               SEQUENCE LISTING

<110> MorphoSys AG

<120> ANTI-STAPHYLOCOCCAL ANTIBODIES

<160> 138

<170> BiSSAP 1.2

<210> 1
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> MprF

<400> 1
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Ala Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asp 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Val Val Ser Phe Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Ala His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Ile Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Phe 
385                 390                 395                 400 
Ala Met Ile Ser Ile Leu Leu Ile Thr Val Ala Thr Phe Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Ala Ile Ile Phe Val Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Val Arg Met 
        435                 440                 445             
Arg Asn Ile Val Ala Met Leu Leu Phe Ser Leu Phe Ile Leu Tyr Val 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Leu Tyr Ala Leu Asp Ile Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Arg Tyr Tyr Phe Trp Leu Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Ile Gly Met Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Lys Ile Glu Asp Cys Glu Glu 
        515                 520                 525             
Ile Ile Asn Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asn Lys Thr Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Leu Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Glu Phe Asn Glu Glu Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Glu Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 2
<211> 19
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 1

<400> 2
Glu Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys 
1               5                   10                  15      
Ile Asn Arg 
            

<210> 3
<211> 14
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 2

<400> 3
Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His Phe 
1               5                   10                  

<210> 4
<211> 14
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 3

<400> 4
Ser Met Val Arg Pro Pro Asp Lys Asn Asn Arg Phe Val Gly 
1               5                   10                  

<210> 5
<211> 13
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 4

<400> 5
Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val 
1               5                   10              

<210> 6
<211> 10
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 5

<400> 6
Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
1               5                   10  

<210> 7
<211> 13
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> Loop 6

<400> 7
Asp Ile Tyr Thr Ile Glu Met His Thr Ser Val Leu Arg 
1               5                   10              

<210> 8
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> ML-1 HCDR1

<400> 8
Gly Gly Thr Phe Asn Ser Tyr Ala Ile His 
1               5                   10  

<210> 9
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 HCDR2

<400> 9
Gly Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 10
<211> 13
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 HCDR3

<400> 10
Asp Gln Tyr Thr Tyr Asp Tyr Tyr Arg Ala Phe Asp Tyr 
1               5                   10              

<210> 11
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 LCDR1

<400> 11
Arg Ala Ser Gln Ser Val Arg Asp Asn Leu Ala 
1               5                   10      

<210> 12
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 LCDR2

<400> 12
Gly Ala Ser Asn Arg Ala Thr 
1               5           

<210> 13
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 LCDR3

<400> 13
Gln Gln Tyr Asp His Ser Pro Arg Thr 
1               5                   

<210> 14
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 VL

<400> 14
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asp Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp His Ser Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 15
<211> 122
<212> PRT
<213> synthetic construct

<220> 
<223> ML1 VH

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gln Tyr Thr Tyr Asp Tyr Tyr Arg Ala Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 16
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="ML1 VL"
      /organism="synthetic construct"

<400> 16
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gtctgttcgt gacaacctgg cttggtacca gcagaaaccg     120

ggccaggccc cgcgtctatt aatctacggt gcttctaacc gtgcgaccgg cattccggcg     180

cgttttagcg gcagcggatc cggcaccgat ttcaccctga ccattagcag cctggaaccg     240

gaagactttg cggtgtatta ttgccagcag tacgaccatt ctccgcgtac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 17
<211> 366
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="ML1 VH"
      /organism="synthetic construct"

<400> 17
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgtttaac tcttacgcta tccattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcttcggcat cgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaccag     300

tacacttacg actactaccg tgctttcgat tactggggcc aaggcaccct ggtgactgtt     360

agctca                                                                366


<210> 18
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 HCDR1

<400> 18
Ser Tyr Ala Met Ser 
1               5   

<210> 19
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 HCDR2

<400> 19
Ile Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 20
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 HCDR3

<400> 20
Thr Ala Thr Ser Gly Ser Arg Gly Tyr Phe Asp Tyr 
1               5                   10          

<210> 21
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 LCDR1

<400> 21
Arg Ala Ser Gln Asp Ile Ser Ser Trp Leu Asn 
1               5                   10      

<210> 22
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 LCDR2

<400> 22
Gly Ala Ser Thr Leu Gln Ser 
1               5           

<210> 23
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 LCDR3

<400> 23
Gln Gln His Tyr Thr Ser Pro Val Thr 
1               5                   

<210> 24
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 VL

<400> 24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Phe Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ser Pro Val 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 25
<211> 121
<212> PRT
<213> synthetic construct

<220> 
<223> ML4 VH

<400> 25
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ile Ile Ser Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Ala Thr Ser Gly Ser Arg Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 26
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="ML4 VL"
      /organism="synthetic construct"

<400> 26
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacatttct tcttggctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatcttcggt gcttctactc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag cattacactt ctccggttac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 27
<211> 363
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..363
<223> /mol_type="unassigned DNA"
      /note="ML4 VH"
      /organism="synthetic construct"

<400> 27
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt cacctttcgt tcttacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccatt atctcttacg acggttcttc tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactgct     300

acttctggtt ctcgtggtta cttcgattac tggggccaag gcaccctggt gactgttagc     360

tca                                                                   363


<210> 28
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 HCDR1

<400> 28
Ser Tyr Ala Met Asn 
1               5   

<210> 29
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 HCDR2

<400> 29
Val Ile Ser Ser Asp Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 30
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 HCDR3

<400> 30
Glu Ser Tyr Tyr Ile Gly Trp Asp Tyr 
1               5                   

<210> 31
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 LCDR1

<400> 31
Arg Ala Ser Gln Arg Val Ser Ser Ser Phe Leu Ala 
1               5                   10          

<210> 32
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 LCDR2

<400> 32
Leu Ala Ser Asn Arg Ala Thr 
1               5           

<210> 33
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 LCDR3

<400> 33
Leu Gln Tyr Gly His Tyr Pro Pro Thr 
1               5                   

<210> 34
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 VL

<400> 34
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Leu Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly His Tyr Pro 
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 

<210> 35
<211> 118
<212> PRT
<213> synthetic construct

<220> 
<223> MC1 VH

<400> 35
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Ser Asp Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ser Tyr Tyr Ile Gly Trp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 36
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="MC1 VL"
      /organism="synthetic construct"

<400> 36
gatatcgtgc tgacccagag cccggcgacc ctgagcctga gcccgggtga acgtgccacc      60

ctgagctgca gagcgagcca gcgtgtttct tcttctttcc tggcttggta ccagcagaaa     120

ccgggccagg ccccgcgtct attaatctac ctggcttcta accgtgcgac cggcattccg     180

gcgcgtttta gcggcagcgg atccggcacc gatttcaccc tgaccattag cagcctggaa     240

ccggaagact ttgcggtgta ttattgcctg cagtacggtc attacccgcc gacctttggc     300

cagggcacga aagttgaaat taaacgtacg                                      330


<210> 37
<211> 354
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="MC1 VH"
      /organism="synthetic construct"

<400> 37
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgcta tgaactgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttctg acggttctga cacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgaatct     300

tactacatcg gttgggatta ctggggccaa ggcaccctgg tgactgttag ctca           354


<210> 38
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 HCDR1

<400> 38
Ser Tyr Ala Ile Ser 
1               5   

<210> 39
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 HCDR2

<400> 39
Gly Ile Ile Pro Ile Phe Gly Met Ala Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 40
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 HCDR3

<400> 40
Ser Leu Phe Gly Arg Ala Tyr 
1               5           

<210> 41
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 LCDR1

<400> 41
Arg Ala Ser Gln Ser Ile Ser Ser Phe Leu Ala 
1               5                   10      

<210> 42
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 LCDR2

<400> 42
Asp Ala Ser Ser Leu Gln Ser 
1               5           

<210> 43
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 LCDR3

<400> 43
Leu Gln Ala Asp Ser Thr Ser Tyr Thr 
1               5                   

<210> 44
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 VL

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ala Asp Ser Thr Ser Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 45
<211> 116
<212> PRT
<213> synthetic construct

<220> 
<223> MC41 VH

<400> 45
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Met Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Leu Phe Gly Arg Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 46
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC41 VL"
      /organism="synthetic construct"

<400> 46
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca gtctatttct tctttcctgg cttggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgac gcttcttctc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgcctgcag gctgactcta cttcttacac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 47
<211> 348
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..348
<223> /mol_type="unassigned DNA"
      /note="MC41 VH"
      /organism="synthetic construct"

<400> 47
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgtttaac tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcttcggcat ggcgacttac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgttctctg     300

ttcggtcgtg cttactgggg ccaaggcacc ctggtgactg ttagctca                  348


<210> 48
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 HCDR1

<400> 48
Ser Tyr Ala Met His 
1               5   

<210> 49
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 HCDR2

<400> 49
Val Ile Ser Ser Val Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 50
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 HCDR3

<400> 50
Gly Gly Leu Asp Val 
1               5   

<210> 51
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 LCDR1

<400> 51
Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      

<210> 52
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 LCDR2

<400> 52
Ala Ala Ser Arg Leu Gln Ser 
1               5           

<210> 53
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 LCDR3

<400> 53
Gln Gln Gly Asp Ser Thr Pro Phe Thr 
1               5                   

<210> 54
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 VL

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ser Thr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 55
<211> 114
<212> PRT
<213> synthetic construct

<220> 
<223> MC42 VH

<400> 55
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Ser Val Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 56
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC42 VL"
      /organism="synthetic construct"

<400> 56
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacatttct aaatacctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgct gcttctcgtc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag ggtgactcta ctccgttcac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 57
<211> 342
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..342
<223> /mol_type="unassigned DNA"
      /note="MC42 VH"
      /organism="synthetic construct"

<400> 57
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgcta tgcattgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttctg ttggttcttc tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtggt     300

ctggacgttt ggggccaagg caccctggtg actgttagct ca                        342


<210> 58
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 HCDR1

<400> 58
Asp His Thr Ile Ser 
1               5   

<210> 59
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 HCDR2

<400> 59
Gly Ile Ile Pro Ile Val Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 60
<211> 12
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 HCDR3

<400> 60
Glu Tyr Tyr Val Pro Asp Ser Gly Trp Phe Asp Tyr 
1               5                   10          

<210> 61
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 LCDR1

<400> 61
Arg Ala Ser Gln Asp Ile Ser Asp Tyr Leu Val 
1               5                   10      

<210> 62
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 LCDR2

<400> 62
Asp Ala Ser Asn Leu Gln Ser 
1               5           

<210> 63
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 LCDR3

<400> 63
Gln Gln Tyr Tyr His Tyr Arg Thr 
1               5               

<210> 64
<211> 108
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 VL

<400> 64
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asp Tyr 
            20                  25                  30          
Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr His Tyr Arg Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             

<210> 65
<211> 121
<212> PRT
<213> synthetic construct

<220> 
<223> MC43 VH

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp His 
            20                  25                  30          
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Tyr Tyr Val Pro Asp Ser Gly Trp Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 66
<211> 324
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="MC43 VL"
      /organism="synthetic construct"

<400> 66
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacatttct gactacctgg tttggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgac gcttctaacc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag tactaccatt accgtacctt tggccagggc     300

acgaaagttg aaattaaacg tacg                                            324


<210> 67
<211> 363
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..363
<223> /mol_type="unassigned DNA"
      /note="MC43 VH"
      /organism="synthetic construct"

<400> 67
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct gaccacacta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcat cgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaatac     300

tacgttccgg actctggttg gttcgattac tggggccaag gcaccctggt gactgttagc     360

tca                                                                   363


<210> 68
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 HCDR1

<400> 68
Ser Tyr Ala Ile Ser 
1               5   

<210> 69
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 HCDR2

<400> 69
Gly Ile Val Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 70
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 HCDR3

<400> 70
Val Arg Tyr Gly Tyr Trp Asp Val 
1               5               

<210> 71
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 LCDR1

<400> 71
Arg Ala Ser Gln Asp Ile Ala Asn Trp Leu Asn 
1               5                   10      

<210> 72
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 LCDR2

<400> 72
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 73
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 LCDR3

<400> 73
Gln Gln Tyr Ile Ser Leu Pro Ile Thr 
1               5                   

<210> 74
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 VL

<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Trp 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Leu Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 75
<211> 117
<212> PRT
<213> synthetic construct

<220> 
<223> MC51 VH

<400> 75
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Val Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Arg Tyr Gly Tyr Trp Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 76
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC51 VL"
      /organism="synthetic construct"

<400> 76
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacattgct aactggctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgct gcttcttctc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag tacatctctc tgccgatcac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 77
<211> 351
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..351
<223> /mol_type="unassigned DNA"
      /note="MC51 VH"
      /organism="synthetic construct"

<400> 77
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcgttccga tcttcggcac tgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgttcgt     300

tacggctact gggatgtttg gggccaaggc accctggtga ctgttagctc a              351


<210> 78
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 HCDR1

<400> 78
Ser Tyr Ala Val His 
1               5   

<210> 79
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 HCDR2

<400> 79
Val Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 80
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 HCDR3

<400> 80
Asp His Gly Tyr Phe Asp Tyr 
1               5           

<210> 81
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 LCDR1

<400> 81
Arg Ala Ser Gln Thr Ile Ser Asn His Leu Gly 
1               5                   10      

<210> 82
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 LCDR2

<400> 82
Thr Ala Ser Asn Leu Gln Ser 
1               5           

<210> 83
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 LCDR3

<400> 83
Gln Gln Tyr Ser His Ser Ser Tyr Thr 
1               5                   

<210> 84
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 VL

<400> 84
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asn His 
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser His Ser Ser Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 85
<211> 116
<212> PRT
<213> synthetic construct

<220> 
<223> MC52 VH

<400> 85
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Gly Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 86
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC52 VL"
      /organism="synthetic construct"

<400> 86
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca gactatttct aaccatctgg gttggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacact gcttctaacc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag tactctcatt cttcttacac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 87
<211> 348
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..348
<223> /mol_type="unassigned DNA"
      /note="MC52 VH"
      /organism="synthetic construct"

<400> 87
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgctg ttcattgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctctggtc gtggtggttc tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgaccat     300

ggttacttcg actactgggg ccaaggcacc ctggtgactg ttagctca                  348


<210> 88
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 HCDR1

<400> 88
Ile Tyr Ala Ile Ser 
1               5   

<210> 89
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 HCDR2

<400> 89
Gly Ile Ile Pro Glu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 90
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 HCDR3

<400> 90
Ser Gln Ile Tyr Thr Leu Ser Tyr Pro Lys Trp Phe Asp Phe 
1               5                   10                  

<210> 91
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 LCDR1

<400> 91
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 92
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 LCDR2

<400> 92
Asp Ala Ser Asn Leu Gln Ser 
1               5           

<210> 93
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 LCDR3

<400> 93
Leu Gln Tyr Leu Gln Ser Pro Lys Thr 
1               5                   

<210> 94
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 VL

<400> 94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Leu Gln Ser Pro Lys 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 95
<211> 123
<212> PRT
<213> synthetic construct

<220> 
<223> MC61 VH

<400> 95
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Glu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gln Ile Tyr Thr Leu Ser Tyr Pro Lys Trp Phe Asp Phe 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 96
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC61 VL"
      /organism="synthetic construct"

<400> 96
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacatttct aactacctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgac gcttctaacc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgcctgcag tacctgcagt ctccgaaaac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 97
<211> 369
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..369
<223> /mol_type="unassigned DNA"
      /note="MC61 VH"
      /organism="synthetic construct"

<400> 97
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct atctacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccgg aattcggcac tgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgttctcag     300

atctacactc tgtcttaccc gaaatggttc gacttctggg gccaaggcac cctggtgact     360

gttagctca                                                             369


<210> 98
<211> 5
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 HCDR1

<400> 98
Ser Tyr Ala Ile Ser 
1               5   

<210> 99
<211> 17
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 HCDR2

<400> 99
Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 100
<211> 23
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 HCDR3

<400> 100
Ser Leu Pro Tyr Arg Ser Asp Leu Tyr Gly Phe Ser Arg Trp Ser Tyr 
1               5                   10                  15      
His Arg Val Gly Met Asp Val 
            20              

<210> 101
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 LCDR1

<400> 101
Arg Ala Ser Gln Asp Ile Ser Asn Thr Leu Asn 
1               5                   10      

<210> 102
<211> 7
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 LCDR2

<400> 102
Ala Ala Ser Thr Leu Gln Ser 
1               5           

<210> 103
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 LCDR3

<400> 103
Gln Gln Val Gly Ser Phe Pro Tyr Thr 
1               5                   

<210> 104
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 VL

<400> 104
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Thr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Gly Ser Phe Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 105
<211> 132
<212> PRT
<213> synthetic construct

<220> 
<223> MC62 VH

<400> 105
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Leu Pro Tyr Arg Ser Asp Leu Tyr Gly Phe Ser Arg Trp 
            100                 105                 110         
Ser Tyr His Arg Val Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             
Thr Val Ser Ser 
    130         

<210> 106
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="MC62 VL"
      /organism="synthetic construct"

<400> 106
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca ggacatttct aacactctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgct gcttctactc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag gttggttctt tcccgtacac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 107
<211> 396
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..396
<223> /mol_type="unassigned DNA"
      /note="MC62 VH"
      /organism="synthetic construct"

<400> 107
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcctgggcat cgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgttctctg     300

ccgtaccgtt ctgacctgta cggtttctct cgttggtctt accatcgtgt tggtatggat     360

gtttggggcc aaggcaccct ggtgactgtt agctca                               396


<210> 108
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> Pep1

<400> 108
Cys Glu Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser 
1               5                   10                  15      
Lys Ile Asn Arg 
            20  

<210> 109
<211> 15
<212> PRT
<213> synthetic construct

<220> 
<223> Pep2

<400> 109
Cys Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His Phe 
1               5                   10                  15  

<210> 110
<211> 15
<212> PRT
<213> synthetic construct

<220> 
<223> Pep3

<400> 110
Cys Ser Met Val Arg Pro Pro Asp Lys Asn Asn Arg Phe Val Gly 
1               5                   10                  15  

<210> 111
<211> 15
<212> PRT
<213> synthetic construct

<220> 
<223> Pep4

<400> 111
Cys Gly Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val 
1               5                   10                  15  

<210> 112
<211> 13
<212> PRT
<213> synthetic construct

<220> 
<223> Pep5

<400> 112
Cys Gly Gly Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
1               5                   10              

<210> 113
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> Pep6

<400> 113
Cys Asp Ile Tyr Thr Ile Glu Met His Thr Ser Val Leu Arg 
1               5                   10                  

<210> 114
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> MRSA252

<400> 114
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Val Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asn 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Ala Val Ser Leu Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Tyr Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Val His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Leu Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Tyr 
385                 390                 395                 400 
Ala Met Ile Ser Ile Ile Leu Ile Ile Val Ala Thr Leu Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Val Ile Ile Phe Ala Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Ile Arg Met 
        435                 440                 445             
Arg Asn Leu Val Ala Met Leu Leu Phe Ser Ile Phe Ile Leu Tyr Ile 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Phe Tyr Ala Leu Asp Val Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Lys Tyr Tyr Phe Trp Ile Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Val Gly Ala Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Asn Ile Glu Glu Cys Glu Glu 
        515                 520                 525             
Ile Ile Asp Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asp Lys Asn Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Ile Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Gln Phe Asn Glu Thr Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Asn Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 115
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> MSSA479

<400> 115
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Val Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asp 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Val Val Ser Phe Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Ala His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Ile Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Phe 
385                 390                 395                 400 
Ala Met Ile Ser Ile Leu Leu Ile Thr Val Ala Thr Phe Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Ala Ile Ile Phe Val Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Val Arg Met 
        435                 440                 445             
Arg Asn Ile Val Ala Met Leu Leu Phe Ser Leu Phe Ile Leu Tyr Val 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Leu Tyr Ala Leu Asp Ile Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Arg Tyr Tyr Phe Trp Leu Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Ile Gly Met Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Lys Ile Glu Asp Cys Glu Glu 
        515                 520                 525             
Ile Ile Asn Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asn Lys Thr Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Leu Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Gln Phe Asn Glu Glu Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Glu Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 116
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> MW2

<400> 116
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Val Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asp 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Val Val Ser Phe Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Ala His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Ile Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Phe 
385                 390                 395                 400 
Ala Met Ile Ser Ile Leu Leu Ile Thr Val Ala Thr Phe Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Ala Ile Ile Phe Val Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Val Arg Met 
        435                 440                 445             
Arg Asn Ile Val Ala Met Leu Leu Phe Ser Leu Phe Ile Leu Tyr Val 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Leu Tyr Ala Leu Asp Ile Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Arg Tyr Tyr Phe Trp Leu Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Ile Gly Met Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Lys Ile Glu Asp Cys Glu Glu 
        515                 520                 525             
Ile Ile Asn Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asn Lys Thr Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Leu Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Gln Phe Asn Glu Glu Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Glu Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 117
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> N315

<400> 117
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Ala Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asp 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Val Val Ser Phe Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Ala His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Ile Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Phe 
385                 390                 395                 400 
Ala Met Ile Ser Ile Leu Leu Ile Thr Val Ala Thr Phe Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Ala Ile Ile Phe Val Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Val Arg Met 
        435                 440                 445             
Arg Asn Ile Val Ala Met Leu Leu Phe Ser Leu Phe Ile Leu Tyr Val 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Leu Tyr Ala Leu Asp Ile Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Arg Tyr Tyr Phe Trp Leu Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Ile Gly Met Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Lys Ile Glu Asp Cys Glu Glu 
        515                 520                 525             
Ile Ile Asn Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asn Lys Thr Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Leu Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Gln Phe Asn Glu Glu Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Glu Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 118
<211> 840
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> USA300

<400> 118
Met Asn Gln Glu Val Lys Asn Lys Ile Phe Ser Ile Leu Lys Ile Thr 
1               5                   10                  15      
Phe Ala Thr Ala Leu Phe Ile Phe Val Ala Ile Thr Leu Tyr Arg Glu 
            20                  25                  30          
Leu Ser Gly Ile Asn Phe Lys Asp Thr Leu Val Glu Phe Ser Lys Ile 
        35                  40                  45              
Asn Arg Met Ser Leu Val Leu Leu Phe Ile Gly Gly Gly Ala Ser Leu 
    50                  55                  60                  
Val Ile Leu Ser Met Tyr Asp Val Ile Leu Ser Arg Ala Leu Lys Met 
65                  70                  75                  80  
Asp Ile Ser Leu Gly Lys Val Leu Arg Val Ser Tyr Ile Ile Asn Ala 
                85                  90                  95      
Leu Asn Ala Ile Val Gly Phe Gly Gly Phe Ile Gly Ala Gly Val Arg 
            100                 105                 110         
Ala Met Val Tyr Lys Asn Tyr Thr His Asp Lys Lys Lys Leu Val His 
        115                 120                 125             
Phe Ile Ser Leu Ile Leu Ile Ser Met Leu Thr Gly Leu Ser Leu Leu 
    130                 135                 140                 
Ser Leu Leu Ile Val Phe His Val Phe Asp Ala Ser Leu Ile Leu Asp 
145                 150                 155                 160 
Lys Ile Thr Trp Val Arg Trp Val Leu Tyr Val Val Ser Phe Phe Leu 
                165                 170                 175     
Pro Leu Phe Ile Ile Tyr Ser Met Val Arg Pro Pro Asp Lys Asn Asn 
            180                 185                 190         
Arg Phe Val Gly Leu Tyr Cys Thr Leu Val Ser Cys Val Glu Trp Leu 
        195                 200                 205             
Ala Ala Ala Val Val Leu Tyr Phe Cys Gly Val Ile Val Asp Ala His 
    210                 215                 220                 
Val Ser Phe Met Ser Phe Ile Ala Ile Phe Ile Ile Ala Ala Leu Ser 
225                 230                 235                 240 
Gly Leu Val Ser Phe Ile Pro Gly Gly Phe Gly Ala Phe Asp Leu Val 
                245                 250                 255     
Val Leu Leu Gly Phe Lys Thr Leu Gly Val Pro Glu Glu Lys Val Leu 
            260                 265                 270         
Leu Met Leu Leu Leu Tyr Arg Phe Ala Tyr Tyr Phe Val Pro Val Ile 
        275                 280                 285             
Ile Ala Leu Ile Leu Ser Ser Phe Glu Phe Gly Thr Ser Ala Lys Lys 
    290                 295                 300                 
Tyr Ile Glu Gly Ser Lys Tyr Phe Ile Pro Ala Lys Asp Val Thr Ser 
305                 310                 315                 320 
Phe Leu Met Ser Tyr Gln Lys Asp Ile Ile Ala Lys Ile Pro Ser Leu 
                325                 330                 335     
Ser Leu Ala Ile Leu Val Phe Phe Thr Ser Met Ile Phe Phe Val Asn 
            340                 345                 350         
Asn Leu Thr Ile Val Tyr Asp Ala Leu Tyr Asp Gly Asn His Leu Thr 
        355                 360                 365             
Tyr Tyr Ile Leu Leu Ala Ile His Thr Ser Ala Cys Leu Leu Leu Leu 
    370                 375                 380                 
Leu Asn Val Val Gly Ile Tyr Lys Gln Ser Arg Arg Ala Ile Ile Phe 
385                 390                 395                 400 
Ala Met Ile Ser Ile Leu Leu Ile Thr Val Ala Thr Phe Phe Thr Tyr 
                405                 410                 415     
Ala Ser Tyr Ile Leu Ile Thr Trp Leu Ala Ile Ile Phe Val Leu Leu 
            420                 425                 430         
Ile Val Ala Phe Arg Arg Ala Arg Arg Leu Lys Arg Pro Val Arg Met 
        435                 440                 445             
Arg Asn Ile Val Ala Met Leu Leu Phe Ser Leu Phe Ile Leu Tyr Val 
    450                 455                 460                 
Asn His Ile Phe Ile Ala Gly Thr Leu Tyr Ala Leu Asp Ile Tyr Thr 
465                 470                 475                 480 
Ile Glu Met His Thr Ser Val Leu Arg Tyr Tyr Phe Trp Leu Thr Ile 
                485                 490                 495     
Leu Ile Ile Ala Ile Ile Ile Gly Met Ile Ala Trp Leu Phe Asp Tyr 
            500                 505                 510         
Gln Phe Ser Lys Val Arg Ile Ser Ser Lys Ile Glu Asp Cys Glu Glu 
        515                 520                 525             
Ile Ile Asn Gln Tyr Gly Gly Asn Tyr Leu Ser His Leu Ile Tyr Ser 
    530                 535                 540                 
Gly Asp Lys Gln Phe Phe Thr Asn Glu Asn Lys Thr Ala Phe Leu Met 
545                 550                 555                 560 
Tyr Arg Tyr Lys Ala Ser Ser Leu Val Val Leu Gly Asp Pro Leu Gly 
                565                 570                 575     
Asp Glu Asn Ala Phe Asp Glu Leu Leu Glu Ala Phe Tyr Asn Tyr Ala 
            580                 585                 590         
Glu Tyr Leu Gly Tyr Asp Val Ile Phe Tyr Gln Val Thr Asp Gln His 
        595                 600                 605             
Met Pro Leu Tyr His Asn Phe Gly Asn Gln Phe Phe Lys Leu Gly Glu 
    610                 615                 620                 
Glu Ala Ile Ile Asp Leu Thr Gln Phe Ser Thr Ser Gly Lys Lys Arg 
625                 630                 635                 640 
Arg Gly Phe Arg Ala Thr Leu Asn Lys Phe Asp Glu Leu Asn Ile Ser 
                645                 650                 655     
Phe Glu Ile Ile Glu Pro Pro Phe Ser Thr Glu Phe Ile Asn Glu Leu 
            660                 665                 670         
Gln His Val Ser Asp Leu Trp Leu Asp Asn Arg Gln Glu Met His Phe 
        675                 680                 685             
Ser Val Gly Glu Phe Asn Glu Glu Tyr Leu Ser Lys Ala Pro Ile Gly 
    690                 695                 700                 
Val Met Arg Asn Glu Glu Asn Glu Val Ile Ala Phe Cys Ser Leu Met 
705                 710                 715                 720 
Pro Thr Tyr Phe Asn Asp Ala Ile Ser Val Asp Leu Ile Arg Trp Leu 
                725                 730                 735     
Pro Glu Leu Asp Leu Pro Leu Met Asp Gly Leu Tyr Leu His Met Leu 
            740                 745                 750         
Leu Trp Ser Lys Glu Gln Gly Tyr Thr Lys Phe Asn Met Gly Met Ala 
        755                 760                 765             
Thr Leu Ser Asn Val Gly Gln Leu His Tyr Ser Tyr Leu Arg Glu Arg 
    770                 775                 780                 
Leu Ala Gly Arg Val Phe Glu His Phe Asn Gly Leu Tyr Arg Phe Gln 
785                 790                 795                 800 
Gly Leu Arg Arg Tyr Lys Ser Lys Tyr Asn Pro Asn Trp Glu Pro Arg 
                805                 810                 815     
Phe Leu Val Tyr Arg Lys Asp Asn Ser Leu Trp Glu Ser Leu Ser Lys 
            820                 825                 830         
Val Met Arg Val Ile Arg His Lys 
        835                 840 

<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 119
Phe Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   

<210> 120
<211> 19
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 120
Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      
Val Lys Gly 
            

<210> 121
<211> 9
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 121
Tyr Pro Tyr Pro Gly Tyr Phe Asp Leu 
1               5                   

<210> 122
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 122
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Tyr 
1               5                   10      

<210> 123
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 123
Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro Ser 
1               5                   10      

<210> 124
<211> 10
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 124
Gln Thr Trp Val Ser Ser Ile Ser Ala Phe 
1               5                   10  

<210> 125
<211> 110
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 125
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Val Ser Ser Ile Ser Ala 
                85                  90                  95      
Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210> 126
<211> 118
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 126
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Pro Tyr Pro Gly Tyr Phe Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 127
<211> 330
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="synthetic construct"

<400> 127
agctatgaac tgacccagcc gccgagcgtt agcgttagcc caggccagac cgccagcatt      60

acctgtagcg gcgacaaact gggcgacaaa tacgcctact ggtatcagca gaaaccgggc     120

cagagcccgg tgctggttat ctatcaggat agcaaacgcc cgagcggcat tccagaacgc     180

tttagcggca gcaacagcgg caacaccgcc accctgacca ttagcggcac ccaggccgaa     240

gacgaagccg attattactg ccagacttgg gtttcttcta tctctgcttt cgtgtttggc     300

ggcggtacca agctgaccgt gctgggccag                                      330


<210> 128
<211> 354
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="synthetic construct"

<400> 128
gaagtgcagc tgctggaaag cggtggcggt ctggtgcagc caggtggtag cctgcgcctg      60

agctgtgccg caagcggctt tacctttagc agctatgcca ttagctgggt gcgccaagca     120

ccaggcaaag gcctggaatg ggtgagcgcc attagcggca gcggtggcag cacctattat     180

gccgagagcg tgaaaggtcg ctttaccatt agtcgcgata acagcaaaaa caccctgtat     240

ctgcaaatga acagcctgcg ggcagaagat accgcagttt attattgcgc gcgttaccct     300

taccctggtt atttcgacct gtggggccag ggcaccctgg ttactgtctc gagc           354


<210> 129
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR1

<400> 129
Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10      

<210> 130
<211> 20
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR2

<400> 130
Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val 
1               5                   10                  15      
Ser Val Lys Ser 
            20  

<210> 131
<211> 14
<212> PRT
<213> synthetic construct

<220> 
<223> HCDR3

<400> 131
Ser Ala Glu Pro Ser Tyr Ala Tyr Tyr His Gly Phe Asp Tyr 
1               5                   10                  

<210> 132
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR1

<400> 132
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 133
<211> 11
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR2

<400> 133
Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser 
1               5                   10      

<210> 134
<211> 8
<212> PRT
<213> synthetic construct

<220> 
<223> LCDR3

<400> 134
Gln Gln Arg Ile Ile Phe Pro Gln 
1               5               

<210> 135
<211> 109
<212> PRT
<213> synthetic construct

<220> 
<223> VL

<400> 135
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ile Ile Phe Pro Gln 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 136
<211> 126
<212> PRT
<213> synthetic construct

<220> 
<223> VH

<400> 136
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Ser Ala Glu Pro Ser Tyr Ala Tyr Tyr His Gly 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 137
<211> 327
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="synthetic construct"

<400> 137
gatattcagc tgacccagag cccgagcttt ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgcc gcgccagcca gggcattagc agctatctgg cctggtatca gcagaaaccg     120

ggcaaagccc cgaaactgct gatctatgcc gccagcaccc tgcaaagcgg cgtgccaagc     180

cgctttagcg gcagcggtag cggcaccgag ttcaccctga ccattagcag cctgcaaccg     240

gaagactttg ccacctatta ttgccagcag cgtatcatct tcccgcagac cttcggccag     300

ggtaccaaag tggaaatcaa gcggacc                                         327


<210> 138
<211> 378
<212> DNA
<213> synthetic construct

<220> 
<221> source
<222> 1..378
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="synthetic construct"

<400> 138
caggtgcagc tgcaacagag cggcccaggc ctggttaaac cgagccagac cctgagcctg      60

acctgcgcca ttagcggcga tagcgttagc agcaacagcg ccgcctggaa ctggattcgc     120

cagagcccga gccgcggtct ggaatggctg ggccgcacct attatcgcag caaatggtac     180

aacgattacg ccgttagcgt gaaaagccgc attaccatta acccggatac cagcaaaaac     240

cagttcagcc tgcaactgaa cagcgtgacc ccggaagata ccgccgtgta ttactgcgcg     300

cgtagcgcag agcctagcta cgcatactat cacggttttg actattgggg ccagggcacc     360

ctggttactg tctcgagc                                                   378


