               SEQUENCE LISTING

<110> Vecchione, Carmine
      Puca, Annibale Alessandro

<120> Variant of BPIFB4 protein

<130> Vec1P1WO

<160> 7

<170> BiSSAP 1.2

<210> 1
<211> 575
<212> PRT
<213> Homo sapiens


<400> 1
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Val Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Thr Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Phe Leu Ala Ser Phe Ser Thr Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

<210> 2
<211> 1728
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1728
<223> /organism="Homo sapiens"
      /mol_type="unassigned DNA"

<400> 2
atgctgcagc aaagtgatgc tctccactcg gccctgagag aggtgccctt gggtgttggt      60

gatattccct acaatgactt ccatgtccga ggaccccccc cagtatatac caacggcaaa     120

aaacttgatg gtatttacca gtatggtcac attgagacca acgacaacac tgctcagctg     180

gggggcaaat accgatatgg tgagatcctt gagtccgagg gaagcatcag ggacctccga     240

aacagtggct atcgcagtgc cgagaatgca tatggaggcc acaggggcct cgggcgatac     300

agggcagcac ctgtgggcag gcttcaccgg cgagagctgc agcctggaga aatcccacct     360

ggagttgcca ctggggcggt gggcccaggt ggtttgctgg gcactggagg catgctggca     420

gctgatggca tcctcgcagg ccaaggtggc ctgctcggcg gaggtggtct ccttggtgat     480

ggaggacttc ttggaggagg gggtgtcctg ggcgtgctcg gcgagggtgg catcctcagc     540

actgtgcaag gcatcacggg gctgcgtatc gtggagctga ccctccctcg ggtgtccgtg     600

cggctcctgc ccggcgtggg tgtctacctg agcttgtaca cccgtgtggc catcaacggg     660

aagagtctta ttggcttcct ggacgtcgca gtagaagtga acatcacagc caaggtccgg     720

ctgaccatgg accgcacggg ttatcctcgg ctggtcattg agcgatgtga caccctccta     780

gggggcatca aagtcaagct gctgcgaggg cttctcccca atctcgtgga caatttagtg     840

acccgagtcc tggccgacgt cctccctgac ttgctctgcc ccatcgtgga tgtggtgctg     900

ggtcttgtca atgaccagct gggcctcgtg gattctctga ttcctctggg gatattggga     960

agtgtccagt acaccttctc cagcctcccg cttgtgaccg gggaattcct ggagctggac    1020

ctcaacacgc tggttgggga ggctggagga ggactcatcg actacccatt ggggtggcca    1080

gctgtgtctc ccaagccgat gccagagctg cctcccatgg gtgacaacac caagtcccag    1140

ctggccatgt ctgccaactt cctgggctca gtgctgactc tactgcagaa gcagcatgct    1200

ctagacctgg atatcaccaa tggcatgttt gaagagcttc ctccacttac cacagccaca    1260

ctgggagccc tgatccccaa ggtgttccag cagtaccccg agtcctgccc acttatcatc    1320

aggatccagg tgctgaaccc accatctgtg atgctgcaga aggacaaagc gctggtgaag    1380

gtgttggcca ctgccgaggt catggtctcc cagcccaaag acctggagac taccatctgc    1440

ctcattgacg tggacacaga attcttggcc tcattttcca cagaaggaga taagctcatg    1500

attgatgcca agctggagaa gaccagcctc aacctcagaa cctcaaacgt gggcaacttt    1560

gatattggcc tcatggaggt gctggtggag aagatttttg acctggcatt catgcccgca    1620

atgaacgctg tgctgggttc tggcgtccct ctccccaaaa tcctcaacat cgactttagc    1680

aatgcagaca ttgacgtgtt ggaggacctt ttggtgctga gcgcatga                 1728


<210> 3
<211> 575
<212> PRT
<213> Homo sapiens


<400> 3
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Ile Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Asn Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Phe Leu Ala Ser Phe Ser Thr Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

<210> 4
<211> 575
<212> PRT
<213> Homo sapiens


<400> 4
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Val Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Asn Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Phe Leu Ala Ser Phe Ser Thr Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

<210> 5
<211> 575
<212> PRT
<213> Homo sapiens


<400> 5
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Ile Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Thr Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Phe Leu Ala Ser Phe Ser Thr Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

<210> 6
<211> 575
<212> PRT
<213> Homo sapiens


<400> 6
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Val Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Thr Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Leu Leu Ala Ser Phe Ser Ile Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

<210> 7
<211> 575
<212> PRT
<213> Homo sapiens


<400> 7
Met Leu Gln Gln Ser Asp Ala Leu His Ser Ala Leu Arg Glu Val Pro 
1               5                   10                  15      
Leu Gly Val Gly Asp Ile Pro Tyr Asn Asp Phe His Val Arg Gly Pro 
            20                  25                  30          
Pro Pro Val Tyr Thr Asn Gly Lys Lys Leu Asp Gly Ile Tyr Gln Tyr 
        35                  40                  45              
Gly His Ile Glu Thr Asn Asp Asn Thr Ala Gln Leu Gly Gly Lys Tyr 
    50                  55                  60                  
Arg Tyr Gly Glu Ile Leu Glu Ser Glu Gly Ser Ile Arg Asp Leu Arg 
65                  70                  75                  80  
Asn Ser Gly Tyr Arg Ser Ala Glu Asn Ala Tyr Gly Gly His Arg Gly 
                85                  90                  95      
Leu Gly Arg Tyr Arg Ala Ala Pro Val Gly Arg Leu His Arg Arg Glu 
            100                 105                 110         
Leu Gln Pro Gly Glu Ile Pro Pro Gly Val Ala Thr Gly Ala Val Gly 
        115                 120                 125             
Pro Gly Gly Leu Leu Gly Thr Gly Gly Met Leu Ala Ala Asp Gly Ile 
    130                 135                 140                 
Leu Ala Gly Gln Gly Gly Leu Leu Gly Gly Gly Gly Leu Leu Gly Asp 
145                 150                 155                 160 
Gly Gly Leu Leu Gly Gly Gly Gly Val Leu Gly Val Leu Gly Glu Gly 
                165                 170                 175     
Gly Ile Leu Ser Thr Val Gln Gly Ile Thr Gly Leu Arg Ile Val Glu 
            180                 185                 190         
Leu Thr Leu Pro Arg Val Ser Val Arg Leu Leu Pro Gly Val Gly Val 
        195                 200                 205             
Tyr Leu Ser Leu Tyr Thr Arg Val Ala Ile Asn Gly Lys Ser Leu Ile 
    210                 215                 220                 
Gly Phe Leu Asp Ile Ala Val Glu Val Asn Ile Thr Ala Lys Val Arg 
225                 230                 235                 240 
Leu Thr Met Asp Arg Thr Gly Tyr Pro Arg Leu Val Ile Glu Arg Cys 
                245                 250                 255     
Asp Thr Leu Leu Gly Gly Ile Lys Val Lys Leu Leu Arg Gly Leu Leu 
            260                 265                 270         
Pro Asn Leu Val Asp Asn Leu Val Asn Arg Val Leu Ala Asp Val Leu 
        275                 280                 285             
Pro Asp Leu Leu Cys Pro Ile Val Asp Val Val Leu Gly Leu Val Asn 
    290                 295                 300                 
Asp Gln Leu Gly Leu Val Asp Ser Leu Ile Pro Leu Gly Ile Leu Gly 
305                 310                 315                 320 
Ser Val Gln Tyr Thr Phe Ser Ser Leu Pro Leu Val Thr Gly Glu Phe 
                325                 330                 335     
Leu Glu Leu Asp Leu Asn Thr Leu Val Gly Glu Ala Gly Gly Gly Leu 
            340                 345                 350         
Ile Asp Tyr Pro Leu Gly Trp Pro Ala Val Ser Pro Lys Pro Met Pro 
        355                 360                 365             
Glu Leu Pro Pro Met Gly Asp Asn Thr Lys Ser Gln Leu Ala Met Ser 
    370                 375                 380                 
Ala Asn Phe Leu Gly Ser Val Leu Thr Leu Leu Gln Lys Gln His Ala 
385                 390                 395                 400 
Leu Asp Leu Asp Ile Thr Asn Gly Met Phe Glu Glu Leu Pro Pro Leu 
                405                 410                 415     
Thr Thr Ala Thr Leu Gly Ala Leu Ile Pro Lys Val Phe Gln Gln Tyr 
            420                 425                 430         
Pro Glu Ser Cys Pro Leu Ile Ile Arg Ile Gln Val Leu Asn Pro Pro 
        435                 440                 445             
Ser Val Met Leu Gln Lys Asp Lys Ala Leu Val Lys Val Leu Ala Thr 
    450                 455                 460                 
Ala Glu Val Met Val Ser Gln Pro Lys Asp Leu Glu Thr Thr Ile Cys 
465                 470                 475                 480 
Leu Ile Asp Val Asp Thr Glu Leu Leu Ala Ser Phe Ser Ile Glu Gly 
                485                 490                 495     
Asp Lys Leu Met Ile Asp Ala Lys Leu Glu Lys Thr Ser Leu Asn Leu 
            500                 505                 510         
Arg Thr Ser Asn Val Gly Asn Phe Asp Ile Gly Leu Met Glu Val Leu 
        515                 520                 525             
Val Glu Lys Ile Phe Asp Leu Ala Phe Met Pro Ala Met Asn Ala Val 
    530                 535                 540                 
Leu Gly Ser Gly Val Pro Leu Pro Lys Ile Leu Asn Ile Asp Phe Ser 
545                 550                 555                 560 
Asn Ala Asp Ile Asp Val Leu Glu Asp Leu Leu Val Leu Ser Ala 
                565                 570                 575 

