                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  NOVEL GLP-1 RECEPTOR AGONISTS WITH CHOLESTEROL EFFLUX ACTIVITY

<130>  8599.204-WO

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  3
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  5
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr 
1               5                   10                  15      


Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln 
            20                  25                  30          


Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp 
        35                  40                  45              


Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu 
    50                  55                  60                  


Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu 
65                  70                  75                  80  


Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys 
                85                  90                  95      


Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met 
            100                 105                 110         


Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu 
        115                 120                 125             


Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu 
    130                 135                 140                 


Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg 
145                 150                 155                 160 


Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala 
                165                 170                 175     


Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr 
            180                 185                 190         


His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys 
        195                 200                 205             


Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser 
    210                 215                 220                 


Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu 
225                 230                 235                 240 


Asn Thr Gln 
            


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mimetic peptide

<400>  6

Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu 
1               5                   10                  15      


Ala Phe 
        


<210>  7
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mimetic peptide

<400>  7

Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu 
1               5                   10                  15      


Ala Phe Pro Asp Trp Ala Lys Ala Ala Tyr Asp Lys Ala Ala Glu Lys 
            20                  25                  30          


Ala Lys Glu Ala Ala 
        35          


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mimetic peptide

<400>  8

Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 
1               5                   10                  15      


Leu Lys Gln Lys Leu Lys 
            20          


<210>  9
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Glu Ala Val Lys Glu Phe Ile Ala Trp Leu Val Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu 
        


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

His Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Lys Ala Ala Arg Glu Phe Val Gln Trp Leu Leu Glu Lys Val Lys Glu 
            20                  25                  30          


Phe Leu 
        


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

His Ala Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Glu Phe Ile Glu Trp Leu Lys Asn Lys Val Leu Glu 
            20                  25                  30          


Phe Leu 
        


<210>  12
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula I


<220>
<221>  SITE
<222>  (1)..(1)
<223>  may be His or desamino-His

<220>
<221>  SITE
<222>  (2)..(2)
<223>  may be Ala, Gly, Ser or Aib

<220>
<221>  SITE
<222>  (3)..(3)
<223>  may be Glu, Asp, Gln or His

<220>
<221>  SITE
<222>  (6)..(6)
<223>  may be Phe, Tyr or Leu

<220>
<221>  SITE
<222>  (8)..(8)
<223>  may be Ser, Asn or His

<220>
<221>  SITE
<222>  (10)..(10)
<223>  may be Val, Tyr, Leu, Ile or Met

<220>
<221>  SITE
<222>  (11)..(11)
<223>  may be Ser or Thr

<220>
<221>  SITE
<222>  (12)..(12)
<223>  may be Ser, Lys, Arg, Glu, Asn or Gln

<220>
<221>  SITE
<222>  (13)..(13)
<223>  may be Tyr or Gln

<220>
<221>  SITE
<222>  (14)..(14)
<223>  may be Leu, Met, Tyr or Lys

<220>
<221>  SITE
<222>  (15)..(15)
<223>  may be Glu, Asp or Gln

<220>
<221>  SITE
<222>  (16)..(16)
<223>  may be Gly, Ser, Glu, Lys or Aib

<220>
<221>  SITE
<222>  (17)..(17)
<223>  may be Gln, Glu, Lys, Trp, Arg or Asp

<220>
<221>  SITE
<222>  (18)..(18)
<223>  may be Ala, Aib, Lys or Arg

<220>
<221>  SITE
<222>  (19)..(19)
<223>  may be Ala, Val, Phe, His, Leu, Met, Trp, Tyr, Ile or Aib

<220>
<221>  SITE
<222>  (20)..(20)
<223>  may be Lys, Asn, Glu, Arg, His, Gly or Val

<220>
<221>  SITE
<222>  (21)..(21)
<223>  may be Glu, Asp, Gln, Ala, His, Gly, Arg, Lys, Aib or Leu

<220>
<221>  SITE
<222>  (23)..(23)
<223>  may be Ile or Val

<220>
<221>  SITE
<222>  (24)..(24)
<223>  may be Ala, Val, Gln, Ile, Trp, Aib, Glu or Arg

<220>
<221>  SITE
<222>  (25)..(25)
<223>  may be Trp, Gln, Lys or His

<220>
<221>  SITE
<222>  (27)..(27)
<223>  may be Val, Met, Ile, Leu, Thr, Arg or Lys

<220>
<221>  SITE
<222>  (28)..(28)
<223>  may be Lys, Glu, Asn, Asp, Gln, His, Gly or Arg

<220>
<221>  SITE
<222>  (29)..(29)
<223>  may be Gly, Lys, Arg, His, Ser, Thr or Aib

<220>
<221>  SITE
<222>  (30)..(30)
<223>  may be Gly, Aib, Val, Leu, Ala, His, Ile, Met, Trp, Tyr, Phe;

<220>
<221>  SITE
<222>  (31)..(31)
<223>  may be Gly, Ala, Glu, Aib, His, Arg, Leu, Pro or Lys

<220>
<221>  SITE
<222>  (32)..(32)
<223>  may be Glu, Ser, Asp, His, amide or absent

<220>
<221>  SITE
<222>  (33)..(33)
<223>  may be Phe, Leu, His, Ala, Ser, Ile, Met, Val, Trp, Tyr, amide or
       absent

<220>
<221>  SITE
<222>  (34)..(34)
<223>  may be Leu, Phe, Val, His, Gly, Ala, Ile, Met, Trp, Tyr, amide or
       absent

<220>
<221>  SITE
<222>  (35)..(35)
<223>  may be Glu, Ala, amide or absent

<220>
<221>  SITE
<222>  (36)..(36)
<223>  may be Leu, Pro, Lys, amide or absent

<220>
<221>  SITE
<222>  (37)..(37)
<223>  may be Leu, Pro, Val, amide or absent

<220>
<221>  SITE
<222>  (38)..(38)
<223>  may be Lys, Amide or absent

<220>
<221>  SITE
<222>  (39)..(39)
<223>  may be Glu, amide or absent

<220>
<221>  SITE
<222>  (40)..(40)
<223>  may be Phe, Ile, amide or absent

<220>
<221>  SITE
<222>  (41)..(41)
<223>  may be Ile, amide or absent

<220>
<221>  SITE
<222>  (42)..(42)
<223>  may be Ala, amide or absent

<220>
<221>  SITE
<222>  (43)..(43)
<223>  may be Trp, amide or absent

<220>
<221>  SITE
<222>  (44)..(44)
<223>  may be amide or absent

<400>  12

Xaa Xaa Xaa Gly Thr Xaa Thr Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  


<210>  13
<211>  29
<212>  PRT
<213>  Heloderma suspectum

<400>  13

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25                  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mimetic peptide

<400>  14

Glu Leu Arg Glu Lys Leu Glu Ala Trp Phe Glu Leu Phe Arg Glu Phe 
1               5                   10                  15      


Leu Glu Arg Phe 
            20  


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mimetic peptide

<400>  15

Glu Val Arg Ser Lys Leu Glu Glu Trp Phe Ala Ala Phe Arg Glu Phe 
1               5                   10                  15      


Ala Glu Glu Phe Leu Ala Arg Leu Lys Ser 
            20                  25      


