
                                SEQUENCE LISTING

<110> Huttner, Kenneth M.
      Kirby, Neil
      Schneider, Pascal
      Gaide, Olivier

<120> COMPOSITIONS AND METHODS FOR THE TREATMENT 
      OF ECTODERMAL DYSPLASIA

<130> 2003.1002PCT

<140> PCT/US2013/xxxx          
<141> 2013-11-13 

<150> 61/825,227          
<151> 2013-05-20

<150> 61/726,252         
<151> 2012-11-14

<160> 8

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> EDI200 monomer

<400> 1

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
 1               5                  10                  15
      
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
            20                  25                  30
          
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
        35                  40                  45
              
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
    50                  55                  60
                  
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
65                  70                  75                  80
  
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
                85                  90                  95
      
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
            100                 105                 110
         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
        115                 120                 125
             
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu
    130                 135                 140
                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
145                 150                 155                 160
 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                165                 170                 175
     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
            180                 185                 190
         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
        195                 200                 205
             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
    210                 215                 220
                 
Gly Lys Ala Asp Lys Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val
225                 230                 235                 240
 
His Leu Gln Gly Gln Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser
                245                 250                 255
     
Gly Gly Val Leu Asn Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val
            260                 265                 270
         
Phe Lys Leu His Pro Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly
        275                 280                 285
             
Thr Tyr Phe Ile Tyr Ser Gln Val Glu Val Tyr Tyr Ile Asn Phe Thr
    290                 295                 300
                 
Asp Phe Ala Ser Tyr Glu Val Val Val Asp Glu Lys Pro Phe Leu Gln
305                 310                 315                 320
 
Cys Thr Arg Ser Ile Glu Thr Gly Lys Thr Asn Tyr Asn Thr Cys Tyr
                325                 330                 335
     
Thr Ala Gly Val Cys Leu Leu Lys Ala Arg Gln Lys Ile Ala Val Lys
            340                 345                 350
         
Met Val His Ala Asp Ile Ser Ile Asn Met Ser Lys His Thr Thr Phe
        355                 360                 365       
      
Phe Gly Ala Ile Arg Leu Gly Glu Ala Pro Ala Ser
    370                 375                 380 

<210> 2
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 2
atttaggtga cactatag                                               18

<210> 3
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR Primer

<400> 3
tccagtgtgg tggaattcat ggctatcatc tacctc                           36

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward Primer

<400> 4
taatacgact cactataggg                                             20

<210> 5
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward Primer

<400> 5
ccgacggctc cttcttcc                                               18

<210> 6
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse Primer

<400> 6
ggaagaagga gccgtcgg                                               18

<210> 7
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse Primer

<400> 7
aggcacagtc gaggctga                                               18

<210> 8
<211> 7336
<212> DNA
<213> Artificial Sequence

<220> 
<223> p449 Plasmid

<400> 8
aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta 60
tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg 120
tcgacggatc gggagatctc ccgatcccct atggtgcact ctcagtacaa tctgctctga 180
tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg 240
cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct 300
gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca 360
ttgattattg actaggcttt tgcaaaaagc tttgcaaaga tggataaagt tttaaacaga 420
gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa ggagtgggaa ttggctccgg 480
tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc gagaagttgg ggggaggggt 540
cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt 600
gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc 660
cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg 720
ttcccgcggg cctggcctct ttacgggtta tggcccttgc gtgccttgaa ttacttccac 780
ctggctgcag tacgtgattc ttgatcccga gcttcgggtt ggaagtgggt gggagagttc 840
gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct ggcctgggcg 900
ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc tgtctcgctg ctttcgataa 960
gtctctagcc atttaaaatt tttgatgacc tgctgcgacg ctttttttct ggcaagatag 1020
tcttgtaaat gcgggccaag atctgcacac tggtatttcg gtttttgggg ccgcgggcgg 1080
cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc 1140
accgagaatc ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc 1200
gccgccgtgt atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg 1260
agcggaaaga tggccgcttc ccggccctgc tgcagggagc tcaaaatgga ggacgcggcg 1320
ctcgggagag cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc 1380
cgtcgcttca tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctc 1440
gagcttttgg agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc 1500
ccacactgag tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt 1560
ggaatttgcc ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca 1620
aagttttttt cttccatttc aggtgtcgtg aggaattagc ttggtactaa tacgactcac 1680
tatagggaga cccaagctgg ctaggtaagc ttggtaccga gctcggatcc actagtccag 1740
tgtggtggaa ttcatggcta tcatctacct catcctcctg ttcaccgctg tgcggggcaa 1800
aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct 1860
cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt 1920
ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt 1980
ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt 2040
ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa 2100
ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca 2160
gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca 2220
ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga 2280
gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgttgg actccgacgg 2340
ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt 2400
cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc 2460
cctgtctccg ggtaaagctg ataaagctgg aactcgagaa aaccagccag ctgtggtgca 2520
tctacagggc caagggtcag caattcaagt caagaatgat ctttcaggtg gagtgctcaa 2580
tgactggtct cgcatcacta tgaaccccaa ggtgtttaag ctacatcccc gcagcgggga 2640
gctggaggta ctggtggacg gcacctactt catctatagt caggtagaag tatactacat 2700
caacttcact gactttgcca gctatgaggt ggtggtggat gagaagccct tcctgcagtg 2760
cacacgcagc atcgagacgg gcaagaccaa ctacaacact tgctataccg caggcgtctg 2820
cctcctcaag gcccggcaga agatcgccgt caagatggtg cacgctgaca tctccatcaa 2880
catgagcaag cacaccacgt tctttggggc catcaggctg ggtgaagccc ctgcatccta 2940
gcggccgctc gagtctagag ggcccgcggt tcgaacaaaa actcatctca gaagaggatc 3000
tgaatatgca taccggtcat catcaccatc accattgagt ttaaacccgc tgatcagcct 3060
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga 3120
ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt 3180
gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg 3240
attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct tctgaggcgg 3300
aaagaaccag ctggggctct agggggtatc cccacgcgcc ctgtagcggc gcattaagcg 3360
cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 3420
ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 3480
taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 3540
aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 3600
ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 3660
tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 3720
ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttaattctgt ggaatgtgtg 3780
tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca 3840
tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat 3900
gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc 3960
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat 4020
ttatgcagag gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt 4080
ttttggaggc ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc 4140
tgatcaagag acaggatgag gatcgtttcg catgattgaa caagatggat tgcacgcagg 4200
ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg 4260
ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa 4320
gaccgacctg tccggtgccc tgaatgaact gcaggacgag gcagcgcggc tatcgtggct 4380
ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga 4440
ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc 4500
cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac 4560
ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc 4620
cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact 4680
gttcgccagg ctcaaggcgc gcatgcccga cggcgaggat ctcgtcgtga cccatggcga 4740
tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg 4800
ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga 4860
agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga 4920
ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgagcgg gactctgggg 4980
ttcgcgaaat gaccgaccaa gcgacgccca acctgccatc acgagatttc gattccaccg 5040
ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc tggatgatcc 5100
tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt attgcagctt 5160
ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 5220
tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgtataccgt 5280
cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt 5340
atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa gcctggggtg 5400
cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct ttccagtcgg 5460
gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga ggcggtttgc 5520
gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc 5580
ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata 5640
acgcaggaaa gaacatgtga gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg 5700
tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg 5760
tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg 5820
cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga 5880
agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc 5940
tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt 6000
aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact 6060
ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg 6120
cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt 6180
accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt 6240
ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct 6300
ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg 6360
gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt 6420
aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt 6480
gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc 6540
gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg 6600
cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc 6660
gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg 6720
gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca 6780
ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga 6840
tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct 6900
ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg 6960
cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca 7020
accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata 7080
cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct 7140
tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact 7200
cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa 7260
acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc 7320
atactcttcc tttttc                                                 7336
