                         SEQUENCE LISTING

<110>  Metheresis Translational Research S.A.
 
<120>  New antibody fragments, compositions and uses thereof

<130>  BWO15799-CF

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1155
<212>  DNA
<213>  artificial

<220>
<223>  DCD-MvDN30.1 heavy chain

<400>  1
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgg ccactcccag       60

gtccaactgc aacagcctgg gactgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagt tactggatac actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctagca gcggtcgtac taactacaac      240

gagaaattca agaacaaggt cacagtgact gtagacaaat cttccaccac agcctacatg      300

caactcagca acctgacatc tgaggactct gcggtctatt actgtgcaag taggggctac      360

tggggccaag gcaccactct cacagtctcc tcagctagca cgaagggccc atcggtcttc      420

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      480

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      540

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      600

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      660

agcaacacca aggtggacaa gaaagttgag cccaaatctt gtgcaagcac gaagggccca      720

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      780

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      840

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      900

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      960

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact     1020

cacacaggtg ccgcatggag ccacccccag ttcgaaaaag gggccgcatg gagccacccc     1080

cagttcgaaa aaggggccgc atggagccac ccccagttcg aaaaaggggc cgcacaccat     1140

caccatcacc attag                                                      1155


<210>  2
<211>  384
<212>  PRT
<213>  artificial

<220>
<223>  DCD-MvDN30.1 heavy chain aa

<400>  2

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Gly His Ser Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Ser Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Lys Val Thr Val Thr Val Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Arg Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ala Ser Thr Lys Gly Pro 
225                 230                 235                 240 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                245                 250                 255     


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            260                 265                 270         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        275                 280                 285             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    290                 295                 300                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
305                 310                 315                 320 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                325                 330                 335     


Cys Asp Lys Thr His Thr Gly Ala Ala Trp Ser His Pro Gln Phe Glu 
            340                 345                 350         


Lys Gly Ala Ala Trp Ser His Pro Gln Phe Glu Lys Gly Ala Ala Trp 
        355                 360                 365             


Ser His Pro Gln Phe Glu Lys Gly Ala Ala His His His His His His 
    370                 375                 380                 


<210>  3
<211>  334
<212>  DNA
<213>  artificial

<220>
<223>  DN30 VH domain

<400>  3
ggtccaactg caacagcctg ggactgaact ggtgaagcct ggggcttcag tgaagctgtc       60

ctgcaaggct tctggctaca ccttcaccag ttactggata cactgggtga agcagaggcc      120

tggacaaggc cttgagtgga ttggagagat taatcctagc agcggtcgta ctaactacaa      180

cgagaaattc aagaacaagg tcacagtgac tgtagacaaa tcttccacca cagcctacat      240

gcaactcagc aacctgacat ctgaggactc tgcggtctat tactgtgcaa gtaggggcta      300

ctggggccaa ggcaccactc tcacagtctc ctca                                  334


<210>  4
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  DN30 VH domain aa

<400>  4

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Val Thr Val Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  5
<211>  315
<212>  DNA
<213>  artificial

<220>
<223>  human CH1 domain

<400>  5
aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg       60

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      120

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      180

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      240

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      300

gacaaaactc acaca                                                       315


<210>  6
<211>  105
<212>  PRT
<213>  artificial

<220>
<223>  human CH1 domain aa

<400>  6

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
1               5                   10                  15      


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            20                  25                  30          


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        35                  40                  45              


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    50                  55                  60                  


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
65                  70                  75                  80  


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                85                  90                  95      


Pro Lys Ser Cys Asp Lys Thr His Thr 
            100                 105 


<210>  7
<211>  108
<212>  DNA
<213>  artificial

<220>
<223>  strep tag

<400>  7
ggtgccgcat ggagccaccc ccagttcgaa aaaggggccg catggagcca cccccagttc       60

gaaaaagggg ccgcatggag ccacccccag ttcgaaaaag gggccgca                   108


<210>  8
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  polyhis tag

<400>  8
caccatcacc atcaccat                                                     18


<210>  9
<211>  1035
<212>  DNA
<213>  artificial

<220>
<223>  DCD-MvDN30.1 light chain

<400>  9
atggagacag acacaatcct gctatgggtg ctgctgctct gggttccagg ctccactggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg gtagttatat gagttggttc      180

caacagagac caggacagcc acccaaactc ctcatctctg ctgcatccaa ccttgaatct      240

ggcatcccag ccaggtttag tggcagtggc tctgggacag acttcaccct caatatccat      300

cctgtggagg aggaggatgt tgcaacctat tactgtcagc aaagttatga agacccgctc      360

acgttcggtg ctggtaccaa ggtggagatc aaacgaactg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtactgtg      720

gctgcaccat ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc      780

tctgttgtgt gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg      840

gataacgccc tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac      900

agcacctaca gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa      960

gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac     1020

aggggagagt gttaa                                                      1035


<210>  10
<211>  344
<212>  PRT
<213>  artificial

<220>
<223>  DCD-MvDN30.1 light chain aa

<400>  10

Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Gly Ser Tyr Met Ser Trp Phe Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Val 
225                 230                 235                 240 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
                245                 250                 255     


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            260                 265                 270         


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        275                 280                 285             


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    290                 295                 300                 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
305                 310                 315                 320 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                325                 330                 335     


Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 


<210>  11
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  DN30 VL domain

<400>  11
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg gtagttatat gagttggttc      120

caacagagac caggacagcc acccaaactc ctcatctctg ctgcatccaa ccttgaatct      180

ggcatcccag ccaggtttag tggcagtggc tctgggacag acttcaccct caatatccat      240

cctgtggagg aggaggatgt tgcaacctat tactgtcagc aaagttatga agacccgctc      300

acgttcggtg ctggtaccaa ggtggagatc aaacga                                336


<210>  12
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  DN30 VL domain aa

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Gly Ser Tyr Met Ser Trp Phe Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  13
<211>  318
<212>  DNA
<213>  artificial

<220>
<223>  human CL domain

<400>  13
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  14
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  human CL domain aa

<400>  14

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  15
<211>  1023
<212>  DNA
<213>  artificial

<220>
<223>  DCD-MvDN30.2 heavy chain

<400>  15
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgg ccactcccag       60

gtccaactgc aacagcctgg gactgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagt tactggatac actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggagagatt aatcctagca gcggtcgtac taactacaac      240

gagaaattca agaacaaggt cacagtgact gtagacaaat cttccaccac agcctacatg      300

caactcagca acctgacatc tgaggactct gcggtctatt actgtgcaag taggggctac      360

tggggccaag gcaccactct cacagtctcc tcagctagca cgaagggccc atcggtcttc      420

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      480

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      540

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      600

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      660

agcaacacca aggtggacaa gaaagttgag cccaaatctt gtactgtggc tgcaccatct      720

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      780

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      840

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      900

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      960

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     1020

taa                                                                   1023


<210>  16
<211>  340
<212>  PRT
<213>  artificial

<220>
<223>  DCD-MvDN30.2 heavy chain aa

<400>  16

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Gly His Ser Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Ser Gly Arg Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Lys Val Thr Val Thr Val Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Arg Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Thr Val Ala Ala Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                245                 250                 255     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            260                 265                 270         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        275                 280                 285             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    290                 295                 300                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
305                 310                 315                 320 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                325                 330                 335     


Arg Gly Glu Cys 
            340 


<210>  17
<211>  1167
<212>  DNA
<213>  artificial

<220>
<223>  DCD-MvDN30.2 light chain

<400>  17
atggagacag acacaatcct gctatgggtg ctgctgctct gggttccagg ctccactggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg gtagttatat gagttggttc      180

caacagagac caggacagcc acccaaactc ctcatctctg ctgcatccaa ccttgaatct      240

ggcatcccag ccaggtttag tggcagtggc tctgggacag acttcaccct caatatccat      300

cctgtggagg aggaggatgt tgcaacctat tactgtcagc aaagttatga agacccgctc      360

acgttcggtg ctggtaccaa ggtggagatc aaacgaactg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtgcaagc      720

acgaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      780

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      840

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      900

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      960

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     1020

tgtgacaaaa ctcacacagg tgccgcatgg agccaccccc agttcgaaaa aggggccgca     1080

tggagccacc cccagttcga aaaaggggcc gcatggagcc acccccagtt cgaaaaaggg     1140

gccgcacacc atcaccatca ccattag                                         1167


<210>  18
<211>  388
<212>  PRT
<213>  artificial

<220>
<223>  DCD-MvDN30.2 light chain aa

<400>  18

Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Gly Ser Tyr Met Ser Trp Phe Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Ser Ala Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ala Ser 
225                 230                 235                 240 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                245                 250                 255     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            260                 265                 270         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        275                 280                 285             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    290                 295                 300                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
305                 310                 315                 320 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                325                 330                 335     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Ala Ala Trp Ser His 
            340                 345                 350         


Pro Gln Phe Glu Lys Gly Ala Ala Trp Ser His Pro Gln Phe Glu Lys 
        355                 360                 365             


Gly Ala Ala Trp Ser His Pro Gln Phe Glu Lys Gly Ala Ala His His 
    370                 375                 380                 


His His His His 
385             


<210>  19
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRH1 aa

<400>  19

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  20
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRH1

<400>  20
ggctacacct tcaccagtta ctgg                                              24


<210>  21
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRH2 aa

<400>  21

Ile Asn Pro Ser Ser Gly Arg Thr 
1               5               


<210>  22
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRH2

<400>  22
attaatccta gcagcggtcg tact                                              24


<210>  23
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRH3 aa

<400>  23

Ala Ser Arg Gly Tyr 
1               5   


<210>  24
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRH3

<400>  24
gcaagtaggg gctac                                                        15


<210>  25
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRL1 aa

<400>  25

Gln Ser Val Asp Tyr Asp Gly Gly Ser Tyr 
1               5                   10  


<210>  26
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRL1

<400>  26
caaagtgttg attatgatgg tggtagttat                                        30


<210>  27
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRL2 aa

<400>  27

Ala Ala Ser 
1           


<210>  28
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRL2

<400>  28
gctgcatcc                                                                9


<210>  29
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  DN30 CDRL3 aa

<400>  29

Gln Gln Ser Tyr Glu Asp Pro Leu Thr 
1               5                   


<210>  30
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  DN30 CDRL3 aa

<400>  30
cagcaaagtt atgaagaccc gctcacg                                           27


