                         SEQUENCE LISTING

<110>  ChemTex
       Carbonell, Pablo
       Faulon, Jean-Loup
       Capasso, Elisabetta
       Volpati, Laura
       
 
<120>  A MICROBIAL ORGANISM FOR PRODUCING TEREPHTHALATE FROM BIOMASS



<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  315
<212>  PRT
<213>  Comomonas testosteronis

<400>  1

Met Thr Ile Val His Arg Arg Leu Ala Leu Ala Ile Gly Asp Pro His 
1               5                   10                  15      


Gly Ile Gly Pro Glu Ile Ala Leu Lys Ala Leu Gln Gln Leu Ser Ala 
            20                  25                  30          


Thr Glu Arg Ser Leu Ile Lys Val Tyr Gly Pro Trp Ser Ala Leu Glu 
        35                  40                  45              


Gln Ala Ala Gln Ile Cys Gln Met Glu Ser Leu Leu Gln Asp Leu Ile 
    50                  55                  60                  


His Glu Glu Ala Gly Ser Leu Ala Gln Pro Ala Gln Trp Gly Glu Ile 
65                  70                  75                  80  


Thr Pro Gln Ala Gly Leu Ser Thr Val Gln Ser Ala Thr Ala Ala Ile 
                85                  90                  95      


Arg Ala Cys Glu Asn Gly Glu Val Asp Ala Val Ile Ala Cys Pro His 
            100                 105                 110         


His Glu Thr Ala Ile His Arg Ala Gly Ile Ala Phe Ser Gly Tyr Pro 
        115                 120                 125             


Ser Leu Leu Ala Asn Val Leu Gly Met Asn Glu Asp Glu Val Phe Leu 
    130                 135                 140                 


Met Leu Val Gly Ala Gly Leu Arg Ile Val His Val Thr Leu His Glu 
145                 150                 155                 160 


Ser Val Arg Ser Ala Leu Glu Arg Leu Ser Pro Gln Leu Val Val Asp 
                165                 170                 175     


Ala Val Asp Ala Ala Val Gln Thr Cys Thr Leu Leu Gly Val Pro Lys 
            180                 185                 190         


Pro Gln Val Ala Val Phe Gly Ile Asn Pro His Ala Ser Glu Gly Gln 
        195                 200                 205             


Leu Phe Gly Leu Glu Asp Ser Gln Ile Thr Ala Pro Ala Val Glu Thr 
    210                 215                 220                 


Leu Arg Lys Cys Gly Leu Ala Val Asp Gly Pro Met Gly Ala Asp Met 
225                 230                 235                 240 


Val Leu Ala Gln Arg Lys His Asp Leu Tyr Val Ala Met Leu His Asp 
                245                 250                 255     


Gln Gly His Ile Pro Ile Lys Leu Leu Ala Pro Asn Gly Ala Ser Ala 
            260                 265                 270         


Leu Ser Ile Gly Gly Arg Val Val Leu Ser Ser Val Gly His Gly Ser 
        275                 280                 285             


Ala Met Asp Ile Ala Gly Arg Gly Val Ala Asp Ser Thr Ala Leu Leu 
    290                 295                 300                 


Arg Thr Ile Ala Leu Leu Gly Ala Gln Pro Gly 
305                 310                 315 


<210>  2
<211>  504
<212>  PRT
<213>  Nicotiana  tabacum

<400>  2

Met Gln Phe Phe Ser Leu Val Ser Ile Phe Leu Phe Leu Ser Phe Leu 
1               5                   10                  15      


Phe Leu Leu Arg Lys Trp Lys Asn Ser Asn Ser Gln Ser Lys Lys Leu 
            20                  25                  30          


Pro Pro Gly Pro Trp Lys Ile Pro Ile Leu Gly Ser Met Leu His Met 
        35                  40                  45              


Ile Gly Gly Glu Pro His His Val Leu Arg Asp Leu Ala Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Leu Met His Leu Gln Leu Gly Glu Ile Ser Ala Val Val Val 
65                  70                  75                  80  


Thr Ser Arg Asp Met Ala Lys Glu Val Leu Lys Thr His Asp Val Val 
                85                  90                  95      


Phe Ala Ser Arg Pro Lys Ile Val Ala Met Asp Ile Ile Cys Tyr Asn 
            100                 105                 110         


Gln Ser Asp Ile Ala Phe Ser Pro Tyr Gly Asp His Trp Arg Gln Met 
        115                 120                 125             


Arg Lys Ile Cys Val Met Glu Leu Leu Asn Ala Lys Asn Val Arg Ser 
    130                 135                 140                 


Phe Ser Ser Ile Arg Arg Asp Glu Val Val Arg Leu Ile Asp Ser Ile 
145                 150                 155                 160 


Arg Ser Asp Ser Ser Ser Gly Glu Leu Val Asn Phe Thr Gln Arg Ile 
                165                 170                 175     


Ile Trp Phe Ala Ser Ser Met Thr Cys Arg Ser Ala Phe Gly Gln Val 
            180                 185                 190         


Leu Lys Gly Gln Asp Ile Phe Ala Lys Lys Ile Arg Glu Val Ile Gly 
        195                 200                 205             


Leu Ala Glu Gly Phe Asp Val Val Asp Ile Phe Pro Thr Tyr Lys Phe 
    210                 215                 220                 


Leu His Val Leu Ser Gly Met Lys Arg Lys Leu Leu Asn Ala His Leu 
225                 230                 235                 240 


Lys Val Asp Ala Ile Val Glu Asp Val Ile Asn Glu His Lys Lys Asn 
                245                 250                 255     


Leu Ala Ala Gly Lys Ser Asn Gly Ala Leu Gly Gly Glu Asp Leu Ile 
            260                 265                 270         


Asp Val Leu Leu Arg Leu Met Asn Asp Thr Ser Leu Gln Phe Pro Ile 
        275                 280                 285             


Thr Asn Asp Asn Ile Lys Ala Val Ile Val Asp Met Phe Ala Ala Gly 
    290                 295                 300                 


Thr Glu Thr Ser Ser Thr Thr Thr Val Trp Ala Met Ala Glu Met Met 
305                 310                 315                 320 


Lys Asn Pro Ser Val Phe Thr Lys Ala Gln Ala Glu Val Arg Glu Ala 
                325                 330                 335     


Phe Arg Asp Lys Val Ser Phe Asp Glu Asn Asp Val Glu Glu Leu Lys 
            340                 345                 350         


Tyr Leu Lys Leu Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Ser 
        355                 360                 365             


Pro Leu Leu Val Pro Arg Glu Cys Arg Glu Asp Thr Asp Ile Asn Gly 
    370                 375                 380                 


Tyr Thr Ile Pro Ala Lys Thr Lys Val Met Val Asn Val Trp Ala Leu 
385                 390                 395                 400 


Gly Arg Asp Pro Lys Tyr Trp Asp Asp Ala Glu Ser Phe Lys Pro Glu 
                405                 410                 415     


Arg Phe Glu Gln Cys Ser Val Asp Phe Phe Gly Asn Asn Phe Glu Phe 
            420                 425                 430         


Leu Pro Phe Gly Gly Gly Arg Arg Ile Cys Pro Gly Met Ser Phe Gly 
        435                 440                 445             


Leu Ala Asn Leu Tyr Leu Pro Leu Ala Gln Leu Leu Tyr His Phe Asp 
    450                 455                 460                 


Trp Lys Leu Pro Thr Gly Ile Met Pro Arg Asp Leu Asp Leu Thr Glu 
465                 470                 475                 480 


Leu Ser Gly Ile Thr Ile Ala Arg Lys Gly Gly Leu Tyr Leu Asn Ala 
                485                 490                 495     


Thr Pro Tyr Gln Pro Ser Arg Glu 
            500                 


<210>  3
<211>  598
<212>  PRT
<213>  Cupriavidus pinatubonensis

<400>  3

Met Ala Leu Thr Ile Glu Thr Asp Val Leu Val Val Gly Thr Gly Pro 
1               5                   10                  15      


Ala Gly Ala Ser Ala Gly Ala Leu Leu Ala Arg Tyr Gly Val Arg Thr 
            20                  25                  30          


Met Leu Ile Asn Lys Tyr Asn Trp Thr Ala Pro Thr Pro Arg Ala His 
        35                  40                  45              


Ile Thr Asn Gln Arg Thr Met Glu Ile Leu Arg Asp Leu Gly Leu Glu 
    50                  55                  60                  


Ala Glu Ala Arg Leu Tyr Ala Ala Pro Asn Asp Leu Met Gly Glu Asn 
65                  70                  75                  80  


Thr Ile Cys Ala Ser Leu Ala Gly Glu Glu Phe Gly Arg Ile Arg Thr 
                85                  90                  95      


Trp Gly Thr Asp Val Arg Arg Arg Ala Asp Tyr Asp Glu Cys Ser Pro 
            100                 105                 110         


Thr Ser Met Cys Asp Leu Pro Gln Asn Tyr Leu Glu Pro Ile Leu Val 
        115                 120                 125             


Lys Ser Ala Ala Leu Asp Gly Cys Lys Val Arg Phe Asp Thr Glu Tyr 
    130                 135                 140                 


Leu Gly His Glu Gln Asp Ala Asp Gly Val Ser Ser Arg Leu Arg Asp 
145                 150                 155                 160 


Arg Leu Asn Gly Glu Glu Phe Thr Val Arg Ser Lys Tyr Leu Ile Gly 
                165                 170                 175     


Ala Asp Gly Ala Asn Ser Arg Val Val Ser Asp Leu Asp Leu Pro Leu 
            180                 185                 190         


Glu Gly Thr Met Gly Lys Ser Gly Ser Ile Asn Leu Leu Phe Glu Ala 
        195                 200                 205             


Asp Leu Asp Arg Tyr Val Ala His Arg Pro Ser Val Leu Tyr Trp Val 
    210                 215                 220                 


Ile Gln Pro Gly Ser Asp Ile Gly Gly Leu Gly Ile Gly Val Val Arg 
225                 230                 235                 240 


Met Val Arg Pro Trp Asn Lys Trp Leu Ala Ile Trp Gly Tyr Asp Val 
                245                 250                 255     


Glu Gln Gly Pro Pro Glu Ile Ser Glu Ser Phe Ala Arg Arg Ile Val 
            260                 265                 270         


His Asn Leu Ile Gly Asp Asp Ser Val Pro Leu Lys Ile Glu Gly Ile 
        275                 280                 285             


Ser Thr Trp Thr Val Asn Asp Met Tyr Ala Thr Arg Leu Gln Gln Gly 
    290                 295                 300                 


Arg Val Phe Cys Ala Gly Asp Ala Val His Arg His Pro Pro Thr Asn 
305                 310                 315                 320 


Gly Leu Gly Ser Asn Thr Ser Ile Gln Asp Ser Phe Asn Leu Ala Trp 
                325                 330                 335     


Lys Ile Ala Met Val Leu Asn Gly Thr Ala Asp Glu Ser Leu Leu Asp 
            340                 345                 350         


Thr Tyr Thr Ile Glu Arg Ala Pro Ile Ala Lys Gln Val Val Cys Arg 
        355                 360                 365             


Ala Asn Lys Ser Leu Glu Asp Phe Pro Pro Ile Ala Met Ala Leu Gly 
    370                 375                 380                 


Leu Pro Gln Ala Lys Ser Ala Asp Glu Met Lys Ser Asn Met Ala Arg 
385                 390                 395                 400 


Arg Lys Glu Pro Gly Pro Glu Ala Gln Ala Gln Arg Thr Arg Leu Arg 
                405                 410                 415     


Glu Ala Ile Ala Gly Thr Asn Tyr Val Tyr Asn Ala His Gly Val Glu 
            420                 425                 430         


Met Asn Gln Arg Tyr Asp Ser Pro Ala Ile Val Ala Asp Asn Ser Pro 
        435                 440                 445             


Asp Glu Val Phe Arg Asp Val Glu Leu Tyr His Gln Ala Ser Thr Arg 
    450                 455                 460                 


Pro Gly Ala Pro Met Pro His Val Trp Val Tyr Ala Ser Gly Asp Gly 
465                 470                 475                 480 


His Arg Ile Ser Thr Lys Asp Leu Cys Gly Lys Gly Asn Phe Thr Leu 
                485                 490                 495     


Phe Thr Gly Ile Gly Gly Ala Ala Trp Gln Asp Ala Ala Ala Ala Val 
            500                 505                 510         


Ser Arg Gln Leu Gly Val Ala Val Thr Val Arg Ile Ile Gly Pro Gly 
        515                 520                 525             


Gln Ala Tyr Glu Asp His Tyr Gly Asp Phe Ala Arg Ile Ser Glu Ile 
    530                 535                 540                 


Ile Asp Thr Gly Ala Ile Leu Val Arg Pro Asp Phe His Val Ala Tyr 
545                 550                 555                 560 


Arg Ala Thr Ser Leu Pro Ala Asp Ala Ala Gly Asp Leu Val Ser Ala 
                565                 570                 575     


Met Arg Arg Ile Leu Gly Arg Gln Ser Glu Arg Ser Ser Ala Leu Arg 
            580                 585                 590         


Val Thr Ser Arg Ala Ile 
        595             


<210>  4
<211>  638
<212>  PRT
<213>  Arthrobacter aurescens

<400>  4

Met Gln Phe His His His Gly Tyr Val Ser Gly Asp Pro Arg Val Gln 
1               5                   10                  15      


Pro Ala Ala Gly Val Gly Gln Asp Arg Pro Ala Glu Leu Pro Asp Gln 
            20                  25                  30          


Val Asp Val Leu Ile Val Gly Thr Gly Pro Ala Gly Met Leu Ala Ala 
        35                  40                  45              


Ala Gln Leu Ser Gln Phe Pro Asn Val Thr Thr Arg Ile Ile Glu Arg 
    50                  55                  60                  


Arg Pro Gly Arg Leu Ala Ile Gly Gln Ala Asp Gly Ile Gln Ala Arg 
65                  70                  75                  80  


Ser Val Glu Thr Phe Gln Ala Phe Gly Phe Ala Glu Arg Ile Ile Ala 
                85                  90                  95      


Glu Ala Tyr Ala Ile Thr Glu Met Ala Phe Trp Lys Pro Asp Val Asn 
            100                 105                 110         


Asp Ser Ser Arg Ile Val Arg Thr Ala Arg Thr Pro Asp Asp Pro Ala 
        115                 120                 125             


Gly Ile Ser Glu Phe Pro His Leu Ile Val Asn Gln Ala Arg Val Leu 
    130                 135                 140                 


Asp Tyr Phe Ala Glu Phe Met Ala Asn Ala Pro Thr Arg Met Thr Pro 
145                 150                 155                 160 


Asp Tyr Gly Tyr Glu Phe Gln Gly Leu Glu Val Ala Asp Glu Gly Glu 
                165                 170                 175     


Tyr Pro Val Thr Val Thr Leu Leu His Thr Ser Gly Pro Asn Glu Gly 
            180                 185                 190         


Gln Glu Lys Ile Val Lys Ala Lys Tyr Val Val Gly Ala Asp Gly Ala 
        195                 200                 205             


Arg Ser Lys Val Arg Gln Ala Ile Gly Cys Thr Leu Ala Gly Asp Ala 
    210                 215                 220                 


Ala Asn His Ala Trp Gly Val Met Asp Ala Leu Ala Val Thr Asp Phe 
225                 230                 235                 240 


Pro Asp Ile Arg Thr Lys Cys Ala Ile Gln Ser Gly Glu Gly Gly Ser 
                245                 250                 255     


Ile Leu Leu Ile Pro Arg Glu Gly Gly His Leu Phe Arg Met Tyr Val 
            260                 265                 270         


Asp Leu Gly Glu Val Asp Pro Asn Asp Lys Gly Ala Val Arg Asn Thr 
        275                 280                 285             


Thr Ile Glu Glu Ile Ile Gly Lys Ala Asn Glu Ile Leu His Pro Tyr 
    290                 295                 300                 


Thr Leu Asp Val Arg Asn Val Ala Trp His Ser Val Tyr Glu Val Gly 
305                 310                 315                 320 


His Arg Leu Thr Asp Arg Phe Asp Asp Val Leu Pro Glu Asp Arg Gly 
                325                 330                 335     


Thr Arg Thr Pro Arg Val Phe Ile Thr Gly Asp Ala Cys His Thr His 
            340                 345                 350         


Ser Ala Lys Ala Gly Gln Gly Met Asn Val Ser Met Gln Asp Gly Phe 
        355                 360                 365             


Asn Ile Ala Trp Lys Leu Gly His Val Leu Glu Gly Arg Ser His Glu 
    370                 375                 380                 


Ser Leu Leu Ser Thr Tyr Ser Glu Glu Arg Gln Val Val Ala Lys Asn 
385                 390                 395                 400 


Leu Ile Asp Phe Asp Lys Glu Trp Ser Thr Met Met Ala Lys Lys Pro 
                405                 410                 415     


Glu Glu Phe Ala Ser Pro Ser Glu Leu Glu Asp Phe Tyr Val Ser Thr 
            420                 425                 430         


Ala Glu Phe Pro Ala Gly Phe Met Thr Gln Tyr Ala Pro Ser Met Leu 
        435                 440                 445             


Val Gly Thr Ala Glu Asn Gln Ser Phe Ala Thr Gly Phe Pro Val Gly 
    450                 455                 460                 


Lys Arg Phe Lys Ser Ala Pro Val Val Arg Val Ala Asp Thr Asn Pro 
465                 470                 475                 480 


Val Gln Leu Gly His His Ala Thr Ala Asp Gly Arg Trp Arg Ile Tyr 
                485                 490                 495     


Val Phe Ala Asp Ala Ala Gln Pro Gly Thr Gly Ser Ala Thr Asp Leu 
            500                 505                 510         


Leu Ala Glu Trp Phe Ala Ser Ser Ser Glu Ser Pro Leu Ala Ala Thr 
        515                 520                 525             


Pro Gln Gly Ala Asp Leu Asp Ala Trp Phe Asp Val Lys Val Val Tyr 
    530                 535                 540                 


Gln Gln Asp His His Asn Val Asp Ile Gly Ala Val Pro Ala Val Phe 
545                 550                 555                 560 


Lys Pro Gln Val Gly Pro Phe Lys Leu Ala Asp Tyr Glu Lys Val Tyr 
                565                 570                 575     


Gly Thr Asp Leu Ser Ala Asp Ile Phe Asp Leu Arg Gly Leu Asp Arg 
            580                 585                 590         


Arg Gly Ala Val Val Ile Val Arg Pro Asp Gln Tyr Val Ala Asn Val 
        595                 600                 605             


Leu Pro Leu Thr Ala Thr Ala Glu Leu Gly Ala Phe Phe Ala Pro Leu 
    610                 615                 620                 


Leu Pro Asn Lys Arg Leu Glu Ser Ala Ser Pro Ala Ser Ala 
625                 630                 635             


<210>  5
<211>  519
<212>  PRT
<213>  Aspergillus fumigatus

<400>  5

Met Ile Thr Asp Leu Leu Ser Leu Gln Asn Ala Gly Leu Ile Leu Leu 
1               5                   10                  15      


Gly Leu Ile Ala Val Tyr Tyr Val Ile Pro Tyr Leu Gln Lys Trp His 
            20                  25                  30          


Leu His Asp Ile Pro Ser Pro Arg Phe Ala Ala Phe Ser Asn Leu Trp 
        35                  40                  45              


Leu Leu Leu Gln Ala Arg Arg Gly Arg Arg Phe Leu Lys Val Asp Glu 
    50                  55                  60                  


Ala His Lys Lys Tyr Gly Lys Leu Val Arg Ile Ala Pro Lys His Val 
65                  70                  75                  80  


Ser Ile Ala Asp Asp Ala Ala Ile Gln Ala Ile Tyr Gly His Gly Asn 
                85                  90                  95      


Gly Phe Leu Lys Ala Asp Phe Tyr Asp Ala Phe Val Ser Ile Arg Arg 
            100                 105                 110         


Gly Leu Phe Asn Thr Arg Asp Arg Ala Glu His Thr Arg Lys Arg Lys 
        115                 120                 125             


Thr Val Ser His Thr Phe Ser Met Lys Ser Ile Gly Gln Phe Glu Gln 
    130                 135                 140                 


Tyr Ile His Gln Asn Val Glu Leu Phe Val Gln Gln Trp Thr Lys Leu 
145                 150                 155                 160 


Ala Lys Leu Asn Gly Asn Pro Arg Ser Gly Tyr Ala Thr Ile Asp Ala 
                165                 170                 175     


Leu Asn Trp Phe Asn Tyr Leu Ala Phe Asp Ile Ile Gly Asp Leu Ala 
            180                 185                 190         


Phe Gly Ala Pro Phe Gly Met Leu Glu Lys Gly Lys Asp Ile Ala Glu 
        195                 200                 205             


Met Arg Lys Thr Pro Asp Ser Glu Pro Thr Tyr Val Gln Ala Val Glu 
    210                 215                 220                 


Val Leu Asn Arg Arg Gly Glu Val Ser Ala Thr Leu Gly Cys Leu Pro 
225                 230                 235                 240 


Arg Leu Ile Pro Tyr Ala Lys Tyr Leu Pro Asp Arg Phe Phe Lys Asp 
                245                 250                 255     


Gly Val Gln Ala Val Glu Asn Leu Ala Gly Ile Ala Val Ala Arg Val 
            260                 265                 270         


Asn Glu Arg Leu Lys Pro Glu Val Met Glu Lys Asn Thr Arg Val Asp 
        275                 280                 285             


Leu Leu Ser Arg Leu Met Glu Gly Lys Asp Ser Asn Gly Asn Lys Leu 
    290                 295                 300                 


Gly Arg Glu Glu Leu Thr Ala Glu Ala Leu Thr Gln Leu Ile Ala Gly 
305                 310                 315                 320 


Ser Asp Thr Thr Ser Asn Thr Thr Cys Ala Ile Leu Tyr Trp Cys Met 
                325                 330                 335     


Ser Thr Pro Gly Val Ile Pro Lys Leu Gln Lys Val Leu Asp Glu Ala 
            340                 345                 350         


Ile Pro Asp Asp Val Asp Val Pro Thr His Ala Met Val Lys Asp Ile 
        355                 360                 365             


Pro Tyr Leu Gln Trp Val Ile Trp Glu Thr Met Arg Ile His Ser Thr 
    370                 375                 380                 


Ser Ala Met Gly Leu Pro Arg Glu Ile Pro Pro Gly Asn Pro Pro Val 
385                 390                 395                 400 


Thr Ile Ser Gly His Thr Phe Tyr Pro Gly Asp Val Val Ser Val Pro 
                405                 410                 415     


Ser Tyr Thr Ile His Arg Ser Lys Glu Ile Trp Gly Pro Asp Ala Glu 
            420                 425                 430         


Lys Phe Val Pro Glu Arg Trp Asp Pro Ala Arg Leu Thr Ala Arg Gln 
        435                 440                 445             


Lys Ala Ala Phe Ile Pro Phe Ser Thr Gly Pro Arg Ala Cys Val Gly 
    450                 455                 460                 


Arg Asn Val Ala Glu Met Glu Leu Leu Val Met Thr Gly Thr Ile Phe 
465                 470                 475                 480 


Arg Leu Phe Glu Phe Glu Met Gln Gln Asp Gly Pro Met Glu Thr Arg 
                485                 490                 495     


Glu Gly Phe Leu Arg Lys Pro Leu Gly Leu Ile Val Gly Met Lys Arg 
            500                 505                 510         


Arg Ala Val His Ala Ser Val 
        515                 


<210>  6
<211>  163
<212>  PRT
<213>  Burkholderia  thailandensis

<400>  6

Met Ser Thr Ile Asp Ile Ala Arg Ile Gln Ala Phe Leu Tyr Arg Glu 
1               5                   10                  15      


Ser Arg Leu Leu Asp Asp Lys Ala Trp Asp Ala Trp Leu Asp Cys Tyr 
            20                  25                  30          


His Pro His Val Val Phe Trp Met Pro Ser Trp Asp Asp Ala Asp Ala 
        35                  40                  45              


Leu Val Thr Asp Pro Gln Arg Glu Ile Ser Leu Ile Tyr Tyr Pro Asn 
    50                  55                  60                  


Arg Gln Gly Leu Glu Asp Arg Val Phe Arg Ile Lys Thr Glu Arg Ser 
65                  70                  75                  80  


Ser Ala Thr Met Pro Asp Thr Arg Thr Ser His Asn Leu Ala Asn Val 
                85                  90                  95      


Glu His Glu Ser Ala Asp Gly Asp Val His Val Val Arg Phe Asn Trp 
            100                 105                 110         


His Thr Leu Ser Tyr Arg Tyr Lys Thr Val Ser Ser Tyr Phe Gly Met 
        115                 120                 125             


Ser Arg Tyr Ala Ile Asp Phe Ser Gly Gly Ala Pro Lys Ile Val Ser 
    130                 135                 140                 


Lys Tyr Val Val Leu Lys Asn Asp Tyr Ile Asn Gln Leu Ile Asp Ile 
145                 150                 155                 160 


Tyr His Ile 
            


<210>  7
<211>  413
<212>  PRT
<213>  Comomonas testosteronis

<400>  7

Met Gln Glu Ser Ile Ile Gln Trp His Gly Ala Thr Asn Thr Arg Val 
1               5                   10                  15      


Pro Phe Gly Ile Tyr Thr Asp Thr Ala Asn Ala Asp Gln Glu Gln Gln 
            20                  25                  30          


Arg Ile Tyr Arg Gly Glu Val Trp Asn Tyr Leu Cys Leu Glu Ser Glu 
        35                  40                  45              


Ile Pro Gly Ala Gly Asp Phe Arg Thr Thr Phe Ala Gly Glu Thr Pro 
    50                  55                  60                  


Ile Val Val Val Arg Asp Ala Asp Gln Glu Ile Tyr Ala Phe Glu Asn 
65                  70                  75                  80  


Arg Cys Ala His Arg Gly Ala Leu Ile Ala Leu Glu Lys Ser Gly Arg 
                85                  90                  95      


Thr Asp Ser Phe Gln Cys Val Tyr His Ala Trp Ser Tyr Asn Arg Gln 
            100                 105                 110         


Gly Asp Leu Thr Gly Val Ala Phe Glu Lys Gly Val Lys Gly Gln Gly 
        115                 120                 125             


Gly Met Pro Ala Ser Phe Cys Lys Glu Glu His Gly Pro Arg Lys Leu 
    130                 135                 140                 


Arg Val Ala Val Phe Cys Gly Leu Val Phe Gly Ser Phe Ser Glu Asp 
145                 150                 155                 160 


Val Pro Ser Ile Glu Asp Tyr Leu Gly Pro Glu Ile Cys Glu Arg Ile 
                165                 170                 175     


Glu Arg Val Leu His Lys Pro Val Glu Val Ile Gly Arg Phe Thr Gln 
            180                 185                 190         


Lys Leu Pro Asn Asn Trp Lys Leu Tyr Phe Glu Asn Val Lys Asp Ser 
        195                 200                 205             


Tyr His Ala Ser Leu Leu His Met Phe Phe Thr Thr Phe Glu Leu Asn 
    210                 215                 220                 


Arg Leu Ser Gln Lys Gly Gly Val Ile Val Asp Glu Ser Gly Gly His 
225                 230                 235                 240 


His Val Ser Tyr Ser Met Ile Asp Arg Ser Ala Lys Asp Asp Ser Tyr 
                245                 250                 255     


Lys Asp Gln Ala Ile Arg Ser Asp Asn Glu Arg Tyr Arg Leu Lys Asp 
            260                 265                 270         


Pro Ser Leu Leu Glu Gly Phe Glu Glu Phe Glu Asp Gly Val Thr Leu 
        275                 280                 285             


Gln Ile Leu Ser Val Phe Pro Gly Phe Val Leu Gln Gln Ile Gln Asn 
    290                 295                 300                 


Ser Ile Ala Val Arg Gln Leu Leu Pro Lys Ser Ile Ser Ser Ser Glu 
305                 310                 315                 320 


Leu Asn Trp Thr Tyr Leu Gly Tyr Ala Asp Asp Ser Ala Glu Gln Arg 
                325                 330                 335     


Lys Val Arg Leu Lys Gln Ala Asn Leu Ile Gly Pro Ala Gly Phe Ile 
            340                 345                 350         


Ser Met Glu Asp Gly Ala Val Gly Gly Phe Val Gln Arg Gly Ile Ala 
        355                 360                 365             


Gly Ala Ala Asn Leu Asp Ala Val Ile Glu Met Gly Gly Asp His Glu 
    370                 375                 380                 


Gly Ser Ser Glu Gly Arg Ala Thr Glu Ala Ser Val Arg Gly Phe Trp 
385                 390                 395                 400 


Lys Ala Tyr Arg Lys His Met Gly Gln Glu Met Gln Ala 
                405                 410             


<210>  8
<211>  1588
<212>  PRT
<213>  S. cerevisiae

<400>  8

Met Val Gln Leu Ala Lys Val Pro Ile Leu Gly Asn Asp Ile Ile His 
1               5                   10                  15      


Val Gly Tyr Asn Ile His Asp His Leu Val Glu Thr Ile Ile Lys His 
            20                  25                  30          


Cys Pro Ser Ser Thr Tyr Val Ile Cys Asn Asp Thr Asn Leu Ser Lys 
        35                  40                  45              


Val Pro Tyr Tyr Gln Gln Leu Val Leu Glu Phe Lys Ala Ser Leu Pro 
    50                  55                  60                  


Glu Gly Ser Arg Leu Leu Thr Tyr Val Val Lys Pro Gly Glu Thr Ser 
65                  70                  75                  80  


Lys Ser Arg Glu Thr Lys Ala Gln Leu Glu Asp Tyr Leu Leu Val Glu 
                85                  90                  95      


Gly Cys Thr Arg Asp Thr Val Met Val Ala Ile Gly Gly Gly Val Ile 
            100                 105                 110         


Gly Asp Met Ile Gly Phe Val Ala Ser Thr Phe Met Arg Gly Val Arg 
        115                 120                 125             


Val Val Gln Val Pro Thr Ser Leu Leu Ala Met Val Asp Ser Ser Ile 
    130                 135                 140                 


Gly Gly Lys Thr Ala Ile Asp Thr Pro Leu Gly Lys Asn Phe Ile Gly 
145                 150                 155                 160 


Ala Phe Trp Gln Pro Lys Phe Val Leu Val Asp Ile Lys Trp Leu Glu 
                165                 170                 175     


Thr Leu Ala Lys Arg Glu Phe Ile Asn Gly Met Ala Glu Val Ile Lys 
            180                 185                 190         


Thr Ala Cys Ile Trp Asn Ala Asp Glu Phe Thr Arg Leu Glu Ser Asn 
        195                 200                 205             


Ala Ser Leu Phe Leu Asn Val Val Asn Gly Ala Lys Asn Val Lys Val 
    210                 215                 220                 


Thr Asn Gln Leu Thr Asn Glu Ile Asp Glu Ile Ser Asn Thr Asp Ile 
225                 230                 235                 240 


Glu Ala Met Leu Asp His Thr Tyr Lys Leu Val Leu Glu Ser Ile Lys 
                245                 250                 255     


Val Lys Ala Glu Val Val Ser Ser Asp Glu Arg Glu Ser Ser Leu Arg 
            260                 265                 270         


Asn Leu Leu Asn Phe Gly His Ser Ile Gly His Ala Tyr Glu Ala Ile 
        275                 280                 285             


Leu Thr Pro Gln Ala Leu His Gly Glu Cys Val Ser Ile Gly Met Val 
    290                 295                 300                 


Lys Glu Ala Glu Leu Ser Arg Tyr Phe Gly Ile Leu Ser Pro Thr Gln 
305                 310                 315                 320 


Val Ala Arg Leu Ser Lys Ile Leu Val Ala Tyr Gly Leu Pro Val Ser 
                325                 330                 335     


Pro Asp Glu Lys Trp Phe Lys Glu Leu Thr Leu His Lys Lys Thr Pro 
            340                 345                 350         


Leu Asp Ile Leu Leu Lys Lys Met Ser Ile Asp Lys Lys Asn Glu Gly 
        355                 360                 365             


Ser Lys Lys Lys Val Val Ile Leu Glu Ser Ile Gly Lys Cys Tyr Gly 
    370                 375                 380                 


Asp Ser Ala Gln Phe Val Ser Asp Glu Asp Leu Arg Phe Ile Leu Thr 
385                 390                 395                 400 


Asp Glu Thr Leu Val Tyr Pro Phe Lys Asp Ile Pro Ala Asp Gln Gln 
                405                 410                 415     


Lys Val Val Ile Pro Pro Gly Ser Lys Ser Ile Ser Asn Arg Ala Leu 
            420                 425                 430         


Ile Leu Ala Ala Leu Gly Glu Gly Gln Cys Lys Ile Lys Asn Leu Leu 
        435                 440                 445             


His Ser Asp Asp Thr Lys His Met Leu Thr Ala Val His Glu Leu Lys 
    450                 455                 460                 


Gly Ala Thr Ile Ser Trp Glu Asp Asn Gly Glu Thr Val Val Val Glu 
465                 470                 475                 480 


Gly His Gly Gly Ser Thr Leu Ser Ala Cys Ala Asp Pro Leu Tyr Leu 
                485                 490                 495     


Gly Asn Ala Gly Thr Ala Ser Arg Phe Leu Thr Ser Leu Ala Ala Leu 
            500                 505                 510         


Val Asn Ser Thr Ser Ser Gln Lys Tyr Ile Val Leu Thr Gly Asn Ala 
        515                 520                 525             


Arg Met Gln Gln Arg Pro Ile Ala Pro Leu Val Asp Ser Leu Arg Ala 
    530                 535                 540                 


Asn Gly Thr Lys Ile Glu Tyr Leu Asn Asn Glu Gly Ser Leu Pro Ile 
545                 550                 555                 560 


Lys Val Tyr Thr Asp Ser Val Phe Lys Gly Gly Arg Ile Glu Leu Ala 
                565                 570                 575     


Ala Thr Val Ser Ser Gln Tyr Val Ser Ser Ile Leu Met Cys Ala Pro 
            580                 585                 590         


Tyr Ala Glu Glu Pro Val Thr Leu Ala Leu Val Gly Gly Lys Pro Ile 
        595                 600                 605             


Ser Lys Leu Tyr Val Asp Met Thr Ile Lys Met Met Glu Lys Phe Gly 
    610                 615                 620                 


Ile Asn Val Glu Thr Ser Thr Thr Glu Pro Tyr Thr Tyr Tyr Ile Pro 
625                 630                 635                 640 


Lys Gly His Tyr Ile Asn Pro Ser Glu Tyr Val Ile Glu Ser Asp Ala 
                645                 650                 655     


Ser Ser Ala Thr Tyr Pro Leu Ala Phe Ala Ala Met Thr Gly Thr Thr 
            660                 665                 670         


Val Thr Val Pro Asn Ile Gly Phe Glu Ser Leu Gln Gly Asp Ala Arg 
        675                 680                 685             


Phe Ala Arg Asp Val Leu Lys Pro Met Gly Cys Lys Ile Thr Gln Thr 
    690                 695                 700                 


Ala Thr Ser Thr Thr Val Ser Gly Pro Pro Val Gly Thr Leu Lys Pro 
705                 710                 715                 720 


Leu Lys His Val Asp Met Glu Pro Met Thr Asp Ala Phe Leu Thr Ala 
                725                 730                 735     


Cys Val Val Ala Ala Ile Ser His Asp Ser Asp Pro Asn Ser Ala Asn 
            740                 745                 750         


Thr Thr Thr Ile Glu Gly Ile Ala Asn Gln Arg Val Lys Glu Cys Asn 
        755                 760                 765             


Arg Ile Leu Ala Met Ala Thr Glu Leu Ala Lys Phe Gly Val Lys Thr 
    770                 775                 780                 


Thr Glu Leu Pro Asp Gly Ile Gln Val His Gly Leu Asn Ser Ile Lys 
785                 790                 795                 800 


Asp Leu Lys Val Pro Ser Asp Ser Ser Gly Pro Val Gly Val Cys Thr 
                805                 810                 815     


Tyr Asp Asp His Arg Val Ala Met Ser Phe Ser Leu Leu Ala Gly Met 
            820                 825                 830         


Val Asn Ser Gln Asn Glu Arg Asp Glu Val Ala Asn Pro Val Arg Ile 
        835                 840                 845             


Leu Glu Arg His Cys Thr Gly Lys Thr Trp Pro Gly Trp Trp Asp Val 
    850                 855                 860                 


Leu His Ser Glu Leu Gly Ala Lys Leu Asp Gly Ala Glu Pro Leu Glu 
865                 870                 875                 880 


Cys Thr Ser Lys Lys Asn Ser Lys Lys Ser Val Val Ile Ile Gly Met 
                885                 890                 895     


Arg Ala Ala Gly Lys Thr Thr Ile Ser Lys Trp Cys Ala Ser Ala Leu 
            900                 905                 910         


Gly Tyr Lys Leu Val Asp Leu Asp Glu Leu Phe Glu Gln Gln His Asn 
        915                 920                 925             


Asn Gln Ser Val Lys Gln Phe Val Val Glu Asn Gly Trp Glu Lys Phe 
    930                 935                 940                 


Arg Glu Glu Glu Thr Arg Ile Phe Lys Glu Val Ile Gln Asn Tyr Gly 
945                 950                 955                 960 


Asp Asp Gly Tyr Val Phe Ser Thr Gly Gly Gly Ile Val Glu Ser Ala 
                965                 970                 975     


Glu Ser Arg Lys Ala Leu Lys Asp Phe Ala Ser Ser Gly Gly Tyr Val 
            980                 985                 990         


Leu His Leu His Arg Asp Ile Glu  Glu Thr Ile Val Phe  Leu Gln Ser 
        995                 1000                 1005             


Asp Pro  Ser Arg Pro Ala Tyr  Val Glu Glu Ile Arg  Glu Val Trp 
    1010                 1015                 1020             


Asn Arg  Arg Glu Gly Trp Tyr  Lys Glu Cys Ser Asn  Phe Ser Phe 
    1025                 1030                 1035             


Phe Ala  Pro His Cys Ser Ala  Glu Ala Glu Phe Gln  Ala Leu Arg 
    1040                 1045                 1050             


Arg Ser  Phe Ser Lys Tyr Ile  Ala Thr Ile Thr Gly  Val Arg Glu 
    1055                 1060                 1065             


Ile Glu  Ile Pro Ser Gly Arg  Ser Ala Phe Val Cys  Leu Thr Phe 
    1070                 1075                 1080             


Asp Asp  Leu Thr Glu Gln Thr  Glu Asn Leu Thr Pro  Ile Cys Tyr 
    1085                 1090                 1095             


Gly Cys  Glu Ala Val Glu Val  Arg Val Asp His Leu  Ala Asn Tyr 
    1100                 1105                 1110             


Ser Ala  Asp Phe Val Ser Lys  Gln Leu Ser Ile Leu  Arg Lys Ala 
    1115                 1120                 1125             


Thr Asp  Ser Ile Pro Ile Ile  Phe Thr Val Arg Thr  Met Lys Gln 
    1130                 1135                 1140             


Gly Gly  Asn Phe Pro Asp Glu  Glu Phe Lys Thr Leu  Arg Glu Leu 
    1145                 1150                 1155             


Tyr Asp  Ile Ala Leu Lys Asn  Gly Val Glu Phe Leu  Asp Leu Glu 
    1160                 1165                 1170             


Leu Thr  Leu Pro Thr Asp Ile  Gln Tyr Glu Val Ile  Asn Lys Arg 
    1175                 1180                 1185             


Gly Asn  Thr Lys Ile Ile Gly  Ser His His Asp Phe  Gln Gly Leu 
    1190                 1195                 1200             


Tyr Ser  Trp Asp Asp Ala Glu  Trp Glu Asn Arg Phe  Asn Gln Ala 
    1205                 1210                 1215             


Leu Thr  Leu Asp Val Asp Val  Val Lys Phe Val Gly  Thr Ala Val 
    1220                 1225                 1230             


Asn Phe  Glu Asp Asn Leu Arg  Leu Glu His Phe Arg  Asp Thr His 
    1235                 1240                 1245             


Lys Asn  Lys Pro Leu Ile Ala  Val Asn Met Thr Ser  Lys Gly Ser 
    1250                 1255                 1260             


Ile Ser  Arg Val Leu Asn Asn  Val Leu Thr Pro Val  Thr Ser Asp 
    1265                 1270                 1275             


Leu Leu  Pro Asn Ser Ala Ala  Pro Gly Gln Leu Thr  Val Ala Gln 
    1280                 1285                 1290             


Ile Asn  Lys Met Tyr Thr Ser  Met Gly Gly Ile Glu  Pro Lys Glu 
    1295                 1300                 1305             


Leu Phe  Val Val Gly Lys Pro  Ile Gly His Ser Arg  Ser Pro Ile 
    1310                 1315                 1320             


Leu His  Asn Thr Gly Tyr Glu  Ile Leu Gly Leu Pro  His Lys Phe 
    1325                 1330                 1335             


Asp Lys  Phe Glu Thr Glu Ser  Ala Gln Leu Val Lys  Glu Lys Leu 
    1340                 1345                 1350             


Leu Asp  Gly Asn Lys Asn Phe  Gly Gly Ala Ala Val  Thr Ile Pro 
    1355                 1360                 1365             


Leu Lys  Leu Asp Ile Met Gln  Tyr Met Asp Glu Leu  Thr Asp Ala 
    1370                 1375                 1380             


Ala Lys  Val Ile Gly Ala Val  Asn Thr Val Ile Pro  Leu Gly Asn 
    1385                 1390                 1395             


Lys Lys  Phe Lys Gly Asp Asn  Thr Asp Trp Leu Gly  Ile Arg Asn 
    1400                 1405                 1410             


Ala Leu  Ile Asn Asn Gly Val  Pro Glu Tyr Val Gly  His Thr Ala 
    1415                 1420                 1425             


Gly Leu  Val Ile Gly Ala Gly  Gly Thr Ser Arg Ala  Ala Leu Tyr 
    1430                 1435                 1440             


Ala Leu  His Ser Leu Gly Cys  Lys Lys Ile Phe Ile  Ile Asn Arg 
    1445                 1450                 1455             


Thr Thr  Ser Lys Leu Lys Pro  Leu Ile Glu Ser Leu  Pro Ser Glu 
    1460                 1465                 1470             


Phe Asn  Ile Ile Gly Ile Glu  Ser Thr Lys Ser Ile  Glu Glu Ile 
    1475                 1480                 1485             


Lys Glu  His Val Gly Val Ala  Val Ser Cys Val Pro  Ala Asp Lys 
    1490                 1495                 1500             


Pro Leu  Asp Asp Glu Leu Leu  Ser Lys Leu Glu Arg  Phe Leu Val 
    1505                 1510                 1515             


Lys Gly  Ala His Ala Ala Phe  Val Pro Thr Leu Leu  Glu Ala Ala 
    1520                 1525                 1530             


Tyr Lys  Pro Ser Val Thr Pro  Val Met Thr Ile Ser  Gln Asp Lys 
    1535                 1540                 1545             


Tyr Gln  Trp His Val Val Pro  Gly Ser Gln Met Leu  Val His Gln 
    1550                 1555                 1560             


Gly Val  Ala Gln Phe Glu Lys  Trp Thr Gly Phe Lys  Gly Pro Phe 
    1565                 1570                 1575             


Lys Ala  Ile Phe Asp Ala Val  Thr Lys Glu 
    1580                 1585             


<210>  9
<211>  483
<212>  PRT
<213>  Pseudomonas putida

<400>  9

Met Lys Thr Lys Leu Phe Ile Asn Asn Ala Trp Ile Asp Ser Ser Asp 
1               5                   10                  15      


Gln Gln Thr Phe Glu Arg Lys His Pro Val Ser Ser Glu Val Met Thr 
            20                  25                  30          


Glu Ser Ala Asn Ala Thr Val Thr Asp Ala Ile Lys Ala Ala Gln Ala 
        35                  40                  45              


Ala Glu Glu Ala Phe Lys Thr Trp Lys Asp Val Gly Pro Ser Glu Arg 
    50                  55                  60                  


Arg Arg Leu Leu Leu Lys Val Ala Asp Val Met Glu Ser Lys Thr Pro 
65                  70                  75                  80  


Lys Phe Ile Glu Val Met Ala Met Glu Val Gly Ala Ser Ala Leu Trp 
                85                  90                  95      


Ala Gly Phe Asn Val His Ala Ser Ala Asn Val Phe Arg Glu Ala Ala 
            100                 105                 110         


Ser Leu Ala Thr Gln Ile Gln Gly Glu Thr Ile Pro Thr Asp Lys Ala 
        115                 120                 125             


Glu Thr Leu Ser Met Thr Leu Arg Gln Pro Val Gly Pro Ile Leu Ser 
    130                 135                 140                 


Ile Val Pro Trp Asn Gly Thr Ala Val Leu Ala Ala Arg Ala Ile Ala 
145                 150                 155                 160 


Tyr Pro Leu Val Cys Gly Asn Thr Val Val Phe Lys Gly Ser Glu Phe 
                165                 170                 175     


Ser Pro Ala Thr His Ala Leu Ile Thr Gln Cys Val Gln Glu Ala Gly 
            180                 185                 190         


Leu Pro Ala Gly Val Leu Asn Tyr Leu Asn Ser Ser Pro Asp Arg Ser 
        195                 200                 205             


Pro Glu Ile Ala Asp Ala Leu Ile Ser Ala Lys Glu Ile Arg Arg Ile 
    210                 215                 220                 


Asn Phe Thr Gly Ser Thr Arg Val Gly Ser Ile Ile Ala Gln Lys Ala 
225                 230                 235                 240 


Ala Gln His Leu Lys Arg Cys Leu Leu Glu Leu Gly Gly Lys Ser Pro 
                245                 250                 255     


Leu Ile Val Leu Asp Asp Ala Asp Ile Asn Ala Ala Val Lys Ala Ala 
            260                 265                 270         


Val Phe Gly Ser Phe Leu Phe Gln Gly Gln Ile Cys Met Ser Thr Glu 
        275                 280                 285             


Arg Leu Val Val Asp Glu Lys Ile Ala Asp Glu Phe Val Ala Arg Phe 
    290                 295                 300                 


Val Glu Lys Thr Glu Arg Leu Ser Val Gly Asp Pro Cys Leu Thr Gly 
305                 310                 315                 320 


Asp Cys Ile Ile Gly Pro Met Val Ser Pro Asn Ser Gly Glu Arg Ile 
                325                 330                 335     


Asn Gly Leu Phe Lys Asp Ala Ile Asp Lys Gly Ala Lys Val Val Cys 
            340                 345                 350         


Gly Gly Met Ala Gln Gly Ala Val Met Pro Ala Thr Ile Leu Asp His 
        355                 360                 365             


Val Lys Ser Asp Met Arg Ile Tyr Asp Glu Glu Thr Phe Gly Pro Ile 
    370                 375                 380                 


Thr Val Val Ile Arg Cys Lys Gly Glu Ala Glu Ala Ile Arg Ile Ala 
385                 390                 395                 400 


Asn Asp Ser Val Tyr Gly Leu Ser Ser Gly Val Phe Gly Arg Asp Ile 
                405                 410                 415     


Asn Arg Ala Leu Arg Val Gly Met Ser Ile Glu Tyr Gly Cys Val His 
            420                 425                 430         


Ile Asn Gly Ser Thr Val Gln Asn Glu Ala Gln Ala Pro Tyr Gly Gly 
        435                 440                 445             


Thr Lys Asn Thr Gly Tyr Gly Arg Phe Asp Gly Arg Ala Val Ile Asp 
    450                 455                 460                 


Glu Phe Thr Glu Leu Lys Trp Leu Thr Ile Glu Pro Phe Glu Gln Gln 
465                 470                 475                 480 


Tyr Pro Phe 
            


<210>  10
<211>  276
<212>  PRT
<213>  Novosphingobium aromaticivorans

<400>  10

Met Ser Ala Pro Val Gly Gln Gly Ile Glu Gly Arg Pro Thr His Val 
1               5                   10                  15      


Thr Pro Glu Arg Phe Phe Gly Gln Gly Val Val Val Thr Gly Ala Ala 
            20                  25                  30          


Gln Gly Ile Gly Met Ala Val Ala His Arg Ile Ala Tyr Glu Asp Gly 
        35                  40                  45              


Asn Leu Val Leu Val Asp Arg Ser Pro Leu Val His Glu Val Ala Glu 
    50                  55                  60                  


Glu Leu Arg Lys Ala Gly Ala Gly Thr Val Asp Ser Phe Ile Ala Asp 
65                  70                  75                  80  


Leu Glu Thr Phe Glu Gly Ala Thr Asp Ala Leu Glu Phe Ala Gly Gln 
                85                  90                  95      


Lys Leu Lys Asn Leu Asp Val Val Ile Asn Asn Val Gly Gly Thr Ile 
            100                 105                 110         


Trp Ala Lys Pro Tyr Gln Glu Tyr Ser Glu Glu Glu Ile Arg Lys Glu 
        115                 120                 125             


Ile Asn Arg Ser Leu Phe Pro Thr Leu Trp Met Cys Arg Ala Ala Leu 
    130                 135                 140                 


Pro Ile Leu Ile Gly Asn Gly Gly Gly Thr Ile Val Asn Val Ser Ser 
145                 150                 155                 160 


Ile Ala Thr Gly Gly Ile Asn Arg Val Pro Tyr Ala Ala Ala Lys Gly 
                165                 170                 175     


Gly Val Asn Gly Ile Val Ser Ala Met Ala Arg Glu Ala Ala Pro His 
            180                 185                 190         


Asn Val Arg Val Val Ala Thr Ala Pro Gly Gly Thr Leu Ala Pro Glu 
        195                 200                 205             


Arg Ala Val Lys Arg Gly Pro Gly Pro Glu Gly Glu Leu Glu Glu Lys 
    210                 215                 220                 


Trp Tyr Gln Gln Ile Val Asp Gln Thr Ile Asp Ser Ser Leu Met Lys 
225                 230                 235                 240 


Arg Tyr Gly Thr Leu Glu Glu Gln Ala Ala Pro Ile Cys Phe Leu Ala 
                245                 250                 255     


Ser Glu Glu Ala Ser Tyr Ile Thr Gly Ser Val Met Pro Val Gly Gly 
            260                 265                 270         


Gly Asp Gln Gly 
        275     


