
        755                 760                 765             


Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro 
    770                 775                 780                 


Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met 
785                 790                 795                 800 


Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala 
                805                 810                 815     


Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu 
            820                 825                 830         


His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu 
        835                 840                 845             


Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr 
    850                 855                 860                 


Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr 
865                 870                 875                 880 


Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
                885                 890         


<210>  7
<211>  898
<212>  PRT
<213>  Homosapiens

<400>  7

Met Trp Lys Arg Ser Glu Gln Met Lys Ile Lys Ser Gly Lys Cys Asn 
1               5                   10                  15      


Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
            20                  25                  30          


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
        35                  40                  45              


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
    50                  55                  60                  


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
65                  70                  75                  80  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
                85                  90                  95      


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
            100                 105                 110         


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
        115                 120                 125             


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
    130                 135                 140                 


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
                165                 170                 175     


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
            180                 185                 190         


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
        195                 200                 205             


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
    210                 215                 220                 


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
225                 230                 235                 240 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
                245                 250                 255     


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
            260                 265                 270         


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
        275                 280                 285             


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
    290                 295                 300                 


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
305                 310                 315                 320 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
                325                 330                 335     


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
            340                 345                 350         


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
        355                 360                 365             


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
    370                 375                 380                 


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
385                 390                 395                 400 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
                405                 410                 415     


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
            420                 425                 430         


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
        435                 440                 445             


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
    450                 455                 460                 


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
465                 470                 475                 480 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
                485                 490                 495     


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
            500                 505                 510         


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
        515                 520                 525             


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
    530                 535                 540                 


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
545                 550                 555                 560 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
                565                 570                 575     


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
            580                 585                 590         


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
        595                 600                 605             


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
    610                 615                 620                 


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
625                 630                 635                 640 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
                645                 650                 655     


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
            660                 665                 670         


Gln Val Gln Leu Val Asn Asn Arg Phe Lys Gly Val Lys Tyr Phe Arg 
        675                 680                 685             


Leu Asn Thr Leu Ala Ser Leu Gly Tyr Val Val Val Val Ile Asp Asn 
    690                 695                 700                 


Arg Gly Ser Cys His Arg Gly Leu Lys Phe Glu Gly Ala Phe Lys Tyr 
705                 710                 715                 720 


Lys Met Gly Gln Ile Glu Ile Asp Asp Gln Val Glu Gly Leu Gln Tyr 
                725                 730                 735     


Leu Ala Ser Arg Tyr Asp Phe Ile Asp Leu Asp Arg Val Gly Ile His 
            740                 745                 750         


Gly Trp Ser Tyr Gly Gly Tyr Leu Ser Leu Met Ala Leu Met Gln Arg 
        755                 760                 765             


Ser Asp Ile Phe Arg Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp 
    770                 775                 780                 


Ile Phe Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp 
785                 790                 795                 800 


Gln Asn Glu Gln Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu 
                805                 810                 815     


Lys Phe Pro Ser Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu 
            820                 825                 830         


Asp Glu Asn Val His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu 
        835                 840                 845             


Val Arg Ala Gly Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg 
    850                 855                 860                 


His Ser Ile Arg Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu 
865                 870                 875                 880 


Leu His Tyr Leu Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys 
                885                 890                 895     


Val Ile 
        


<210>  8
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  9
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  SUMO1-i

<400>  9
ggauagcagu gagauucacu ucaaa                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  SUMO1-ii

<400>  10
ggaagaagau gugauugaag uuuau                                             25


<210>  11
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Glu Val Ile His Val Pro Ser Pro Ala Leu Glu Glu Arg Lys Thr 
1               5                   10                  15      


Asp Ser Tyr Arg 
            20  


<210>  12
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro 
1               5                   10                  15      


Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr 
            20                  25                  30  


<210>  13
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Tyr Glu Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr 
1               5                   10                  15      


Ser Pro Met Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr 
            20                  25                  30  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  14

Ser Leu Arg Phe Leu Phe Ala Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  15

Ser Leu Arg Phe Leu Tyr Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  16

Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn Arg 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  17

Ser Leu Arg Phe Leu Phe Asp Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  18

Ser Leu Arg Phe Leu Trp Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  19

Ser Leu Arg Phe Leu Val Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  20

Ser Leu Arg Phe Leu Ala Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  21

Ser Leu Arg Phe Leu Phe Glu Ala Gln Arg Ile Ala Asp Asn His 
1               5                   10                  15  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  22

Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10                  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  23

Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10              


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  24

Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10      


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  25

Phe Glu Gly Gln Arg Ile Ala Asp Asn His 
1               5                   10  


<210>  26
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  26

Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp 
1               5                   10              


<210>  27
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  27

Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile 
1               5                   10      


<210>  28
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  28

Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  29

Ser Leu Arg Phe Leu Phe Glu Gly Gln 
1               5                   


<210>  30
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  30

Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn 
1               5                   10              


<210>  31
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  31

Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp 
1               5                   10      


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  32

Phe Leu Phe Glu Gly Gln Arg Ile Ala 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  33

Phe Leu Phe Glu Gly Gln Arg Ile 
1               5               


<210>  34
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  34

Leu Phe Glu Gly Gln Arg 
1               5       


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL peptide variant

<400>  35

Phe Leu Ile Glu Gly Gln Arg Ile 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL minimal sequence

<400>  36

Ser Leu Arg Phe Leu Phe Glu Gly 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  37

Ser Leu Arg Phe Leu Tyr Glu Gly 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  38

Ser Leu Arg Phe Leu Phe Ala Gly 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  39

Ser Leu Arg Phe Leu Tyr Ala Gly 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  40

Thr Leu Arg Phe Leu Phe Glu Gly 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide


<220>
<221>  ACETYLATION
<222>  (1)..(1)

<400>  41

Ser Leu Arg Phe Leu Phe Glu Gly 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide


<220>
<221>  ACETYLATION
<222>  (1)..(1)

<400>  42

Ser Leu Arg Phe Leu Tyr Glu Gly 
1               5               


<210>  43
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  43

Ala Ala Ala Ser Leu Arg Phe Leu Tyr Glu Gly 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  44

Ser Leu Arg Phe Leu Tyr Glu Gly Ala Ala Ala 
1               5                   10      


<210>  45
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  45

Arg Arg Arg Arg Ser Leu Arg Phe Leu Phe Glu Gly 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  EIL variant peptide

<400>  46

Arg Arg Arg Arg Ser Leu Arg Phe Leu Tyr Ala Gly 
1               5                   10          


<210>  47
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide 1

<400>  47

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  48
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  DPP9/DPP8 inhibitor consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  wherein Xaa is Ser or Thr, preferably wherein Xaa is Ser

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  wherein Xaa is Phe, Tyr, Trp, Val or Ile, preferably wherein Xaa 
       is Phe, Tyr, Trp, or Val, more preferably wherein  Xaa is Phe or 
       Tyr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  wherein Xaa is Ala or Glu

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  wherein Xaa is Gly or Ala

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Gln

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Ile

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Ala

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Asp

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Asn

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is His

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  wherein Xaa is missing or wherein Xaa is any amino acid, 
       preferably wherein Xaa is Arg

<400>  48

Xaa Leu Arg Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  SUMO1 inhibitor consensus sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  wherein Xaa is any amino acid, preferably wherein Xaa is Val, Ile
       or Ala, preferably wherein Xaa is Val or Ile

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  wherein Xaa is Pro or Thr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  wherein Xaa is Ala or Met

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  wherein Xaa is Glu or Thr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  wherein Xaa is Lys or Arg

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  wherein Xaa is Thr or Ala

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  wherein Xaa is Tyr or Phe

<400>  49

Val Glu Xaa Ile His Val Xaa Ser Pro Xaa Leu Glu Xaa Arg Xaa Xaa 
1               5                   10                  15      


Asp Ser Xaa Arg 
            20  


