SEQUENCE LISTING

<110>   Novartis AG

<120>   Novel mucinase for use in therapy or prophylaxis

<130>   P062929WO

<141>   2013-12-19

<160>   70

<170>   SeqWin2010, version 1.0

<210>   1
<211>   1526
<212>   PRT
<213>   Escherichia coli

<400>   1
Met Ser Leu Ala Leu Leu Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser 
1               5                   10                  15      

Leu Leu Ala Ala Ile Leu Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly 
            20                  25                  30          

Gly Gly Ser Gly Ser Ser Ser Asp Thr Pro Ser Val Asp Ser Gly Ser 
        35                  40                  45              

Gly Thr Leu Pro Glu Val Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro 
    50                  55                  60                  

Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro 
65                  70                  75                  80  

Asp Pro Glu Pro Thr Pro Glu Pro Glu Pro Glu Pro Val Pro Thr Lys 
                85                  90                  95      

Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala Thr 
            100                 105                 110         

Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr 
        115                 120                 125             

Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln 
    130                 135                 140                 

Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe Ser 
145                 150                 155                 160 

Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn 
                165                 170                 175     

Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu 
            180                 185                 190         

Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe Glu 
        195                 200                 205             

Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu 
    210                 215                 220                 

Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser 
225                 230                 235                 240 

Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys Pro 
                245                 250                 255     

Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln 
            260                 265                 270         

Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp Ser 
        275                 280                 285             

Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg 
    290                 295                 300                 

Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr 
305                 310                 315                 320 

Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn 
                325                 330                 335     

Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala 
            340                 345                 350         

Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn 
        355                 360                 365             

Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro 
    370                 375                 380                 

Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr 
385                 390                 395                 400 

Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile Glu 
                405                 410                 415     

Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala 
            420                 425                 430         

Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg 
        435                 440                 445             

Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly 
    450                 455                 460                 

Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val Phe His Asp 
465                 470                 475                 480 

Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val 
                485                 490                 495     

Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala Arg Asn Asp 
            500                 505                 510         

Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn 
        515                 520                 525             

Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu Asn 
    530                 535                 540                 

Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly 
545                 550                 555                 560 

Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn 
                565                 570                 575     

Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn 
            580                 585                 590         

Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys His 
        595                 600                 605             

Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro 
    610                 615                 620                 

Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val Tyr 
625                 630                 635                 640 

Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe 
                645                 650                 655     

His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly 
            660                 665                 670         

Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu 
        675                 680                 685             

Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala 
    690                 695                 700                 

Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile 
705                 710                 715                 720 

Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met 
                725                 730                 735     

Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu Asp 
            740                 745                 750         

Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp 
        755                 760                 765             

Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly Ile 
    770                 775                 780                 

Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln Pro Pro Tyr 
785                 790                 795                 800 

Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr Gln Gln Asp 
                805                 810                 815     

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu 
            820                 825                 830         

Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala 
        835                 840                 845             

Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe 
    850                 855                 860                 

Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr 
865                 870                 875                 880 

Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro Val Thr 
                885                 890                 895     

Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp 
            900                 905                 910         

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
        915                 920                 925             

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly Ser Lys Gly 
    930                 935                 940                 

Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
945                 950                 955                 960 

Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu 
                965                 970                 975     

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
            980                 985                 990         

Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys 
        995                 1000                1005            

Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala 
    1010                1015                1020                

Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu 
1025                1030                1035                1040

Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val 
                1045                1050                1055    

Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly Glu Ser Val 
            1060                1065                1070        

Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly 
        1075                1080                1085            

Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Asp Val Thr 
    1090                1095                1100                

Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu Ala 
1105                1110                1115                1120

Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro 
                1125                1130                1135    

Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly Glu Val Thr 
            1140                1145                1150        

Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys 
        1155                1160                1165            

Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala Pro 
    1170                1175                1180                

Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser Pro Ala Pro 
1185                1190                1195                1200

Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys 
                1205                1210                1215    

Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala Lys 
            1220                1225                1230        

Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn 
        1235                1240                1245            

Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly 
    1250                1255                1260                

His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala 
1265                1270                1275                1280

His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr 
                1285                1290                1295    

Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val 
            1300                1305                1310        

Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr Glu 
        1315                1320                1325            

Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly 
    1330                1335                1340                

Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu 
1345                1350                1355                1360

Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg 
                1365                1370                1375    

Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp 
            1380                1385                1390        

Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp 
        1395                1400                1405            

Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys 
    1410                1415                1420                

Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr 
1425                1430                1435                1440

Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala 
                1445                1450                1455    

Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn 
            1460                1465                1470        

Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe 
        1475                1480                1485            

Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys 
    1490                1495                1500                

Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr Glu 
1505                1510                1515                1520

His Lys Met Ser Ala Glu 
                1525    

<210>   2
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   2
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly 
        115                 120                 125             

Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala 
        275                 280                 285             

Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn 
    290                 295                 300                 

Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln 
385                 390                 395                 400 

Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr 
            580                 585                 590         

Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln 
625                 630                 635                 640 

Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly 
                645                 650                 655     

Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu 
            660                 665                 670         

Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser 
        675                 680                 685             

Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr 
785                 790                 795                 800 

Gly Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
            820                 825                 830         

Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu 
        835                 840                 845             

Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
865                 870                 875                 880 

Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
945                 950                 955                 960 

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
            980                 985                 990         

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
                1205                1210                1215    

Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   3
<211>   4581
<212>   DNA
<213>   Escherichia coli

<400>   3
ttgtcacttg cgttattaat gaataagaaa tttaaatata agaaatcgct tttagcggct  60
attttaagcg caaccctgtt agccggttgt gatggtggtg gttcaggatc gtcctccgat  120
acgccgtctg tagattctgg atcagggact ttgccggaag tgaaacccga tccaacacca  180
accccggagc cgacacctga gccgacgccg gacccagaac ctacgccgga tccaacacct  240
gatcctgagc cgacaccaga accggagcca gaacctgttc ctacgaaaac gggttatctg  300
accctgggcg gaagccagcg ggtaactggt gctacctgta atggtgaatc cagcgatggc  360
tttaccttta cgccaggcaa taccgtgagt tgtgtggtgg gcagtacgac cattgcaaca  420
ttcaacaccc agtcagaagc tgcgcgtagc ctgcgtgcgg ttgacaaagt gtcgtttagc  480
ctggaggacg cgcaggagct ggcgaattct gaaaataaga aaaccaacgc catctctctg  540
gtgacgtcca gcgacagttg ccccgcagat gcagaacagc tttgtcttac tttctcgtca  600
gtggttgatc gcgcgcgatt tgaaaaactg tataagcaaa ttgatctggc aacagacaat  660
ttcagcaagc tggtcaatga agaggtggaa aacaatgctg cgactgataa agcgccgtcc  720
acccatacct caacggtagt gccagtcacg acagagggaa caaaaccgga tctgaacgcg  780
tccttcgtgt cggctaacgc ggaacagttt tatcagtatc aacccactga aatcattctt  840
tccgaaggcc aactggtgga tagcctgggg aacggtgttg ctggcgttga ctactacacc  900
aattcaggcc gtggcgtaac tgacgaaaac ggtaaatttt cctttagctg gggcgaaacc  960
atctcctttg gtatcgatac ctttgaactg ggctcagtac gtggcaataa gtcgaccatt  1020
gcgctgactg aattgggtga tgaagttcgc ggggcaaata tcgatcagct cattcatcgt  1080
tattcgacga ctggtcaaaa taatactcgt gttgttccgg acgatgtacg caaggtcttt  1140
gccgaatatc ccaacgtgat caacgagata atcaatcttt cgttatccaa cggtgcgacg  1200
ctggatgaag gcgatcaaaa cgttgtgctg cctaacgaat ttatcgagca gtttaagacg  1260
ggtcaggcca aagagatcga taccgcgatt tgtgcgaaaa ccgacggttg taacgaggct  1320
cgctggttct cgctgacaac gcgcaatgtt aatgacggcc agattcaggg cgttattaac  1380
aagctgtggg gcgtggatac gaactatcag tctgtcagca agttccacgt cttccatgac  1440
tctaccaact tctatggcag caccggtaac gcgcgcggtc aggcggtggt aaatatctcc  1500
aactcggcat tcccgattct gatggcgcgt aatgataaaa actactggct ggcgtttggc  1560
gaaaaacgcg cctgggataa aaatgagctg gcgtacatta cggaagcgcc ttccattgtg  1620
cagccagaga acgttacgcg cgatactgcg actttcaacc tgccgtttat ttcgctgggg  1680
caagtcggtg aaggcaaact gatggttatc ggtaacccgc actacaacag catcctgcgt  1740
tgcccgaacg gttacagttg gggcggtggt gttaatagta aaggtgagtg tacgctcagc  1800
ggtgattctg atgacatgaa gcactttatg cagaacgtac tgcgctactt gtcaaatgac  1860
atctggcagc caaataccaa gagcatcatg actgtcggca ccaacctgga gaacgtttat  1920
ttcaaaaaag cgggccaggt attgggaaat agtgcaccat ttgctttcca tgaggatttc  1980
actggtatca cggttaaaca gttgaccagc tatggcgatc tgaatccgga agagattccg  2040
ttgctgatcc tcaacggctt tgaatatgtg actcagtggt ctggcgatcc ctatgctgtg  2100
cctctgcgtg cagataccag caaaccgaag ctgactcagc aggatgtgac cgatctgatc  2160
gcttatctga acaaaggtgg ctcggtgctg atcatggaaa acgtgatgag caatcttaag  2220
gaagagagcg cgtccagttt tgtgcgtctg ctggatgccg cgggtctgtc aatggctctg  2280
aacaaatcgg tggtgaacaa cgatccgcaa gggtatccgg atcgcgttcg tcagcgtcgc  2340
gcgactggca tttgggttta tgaacgttat cctgctgcag acggcgcgca accgccgtac  2400
accatcgacc caaatacagg ggaagtgacc tggaaatacc agcaagacaa caagcctgat  2460
gacaagccga aactggaagt tgcgagctgg caggaggaag ttgagggcaa acaggtaacg  2520
cgttatgcct ttattgatga agcggaatac acaacagaag aatctctgga agcggcaaag  2580
gcaaaaatct ttgagaagtt tcctgggtta caggagtgta aggactcgac ttaccattac  2640
gagattaact gtttggagcg ccgcccaggc acggatgttc cggtaacagg tggcatgtat  2700
gttccgcgct atacgcaact gaatcttgac gccgacaccg cgaaagcgat ggtgcaggcg  2760
gcggatttag gcaccaacat tcagcgcctg tatcagcatg agctttattt ccgtaccaaa  2820
ggcagtaaag gtgagcgtct gaacagtgtt gatctggaac gtctgtacca gaacatgtcg  2880
gtctggctgt ggaacgatac gaaatatcgt tacgaagagg gcaaggaaga tgagctgggc  2940
tttaaaacgt tcaccgagtt cctgaactgc tacgccaatg atgcctatgc aggcggcacc  3000
aagtgctccg cagatctgaa aaaatcgctg gtcgataaca acatgatcta cggtgacggt  3060
agcagcaaag cgggcatgat gaacccaagc tatccgctca actatatgga aaaaccgctg  3120
acgcgtctga tgctgggccg ttcctggtgg gatctgaaca ttaaggttga tgtggagaag  3180
tacccaggat ccgtatcggc aaagggtgag agcgttacgg aaaacatcag cctgtactcg  3240
aatccgacca aatggtttgc gggtaacatg cagtcaaccg gcctgtgggc accggcccag  3300
caggacgtca ccattaagtc ttcggcgtca gtcccagtga ctgttaccgt ggcgctggct  3360
gacgacctga ctggacgtga gaagcatgaa gttgcgctga accgtccgcc aagagtgact  3420
aaaacgtata ctctggaggc taacggtgaa gtgaccttca aggtgcctta tggtggtctg  3480
atttatatca agggcgacag taaggatgat gtttctgcta acttcacctt taccggtgta  3540
gtaaaagcgc cgttctataa agacggcgaa tggaaaaacg atctggactc accggcgccg  3600
ctgggcgagc tggagtctgc gtcgttcgtc tataccacgc cgaagaagaa ccttgaggcc  3660
agcaatttca ctggtggtgt agcagaattc gctaaagatc tggatacctt tgccagctcg  3720
atgaatgact tctacggtcg taatgatgaa gacggtaagc accggatgtt tacctataaa  3780
aacttgacgg ggcacaagca tcgtttcacc aacgatgtgc agatctccat cggtgatgcg  3840
cactcgggtt atccggtaat gaacagcagc ttctcgacga acagcaccac gctgccgacg  3900
acgccgctga acgactggct gatttggcac gaagtcggtc ataacgctgc agaaacaccg  3960
ctgaacgtac cgggtgcaac tgaagtggcg aacaacgtgc tggcgctgta catgcaggat  4020
cgctatctcg gtaagatgaa ccgtgtcgct gacgacatta ccgtcgcgcc ggaatatctg  4080
gacgagagca acggtcaggc ctgggcgcgc ggcggtgcgg gtgaccgtct gctgatgtac  4140
gcacagttga aggagtgggc agaggaaaac tttgatatca aacagtggta tccagatggt  4200
gagctgccta agttctacag cgatcgtaaa gggatgaagg gctggaacct gttccagttg  4260
atgcaccgta aagcgcgcgg cgatgatgtt ggtaacagca cctttggtgg caagaattac  4320
tgtgctgaat ccaatggtaa cgctgccgac acgctgatgc tgtgtgcatc ctgggtcgct  4380
caggcggatc tttcggaatt ctttaagaaa tggaatccgg gtgcaagtgc ttaccagttg  4440
ccgggagcaa cggagatgag tttccagggc ggtgtgagct cttcggctta cagcacgctg  4500
gcgtcactca agctgccgaa accggaaaaa gggccggaaa ccattaacaa ggttaccgag  4560
cataagatgt ctgccgagta a                                            4581

<210>   4
<211>   1521
<212>   PRT
<213>   Escherichia coli

<400>   4
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
    130                 135                 140                 

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
145                 150                 155                 160 

Glu Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val 
                165                 170                 175     

Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr 
            180                 185                 190         

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
        195                 200                 205             

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
    210                 215                 220                 

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
225                 230                 235                 240 

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
                245                 250                 255     

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
            260                 265                 270         

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val 
        275                 280                 285             

Val Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu 
    290                 295                 300                 

Asn Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
305                 310                 315                 320 

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
                325                 330                 335     

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
            340                 345                 350         

Ile His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro 
        355                 360                 365             

Asp Val Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
    370                 375                 380                 

Ile Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp 
385                 390                 395                 400 

Gln Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly 
                405                 410                 415     

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys 
            420                 425                 430         

Asn Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Glu Gly 
        435                 440                 445             

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr 
    450                 455                 460                 

Lys Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
465                 470                 475                 480 

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
                485                 490                 495     

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
            500                 505                 510         

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
        515                 520                 525             

Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr 
    530                 535                 540                 

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
545                 550                 555                 560 

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
                565                 570                 575     

Pro Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys 
            580                 585                 590         

Thr Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val 
        595                 600                 605             

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
    610                 615                 620                 

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
625                 630                 635                 640 

Gln Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala 
                645                 650                 655     

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
            660                 665                 670         

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
        675                 680                 685             

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
    690                 695                 700                 

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
705                 710                 715                 720 

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
                725                 730                 735     

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
            740                 745                 750         

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
        755                 760                 765             

Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
    770                 775                 780                 

Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr 
785                 790                 795                 800 

Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln 
            820                 825                 830         

Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp 
        835                 840                 845             

Ser Leu Lys Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Lys Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu 
865                 870                 875                 880 

Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys 
945                 950                 955                 960 

Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly 
            980                 985                 990         

Gly Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Ser Ala 
    1090                1095                1100                

Ser Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys 
                1125                1130                1135    

Thr Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Gln Asn Glu Ser Ala 
        1155                1160                1165            

Glu Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Ala Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser 
                1205                1210                1215    

Asn Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe 
            1220                1225                1230        

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys 
        1235                1240                1245            

His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe 
    1250                1255                1260                

Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
1265                1270                1275                1280

Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr 
                1285                1290                1295    

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala 
            1300                1305                1310        

Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
        1315                1320                1325            

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
    1330                1335                1340                

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly 
1345                1350                1355                1360

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
                1365                1370                1375    

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr 
            1380                1385                1390        

Pro Glu Gly Asp Leu Pro Lys Phe Tyr Ser Asp Arg Glu Gly Met Lys 
        1395                1400                1405            

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu 
    1410                1415                1420                

Val Gly Lys Thr Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn 
1425                1430                1435                1440

Gly Asn Ala Ala Asp Lys Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
                1445                1450                1455    

Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
            1460                1465                1470        

Tyr Gln Leu Pro Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser 
        1475                1480                1485            

Gln Ser Ala Tyr Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln 
    1490                1495                1500                

Gln Gly Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala 
1505                1510                1515                1520

Glu 
    

<210>   5
<211>   1521
<212>   PRT
<213>   Escherichia coli

<400>   5
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
    130                 135                 140                 

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
145                 150                 155                 160 

Glu Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val 
                165                 170                 175     

Thr Ser Ser Asn Ser Cys Pro Ala Asp Thr Glu Gln Val Cys Leu Thr 
            180                 185                 190         

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
        195                 200                 205             

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
    210                 215                 220                 

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
225                 230                 235                 240 

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
                245                 250                 255     

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
            260                 265                 270         

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val 
        275                 280                 285             

Val Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu 
    290                 295                 300                 

Asn Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
305                 310                 315                 320 

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
                325                 330                 335     

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
            340                 345                 350         

Ile His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro 
        355                 360                 365             

Asp Val Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
    370                 375                 380                 

Ile Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp 
385                 390                 395                 400 

Gln Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly 
                405                 410                 415     

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys 
            420                 425                 430         

Asn Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Asp Gly 
        435                 440                 445             

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
    450                 455                 460                 

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
465                 470                 475                 480 

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
                485                 490                 495     

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
            500                 505                 510         

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
        515                 520                 525             

Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr 
    530                 535                 540                 

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
545                 550                 555                 560 

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
                565                 570                 575     

Pro Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys 
            580                 585                 590         

Thr Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val 
        595                 600                 605             

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
    610                 615                 620                 

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
625                 630                 635                 640 

Gln Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala 
                645                 650                 655     

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
            660                 665                 670         

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
        675                 680                 685             

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
    690                 695                 700                 

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
705                 710                 715                 720 

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
                725                 730                 735     

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
            740                 745                 750         

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
        755                 760                 765             

Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
    770                 775                 780                 

Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr 
785                 790                 795                 800 

Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln 
            820                 825                 830         

Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp 
        835                 840                 845             

Ser Leu Lys Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
    850                 855                 860                 

Lys Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu 
865                 870                 875                 880 

Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys 
945                 950                 955                 960 

Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly 
            980                 985                 990         

Gly Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Thr Ala 
    1090                1095                1100                

Ser Val Ala Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys 
                1125                1130                1135    

Thr Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Gln Asn Glu Ser Ala 
        1155                1160                1165            

Glu Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Ala Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser 
                1205                1210                1215    

Asn Tyr Lys Gly Gly Gln Glu Gln Phe Ala Glu Glu Leu Asp Thr Phe 
            1220                1225                1230        

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys 
        1235                1240                1245            

His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe 
    1250                1255                1260                

Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
1265                1270                1275                1280

Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr 
                1285                1290                1295    

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Ala Gly His Asn Ala Ala 
            1300                1305                1310        

Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
        1315                1320                1325            

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
    1330                1335                1340                

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn 
1345                1350                1355                1360

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
                1365                1370                1375    

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Thr Lys Trp Tyr 
            1380                1385                1390        

Pro Glu Gly Asn Leu Pro Lys Phe Tyr Ser Glu Arg Glu Gly Met Lys 
        1395                1400                1405            

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu 
    1410                1415                1420                

Val Gly Lys Thr Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn 
1425                1430                1435                1440

Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
                1445                1450                1455    

Thr Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
            1460                1465                1470        

Tyr Gln Leu Pro Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser 
        1475                1480                1485            

Gln Ser Ala Tyr Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln 
    1490                1495                1500                

Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro Ala 
1505                1510                1515                1520

Glu 
    

<210>   6
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   6
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
        275                 280                 285             

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
    290                 295                 300                 

Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln 
385                 390                 395                 400 

Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
            580                 585                 590         

Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asp Asp Lys Trp Lys Pro Asp Ala Lys Ala Ser Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
625                 630                 635                 640 

Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala Gly 
                645                 650                 655     

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
            660                 665                 670         

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
        675                 680                 685             

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn 
        755                 760                 765             

Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly 
785                 790                 795                 800 

Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro 
                805                 810                 815     

Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu 
            820                 825                 830         

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser 
        835                 840                 845             

Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu Lys 
    850                 855                 860                 

Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
865                 870                 875                 880 

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
                885                 890                 895     

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
            900                 905                 910         

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
        915                 920                 925             

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
    930                 935                 940                 

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
945                 950                 955                 960 

Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys Thr 
                965                 970                 975     

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
            980                 985                 990         

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
        995                 1000                1005            

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
    1010                1015                1020                

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
1025                1030                1035                1040

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
                1045                1050                1055    

Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu Tyr 
            1060                1065                1070        

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
        1075                1080                1085            

Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val 
    1090                1095                1100                

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
1105                1110                1115                1120

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
                1125                1130                1135    

Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly 
            1140                1145                1150        

Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe 
        1155                1160                1165            

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp 
    1170                1175                1180                

Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp 
1185                1190                1195                1200

Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
                1205                1210                1215    

Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser 
            1220                1225                1230        

Ser Met Asn Asp Phe His Gly Arg Asp Ser Glu Asp Gly Lys His Arg 
        1235                1240                1245            

Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Thr Asn 
    1250                1255                1260                

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
1265                1270                1275                1280

Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
                1285                1290                1295    

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
            1300                1305                1310        

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
        1315                1320                1325            

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
    1330                1335                1340                

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn Gln Ala 
1345                1350                1355                1360

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
                1365                1370                1375    

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp 
            1380                1385                1390        

Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
    1410                1415                1420                

Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
        1475                1480                1485            

Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   7
<211>   1522
<212>   PRT
<213>   Escherichia coli

<400>   7
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser 
            100                 105                 110         

Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala 
        115                 120                 125             

Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala 
    130                 135                 140                 

Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala 
145                 150                 155                 160 

Gln Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu 
                165                 170                 175     

Val Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu 
            180                 185                 190         

Glu Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys 
        195                 200                 205             

Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu 
    210                 215                 220                 

Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser 
225                 230                 235                 240 

Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala 
                245                 250                 255     

Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser 
            260                 265                 270         

Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly 
        275                 280                 285             

Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly 
    290                 295                 300                 

Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly 
305                 310                 315                 320 

Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile 
                325                 330                 335     

Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln 
            340                 345                 350         

Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val 
        355                 360                 365             

Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn 
    370                 375                 380                 

Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly 
385                 390                 395                 400 

Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr 
                405                 410                 415     

Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly 
            420                 425                 430         

Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp 
        435                 440                 445             

Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn 
    450                 455                 460                 

Tyr Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe 
465                 470                 475                 480 

Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser 
                485                 490                 495     

Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp 
            500                 505                 510         

Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr 
        515                 520                 525             

Ile Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp 
    530                 535                 540                 

Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu 
545                 550                 555                 560 

Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg 
                565                 570                 575     

Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln 
            580                 585                 590         

Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn 
        595                 600                 605             

Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala 
    610                 615                 620                 

Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His 
625                 630                 635                 640 

Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe 
                645                 650                 655     

Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro 
            660                 665                 670         

Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln 
        675                 680                 685             

Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys 
    690                 695                 700                 

Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn 
705                 710                 715                 720 

Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys 
                725                 730                 735     

Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu 
            740                 745                 750         

Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr 
        755                 760                 765             

Pro Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu 
    770                 775                 780                 

Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys 
785                 790                 795                 800 

Thr Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys 
            820                 825                 830         

Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu 
        835                 840                 845             

Asp Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly 
    850                 855                 860                 

Leu Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu 
865                 870                 875                 880 

Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Cys 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Asp Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala 
            980                 985                 990         

Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn 
        995                 1000                1005            

Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala 
    1090                1095                1100                

Asn Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys 
                1125                1130                1135    

Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala 
        1155                1160                1165            

Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser 
                1205                1210                1215    

Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe 
            1220                1225                1230        

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys 
        1235                1240                1245            

His Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe 
    1250                1255                1260                

Ala Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
1265                1270                1275                1280

Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr 
                1285                1290                1295    

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala 
            1300                1305                1310        

Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
        1315                1320                1325            

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
    1330                1335                1340                

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly 
1345                1350                1355                1360

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
                1365                1370                1375    

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr 
            1380                1385                1390        

Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met 
        1395                1400                1405            

Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp 
    1410                1415                1420                

Glu Val Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser 
1425                1430                1435                1440

Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala 
                1445                1450                1455    

Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn 
            1460                1465                1470        

Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val 
        1475                1480                1485            

Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro 
    1490                1495                1500                

Glu Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser 
1505                1510                1515                1520

Val Glu 
        

<210>   8
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   8
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser 
            100                 105                 110         

Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala 
        115                 120                 125             

Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala 
    130                 135                 140                 

Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala 
145                 150                 155                 160 

Gln Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu 
                165                 170                 175     

Val Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu 
            180                 185                 190         

Glu Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys 
        195                 200                 205             

Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu 
    210                 215                 220                 

Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser 
225                 230                 235                 240 

Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala 
                245                 250                 255     

Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser 
            260                 265                 270         

Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly 
        275                 280                 285             

Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly 
    290                 295                 300                 

Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly 
305                 310                 315                 320 

Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile 
                325                 330                 335     

Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln 
            340                 345                 350         

Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val 
        355                 360                 365             

Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn 
    370                 375                 380                 

Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly 
385                 390                 395                 400 

Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr 
                405                 410                 415     

Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly 
            420                 425                 430         

Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp 
        435                 440                 445             

Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn 
    450                 455                 460                 

Tyr Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe 
465                 470                 475                 480 

Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser 
                485                 490                 495     

Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp 
            500                 505                 510         

Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Asp Leu Ala Tyr 
        515                 520                 525             

Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu 
    530                 535                 540                 

Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp 
545                 550                 555                 560 

Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg 
                565                 570                 575     

Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln 
            580                 585                 590         

Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn 
        595                 600                 605             

Val Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser 
    610                 615                 620                 

Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His 
625                 630                 635                 640 

Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Lys Asp Phe 
                645                 650                 655     

Thr Gly Ile Thr Val Lys Pro Met Thr Ser Tyr Gly Asn Leu Asn Pro 
            660                 665                 670         

Asp Glu Val Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln 
        675                 680                 685             

Trp Gly Ser Asp Pro Tyr Ser Ile Pro Leu Arg Ala Asp Thr Ser Lys 
    690                 695                 700                 

Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn 
705                 710                 715                 720 

Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys 
                725                 730                 735     

Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu 
            740                 745                 750         

Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr 
        755                 760                 765             

Pro Asp Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu 
    770                 775                 780                 

Arg Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr 
785                 790                 795                 800 

Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys 
            820                 825                 830         

Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro 
        835                 840                 845             

Glu Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly 
    850                 855                 860                 

Leu Glu Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu 
865                 870                 875                 880 

Glu Tyr Arg Pro Gly Ser Gly Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Gln Tyr Thr Gln Leu Asp Leu Gly Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Leu Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Glu Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val 
            980                 985                 990         

Gly Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys 
        995                 1000                1005            

Met Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn 
                1205                1210                1215    

Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Ser Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Ala 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro 
            1380                1385                1390        

Glu Gly Glu Leu Pro Lys Phe Phe Ser Asp Arg Glu Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Lys Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Ser Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
                1445                1450                1455    

Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Gln 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Leu Glu 
1505                1510                1515                1520

<210>   9
<211>   1521
<212>   PRT
<213>   Escherichia coli

<400>   9
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser 
            100                 105                 110         

Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala 
        115                 120                 125             

Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala 
    130                 135                 140                 

Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala 
145                 150                 155                 160 

Gln Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu 
                165                 170                 175     

Val Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu 
            180                 185                 190         

Glu Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys 
        195                 200                 205             

Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu 
    210                 215                 220                 

Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser 
225                 230                 235                 240 

Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala 
                245                 250                 255     

Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser 
            260                 265                 270         

Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly 
        275                 280                 285             

Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly 
    290                 295                 300                 

Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly 
305                 310                 315                 320 

Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile 
                325                 330                 335     

Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln 
            340                 345                 350         

Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val 
        355                 360                 365             

Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn 
    370                 375                 380                 

Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly 
385                 390                 395                 400 

Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr 
                405                 410                 415     

Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly 
            420                 425                 430         

Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp 
        435                 440                 445             

Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn 
    450                 455                 460                 

Tyr Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe 
465                 470                 475                 480 

Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser 
                485                 490                 495     

Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp 
            500                 505                 510         

Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr 
        515                 520                 525             

Ile Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp 
    530                 535                 540                 

Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu 
545                 550                 555                 560 

Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg 
                565                 570                 575     

Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln 
            580                 585                 590         

Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn 
        595                 600                 605             

Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala 
    610                 615                 620                 

Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His 
625                 630                 635                 640 

Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe 
                645                 650                 655     

Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro 
            660                 665                 670         

Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln 
        675                 680                 685             

Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys 
    690                 695                 700                 

Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn 
705                 710                 715                 720 

Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys 
                725                 730                 735     

Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu 
            740                 745                 750         

Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr 
        755                 760                 765             

Pro Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu 
    770                 775                 780                 

Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys 
785                 790                 795                 800 

Thr Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys 
            820                 825                 830         

Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu 
        835                 840                 845             

Asp Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly 
    850                 855                 860                 

Leu Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu 
865                 870                 875                 880 

Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Asp Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala 
            980                 985                 990         

Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn 
        995                 1000                1005            

Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala 
    1090                1095                1100                

Asn Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys 
                1125                1130                1135    

Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala 
        1155                1160                1165            

Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser 
                1205                1210                1215    

Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe 
            1220                1225                1230        

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Glu Thr Ser Gly Lys 
        1235                1240                1245            

His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe 
    1250                1255                1260                

Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
1265                1270                1275                1280

Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr 
                1285                1290                1295    

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala 
            1300                1305                1310        

Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
        1315                1320                1325            

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
    1330                1335                1340                

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly 
1345                1350                1355                1360

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
                1365                1370                1375    

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr 
            1380                1385                1390        

Pro Glu Gly Glu Leu Pro Lys Phe Phe Ser Asp Arg Glu Gly Met Lys 
        1395                1400                1405            

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp 
    1410                1415                1420                

Val Gly Asp Lys Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn 
1425                1430                1435                1440

Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
                1445                1450                1455    

Thr Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
            1460                1465                1470        

Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser 
        1475                1480                1485            

Gln Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu 
    1490                1495                1500                

Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Leu 
1505                1510                1515                1520

Glu 
    

<210>   10
<211>   1521
<212>   PRT
<213>   Escherichia coli

<400>   10
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser 
            100                 105                 110         

Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala 
        115                 120                 125             

Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala 
    130                 135                 140                 

Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala 
145                 150                 155                 160 

Gln Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu 
                165                 170                 175     

Val Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu 
            180                 185                 190         

Glu Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys 
        195                 200                 205             

Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu 
    210                 215                 220                 

Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser 
225                 230                 235                 240 

Pro Val Val Pro Ala Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala 
                245                 250                 255     

Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr 
            260                 265                 270         

Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Asp Gly 
        275                 280                 285             

Val Val Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly 
    290                 295                 300                 

Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly 
305                 310                 315                 320 

Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile 
                325                 330                 335     

Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln 
            340                 345                 350         

Leu Ile His Arg Tyr Ser Lys Ala Gly Gln Asn His Thr Arg Val Val 
        355                 360                 365             

Pro Asp Glu Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn 
    370                 375                 380                 

Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly 
385                 390                 395                 400 

Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr 
                405                 410                 415     

Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly 
            420                 425                 430         

Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp 
        435                 440                 445             

Gly Lys Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn 
    450                 455                 460                 

Tyr Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe 
465                 470                 475                 480 

Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser 
                485                 490                 495     

Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp 
            500                 505                 510         

Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr 
        515                 520                 525             

Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu 
    530                 535                 540                 

Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp 
545                 550                 555                 560 

Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg 
                565                 570                 575     

Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln 
            580                 585                 590         

Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn 
        595                 600                 605             

Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala 
    610                 615                 620                 

Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His 
625                 630                 635                 640 

Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe 
                645                 650                 655     

Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro 
            660                 665                 670         

Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln 
        675                 680                 685             

Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys 
    690                 695                 700                 

Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn 
705                 710                 715                 720 

Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys 
                725                 730                 735     

Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu 
            740                 745                 750         

Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr 
        755                 760                 765             

Pro Asn Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu 
    770                 775                 780                 

Arg Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr 
785                 790                 795                 800 

Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys 
            820                 825                 830         

Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro 
        835                 840                 845             

Glu Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly 
    850                 855                 860                 

Leu Glu Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu 
865                 870                 875                 880 

Glu Tyr Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Gln Tyr Thr Gln Leu Asp Leu Ser Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Leu Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Glu Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val 
            980                 985                 990         

Gly Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys 
        995                 1000                1005            

Met Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Val Val Asn Thr Asn Gly Glu Thr Val Thr Gln Asn Ile Asn Leu 
            1060                1065                1070        

Tyr Ser Ala Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Gln Glu Val Ser Ile Glu Ser Lys Ala Thr 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ser Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Glu Val Gln Ser Ala Asp 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys 
    1170                1175                1180                

Trp Gln His Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn 
                1205                1210                1215    

Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys 
        1395                1400                1405            

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu 
    1410                1415                1420                

Val Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn 
1425                1430                1435                1440

Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
                1445                1450                1455    

Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
            1460                1465                1470        

Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser 
        1475                1480                1485            

Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu 
    1490                1495                1500                

Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Val 
1505                1510                1515                1520

Glu 
    

<210>   11
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   11
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Asp Pro Glu Pro 
65                  70                  75                  80  

Thr Pro Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu 
                85                  90                  95      

Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu 
            100                 105                 110         

Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val 
        115                 120                 125             

Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala 
    130                 135                 140                 

Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala 
145                 150                 155                 160 

Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu 
                165                 170                 175     

Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu 
            180                 185                 190         

Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys 
        195                 200                 205             

Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu 
    210                 215                 220                 

Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser 
225                 230                 235                 240 

Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala 
                245                 250                 255     

Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr 
            260                 265                 270         

Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly 
        275                 280                 285             

Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp 
    290                 295                 300                 

Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly 
305                 310                 315                 320 

Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile 
                325                 330                 335     

Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln 
            340                 345                 350         

Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val 
        355                 360                 365             

Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn 
    370                 375                 380                 

Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly 
385                 390                 395                 400 

Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr 
                405                 410                 415     

Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asn Gly 
            420                 425                 430         

Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp 
        435                 440                 445             

Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn 
    450                 455                 460                 

Tyr Gln Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe 
465                 470                 475                 480 

Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser 
                485                 490                 495     

Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp 
            500                 505                 510         

Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr 
        515                 520                 525             

Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp 
    530                 535                 540                 

Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp 
545                 550                 555                 560 

Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg 
                565                 570                 575     

Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu 
            580                 585                 590         

Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn 
        595                 600                 605             

Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser 
    610                 615                 620                 

Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala 
625                 630                 635                 640 

Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe 
                645                 650                 655     

Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro 
            660                 665                 670         

Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln 
        675                 680                 685             

Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys 
    690                 695                 700                 

Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn 
705                 710                 715                 720 

Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys 
                725                 730                 735     

Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu 
            740                 745                 750         

Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr 
        755                 760                 765             

Pro Asp Arg Val Arg Gln Gln Arg Glu Lys Gly Ile Trp Val Tyr Glu 
    770                 775                 780                 

Arg Tyr Pro Phe Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Glu Thr 
785                 790                 795                 800 

Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys 
            820                 825                 830         

Gln Val Lys Arg Tyr Ala Phe Ile Asp Glu Ala Glu His Glu Thr Asn 
        835                 840                 845             

Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile Ile Lys Ala Phe Pro Gly 
    850                 855                 860                 

Leu Glu Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu 
865                 870                 875                 880 

Glu Tyr Arg Pro Gly Thr Asn Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Arg Tyr Thr Gln Leu Asn Leu Ser Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Glu Ile Glu Tyr Ser Tyr Asp Ser Ser Lys Glu Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr 
            980                 985                 990         

Lys Gly Thr Leu Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn 
        995                 1000                1005            

Lys Met Ile Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser 
    1010                1015                1020                

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
1025                1030                1035                1040

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
                1045                1050                1055    

Gly Ala Val Ser Val Gly Gly Glu Glu Val Thr Glu Thr Ile Ser Leu 
            1060                1065                1070        

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
        1075                1080                1085            

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn 
    1090                1095                1100                

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
1105                1110                1115                1120

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
                1125                1130                1135    

Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly 
            1140                1145                1150        

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser 
        1155                1160                1165            

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
    1170                1175                1180                

Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
1185                1190                1195                1200

Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn 
                1205                1210                1215    

Tyr Thr Gly Gly Leu Asp Gln Phe Ala Lys Asp Leu Asp Thr Phe Ala 
            1220                1225                1230        

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
        1235                1240                1245            

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
    1250                1255                1260                

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
1265                1270                1275                1280

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
                1285                1290                1295    

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
            1300                1305                1310        

Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
        1315                1320                1325            

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
    1330                1335                1340                

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln 
1345                1350                1355                1360

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
                1365                1370                1375    

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Thr Lys Trp Tyr Pro 
            1380                1385                1390        

Asp Gly Lys Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
    1410                1415                1420                

Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Ala Glu Met Ser Phe Glu Gly Gly Val Ser Ser 
        1475                1480                1485            

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Asn Leu Pro Lys Pro Glu Lys 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   12
<211>   1519
<212>   PRT
<213>   Escherichia coli

<400>   12
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
        275                 280                 285             

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
    290                 295                 300                 

Gly Glu Phe Ser Phe Ser Trp Gly Glu Ala Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln 
385                 390                 395                 400 

Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala 
    530                 535                 540                 

Ser Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
            580                 585                 590         

Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Ser Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Glu Thr Val Tyr Phe Lys Lys His Gly Gln 
625                 630                 635                 640 

Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Lys Asp Phe Thr Gly 
                645                 650                 655     

Ile Thr Val Lys Pro Met Thr Ser Tyr Gly Asn Leu Asn Pro Asp Glu 
            660                 665                 670         

Val Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Gly 
        675                 680                 685             

Ser Asp Pro Tyr Ser Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys 
785                 790                 795                 800 

Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro 
                805                 810                 815     

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
            820                 825                 830         

Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser 
        835                 840                 845             

Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu 
    850                 855                 860                 

Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
865                 870                 875                 880 

Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
                885                 890                 895     

Tyr Thr Gln Leu Asp Leu Ser Ala Asp Thr Ala Lys Ala Met Leu Gln 
            900                 905                 910         

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
        915                 920                 925             

Tyr Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser Val Asp 
    930                 935                 940                 

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu Thr 
945                 950                 955                 960 

Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
                965                 970                 975     

Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val Gly Thr 
            980                 985                 990         

Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys Met Ile 
        995                 1000                1005            

Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro 
    1010                1015                1020                

Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser 
1025                1030                1035                1040

Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Val 
                1045                1050                1055    

Val Asn Thr Asn Gly Glu Thr Val Thr Gln Asn Ile Asn Leu Tyr Ser 
            1060                1065                1070        

Ala Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp 
        1075                1080                1085            

Ala Pro Ala Gln Gln Glu Val Ser Ile Glu Ser Lys Ser Thr Val Pro 
    1090                1095                1100                

Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys 
1105                1110                1115                1120

His Glu Val Ser Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Asp 
                1125                1130                1135    

Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly Leu 
            1140                1145                1150        

Ile Tyr Ile Lys Gly Asp Ser Lys Glu Val Gln Ser Ala Asp Phe Thr 
        1155                1160                1165            

Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Gln 
    1170                1175                1180                

His Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser 
1185                1190                1195                1200

Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr 
                1205                1210                1215    

Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser 
            1220                1225                1230        

Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg Met 
        1235                1240                1245            

Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala Asn Asp 
    1250                1255                1260                

Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn 
1265                1270                1275                1280

Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn 
                1285                1290                1295    

Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro 
            1300                1305                1310        

Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu 
        1315                1320                1325            

Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp 
    1330                1335                1340                

Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp 
1345                1350                1355                1360

Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys 
                1365                1370                1375    

Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly 
            1380                1385                1390        

Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp 
        1395                1400                1405            

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val Ser 
    1410                1415                1420                

Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
1425                1430                1435                1440

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
                1445                1450                1455    

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
            1460                1465                1470        

Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser 
        1475                1480                1485            

Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly 
    1490                1495                1500                

Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                

<210>   13
<211>   1523
<212>   PRT
<213>   Escherichia coli

<400>   13
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
    130                 135                 140                 

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
145                 150                 155                 160 

Glu Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val 
                165                 170                 175     

Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr 
            180                 185                 190         

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
        195                 200                 205             

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
    210                 215                 220                 

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
225                 230                 235                 240 

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
                245                 250                 255     

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
            260                 265                 270         

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val 
        275                 280                 285             

Val Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu 
    290                 295                 300                 

Asn Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
305                 310                 315                 320 

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
                325                 330                 335     

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
            340                 345                 350         

Ile His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro 
        355                 360                 365             

Asp Val Val Arg Lys Val Phe Ala Ala Tyr Pro Asn Val Ile Asn Glu 
    370                 375                 380                 

Ile Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp 
385                 390                 395                 400 

Gln Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly 
                405                 410                 415     

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys 
            420                 425                 430         

Asn Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Glu Gly 
        435                 440                 445             

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr 
    450                 455                 460                 

Lys Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
465                 470                 475                 480 

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
                485                 490                 495     

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
            500                 505                 510         

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
        515                 520                 525             

Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr 
    530                 535                 540                 

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
545                 550                 555                 560 

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
                565                 570                 575     

Pro Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys 
            580                 585                 590         

Thr Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val 
        595                 600                 605             

Leu Arg Tyr Leu Ser Asn Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
    610                 615                 620                 

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
625                 630                 635                 640 

Gln Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala 
                645                 650                 655     

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
            660                 665                 670         

Lys Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
        675                 680                 685             

Gly Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro 
    690                 695                 700                 

Lys Leu Ser Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
705                 710                 715                 720 

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
                725                 730                 735     

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
            740                 745                 750         

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
        755                 760                 765             

Asp Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
    770                 775                 780                 

Tyr Pro Val Val Glu Gly Glu Leu Pro Tyr Thr Ile Asp Ser Lys Thr 
785                 790                 795                 800 

Gly Lys Val Thr Trp Lys Tyr Gln Ile Asp Asn Lys Pro Asp Lys Lys 
                805                 810                 815     

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Asp Gly Lys Gln 
            820                 825                 830         

Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Thr Glu 
        835                 840                 845             

Ser Leu Asp Ala Ala Lys Lys Lys Ile Leu Glu Lys Phe Lys Gly Leu 
    850                 855                 860                 

Glu Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
865                 870                 875                 880 

Tyr Arg Pro Gly Thr Asn Val Pro Ala Thr Gly Gly Met Tyr Val Pro 
                885                 890                 895     

Arg Tyr Thr Gln Leu Asn Leu Ser Ala Asp Thr Ala Lys Ala Met Val 
            900                 905                 910         

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
        915                 920                 925             

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
    930                 935                 940                 

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu 
945                 950                 955                 960 

Ile Glu Tyr Ser Tyr Asp Ser Ser Lys Glu Asp Glu Leu Gly Phe Lys 
                965                 970                 975     

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly 
            980                 985                 990         

Gly Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn 
        995                 1000                1005            

Met Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Glu Glu Gly Gln Glu Val Thr Glu Ser Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala 
    1090                1095                1100                

Asp Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys 
                1125                1130                1135    

Thr Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Lys Glu Asn Asn Lys Ser 
        1155                1160                1165            

Ala Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asn 
    1170                1175                1180                

Gly Ala Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu 
1185                1190                1195                1200

Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala 
                1205                1210                1215    

Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr 
            1220                1225                1230        

Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly 
        1235                1240                1245            

Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg 
    1250                1255                1260                

Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr 
1265                1270                1275                1280

Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr 
                1285                1290                1295    

Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala 
            1300                1305                1310        

Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn 
        1315                1320                1325            

Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg 
    1330                1335                1340                

Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn 
1345                1350                1355                1360

Asn Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr 
                1365                1370                1375    

Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp 
            1380                1385                1390        

Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly 
        1395                1400                1405            

Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly 
    1410                1415                1420                

Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Arg Asn Tyr Cys Ala Glu 
1425                1430                1435                1440

Ser Asn Gly Asn Thr Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val 
                1445                1450                1455    

Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala 
            1460                1465                1470        

Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly 
        1475                1480                1485            

Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys 
    1490                1495                1500                

Pro Lys Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met 
1505                1510                1515                1520

Pro Ala Glu 
            

<210>   14
<211>   1518
<212>   PRT
<213>   Escherichia coli

<400>   14
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
        275                 280                 285             

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
    290                 295                 300                 

Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln 
385                 390                 395                 400 

Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
            580                 585                 590         

Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Asn Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly Gln 
625                 630                 635                 640 

Val Thr Gly Asn Ser Ala Ala Phe Gly Phe His Pro Asp Phe Ala Gly 
                645                 650                 655     

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
            660                 665                 670         

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
        675                 680                 685             

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys 
785                 790                 795                 800 

Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro 
                805                 810                 815     

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
            820                 825                 830         

Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser 
        835                 840                 845             

Leu Ala Ala Ala Lys Lys Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu 
    850                 855                 860                 

Glu Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
865                 870                 875                 880 

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
                885                 890                 895     

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
            900                 905                 910         

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
        915                 920                 925             

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
    930                 935                 940                 

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile 
945                 950                 955                 960 

Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr 
                965                 970                 975     

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Asp Gly Gly 
            980                 985                 990         

Thr Gln Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn Lys Met 
        995                 1000                1005            

Ile Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro 
    1010                1015                1020                

Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser 
1025                1030                1035                1040

Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala 
                1045                1050                1055    

Val Ser Ala Glu Gly Glu Glu Val Thr Glu Thr Ile Asn Leu Tyr Ser 
            1060                1065                1070        

Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp 
        1075                1080                1085            

Ala Pro Ala Gln Gln Glu Val Ser Ile Lys Ser Asn Ala Lys Val Pro 
    1090                1095                1100                

Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys 
1105                1110                1115                1120

His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser 
                1125                1130                1135    

Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu 
            1140                1145                1150        

Ile Tyr Ile Lys Ser Asp Ser Lys Glu Glu Lys Ser Ala Asn Phe Thr 
        1155                1160                1165            

Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Lys 
    1170                1175                1180                

Asn Asp Leu Lys Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser 
1185                1190                1195                1200

Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Tyr Lys 
                1205                1210                1215    

Gly Gly Leu Lys Gln Phe Ala Glu Asp Leu Asp Thr Phe Ala Ser Ser 
            1220                1225                1230        

Met Asn Asp Phe Tyr Gly Arg Asp Gly Glu Ser Gly Lys His Arg Met 
        1235                1240                1245            

Phe Thr Tyr Glu Ala Leu Thr Gly His Lys His Arg Phe Thr Asn Asp 
    1250                1255                1260                

Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn 
1265                1270                1275                1280

Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn 
                1285                1290                1295    

Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro 
            1300                1305                1310        

Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu 
        1315                1320                1325            

Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp 
    1330                1335                1340                

Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp 
1345                1350                1355                1360

Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys 
                1365                1370                1375    

Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly 
            1380                1385                1390        

Ser Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn 
        1395                1400                1405            

Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn 
    1410                1415                1420                

Asp Lys Phe Gly Asn Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala 
1425                1430                1435                1440

Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu 
                1445                1450                1455    

Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu 
            1460                1465                1470        

Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala 
        1475                1480                1485            

Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Lys Gln Gly Pro 
    1490                1495                1500                

Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
1505                1510                1515            

<210>   15
<211>   1520
<212>   PRT
<213>   Escherichia coli

<400>   15
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
        275                 280                 285             

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
    290                 295                 300                 

Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln 
385                 390                 395                 400 

Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
            580                 585                 590         

Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asp Asp Lys Trp Lys Pro Asp Ala Lys Ala Ser Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
625                 630                 635                 640 

Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala Gly 
                645                 650                 655     

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
            660                 665                 670         

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
        675                 680                 685             

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn 
        755                 760                 765             

Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly 
785                 790                 795                 800 

Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro 
                805                 810                 815     

Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu 
            820                 825                 830         

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser 
        835                 840                 845             

Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu Lys 
    850                 855                 860                 

Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
865                 870                 875                 880 

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
                885                 890                 895     

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
            900                 905                 910         

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
        915                 920                 925             

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
    930                 935                 940                 

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
945                 950                 955                 960 

Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys Thr 
                965                 970                 975     

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
            980                 985                 990         

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
        995                 1000                1005            

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
    1010                1015                1020                

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
1025                1030                1035                1040

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
                1045                1050                1055    

Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu Tyr 
            1060                1065                1070        

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
        1075                1080                1085            

Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val 
    1090                1095                1100                

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
1105                1110                1115                1120

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
                1125                1130                1135    

Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly 
            1140                1145                1150        

Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe 
        1155                1160                1165            

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp 
    1170                1175                1180                

Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp 
1185                1190                1195                1200

Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
                1205                1210                1215    

Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser 
            1220                1225                1230        

Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg 
        1235                1240                1245            

Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Thr Asn 
    1250                1255                1260                

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
1265                1270                1275                1280

Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
                1285                1290                1295    

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
            1300                1305                1310        

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
        1315                1320                1325            

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
    1330                1335                1340                

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn Gln Ala 
1345                1350                1355                1360

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
                1365                1370                1375    

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp 
            1380                1385                1390        

Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
        1395                1400                1405            

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
    1410                1415                1420                

Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
1425                1430                1435                1440

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
                1445                1450                1455    

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
            1460                1465                1470        

Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
        1475                1480                1485            

Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln 
    1490                1495                1500                

Gly Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515                1520

<210>   16
<211>   1518
<212>   PRT
<213>   Escherichia coli

<400>   16
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Ser Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser 
    130                 135                 140                 

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
145                 150                 155                 160 

Leu Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
                165                 170                 175     

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
            180                 185                 190         

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
        195                 200                 205             

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
    210                 215                 220                 

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
225                 230                 235                 240 

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
                245                 250                 255     

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
            260                 265                 270         

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
        275                 280                 285             

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
    290                 295                 300                 

Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
305                 310                 315                 320 

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
                325                 330                 335     

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
            340                 345                 350         

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Glu 
        355                 360                 365             

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
    370                 375                 380                 

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln 
385                 390                 395                 400 

Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln 
                405                 410                 415     

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
            420                 425                 430         

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
        435                 440                 445             

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
    450                 455                 460                 

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
465                 470                 475                 480 

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
                485                 490                 495     

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
            500                 505                 510         

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
        515                 520                 525             

Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala 
    530                 535                 540                 

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys 
545                 550                 555                 560 

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
                565                 570                 575     

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
            580                 585                 590         

Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu 
        595                 600                 605             

Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Asn Met 
    610                 615                 620                 

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly Gln 
625                 630                 635                 640 

Val Thr Gly Asn Ser Ala Ala Phe Gly Phe His Pro Asp Phe Ala Gly 
                645                 650                 655     

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
            660                 665                 670         

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
        675                 680                 685             

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
    690                 695                 700                 

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly 
705                 710                 715                 720 

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
                725                 730                 735     

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
            740                 745                 750         

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
        755                 760                 765             

Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr 
    770                 775                 780                 

Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys 
785                 790                 795                 800 

Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro 
                805                 810                 815     

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
            820                 825                 830         

Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser 
        835                 840                 845             

Leu Ala Ala Ala Lys Lys Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu 
    850                 855                 860                 

Glu Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
865                 870                 875                 880 

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
                885                 890                 895     

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
            900                 905                 910         

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
        915                 920                 925             

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
    930                 935                 940                 

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile 
945                 950                 955                 960 

Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr 
                965                 970                 975     

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Asp Gly Gly 
            980                 985                 990         

Thr Gln Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn Lys Met 
        995                 1000                1005            

Ile Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro 
    1010                1015                1020                

Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser 
1025                1030                1035                1040

Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala 
                1045                1050                1055    

Val Ser Ala Glu Gly Glu Glu Val Thr Glu Thr Ile Asn Leu Tyr Ser 
            1060                1065                1070        

Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp 
        1075                1080                1085            

Ala Pro Ala Gln Gln Glu Val Ser Ile Lys Ser Asn Ala Lys Val Pro 
    1090                1095                1100                

Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys 
1105                1110                1115                1120

His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser 
                1125                1130                1135    

Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu 
            1140                1145                1150        

Ile Tyr Ile Lys Ser Asp Ser Lys Glu Glu Lys Ser Ala Asn Phe Thr 
        1155                1160                1165            

Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Lys 
    1170                1175                1180                

Asn Asp Leu Lys Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser 
1185                1190                1195                1200

Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Tyr Lys 
                1205                1210                1215    

Gly Gly Leu Lys Gln Phe Ala Glu Asp Leu Asp Thr Phe Ala Ser Ser 
            1220                1225                1230        

Met Asn Asp Phe Tyr Gly Arg Asp Gly Glu Ser Gly Lys His Arg Met 
        1235                1240                1245            

Phe Thr Tyr Glu Ala Leu Thr Gly His Lys His Arg Phe Thr Asn Asp 
    1250                1255                1260                

Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn 
1265                1270                1275                1280

Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn 
                1285                1290                1295    

Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro 
            1300                1305                1310        

Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu 
        1315                1320                1325            

Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp 
    1330                1335                1340                

Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp 
1345                1350                1355                1360

Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys 
                1365                1370                1375    

Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly 
            1380                1385                1390        

Ser Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn 
        1395                1400                1405            

Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn 
    1410                1415                1420                

Asp Lys Phe Gly Asn Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala 
1425                1430                1435                1440

Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu 
                1445                1450                1455    

Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu 
            1460                1465                1470        

Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala 
        1475                1480                1485            

Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly Pro 
    1490                1495                1500                

Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
1505                1510                1515            

<210>   17
<211>   1524
<212>   PRT
<213>   Escherichia coli

<400>   17
Met Asn Lys Lys Phe Lys Tyr Lys Lys Ser Leu Leu Ala Ala Ile Leu 
1               5                   10                  15      

Ser Ala Thr Leu Leu Ala Gly Cys Asp Gly Gly Gly Ser Gly Pro Ser 
            20                  25                  30          

Ser Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val 
        35                  40                  45              

Lys Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro 
    50                  55                  60                  

Asp Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro 
65                  70                  75                  80  

Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu 
                85                  90                  95      

Gly Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser 
            100                 105                 110         

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
        115                 120                 125             

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
    130                 135                 140                 

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
145                 150                 155                 160 

Glu Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val 
                165                 170                 175     

Thr Ser Ser Asn Ser Cys Pro Ala Asp Thr Glu Gln Val Cys Leu Thr 
            180                 185                 190         

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
        195                 200                 205             

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
    210                 215                 220                 

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
225                 230                 235                 240 

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
                245                 250                 255     

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
            260                 265                 270         

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val 
        275                 280                 285             

Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
    290                 295                 300                 

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
305                 310                 315                 320 

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
                325                 330                 335     

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
            340                 345                 350         

Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro 
        355                 360                 365             

Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
    370                 375                 380                 

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp 
385                 390                 395                 400 

Gln Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
                405                 410                 415     

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
            420                 425                 430         

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
        435                 440                 445             

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr 
    450                 455                 460                 

Lys Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
465                 470                 475                 480 

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
                485                 490                 495     

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
            500                 505                 510         

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
        515                 520                 525             

Thr Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr 
    530                 535                 540                 

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
545                 550                 555                 560 

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
                565                 570                 575     

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
            580                 585                 590         

Thr Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val 
        595                 600                 605             

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
    610                 615                 620                 

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
625                 630                 635                 640 

Gln Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala 
                645                 650                 655     

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
            660                 665                 670         

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
        675                 680                 685             

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
    690                 695                 700                 

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
705                 710                 715                 720 

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
                725                 730                 735     

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
            740                 745                 750         

Met Ala Leu Asn Lys Ser Val Val Asn Thr Asp Pro Gln Gly Tyr Pro 
        755                 760                 765             

Asn Arg Val Arg Gln Gln Arg Glu Lys Gly Ile Trp Val Tyr Glu Arg 
    770                 775                 780                 

Tyr Pro Ala Val Asp Ser Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asp 
785                 790                 795                 800 

Thr Gly Lys Val Thr Trp Lys Tyr Gln Glu Glu Gly Lys Pro Asp Asp 
                805                 810                 815     

Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Asp Val Asp Gly Lys 
            820                 825                 830         

Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu His Ser Thr Glu 
        835                 840                 845             

Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly 
    850                 855                 860                 

Leu Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu 
865                 870                 875                 880 

Glu Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val 
                885                 890                 895     

Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met 
            900                 905                 910         

Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His 
        915                 920                 925             

Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser 
    930                 935                 940                 

Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn 
945                 950                 955                 960 

Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe 
                965                 970                 975     

Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Ser 
            980                 985                 990         

Glu Gly Thr Gln Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn 
        995                 1000                1005            

Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro 
    1010                1015                1020                

Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu 
1025                1030                1035                1040

Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr 
                1045                1050                1055    

Pro Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser 
            1060                1065                1070        

Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr 
        1075                1080                1085            

Gly Leu Trp Ala Pro Ala Gln Gln Glu Val Thr Ile Glu Ser Thr Ala 
    1090                1095                1100                

Ser Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly 
1105                1110                1115                1120

Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys 
                1125                1130                1135    

Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr 
            1140                1145                1150        

Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Lys Asn Glu Ser Ala 
        1155                1160                1165            

Glu Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly 
    1170                1175                1180                

Glu Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
1185                1190                1195                1200

Ser Asp Ser Phe Val Tyr Thr Ala Pro Lys Asn Asn Leu Asn Ala Ser 
                1205                1210                1215    

Asn Tyr Ser Asn Tyr Thr Asp Gly Val Ala Glu Phe Ala Lys Glu Leu 
            1220                1225                1230        

Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Gly Glu 
        1235                1240                1245            

Ser Gly Asn His Arg Met Phe Thr Tyr Lys Ala Leu Thr Gly His Lys 
    1250                1255                1260                

His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser 
1265                1270                1275                1280

Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu 
                1285                1290                1295    

Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His 
            1300                1305                1310        

Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala 
        1315                1320                1325            

Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met 
    1330                1335                1340                

Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu 
1345                1350                1355                1360

Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu 
                1365                1370                1375    

Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys 
            1380                1385                1390        

Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys 
        1395                1400                1405            

Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg 
    1410                1415                1420                

Gly Asp Asp Val Ser Asn Asp Lys Phe Gly Gly Arg Asn Tyr Cys Ala 
1425                1430                1435                1440

Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp 
                1445                1450                1455    

Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly 
            1460                1465                1470        

Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly 
        1475                1480                1485            

Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ala Met His Leu Ser 
    1490                1495                1500                

Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser 
1505                1510                1515                1520

Met Pro Ala Glu 
                

<210>   18
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   3FW-SSLE

<400>   18
agttggcctt cggaaagaat                                              20

<210>   19
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   3REV-SSLE

<400>   19
caatttcagc aagctggtca                                              20

<210>   20
<211>   43
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 1

<400>   20
gagatataca tatggctagc gatacgccgt ctgtagattc tgg                    43

<210>   21
<211>   42
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 2

<400>   21
ttttcctttt gcggccgctt actcggcaga catcttatgc tc                     42

<210>   22
<211>   31
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 3

<400>   22
ctgatttggt atgttgtcgg ttataacgct g                                 31

<210>   23
<211>   31
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 4

<400>   23
cagcgttata accgacaaca taccaaatca g                                 31

<210>   24
<211>   33
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 5

<400>   24
gtgcgtctcg agctcggcag acatcttatg ctc                               33

<210>   25
<211>   51
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 6

<400>   25
cgatcatccg gcattattga cgctagccat atgtatatct ccttcttaaa g           51

<210>   26
<211>   43
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 7

<400>   26
gtggttcagg atcgtcctcc gatacgccgt ctgtagattc tgg                    43

<210>   27
<211>   47
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 8

<400>   27
gatatacata tggctagcgt caataatgcc ggatgatcgt taatatc                47

<210>   28
<211>   36
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer 9

<400>   28
ctacagacgg cgtatcggag gacgatcctg aaccac                            36

<210>   29
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   sslE-prom-fw

<400>   29
agtcaataat gccggatg                                                18

<210>   30
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   sslE-prom-rv

<400>   30
taataacgca agtgacaaaa                                              20

<210>   31
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   sslE-Forward

<400>   31
ccacctcttc attgaccagc                                              20

<210>   32
<211>   19
<212>   DNA
<213>   sslE-Reverse

<400>   32
gagccagaac ctgttccta                                               19

<210>   33
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   33
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             

Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     

Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         

Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             

Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 

Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly 
        755                 760                 765             

Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser 
                805                 810                 815     

Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln 
            820                 825                 830         

Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg 
        835                 840                 845             

Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 

Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
        915                 920                 925             

Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
945                 950                 955                 960 

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe 
    1170                1175                1180                

Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly 
            1380                1385                1390        

Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser Ser 
                1445                1450                1455    

Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   34
<211>   1488
<212>   PRT
<213>   Escherichia coli

<400>   34
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg Ser 
            100                 105                 110         

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
        115                 120                 125             

Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
    130                 135                 140                 

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
145                 150                 155                 160 

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
                165                 170                 175     

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
            180                 185                 190         

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
        195                 200                 205             

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
    210                 215                 220                 

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
225                 230                 235                 240 

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val Val 
                245                 250                 255     

Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu Asn 
            260                 265                 270         

Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
        275                 280                 285             

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
    290                 295                 300                 

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
305                 310                 315                 320 

His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro Asp 
                325                 330                 335     

Val Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
            340                 345                 350         

Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp Gln 
        355                 360                 365             

Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly Gln 
    370                 375                 380                 

Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys Asn 
385                 390                 395                 400 

Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Glu Gly Gln 
                405                 410                 415     

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr Lys 
            420                 425                 430         

Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
        435                 440                 445             

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
    450                 455                 460                 

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
465                 470                 475                 480 

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
                485                 490                 495     

Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala 
            500                 505                 510         

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
        515                 520                 525             

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
    530                 535                 540                 

Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys Thr 
545                 550                 555                 560 

Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val Leu 
                565                 570                 575     

Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met 
            580                 585                 590         

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
        595                 600                 605             

Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly 
    610                 615                 620                 

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
625                 630                 635                 640 

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
                645                 650                 655     

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
            660                 665                 670         

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
        675                 680                 685             

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
    690                 695                 700                 

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
705                 710                 715                 720 

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn 
                725                 730                 735     

Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
            740                 745                 750         

Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly 
        755                 760                 765             

Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser 
                805                 810                 815     

Leu Lys Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Lys 
            820                 825                 830         

Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
        835                 840                 845             

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
    850                 855                 860                 

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile 
        915                 920                 925             

Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Ser Ala Ser 
            1060                1065                1070        

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr 
    1090                1095                1100                

Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Gln Asn Glu Ser Ala Glu 
                1125                1130                1135    

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
            1140                1145                1150        

Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
        1155                1160                1165            

Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
    1170                1175                1180                

Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala 
1185                1190                1195                1200

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
                1205                1210                1215    

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
            1220                1225                1230        

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
        1235                1240                1245            

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
    1250                1255                1260                

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
1265                1270                1275                1280

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
                1285                1290                1295    

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
            1300                1305                1310        

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln 
        1315                1320                1325            

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
    1330                1335                1340                

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro 
1345                1350                1355                1360

Glu Gly Asp Leu Pro Lys Phe Tyr Ser Asp Arg Glu Gly Met Lys Gly 
                1365                1370                1375    

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
            1380                1385                1390        

Gly Lys Thr Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn Gly 
        1395                1400                1405            

Asn Ala Ala Asp Lys Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
    1410                1415                1420                

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
1425                1430                1435                1440

Gln Leu Pro Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser Gln 
                1445                1450                1455    

Ser Ala Tyr Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln Gln 
            1460                1465                1470        

Gly Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485            

<210>   35
<211>   1488
<212>   PRT
<213>   Escherichia coli

<400>   35
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg Ser 
            100                 105                 110         

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
        115                 120                 125             

Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
    130                 135                 140                 

Ser Ser Asn Ser Cys Pro Ala Asp Thr Glu Gln Val Cys Leu Thr Phe 
145                 150                 155                 160 

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
                165                 170                 175     

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
            180                 185                 190         

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
        195                 200                 205             

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
    210                 215                 220                 

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
225                 230                 235                 240 

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val Val 
                245                 250                 255     

Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu Asn 
            260                 265                 270         

Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
        275                 280                 285             

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
    290                 295                 300                 

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
305                 310                 315                 320 

His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro Asp 
                325                 330                 335     

Val Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
            340                 345                 350         

Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp Gln 
        355                 360                 365             

Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly Gln 
    370                 375                 380                 

Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys Asn 
385                 390                 395                 400 

Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Asp Gly Gln 
                405                 410                 415     

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys 
            420                 425                 430         

Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
        435                 440                 445             

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
    450                 455                 460                 

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
465                 470                 475                 480 

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
                485                 490                 495     

Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala 
            500                 505                 510         

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
        515                 520                 525             

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
    530                 535                 540                 

Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys Thr 
545                 550                 555                 560 

Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val Leu 
                565                 570                 575     

Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met 
            580                 585                 590         

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
        595                 600                 605             

Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly 
    610                 615                 620                 

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
625                 630                 635                 640 

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
                645                 650                 655     

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
            660                 665                 670         

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
        675                 680                 685             

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
    690                 695                 700                 

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
705                 710                 715                 720 

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn 
                725                 730                 735     

Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
            740                 745                 750         

Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly 
        755                 760                 765             

Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser 
                805                 810                 815     

Leu Lys Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Lys 
            820                 825                 830         

Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr 
        835                 840                 845             

Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln 
    850                 855                 860                 

Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile 
        915                 920                 925             

Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Thr Ala Ser 
            1060                1065                1070        

Val Ala Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr 
    1090                1095                1100                

Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Gln Asn Glu Ser Ala Glu 
                1125                1130                1135    

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
            1140                1145                1150        

Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
        1155                1160                1165            

Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn 
    1170                1175                1180                

Tyr Lys Gly Gly Gln Glu Gln Phe Ala Glu Glu Leu Asp Thr Phe Ala 
1185                1190                1195                1200

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His 
                1205                1210                1215    

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
            1220                1225                1230        

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
        1235                1240                1245            

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
    1250                1255                1260                

Leu Asn Asp Trp Leu Ile Trp His Glu Ala Gly His Asn Ala Ala Glu 
1265                1270                1275                1280

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
                1285                1290                1295    

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
            1300                1305                1310        

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn Gln 
        1315                1320                1325            

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
    1330                1335                1340                

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Thr Lys Trp Tyr Pro 
1345                1350                1355                1360

Glu Gly Asn Leu Pro Lys Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
                1365                1370                1375    

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
            1380                1385                1390        

Gly Lys Thr Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn Gly 
        1395                1400                1405            

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
    1410                1415                1420                

Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
1425                1430                1435                1440

Gln Leu Pro Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser Gln 
                1445                1450                1455    

Ser Ala Tyr Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln Gln 
            1460                1465                1470        

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
        1475                1480                1485            

<210>   36
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   36
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr Leu 
545                 550                 555                 560 

Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asp Asp Lys Trp Lys Pro Asp Ala Lys Ala Ser Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln Val 
        595                 600                 605             

Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala Gly Ile 
    610                 615                 620                 

Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Asn 
                645                 650                 655     

Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg 
                725                 730                 735     

Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly Glu 
        755                 760                 765             

Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu Thr 
785                 790                 795                 800 

Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser Leu 
                805                 810                 815     

Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu Lys Glu 
            820                 825                 830         

Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr 
    850                 855                 860                 

Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr Ser 
        915                 920                 925             

Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr 
945                 950                 955                 960 

Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile 
                965                 970                 975     

Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro 
            980                 985                 990         

Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser 
        995                 1000                1005            

Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala 
    1010                1015                1020                

Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu Tyr Ser 
1025                1030                1035                1040

Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp 
                1045                1050                1055    

Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val Pro 
            1060                1065                1070        

Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys 
        1075                1080                1085            

His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser 
    1090                1095                1100                

Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu 
1105                1110                1115                1120

Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe Thr 
                1125                1130                1135    

Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys 
            1140                1145                1150        

Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala 
        1155                1160                1165            

Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr 
    1170                1175                1180                

Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser 
1185                1190                1195                1200

Met Asn Asp Phe His Gly Arg Asp Ser Glu Asp Gly Lys His Arg Met 
                1205                1210                1215    

Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Thr Asn Asp 
            1220                1225                1230        

Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn 
        1235                1240                1245            

Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn 
    1250                1255                1260                

Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro 
1265                1270                1275                1280

Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu 
                1285                1290                1295    

Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp 
            1300                1305                1310        

Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn Gln Ala Trp 
        1315                1320                1325            

Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys 
    1330                1335                1340                

Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly 
1345                1350                1355                1360

Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val Ser 
            1380                1385                1390        

Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser 
                1445                1450                1455    

Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   37
<211>   1489
<212>   PRT
<213>   Escherichia coli

<400>   37
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser Ser 
65                  70                  75                  80  

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
                85                  90                  95      

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu Val 
    130                 135                 140                 

Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Glu 
145                 150                 155                 160 

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
        195                 200                 205             

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val 
                245                 250                 255     

Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
            260                 265                 270         

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro 
                325                 330                 335     

Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Glu 
        355                 360                 365             

Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
545                 550                 555                 560 

Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
        595                 600                 605             

Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala 
    610                 615                 620                 

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
625                 630                 635                 640 

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
                645                 650                 655     

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr 
        755                 760                 765             

Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln 
785                 790                 795                 800 

Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp 
                805                 810                 815     

Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu 
            820                 825                 830         

Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Cys Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
        915                 920                 925             

Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
945                 950                 955                 960 

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
                965                 970                 975     

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn 
            1060                1065                1070        

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
    1090                1095                1100                

Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser 
                1125                1130                1135    

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
            1140                1145                1150        

Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
        1155                1160                1165            

Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn 
    1170                1175                1180                

Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala 
1185                1190                1195                1200

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His 
                1205                1210                1215    

Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala 
            1220                1225                1230        

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
        1235                1240                1245            

Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro 
    1250                1255                1260                

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
1265                1270                1275                1280

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
                1285                1290                1295    

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
            1300                1305                1310        

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln 
        1315                1320                1325            

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
    1330                1335                1340                

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro 
1345                1350                1355                1360

Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys 
                1365                1370                1375    

Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu 
            1380                1385                1390        

Val Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn 
        1395                1400                1405            

Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln 
    1410                1415                1420                

Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala 
1425                1430                1435                1440

Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser 
                1445                1450                1455    

Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu 
            1460                1465                1470        

Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Val 
        1475                1480                1485            

Glu 
    

<210>   38
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   38
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser Ser 
65                  70                  75                  80  

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
                85                  90                  95      

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu Val 
    130                 135                 140                 

Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Glu 
145                 150                 155                 160 

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
        195                 200                 205             

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val 
                245                 250                 255     

Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
            260                 265                 270         

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro 
                325                 330                 335     

Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu 
        355                 360                 365             

Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Asp Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
545                 550                 555                 560 

Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Ser 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly 
        595                 600                 605             

Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Lys Asp Phe Thr 
    610                 615                 620                 

Gly Ile Thr Val Lys Pro Met Thr Ser Tyr Gly Asn Leu Asn Pro Asp 
625                 630                 635                 640 

Glu Val Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp 
                645                 650                 655     

Gly Ser Asp Pro Tyr Ser Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asp Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr 
        755                 760                 765             

Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
785                 790                 795                 800 

Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu 
                805                 810                 815     

Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly Leu 
            820                 825                 830         

Glu Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Ser Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Gln Tyr Thr Gln Leu Asp Leu Gly Ala Asp Thr Ala Lys Ala Met Leu 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu 
        915                 920                 925             

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys Met 
                965                 970                 975     

Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp 
        1155                1160                1165            

Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
    1170                1175                1180                

Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Ser Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Ala Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Glu 
1345                1350                1355                1360

Gly Glu Leu Pro Lys Phe Phe Ser Asp Arg Glu Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly 
            1380                1385                1390        

Asn Lys Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Ser Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
    1410                1415                1420                

Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser 
                1445                1450                1455    

Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Gln Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Leu Glu 
        1475                1480                1485        

<210>   39
<211>   1488
<212>   PRT
<213>   Escherichia coli

<400>   39
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser Ser 
65                  70                  75                  80  

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
                85                  90                  95      

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu Val 
    130                 135                 140                 

Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Glu 
145                 150                 155                 160 

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
        195                 200                 205             

Val Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Ser Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val 
                245                 250                 255     

Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
            260                 265                 270         

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro 
                325                 330                 335     

Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Glu 
        355                 360                 365             

Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
545                 550                 555                 560 

Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
        595                 600                 605             

Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala 
    610                 615                 620                 

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
625                 630                 635                 640 

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
                645                 650                 655     

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asn Arg Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr 
        755                 760                 765             

Gly Glu Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln 
785                 790                 795                 800 

Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp 
                805                 810                 815     

Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu 
            820                 825                 830         

Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp 
        915                 920                 925             

Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly 
945                 950                 955                 960 

Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
                965                 970                 975     

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn 
            1060                1065                1070        

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr 
    1090                1095                1100                

Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser 
                1125                1130                1135    

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala 
            1140                1145                1150        

Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
        1155                1160                1165            

Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn 
    1170                1175                1180                

Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala 
1185                1190                1195                1200

Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Glu Thr Ser Gly Lys His 
                1205                1210                1215    

Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr 
            1220                1225                1230        

Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val 
        1235                1240                1245            

Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro 
    1250                1255                1260                

Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu 
1265                1270                1275                1280

Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu 
                1285                1290                1295    

Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala 
            1300                1305                1310        

Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln 
        1315                1320                1325            

Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln 
    1330                1335                1340                

Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro 
1345                1350                1355                1360

Glu Gly Glu Leu Pro Lys Phe Phe Ser Asp Arg Glu Gly Met Lys Gly 
                1365                1370                1375    

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val 
            1380                1385                1390        

Gly Asp Lys Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
        1395                1400                1405            

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
    1410                1415                1420                

Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
1425                1430                1435                1440

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
                1445                1450                1455    

Ser Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Gln 
            1460                1465                1470        

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Leu Glu 
        1475                1480                1485            

<210>   40
<211>   1488
<212>   PRT
<213>   Escherichia coli

<400>   40
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser Ser 
65                  70                  75                  80  

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
                85                  90                  95      

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu Val 
    130                 135                 140                 

Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Glu 
145                 150                 155                 160 

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
        195                 200                 205             

Val Val Pro Ala Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Asp Gly Val 
                245                 250                 255     

Val Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
            260                 265                 270         

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Lys Ala Gly Gln Asn His Thr Arg Val Val Pro 
                325                 330                 335     

Asp Glu Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu 
        355                 360                 365             

Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Lys Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
545                 550                 555                 560 

Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly 
        595                 600                 605             

Gln Val Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala 
    610                 615                 620                 

Gly Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln 
625                 630                 635                 640 

Glu Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val 
                645                 650                 655     

Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asn Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr 
        755                 760                 765             

Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
785                 790                 795                 800 

Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu 
                805                 810                 815     

Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly Leu 
            820                 825                 830         

Glu Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Gln Tyr Thr Gln Leu Asp Leu Ser Ala Asp Thr Ala Lys Ala Met Leu 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu 
        915                 920                 925             

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys Met 
                965                 970                 975     

Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Val Val Asn Thr Asn Gly Glu Thr Val Thr Gln Asn Ile Asn Leu Tyr 
1025                1030                1035                1040

Ser Ala Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Glu Val Ser Ile Glu Ser Lys Ala Thr Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ser Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Glu Val Gln Ser Ala Asp Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp 
            1140                1145                1150        

Gln His Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
    1170                1175                1180                

Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
                1365                1370                1375    

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
            1380                1385                1390        

Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
        1395                1400                1405            

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
    1410                1415                1420                

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
1425                1430                1435                1440

Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
                1445                1450                1455    

Ser Ala Tyr Asn Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Gln 
            1460                1465                1470        

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Val Glu 
        1475                1480                1485            

<210>   41
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   41
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Asp Pro Glu Pro Thr 
        35                  40                  45              

Pro Glu Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr 
    50                  55                  60                  

Leu Gly Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser 
65                  70                  75                  80  

Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val 
                85                  90                  95      

Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val 
    130                 135                 140                 

Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr 
145                 150                 155                 160 

Phe Ser Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr 
        195                 200                 205             

Val Val Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val 
                245                 250                 255     

Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu 
            260                 265                 270         

Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro 
                325                 330                 335     

Asp Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp 
        355                 360                 365             

Gln Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asn Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Gln Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys 
545                 550                 555                 560 

Thr Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly 
        595                 600                 605             

Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr 
    610                 615                 620                 

Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu 
625                 630                 635                 640 

Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp 
                645                 650                 655     

Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asp Arg Val Arg Gln Gln Arg Glu Lys Gly Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Phe Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Glu Thr Thr 
        755                 760                 765             

Lys Glu Val Ile Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln 
785                 790                 795                 800 

Val Lys Arg Tyr Ala Phe Ile Asp Glu Ala Glu His Glu Thr Asn Glu 
                805                 810                 815     

Ser Leu Glu Ala Ala Lys Ala Lys Ile Ile Lys Ala Phe Pro Gly Leu 
            820                 825                 830         

Glu Glu Cys Lys Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Thr Asn Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Arg Tyr Thr Gln Leu Asn Leu Ser Ala Asp Thr Ala Lys Ala Met Val 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu 
        915                 920                 925             

Ile Glu Tyr Ser Tyr Asp Ser Ser Lys Glu Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Lys 
945                 950                 955                 960 

Gly Thr Leu Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn Lys 
                965                 970                 975     

Met Ile Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ala Val Ser Val Gly Gly Glu Glu Val Thr Glu Thr Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Ser Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
    1170                1175                1180                

Thr Gly Gly Leu Asp Gln Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Thr Lys Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Lys Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly 
            1380                1385                1390        

Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Ala Glu Met Ser Phe Glu Gly Gly Val Ser Ser Ser 
                1445                1450                1455    

Ala Tyr Ser Thr Leu Ala Ser Leu Asn Leu Pro Lys Pro Glu Lys Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   42
<211>   1486
<212>   PRT
<213>   Escherichia coli

<400>   42
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Ala Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala Ser 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr Leu 
545                 550                 555                 560 

Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Ser Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Thr Val Tyr Phe Lys Lys His Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Lys Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Pro Met Thr Ser Tyr Gly Asn Leu Asn Pro Asp Glu Val 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Gly Ser 
                645                 650                 655     

Asp Pro Tyr Ser Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu 
        755                 760                 765             

Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr 
785                 790                 795                 800 

Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser Leu 
                805                 810                 815     

Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu Val 
            820                 825                 830         

Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr 
    850                 855                 860                 

Thr Gln Leu Asp Leu Ser Ala Asp Thr Ala Lys Ala Met Leu Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Gln Gly Glu Arg Leu Asn Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu Thr Lys 
        915                 920                 925             

Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val Gly Thr Gln 
945                 950                 955                 960 

Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys Met Ile Tyr 
                965                 970                 975     

Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu 
            980                 985                 990         

Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp 
        995                 1000                1005            

Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Val Val 
    1010                1015                1020                

Asn Thr Asn Gly Glu Thr Val Thr Gln Asn Ile Asn Leu Tyr Ser Ala 
1025                1030                1035                1040

Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala 
                1045                1050                1055    

Pro Ala Gln Gln Glu Val Ser Ile Glu Ser Lys Ser Thr Val Pro Val 
            1060                1065                1070        

Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His 
        1075                1080                1085            

Glu Val Ser Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Asp Leu 
    1090                1095                1100                

Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile 
1105                1110                1115                1120

Tyr Ile Lys Gly Asp Ser Lys Glu Val Gln Ser Ala Asp Phe Thr Phe 
                1125                1130                1135    

Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Gln His 
            1140                1145                1150        

Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe 
        1155                1160                1165            

Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly 
    1170                1175                1180                

Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser Met 
1185                1190                1195                1200

Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg Met Phe 
                1205                1210                1215    

Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala Asn Asp Val 
            1220                1225                1230        

Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser 
        1235                1240                1245            

Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp 
    1250                1255                1260                

Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu 
1265                1270                1275                1280

Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr 
                1285                1290                1295    

Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile 
            1300                1305                1310        

Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala 
        1315                1320                1325            

Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu 
    1330                1335                1340                

Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly Thr 
1345                1350                1355                1360

Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn 
                1365                1370                1375    

Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val Ser Asn 
            1380                1385                1390        

Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala 
        1395                1400                1405            

Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu 
    1410                1415                1420                

Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu 
1425                1430                1435                1440

Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala 
                1445                1450                1455    

Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly Pro 
            1460                1465                1470        

Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485    

<210>   43
<211>   1490
<212>   PRT
<213>   Escherichia coli

<400>   43
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg Ser 
            100                 105                 110         

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
        115                 120                 125             

Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
    130                 135                 140                 

Ser Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe 
145                 150                 155                 160 

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
                165                 170                 175     

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
            180                 185                 190         

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
        195                 200                 205             

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
    210                 215                 220                 

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
225                 230                 235                 240 

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val Val 
                245                 250                 255     

Gly Val Asn Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu Asn 
            260                 265                 270         

Gly Lys Phe Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
        275                 280                 285             

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
    290                 295                 300                 

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
305                 310                 315                 320 

His Arg Tyr Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro Asp 
                325                 330                 335     

Val Val Arg Lys Val Phe Ala Ala Tyr Pro Asn Val Ile Asn Glu Ile 
            340                 345                 350         

Ile Asn Leu Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp Gln 
        355                 360                 365             

Thr Phe Glu Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly Gln 
    370                 375                 380                 

Ala Lys Glu Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys Asn 
385                 390                 395                 400 

Ser Gln Arg Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Glu Gly Gln 
                405                 410                 415     

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr Lys 
            420                 425                 430         

Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
        435                 440                 445             

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
    450                 455                 460                 

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
465                 470                 475                 480 

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
                485                 490                 495     

Glu Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala 
            500                 505                 510         

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
        515                 520                 525             

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
    530                 535                 540                 

Asn Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys Thr 
545                 550                 555                 560 

Arg Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val Leu 
                565                 570                 575     

Arg Tyr Leu Ser Asn Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met 
            580                 585                 590         

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
        595                 600                 605             

Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly 
    610                 615                 620                 

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Lys 
625                 630                 635                 640 

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
                645                 650                 655     

Gly Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
            660                 665                 670         

Leu Ser Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
        675                 680                 685             

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
    690                 695                 700                 

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
705                 710                 715                 720 

Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp 
                725                 730                 735     

Arg Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr 
            740                 745                 750         

Pro Val Val Glu Gly Glu Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly 
        755                 760                 765             

Lys Val Thr Trp Lys Tyr Gln Ile Asp Asn Lys Pro Asp Lys Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Asp Gly Lys Gln Val 
785                 790                 795                 800 

Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Thr Glu Ser 
                805                 810                 815     

Leu Asp Ala Ala Lys Lys Lys Ile Leu Glu Lys Phe Lys Gly Leu Glu 
            820                 825                 830         

Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Tyr 
        835                 840                 845             

Arg Pro Gly Thr Asn Val Pro Ala Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 

Tyr Thr Gln Leu Asn Leu Ser Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu Ile 
        915                 920                 925             

Glu Tyr Ser Tyr Asp Ser Ser Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Glu Glu Gly Gln Glu Val Thr Glu Ser Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asp 
            1060                1065                1070        

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr 
    1090                1095                1100                

Tyr Glu Leu Lys Ala Asn Gly Glu Val Lys Phe Thr Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Lys Glu Asn Asn Lys Ser Ala 
                1125                1130                1135    

Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asn Gly 
            1140                1145                1150        

Ala Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu 
        1155                1160                1165            

Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser 
    1170                1175                1180                

Asn Phe Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe 
1185                1190                1195                1200

Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys 
                1205                1210                1215    

His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe 
            1220                1225                1230        

Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro 
        1235                1240                1245            

Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr 
    1250                1255                1260                

Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala 
1265                1270                1275                1280

Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val 
                1285                1290                1295    

Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val 
            1300                1305                1310        

Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn 
        1315                1320                1325            

Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala 
    1330                1335                1340                

Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr 
1345                1350                1355                1360

Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met 
                1365                1370                1375    

Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp 
            1380                1385                1390        

Glu Val Ser Asn Asp Lys Phe Gly Gly Arg Asn Tyr Cys Ala Glu Ser 
        1395                1400                1405            

Asn Gly Asn Thr Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala 
    1410                1415                1420                

Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn 
1425                1430                1435                1440

Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val 
                1445                1450                1455    

Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro 
            1460                1465                1470        

Lys Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro 
        1475                1480                1485            

Ala Glu 
    1490

<210>   44
<211>   1485
<212>   PRT
<213>   Escherichia coli

<400>   44
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr Leu 
545                 550                 555                 560 

Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Asn Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly Gln Val 
        595                 600                 605             

Thr Gly Asn Ser Ala Ala Phe Gly Phe His Pro Asp Phe Ala Gly Ile 
    610                 615                 620                 

Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Asn 
                645                 650                 655     

Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu 
        755                 760                 765             

Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr 
785                 790                 795                 800 

Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser Leu 
                805                 810                 815     

Ala Ala Ala Lys Lys Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu Glu 
            820                 825                 830         

Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr 
    850                 855                 860                 

Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile Glu 
        915                 920                 925             

Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Asp Gly Gly Thr 
945                 950                 955                 960 

Gln Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn Lys Met Ile 
                965                 970                 975     

Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu 
            980                 985                 990         

Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp 
        995                 1000                1005            

Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val 
    1010                1015                1020                

Ser Ala Glu Gly Glu Glu Val Thr Glu Thr Ile Asn Leu Tyr Ser Asn 
1025                1030                1035                1040

Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala 
                1045                1050                1055    

Pro Ala Gln Gln Glu Val Ser Ile Lys Ser Asn Ala Lys Val Pro Val 
            1060                1065                1070        

Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His 
        1075                1080                1085            

Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser Leu 
    1090                1095                1100                

Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu Ile 
1105                1110                1115                1120

Tyr Ile Lys Ser Asp Ser Lys Glu Glu Lys Ser Ala Asn Phe Thr Phe 
                1125                1130                1135    

Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Lys Asn 
            1140                1145                1150        

Asp Leu Lys Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe 
        1155                1160                1165            

Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Tyr Lys Gly 
    1170                1175                1180                

Gly Leu Lys Gln Phe Ala Glu Asp Leu Asp Thr Phe Ala Ser Ser Met 
1185                1190                1195                1200

Asn Asp Phe Tyr Gly Arg Asp Gly Glu Ser Gly Lys His Arg Met Phe 
                1205                1210                1215    

Thr Tyr Glu Ala Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val 
            1220                1225                1230        

Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser 
        1235                1240                1245            

Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp 
    1250                1255                1260                

Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu 
1265                1270                1275                1280

Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr 
                1285                1290                1295    

Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile 
            1300                1305                1310        

Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala 
        1315                1320                1325            

Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu 
    1330                1335                1340                

Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly Ser 
1345                1350                1355                1360

Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu 
                1365                1370                1375    

Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn Asp 
            1380                1385                1390        

Lys Phe Gly Asn Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala 
        1395                1400                1405            

Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser 
    1410                1415                1420                

Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro 
1425                1430                1435                1440

Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr 
                1445                1450                1455    

Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Lys Gln Gly Pro Glu 
            1460                1465                1470        

Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
        1475                1480                1485

<210>   45
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   45
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr Leu 
545                 550                 555                 560 

Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asp Asp Lys Trp Lys Pro Asp Ala Lys Ala Ser Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln Val 
        595                 600                 605             

Thr Gly Asn Ser Ala Ala Phe Asp Phe His Pro Asp Phe Ala Gly Ile 
    610                 615                 620                 

Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Asn 
                645                 650                 655     

Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg 
                725                 730                 735     

Val Arg Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Val Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly Glu 
        755                 760                 765             

Val Lys Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu Thr 
785                 790                 795                 800 

Arg Tyr Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser Leu 
                805                 810                 815     

Lys Ala Ala Lys Glu Lys Ile Phe Ala Ala Phe Pro Gly Leu Lys Glu 
            820                 825                 830         

Cys Thr Asn Pro Ala Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr 
    850                 855                 860                 

Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr Ser 
        915                 920                 925             

Tyr Arg Tyr Glu Glu Gly Lys Asn Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr 
945                 950                 955                 960 

Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile 
                965                 970                 975     

Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro 
            980                 985                 990         

Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser 
        995                 1000                1005            

Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala 
    1010                1015                1020                

Val Ser Glu Glu Gly Gln Asn Val Thr Glu Thr Ile Ser Leu Tyr Ser 
1025                1030                1035                1040

Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp 
                1045                1050                1055    

Ala Pro Ala Gln Lys Glu Val Thr Ile Lys Ser Asn Ala Asn Val Pro 
            1060                1065                1070        

Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys 
        1075                1080                1085            

His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser 
    1090                1095                1100                

Leu Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu 
1105                1110                1115                1120

Ile Tyr Ile Lys Gly Asn Ser Ser Thr Asn Glu Ser Ala Ser Phe Thr 
                1125                1130                1135    

Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys 
            1140                1145                1150        

Asn Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala 
        1155                1160                1165            

Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr 
    1170                1175                1180                

Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser 
1185                1190                1195                1200

Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg Met 
                1205                1210                1215    

Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Thr Asn Asp 
            1220                1225                1230        

Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn 
        1235                1240                1245            

Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn 
    1250                1255                1260                

Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro 
1265                1270                1275                1280

Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu 
                1285                1290                1295    

Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp 
            1300                1305                1310        

Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Asn Gln Ala Trp 
        1315                1320                1325            

Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys 
    1330                1335                1340                

Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly 
1345                1350                1355                1360

Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val Ser 
            1380                1385                1390        

Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser 
                1445                1450                1455    

Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   46
<211>   1485
<212>   PRT
<213>   Escherichia coli

<400>   46
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Lys Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Gly Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Glu Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Asn Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr Leu 
545                 550                 555                 560 

Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Asn Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly Gln Val 
        595                 600                 605             

Thr Gly Asn Ser Ala Ala Phe Gly Phe His Pro Asp Phe Ala Gly Ile 
    610                 615                 620                 

Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Asn 
                645                 650                 655     

Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu 
        755                 760                 765             

Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val Thr 
785                 790                 795                 800 

Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu Ser Leu 
                805                 810                 815     

Ala Ala Ala Lys Lys Arg Ile Leu Asp Ala Phe Pro Gly Leu Glu Glu 
            820                 825                 830         

Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr 
    850                 855                 860                 

Thr Gln Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile Glu 
        915                 920                 925             

Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Asp Gly Gly Thr 
945                 950                 955                 960 

Gln Cys Ser Ala Glu Leu Lys Gln Ser Leu Ile Asp Asn Lys Met Ile 
                965                 970                 975     

Tyr Gly Glu Gly Ser Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu 
            980                 985                 990         

Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp 
        995                 1000                1005            

Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val 
    1010                1015                1020                

Ser Ala Glu Gly Glu Glu Val Thr Glu Thr Ile Asn Leu Tyr Ser Asn 
1025                1030                1035                1040

Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala 
                1045                1050                1055    

Pro Ala Gln Gln Glu Val Ser Ile Lys Ser Asn Ala Lys Val Pro Val 
            1060                1065                1070        

Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His 
        1075                1080                1085            

Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser Leu 
    1090                1095                1100                

Asp Ala Ser Gly Thr Val Lys Phe Lys Val Pro Tyr Gly Gly Leu Ile 
1105                1110                1115                1120

Tyr Ile Lys Ser Asp Ser Lys Glu Glu Lys Ser Ala Asn Phe Thr Phe 
                1125                1130                1135    

Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp Lys Asn 
            1140                1145                1150        

Asp Leu Lys Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe 
        1155                1160                1165            

Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Tyr Lys Gly 
    1170                1175                1180                

Gly Leu Lys Gln Phe Ala Glu Asp Leu Asp Thr Phe Ala Ser Ser Met 
1185                1190                1195                1200

Asn Asp Phe Tyr Gly Arg Asp Gly Glu Ser Gly Lys His Arg Met Phe 
                1205                1210                1215    

Thr Tyr Glu Ala Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val 
            1220                1225                1230        

Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser 
        1235                1240                1245            

Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp 
    1250                1255                1260                

Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu 
1265                1270                1275                1280

Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr 
                1285                1290                1295    

Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile 
            1300                1305                1310        

Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala 
        1315                1320                1325            

Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu 
    1330                1335                1340                

Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly Ser 
1345                1350                1355                1360

Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu 
                1365                1370                1375    

Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly Asn Asp 
            1380                1385                1390        

Lys Phe Gly Asn Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala 
        1395                1400                1405            

Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser 
    1410                1415                1420                

Ala Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro 
1425                1430                1435                1440

Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr 
                1445                1450                1455    

Asn Thr Leu Ala Ser Leu Asp Leu Pro Lys Pro Glu Gln Gly Pro Glu 
            1460                1465                1470        

Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485

<210>   47
<211>   1491
<212>   PRT
<213>   Escherichia coli

<400>   47
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Ile Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg Ser 
            100                 105                 110         

Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu 
        115                 120                 125             

Leu Ala Ala Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr 
    130                 135                 140                 

Ser Ser Asn Ser Cys Pro Ala Asp Thr Glu Gln Val Cys Leu Thr Phe 
145                 150                 155                 160 

Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile 
                165                 170                 175     

Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu 
            180                 185                 190         

Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val 
        195                 200                 205             

Val Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe 
    210                 215                 220                 

Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile 
225                 230                 235                 240 

Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala 
                245                 250                 255     

Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn 
            260                 265                 270         

Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp 
        275                 280                 285             

Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu 
    290                 295                 300                 

Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile 
305                 310                 315                 320 

His Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp 
                325                 330                 335     

Asp Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile 
            340                 345                 350         

Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln 
        355                 360                 365             

Asn Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln 
    370                 375                 380                 

Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn 
385                 390                 395                 400 

Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln 
                405                 410                 415     

Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr Lys 
            420                 425                 430         

Ser Val Thr Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly 
        435                 440                 445             

Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala 
    450                 455                 460                 

Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala 
465                 470                 475                 480 

Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr 
                485                 490                 495     

Glu Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala 
            500                 505                 510         

Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys 
        515                 520                 525             

Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro 
    530                 535                 540                 

Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys Thr 
545                 550                 555                 560 

Leu Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu 
                565                 570                 575     

Arg Tyr Leu Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met 
            580                 585                 590         

Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln 
        595                 600                 605             

Val Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly 
    610                 615                 620                 

Ile Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu 
625                 630                 635                 640 

Met Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly 
                645                 650                 655     

Asn Asp Pro Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys 
            660                 665                 670         

Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly 
        675                 680                 685             

Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu 
    690                 695                 700                 

Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met 
705                 710                 715                 720 

Ala Leu Asn Lys Ser Val Val Asn Thr Asp Pro Gln Gly Tyr Pro Asn 
                725                 730                 735     

Arg Val Arg Gln Gln Arg Glu Lys Gly Ile Trp Val Tyr Glu Arg Tyr 
            740                 745                 750         

Pro Ala Val Asp Ser Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asp Thr 
        755                 760                 765             

Gly Lys Val Thr Trp Lys Tyr Gln Glu Glu Gly Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Asp Val Asp Gly Lys Gln 
785                 790                 795                 800 

Val Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu His Ser Thr Glu Glu 
                805                 810                 815     

Ser Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu 
            820                 825                 830         

Gln Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu 
        835                 840                 845             

Arg Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Arg Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys 
        915                 920                 925             

Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asn Ala Tyr Ser Glu 
945                 950                 955                 960 

Gly Thr Gln Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn 
                965                 970                 975     

Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser 
            980                 985                 990         

Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly 
        995                 1000                1005            

Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro 
    1010                1015                1020                

Gly Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser Leu 
1025                1030                1035                1040

Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly 
                1045                1050                1055    

Leu Trp Ala Pro Ala Gln Gln Glu Val Thr Ile Glu Ser Thr Ala Ser 
            1060                1065                1070        

Val Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg 
        1075                1080                1085            

Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr 
    1090                1095                1100                

Tyr Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly 
1105                1110                1115                1120

Gly Leu Ile Tyr Ile Lys Gly Asn Ser Pro Lys Asn Glu Ser Ala Glu 
                1125                1130                1135    

Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu 
            1140                1145                1150        

Trp Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser 
        1155                1160                1165            

Asp Ser Phe Val Tyr Thr Ala Pro Lys Asn Asn Leu Asn Ala Ser Asn 
    1170                1175                1180                

Tyr Ser Asn Tyr Thr Asp Gly Val Ala Glu Phe Ala Lys Glu Leu Asp 
1185                1190                1195                1200

Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Gly Glu Ser 
                1205                1210                1215    

Gly Asn His Arg Met Phe Thr Tyr Lys Ala Leu Thr Gly His Lys His 
            1220                1225                1230        

Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly 
        1235                1240                1245            

Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro 
    1250                1255                1260                

Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn 
1265                1270                1275                1280

Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn 
                1285                1290                1295    

Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn 
            1300                1305                1310        

Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser 
        1315                1320                1325            

Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met 
    1330                1335                1340                

Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln 
1345                1350                1355                1360

Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly 
                1365                1370                1375    

Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly 
            1380                1385                1390        

Asp Asp Val Ser Asn Asp Lys Phe Gly Gly Arg Asn Tyr Cys Ala Glu 
        1395                1400                1405            

Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val 
    1410                1415                1420                

Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala 
1425                1430                1435                1440

Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe Glu Gly Gly 
                1445                1450                1455    

Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ala Met His Leu Ser Lys 
            1460                1465                1470        

Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met 
        1475                1480                1485            

Pro Ala Glu 
    1490    

<210>   48
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   48
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn 
            20                  25                  30          

Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr 
65                  70                  75                  80  

Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala 
                85                  90                  95      

Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe 
            100                 105                 110         

Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp 
            180                 185                 190         

Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val 
                485                 490                 495     

Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln 
        515                 520                 525             

Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val 
    530                 535                 540                 

Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala 
545                 550                 555                 560 

Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln Pro Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr Gln Gln 
705                 710                 715                 720 

Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln 
                725                 730                 735     

Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile 
        755                 760                 765             

Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr His 
    770                 775                 780                 

Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro Val 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly Ser Lys 
        835                 840                 845             

Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu Gly Lys 
865                 870                 875                 880 

Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly Glu Ser 
                965                 970                 975     

Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Asp Val 
        995                 1000                1005            

Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly Glu Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
            1060                1065                1070        

Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
                1125                1130                1135    

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe 
                1285                1290                1295    

Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser 
            1300                1305                1310        

Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser 
            1380                1385                1390        

Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu 
        1395                1400                1405            

Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   49
<211>   1432
<212>   PRT
<213>   Escherichia coli

<400>   49
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Ile Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp 
            20                  25                  30          

Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp 
        35                  40                  45              

Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser 
    50                  55                  60                  

Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asp Lys Lys 
65                  70                  75                  80  

Ser Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn 
                85                  90                  95      

Thr Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg 
            100                 105                 110         

Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys 
        115                 120                 125             

Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala 
    130                 135                 140                 

Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr 
145                 150                 155                 160 

Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe 
                165                 170                 175     

Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val 
            180                 185                 190         

Asp Ser Met Gly Asn Gly Val Val Gly Val Asn Tyr Tyr Thr Ser Ser 
        195                 200                 205             

Gly Arg Gly Val Thr Gly Glu Asn Gly Lys Phe Asn Phe Ser Trp Gly 
    210                 215                 220                 

Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg 
225                 230                 235                 240 

Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg 
                245                 250                 255     

Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Gln Ala Gly Lys 
            260                 265                 270         

Asn Asp Glu Arg Glu Val Pro Asp Val Val Arg Lys Val Phe Ala Glu 
        275                 280                 285             

Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly 
    290                 295                 300                 

Glu Ala Leu Ser Glu Gly Asp Gln Thr Phe Glu Arg Thr Asn Glu Phe 
305                 310                 315                 320 

Leu Glu Gln Phe Glu Ser Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile 
                325                 330                 335     

Cys Asp Ser Leu Gly Gly Cys Asn Ser Gln Arg Trp Phe Ser Leu Thr 
            340                 345                 350         

Ala Arg Asn Val Asn Glu Gly Gln Ile Gln Gly Val Ile Asn Lys Leu 
        355                 360                 365             

Trp Gly Val Asp Lys Asp Tyr Lys Ser Val Thr Lys Phe His Val Phe 
    370                 375                 380                 

His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln 
385                 390                 395                 400 

Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg 
                405                 410                 415     

Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp 
            420                 425                 430         

Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro 
        435                 440                 445             

Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser 
    450                 455                 460                 

Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His 
465                 470                 475                 480 

Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Glu Gly Gly 
                485                 490                 495     

Val Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser Asp Ser Asn Asp Met 
            500                 505                 510         

Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp 
        515                 520                 525             

Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr 
    530                 535                 540                 

Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe 
545                 550                 555                 560 

Gly Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser 
                565                 570                 575     

Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly 
            580                 585                 590         

Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu 
        595                 600                 605             

Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp 
    610                 615                 620                 

Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn 
625                 630                 635                 640 

Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu 
                645                 650                 655     

Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn 
            660                 665                 670         

Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala Thr 
        675                 680                 685             

Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln Val 
705                 710                 715                 720 

Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu 
                725                 730                 735     

Glu Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Ala Lys Ile 
        755                 760                 765             

Phe Glu Lys Phe Pro Gly Leu Lys Glu Cys Lys Asp Pro Thr Tyr His 
    770                 775                 780                 

Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys 
        835                 840                 845             

Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys 
865                 870                 875                 880 

Asp Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys Ser Asp Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Glu Lys Ser Val Asn 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu 
                965                 970                 975     

Lys Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu 
        995                 1000                1005            

Val Thr Ile Glu Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Lys Val Thr Lys Thr Tyr Glu Leu Lys Ala Asn Gly Glu 
                1045                1050                1055    

Val Lys Phe Thr Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Pro Gln Asn Glu Ser Ala Glu Phe Thr Phe Thr Gly Val Val Lys 
        1075                1080                1085            

Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys Asn Ala Leu Asn Ser Pro 
    1090                1095                1100                

Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro 
1105                1110                1115                1120

Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe 
                1125                1130                1135    

Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly 
            1140                1145                1150        

Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu 
        1155                1160                1165            

Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly 
    1170                1175                1180                

Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn 
1185                1190                1195                1200

Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His 
                1205                1210                1215    

Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala 
            1220                1225                1230        

Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr 
        1235                1240                1245            

Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu 
    1250                1255                1260                

Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly 
1265                1270                1275                1280

Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn 
                1285                1290                1295    

Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly Asp Leu Pro Lys Phe Tyr 
            1300                1305                1310        

Ser Asp Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His 
        1315                1320                1325            

Arg Lys Ala Arg Gly Asp Glu Val Gly Lys Thr Lys Phe Gly Glu Arg 
    1330                1335                1340                

Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Lys Leu Met Leu 
1345                1350                1355                1360

Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys 
                1365                1370                1375    

Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met 
            1380                1385                1390        

Asn Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Glu Thr Leu Ala Ala 
        1395                1400                1405            

Leu Asn Leu Pro Lys Pro Gln Gln Gly Pro Glu Thr Ile Asn Gln Val 
    1410                1415                1420                

Thr Glu His Lys Met Ser Ala Glu 
1425                1430        

<210>   50
<211>   1432
<212>   PRT
<213>   Escherichia coli

<400>   50
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Ile Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp 
            20                  25                  30          

Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp 
        35                  40                  45              

Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser 
    50                  55                  60                  

Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asp Lys Lys 
65                  70                  75                  80  

Ser Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asp 
                85                  90                  95      

Thr Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg 
            100                 105                 110         

Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys 
        115                 120                 125             

Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala 
    130                 135                 140                 

Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr 
145                 150                 155                 160 

Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe 
                165                 170                 175     

Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val 
            180                 185                 190         

Asp Ser Met Gly Asn Gly Val Val Gly Val Asn Tyr Tyr Thr Ser Ser 
        195                 200                 205             

Gly Arg Gly Val Thr Gly Glu Asn Gly Lys Phe Asn Phe Ser Trp Gly 
    210                 215                 220                 

Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg 
225                 230                 235                 240 

Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg 
                245                 250                 255     

Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Gln Ala Gly Lys 
            260                 265                 270         

Asn Asp Glu Arg Glu Val Pro Asp Val Val Arg Lys Val Phe Ala Glu 
        275                 280                 285             

Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly 
    290                 295                 300                 

Glu Ala Leu Ser Glu Gly Asp Gln Thr Phe Glu Arg Thr Asn Glu Phe 
305                 310                 315                 320 

Leu Glu Gln Phe Glu Ser Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile 
                325                 330                 335     

Cys Asp Ser Leu Gly Gly Cys Asn Ser Gln Arg Trp Phe Ser Leu Thr 
            340                 345                 350         

Ala Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu 
        355                 360                 365             

Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe 
    370                 375                 380                 

His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln 
385                 390                 395                 400 

Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg 
                405                 410                 415     

Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp 
            420                 425                 430         

Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro 
        435                 440                 445             

Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser 
    450                 455                 460                 

Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His 
465                 470                 475                 480 

Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Glu Gly Gly 
                485                 490                 495     

Val Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser Asp Ser Asn Asp Met 
            500                 505                 510         

Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp 
        515                 520                 525             

Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr 
    530                 535                 540                 

Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe 
545                 550                 555                 560 

Gly Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser 
                565                 570                 575     

Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly 
            580                 585                 590         

Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu 
        595                 600                 605             

Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp 
    610                 615                 620                 

Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn 
625                 630                 635                 640 

Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu 
                645                 650                 655     

Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn 
            660                 665                 670         

Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala Thr 
        675                 680                 685             

Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln Val 
705                 710                 715                 720 

Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu 
                725                 730                 735     

Glu Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Ala Lys Ile 
        755                 760                 765             

Phe Glu Lys Phe Pro Gly Leu Lys Glu Cys Lys Asp Pro Thr Tyr His 
    770                 775                 780                 

Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys 
        835                 840                 845             

Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys 
865                 870                 875                 880 

Asp Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys Ser Asp Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Glu Lys Ser Val Asn 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu 
                965                 970                 975     

Lys Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu 
        995                 1000                1005            

Val Thr Ile Glu Ser Thr Ala Ser Val Ala Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Lys Val Thr Lys Thr Tyr Glu Leu Lys Ala Asn Gly Glu 
                1045                1050                1055    

Val Lys Phe Thr Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Pro Gln Asn Glu Ser Ala Glu Phe Thr Phe Thr Gly Val Val Lys 
        1075                1080                1085            

Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys Asn Ala Leu Asn Ser Pro 
    1090                1095                1100                

Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro 
1105                1110                1115                1120

Lys Lys Asn Leu Glu Ala Ser Asn Tyr Lys Gly Gly Gln Glu Gln Phe 
                1125                1130                1135    

Ala Glu Glu Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly 
            1140                1145                1150        

Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu 
        1155                1160                1165            

Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly 
    1170                1175                1180                

Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn 
1185                1190                1195                1200

Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His 
                1205                1210                1215    

Glu Ala Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala 
            1220                1225                1230        

Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr 
        1235                1240                1245            

Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu 
    1250                1255                1260                

Tyr Leu Glu Glu Ser Asn Asn Gln Ala Trp Ala Arg Gly Gly Ala Gly 
1265                1270                1275                1280

Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn 
                1285                1290                1295    

Phe Asp Ile Thr Lys Trp Tyr Pro Glu Gly Asn Leu Pro Lys Phe Tyr 
            1300                1305                1310        

Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His 
        1315                1320                1325            

Arg Lys Ala Arg Gly Asp Glu Val Gly Lys Thr Lys Phe Gly Glu Arg 
    1330                1335                1340                

Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu 
1345                1350                1355                1360

Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Ala Phe Phe Lys Lys 
                1365                1370                1375    

Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met 
            1380                1385                1390        

Asn Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Glu Thr Leu Ala Ala 
        1395                1400                1405            

Leu Asn Leu Pro Lys Pro Gln Gln Gly Pro Glu Thr Ile Asn Lys Val 
    1410                1415                1420                

Thr Glu Tyr Ser Met Pro Ala Glu 
1425                1430        

<210>   51
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   51
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Lys Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Asn Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val 
                485                 490                 495     

Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys 
            500                 505                 510         

Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Lys 
        515                 520                 525             

Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Asp 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln Val Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu 
                725                 730                 735     

Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe 
        755                 760                 765             

Ala Ala Phe Pro Gly Leu Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Asp Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys 
            900                 905                 910         

Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala 
        915                 920                 925             

Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu 
    930                 935                 940                 

Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val 
945                 950                 955                 960 

Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln Asn Val 
                965                 970                 975     

Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly 
            980                 985                 990         

Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr 
        995                 1000                1005            

Ile Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala Leu Ala 
    1010                1015                1020                

Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro 
1025                1030                1035                1040

Pro Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys 
                1045                1050                1055    

Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser 
            1060                1065                1070        

Thr Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro 
        1075                1080                1085            

Phe Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro 
    1090                1095                1100                

Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys 
1105                1110                1115                1120

Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn 
                1125                1130                1135    

Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe His Gly Arg Asp 
            1140                1145                1150        

Ser Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly 
        1155                1160                1165            

His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala 
    1170                1175                1180                

His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr 
1185                1190                1195                1200

Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val 
                1205                1210                1215    

Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu 
            1220                1225                1230        

Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly 
        1235                1240                1245            

Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu 
    1250                1255                1260                

Glu Glu Ser Asn Asn Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg 
1265                1270                1275                1280

Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp 
                1285                1290                1295    

Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser 
            1300                1305                1310        

Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser 
            1380                1385                1390        

Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu 
        1395                1400                1405            

Asp Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Gln Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   52
<211>   1433
<212>   PRT
<213>   Escherichia coli

<400>   52
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Leu Arg Val Thr Gly Asp 
1               5                   10                  15      

Ile Thr Cys Asn Asp Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly 
            20                  25                  30          

Asp Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe 
        35                  40                  45              

Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val 
    50                  55                  60                  

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asn Lys 
65                  70                  75                  80  

Lys Ser Asn Ala Leu Ser Leu Val Thr Ser Met Asn Ser Cys Pro Ala 
                85                  90                  95      

Asn Thr Glu Gln Val Cys Leu Glu Phe Ser Ser Val Ile Glu Ser Lys 
            100                 105                 110         

Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe 
        115                 120                 125             

Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
    130                 135                 140                 

Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly 
145                 150                 155                 160 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
                165                 170                 175     

Phe Tyr Gln Tyr Gln Pro Ser Glu Ile Ile Leu Ser Glu Gly Arg Leu 
            180                 185                 190         

Val Asp Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn 
        195                 200                 205             

Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp 
    210                 215                 220                 

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
225                 230                 235                 240 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
                245                 250                 255     

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
            260                 265                 270         

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
        275                 280                 285             

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
    290                 295                 300                 

Gly Ala Thr Leu Asp Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu 
305                 310                 315                 320 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
                325                 330                 335     

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
            340                 345                 350         

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
        355                 360                 365             

Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val 
    370                 375                 380                 

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
385                 390                 395                 400 

Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala 
                405                 410                 415     

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
            420                 425                 430         

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu 
        435                 440                 445             

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
    450                 455                 460                 

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
465                 470                 475                 480 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly 
                485                 490                 495     

Gly Val Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp 
            500                 505                 510         

Met Lys Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys 
        515                 520                 525             

Trp Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp 
    530                 535                 540                 

Thr Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Ala 
545                 550                 555                 560 

Phe Asp Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser 
                565                 570                 575     

Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn 
            580                 585                 590         

Gly Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro 
        595                 600                 605             

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
    610                 615                 620                 

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
625                 630                 635                 640 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg 
                645                 650                 655     

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
            660                 665                 670         

Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala 
        675                 680                 685             

Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln 
705                 710                 715                 720 

Val Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Leu Glu Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Glu Lys 
        755                 760                 765             

Ile Phe Ala Ala Phe Pro Gly Leu Lys Glu Cys Thr Asn Pro Ala Tyr 
    770                 775                 780                 

His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg 
        835                 840                 845             

Lys Gly Glu Arg Leu Ser Cys Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Asp Thr Ser Tyr Arg Tyr Glu Glu Gly 
865                 870                 875                 880 

Lys Asn Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu 
            900                 905                 910         

Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln 
                965                 970                 975     

Asn Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu 
        995                 1000                1005            

Val Thr Ile Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr 
                1045                1050                1055    

Val Lys Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Ser Thr Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys 
        1075                1080                1085            

Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro 
    1090                1095                1100                

Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro 
1105                1110                1115                1120

Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe 
                1125                1130                1135    

Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly 
            1140                1145                1150        

Arg Asp Ser Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu 
        1155                1160                1165            

Pro Gly His Lys His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly 
    1170                1175                1180                

Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn 
1185                1190                1195                1200

Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His 
                1205                1210                1215    

Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala 
            1220                1225                1230        

Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr 
        1235                1240                1245            

Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu 
    1250                1255                1260                

Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly 
1265                1270                1275                1280

Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn 
                1285                1290                1295    

Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe 
            1300                1305                1310        

Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met 
        1315                1320                1325            

His Arg Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly 
    1330                1335                1340                

Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met 
1345                1350                1355                1360

Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys 
                1365                1370                1375    

Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu 
            1380                1385                1390        

Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala 
        1395                1400                1405            

Ser Leu Lys Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Lys 
    1410                1415                1420                

Val Thr Glu His Lys Met Ser Val Glu 
1425                1430            

<210>   53
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   53
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Leu Arg Val Thr Gly Asp 
1               5                   10                  15      

Ile Thr Cys Asn Asp Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly 
            20                  25                  30          

Asp Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe 
        35                  40                  45              

Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val 
    50                  55                  60                  

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asn Lys 
65                  70                  75                  80  

Lys Ser Asn Ala Leu Ser Leu Val Thr Ser Met Asn Ser Cys Pro Ala 
                85                  90                  95      

Asn Thr Glu Gln Val Cys Leu Glu Phe Ser Ser Val Ile Glu Ser Lys 
            100                 105                 110         

Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe 
        115                 120                 125             

Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
    130                 135                 140                 

Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly 
145                 150                 155                 160 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
                165                 170                 175     

Phe Tyr Gln Tyr Gln Pro Ser Glu Ile Ile Leu Ser Glu Gly Arg Leu 
            180                 185                 190         

Val Asp Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn 
        195                 200                 205             

Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp 
    210                 215                 220                 

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
225                 230                 235                 240 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
                245                 250                 255     

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
            260                 265                 270         

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
        275                 280                 285             

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
    290                 295                 300                 

Gly Ala Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu 
305                 310                 315                 320 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
                325                 330                 335     

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
            340                 345                 350         

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
        355                 360                 365             

Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val 
    370                 375                 380                 

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
385                 390                 395                 400 

Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala 
                405                 410                 415     

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
            420                 425                 430         

Asp Lys Asn Asp Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg 
        435                 440                 445             

Pro Glu Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile 
    450                 455                 460                 

Ser Leu Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro 
465                 470                 475                 480 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly 
                485                 490                 495     

Gly Val Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp 
            500                 505                 510         

Met Lys Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asn Asp Arg 
        515                 520                 525             

Trp Leu Pro Asp Ala Lys Ser Ser Met Thr Val Gly Thr Asn Leu Asp 
    530                 535                 540                 

Thr Val Tyr Phe Lys Lys His Gly Gln Val Leu Gly Asn Ser Ala Pro 
545                 550                 555                 560 

Phe Ala Phe His Lys Asp Phe Thr Gly Ile Thr Val Lys Pro Met Thr 
                565                 570                 575     

Ser Tyr Gly Asn Leu Asn Pro Asp Glu Val Pro Leu Leu Ile Leu Asn 
            580                 585                 590         

Gly Phe Glu Tyr Val Thr Gln Trp Gly Ser Asp Pro Tyr Ser Ile Pro 
        595                 600                 605             

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
    610                 615                 620                 

Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
625                 630                 635                 640 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg 
                645                 650                 655     

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
            660                 665                 670         

Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ser 
        675                 680                 685             

Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln 
705                 710                 715                 720 

Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Gln Glu Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Gln Arg 
        755                 760                 765             

Ile Leu Asp Ala Phe Pro Gly Leu Glu Val Cys Lys Asp Ser Asp Tyr 
    770                 775                 780                 

His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Ser Gly Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Asp Leu Gly 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Leu Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg 
        835                 840                 845             

Gln Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Glu Thr Lys Tyr Arg Tyr Glu Glu Gly 
865                 870                 875                 880 

Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Thr Asn Asn Ala Tyr Val Gly Thr Gln Cys Ser Ala Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Glu Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln Asn 
                965                 970                 975     

Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val 
        995                 1000                1005            

Thr Ile Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val 
                1045                1050                1055    

Lys Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser 
            1060                1065                1070        

Ser Thr Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala 
                1125                1130                1135    

Asn Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asp Ser Glu Ser Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe 
                1285                1290                1295    

Asp Ile Lys Lys Trp Tyr Pro Glu Gly Glu Leu Pro Lys Phe Phe Ser 
            1300                1305                1310        

Asp Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Asp Val Gly Asn Lys Thr Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Ser Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Ala Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser 
            1380                1385                1390        

Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Ser Thr Leu Ala Ser Leu 
        1395                1400                1405            

Lys Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Lys Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Leu Glu 
1425                1430    

<210>   54
<211>   1432
<212>   PRT
<213>   Escherichia coli

<400>   54
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Leu Arg Val Thr Gly Asp 
1               5                   10                  15      

Ile Thr Cys Asn Asp Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly 
            20                  25                  30          

Asp Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe 
        35                  40                  45              

Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val 
    50                  55                  60                  

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asn Lys 
65                  70                  75                  80  

Lys Ser Asn Ala Leu Ser Leu Val Thr Ser Met Asn Ser Cys Pro Ala 
                85                  90                  95      

Asn Thr Glu Gln Val Cys Leu Glu Phe Ser Ser Val Ile Glu Ser Lys 
            100                 105                 110         

Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe 
        115                 120                 125             

Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
    130                 135                 140                 

Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly 
145                 150                 155                 160 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
                165                 170                 175     

Phe Tyr Gln Tyr Gln Pro Ser Glu Ile Ile Leu Ser Glu Gly Arg Leu 
            180                 185                 190         

Val Asp Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn 
        195                 200                 205             

Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp 
    210                 215                 220                 

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
225                 230                 235                 240 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
                245                 250                 255     

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly 
            260                 265                 270         

Gln Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala 
        275                 280                 285             

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
    290                 295                 300                 

Gly Ala Thr Leu Asp Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu 
305                 310                 315                 320 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
                325                 330                 335     

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
            340                 345                 350         

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
        355                 360                 365             

Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val 
    370                 375                 380                 

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
385                 390                 395                 400 

Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala 
                405                 410                 415     

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
            420                 425                 430         

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu 
        435                 440                 445             

Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile 
    450                 455                 460                 

Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro 
465                 470                 475                 480 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly 
                485                 490                 495     

Gly Val Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp 
            500                 505                 510         

Met Lys Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys 
        515                 520                 525             

Trp Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp 
    530                 535                 540                 

Thr Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Ala 
545                 550                 555                 560 

Phe Asp Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser 
                565                 570                 575     

Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn 
            580                 585                 590         

Gly Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro 
        595                 600                 605             

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
    610                 615                 620                 

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
625                 630                 635                 640 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg 
                645                 650                 655     

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
            660                 665                 670         

Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala 
        675                 680                 685             

Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln 
705                 710                 715                 720 

Val Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Leu Glu Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Glu Lys 
        755                 760                 765             

Ile Phe Ala Ala Phe Pro Gly Leu Lys Glu Cys Thr Asn Pro Ala Tyr 
    770                 775                 780                 

His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg 
        835                 840                 845             

Lys Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Asp Thr Ser Tyr Arg Tyr Glu Glu Gly 
865                 870                 875                 880 

Lys Asn Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu 
            900                 905                 910         

Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln 
                965                 970                 975     

Asn Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu 
        995                 1000                1005            

Val Thr Ile Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr 
                1045                1050                1055    

Val Lys Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Ser Thr Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys 
        1075                1080                1085            

Ala Pro Phe Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro 
    1090                1095                1100                

Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro 
1105                1110                1115                1120

Lys Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe 
                1125                1130                1135    

Ala Asn Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly 
            1140                1145                1150        

Arg Asp Glu Thr Ser Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu 
        1155                1160                1165            

Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly 
    1170                1175                1180                

Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn 
1185                1190                1195                1200

Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His 
                1205                1210                1215    

Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala 
            1220                1225                1230        

Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr 
        1235                1240                1245            

Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu 
    1250                1255                1260                

Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly 
1265                1270                1275                1280

Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn 
                1285                1290                1295    

Phe Asp Ile Lys Lys Trp Tyr Pro Glu Gly Glu Leu Pro Lys Phe Phe 
            1300                1305                1310        

Ser Asp Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His 
        1315                1320                1325            

Arg Lys Ala Arg Gly Asp Asp Val Gly Asp Lys Thr Phe Gly Gly Lys 
    1330                1335                1340                

Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu 
1345                1350                1355                1360

Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Ala Phe Phe Lys Lys 
                1365                1370                1375    

Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met 
            1380                1385                1390        

Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Ser Thr Leu Ala Ser 
        1395                1400                1405            

Leu Lys Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Lys Val 
    1410                1415                1420                

Thr Glu His Lys Met Ser Leu Glu 
1425                1430        

<210>   55
<211>   1432
<212>   PRT
<213>   Escherichia coli

<400>   55
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Leu Arg Val Thr Gly Asp 
1               5                   10                  15      

Ile Thr Cys Asn Asp Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly 
            20                  25                  30          

Asp Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe 
        35                  40                  45              

Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val 
    50                  55                  60                  

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asn Lys 
65                  70                  75                  80  

Lys Ser Asn Ala Leu Ser Leu Val Thr Ser Met Asn Ser Cys Pro Ala 
                85                  90                  95      

Asn Thr Glu Gln Val Cys Leu Glu Phe Ser Ser Val Ile Glu Ser Lys 
            100                 105                 110         

Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe 
        115                 120                 125             

Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
    130                 135                 140                 

Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Ala Thr Thr Pro Gly 
145                 150                 155                 160 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
                165                 170                 175     

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu 
            180                 185                 190         

Val Asp Ser Gln Gly Asp Gly Val Val Gly Val Asn Tyr Tyr Thr Asn 
        195                 200                 205             

Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp 
    210                 215                 220                 

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
225                 230                 235                 240 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
                245                 250                 255     

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Lys Ala Gly 
            260                 265                 270         

Gln Asn His Thr Arg Val Val Pro Asp Glu Val Arg Lys Val Phe Ala 
        275                 280                 285             

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
    290                 295                 300                 

Gly Ala Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu 
305                 310                 315                 320 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
                325                 330                 335     

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
            340                 345                 350         

Thr Thr Arg Asn Val Asn Asp Gly Lys Ile Gln Gly Val Ile Asn Lys 
        355                 360                 365             

Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val 
    370                 375                 380                 

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
385                 390                 395                 400 

Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala 
                405                 410                 415     

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
            420                 425                 430         

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg 
        435                 440                 445             

Pro Glu Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile 
    450                 455                 460                 

Ser Leu Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro 
465                 470                 475                 480 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly 
                485                 490                 495     

Gly Val Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp 
            500                 505                 510         

Met Lys Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys 
        515                 520                 525             

Trp Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp 
    530                 535                 540                 

Thr Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Ala 
545                 550                 555                 560 

Phe Asp Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser 
                565                 570                 575     

Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn 
            580                 585                 590         

Gly Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro 
        595                 600                 605             

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
    610                 615                 620                 

Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
625                 630                 635                 640 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg 
                645                 650                 655     

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
            660                 665                 670         

Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Arg Arg Ser 
        675                 680                 685             

Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln 
705                 710                 715                 720 

Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Gln Glu Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Gln Arg 
        755                 760                 765             

Ile Leu Asp Ala Phe Pro Gly Leu Glu Val Cys Lys Asp Ser Asp Tyr 
    770                 775                 780                 

His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Asp Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Asp Leu Ser 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Leu Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg 
        835                 840                 845             

Gln Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Glu Thr Lys Tyr Arg Tyr Glu Glu Gly 
865                 870                 875                 880 

Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Thr Asn Asn Ala Tyr Val Gly Thr Gln Cys Ser Ala Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Glu Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Val Val Asn Thr Asn Gly Glu Thr 
                965                 970                 975     

Val Thr Gln Asn Ile Asn Leu Tyr Ser Ala Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu Val 
        995                 1000                1005            

Ser Ile Glu Ser Lys Ala Thr Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ser Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
            1060                1065                1070        

Lys Glu Val Gln Ser Ala Asp Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Lys Trp Gln His Asp Leu Asn Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala 
                1125                1130                1135    

Asn Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asp Ser Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Pro 
        1155                1160                1165            

Gly His Lys His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe 
                1285                1290                1295    

Asp Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr 
            1300                1305                1310        

Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His 
        1315                1320                1325            

Arg Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Lys 
    1330                1335                1340                

Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu 
1345                1350                1355                1360

Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys 
                1365                1370                1375    

Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met 
            1380                1385                1390        

Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser 
        1395                1400                1405            

Leu Lys Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Lys Val 
    1410                1415                1420                

Thr Glu His Lys Met Ser Val Glu 
1425                1430        

<210>   56
<211>   1429
<212>   PRT
<213>   Escherichia coli

<400>   56
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn 
            20                  25                  30          

Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr 
65                  70                  75                  80  

Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala 
                85                  90                  95      

Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe 
            100                 105                 110         

Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp 
            180                 185                 190         

Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asn Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val 
                485                 490                 495     

Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln 
        515                 520                 525             

Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val 
    530                 535                 540                 

Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala 
545                 550                 555                 560 

Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Gln Arg Glu Lys Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Phe Val Asp Gly Lys Pro Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Glu Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Asp 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu 
                725                 730                 735     

Asp Val Asp Gly Lys Gln Val Lys Arg Tyr Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Glu His Glu Thr Asn Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile Ile 
        755                 760                 765             

Lys Ala Phe Pro Gly Leu Glu Glu Cys Lys Asp Pro Thr Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Asn Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Ser Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Glu Ile Glu Tyr Ser Tyr Asp Ser Ser Lys Glu 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asp Ala Tyr Thr Lys Gly Thr Leu Cys Ser Ala Glu Leu Lys Gln 
            900                 905                 910         

Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Gly Ser Lys Ala Gly 
        915                 920                 925             

Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr 
    930                 935                 940                 

Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp 
945                 950                 955                 960 

Val Glu Lys Tyr Pro Gly Ala Val Ser Val Gly Gly Glu Glu Val Thr 
                965                 970                 975     

Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn 
            980                 985                 990         

Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr Ile 
        995                 1000                1005            

Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala Leu Ala Asp 
    1010                1015                1020                

Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro 
1025                1030                1035                1040

Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe 
                1045                1050                1055    

Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser Thr 
            1060                1065                1070        

Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe 
        1075                1080                1085            

Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro Leu 
    1090                1095                1100                

Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn 
1105                1110                1115                1120

Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Asp Gln Phe Ala Lys Asp 
                1125                1130                1135    

Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp 
            1140                1145                1150        

Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr Gly His 
        1155                1160                1165            

Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His 
    1170                1175                1180                

Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr 
1185                1190                1195                1200

Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly 
                1205                1210                1215    

His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr Glu Val 
            1220                1225                1230        

Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys 
        1235                1240                1245            

Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp 
    1250                1255                1260                

Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu 
1265                1270                1275                1280

Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile 
                1285                1290                1295    

Thr Lys Trp Tyr Pro Asp Gly Lys Leu Pro Ala Phe Tyr Ser Glu Arg 
            1300                1305                1310        

Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala 
        1315                1320                1325            

Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys 
    1330                1335                1340                

Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser 
1345                1350                1355                1360

Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro 
                1365                1370                1375    

Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ala Glu Met Ser Phe Glu 
            1380                1385                1390        

Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu Asn Leu 
        1395                1400                1405            

Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr Glu His 
    1410                1415                1420                

Lys Met Ser Ala Glu 
1425                

<210>   57
<211>   1430
<212>   PRT
<213>   Escherichia coli

<400>   57
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Lys Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Ala Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Asn Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Glu Thr Ala Ser Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val 
                485                 490                 495     

Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys 
            500                 505                 510         

Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu 
        515                 520                 525             

Pro Asp Ala Lys Ser Ser Met Thr Val Gly Thr Asn Leu Glu Thr Val 
    530                 535                 540                 

Tyr Phe Lys Lys His Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala 
545                 550                 555                 560 

Phe His Lys Asp Phe Thr Gly Ile Thr Val Lys Pro Met Thr Ser Tyr 
                565                 570                 575     

Gly Asn Leu Asn Pro Asp Glu Val Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Trp Gly Ser Asp Pro Tyr Ser Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ser Thr Pro 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu 
                725                 730                 735     

Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu 
        755                 760                 765             

Asp Ala Phe Pro Gly Leu Glu Val Cys Lys Asp Ser Asp Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Asp Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Asp Leu Ser Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Leu Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Gln Gly 
        835                 840                 845             

Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Glu Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr 
                885                 890                 895     

Asn Asn Ala Tyr Val Gly Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser 
            900                 905                 910         

Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly 
        915                 920                 925             

Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr 
    930                 935                 940                 

Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp 
945                 950                 955                 960 

Val Glu Lys Tyr Pro Gly Val Val Asn Thr Asn Gly Glu Thr Val Thr 
                965                 970                 975     

Gln Asn Ile Asn Leu Tyr Ser Ala Pro Thr Lys Trp Phe Ala Gly Asn 
            980                 985                 990         

Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu Val Ser Ile 
        995                 1000                1005            

Glu Ser Lys Ser Thr Val Pro Val Thr Val Thr Val Ala Leu Ala Asp 
    1010                1015                1020                

Asp Leu Thr Gly Arg Glu Lys His Glu Val Ser Leu Asn Arg Pro Pro 
1025                1030                1035                1040

Arg Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val Thr Phe 
                1045                1050                1055    

Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser Lys Glu 
            1060                1065                1070        

Val Gln Ser Ala Asp Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe 
        1075                1080                1085            

Tyr Lys Asp Gly Lys Trp Gln His Asp Leu Asn Ser Pro Ala Pro Leu 
    1090                1095                1100                

Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn 
1105                1110                1115                1120

Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp 
                1125                1130                1135    

Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser 
            1140                1145                1150        

Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly His 
        1155                1160                1165            

Lys His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His 
    1170                1175                1180                

Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr 
1185                1190                1195                1200

Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly 
                1205                1210                1215    

His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val 
            1220                1225                1230        

Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys 
        1235                1240                1245            

Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu 
    1250                1255                1260                

Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu 
1265                1270                1275                1280

Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile 
                1285                1290                1295    

Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu 
            1300                1305                1310        

Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys 
        1315                1320                1325            

Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr 
    1330                1335                1340                

Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala 
1345                1350                1355                1360

Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn 
                1365                1370                1375    

Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser Phe 
            1380                1385                1390        

Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp 
        1395                1400                1405            

Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Gln Val Thr Glu 
    1410                1415                1420                

His Lys Met Ser Ala Glu 
1425                1430

<210>   58
<211>   1434
<212>   PRT
<213>   Escherichia coli

<400>   58
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Ile Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp 
            20                  25                  30          

Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp 
        35                  40                  45              

Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser 
    50                  55                  60                  

Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asp Lys Lys 
65                  70                  75                  80  

Ser Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn 
                85                  90                  95      

Thr Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg 
            100                 105                 110         

Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys 
        115                 120                 125             

Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala 
    130                 135                 140                 

Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr 
145                 150                 155                 160 

Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe 
                165                 170                 175     

Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val 
            180                 185                 190         

Asp Ser Met Gly Asn Gly Val Val Gly Val Asn Tyr Tyr Thr Ser Ser 
        195                 200                 205             

Gly Arg Gly Val Thr Gly Glu Asn Gly Lys Phe Asn Phe Ser Trp Gly 
    210                 215                 220                 

Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg 
225                 230                 235                 240 

Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg 
                245                 250                 255     

Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Gln Ala Gly Lys 
            260                 265                 270         

Asn Asp Glu Arg Glu Val Pro Asp Val Val Arg Lys Val Phe Ala Ala 
        275                 280                 285             

Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly 
    290                 295                 300                 

Glu Ala Leu Ser Glu Gly Asp Gln Thr Phe Glu Arg Thr Asn Glu Phe 
305                 310                 315                 320 

Leu Glu Gln Phe Glu Ser Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile 
                325                 330                 335     

Cys Asp Ser Leu Gly Gly Cys Asn Ser Gln Arg Trp Phe Ser Leu Thr 
            340                 345                 350         

Ala Arg Asn Val Asn Glu Gly Gln Ile Gln Gly Val Ile Asn Lys Leu 
        355                 360                 365             

Trp Gly Val Asp Lys Asp Tyr Lys Ser Val Thr Lys Phe His Val Phe 
    370                 375                 380                 

His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln 
385                 390                 395                 400 

Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg 
                405                 410                 415     

Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp 
            420                 425                 430         

Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro 
        435                 440                 445             

Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser 
    450                 455                 460                 

Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His 
465                 470                 475                 480 

Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Glu Gly Gly 
                485                 490                 495     

Val Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser Asp Ser Asn Asp Met 
            500                 505                 510         

Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Lys Trp 
        515                 520                 525             

Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr 
    530                 535                 540                 

Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe 
545                 550                 555                 560 

Gly Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser 
                565                 570                 575     

Tyr Gly Asp Leu Asp Pro Gln Lys Met Pro Leu Leu Ile Leu Asn Gly 
            580                 585                 590         

Phe Glu Tyr Val Thr Gln Val Gly Gly Asp Pro Tyr Ala Val Pro Leu 
        595                 600                 605             

Arg Ala Asp Thr Ser Lys Pro Lys Leu Ser Gln Gln Asp Val Thr Asp 
    610                 615                 620                 

Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn 
625                 630                 635                 640 

Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu 
                645                 650                 655     

Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn 
            660                 665                 670         

Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr 
        675                 680                 685             

Gly Ile Trp Val Tyr Glu Arg Tyr Pro Val Val Glu Gly Glu Leu Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Ser Lys Thr Gly Lys Val Thr Trp Lys Tyr Gln Ile 
705                 710                 715                 720 

Asp Asn Lys Pro Asp Lys Lys Pro Lys Leu Glu Val Ala Ser Trp Gln 
                725                 730                 735     

Glu Glu Val Asp Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Asp His Lys Thr Thr Glu Ser Leu Asp Ala Ala Lys Lys Lys Ile 
        755                 760                 765             

Leu Glu Lys Phe Lys Gly Leu Glu Glu Cys Lys Asp Ser Thr Tyr His 
    770                 775                 780                 

Tyr Glu Ile Asn Cys Leu Glu Tyr Arg Pro Gly Thr Asn Val Pro Ala 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Ser Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys 
        835                 840                 845             

Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Glu Ile Glu Tyr Ser Tyr Asp Ser Ser Lys 
865                 870                 875                 880 

Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys Ser Asp Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Glu Lys Ser Val Asn 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln 
                965                 970                 975     

Glu Val Thr Glu Ser Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu 
        995                 1000                1005            

Val Thr Ile Lys Ser Asn Ala Asp Val Pro Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Lys Val Thr Lys Thr Tyr Glu Leu Lys Ala Asn Gly Glu 
                1045                1050                1055    

Val Lys Phe Thr Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Lys Glu Asn Asn Lys Ser Ala Ser Phe Thr Phe Thr Gly Val Val 
        1075                1080                1085            

Lys Ala Pro Phe Tyr Lys Asn Gly Ala Trp Lys Asn Ala Leu Asn Ser 
    1090                1095                1100                

Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr 
1105                1110                1115                1120

Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu 
                1125                1130                1135    

Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr 
            1140                1145                1150        

Gly Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn 
        1155                1160                1165            

Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile 
    1170                1175                1180                

Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr 
1185                1190                1195                1200

Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp 
                1205                1210                1215    

His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly 
            1220                1225                1230        

Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg 
        1235                1240                1245            

Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro 
    1250                1255                1260                

Glu Tyr Leu Glu Glu Ser Asn Asn Gln Ala Trp Ala Arg Gly Gly Ala 
1265                1270                1275                1280

Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys 
                1285                1290                1295    

Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu 
            1300                1305                1310        

Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu 
        1315                1320                1325            

Met His Arg Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly 
    1330                1335                1340                

Gly Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Thr Ala Asp Thr Leu 
1345                1350                1355                1360

Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe 
                1365                1370                1375    

Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr 
            1380                1385                1390        

Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu 
        1395                1400                1405            

Ala Ser Leu Asp Leu Pro Lys Pro Lys Gln Gly Pro Glu Thr Ile Asn 
    1410                1415                1420                

Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
1425                1430                

<210>   59
<211>   1429
<212>   PRT
<213>   Escherichia coli

<400>   59
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Lys Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Asn Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val 
                485                 490                 495     

Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys 
            500                 505                 510         

Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu 
        515                 520                 525             

Pro Asp Ala Lys Ser Asn Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Lys His Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Gly 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ser Thr Pro 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu 
                725                 730                 735     

Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Lys Arg Ile Leu 
        755                 760                 765             

Asp Ala Phe Pro Gly Leu Glu Glu Cys Lys Asp Ser Asp Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asn Ala Tyr Asp Gly Gly Thr Gln Cys Ser Ala Glu Leu Lys Gln 
            900                 905                 910         

Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Gly Ser Lys Ala Gly 
        915                 920                 925             

Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr 
    930                 935                 940                 

Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp 
945                 950                 955                 960 

Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu Glu Val Thr 
                965                 970                 975     

Glu Thr Ile Asn Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn 
            980                 985                 990         

Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu Val Ser Ile 
        995                 1000                1005            

Lys Ser Asn Ala Lys Val Pro Val Thr Val Thr Val Ala Leu Ala Asp 
    1010                1015                1020                

Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro 
1025                1030                1035                1040

Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe 
                1045                1050                1055    

Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Ser Asp Ser Lys Glu 
            1060                1065                1070        

Glu Lys Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe 
        1075                1080                1085            

Tyr Lys Asp Gly Lys Trp Lys Asn Asp Leu Lys Ser Pro Ala Pro Leu 
    1090                1095                1100                

Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn 
1105                1110                1115                1120

Leu Glu Ala Ser Asn Tyr Lys Gly Gly Leu Lys Gln Phe Ala Glu Asp 
                1125                1130                1135    

Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Gly 
            1140                1145                1150        

Glu Ser Gly Lys His Arg Met Phe Thr Tyr Glu Ala Leu Thr Gly His 
        1155                1160                1165            

Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His 
    1170                1175                1180                

Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr 
1185                1190                1195                1200

Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly 
                1205                1210                1215    

His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val 
            1220                1225                1230        

Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys 
        1235                1240                1245            

Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu 
    1250                1255                1260                

Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu 
1265                1270                1275                1280

Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile 
                1285                1290                1295    

Lys Gln Trp Tyr Pro Glu Gly Ser Leu Pro Ala Phe Tyr Ser Glu Arg 
            1300                1305                1310        

Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala 
        1315                1320                1325            

Arg Gly Asp Asp Val Gly Asn Asp Lys Phe Gly Asn Arg Asn Tyr Cys 
    1330                1335                1340                

Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser 
1345                1350                1355                1360

Trp Val Ala Gln Thr Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro 
                1365                1370                1375    

Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu 
            1380                1385                1390        

Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu 
        1395                1400                1405            

Pro Lys Pro Lys Gln Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr 
    1410                1415                1420                

Ser Met Pro Ala Glu 
1425                

<210>   60
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   60
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Lys Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Asn Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val 
                485                 490                 495     

Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys 
            500                 505                 510         

Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Lys 
        515                 520                 525             

Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Asp 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln Val Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu 
                725                 730                 735     

Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Glu Lys Ile Phe 
        755                 760                 765             

Ala Ala Phe Pro Gly Leu Lys Glu Cys Thr Asn Pro Ala Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Asp Thr Ser Tyr Arg Tyr Glu Glu Gly Lys Asn 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys Lys 
            900                 905                 910         

Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys Ala 
        915                 920                 925             

Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu 
    930                 935                 940                 

Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val 
945                 950                 955                 960 

Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Glu Glu Gly Gln Asn Val 
                965                 970                 975     

Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly 
            980                 985                 990         

Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val Thr 
        995                 1000                1005            

Ile Lys Ser Asn Ala Asn Val Pro Val Thr Val Thr Val Ala Leu Ala 
    1010                1015                1020                

Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro 
1025                1030                1035                1040

Pro Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys 
                1045                1050                1055    

Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser Ser 
            1060                1065                1070        

Thr Asn Glu Ser Ala Ser Phe Thr Phe Thr Gly Val Val Lys Ala Pro 
        1075                1080                1085            

Phe Tyr Lys Asp Gly Ala Trp Lys Asn Asp Leu Asn Ser Pro Ala Pro 
    1090                1095                1100                

Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys Lys 
1105                1110                1115                1120

Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala Asn 
                1125                1130                1135    

Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp 
            1140                1145                1150        

Ser Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Pro Gly 
        1155                1160                1165            

His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala 
    1170                1175                1180                

His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr 
1185                1190                1195                1200

Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val 
                1205                1210                1215    

Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu 
            1220                1225                1230        

Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly 
        1235                1240                1245            

Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu 
    1250                1255                1260                

Glu Glu Ser Asn Asn Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg 
1265                1270                1275                1280

Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp 
                1285                1290                1295    

Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr Ser 
            1300                1305                1310        

Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Ser 
            1380                1385                1390        

Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu 
        1395                1400                1405            

Asp Leu Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Gln Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   61
<211>   1429
<212>   PRT
<213>   Escherichia coli

<400>   61
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Lys Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Glu Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Asn Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val 
                485                 490                 495     

Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp Met Lys 
            500                 505                 510         

Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu 
        515                 520                 525             

Pro Asp Ala Lys Ser Asn Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Lys His Gly Gln Val Thr Gly Asn Ser Ala Ala Phe Gly 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ser Thr Pro 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu 
                725                 730                 735     

Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Lys Arg Ile Leu 
        755                 760                 765             

Asp Ala Phe Pro Gly Leu Glu Glu Cys Lys Asp Ser Asp Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asn Ala Tyr Asp Gly Gly Thr Gln Cys Ser Ala Glu Leu Lys Gln 
            900                 905                 910         

Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Gly Ser Lys Ala Gly 
        915                 920                 925             

Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr 
    930                 935                 940                 

Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys Val Asp 
945                 950                 955                 960 

Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu Glu Val Thr 
                965                 970                 975     

Glu Thr Ile Asn Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn 
            980                 985                 990         

Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu Val Ser Ile 
        995                 1000                1005            

Lys Ser Asn Ala Lys Val Pro Val Thr Val Thr Val Ala Leu Ala Asp 
    1010                1015                1020                

Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg Pro Pro 
1025                1030                1035                1040

Arg Val Thr Lys Thr Tyr Ser Leu Asp Ala Ser Gly Thr Val Lys Phe 
                1045                1050                1055    

Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Ser Asp Ser Lys Glu 
            1060                1065                1070        

Glu Lys Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala Pro Phe 
        1075                1080                1085            

Tyr Lys Asp Gly Lys Trp Lys Asn Asp Leu Lys Ser Pro Ala Pro Leu 
    1090                1095                1100                

Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn 
1105                1110                1115                1120

Leu Glu Ala Ser Asn Tyr Lys Gly Gly Leu Lys Gln Phe Ala Glu Asp 
                1125                1130                1135    

Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg Asp Gly 
            1140                1145                1150        

Glu Ser Gly Lys His Arg Met Phe Thr Tyr Glu Ala Leu Thr Gly His 
        1155                1160                1165            

Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp Ala His 
    1170                1175                1180                

Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr 
1185                1190                1195                1200

Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu Val Gly 
                1205                1210                1215    

His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr Glu Val 
            1220                1225                1230        

Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys 
        1235                1240                1245            

Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu 
    1250                1255                1260                

Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu 
1265                1270                1275                1280

Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile 
                1285                1290                1295    

Lys Gln Trp Tyr Pro Glu Gly Ser Leu Pro Ala Phe Tyr Ser Glu Arg 
            1300                1305                1310        

Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala 
        1315                1320                1325            

Arg Gly Asp Asp Val Gly Asn Asp Lys Phe Gly Asn Arg Asn Tyr Cys 
    1330                1335                1340                

Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser 
1345                1350                1355                1360

Trp Val Ala Gln Thr Asp Leu Ser Ala Phe Phe Lys Lys Trp Asn Pro 
                1365                1370                1375    

Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu 
            1380                1385                1390        

Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asp Leu 
        1395                1400                1405            

Pro Lys Pro Glu Gln Gly Pro Glu Thr Ile Asn Gln Val Thr Glu His 
    1410                1415                1420                

Lys Met Ser Ala Glu 
1425                

<210>   62
<211>   1435
<212>   PRT
<213>   Escherichia coli

<400>   62
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Ile Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asp 
            20                  25                  30          

Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe Asp 
        35                  40                  45              

Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser 
    50                  55                  60                  

Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asp Lys Lys 
65                  70                  75                  80  

Ser Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asp 
                85                  90                  95      

Thr Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg 
            100                 105                 110         

Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys 
        115                 120                 125             

Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala 
    130                 135                 140                 

Pro Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr 
145                 150                 155                 160 

Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe 
                165                 170                 175     

Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val 
            180                 185                 190         

Asp Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser 
        195                 200                 205             

Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly 
    210                 215                 220                 

Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg 
225                 230                 235                 240 

Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg 
                245                 250                 255     

Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln 
            260                 265                 270         

Asn Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu 
        275                 280                 285             

Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly 
    290                 295                 300                 

Ala Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe 
305                 310                 315                 320 

Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile 
                325                 330                 335     

Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr 
            340                 345                 350         

Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu 
        355                 360                 365             

Trp Gly Val Asp Lys Asp Tyr Lys Ser Val Thr Lys Phe His Val Phe 
    370                 375                 380                 

His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln 
385                 390                 395                 400 

Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg 
                405                 410                 415     

Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp 
            420                 425                 430         

Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro 
        435                 440                 445             

Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser 
    450                 455                 460                 

Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His 
465                 470                 475                 480 

Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly Gly 
                485                 490                 495     

Val Asn Lys Asp Gly Gln Cys Thr Leu Ser Gly Asp Ser Asp Asp Met 
            500                 505                 510         

Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp 
        515                 520                 525             

Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr 
    530                 535                 540                 

Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe 
545                 550                 555                 560 

Gly Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser 
                565                 570                 575     

Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly 
            580                 585                 590         

Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu 
        595                 600                 605             

Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp 
    610                 615                 620                 

Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn 
625                 630                 635                 640 

Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu 
                645                 650                 655     

Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn 
            660                 665                 670         

Thr Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Glu Lys 
        675                 680                 685             

Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Ser Ala Gln Pro 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Pro Asp Thr Gly Lys Val Thr Trp Lys Tyr Gln 
705                 710                 715                 720 

Glu Glu Gly Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Gln Glu Asp Val Asp Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Glu His Ser Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys 
        755                 760                 765             

Ile Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr 
    770                 775                 780                 

His Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg 
        835                 840                 845             

Lys Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp 
865                 870                 875                 880 

Lys Asp Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Ala Asn Asn Ala Tyr Ser Glu Gly Thr Gln Cys Ser Ala Asp Leu 
            900                 905                 910         

Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser 
        915                 920                 925             

Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys 
    930                 935                 940                 

Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile 
945                 950                 955                 960 

Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu 
                965                 970                 975     

Lys Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe 
            980                 985                 990         

Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu 
        995                 1000                1005            

Val Thr Ile Glu Ser Thr Ala Ser Val Pro Val Thr Val Thr Val Ala 
    1010                1015                1020                

Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn 
1025                1030                1035                1040

Arg Pro Pro Lys Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys 
                1045                1050                1055    

Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn 
            1060                1065                1070        

Ser Pro Lys Asn Glu Ser Ala Glu Phe Thr Phe Thr Gly Val Val Lys 
        1075                1080                1085            

Ala Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Ala Leu Asn Ser Pro 
    1090                1095                1100                

Ala Pro Leu Gly Glu Leu Glu Ser Asp Ser Phe Val Tyr Thr Ala Pro 
1105                1110                1115                1120

Lys Asn Asn Leu Asn Ala Ser Asn Tyr Ser Asn Tyr Thr Asp Gly Val 
                1125                1130                1135    

Ala Glu Phe Ala Lys Glu Leu Asp Thr Phe Ala Ser Ser Met Asn Asp 
            1140                1145                1150        

Phe Tyr Gly Arg Asp Gly Glu Ser Gly Asn His Arg Met Phe Thr Tyr 
        1155                1160                1165            

Lys Ala Leu Thr Gly His Lys His Arg Phe Ala Asn Asp Val Gln Ile 
    1170                1175                1180                

Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe 
1185                1190                1195                1200

Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu 
                1205                1210                1215    

Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val 
            1220                1225                1230        

Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln 
        1235                1240                1245            

Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val 
    1250                1255                1260                

Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly 
1265                1270                1275                1280

Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala 
                1285                1290                1295    

Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro 
            1300                1305                1310        

Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln 
        1315                1320                1325            

Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Ser Asn Asp Lys Phe 
    1330                1335                1340                

Gly Gly Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr 
1345                1350                1355                1360

Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe 
                1365                1370                1375    

Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala 
            1380                1385                1390        

Ser Glu Met Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr 
        1395                1400                1405            

Leu Ala Ala Met His Leu Ser Lys Pro Glu Lys Gly Pro Glu Thr Ile 
    1410                1415                1420                

Asn Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
1425                1430                1435

<210>   63
<211>   1488
<212>   PRT
<213>   Escherichia coli

<400>   63
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Leu Arg Val Thr Gly Asp Ile Thr Cys Asn Asp Glu Ser Ser 
65                  70                  75                  80  

Asp Gly Phe Thr Phe Thr Pro Gly Asp Lys Val Thr Cys Val Ala Gly 
                85                  90                  95      

Asn Asn Thr Thr Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg 
            100                 105                 110         

Ser Leu Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln 
        115                 120                 125             

Glu Leu Ala Gly Ser Asp Asn Lys Lys Ser Asn Ala Leu Ser Leu Val 
    130                 135                 140                 

Thr Ser Met Asn Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Glu 
145                 150                 155                 160 

Phe Ser Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln 
                165                 170                 175     

Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val 
            180                 185                 190         

Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro 
        195                 200                 205             

Val Val Pro Ala Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser 
    210                 215                 220                 

Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu 
225                 230                 235                 240 

Ile Ile Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Asp Gly Val 
                245                 250                 255     

Val Gly Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu 
            260                 265                 270         

Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile 
        275                 280                 285             

Asp Thr Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala 
    290                 295                 300                 

Leu Thr Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu 
305                 310                 315                 320 

Ile His Arg Tyr Ser Lys Ala Gly Gln Asn His Thr Arg Val Val Pro 
                325                 330                 335     

Asp Glu Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu 
            340                 345                 350         

Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Gly Glu Gly Glu 
        355                 360                 365             

Gln Val Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly 
    370                 375                 380                 

Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys 
385                 390                 395                 400 

Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly 
                405                 410                 415     

Gln Ile Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr 
            420                 425                 430         

Lys Ser Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr 
        435                 440                 445             

Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn 
    450                 455                 460                 

Ala Ala Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu 
465                 470                 475                 480 

Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile 
                485                 490                 495     

Thr Glu Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr 
            500                 505                 510         

Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Asp Gly 
        515                 520                 525             

Lys Leu Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys 
    530                 535                 540                 

Pro Asn Gly Tyr Ser Trp Asn Gly Gly Val Asn Lys Asp Gly Gln Cys 
545                 550                 555                 560 

Thr Leu Asn Ser Asp Pro Asp Asp Met Lys Asn Phe Met Glu Asn Val 
                565                 570                 575     

Leu Arg Tyr Leu Ser Asn Asp Arg Trp Leu Pro Asp Ala Lys Ser Ser 
            580                 585                 590         

Met Thr Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Lys His Gly 
        595                 600                 605             

Gln Val Leu Gly Asn Ser Ala Pro Phe Ala Phe His Lys Asp Phe Thr 
    610                 615                 620                 

Gly Ile Thr Val Lys Pro Met Thr Ser Tyr Gly Asn Leu Asn Pro Asp 
625                 630                 635                 640 

Glu Val Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp 
                645                 650                 655     

Gly Ser Asp Pro Tyr Ser Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro 
            660                 665                 670         

Lys Leu Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys 
        675                 680                 685             

Gly Gly Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu 
    690                 695                 700                 

Glu Ser Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser 
705                 710                 715                 720 

Met Ala Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro 
                725                 730                 735     

Asp Arg Val Arg Gln Arg Arg Ser Thr Pro Ile Trp Val Tyr Glu Arg 
            740                 745                 750         

Tyr Pro Ala Val Asp Gly Lys Pro Pro Tyr Thr Ile Asp Asp Thr Thr 
        755                 760                 765             

Lys Glu Val Ile Trp Lys Tyr Gln Gln Glu Asn Lys Pro Asp Asp Lys 
    770                 775                 780                 

Pro Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln 
785                 790                 795                 800 

Val Thr Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Pro Glu 
                805                 810                 815     

Ser Leu Ala Ala Ala Lys Gln Arg Ile Leu Asp Ala Phe Pro Gly Leu 
            820                 825                 830         

Glu Val Cys Lys Asp Ser Asp Tyr His Tyr Glu Val Asn Cys Leu Glu 
        835                 840                 845             

Tyr Arg Pro Gly Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro 
    850                 855                 860                 

Gln Tyr Thr Gln Leu Asp Leu Gly Ala Asp Thr Ala Lys Ala Met Leu 
865                 870                 875                 880 

Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu 
                885                 890                 895     

Leu Tyr Phe Arg Thr Asn Gly Leu Gln Gly Glu Arg Leu Asn Ser Val 
            900                 905                 910         

Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu 
        915                 920                 925             

Thr Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys 
    930                 935                 940                 

Thr Phe Thr Glu Phe Leu Asn Cys Tyr Thr Asn Asn Ala Tyr Val Gly 
945                 950                 955                 960 

Thr Gln Cys Ser Ala Glu Leu Lys Lys Ser Leu Ile Asp Asn Lys Met 
                965                 970                 975     

Ile Tyr Gly Glu Glu Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Val Val Asn Thr Asn Gly Glu Thr Val Thr Gln Asn Ile Asn Leu Tyr 
1025                1030                1035                1040

Ser Ala Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Glu Val Ser Ile Glu Ser Lys Ala Thr Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ser Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Glu Val Gln Ser Ala Asp Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Lys Trp 
            1140                1145                1150        

Gln His Asp Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Asn Ala Ser Asn Tyr 
    1170                1175                1180                

Thr Gly Gly Leu Glu Gln Phe Ala Asn Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asp Ser Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Pro Gly His Lys His Arg Phe Ala Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Pro Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Lys Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Thr Pro Leu Pro Glu Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly 
                1365                1370                1375    

Trp Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val 
            1380                1385                1390        

Ser Asn Asp Lys Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly 
        1395                1400                1405            

Asn Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr 
    1410                1415                1420                

Asp Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr 
1425                1430                1435                1440

Gln Leu Pro Gly Ala Thr Glu Met Ser Phe Glu Gly Gly Val Ser Gln 
                1445                1450                1455    

Ser Ala Tyr Asn Thr Leu Ala Ser Leu Asn Leu Pro Lys Pro Lys Gln 
            1460                1465                1470        

Gly Pro Glu Thr Ile Asn Lys Val Thr Glu Tyr Ser Met Pro Ala Glu 
        1475                1480                1485            

<210>   64
<211>   1432
<212>   PRT
<213>   Escherichia coli

<400>   64
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Leu Arg Val Thr Gly Asp 
1               5                   10                  15      

Ile Thr Cys Asn Asp Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly 
            20                  25                  30          

Asp Lys Val Thr Cys Val Ala Gly Asn Asn Thr Thr Ile Ala Thr Phe 
        35                  40                  45              

Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val 
    50                  55                  60                  

Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Gly Ser Asp Asn Lys 
65                  70                  75                  80  

Lys Ser Asn Ala Leu Ser Leu Val Thr Ser Met Asn Ser Cys Pro Ala 
                85                  90                  95      

Asn Thr Glu Gln Val Cys Leu Glu Phe Ser Ser Val Ile Glu Ser Lys 
            100                 105                 110         

Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe 
        115                 120                 125             

Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys 
    130                 135                 140                 

Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Ala Thr Thr Pro Gly 
145                 150                 155                 160 

Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln 
                165                 170                 175     

Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu 
            180                 185                 190         

Val Asp Ser Gln Gly Asp Gly Val Val Gly Val Asn Tyr Tyr Thr Asn 
        195                 200                 205             

Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp 
    210                 215                 220                 

Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val 
225                 230                 235                 240 

Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val 
                245                 250                 255     

Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Lys Ala Gly 
            260                 265                 270         

Gln Asn His Thr Arg Val Val Pro Asp Glu Val Arg Lys Val Phe Ala 
        275                 280                 285             

Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn 
    290                 295                 300                 

Gly Ala Thr Leu Gly Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu 
305                 310                 315                 320 

Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala 
                325                 330                 335     

Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu 
            340                 345                 350         

Thr Thr Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys 
        355                 360                 365             

Leu Trp Gly Val Asp Thr Asn Tyr Lys Ser Val Ser Lys Phe His Val 
    370                 375                 380                 

Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly 
385                 390                 395                 400 

Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala 
                405                 410                 415     

Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp 
            420                 425                 430         

Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg 
        435                 440                 445             

Pro Glu Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile 
    450                 455                 460                 

Ser Leu Gly Gln Val Gly Asp Gly Lys Leu Met Val Ile Gly Asn Pro 
465                 470                 475                 480 

His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Asn Gly 
                485                 490                 495     

Gly Val Asn Lys Asp Gly Gln Cys Thr Leu Asn Ser Asp Pro Asp Asp 
            500                 505                 510         

Met Lys Asn Phe Met Glu Asn Val Leu Arg Tyr Leu Ser Asn Asp Arg 
        515                 520                 525             

Trp Leu Pro Asp Ala Lys Ser Ser Met Thr Val Gly Thr Asn Leu Asp 
    530                 535                 540                 

Thr Val Tyr Phe Lys Lys His Gly Gln Val Leu Gly Asn Ser Ala Pro 
545                 550                 555                 560 

Phe Ala Phe His Lys Asp Phe Thr Gly Ile Thr Val Lys Pro Met Thr 
                565                 570                 575     

Ser Tyr Gly Asn Leu Asn Pro Asp Glu Val Pro Leu Leu Ile Leu Asn 
            580                 585                 590         

Gly Phe Glu Tyr Val Thr Gln Trp Gly Ser Asp Pro Tyr Ser Ile Pro 
        595                 600                 605             

Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr 
    610                 615                 620                 

Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu 
625                 630                 635                 640 

Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg 
                645                 650                 655     

Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val 
            660                 665                 670         

Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ser 
        675                 680                 685             

Thr Pro Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Lys Pro 
    690                 695                 700                 

Pro Tyr Thr Ile Asp Asp Thr Thr Lys Glu Val Ile Trp Lys Tyr Gln 
705                 710                 715                 720 

Gln Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp 
                725                 730                 735     

Gln Glu Glu Val Glu Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp 
            740                 745                 750         

Glu Ala Asp His Lys Thr Pro Glu Ser Leu Ala Ala Ala Lys Gln Arg 
        755                 760                 765             

Ile Leu Asp Ala Phe Pro Gly Leu Glu Val Cys Lys Asp Ser Asp Tyr 
    770                 775                 780                 

His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro 
785                 790                 795                 800 

Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Asp Leu Gly 
                805                 810                 815     

Ala Asp Thr Ala Lys Ala Met Leu Gln Ala Ala Asp Leu Gly Thr Asn 
            820                 825                 830         

Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Leu 
        835                 840                 845             

Gln Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn 
    850                 855                 860                 

Met Ser Val Trp Leu Trp Asn Glu Thr Lys Tyr Arg Tyr Glu Glu Gly 
865                 870                 875                 880 

Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys 
                885                 890                 895     

Tyr Thr Asn Asn Ala Tyr Val Gly Thr Gln Cys Ser Ala Glu Leu Lys 
            900                 905                 910         

Lys Ser Leu Ile Asp Asn Lys Met Ile Tyr Gly Glu Glu Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Val Val Asn Thr Asn Gly Glu Thr 
                965                 970                 975     

Val Thr Gln Asn Ile Asn Leu Tyr Ser Ala Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Glu Val 
        995                 1000                1005            

Ser Ile Glu Ser Lys Ala Thr Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ser Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
            1060                1065                1070        

Lys Glu Val Gln Ser Ala Asp Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Lys Trp Gln His Asp Leu Asn Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Asn Ala Ser Asn Tyr Thr Gly Gly Leu Glu Gln Phe Ala 
                1125                1130                1135    

Asn Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asp Ser Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Pro 
        1155                1160                1165            

Gly His Lys His Arg Phe Ala Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Pro Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe 
                1285                1290                1295    

Asp Ile Lys Lys Trp Tyr Pro Asp Gly Thr Pro Leu Pro Glu Phe Tyr 
            1300                1305                1310        

Ser Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His 
        1315                1320                1325            

Arg Lys Ala Arg Gly Asp Glu Val Ser Asn Asp Lys Phe Gly Gly Lys 
    1330                1335                1340                

Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu 
1345                1350                1355                1360

Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys 
                1365                1370                1375    

Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met 
            1380                1385                1390        

Ser Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Asn Thr Leu Ala Ser 
        1395                1400                1405            

Leu Asn Leu Pro Lys Pro Lys Gln Gly Pro Glu Thr Ile Asn Lys Val 
    1410                1415                1420                

Thr Glu Tyr Ser Met Pro Ala Glu 
1425                1430        

<210>   65
<211>   1485
<212>   PRT
<213>   Escherichia coli

<400>   65
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp Pro Glu Pro Glu Pro Glu 
        35                  40                  45              

Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser 
    50                  55                  60                  

Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe 
65                  70                  75                  80  

Thr Phe Thr Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn Thr Thr 
                85                  90                  95      

Ile Ala Thr Phe Asp Thr Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala 
            100                 105                 110         

Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala 
        115                 120                 125             

Ser Asp Asp Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser Ser Asn 
    130                 135                 140                 

Ser Cys Pro Ala Asn Thr Glu Gln Val Cys Leu Thr Phe Ser Ser Val 
145                 150                 155                 160 

Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala 
                165                 170                 175     

Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn Asn Ala 
            180                 185                 190         

Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val Pro Val 
        195                 200                 205             

Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val Ser Ala 
    210                 215                 220                 

Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser 
225                 230                 235                 240 

Glu Gly Arg Leu Val Asp Ser Met Gly Asn Gly Val Val Gly Val Asn 
                245                 250                 255     

Tyr Tyr Thr Ser Ser Gly Arg Gly Val Thr Gly Glu Asn Gly Lys Phe 
            260                 265                 270         

Asn Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu 
        275                 280                 285             

Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu 
    290                 295                 300                 

Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His Arg Tyr 
305                 310                 315                 320 

Ser Gln Ala Gly Lys Asn Asp Glu Arg Glu Val Pro Asp Val Val Arg 
                325                 330                 335     

Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile Asn Leu 
            340                 345                 350         

Ser Leu Ser Asn Gly Glu Ala Leu Ser Glu Gly Asp Gln Thr Phe Glu 
        355                 360                 365             

Arg Thr Asn Glu Phe Leu Glu Gln Phe Glu Ser Gly Gln Ala Lys Glu 
    370                 375                 380                 

Ile Asp Thr Ala Ile Cys Asp Ser Leu Gly Gly Cys Asn Ser Gln Arg 
385                 390                 395                 400 

Trp Phe Ser Leu Thr Ala Arg Asn Val Asn Glu Gly Gln Ile Gln Gly 
                405                 410                 415     

Val Ile Asn Lys Leu Trp Gly Val Asp Lys Asp Tyr Lys Ser Val Thr 
            420                 425                 430         

Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly 
        435                 440                 445             

Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala Phe Pro 
    450                 455                 460                 

Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu 
465                 470                 475                 480 

Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro 
                485                 490                 495     

Ser Leu Val Glu Pro Glu Asn Val Thr Arg Asp Thr Ala Thr Phe Asn 
            500                 505                 510         

Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu Met Val 
        515                 520                 525             

Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr 
    530                 535                 540                 

Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser 
545                 550                 555                 560 

Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val Leu Arg Tyr Leu 
                565                 570                 575     

Ser Asp Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met Thr Val Gly 
            580                 585                 590         

Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln Val Thr Gly 
        595                 600                 605             

Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly Ile Ser Val 
    610                 615                 620                 

Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Glu Met Pro Leu 
625                 630                 635                 640 

Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Asn Asp Pro 
                645                 650                 655     

Tyr Ala Ile Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln 
            660                 665                 670         

Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val 
        675                 680                 685             

Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser Ala Ser 
    690                 695                 700                 

Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala Leu Asn 
705                 710                 715                 720 

Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg 
                725                 730                 735     

Gln Gln Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val 
            740                 745                 750         

Asp Gly Ala Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly Glu Val Lys 
        755                 760                 765             

Trp Lys Tyr Gln Val Glu Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu 
    770                 775                 780                 

Val Ala Ser Trp Leu Glu Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr 
785                 790                 795                 800 

Ala Phe Ile Asp Glu Ala Asp His Lys Thr Glu Asp Ser Leu Lys Ala 
                805                 810                 815     

Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Lys Glu Cys Lys 
            820                 825                 830         

Asp Pro Thr Tyr His Tyr Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly 
        835                 840                 845             

Thr Gly Val Pro Val Thr Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln 
    850                 855                 860                 

Leu Ser Leu Asn Ala Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp 
865                 870                 875                 880 

Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg 
                885                 890                 895     

Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu Glu Arg 
            900                 905                 910         

Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg 
        915                 920                 925             

Tyr Glu Asn Asp Lys Asp Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu 
    930                 935                 940                 

Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys 
945                 950                 955                 960 

Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly 
                965                 970                 975     

Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro Ser Tyr Pro Leu 
            980                 985                 990         

Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg Ser Trp 
        995                 1000                1005            

Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly Ala Val 
    1010                1015                1020                

Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn 
1025                1030                1035                1040

Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu Trp Ala 
                1045                1050                1055    

Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Ser Ala Ser Val Pro Val 
            1060                1065                1070        

Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu Lys His 
        1075                1080                1085            

Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr Tyr Asp Leu 
    1090                1095                1100                

Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile 
1105                1110                1115                1120

Tyr Ile Lys Gly Asn Ser Pro Lys Asn Glu Ser Ala Glu Phe Thr Phe 
                1125                1130                1135    

Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn 
            1140                1145                1150        

Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe 
        1155                1160                1165            

Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly 
    1170                1175                1180                

Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser Ser Met 
1185                1190                1195                1200

Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg Met Phe 
                1205                1210                1215    

Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn Asp Val 
            1220                1225                1230        

Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met Asn Ser 
        1235                1240                1245            

Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp 
    1250                1255                1260                

Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr Pro Leu 
1265                1270                1275                1280

Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala Leu Tyr 
                1285                1290                1295    

Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp Asp Ile 
            1300                1305                1310        

Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala 
        1315                1320                1325            

Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu 
    1330                1335                1340                

Trp Ala Glu Lys Asn Phe Asp Ile Lys Gln Trp Tyr Pro Glu Gly Asp 
1345                1350                1355                1360

Leu Pro Lys Phe Tyr Ser Asp Arg Glu Gly Met Lys Gly Trp Asn Leu 
                1365                1370                1375    

Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly Lys Thr 
            1380                1385                1390        

Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala 
        1395                1400                1405            

Asp Lys Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp Leu Ser 
    1410                1415                1420                

Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro 
1425                1430                1435                1440

Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr 
                1445                1450                1455    

Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln Gln Gly Pro Glu 
            1460                1465                1470        

Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485

<210>   66
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   66
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asp Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asp Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asn Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Met Gly Asn Gly Val Val Gly Val Asn Tyr Tyr Thr Ser Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Lys Phe Asn Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Gln Ala Gly Lys Asn 
            260                 265                 270         

Asp Glu Arg Glu Val Pro Asp Val Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Glu 
    290                 295                 300                 

Ala Leu Ser Glu Gly Asp Gln Thr Phe Glu Arg Thr Asn Glu Phe Leu 
305                 310                 315                 320 

Glu Gln Phe Glu Ser Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Asp Ser Leu Gly Gly Cys Asn Ser Gln Arg Trp Phe Ser Leu Thr Ala 
            340                 345                 350         

Arg Asn Val Asn Glu Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Lys Asp Tyr Lys Ser Val Thr Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Leu Val Glu Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Glu Gly Gly Val 
                485                 490                 495     

Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser Asp Ser Asn Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asp Asp Lys Trp Thr 
        515                 520                 525             

Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe Gly 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Glu Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Asn Asp Pro Tyr Ala Ile Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asn Arg Val Arg Gln Gln Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Val Asp Gly Ala Leu Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Ser Lys Thr Gly Glu Val Lys Trp Lys Tyr Gln Val Glu 
705                 710                 715                 720 

Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Leu Glu 
                725                 730                 735     

Asp Val Asp Gly Lys Gln Glu Thr Arg Tyr Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Glu Asp Ser Leu Lys Ala Ala Lys Ala Lys Ile Phe 
        755                 760                 765             

Glu Lys Phe Pro Gly Leu Lys Glu Cys Lys Asp Pro Thr Tyr His Tyr 
    770                 775                 780                 

Glu Val Asn Cys Leu Glu Tyr Arg Pro Gly Thr Gly Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Gln Tyr Thr Gln Leu Ser Leu Asn Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Lys Ile Glu Tyr Arg Tyr Glu Asn Asp Lys Asp 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys Ser Asp Glu Leu Lys Lys 
            900                 905                 910         

Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Glu Lys Ser Val Asn Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu Lys 
                965                 970                 975     

Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val 
        995                 1000                1005            

Thr Ile Glu Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Lys Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser 
            1060                1065                1070        

Pro Lys Asn Glu Ser Ala Glu Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Ala Leu Asn Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
                1125                1130                1135    

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe 
                1285                1290                1295    

Asp Ile Lys Gln Trp Tyr Pro Glu Gly Asp Leu Pro Lys Phe Tyr Ser 
            1300                1305                1310        

Asp Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Asp Val Gly Lys Thr Lys Phe Gly Glu Arg Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Lys Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Asn 
            1380                1385                1390        

Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Glu Thr Leu Ala Ala Leu 
        1395                1400                1405            

Asn Leu Pro Lys Pro Gln Gln Gly Pro Glu Thr Ile Asn Gln Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   67
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   67
Asp Thr Pro Pro Val Asp Ser Gly Thr Gly Ser Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Asn Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Glu Pro Ile Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Glu Asp Val Thr Cys Val Ala Gly Asn 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Glu Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Ala Ser Asp Asn Lys Lys Ser Asn Ala Val Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asn Ser Cys Pro Ala Asp Thr Glu Gln Val Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Ile Glu Ser Lys Arg Phe Asp Ser Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Pro Glu Glu Phe Lys Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Pro Val Val 
        195                 200                 205             

Pro Val Thr Thr Pro Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Arg Leu Val Asp Ser Gln Gly Tyr Gly Val Ala Gly 
                245                 250                 255     

Val Asn Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Gly Glu Asn Gly 
            260                 265                 270         

Glu Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Glu Gln Val 
        355                 360                 365             

Val Asn Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Ser Tyr Lys Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ala Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Arg Pro Glu Asn Val Thr Arg Glu Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Lys Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Glu Gly Gly Val Asp Lys Asn Gly Gln Cys Thr Arg 
545                 550                 555                 560 

Asn Ser Asp Ser Asn Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Lys Trp Thr Pro Asp Ala Lys Ala Ser Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Asp Thr Val Tyr Phe Lys Arg His Gly Gln Val 
        595                 600                 605             

Thr Gly Asn Ser Ala Glu Phe Gly Phe His Pro Asp Phe Ala Gly Ile 
    610                 615                 620                 

Ser Val Glu His Leu Ser Ser Tyr Gly Asp Leu Asp Pro Gln Lys Met 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Val Gly Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Met Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Gly Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Val Val Glu Gly Glu Leu Pro Tyr Thr Ile Asp Ser Lys Thr Gly Lys 
        755                 760                 765             

Val Thr Trp Lys Tyr Gln Ile Asp Asn Lys Pro Asp Lys Lys Pro Lys 
    770                 775                 780                 

Leu Glu Val Ala Ser Trp Gln Glu Glu Val Asp Gly Lys Gln Val Thr 
785                 790                 795                 800 

Gln Phe Ala Phe Ile Asp Glu Ala Asp His Lys Thr Thr Glu Ser Leu 
                805                 810                 815     

Asp Ala Ala Lys Lys Lys Ile Leu Glu Lys Phe Lys Gly Leu Glu Glu 
            820                 825                 830         

Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Tyr Arg 
        835                 840                 845             

Pro Gly Thr Asn Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg Tyr 
    850                 855                 860                 

Thr Gln Leu Asn Leu Ser Ala Asp Thr Ala Lys Ala Met Val Gln Ala 
865                 870                 875                 880 

Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu Tyr 
                885                 890                 895     

Phe Arg Thr Asn Gly Arg Lys Gly Glu Arg Leu Ser Ser Val Asp Leu 
            900                 905                 910         

Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Glu Ile Glu 
        915                 920                 925             

Tyr Ser Tyr Asp Ser Ser Lys Glu Asp Glu Leu Gly Phe Lys Thr Phe 
    930                 935                 940                 

Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Thr Gly Gly Thr 
945                 950                 955                 960 

Gln Cys Ser Asp Glu Leu Lys Lys Ser Leu Val Asp Asn Asn Met Ile 
                965                 970                 975     

Tyr Gly Glu Lys Ser Val Asn Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ala Val Ser Ala Glu Gly Glu Lys Val Thr Glu Thr Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Lys Glu Val Thr Ile Glu Ser Ser Ala Ser Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Lys Val Thr Lys Thr Tyr 
    1090                1095                1100                

Asp Leu Lys Ala Asn Asp Lys Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asn Ser Pro Lys Asn Glu Ser Ala Glu Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp 
            1140                1145                1150        

Lys Asn Ala Leu Asn Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Asp 
        1155                1160                1165            

Ala Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe 
    1170                1175                1180                

Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Thr Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Glu Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Lys Asn Phe Asp Ile Lys Thr Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Asn Leu Pro Ala Phe Tyr Ser Glu Arg Glu Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Glu Val Gly 
            1380                1385                1390        

Lys Thr Lys Phe Gly Glu Arg Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Thr Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Asn Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Ser Glu Met Asn Phe Glu Gly Gly Val Ser Gln Ser 
                1445                1450                1455    

Ala Tyr Glu Thr Leu Ala Ala Leu Asn Leu Pro Lys Pro Gln Gln Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Gln Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   68
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   68
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Glu 
            20                  25                  30          

Asp Val Thr Cys Val Ala Gly Asn Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Glu Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Ala Ser Asp Asn Lys Lys Ser 
65                  70                  75                  80  

Asn Ala Val Ser Leu Val Thr Ser Ser Asn Ser Cys Pro Ala Asp Thr 
                85                  90                  95      

Glu Gln Val Cys Leu Thr Phe Ser Ser Val Ile Glu Ser Lys Arg Phe 
            100                 105                 110         

Asp Ser Leu Tyr Lys Gln Ile Asp Leu Ala Pro Glu Glu Phe Lys Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Pro Val Val Pro Val Thr Thr Pro Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Arg Leu Val Asp 
            180                 185                 190         

Ser Gln Gly Tyr Gly Val Ala Gly Val Asn Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Gly Glu Asn Gly Glu Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Asp Glu Gly Glu Gln Val Val Asn Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Ser Tyr Lys Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ala Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Arg Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Glu Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Lys Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Glu Gly Gly Val 
                485                 490                 495     

Asp Lys Asn Gly Gln Cys Thr Arg Asn Ser Asp Ser Asn Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Lys Trp Thr 
        515                 520                 525             

Pro Asp Ala Lys Ala Ser Met Thr Val Gly Thr Asn Leu Asp Thr Val 
    530                 535                 540                 

Tyr Phe Lys Arg His Gly Gln Val Thr Gly Asn Ser Ala Glu Phe Gly 
545                 550                 555                 560 

Phe His Pro Asp Phe Ala Gly Ile Ser Val Glu His Leu Ser Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asp Pro Gln Lys Met Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Val Gly Gly Asp Pro Tyr Ala Val Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Met Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Gly Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Val Val Glu Gly Glu Leu Pro Tyr 
    690                 695                 700                 

Thr Ile Asp Ser Lys Thr Gly Lys Val Thr Trp Lys Tyr Gln Ile Asp 
705                 710                 715                 720 

Asn Lys Pro Asp Lys Lys Pro Lys Leu Glu Val Ala Ser Trp Gln Glu 
                725                 730                 735     

Glu Val Asp Gly Lys Gln Val Thr Gln Phe Ala Phe Ile Asp Glu Ala 
            740                 745                 750         

Asp His Lys Thr Thr Glu Ser Leu Asp Ala Ala Lys Lys Lys Ile Leu 
        755                 760                 765             

Glu Lys Phe Lys Gly Leu Glu Glu Cys Lys Asp Ser Thr Tyr His Tyr 
    770                 775                 780                 

Glu Ile Asn Cys Leu Glu Tyr Arg Pro Gly Thr Asn Val Pro Val Thr 
785                 790                 795                 800 

Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Ser Ala Asp 
                805                 810                 815     

Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile Gln 
            820                 825                 830         

Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Asn Gly Arg Lys Gly 
        835                 840                 845             

Glu Arg Leu Ser Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met Ser 
    850                 855                 860                 

Val Trp Leu Trp Asn Glu Ile Glu Tyr Ser Tyr Asp Ser Ser Lys Glu 
865                 870                 875                 880 

Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr Ala 
                885                 890                 895     

Asn Asp Ala Tyr Thr Gly Gly Thr Gln Cys Ser Asp Glu Leu Lys Lys 
            900                 905                 910         

Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Glu Lys Ser Val Asn Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ala Val Ser Ala Glu Gly Glu Lys 
                965                 970                 975     

Val Thr Glu Thr Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Lys Glu Val 
        995                 1000                1005            

Thr Ile Glu Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Lys Val Thr Lys Thr Tyr Asp Leu Lys Ala Asn Asp Lys Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asn Ser 
            1060                1065                1070        

Pro Lys Asn Glu Ser Ala Glu Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Ala Leu Asn Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Asp Ala Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
                1125                1130                1135    

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Thr Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Glu Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Lys Asn Phe 
                1285                1290                1295    

Asp Ile Lys Thr Trp Tyr Pro Asp Gly Asn Leu Pro Ala Phe Tyr Ser 
            1300                1305                1310        

Glu Arg Glu Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Glu Val Gly Lys Thr Lys Phe Gly Glu Arg Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Thr Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Asn Ala Tyr Gln Leu Pro Gly Ala Ser Glu Met Asn 
            1380                1385                1390        

Phe Glu Gly Gly Val Ser Gln Ser Ala Tyr Glu Thr Leu Ala Ala Leu 
        1395                1400                1405            

Asn Leu Pro Lys Pro Gln Gln Gly Pro Glu Thr Ile Asn Gln Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

<210>   69
<211>   1487
<212>   PRT
<213>   Escherichia coli

<400>   69
Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      

Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          

Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              

Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  

Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  

Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      

Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         

Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             

Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 

Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 

Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     

Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         

Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             

Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 

Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 

Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     

Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         

Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             

Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 

Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 

Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     

Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         

Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             

Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 

Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 

Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     

Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         

Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             

Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 

Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 

Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     

Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         

Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             

Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 

Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 

Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     

Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         

Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             

Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 

Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 

Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     

Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         

Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             

Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 

Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 

Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     

Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         

Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly 
        755                 760                 765             

Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 

Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
785                 790                 795                 800 

Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser 
                805                 810                 815     

Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln 
            820                 825                 830         

Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg 
        835                 840                 845             

Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 

Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 

Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     

Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val Asp 
            900                 905                 910         

Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
        915                 920                 925             

Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 

Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
945                 950                 955                 960 

Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     

Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         

Pro Leu Asn Tyr Met Glu Lys Pro Leu Thr Arg Leu Met Leu Gly Arg 
        995                 1000                1005            

Ser Trp Trp Asp Leu Asn Ile Lys Val Asp Val Glu Lys Tyr Pro Gly 
    1010                1015                1020                

Ser Val Ser Ala Lys Gly Glu Ser Val Thr Glu Asn Ile Ser Leu Tyr 
1025                1030                1035                1040

Ser Asn Pro Thr Lys Trp Phe Ala Gly Asn Met Gln Ser Thr Gly Leu 
                1045                1050                1055    

Trp Ala Pro Ala Gln Gln Asp Val Thr Ile Lys Ser Ser Ala Ser Val 
            1060                1065                1070        

Pro Val Thr Val Thr Val Ala Leu Ala Asp Asp Leu Thr Gly Arg Glu 
        1075                1080                1085            

Lys His Glu Val Ala Leu Asn Arg Pro Pro Arg Val Thr Lys Thr Tyr 
    1090                1095                1100                

Thr Leu Glu Ala Asn Gly Glu Val Thr Phe Lys Val Pro Tyr Gly Gly 
1105                1110                1115                1120

Leu Ile Tyr Ile Lys Gly Asp Ser Lys Asp Asp Val Ser Ala Asn Phe 
                1125                1130                1135    

Thr Phe Thr Gly Val Val Lys Ala Pro Phe Tyr Lys Asp Gly Glu Trp 
            1140                1145                1150        

Lys Asn Asp Leu Asp Ser Pro Ala Pro Leu Gly Glu Leu Glu Ser Ala 
        1155                1160                1165            

Ser Phe Val Tyr Thr Thr Pro Lys Lys Asn Leu Glu Ala Ser Asn Phe 
    1170                1175                1180                

Thr Gly Gly Val Ala Glu Phe Ala Lys Asp Leu Asp Thr Phe Ala Ser 
1185                1190                1195                1200

Ser Met Asn Asp Phe Tyr Gly Arg Asn Asp Glu Asp Gly Lys His Arg 
                1205                1210                1215    

Met Phe Thr Tyr Lys Asn Leu Thr Gly His Lys His Arg Phe Thr Asn 
            1220                1225                1230        

Asp Val Gln Ile Ser Ile Gly Asp Ala His Ser Gly Tyr Pro Val Met 
        1235                1240                1245            

Asn Ser Ser Phe Ser Thr Asn Ser Thr Thr Leu Pro Thr Thr Pro Leu 
    1250                1255                1260                

Asn Asp Trp Leu Ile Trp His Glu Val Gly His Asn Ala Ala Glu Thr 
1265                1270                1275                1280

Pro Leu Asn Val Pro Gly Ala Thr Glu Val Ala Asn Asn Val Leu Ala 
                1285                1290                1295    

Leu Tyr Met Gln Asp Arg Tyr Leu Gly Lys Met Asn Arg Val Ala Asp 
            1300                1305                1310        

Asp Ile Thr Val Ala Pro Glu Tyr Leu Asp Glu Ser Asn Gly Gln Ala 
        1315                1320                1325            

Trp Ala Arg Gly Gly Ala Gly Asp Arg Leu Leu Met Tyr Ala Gln Leu 
    1330                1335                1340                

Lys Glu Trp Ala Glu Glu Asn Phe Asp Ile Lys Gln Trp Tyr Pro Asp 
1345                1350                1355                1360

Gly Glu Leu Pro Lys Phe Tyr Ser Asp Arg Lys Gly Met Lys Gly Trp 
                1365                1370                1375    

Asn Leu Phe Gln Leu Met His Arg Lys Ala Arg Gly Asp Asp Val Gly 
            1380                1385                1390        

Asn Ser Thr Phe Gly Gly Lys Asn Tyr Cys Ala Glu Ser Asn Gly Asn 
        1395                1400                1405            

Ala Ala Asp Thr Leu Met Leu Cys Ala Ser Trp Val Ala Gln Ala Asp 
    1410                1415                1420                

Leu Ser Glu Phe Phe Lys Lys Trp Asn Pro Gly Ala Ser Ala Tyr Gln 
1425                1430                1435                1440

Leu Pro Gly Ala Thr Glu Met Ser Phe Gln Gly Gly Val Ser Ser Ser 
                1445                1450                1455    

Ala Tyr Ser Thr Leu Ala Ser Leu Lys Leu Pro Lys Pro Glu Lys Gly 
            1460                1465                1470        

Pro Glu Thr Ile Asn Lys Val Thr Glu His Lys Met Ser Ala Glu 
        1475                1480                1485        

<210>   70
<211>   1431
<212>   PRT
<213>   Escherichia coli

<400>   70
Lys Thr Gly Tyr Leu Thr Leu Gly Gly Ser Gln Arg Val Thr Gly Ala 
1               5                   10                  15      

Thr Cys Asn Gly Glu Ser Ser Asp Gly Phe Thr Phe Thr Pro Gly Asn 
            20                  25                  30          

Thr Val Ser Cys Val Val Gly Ser Thr Thr Ile Ala Thr Phe Asn Thr 
        35                  40                  45              

Gln Ser Glu Ala Ala Arg Ser Leu Arg Ala Val Asp Lys Val Ser Phe 
    50                  55                  60                  

Ser Leu Glu Asp Ala Gln Glu Leu Ala Asn Ser Glu Asn Lys Lys Thr 
65                  70                  75                  80  

Asn Ala Ile Ser Leu Val Thr Ser Ser Asp Ser Cys Pro Ala Asp Ala 
                85                  90                  95      

Glu Gln Leu Cys Leu Thr Phe Ser Ser Val Val Asp Arg Ala Arg Phe 
            100                 105                 110         

Glu Lys Leu Tyr Lys Gln Ile Asp Leu Ala Thr Asp Asn Phe Ser Lys 
        115                 120                 125             

Leu Val Asn Glu Glu Val Glu Asn Asn Ala Ala Thr Asp Lys Ala Pro 
    130                 135                 140                 

Ser Thr His Thr Ser Thr Val Val Pro Val Thr Thr Glu Gly Thr Lys 
145                 150                 155                 160 

Pro Asp Leu Asn Ala Ser Phe Val Ser Ala Asn Ala Glu Gln Phe Tyr 
                165                 170                 175     

Gln Tyr Gln Pro Thr Glu Ile Ile Leu Ser Glu Gly Gln Leu Val Asp 
            180                 185                 190         

Ser Leu Gly Asn Gly Val Ala Gly Val Asp Tyr Tyr Thr Asn Ser Gly 
        195                 200                 205             

Arg Gly Val Thr Asp Glu Asn Gly Lys Phe Ser Phe Ser Trp Gly Glu 
    210                 215                 220                 

Thr Ile Ser Phe Gly Ile Asp Thr Phe Glu Leu Gly Ser Val Arg Gly 
225                 230                 235                 240 

Asn Lys Ser Thr Ile Ala Leu Thr Glu Leu Gly Asp Glu Val Arg Gly 
                245                 250                 255     

Ala Asn Ile Asp Gln Leu Ile His Arg Tyr Ser Thr Thr Gly Gln Asn 
            260                 265                 270         

Asn Thr Arg Val Val Pro Asp Asp Val Arg Lys Val Phe Ala Glu Tyr 
        275                 280                 285             

Pro Asn Val Ile Asn Glu Ile Ile Asn Leu Ser Leu Ser Asn Gly Ala 
    290                 295                 300                 

Thr Leu Asp Glu Gly Asp Gln Asn Val Val Leu Pro Asn Glu Phe Ile 
305                 310                 315                 320 

Glu Gln Phe Lys Thr Gly Gln Ala Lys Glu Ile Asp Thr Ala Ile Cys 
                325                 330                 335     

Ala Lys Thr Asp Gly Cys Asn Glu Ala Arg Trp Phe Ser Leu Thr Thr 
            340                 345                 350         

Arg Asn Val Asn Asp Gly Gln Ile Gln Gly Val Ile Asn Lys Leu Trp 
        355                 360                 365             

Gly Val Asp Thr Asn Tyr Gln Ser Val Ser Lys Phe His Val Phe His 
    370                 375                 380                 

Asp Ser Thr Asn Phe Tyr Gly Ser Thr Gly Asn Ala Arg Gly Gln Ala 
385                 390                 395                 400 

Val Val Asn Ile Ser Asn Ser Ala Phe Pro Ile Leu Met Ala Arg Asn 
                405                 410                 415     

Asp Lys Asn Tyr Trp Leu Ala Phe Gly Glu Lys Arg Ala Trp Asp Lys 
            420                 425                 430         

Asn Glu Leu Ala Tyr Ile Thr Glu Ala Pro Ser Ile Val Gln Pro Glu 
        435                 440                 445             

Asn Val Thr Arg Asp Thr Ala Thr Phe Asn Leu Pro Phe Ile Ser Leu 
    450                 455                 460                 

Gly Gln Val Gly Glu Gly Lys Leu Met Val Ile Gly Asn Pro His Tyr 
465                 470                 475                 480 

Asn Ser Ile Leu Arg Cys Pro Asn Gly Tyr Ser Trp Gly Gly Gly Val 
                485                 490                 495     

Asn Ser Lys Gly Glu Cys Thr Leu Ser Gly Asp Ser Asp Asp Met Lys 
            500                 505                 510         

His Phe Met Gln Asn Val Leu Arg Tyr Leu Ser Asn Asp Ile Trp Gln 
        515                 520                 525             

Pro Asn Thr Lys Ser Ile Met Thr Val Gly Thr Asn Leu Glu Asn Val 
    530                 535                 540                 

Tyr Phe Lys Lys Ala Gly Gln Val Leu Gly Asn Ser Ala Pro Phe Ala 
545                 550                 555                 560 

Phe His Glu Asp Phe Thr Gly Ile Thr Val Lys Gln Leu Thr Ser Tyr 
                565                 570                 575     

Gly Asp Leu Asn Pro Glu Glu Ile Pro Leu Leu Ile Leu Asn Gly Phe 
            580                 585                 590         

Glu Tyr Val Thr Gln Trp Ser Gly Asp Pro Tyr Ala Val Pro Leu Arg 
        595                 600                 605             

Ala Asp Thr Ser Lys Pro Lys Leu Thr Gln Gln Asp Val Thr Asp Leu 
    610                 615                 620                 

Ile Ala Tyr Leu Asn Lys Gly Gly Ser Val Leu Ile Met Glu Asn Val 
625                 630                 635                 640 

Met Ser Asn Leu Lys Glu Glu Ser Ala Ser Ser Phe Val Arg Leu Leu 
                645                 650                 655     

Asp Ala Ala Gly Leu Ser Met Ala Leu Asn Lys Ser Val Val Asn Asn 
            660                 665                 670         

Asp Pro Gln Gly Tyr Pro Asp Arg Val Arg Gln Arg Arg Ala Thr Gly 
        675                 680                 685             

Ile Trp Val Tyr Glu Arg Tyr Pro Ala Ala Asp Gly Ala Gln Pro Pro 
    690                 695                 700                 

Tyr Thr Ile Asp Pro Asn Thr Gly Glu Val Thr Trp Lys Tyr Gln Gln 
705                 710                 715                 720 

Asp Asn Lys Pro Asp Asp Lys Pro Lys Leu Glu Val Ala Ser Trp Gln 
                725                 730                 735     

Glu Glu Val Glu Gly Lys Gln Val Thr Arg Tyr Ala Phe Ile Asp Glu 
            740                 745                 750         

Ala Glu Tyr Thr Thr Glu Glu Ser Leu Glu Ala Ala Lys Ala Lys Ile 
        755                 760                 765             

Phe Glu Lys Phe Pro Gly Leu Gln Glu Cys Lys Asp Ser Thr Tyr His 
    770                 775                 780                 

Tyr Glu Ile Asn Cys Leu Glu Arg Arg Pro Gly Thr Asp Val Pro Val 
785                 790                 795                 800 

Thr Gly Gly Met Tyr Val Pro Arg Tyr Thr Gln Leu Asn Leu Asp Ala 
                805                 810                 815     

Asp Thr Ala Lys Ala Met Val Gln Ala Ala Asp Leu Gly Thr Asn Ile 
            820                 825                 830         

Gln Arg Leu Tyr Gln His Glu Leu Tyr Phe Arg Thr Lys Gly Ser Lys 
        835                 840                 845             

Gly Glu Arg Leu Asn Ser Val Asp Leu Glu Arg Leu Tyr Gln Asn Met 
    850                 855                 860                 

Ser Val Trp Leu Trp Asn Asp Thr Lys Tyr Arg Tyr Glu Glu Gly Lys 
865                 870                 875                 880 

Glu Asp Glu Leu Gly Phe Lys Thr Phe Thr Glu Phe Leu Asn Cys Tyr 
                885                 890                 895     

Ala Asn Asp Ala Tyr Ala Gly Gly Thr Lys Cys Ser Ala Asp Leu Lys 
            900                 905                 910         

Lys Ser Leu Val Asp Asn Asn Met Ile Tyr Gly Asp Gly Ser Ser Lys 
        915                 920                 925             

Ala Gly Met Met Asn Pro Ser Tyr Pro Leu Asn Tyr Met Glu Lys Pro 
    930                 935                 940                 

Leu Thr Arg Leu Met Leu Gly Arg Ser Trp Trp Asp Leu Asn Ile Lys 
945                 950                 955                 960 

Val Asp Val Glu Lys Tyr Pro Gly Ser Val Ser Ala Lys Gly Glu Ser 
                965                 970                 975     

Val Thr Glu Asn Ile Ser Leu Tyr Ser Asn Pro Thr Lys Trp Phe Ala 
            980                 985                 990         

Gly Asn Met Gln Ser Thr Gly Leu Trp Ala Pro Ala Gln Gln Asp Val 
        995                 1000                1005            

Thr Ile Lys Ser Ser Ala Ser Val Pro Val Thr Val Thr Val Ala Leu 
    1010                1015                1020                

Ala Asp Asp Leu Thr Gly Arg Glu Lys His Glu Val Ala Leu Asn Arg 
1025                1030                1035                1040

Pro Pro Arg Val Thr Lys Thr Tyr Thr Leu Glu Ala Asn Gly Glu Val 
                1045                1050                1055    

Thr Phe Lys Val Pro Tyr Gly Gly Leu Ile Tyr Ile Lys Gly Asp Ser 
            1060                1065                1070        

Lys Asp Asp Val Ser Ala Asn Phe Thr Phe Thr Gly Val Val Lys Ala 
        1075                1080                1085            

Pro Phe Tyr Lys Asp Gly Glu Trp Lys Asn Asp Leu Asp Ser Pro Ala 
    1090                1095                1100                

Pro Leu Gly Glu Leu Glu Ser Ala Ser Phe Val Tyr Thr Thr Pro Lys 
1105                1110                1115                1120

Lys Asn Leu Glu Ala Ser Asn Phe Thr Gly Gly Val Ala Glu Phe Ala 
                1125                1130                1135    

Lys Asp Leu Asp Thr Phe Ala Ser Ser Met Asn Asp Phe Tyr Gly Arg 
            1140                1145                1150        

Asn Asp Glu Asp Gly Lys His Arg Met Phe Thr Tyr Lys Asn Leu Thr 
        1155                1160                1165            

Gly His Lys His Arg Phe Thr Asn Asp Val Gln Ile Ser Ile Gly Asp 
    1170                1175                1180                

Ala His Ser Gly Tyr Pro Val Met Asn Ser Ser Phe Ser Thr Asn Ser 
1185                1190                1195                1200

Thr Thr Leu Pro Thr Thr Pro Leu Asn Asp Trp Leu Ile Trp His Glu 
                1205                1210                1215    

Val Gly His Asn Ala Ala Glu Thr Pro Leu Asn Val Pro Gly Ala Thr 
            1220                1225                1230        

Glu Val Ala Asn Asn Val Leu Ala Leu Tyr Met Gln Asp Arg Tyr Leu 
        1235                1240                1245            

Gly Lys Met Asn Arg Val Ala Asp Asp Ile Thr Val Ala Pro Glu Tyr 
    1250                1255                1260                

Leu Asp Glu Ser Asn Gly Gln Ala Trp Ala Arg Gly Gly Ala Gly Asp 
1265                1270                1275                1280

Arg Leu Leu Met Tyr Ala Gln Leu Lys Glu Trp Ala Glu Glu Asn Phe 
                1285                1290                1295    

Asp Ile Lys Gln Trp Tyr Pro Asp Gly Glu Leu Pro Lys Phe Tyr Ser 
            1300                1305                1310        

Asp Arg Lys Gly Met Lys Gly Trp Asn Leu Phe Gln Leu Met His Arg 
        1315                1320                1325            

Lys Ala Arg Gly Asp Asp Val Gly Asn Ser Thr Phe Gly Gly Lys Asn 
    1330                1335                1340                

Tyr Cys Ala Glu Ser Asn Gly Asn Ala Ala Asp Thr Leu Met Leu Cys 
1345                1350                1355                1360

Ala Ser Trp Val Ala Gln Ala Asp Leu Ser Glu Phe Phe Lys Lys Trp 
                1365                1370                1375    

Asn Pro Gly Ala Ser Ala Tyr Gln Leu Pro Gly Ala Thr Glu Met Ser 
            1380                1385                1390        

Phe Gln Gly Gly Val Ser Ser Ser Ala Tyr Ser Thr Leu Ala Ser Leu 
        1395                1400                1405            

Lys Leu Pro Lys Pro Glu Lys Gly Pro Glu Thr Ile Asn Lys Val Thr 
    1410                1415                1420                

Glu His Lys Met Ser Ala Glu 
1425                1430    

