
                                SEQUENCE LISTING

<110> Children's Hospital Medical Center
      Hegde, Rashmi

<120> USE OF SMALL MOLECULE INHIBITORS
  TARGETING EYA TYROSINE PHOSPHATASE
  

<130> CHMC45.001WO2

<150> 61/753345           
<151> 2013-01-16  

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 273
<212> PRT
<213> Homo sapiens

<400> 1
Asp Leu Glu Arg Val Phe Ile Trp Asp Leu Asp Glu Thr Ile Ile Val
 1               5                  10                  15      
Phe His Ser Leu Leu Thr Gly Ser Tyr Ala Ser Arg Tyr Gly Arg Asp
            20                  25                  30          
Pro Pro Thr Ser Val Ser Leu Gly Leu Arg Met Glu Glu Met Ile Phe
        35                  40                  45              
Asn Leu Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp
    50                  55                  60                  
Gln Val His Ile Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu
65                  70                  75                  80  
Ser Thr Tyr Asn Phe Gly Thr Asp Gly Phe Pro Ala Ala Ala Thr Ser
                85                  90                  95      
Ala Asn Leu Cys Leu Ala Thr Gly Val Arg Gly Gly Val Asp Trp Met
            100                 105                 110         
Arg Lys Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Ile Tyr Asn Thr
        115                 120                 125             
Tyr Lys Asn Asn Val Gly Gly Leu Leu Gly Pro Ala Lys Arg Glu Ala
    130                 135                 140                 
Trp Leu Gln Leu Arg Ala Glu Ile Glu Ala Leu Thr Asp Ser Trp Leu
145                 150                 155                 160 
Thr Leu Ala Leu Lys Ala Leu Ser Leu Ile His Ser Arg Thr Asn Cys
                165                 170                 175     
Val Asn Ile Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys
            180                 185                 190         
Val Leu Leu Tyr Gly Leu Gly Ile Val Phe Pro Ile Glu Asn Ile Tyr
        195                 200                 205             
Ser Ala Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Ile Gln
    210                 215                 220                 
Arg Phe Gly Arg Lys Val Val Tyr Val Val Ile Gly Asp Gly Val Glu
225                 230                 235                 240 
Glu Glu Gln Gly Ala Lys Lys His Ala Met Pro Phe Trp Arg Ile Ser
                245                 250                 255     
Ser His Ser Asp Leu Met Ala Leu His His Ala Leu Glu Leu Glu Tyr
            260                 265                 270         
Leu
    


<210> 2
<211> 273
<212> PRT
<213> Homo sapiens

<400> 2
Glu Ile Glu Arg Val Phe Val Trp Asp Leu Asp Glu Thr Ile Ile Ile
 1               5                  10                  15      
Phe His Ser Leu Leu Thr Gly Thr Phe Ala Ser Arg Tyr Gly Lys Asp
            20                  25                  30          
Thr Thr Thr Ser Val Arg Ile Gly Leu Met Met Glu Glu Met Ile Phe
        35                  40                  45              
Asn Leu Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Asp Cys Asp
    50                  55                  60                  
Gln Ile His Val Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu
65                  70                  75                  80  
Ser Thr Tyr Asn Phe Ser Ala Asp Gly Phe His Ser Ser Ala Pro Gly
                85                  90                  95      
Ala Asn Leu Cys Leu Gly Ser Gly Val His Gly Gly Val Asp Trp Met
            100                 105                 110         
Arg Lys Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Met Tyr Asn Thr
        115                 120                 125             
Tyr Lys Asn Asn Val Gly Gly Leu Ile Gly Thr Pro Lys Arg Glu Thr
    130                 135                 140                 
Trp Leu Gln Leu Arg Ala Glu Leu Glu Ala Leu Thr Asp Leu Trp Leu
145                 150                 155                 160 
Thr His Ser Leu Lys Ala Leu Asn Leu Ile Asn Ser Arg Pro Asn Cys
                165                 170                 175     
Val Asn Val Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys
            180                 185                 190         
Val Leu Leu Tyr Gly Leu Gly Ser Val Phe Pro Ile Glu Asn Ile Tyr
        195                 200                 205             
Ser Ala Thr Lys Thr Gly Lys Glu Ser Cys Phe Glu Arg Ile Met Gln
    210                 215                 220                 
Arg Phe Gly Arg Lys Ala Val Tyr Val Val Ile Gly Asp Gly Val Glu
225                 230                 235                 240 
Glu Glu Gln Gly Ala Lys Lys His Asn Met Pro Phe Trp Arg Ile Ser
                245                 250                 255     
Cys His Ala Asp Leu Glu Ala Leu Arg His Ala Leu Glu Leu Glu Tyr
            260                 265                 270         
Leu
    


<210> 3
<211> 273
<212> PRT
<213> Homo sapiens

<400> 3
Glu Leu Glu Arg Val Phe Leu Trp Asp Leu Asp Glu Thr Ile Ile Ile
 1               5                  10                  15      
Phe His Ser Leu Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp
            20                  25                  30          
Pro Thr Val Val Ile Gly Ser Gly Leu Thr Met Glu Glu Met Ile Phe
        35                  40                  45              
Glu Val Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp
    50                  55                  60                  
Gln Val His Val Glu Asp Val Ala Ser Asp Asp Asn Gly Gln Asp Leu
65                  70                  75                  80  
Ser Asn Tyr Ser Phe Ser Thr Asp Gly Phe Ser Gly Ser Gly Gly Ser
                85                  90                  95      
Gly Ser His Gly Ser Ser Val Gly Val Gln Gly Gly Val Asp Trp Met
            100                 105                 110         
Arg Lys Leu Ala Phe Arg Tyr Arg Lys Val Arg Glu Ile Tyr Asp Lys
        115                 120                 125             
His Lys Ser Asn Val Gly Gly Leu Leu Ser Pro Gln Arg Lys Glu Ala
    130                 135                 140                 
Leu Gln Arg Leu Arg Ala Glu Ile Glu Val Leu Thr Asp Ser Trp Leu
145                 150                 155                 160 
Gly Thr Ala Leu Lys Ser Leu Leu Leu Ile Gln Ser Arg Lys Asn Cys
                165                 170                 175     
Val Asn Val Leu Ile Thr Thr Thr Gln Leu Val Pro Ala Leu Ala Lys
            180                 185                 190         
Val Leu Leu Tyr Gly Leu Gly Glu Ile Phe Pro Ile Glu Asn Ile Tyr
        195                 200                 205             
Ser Ala Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Val Ser
    210                 215                 220                 
Arg Phe Gly Lys Lys Val Thr Tyr Val Val Ile Gly Asp Gly Arg Asp
225                 230                 235                 240 
Glu Glu Ile Ala Ala Lys Gln His Asn Met Pro Phe Trp Arg Ile Thr
                245                 250                 255     
Asn His Gly Asp Leu Val Ser Leu His Gln Ala Leu Glu Leu Asp Phe
            260                 265                 270         
Leu
    


<210> 4
<211> 273
<212> PRT
<213> Homo sapiens

<400> 4
Asp Leu Glu Arg Val Phe Val Trp Asp Leu Asp Glu Thr Ile Ile Val
 1               5                  10                  15      
Phe His Ser Leu Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp
            20                  25                  30          
Pro Pro Met Ala Val Thr Leu Gly Leu Arg Met Glu Glu Met Ile Phe
        35                  40                  45              
Asn Leu Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp
    50                  55                  60                  
Gln Val His Ile Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu
65                  70                  75                  80  
Ser Thr Tyr Ser Phe Ala Thr Asp Gly Phe His Ala Ala Ala Ser Ser
                85                  90                  95      
Ala Asn Leu Cys Leu Pro Thr Gly Val Arg Gly Gly Val Asp Trp Met
            100                 105                 110         
Arg Lys Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Leu Tyr Asn Thr
        115                 120                 125             
Tyr Lys Asn Asn Val Gly Gly Leu Leu Gly Pro Ala Lys Arg Asp Ala
    130                 135                 140                 
Trp Leu Gln Leu Arg Ala Glu Ile Glu Gly Leu Thr Asp Ser Trp Leu
145                 150                 155                 160 
Thr Asn Ala Leu Lys Ser Leu Ser Ile Ile Ser Thr Arg Ser Asn Cys
                165                 170                 175     
Ile Asn Val Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys
            180                 185                 190         
Val Leu Leu Tyr Ser Leu Gly Gly Ala Phe Pro Ile Glu Asn Ile Tyr
        195                 200                 205             
Ser Ala Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Met Gln
    210                 215                 220                 
Arg Phe Gly Arg Lys Val Val Tyr Val Val Ile Gly Asp Gly Val Glu
225                 230                 235                 240 
Glu Glu Gln Ala Ala Lys Lys His Asn Met Pro Phe Trp Arg Ile Ser
                245                 250                 255     
Ser His Ser Asp Leu Leu Ala Leu His Gln Ala Leu Glu Leu Glu Tyr
            260                 265                 270         
Leu
    


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Artificially synthesized peptide

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = O-Phosphotyrosine

<400> 5
Lys Lys Ala Thr Gln Ala Ser Gln Glu Xaa
 1               5                  10  

