                         SEQUENCE LISTING

<110>  Brandeis University
       Suzanne, Paradis
       Anna, Moore R.
       Marissa, Kuzirian S.
 
<120>  METHODS OF MODULATING GABAERGIC INHIBITORY SYNAPSE FORMATION AND 
       FUNCTION

<130>  43022.0121

<150>  61/756,809
<151>  2013-01-25

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca       60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcacctggtg      120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac      180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag      240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag      300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc      360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta      420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca      480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat      540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa      600

tatgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgacgtgat ccgaaaaagc      660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg      720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtgtg caagggggac      780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc      840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg      900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg      960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg     1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc     1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac     1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg     1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tgtgaactac     1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt     1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc     1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca     1440

aagaagggca acaggtttgt ctatgctggc tctaactcgg gcgtggtcca ggccccgctg     1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc     1560

gcctggagcc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg     1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggataaaag taaaggaagt     1680

taccggcagc attttttcaa gcacggtggc acagcggaac tgaaatgctc ccaaaaatcc     1740

aacctggccc gggtcttttg gaagttccag aatggcgtgt tgaaggccga gagccccaag     1800

tacggtctta tgggcagaaa aaacttgctc atcttcaact tgtcagaagg agacagtggg     1860

gtgtaccagt gcctgtcaga ggagagggtt aagaacaaaa cggtcttcca agtggtcgcc     1920

aagcacgtcc tggaagtgaa ggtggttcca aagcccgtag tggcccccac cttgtcagtt     1980

gttcagacag aaggtagtag gattgccacc aaagtgttgg tggcatccac ccaagggtct     2040

tctcccccaa ccccagccgt gcaggccacc tcctccgggg ccatcaccct tcctcccaag     2100

cctgcgccca ccggcacatc ctgcgaacca aagatcgtca tcaacacggt cccccagctc     2160

cactcggaga aaaccatgta tcttaagtcc agcgacaacc gcctcctcat gtccctcttc     2220

ctcttcttct ttgttctctt cctctgcctc tttttctaca actgctataa gggatacctg     2280

cccagacagt gcttgaaatt ccgctcggcc ctactaattg ggaagaagaa gcccaagtca     2340

gatttctgtg accgtgagca gagcctgaag gagacgttag tagagccagg gagcttctcc     2400

cagcagaatg gggagcaccc caagccagcc ctggacaccg gctatgagac cgagcaagac     2460

accatcacca gcaaagtccc cacggatagg gaggactcac agaggatcga cgacctttct     2520

gccagggaca agccctttga cgtcaagtgt gagctgaagt tcgctgactc agacgcagat     2580

ggagactga                                                             2589


<210>  2
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Phe Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  3
<211>  2217
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca       60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcacctggtg      120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac      180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag      240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag      300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc      360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta      420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca      480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat      540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa      600

tatgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgacgtgat ccgaaaaagc      660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg      720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtgtg caagggggac      780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc      840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg      900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg      960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg     1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc     1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac     1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg     1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tgtgaactac     1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt     1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc     1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca     1440

aagaagggca acaggtttgt ctatgctggc tctaactcgg gcgtggtcca ggccccgctg     1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc     1560

gcctggagcc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg     1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggcctcgtc tcctaagccc     1680

ctccctcctc ctggctcctc ttccctgtcc tgtctgggcc atgtggggga caggaggctt     1740

tcctctccct ggaccccctg gccagcctcg ggtgcggggc ccgacagcag ctcgagggtc     1800

tccttgctgc cgcccttcct gagtgaccag gcacagcacg tgcacgccct ggggaacttc     1860

tacctcttct gccaggccac aggtcctgca gacattcgct ttgtctggga gaagaatggg     1920

cgagctctgg agacctgtgt ccctgtgcag acccatgcac tgcccgatgg cagggcccat     1980

gcactcagct ggctgcagga cgccatcagg gaaagcgctg agtatcgctg ctctgtcctc     2040

tcctcagcag ggaacaagac ttcgaaggtg caggttgctg tgatgagacc tgaagtgacc     2100

caccaggaga ggtggaccag agagctctct gcctggaggg ctgtggctgg ggagcacgac     2160

cggatgatgc agagctggag gaaggcgtgg gaaagctgta gcaaggacac cctgtag        2217


<210>  4
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val His Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Ala Ser Ser Pro Lys Pro 
545                 550                 555                 560 


Leu Pro Pro Pro Gly Ser Ser Ser Leu Ser Cys Leu Gly His Val Gly 
                565                 570                 575     


Asp Arg Arg Leu Ser Ser Pro Trp Thr Pro Trp Pro Ala Ser Gly Ala 
            580                 585                 590         


Gly Pro Asp Ser Ser Ser Arg Val Ser Leu Leu Pro Pro Phe Leu Ser 
        595                 600                 605             


Asp Gln Ala Gln His Val His Ala Leu Gly Asn Phe Tyr Leu Phe Cys 
    610                 615                 620                 


Gln Ala Thr Gly Pro Ala Asp Ile Arg Phe Val Trp Glu Lys Asn Gly 
625                 630                 635                 640 


Arg Ala Leu Glu Thr Cys Val Pro Val Gln Thr His Ala Leu Pro Asp 
                645                 650                 655     


Gly Arg Ala His Ala Leu Ser Trp Leu Gln Asp Ala Ile Arg Glu Ser 
            660                 665                 670         


Ala Glu Tyr Arg Cys Ser Val Leu Ser Ser Ala Gly Asn Lys Thr Ser 
        675                 680                 685             


Lys Val Gln Val Ala Val Met Arg Pro Glu Val Thr His Gln Glu Arg 
    690                 695                 700                 


Trp Thr Arg Glu Leu Ser Ala Trp Arg Ala Val Ala Gly Glu His Asp 
705                 710                 715                 720 


Arg Met Met Gln Ser Trp Arg Lys Ala Trp Glu Ser Cys Ser Lys Asp 
                725                 730                 735     


Thr Leu 
        


<210>  5
<211>  2586
<212>  DNA
<213>  Mus musculus

<400>  5
atgaggatgt gtgcccccgt tagggggctg ttcttggccc tggtggtagt gttgagaacc       60

gcggtggcat ttgcacctgt gcctcggctc acctgggaac atggagaggt aggtctggtg      120

cagtttcaca agccaggcat ctttaactac tcggccttgc tgatgagtga ggacaaagac      180

actctgtatg taggcgcccg ggaagcagtc tttgcagtga atgcgctgaa catctctgag      240

aagcaacatg aggtatattg gaaggtctct gaagacaaaa aatccaagtg tgcagagaag      300

gggaaatcaa agcagacgga atgcctaaac tacattcgag tactacagcc actaagcagc      360

acttccctct atgtgtgtgg gaccaatgcg ttccagccca cctgtgacca cctgaacttg      420

acatccttca agtttctggg gaaaagtgaa gatggcaaag gaagatgccc cttcgacccc      480

gcccacagct acacatcagt catggttggg ggcgagctct actctgggac gtcctataat      540

ttcttgggca gtgaacccat catctctcga aactcttccc acagtccctt gaggacggag      600

tatgccatcc cgtggctgaa cgagcctagc ttcgtctttg ctgacgtgat ccagaaaagc      660

ccagatggtc cggagggtga agatgacaag gtctacttct tttttacgga ggtatccgtg      720

gagtacgaat tcgtcttcaa gttgatgatc ccgcgagttg ccagggtgtg caagggcgac      780

cagggcggcc tgcggacttt gcaaaaaaag tggacctcct tcctaaaggc caggctgatc      840

tgctccaagc cagacagtgg cctggtcttc aacatacttc aggatgtgtt tgtgctgagg      900

gccccgggcc tcaaggagcc tgtgttctat gcggtcttca ccccacagct gaacaatgtg      960

ggtctgtcag cggtgtgcgc ctacacactg gccacggtgg aggcagtctt ctcccgtgga     1020

aagtacatgc agagtgccac agtggagcag tctcacacca agtgggtgcg ctacaatggc     1080

ccagtgccca ctccccgacc tggagcgtgt atcgacagtg aggcccgggc agccaactac     1140

accagctcct tgaatctccc agacaaaaca ctgcagtttg taaaagacca ccctttgatg     1200

gatgactcag tgaccccgat agacaacaga cccaagctga tcaaaaaaga tgtaaactac     1260

acccagatag tggtagacag gacccaggcc ctggatggga ctttctacga cgtcatgttc     1320

atcagcacag accggggagc tctgcataaa gcagtcatcc tcacaaaaga ggtgcatgtc     1380

atcgaggaga cccaactctt ccgggactct gaaccggtcc taactctgct gctatcgtca     1440

aagaagggga ggaagtttgt ctatgcaggc tccaactctg gagtggtcca agcgcccctg     1500

gcattctgcg aaaagcacgg tagctgtgaa gactgtgtgt tagcacggga cccctactgt     1560

gcctggagcc cagccatcaa ggcctgtgtt accctgcacc aggaagaggc ctccagcagg     1620

ggctggattc aggacatgag cggtgacaca tcctcatgcc tggataagag taaagaaagt     1680

ttcaaccagc attttttcaa gcacggcggc acagcggaac tcaaatgttt ccaaaagtcc     1740

aacctagccc gggtggtatg gaagttccag aatggcgagt tgaaggccgc aagtcccaag     1800

tacggctttg tgggcaggaa gcacctgctc atcttcaacc tgtcggacgg agacagcggc     1860

gtgtaccagt gcctgtcaga ggaaagggtg aggaataaaa cggtctccca gctgctggcc     1920

aagcacgttc tggaagtgaa gatggtacct cggacccccc cctcacctac ctcagaggat     1980

gctcagacag aaggtagtaa gatcacatcc aaaatgccgg ttgcatctac ccaggggtcc     2040

tctcccccta ccccggctct gtgggcaacc tcccccagag ccgccaccct acctcccaag     2100

tcctcctccg gcacatcctg tgaaccaaag atggtcatca acacggtccc ccagctccac     2160

tcagagaaga cggtgtatct caagtccagt gacaaccgcc tgctcatgtc tctcctcctc     2220

ttcatctttg tcctcttcct ctgcctcttt tcctacaact gctacaaggg ctacctgccc     2280

ggacagtgct taaaattccg ctcagccctg ctgcttggaa agaaaacacc caagtcagac     2340

ttctctgacc tggagcagag tgtgaaggag acactggtcg agcctgggag cttctcccag     2400

cagaacggcg accaccccaa gccagccctg gatacgggct atgaaacgga gcaggacacc     2460

atcaccagca aagtccccac ggatcgtgag gactcgcaac ggatcgatga actctctgcc     2520

cgggacaaac cgtttgatgt caagtgtgaa ctgaagtttg cagattcgga tgctgacggg     2580

gactga                                                                2586


<210>  6
<211>  861
<212>  PRT
<213>  Mus musculus

<400>  6

Met Arg Met Cys Ala Pro Val Arg Gly Leu Phe Leu Ala Leu Val Val 
1               5                   10                  15      


Val Leu Arg Thr Ala Val Ala Phe Ala Pro Val Pro Arg Leu Thr Trp 
            20                  25                  30          


Glu His Gly Glu Val Gly Leu Val Gln Phe His Lys Pro Gly Ile Phe 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Met Ser Glu Asp Lys Asp Thr Leu Tyr Val 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ser Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ser Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Thr Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Ser Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Gly Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Gln Lys Ser Pro Asp Gly Pro 
    210                 215                 220                 


Glu Gly Glu Asp Asp Lys Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Lys Leu Met Ile Pro Arg Val Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Lys Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Ile Leu Gln Asp Val Phe Val Leu Arg Ala Pro Gly Leu 
    290                 295                 300                 


Lys Glu Pro Val Phe Tyr Ala Val Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Thr Leu Ala Thr Val Glu Ala Val 
                325                 330                 335     


Phe Ser Arg Gly Lys Tyr Met Gln Ser Ala Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Thr Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Lys Leu Ile Lys Lys 
                405                 410                 415     


Asp Val Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Phe Tyr Asp Val Met Phe Ile Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Val Ile Leu Thr Lys Glu Val His Val Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Arg Asp Ser Glu Pro Val Leu Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Arg Lys Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Glu Lys His Gly Ser Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Ala Ile Lys Ala 
        515                 520                 525             


Cys Val Thr Leu His Gln Glu Glu Ala Ser Ser Arg Gly Trp Ile Gln 
    530                 535                 540                 


Asp Met Ser Gly Asp Thr Ser Ser Cys Leu Asp Lys Ser Lys Glu Ser 
545                 550                 555                 560 


Phe Asn Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Phe Gln Lys Ser Asn Leu Ala Arg Val Val Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Glu Leu Lys Ala Ala Ser Pro Lys Tyr Gly Phe Val Gly Arg Lys His 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Asp Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Arg Asn Lys Thr Val Ser Gln Leu Leu Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Met Val Pro Arg Thr Pro Pro Ser Pro 
                645                 650                 655     


Thr Ser Glu Asp Ala Gln Thr Glu Gly Ser Lys Ile Thr Ser Lys Met 
            660                 665                 670         


Pro Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Leu Trp 
        675                 680                 685             


Ala Thr Ser Pro Arg Ala Ala Thr Leu Pro Pro Lys Ser Ser Ser Gly 
    690                 695                 700                 


Thr Ser Cys Glu Pro Lys Met Val Ile Asn Thr Val Pro Gln Leu His 
705                 710                 715                 720 


Ser Glu Lys Thr Val Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu Met 
                725                 730                 735     


Ser Leu Leu Leu Phe Ile Phe Val Leu Phe Leu Cys Leu Phe Ser Tyr 
            740                 745                 750         


Asn Cys Tyr Lys Gly Tyr Leu Pro Gly Gln Cys Leu Lys Phe Arg Ser 
        755                 760                 765             


Ala Leu Leu Leu Gly Lys Lys Thr Pro Lys Ser Asp Phe Ser Asp Leu 
    770                 775                 780                 


Glu Gln Ser Val Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser Gln 
785                 790                 795                 800 


Gln Asn Gly Asp His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu Thr 
                805                 810                 815     


Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp Ser 
            820                 825                 830         


Gln Arg Ile Asp Glu Leu Ser Ala Arg Asp Lys Pro Phe Asp Val Lys 
        835                 840                 845             


Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860     


<210>  7
<211>  2583
<212>  DNA
<213>  Rattus norvegicus

<400>  7
atgaagatgt gtgcccccgt cagggggctg ttcttggccc tggtggctgt gtggaggacc       60

gcggtggcat tcgcccctgt gcctcggatc acctgggagc acggagaggt aggtctggtg      120

aaccttcacg agccaggcat ctttaactac tcttccttgc tgatgacaag ccacaaggat      180

cctcctgtct ctgcctcccc aattggggct gcagtgaacc ggctctgaca tgttcccccc      240

tcacaggtat actggaaggt ctctgaagac aaaaaatcca agtgcgcaga gaaggggaaa      300

tcaaagcaga cggagtgcct taactacatc cgagtgctgc aaccgcttag cagcacttcc      360

ctctacgtgt gtgggaccaa tgcgttccag cccacctgtg accacctgaa cttgacctct      420

ttcaagtttc tggggaaaag cgaagatggc aaaggaagat gccccttcga ccccgcccat      480

agctacacat ccgtcatggt cgggggagag ctctactctg ggacttcata taatttcttg      540

ggcagcgaac ccatcatctc tcgaaactct tcccacagtc ccctgaggac agagtacgcc      600

atcccttggc taaacgagcc tagcttcgtc tttgctgacg tgatccacaa gagcccagat      660

ggtacagagg ctgaggatga caaggtctac ttcttcttta cggaggtgtc cgtggagtac      720

gagttcgtct tcaagttgat gatcccgcga gttgccaggg tgtgcaaggg cgaccagggc      780

ggcctgcgga ctttgcaaaa aaagtggacc tccttcctaa aggccagact gatctgctcc      840

aggccagaca gtggcctggt cttcaacatt cttcaagatg tgtttgtgct gagggccccg      900

ggcctcaagg aacctgtgtt ctatgcggtc ttcaccccac agctgaacaa cgtgggtctg      960

tcagcggtct gtgcctacac gctgtccacg gtggaggccg tcttctcccg aggaaagtac     1020

atgcagagtg ccacagtgga gcagtctcac accaagtggg tacgctacaa tggcccagtg     1080

cccactcccc ggcctggagc gtgtatcgac agtgaggccc gggcagccaa ctacaccagc     1140

tccttgaatc tcccagacaa aacgctgcag tttgtcaaag accacccttt gatggacgac     1200

tcggtgacgc caatagacaa caggccgaaa ctgatcaaaa aagatgtcaa ctacacccag     1260

atagtggtag acaggaccca ggccctggat gggaccttct acgacgtcat gttcctcagc     1320

acagaccggg gcgctctgca taaagctgtc atccttgcaa aagaggtaca cgtggttgag     1380

gagacccaac tcttccagga cttcgaaccg gtcctgtctc tgctgctatc atcaaagaag     1440

gggaggaagt ttgtctatgc tggctccaac tcaggagtgg tccaagctcc cctggccttc     1500

tgcggaaagc acagtagctg tgaagactgt gtgctagcac gggaccccta ctgcgcctgg     1560

agcccagcca tcaaggcctg tgttaccttg caccaggcag agggctctag caggggctgg     1620

attcaggaca tgagtggcga cacgtcctcg tgcctggata agagtaaaga aagtttccat     1680

cagcattttt tcaagcacgg cggcacagca gaactcaagt gtttccaaaa gtccaacctg     1740

gcccgggtgg tgtggaagtt ccagaacggc gagttgaagg ctgtgagtcc caagtatggc     1800

tttgtgggca ggaagcacct gctcatcttt aacctgtcag acggagacag cggtgtgtac     1860

cagtgcctgt cagaggaaag ggtcaggaat aaaacggtct cccagctgct cgccaagcac     1920

atcctggaag tgaaaatggt agctcggatc cccccatcac ctacctcaca gactgctcag     1980

acagaaggta gtaggatcac atccaaaatg cctgtggcgt ctacccaggg gtcctctccc     2040

cctaccccgg ctctgtgggc aacctccccc agggctgcca ccctacctcc caagtcctcc     2100

tccaccggca cgtcctgtga accaaaaatg gtcatcaaca cggtcccaca gctccactcg     2160

gagaagacag tgtatctcaa gtccagtgac aaccgcctgc tcatgtctct cctcctcttc     2220

ctctttgtcc tcttcctctg cctcttttcc tacaactgct acaagggcta cctgcccgga     2280

cagtgcttaa agttccgctc agccctgctg ctcgcaaaga aaaaacccaa gtcagagttc     2340

tctgacctgg agcagagtgt gaaggagacg ctggtagaac ctgggagctt ctcgcagcag     2400

aacggcgacc agcccaagcc agccttggat accggctatg aaaccgagca ggacactatc     2460

accagcaagg tccccaccga tcgagaggac tcgcaacgta tcgacgagct ctccgccagg     2520

gacaaaccgt ttgatgtcaa gtgtgaactc aagtttgcag actcggatgc cgacggggac     2580

tga                                                                   2583


<210>  8
<211>  860
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Met Lys Met Cys Ala Pro Val Arg Gly Leu Phe Leu Ala Leu Val Ala 
1               5                   10                  15      


Val Trp Arg Thr Ala Val Ala Phe Ala Pro Val Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Gly Glu Val Gly Leu Val Asn Leu His Glu Pro Gly Ile Phe 
        35                  40                  45              


Asn Tyr Ser Ser Leu Leu Met Thr Ser His Lys Asp Pro Pro Val Ser 
    50                  55                  60                  


Ala Ser Pro Ile Gly Ala Ala Val Asn Arg Leu Xaa His Val Pro Pro 
65                  70                  75                  80  


Ser Gln Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ser Lys Cys Ala 
                85                  90                  95      


Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile Arg Val 
            100                 105                 110         


Leu Gln Pro Leu Ser Ser Thr Ser Leu Tyr Val Cys Gly Thr Asn Ala 
        115                 120                 125             


Phe Gln Pro Thr Cys Asp His Leu Asn Leu Thr Ser Phe Lys Phe Leu 
    130                 135                 140                 


Gly Lys Ser Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro Ala His 
145                 150                 155                 160 


Ser Tyr Thr Ser Val Met Val Gly Gly Glu Leu Tyr Ser Gly Thr Ser 
                165                 170                 175     


Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser Ser His 
            180                 185                 190         


Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu Pro Ser 
        195                 200                 205             


Phe Val Phe Ala Asp Val Ile His Lys Ser Pro Asp Gly Thr Glu Ala 
    210                 215                 220                 


Glu Asp Asp Lys Val Tyr Phe Phe Phe Thr Glu Val Ser Val Glu Tyr 
225                 230                 235                 240 


Glu Phe Val Phe Lys Leu Met Ile Pro Arg Val Ala Arg Val Cys Lys 
                245                 250                 255     


Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr Ser Phe 
            260                 265                 270         


Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu Val Phe 
        275                 280                 285             


Asn Ile Leu Gln Asp Val Phe Val Leu Arg Ala Pro Gly Leu Lys Glu 
    290                 295                 300                 


Pro Val Phe Tyr Ala Val Phe Thr Pro Gln Leu Asn Asn Val Gly Leu 
305                 310                 315                 320 


Ser Ala Val Cys Ala Tyr Thr Leu Ser Thr Val Glu Ala Val Phe Ser 
                325                 330                 335     


Arg Gly Lys Tyr Met Gln Ser Ala Thr Val Glu Gln Ser His Thr Lys 
            340                 345                 350         


Trp Val Arg Tyr Asn Gly Pro Val Pro Thr Pro Arg Pro Gly Ala Cys 
        355                 360                 365             


Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu Asn Leu 
    370                 375                 380                 


Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met Asp Asp 
385                 390                 395                 400 


Ser Val Thr Pro Ile Asp Asn Arg Pro Lys Leu Ile Lys Lys Asp Val 
                405                 410                 415     


Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp Gly Thr 
            420                 425                 430         


Phe Tyr Asp Val Met Phe Leu Ser Thr Asp Arg Gly Ala Leu His Lys 
        435                 440                 445             


Ala Val Ile Leu Ala Lys Glu Val His Val Val Glu Glu Thr Gln Leu 
    450                 455                 460                 


Phe Gln Asp Phe Glu Pro Val Leu Ser Leu Leu Leu Ser Ser Lys Lys 
465                 470                 475                 480 


Gly Arg Lys Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val Gln Ala 
                485                 490                 495     


Pro Leu Ala Phe Cys Gly Lys His Ser Ser Cys Glu Asp Cys Val Leu 
            500                 505                 510         


Ala Arg Asp Pro Tyr Cys Ala Trp Ser Pro Ala Ile Lys Ala Cys Val 
        515                 520                 525             


Thr Leu His Gln Ala Glu Gly Ser Ser Arg Gly Trp Ile Gln Asp Met 
    530                 535                 540                 


Ser Gly Asp Thr Ser Ser Cys Leu Asp Lys Ser Lys Glu Ser Phe His 
545                 550                 555                 560 


Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys Phe Gln 
                565                 570                 575     


Lys Ser Asn Leu Ala Arg Val Val Trp Lys Phe Gln Asn Gly Glu Leu 
            580                 585                 590         


Lys Ala Val Ser Pro Lys Tyr Gly Phe Val Gly Arg Lys His Leu Leu 
        595                 600                 605             


Ile Phe Asn Leu Ser Asp Gly Asp Ser Gly Val Tyr Gln Cys Leu Ser 
    610                 615                 620                 


Glu Glu Arg Val Arg Asn Lys Thr Val Ser Gln Leu Leu Ala Lys His 
625                 630                 635                 640 


Ile Leu Glu Val Lys Met Val Ala Arg Ile Pro Pro Ser Pro Thr Ser 
                645                 650                 655     


Gln Thr Ala Gln Thr Glu Gly Ser Arg Ile Thr Ser Lys Met Pro Val 
            660                 665                 670         


Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Leu Trp Ala Thr 
        675                 680                 685             


Ser Pro Arg Ala Ala Thr Leu Pro Pro Lys Ser Ser Ser Thr Gly Thr 
    690                 695                 700                 


Ser Cys Glu Pro Lys Met Val Ile Asn Thr Val Pro Gln Leu His Ser 
705                 710                 715                 720 


Glu Lys Thr Val Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu Met Ser 
                725                 730                 735     


Leu Leu Leu Phe Leu Phe Val Leu Phe Leu Cys Leu Phe Ser Tyr Asn 
            740                 745                 750         


Cys Tyr Lys Gly Tyr Leu Pro Gly Gln Cys Leu Lys Phe Arg Ser Ala 
        755                 760                 765             


Leu Leu Leu Ala Lys Lys Lys Pro Lys Ser Glu Phe Ser Asp Leu Glu 
    770                 775                 780                 


Gln Ser Val Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser Gln Gln 
785                 790                 795                 800 


Asn Gly Asp Gln Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu Thr Glu 
                805                 810                 815     


Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp Ser Gln 
            820                 825                 830         


Arg Ile Asp Glu Leu Ser Ala Arg Asp Lys Pro Phe Asp Val Lys Cys 
        835                 840                 845             


Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860 


<210>  9
<211>  2589
<212>  DNA
<213>  Pan troglodytes

<400>  9
atgaggatgt gcacccccat tagggggctg ctcatggccc ttgcagtgat gtttgggaca       60

gcgatggcat ttgcacccat accccggatc acctgggagc acagagaggt gcgcctggtg      120

cagtttcatg agccagacat ctacaactac tcagccttgc tgctgagcga ggacaaggac      180

accttgtaca taggtgcccg ggaggcggtc ttcgctgtga acgcactcaa catctccgag      240

aagcagcatg aggtgtattg gaaggtctca gaagacaaaa aagcaaaatg tgcagaaaag      300

gggaaatcaa aacagacaga gtgcctcaac tacatccggg tgctgcagcc actcagcgcc      360

acttcccttt acgtgtgtgg gaccaacgca ttccagccgg cctgtgacca cctgaactta      420

acatccttta agtttctggg gaaaaatgaa gatggcaaag gaagatgtcc ctttgaccca      480

gcacacagct acacatccgt catggttgat ggagaacttt attcggggac gtcgtataat      540

tttttgggaa gtgaacccat catctcccga aattcttccc acagtcctct gaggacagaa      600

tacgcaatcc cttggctgaa cgagcctagt ttcgtgtttg ctgatgtgat ccgaaaaagc      660

ccagacagcc ccgacggcga ggatgacagg gtctacttct tcttcacgga ggtgtctgtg      720

gagtatgagt ttgtgttcag ggtgctgatc ccacggatag caagagtatg caagggggac      780

cagggcggcc tgaggacctt gcagaagaaa tggacctcct tcctgaaagc ccgactcatc      840

tgctcccggc cagacagcgg cttggtcttc aatgtgctgc gggatgtctt cgtgctcagg      900

tccccgggcc tgaaggtgcc tgtgttctat gcactcttca ccccacagct gaacaacgtg      960

gggctgtcgg cagtgtgcgc ctacaacctg tccacagccg aggaggtctt ctcccacggg     1020

aagtacatgc agagcaccac agtggagcag tcccacacca agtgggtgcg ctataatggc     1080

ccggtaccca agccgcggcc tggagcgtgc atcgacagcg aggcacgggc cgccaactac     1140

accagctcct tgaatttgcc agacaagacg ctgcagttcg ttaaagacca ccctttgatg     1200

gatgactcgg taaccccaat agacaacagg cccaggttaa tcaagaaaga tatgaactac     1260

acccagatcg tggtggaccg gacccaggcc ctggatggga ctgtctatga tgtcatgttt     1320

gtcagcacag accggggagc tctgcacaaa gccatcagcc tcgagcacgc tgttcacatc     1380

atcgaggaga cccagctctt ccaggacttt gagccagtcc agaccctgct gctgtcttca     1440

aagaagggca acaggtttgt ctatgctggc tccaactcgg gcgtggtcca ggccccgctg     1500

gccttctgtg ggaagcacgg cacctgcgag gactgtgtgc tggcgcggga cccctactgc     1560

gcctggaacc cgcccacagc gacctgcgtg gctctgcacc agaccgagag ccccagcagg     1620

ggtttgattc aggagatgag cggcgatgct tctgtgtgcc cggataaaag taaaggaagt     1680

taccggcagc attttttcaa gcacggtggc acagcggaac tgaaatgctc ccaaaaatcc     1740

aacctggccc gggtcttttg gaagttccag aatggcgtgt tgaaggccga gagccccaag     1800

tacggtctta tgggcagaaa aaacttgctc atcttcaact tgtcagaagg agacagtggg     1860

gtgtaccagt gcctgtcaga ggagagggtt aagaacaaaa cggtcttcca agtggtcgcc     1920

aagcacgtcc tggaagtgaa ggtggttcca aagcccgtag tggcccccac cttgtcagtt     1980

gttcagacag aaggtagtag gattgccacc aaagtgttgg tggcatccac ccaagggtct     2040

tctcccccaa ccccagccgt gcaggccacc tcctccgggg ccatcaccct tcctcccaag     2100

cctgcgccca ctggcacatc ctgcgaacca aagatcgtca tcaacacggt cccccagctc     2160

cactcggaga aaaccatgta tcttaagtcc agcgacaacc gcctcctcat gtccctcttc     2220

ctcctcttct ttgttctctt cctctgcctc tttttctaca actgctataa gggatacctg     2280

cccagacagt gcttgaaatt ccgctcggcc ctactaattg ggaagaagaa gcccaagtca     2340

gatttctgtg accgtgagca gagcctgaag gagacgttag tagagccagg gagcttctcc     2400

cagcagaatg gggagcaccc caagccagcc ctggacaccg gctatgagac cgagcaagac     2460

accatcacca gcaaagtccc cacggatagg gaggactcac agaggatcga cgacctttct     2520

gccagggaca agccctttga cgtcaagtgt gagctgaagt tcgctgactc agacgcagat     2580

ggagactga                                                             2589


<210>  10
<211>  862
<212>  PRT
<213>  Pan troglodytes

<400>  10

Met Arg Met Cys Thr Pro Ile Arg Gly Leu Leu Met Ala Leu Ala Val 
1               5                   10                  15      


Met Phe Gly Thr Ala Met Ala Phe Ala Pro Ile Pro Arg Ile Thr Trp 
            20                  25                  30          


Glu His Arg Glu Val Arg Leu Val Gln Phe His Glu Pro Asp Ile Tyr 
        35                  40                  45              


Asn Tyr Ser Ala Leu Leu Leu Ser Glu Asp Lys Asp Thr Leu Tyr Ile 
    50                  55                  60                  


Gly Ala Arg Glu Ala Val Phe Ala Val Asn Ala Leu Asn Ile Ser Glu 
65                  70                  75                  80  


Lys Gln His Glu Val Tyr Trp Lys Val Ser Glu Asp Lys Lys Ala Lys 
                85                  90                  95      


Cys Ala Glu Lys Gly Lys Ser Lys Gln Thr Glu Cys Leu Asn Tyr Ile 
            100                 105                 110         


Arg Val Leu Gln Pro Leu Ser Ala Thr Ser Leu Tyr Val Cys Gly Thr 
        115                 120                 125             


Asn Ala Phe Gln Pro Ala Cys Asp His Leu Asn Leu Thr Ser Phe Lys 
    130                 135                 140                 


Phe Leu Gly Lys Asn Glu Asp Gly Lys Gly Arg Cys Pro Phe Asp Pro 
145                 150                 155                 160 


Ala His Ser Tyr Thr Ser Val Met Val Asp Gly Glu Leu Tyr Ser Gly 
                165                 170                 175     


Thr Ser Tyr Asn Phe Leu Gly Ser Glu Pro Ile Ile Ser Arg Asn Ser 
            180                 185                 190         


Ser His Ser Pro Leu Arg Thr Glu Tyr Ala Ile Pro Trp Leu Asn Glu 
        195                 200                 205             


Pro Ser Phe Val Phe Ala Asp Val Ile Arg Lys Ser Pro Asp Ser Pro 
    210                 215                 220                 


Asp Gly Glu Asp Asp Arg Val Tyr Phe Phe Phe Thr Glu Val Ser Val 
225                 230                 235                 240 


Glu Tyr Glu Phe Val Phe Arg Val Leu Ile Pro Arg Ile Ala Arg Val 
                245                 250                 255     


Cys Lys Gly Asp Gln Gly Gly Leu Arg Thr Leu Gln Lys Lys Trp Thr 
            260                 265                 270         


Ser Phe Leu Lys Ala Arg Leu Ile Cys Ser Arg Pro Asp Ser Gly Leu 
        275                 280                 285             


Val Phe Asn Val Leu Arg Asp Val Phe Val Leu Arg Ser Pro Gly Leu 
    290                 295                 300                 


Lys Val Pro Val Phe Tyr Ala Leu Phe Thr Pro Gln Leu Asn Asn Val 
305                 310                 315                 320 


Gly Leu Ser Ala Val Cys Ala Tyr Asn Leu Ser Thr Ala Glu Glu Val 
                325                 330                 335     


Phe Ser His Gly Lys Tyr Met Gln Ser Thr Thr Val Glu Gln Ser His 
            340                 345                 350         


Thr Lys Trp Val Arg Tyr Asn Gly Pro Val Pro Lys Pro Arg Pro Gly 
        355                 360                 365             


Ala Cys Ile Asp Ser Glu Ala Arg Ala Ala Asn Tyr Thr Ser Ser Leu 
    370                 375                 380                 


Asn Leu Pro Asp Lys Thr Leu Gln Phe Val Lys Asp His Pro Leu Met 
385                 390                 395                 400 


Asp Asp Ser Val Thr Pro Ile Asp Asn Arg Pro Arg Leu Ile Lys Lys 
                405                 410                 415     


Asp Met Asn Tyr Thr Gln Ile Val Val Asp Arg Thr Gln Ala Leu Asp 
            420                 425                 430         


Gly Thr Val Tyr Asp Val Met Phe Val Ser Thr Asp Arg Gly Ala Leu 
        435                 440                 445             


His Lys Ala Ile Ser Leu Glu His Ala Val His Ile Ile Glu Glu Thr 
    450                 455                 460                 


Gln Leu Phe Gln Asp Phe Glu Pro Val Gln Thr Leu Leu Leu Ser Ser 
465                 470                 475                 480 


Lys Lys Gly Asn Arg Phe Val Tyr Ala Gly Ser Asn Ser Gly Val Val 
                485                 490                 495     


Gln Ala Pro Leu Ala Phe Cys Gly Lys His Gly Thr Cys Glu Asp Cys 
            500                 505                 510         


Val Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asn Pro Pro Thr Ala Thr 
        515                 520                 525             


Cys Val Ala Leu His Gln Thr Glu Ser Pro Ser Arg Gly Leu Ile Gln 
    530                 535                 540                 


Glu Met Ser Gly Asp Ala Ser Val Cys Pro Asp Lys Ser Lys Gly Ser 
545                 550                 555                 560 


Tyr Arg Gln His Phe Phe Lys His Gly Gly Thr Ala Glu Leu Lys Cys 
                565                 570                 575     


Ser Gln Lys Ser Asn Leu Ala Arg Val Phe Trp Lys Phe Gln Asn Gly 
            580                 585                 590         


Val Leu Lys Ala Glu Ser Pro Lys Tyr Gly Leu Met Gly Arg Lys Asn 
        595                 600                 605             


Leu Leu Ile Phe Asn Leu Ser Glu Gly Asp Ser Gly Val Tyr Gln Cys 
    610                 615                 620                 


Leu Ser Glu Glu Arg Val Lys Asn Lys Thr Val Phe Gln Val Val Ala 
625                 630                 635                 640 


Lys His Val Leu Glu Val Lys Val Val Pro Lys Pro Val Val Ala Pro 
                645                 650                 655     


Thr Leu Ser Val Val Gln Thr Glu Gly Ser Arg Ile Ala Thr Lys Val 
            660                 665                 670         


Leu Val Ala Ser Thr Gln Gly Ser Ser Pro Pro Thr Pro Ala Val Gln 
        675                 680                 685             


Ala Thr Ser Ser Gly Ala Ile Thr Leu Pro Pro Lys Pro Ala Pro Thr 
    690                 695                 700                 


Gly Thr Ser Cys Glu Pro Lys Ile Val Ile Asn Thr Val Pro Gln Leu 
705                 710                 715                 720 


His Ser Glu Lys Thr Met Tyr Leu Lys Ser Ser Asp Asn Arg Leu Leu 
                725                 730                 735     


Met Ser Leu Phe Leu Leu Phe Phe Val Leu Phe Leu Cys Leu Phe Phe 
            740                 745                 750         


Tyr Asn Cys Tyr Lys Gly Tyr Leu Pro Arg Gln Cys Leu Lys Phe Arg 
        755                 760                 765             


Ser Ala Leu Leu Ile Gly Lys Lys Lys Pro Lys Ser Asp Phe Cys Asp 
    770                 775                 780                 


Arg Glu Gln Ser Leu Lys Glu Thr Leu Val Glu Pro Gly Ser Phe Ser 
785                 790                 795                 800 


Gln Gln Asn Gly Glu His Pro Lys Pro Ala Leu Asp Thr Gly Tyr Glu 
                805                 810                 815     


Thr Glu Gln Asp Thr Ile Thr Ser Lys Val Pro Thr Asp Arg Glu Asp 
            820                 825                 830         


Ser Gln Arg Ile Asp Asp Leu Ser Ala Arg Asp Lys Pro Phe Asp Val 
        835                 840                 845             


Lys Cys Glu Leu Lys Phe Ala Asp Ser Asp Ala Asp Gly Asp 
    850                 855                 860         


<210>  11
<211>  6408
<212>  DNA
<213>  Homo sapiens

<400>  11
atgcctgctc tgggcccagc tcttctccag gctctctggg ccgggtgggt cctcaccctc       60

cagccccttc caccaactgc attcactccc aatggcacgt atctgcagca cctggcaagg      120

gaccccacct caggcaccct ctacctgggg gctaccaact tcctgttcca gctgagccct      180

gggctgcagc tggaggccac agtgtccacc ggccctgtgc tagacagcag ggactgcctg      240

ccacctgtga tgcctgatga gtgcccccag gcccagccta ccaacaaccc gaatcagctg      300

ctcctggtga gcccaggggc cctggtggta tgcgggagcg tgcaccaggg ggtctgtgaa      360

cagcggcgcc tggggcagct cgagcagctg ctgctgcggc cagagcggcc tggggacaca      420

caatatgtgg ctgccaatga tcctgcggtc agcacggtgg ggctggtagc ccagggcttg      480

gcaggggagc ccctcctgtt tgtggggcga ggatacacca gcaggggtgt ggggggtggc      540

attccaccca tcacaacccg ggccctgtgg ccgcccgacc cccaagctgc cttctcctat      600

gaggagacag ccaagctggc agtgggccgc ctctccgagt acagccacca cttcgtgagt      660

gcctttgcac gtggggccag cgcctacttc ctgttcctgc ggcgggacct gcaggctcag      720

tctagagctt ttcgtgccta tgtatctcga gtgtgtctcc gggaccagca ctactactcc      780

tatgtggagt tgcctctggc ctgcgaaggt ggccgctacg ggctgatcca ggctgcagct      840

gtggccacgt ccagggaggt ggcgcatggg gaggtgctct ttgcagcttt ctcctcggct      900

gcacccccca ctgtgggccg gcccccatcg gcggctgctg gggcatctgg agcctctgcc      960

ctctgtgcct tccccctgga tgaggtggac cggcttgcta atcgcacgcg agatgcctgc     1020

tacacccggg agggtcgtgc tgaggatggg accgaggtgg cctacatcga gtatgatgtc     1080

aattctgact gtgcacagct gccagtggac accctggatg cttatccctg tggctcagac     1140

cacacgccca gccccatggc cagccgggtc ccgctggaag ccacaccaat tctggagtgg     1200

ccagggattc agctaacagc tgtggcagtc accatggaag atggacacac catcgctttc     1260

ctgggtgata gtcaagggca gctgcacagg gtctacttgg gcccagggag cgatggccac     1320

ccatactcca cacagagcat ccagcagggg tctgcagtga gcagagacct cacctttgat     1380

gggacctttg agcacctgta tgtcatgacc cagagcacac ttctgaaggt tcctgtggct     1440

tcctgtgctc agcacctgga ctgtgcatct tgccttgctc acagggaccc atactgtggg     1500

tggtgcgtgc tccttggcag gtgcagtcgc cgttctgagt gctcgagggg ccagggccca     1560

gagcagtggc tatggagctt ccagcctgag ctgggctgtc tgcaagtggc agccatgagt     1620

cctgccaaca tcagccgaga ggagacgagg gaggttttcc tatcagtgcc agacctgcca     1680

cccctgtggc caggggagtc atattcctgc cactttgggg aacatcagag tcctgccctg     1740

ctgactggtt ctggtgtgat gtgcccctcc ccagacccta gtgaggcccc agtgctgccg     1800

agaggagccg actacgtatc cgtgagcgtg gagctcagat ttggcgctgt tgtgatcgcc     1860

aaaacttccc tctctttcta tgactgtgtg gcggtcactg aactccgccc atctgcgcag     1920

tgccaggcct gtgtgagcag ccgctggggg tgtaactggt gtgtctggca gcacctgtgc     1980

acccacaagg cctcgtgtga tgctgggccc atggttgcaa gccatcagag cccgcttgtc     2040

tccccagacc ctcctgcaag aggtggaccc agcccctccc cacccacagc ccccaaagcc     2100

ctggccaccc ctgctcctga cacccttccc gtggagcctg gggctccctc cacagccaca     2160

gcttcggaca tctcacctgg ggctagtcct tccctgctca gcccctgggg gccatgggca     2220

ggttctggct ccatatcttc ccctggctcc acagggtcgc ctctccatga ggagccctcc     2280

cctcccagcc cccaaaatgg acctggaacc gctgtccctg cccccactga cttcagaccc     2340

tcagccacac ctgaggacct cttggcctcc ccgctgtcac cgtcagaggt agcagcagtg     2400

ccccctgcag accctggccc cgaggctctt catcccacag tgcccctgga cctgccccct     2460

gccactgttc ctgccaccac tttcccaggg gccatgggct ccgtgaagcc cgccctggac     2520

tggctcacga gagaaggcgg cgagctgccc gaggcggacg agtggacggg gggtgacgca     2580

cccgccttct ccacttccac cctcctctca ggtgatggag actcagcaga gcttgagggc     2640

cctcccgccc ccctcatcct cccgtccagc ctcgactacc agtatgacac ccccgggctc     2700

tgggagctgg aagaggcgac cttgggggca agctcctgcc cctgtgtgga gagcgttcag     2760

ggctccacgt tgatgccggt ccatgtggag cgggaaatcc ggctgctagg caggaacctg     2820

caccttttcc aggatggccc aggagacaat gagtgtgtga tggagctgga gggcctcgag     2880

gtggtggttg aggcccgggt cgagtgtgag ccacctccag atacccagtg ccatgtcacc     2940

tgccagcagc accagctcag ctatgaggct ctgcagccgg agctccgtgt ggggctgttt     3000

ctgcgtcggg ccggccgtct gcgtgtggac agtgctgagg ggctgcatgt ggtactgtat     3060

gactgttccg tgggacatgg agactgcagc cgctgccaaa ctgccatgcc ccagtatggc     3120

tgtgtgtggt gtgaggggga gcgtccacgt tgtgtgaccc gggaggcctg tggtgaggct     3180

gaggctgtgg ccacccagtg cccagcgccc ctcatccact cggtggagcc actgactggg     3240

cctgtagacg gaggcacccg tgtcaccatc aggggctcca acctgggcca gcatgtgcag     3300

gatgtgctgg gcatggtcac ggtggctgga gtgccctgtg ctgtggatgc ccaggagtac     3360

gaggtctcca gcagcctcgt gtgcatcacc ggggccagtg gggaggaggt ggccggcgcc     3420

acagcggtgg aggtgccggg aagaggacgt ggtgtctcag aacacgactt tgcctaccag     3480

gatccgaagg tccattccat cttcccggcc cgcggcccca gagctggggg cacccgtctc     3540

accctgaatg gctccaagct cctgactggg cggctggagg acatccgagt ggtggttgga     3600

gaccagcctt gtcacttgct gccggagcag cagtcagaac aactgcggtg tgagaccagc     3660

ccacgcccca cgcctgccac gctccctgtg gctgtgtggt ttggggccac ggagcggagg     3720

cttcaacgcg gacagttcaa gtataccttg gaccccaaca tcacctctgc tggccccacc     3780

aagagcttcc tcagtggagg acgtgagata tgcgtccgtg gccagaatct ggacgtggta     3840

cagacgccaa gaatccgggt gaccgtggtc tcgagaatgc tgcagcccag ccaggggctt     3900

ggacggaggc gtcgcgtggt cccggagacg gcatgttccc ttggaccctc ctgcagtagc     3960

cagcaatttg aggagccgtg ccatgtcaac tcctcccagc tcatcacgtg ccgcacacct     4020

gccctcccag gcctgcctga ggacccctgg gtccgggtgg aatttatcct tgacaacctg     4080

gtctttgact ttgcaacact gaaccccaca cctttctcct atgaggccga ccccaccctg     4140

cagccactca accctgagga ccccaccatg ccattccggc acaagcctgg gagtgtgttc     4200

tccgtggagg gggagaacct ggaccttgca atgtccaagg aggaggtggt ggctatgata     4260

ggggatggcc cctgtgtggt gaagacgctg acgcggcacc acctgtactg cgagcccccc     4320

gtggagcagc ccctgccacg gcaccatgcc ctccgagagg cacctgactc tttgcctgag     4380

ttcacggtgc agatggggaa cttgcgcttc tccctgggtc acgtgcagta tgacggcgag     4440

agccctgggg cttttcctgt ggcagcccag gtgggcttgg gggtgggcac ctctcttctg     4500

gctctgggtg tcatcatcat tgtcctcatg tacaggagga agagcaagca ggccctgagg     4560

gactataaga aggttcagat ccagctggag aatctggaga gcagtgtgcg ggaccgctgc     4620

aagaaggaat tcacagacct catgactgag atgaccgatc tcaccagtga cctcctgggc     4680

agcggcatcc ccttcctcga ctacaaggtg tatgcggaga ggatcttctt ccctgggcac     4740

cgcgagtcgc ccttgcaccg ggacctgggt gtgcctgaga gcagacggcc cactgtggag     4800

caagggctgg ggcagctctc taacctgctc aacagcaagc tcttcctcac caagttcatc     4860

cacacgctgg agagccagcg caccttttca gctcgggacc gtgcctacgt ggcatctctg     4920

ctcaccgtgg cactgcatgg gaagcttgag tatttcactg acatcctccg cactctgctc     4980

agtgacctgg ttgcccagta tgtggccaag aaccccaagc tgatgctgcg caggacagag     5040

actgtggtgg agaagctgct caccaactgg atgtccatct gtctgtatac cttcgtgagg     5100

gactccgtag gggagcctct gtacatgctc tttcgaggga ttaagcacca agtggataag     5160

gggccagtgg acagtgtgac aggcaaggcc aaatacacct tgaacgacaa ccgcctgctc     5220

agagaggatg tggagtaccg tcccctgacc ttgaatgcac tattggctgt ggggcctggg     5280

gcaggagagg cccagggcgt gcccgtgaag gtcctagact gtgacaccat ctcccaggca     5340

aaggagaaga tgctggacca gctttataaa ggagtgcctc tcacccagcg gccagaccct     5400

cgcacccttg atgttgagtg gcggtctggg gtggccgggc acctcattct ttctgacgag     5460

gatgtcactt ctgaggtcca gggtctgtgg aggcgcctga acacactgca gcattacaag     5520

gtcccagatg gagcaactgt ggccctcgtc ccctgcctca ccaagcatgt gctccgggaa     5580

aaccaggatt atgtccctgg agagcggacc ccaatgctgg aggatgtaga tgaggggggc     5640

atccggccct ggcacctggt gaagccaagt gatgagccgg agccgcccag gcctcggagg     5700

ggcagccttc ggggcgggga gcgtgagcgc gccaaggcca tccctgagat ctacctgacc     5760

cgcctgctgt ccatgaaggg caccctgcag aagttcgtgg atgacctgtt ccaggtgatt     5820

ctcagcacca gccgccccgt gccgctcgct gtgaagtact tctttgacct gctggatgag     5880

caggcccagc agcatggcat ctccgaccag gacaccatcc acatctggaa gaccaacagc     5940

ttgcctctga ggttctggat caatataata aaaaacccgc agtttgtgtt cgacgtgcaa     6000

acatctgata acatggatgc ggtgctcctt gtcattgcac agaccttcat ggacgcctgc     6060

accctggccg accacaagct gggccgggac tccccgatca acaaacttct gtatgcacgg     6120

gacattcccc ggtacaagcg gatggtggaa aggtactatg cagacatcag acagactgtc     6180

ccagccagcg accaagagat gaactctgtc ctggctgaac tgtcctggaa ctactccgga     6240

gacctcgggg cgcgagtggc cctgcatgaa ctctacaagt acatcaacaa gtactatgac     6300

cagatcatca ctgccctgga ggaggatggc acggcccaga agatgcagct gggctatcgg     6360

ctccagcaga ttgcagctgc tgtggaaaac aaggtcacag atctatag                  6408


<210>  12
<211>  2135
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Ala Leu Gly Pro Ala Leu Leu Gln Ala Leu Trp Ala Gly Trp 
1               5                   10                  15      


Val Leu Thr Leu Gln Pro Leu Pro Pro Thr Ala Phe Thr Pro Asn Gly 
            20                  25                  30          


Thr Tyr Leu Gln His Leu Ala Arg Asp Pro Thr Ser Gly Thr Leu Tyr 
        35                  40                  45              


Leu Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  


Glu Ala Thr Val Ser Thr Gly Pro Val Leu Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  


Pro Pro Val Met Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      


Pro Asn Gln Leu Leu Leu Val Ser Pro Gly Ala Leu Val Val Cys Gly 
            100                 105                 110         


Ser Val His Gln Gly Val Cys Glu Gln Arg Arg Leu Gly Gln Leu Glu 
        115                 120                 125             


Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 


Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 


Ala Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     


Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Trp Pro Pro 
            180                 185                 190         


Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             


Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Ala Arg 
    210                 215                 220                 


Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Gln Ala Gln 
225                 230                 235                 240 


Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Arg Asp Gln 
                245                 250                 255     


His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Glu Gly Gly Arg 
            260                 265                 270         


Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Arg Glu Val Ala 
        275                 280                 285             


His Gly Glu Val Leu Phe Ala Ala Phe Ser Ser Ala Ala Pro Pro Thr 
    290                 295                 300                 


Val Gly Arg Pro Pro Ser Ala Ala Ala Gly Ala Ser Gly Ala Ser Ala 
305                 310                 315                 320 


Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Arg Leu Ala Asn Arg Thr 
                325                 330                 335     


Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asp Gly Thr Glu 
            340                 345                 350         


Val Ala Tyr Ile Glu Tyr Asp Val Asn Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             


Val Asp Thr Leu Asp Ala Tyr Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 


Pro Met Ala Ser Arg Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Trp 
385                 390                 395                 400 


Pro Gly Ile Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     


Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         


Leu Gly Pro Gly Ser Asp Gly His Pro Tyr Ser Thr Gln Ser Ile Gln 
        435                 440                 445             


Gln Gly Ser Ala Val Ser Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 


His Leu Tyr Val Met Thr Gln Ser Thr Leu Leu Lys Val Pro Val Ala 
465                 470                 475                 480 


Ser Cys Ala Gln His Leu Asp Cys Ala Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         


Glu Cys Ser Arg Gly Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             


Pro Glu Leu Gly Cys Leu Gln Val Ala Ala Met Ser Pro Ala Asn Ile 
    530                 535                 540                 


Ser Arg Glu Glu Thr Arg Glu Val Phe Leu Ser Val Pro Asp Leu Pro 
545                 550                 555                 560 


Pro Leu Trp Pro Gly Glu Ser Tyr Ser Cys His Phe Gly Glu His Gln 
                565                 570                 575     


Ser Pro Ala Leu Leu Thr Gly Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         


Pro Ser Glu Ala Pro Val Leu Pro Arg Gly Ala Asp Tyr Val Ser Val 
        595                 600                 605             


Ser Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Lys Thr Ser Leu 
    610                 615                 620                 


Ser Phe Tyr Asp Cys Val Ala Val Thr Glu Leu Arg Pro Ser Ala Gln 
625                 630                 635                 640 


Cys Gln Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     


Gln His Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         


Ala Ser His Gln Ser Pro Leu Val Ser Pro Asp Pro Pro Ala Arg Gly 
        675                 680                 685             


Gly Pro Ser Pro Ser Pro Pro Thr Ala Pro Lys Ala Leu Ala Thr Pro 
    690                 695                 700                 


Ala Pro Asp Thr Leu Pro Val Glu Pro Gly Ala Pro Ser Thr Ala Thr 
705                 710                 715                 720 


Ala Ser Asp Ile Ser Pro Gly Ala Ser Pro Ser Leu Leu Ser Pro Trp 
                725                 730                 735     


Gly Pro Trp Ala Gly Ser Gly Ser Ile Ser Ser Pro Gly Ser Thr Gly 
            740                 745                 750         


Ser Pro Leu His Glu Glu Pro Ser Pro Pro Ser Pro Gln Asn Gly Pro 
        755                 760                 765             


Gly Thr Ala Val Pro Ala Pro Thr Asp Phe Arg Pro Ser Ala Thr Pro 
    770                 775                 780                 


Glu Asp Leu Leu Ala Ser Pro Leu Ser Pro Ser Glu Val Ala Ala Val 
785                 790                 795                 800 


Pro Pro Ala Asp Pro Gly Pro Glu Ala Leu His Pro Thr Val Pro Leu 
                805                 810                 815     


Asp Leu Pro Pro Ala Thr Val Pro Ala Thr Thr Phe Pro Gly Ala Met 
            820                 825                 830         


Gly Ser Val Lys Pro Ala Leu Asp Trp Leu Thr Arg Glu Gly Gly Glu 
        835                 840                 845             


Leu Pro Glu Ala Asp Glu Trp Thr Gly Gly Asp Ala Pro Ala Phe Ser 
    850                 855                 860                 


Thr Ser Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu Leu Glu Gly 
865                 870                 875                 880 


Pro Pro Ala Pro Leu Ile Leu Pro Ser Ser Leu Asp Tyr Gln Tyr Asp 
                885                 890                 895     


Thr Pro Gly Leu Trp Glu Leu Glu Glu Ala Thr Leu Gly Ala Ser Ser 
            900                 905                 910         


Cys Pro Cys Val Glu Ser Val Gln Gly Ser Thr Leu Met Pro Val His 
        915                 920                 925             


Val Glu Arg Glu Ile Arg Leu Leu Gly Arg Asn Leu His Leu Phe Gln 
    930                 935                 940                 


Asp Gly Pro Gly Asp Asn Glu Cys Val Met Glu Leu Glu Gly Leu Glu 
945                 950                 955                 960 


Val Val Val Glu Ala Arg Val Glu Cys Glu Pro Pro Pro Asp Thr Gln 
                965                 970                 975     


Cys His Val Thr Cys Gln Gln His Gln Leu Ser Tyr Glu Ala Leu Gln 
            980                 985                 990         


Pro Glu Leu Arg Val Gly Leu Phe  Leu Arg Arg Ala Gly  Arg Leu Arg 
        995                 1000                 1005             


Val Asp  Ser Ala Glu Gly Leu  His Val Val Leu Tyr  Asp Cys Ser 
    1010                 1015                 1020             


Val Gly  His Gly Asp Cys Ser  Arg Cys Gln Thr Ala  Met Pro Gln 
    1025                 1030                 1035             


Tyr Gly  Cys Val Trp Cys Glu  Gly Glu Arg Pro Arg  Cys Val Thr 
    1040                 1045                 1050             


Arg Glu  Ala Cys Gly Glu Ala  Glu Ala Val Ala Thr  Gln Cys Pro 
    1055                 1060                 1065             


Ala Pro  Leu Ile His Ser Val  Glu Pro Leu Thr Gly  Pro Val Asp 
    1070                 1075                 1080             


Gly Gly  Thr Arg Val Thr Ile  Arg Gly Ser Asn Leu  Gly Gln His 
    1085                 1090                 1095             


Val Gln  Asp Val Leu Gly Met  Val Thr Val Ala Gly  Val Pro Cys 
    1100                 1105                 1110             


Ala Val  Asp Ala Gln Glu Tyr  Glu Val Ser Ser Ser  Leu Val Cys 
    1115                 1120                 1125             


Ile Thr  Gly Ala Ser Gly Glu  Glu Val Ala Gly Ala  Thr Ala Val 
    1130                 1135                 1140             


Glu Val  Pro Gly Arg Gly Arg  Gly Val Ser Glu His  Asp Phe Ala 
    1145                 1150                 1155             


Tyr Gln  Asp Pro Lys Val His  Ser Ile Phe Pro Ala  Arg Gly Pro 
    1160                 1165                 1170             


Arg Ala  Gly Gly Thr Arg Leu  Thr Leu Asn Gly Ser  Lys Leu Leu 
    1175                 1180                 1185             


Thr Gly  Arg Leu Glu Asp Ile  Arg Val Val Val Gly  Asp Gln Pro 
    1190                 1195                 1200             


Cys His  Leu Leu Pro Glu Gln  Gln Ser Glu Gln Leu  Arg Cys Glu 
    1205                 1210                 1215             


Thr Ser  Pro Arg Pro Thr Pro  Ala Thr Leu Pro Val  Ala Val Trp 
    1220                 1225                 1230             


Phe Gly  Ala Thr Glu Arg Arg  Leu Gln Arg Gly Gln  Phe Lys Tyr 
    1235                 1240                 1245             


Thr Leu  Asp Pro Asn Ile Thr  Ser Ala Gly Pro Thr  Lys Ser Phe 
    1250                 1255                 1260             


Leu Ser  Gly Gly Arg Glu Ile  Cys Val Arg Gly Gln  Asn Leu Asp 
    1265                 1270                 1275             


Val Val  Gln Thr Pro Arg Ile  Arg Val Thr Val Val  Ser Arg Met 
    1280                 1285                 1290             


Leu Gln  Pro Ser Gln Gly Leu  Gly Arg Arg Arg Arg  Val Val Pro 
    1295                 1300                 1305             


Glu Thr  Ala Cys Ser Leu Gly  Pro Ser Cys Ser Ser  Gln Gln Phe 
    1310                 1315                 1320             


Glu Glu  Pro Cys His Val Asn  Ser Ser Gln Leu Ile  Thr Cys Arg 
    1325                 1330                 1335             


Thr Pro  Ala Leu Pro Gly Leu  Pro Glu Asp Pro Trp  Val Arg Val 
    1340                 1345                 1350             


Glu Phe  Ile Leu Asp Asn Leu  Val Phe Asp Phe Ala  Thr Leu Asn 
    1355                 1360                 1365             


Pro Thr  Pro Phe Ser Tyr Glu  Ala Asp Pro Thr Leu  Gln Pro Leu 
    1370                 1375                 1380             


Asn Pro  Glu Asp Pro Thr Met  Pro Phe Arg His Lys  Pro Gly Ser 
    1385                 1390                 1395             


Val Phe  Ser Val Glu Gly Glu  Asn Leu Asp Leu Ala  Met Ser Lys 
    1400                 1405                 1410             


Glu Glu  Val Val Ala Met Ile  Gly Asp Gly Pro Cys  Val Val Lys 
    1415                 1420                 1425             


Thr Leu  Thr Arg His His Leu  Tyr Cys Glu Pro Pro  Val Glu Gln 
    1430                 1435                 1440             


Pro Leu  Pro Arg His His Ala  Leu Arg Glu Ala Pro  Asp Ser Leu 
    1445                 1450                 1455             


Pro Glu  Phe Thr Val Gln Met  Gly Asn Leu Arg Phe  Ser Leu Gly 
    1460                 1465                 1470             


His Val  Gln Tyr Asp Gly Glu  Ser Pro Gly Ala Phe  Pro Val Ala 
    1475                 1480                 1485             


Ala Gln  Val Gly Leu Gly Val  Gly Thr Ser Leu Leu  Ala Leu Gly 
    1490                 1495                 1500             


Val Ile  Ile Ile Val Leu Met  Tyr Arg Arg Lys Ser  Lys Gln Ala 
    1505                 1510                 1515             


Leu Arg  Asp Tyr Lys Lys Val  Gln Ile Gln Leu Glu  Asn Leu Glu 
    1520                 1525                 1530             


Ser Ser  Val Arg Asp Arg Cys  Lys Lys Glu Phe Thr  Asp Leu Met 
    1535                 1540                 1545             


Thr Glu  Met Thr Asp Leu Thr  Ser Asp Leu Leu Gly  Ser Gly Ile 
    1550                 1555                 1560             


Pro Phe  Leu Asp Tyr Lys Val  Tyr Ala Glu Arg Ile  Phe Phe Pro 
    1565                 1570                 1575             


Gly His  Arg Glu Ser Pro Leu  His Arg Asp Leu Gly  Val Pro Glu 
    1580                 1585                 1590             


Ser Arg  Arg Pro Thr Val Glu  Gln Gly Leu Gly Gln  Leu Ser Asn 
    1595                 1600                 1605             


Leu Leu  Asn Ser Lys Leu Phe  Leu Thr Lys Phe Ile  His Thr Leu 
    1610                 1615                 1620             


Glu Ser  Gln Arg Thr Phe Ser  Ala Arg Asp Arg Ala  Tyr Val Ala 
    1625                 1630                 1635             


Ser Leu  Leu Thr Val Ala Leu  His Gly Lys Leu Glu  Tyr Phe Thr 
    1640                 1645                 1650             


Asp Ile  Leu Arg Thr Leu Leu  Ser Asp Leu Val Ala  Gln Tyr Val 
    1655                 1660                 1665             


Ala Lys  Asn Pro Lys Leu Met  Leu Arg Arg Thr Glu  Thr Val Val 
    1670                 1675                 1680             


Glu Lys  Leu Leu Thr Asn Trp  Met Ser Ile Cys Leu  Tyr Thr Phe 
    1685                 1690                 1695             


Val Arg  Asp Ser Val Gly Glu  Pro Leu Tyr Met Leu  Phe Arg Gly 
    1700                 1705                 1710             


Ile Lys  His Gln Val Asp Lys  Gly Pro Val Asp Ser  Val Thr Gly 
    1715                 1720                 1725             


Lys Ala  Lys Tyr Thr Leu Asn  Asp Asn Arg Leu Leu  Arg Glu Asp 
    1730                 1735                 1740             


Val Glu  Tyr Arg Pro Leu Thr  Leu Asn Ala Leu Leu  Ala Val Gly 
    1745                 1750                 1755             


Pro Gly  Ala Gly Glu Ala Gln  Gly Val Pro Val Lys  Val Leu Asp 
    1760                 1765                 1770             


Cys Asp  Thr Ile Ser Gln Ala  Lys Glu Lys Met Leu  Asp Gln Leu 
    1775                 1780                 1785             


Tyr Lys  Gly Val Pro Leu Thr  Gln Arg Pro Asp Pro  Arg Thr Leu 
    1790                 1795                 1800             


Asp Val  Glu Trp Arg Ser Gly  Val Ala Gly His Leu  Ile Leu Ser 
    1805                 1810                 1815             


Asp Glu  Asp Val Thr Ser Glu  Val Gln Gly Leu Trp  Arg Arg Leu 
    1820                 1825                 1830             


Asn Thr  Leu Gln His Tyr Lys  Val Pro Asp Gly Ala  Thr Val Ala 
    1835                 1840                 1845             


Leu Val  Pro Cys Leu Thr Lys  His Val Leu Arg Glu  Asn Gln Asp 
    1850                 1855                 1860             


Tyr Val  Pro Gly Glu Arg Thr  Pro Met Leu Glu Asp  Val Asp Glu 
    1865                 1870                 1875             


Gly Gly  Ile Arg Pro Trp His  Leu Val Lys Pro Ser  Asp Glu Pro 
    1880                 1885                 1890             


Glu Pro  Pro Arg Pro Arg Arg  Gly Ser Leu Arg Gly  Gly Glu Arg 
    1895                 1900                 1905             


Glu Arg  Ala Lys Ala Ile Pro  Glu Ile Tyr Leu Thr  Arg Leu Leu 
    1910                 1915                 1920             


Ser Met  Lys Gly Thr Leu Gln  Lys Phe Val Asp Asp  Leu Phe Gln 
    1925                 1930                 1935             


Val Ile  Leu Ser Thr Ser Arg  Pro Val Pro Leu Ala  Val Lys Tyr 
    1940                 1945                 1950             


Phe Phe  Asp Leu Leu Asp Glu  Gln Ala Gln Gln His  Gly Ile Ser 
    1955                 1960                 1965             


Asp Gln  Asp Thr Ile His Ile  Trp Lys Thr Asn Ser  Leu Pro Leu 
    1970                 1975                 1980             


Arg Phe  Trp Ile Asn Ile Ile  Lys Asn Pro Gln Phe  Val Phe Asp 
    1985                 1990                 1995             


Val Gln  Thr Ser Asp Asn Met  Asp Ala Val Leu Leu  Val Ile Ala 
    2000                 2005                 2010             


Gln Thr  Phe Met Asp Ala Cys  Thr Leu Ala Asp His  Lys Leu Gly 
    2015                 2020                 2025             


Arg Asp  Ser Pro Ile Asn Lys  Leu Leu Tyr Ala Arg  Asp Ile Pro 
    2030                 2035                 2040             


Arg Tyr  Lys Arg Met Val Glu  Arg Tyr Tyr Ala Asp  Ile Arg Gln 
    2045                 2050                 2055             


Thr Val  Pro Ala Ser Asp Gln  Glu Met Asn Ser Val  Leu Ala Glu 
    2060                 2065                 2070             


Leu Ser  Trp Asn Tyr Ser Gly  Asp Leu Gly Ala Arg  Val Ala Leu 
    2075                 2080                 2085             


His Glu  Leu Tyr Lys Tyr Ile  Asn Lys Tyr Tyr Asp  Gln Ile Ile 
    2090                 2095                 2100             


Thr Ala  Leu Glu Glu Asp Gly  Thr Ala Gln Lys Met  Gln Leu Gly 
    2105                 2110                 2115             


Tyr Arg  Leu Gln Gln Ile Ala  Ala Ala Val Glu Asn  Lys Val Thr 
    2120                 2125                 2130             


Asp Leu  
    2135 


<210>  13
<211>  6360
<212>  DNA
<213>  Mus musculus

<400>  13
atgtctgtcc tcggcccagt tcttctccag gtgttctggg ccgggtgtgt cgtcaccctg       60

cggtcccctc tgccagctgc tttcactgcc aatggcacac atctacaaca cttggcaagg      120

gaccccacca caggtaccct ctatgtaggg gccaccaact tcctgttcca gttgagccct      180

gggctgcagc tggaagccgt ggtgtccacg ggccctgtga atgacagccg ggattgcctg      240

ccacctgtga tacctgatga atgtccccaa gcccagccta ctaacaaccc taaccagctg      300

ctcctggtga gcccagaggc tctggtggtg tgtgggagcg tacaccaggg catctgtgag      360

ctacggagcc tgggacagat caggcagctg ctgctacggc cagagcgacc tggggacacc      420

cagtatgtgg ctgcaaatga ccctgcagtc agtacagtgg ggctggtggc ccagggattg      480

gtaggggagc ccctcctgtt tgtggggcgg gggtacacca gcaggggtgt aggtggtggg      540

attcctccca ttacaacccg agccctgcga ccaccggacc cccaagctgc cttctcttat      600

gaagaaacag ccaagttagc agtgggccgc ctgtccgagt acagccacca cttcgtgagt      660

gcctttgtac gcggggccag tgcatacttc ctgttcttgc ggcgagacct gaaggcccct      720

tctagagctt tccgtgccta tgtgtctcga gtgtgccttc aggaccagca ctactactct      780

tatgtggaat tgcccctggc ctgccagggt ggtcgttacg gtcttatcca ggctgcagct      840

gtagccacgt ccaaggaggt ggcccgtggg gacgtactct ttgcagcttt ctcctcagtg      900

gctcctccca ctgtggattg gcccctgtca gcatctactg gggcatctgg aacctctgtg      960

ctctgtgcct tccccctgga tgaggtagac cagcttgcta attacactcg agatgcctgt     1020

tatactcggg aaggccgtgc tgagaacggg accaaggttg ctgacattgc atacgatgtc     1080

ctttccgact gtgcgcagct accagtggac accccggatg cttttccatg tggctctgac     1140

cacacaccca gtcccatggt cagctgtgtc cctttggaag ccacgccaat tctggagcta     1200

ccaggggttc agctaacagc tgtggctgtc accatggagg atggacacac tattgctttc     1260

ctgggtgaca gtcaaggaca gttgcatagg gtctacttag gccctggaag aagtgctgcc     1320

ccatattcta aacagagcat ccagccgggg tctcctgtga acagagatct tacctttgat     1380

ggtacctttg agcatctcta tgtagcaact cagactactc ttgtgaaggt tcctgtggct     1440

ccttgtgctc agcatctgga ctgtgactct tgccttgctc acagggaccc ttattgcgga     1500

tggtgtgtgc tcctgggcag gtgtagtcgc cggtcggagt gctcaaggga ccagggccca     1560

gagcagtggc tgtggagctt ccagccggaa ctgggctgtc ttcgagtggt ggccgtgagc     1620

cctgccaata tcagtcggga agagaggagg gaggttttct tgtcagtgcc aggcctgcca     1680

tctctctggc caggggagtc atatttctgc tactttggag accaacagag tcctgctcta     1740

ctgaccagtt ctggtgtgat gtgtccctcc ccagacccca gtgaggctcc agtgctgcag     1800

agaggagccg accatatctc tgtgaacgtg gagctcaggt ttggtgccgt ggtgatcgcc     1860

agcacctccc tctccttcta tgactgcgtg gcagttactg cgtcttcccc atctgcaccg     1920

tgccgggcct gtgtgagcag ccgctggggc tgtaactggt gtgtgtggca gcagctgtgc     1980

acacacaagg cctcgtgtga cgctgggcct atggtggcaa gccaacagag cccactcctt     2040

cccctaatcc ctcctgcaag ggatgaactc acccctttcc cacccacagt cccccaaacc     2100

acggtcactc ctacccccaa cagcttccca atagagccta gggctccctc cacagcctca     2160

gatgtcctac ctggggccaa gccttcccgg ctcagcctct ggggcccatg ggcaggtcct     2220

ggccccatac tttcccctac ttccacagag tcacctcttc atgagaagcc ccttcctcct     2280

gaccccccta ccatacctgg aaccactgtc cctgccccca ctggcttggg accatcgacc     2340

acacctgagg acctcttggc ctcctaccca ttcccctcag atgcagctgc agtgtcccct     2400

gcagagcctg gccctgaggc tctgccttcc atggtggctc tggaccagcc ccctggcact     2460

gttccagaca ctactttccc aggggcccct ggctccatga agcccgttct ggattggctc     2520

accaaaggag gcggcgagct gcccgaggcg gatgagtgga tggggggtga cacgcccgcc     2580

ttctccactt ccacactcct ctcaggtgat ggagactcag cagagcacga gggccctcct     2640

gcccccctca tcctcctgtc cagcctcgac taccagtacg acacccccgg gctctgggag     2700

ctgggagagg tgaatcagag ggtgagctcc tgcccctgtg tggagaccgt ccagggctcc     2760

ttgctgatac cggtccatgt ggaacgcgaa gtccagcttc gaggcaggaa cctgtggctt     2820

ttccaggatg gcccgaggag cagcgagtgt gtgctggagc tagggagtcg ggaggtggct     2880

gtggaggctc aggtggagtg tgcgccgcct ccagatgtct ggtgccacat caagtgccag     2940

cagcatcagt tcagctatga agctttgaag ccagaactgc aggtggggct gttcctgcgt     3000

tgggcaggcg gtctgcgcgt ggacagtgcc gatgggctgc atgtggtgtt gtatgactgc     3060

tctgtgggac atggggactg cagccgctgc caaactgcca tgcctcagta cgactgtgtg     3120

tggtgtgagg gggagcgtcc gcgttgtgtg gcccgggaag cctgtaatga agccgagact     3180

gtggccactc agtgccccgc acctctcatt cactcggtgg atccactgac tggacctata     3240

gatggaggca cccgtgtcac tatcaggggc tccaacctgg gccaacatgt gcaggatgtc     3300

ctggacatgg tcagagtggc cggagttccc tgcgctgtgg atgctgggga gtatgatgtc     3360

tctagtagtc ttgtgtgcat cactggagcc agcggggagg aggtgactgg cactgtggca     3420

gtggaggtgc ctggaagagg acacggtgtc tcagagttca gctttgccta tcaggatcca     3480

aaagtacact ccatcttccc agcccgtggc cctagagctg gaggtacccg ccttaccctg     3540

catggttcta agctcctgac tggacggcta gaggacatcc gtgtggtggt tggagaccag     3600

ccttgccacc tgctcctgga gcagcagtct gagcagctac actgtgagac cggcccatac     3660

cctgtgcctg ctgaacttcc agtgactgtc ttgtttgggg ccactgagcg gaggcttcag     3720

cacggccaat tcaagtatac atcagacccc aatgtcacct cagtgggccc ctccaagagc     3780

ttcttcagcg gaggacgtga gatatgggtc cgcggccagg atcttgatgt ggtacagagg     3840

ccaagaatcc gagtgaccgt ggtcccaaga cagcatggcc aggggcttgc acagaagcaa     3900

cacgtggtcc ctgagaaatt tgaggagccg tgtctcgtga actcctccca cctcctcatg     3960

tgccgcactc ccgctctccc tggcccaccc tgggactctg gggtccaggt ggagtttatc     4020

ctcgacaaca tggtctttga ctttgctgca ctgagcccca cacccttctc ctatgaggct     4080

gatcccaccc tgcgttccct gaaccccgag gatcccagca cgccgttccg gcacaagcca     4140

gggagtgtgt tctctgtgga gggggagaat ctggacctcg ccatgtctaa agaagaggtg     4200

gtggccatga taggggacgg gccctgcgtg gtaaagacac tgacccggaa ccacctgtac     4260

tgtgagcccc ctgtggagca gcccctgcca catccccatg ccctccgaga ggctccagat     4320

gctttgcctg agttcacggt acagatgggc aacctgcgct tctccttggg tcatgtgcag     4380

tacgatggcg agagccccgt ggcttttcct gtggcagccc aagtgggctt gggagtgggc     4440

acgtctctcc tggctctggg tgtcatcatc attgtcctca tatacaggag gaagagcaag     4500

caggccctga gggactataa gaaagtgcag atccagctgg agaacctgga gagcagtgta     4560

cgggaccgct gtaagaagga gtttacagac ctcatgacgg agatgacgga tctcaccagt     4620

gacctccttg gcagcggtat ccccttcctt gactacaaag tgtatgctga gagggtcttc     4680

ttccctgggt accgggagtc ccccttgcac agggacctcg gtgtgcctga cagcaggcga     4740

cccaccgtgg aacagggcct ggggcagctc tccaacctgc taaacagcaa gctcttcctt     4800

accaagttca tccacacact ggagagtcag cgcaccttct ctgctcggga ccgtgcctac     4860

gtggcatctc tgctcactgt tgcacttcac gggaagcttg aatacttcac ggacatactg     4920

cggactctgc tcagtgacct ggtagctcag tatgttgcca agaaccccaa gctgatgctg     4980

cgcaggacag agaccgtggt agaaaagctg ctcaccaact ggatgtccat ctgcctctac     5040

acctttgtga gggactctgt gggagagcct ctgtatatgc tcttcagagg gattaagcat     5100

caagtggaca agggtcccgt ggacagtgtg actggcaaag ccaaatacac tctgaatgac     5160

aaccgcctgc tcagagagga tgtggagtac cgtcccttga ccttgaatgc tcttctggct     5220

gtggggcctg gggcaggaga agcccagtgt gtacctgtga aagtcctgga ctgtgacacc     5280

atctcccagg ccaaggagaa gatgctagac cagctttaca agggagtgcc tcttgcccag     5340

cggcccgact cttgcacctt ggatgttgaa tggcggtctg gagtggctgg gcaccttatc     5400

ctttctgatg aggacgtcac ttccgaactc cagggtctgt ggaggcgtct gaatacactg     5460

caacattaca aggtcccaga tggagcaacg gtggcccttg tcccctgcct caccaagcat     5520

attcttaggg aaaaccagga ttatgtccct ggggaacgga ccccaatgct ggaggatgta     5580

gatgaggggg gcatccggcc ctggcacctg gtaaagccga gtgatgaacc agagcctccc     5640

aggccgagga ggggcagcct tcggggtggg gagcgtgagc gagccaaggc tatccctgag     5700

atctacctga cacgcctgct atccatgaag ggcacactgc agaagtttgt ggatgacctg     5760

ttccaggtga ttctcagcac cagccgccct gtgcctctgg ctgtgaagta cttctttgac     5820

ttgctggatg aacaagctca gcagcatggc atctctgatc aggatactat ccacatctgg     5880

aagaccaaca gcctgccgct aaggttctgg atcaacatca tcaagaaccc acagtttgtg     5940

ttcgatgtgc agacttcgga taacatggat gctgtgctcc tggtcattgc acagaccttc     6000

atggatgctt gcaccctggc cgaccacaag ctgggccggg attctcccat caacaaactt     6060

ctgtatgctc gagatattcc ccgttacaaa cagatggtgg aaaggtacta tgcagacatc     6120

agacagactg tcccggccag tgaccaagag atgaactcag tcttggcgga gctgtcccgg     6180

aactgctctg ccgaccttgg ggcgcgagtg gctctgcatg aactctacaa gtatatcaac     6240

aagtactatg accagatcat cactgccctg gaggaggatg gcactgccca gaagatgcag     6300

ctgggctacc ggctccagca gatcgccgct gctgtggaaa acaaggtcac ggatctataa     6360


<210>  14
<211>  2119
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ser Val Leu Gly Pro Val Leu Leu Gln Val Phe Trp Ala Gly Cys 
1               5                   10                  15      


Val Val Thr Leu Arg Ser Pro Leu Pro Ala Ala Phe Thr Ala Asn Gly 
            20                  25                  30          


Thr His Leu Gln His Leu Ala Arg Asp Pro Thr Thr Gly Thr Leu Tyr 
        35                  40                  45              


Val Gly Ala Thr Asn Phe Leu Phe Gln Leu Ser Pro Gly Leu Gln Leu 
    50                  55                  60                  


Glu Ala Val Val Ser Thr Gly Pro Val Asn Asp Ser Arg Asp Cys Leu 
65                  70                  75                  80  


Pro Pro Val Ile Pro Asp Glu Cys Pro Gln Ala Gln Pro Thr Asn Asn 
                85                  90                  95      


Pro Asn Gln Leu Leu Leu Val Ser Pro Glu Ala Leu Val Val Cys Gly 
            100                 105                 110         


Ser Val His Gln Gly Ile Cys Glu Leu Arg Ser Leu Gly Gln Ile Arg 
        115                 120                 125             


Gln Leu Leu Leu Arg Pro Glu Arg Pro Gly Asp Thr Gln Tyr Val Ala 
    130                 135                 140                 


Ala Asn Asp Pro Ala Val Ser Thr Val Gly Leu Val Ala Gln Gly Leu 
145                 150                 155                 160 


Val Gly Glu Pro Leu Leu Phe Val Gly Arg Gly Tyr Thr Ser Arg Gly 
                165                 170                 175     


Val Gly Gly Gly Ile Pro Pro Ile Thr Thr Arg Ala Leu Arg Pro Pro 
            180                 185                 190         


Asp Pro Gln Ala Ala Phe Ser Tyr Glu Glu Thr Ala Lys Leu Ala Val 
        195                 200                 205             


Gly Arg Leu Ser Glu Tyr Ser His His Phe Val Ser Ala Phe Val Arg 
    210                 215                 220                 


Gly Ala Ser Ala Tyr Phe Leu Phe Leu Arg Arg Asp Leu Lys Ala Pro 
225                 230                 235                 240 


Ser Arg Ala Phe Arg Ala Tyr Val Ser Arg Val Cys Leu Gln Asp Gln 
                245                 250                 255     


His Tyr Tyr Ser Tyr Val Glu Leu Pro Leu Ala Cys Gln Gly Gly Arg 
            260                 265                 270         


Tyr Gly Leu Ile Gln Ala Ala Ala Val Ala Thr Ser Lys Glu Val Ala 
        275                 280                 285             


Arg Gly Asp Val Leu Phe Ala Ala Phe Ser Ser Val Ala Pro Pro Thr 
    290                 295                 300                 


Val Asp Trp Pro Leu Ser Ala Ser Thr Gly Ala Ser Gly Thr Ser Val 
305                 310                 315                 320 


Leu Cys Ala Phe Pro Leu Asp Glu Val Asp Gln Leu Ala Asn Tyr Thr 
                325                 330                 335     


Arg Asp Ala Cys Tyr Thr Arg Glu Gly Arg Ala Glu Asn Gly Thr Lys 
            340                 345                 350         


Val Ala Asp Ile Ala Tyr Asp Val Leu Ser Asp Cys Ala Gln Leu Pro 
        355                 360                 365             


Val Asp Thr Pro Asp Ala Phe Pro Cys Gly Ser Asp His Thr Pro Ser 
    370                 375                 380                 


Pro Met Val Ser Cys Val Pro Leu Glu Ala Thr Pro Ile Leu Glu Leu 
385                 390                 395                 400 


Pro Gly Val Gln Leu Thr Ala Val Ala Val Thr Met Glu Asp Gly His 
                405                 410                 415     


Thr Ile Ala Phe Leu Gly Asp Ser Gln Gly Gln Leu His Arg Val Tyr 
            420                 425                 430         


Leu Gly Pro Gly Arg Ser Ala Ala Pro Tyr Ser Lys Gln Ser Ile Gln 
        435                 440                 445             


Pro Gly Ser Pro Val Asn Arg Asp Leu Thr Phe Asp Gly Thr Phe Glu 
    450                 455                 460                 


His Leu Tyr Val Ala Thr Gln Thr Thr Leu Val Lys Val Pro Val Ala 
465                 470                 475                 480 


Pro Cys Ala Gln His Leu Asp Cys Asp Ser Cys Leu Ala His Arg Asp 
                485                 490                 495     


Pro Tyr Cys Gly Trp Cys Val Leu Leu Gly Arg Cys Ser Arg Arg Ser 
            500                 505                 510         


Glu Cys Ser Arg Asp Gln Gly Pro Glu Gln Trp Leu Trp Ser Phe Gln 
        515                 520                 525             


Pro Glu Leu Gly Cys Leu Arg Val Val Ala Val Ser Pro Ala Asn Ile 
    530                 535                 540                 


Ser Arg Glu Glu Arg Arg Glu Val Phe Leu Ser Val Pro Gly Leu Pro 
545                 550                 555                 560 


Ser Leu Trp Pro Gly Glu Ser Tyr Phe Cys Tyr Phe Gly Asp Gln Gln 
                565                 570                 575     


Ser Pro Ala Leu Leu Thr Ser Ser Gly Val Met Cys Pro Ser Pro Asp 
            580                 585                 590         


Pro Ser Glu Ala Pro Val Leu Gln Arg Gly Ala Asp His Ile Ser Val 
        595                 600                 605             


Asn Val Glu Leu Arg Phe Gly Ala Val Val Ile Ala Ser Thr Ser Leu 
    610                 615                 620                 


Ser Phe Tyr Asp Cys Val Ala Val Thr Ala Ser Ser Pro Ser Ala Pro 
625                 630                 635                 640 


Cys Arg Ala Cys Val Ser Ser Arg Trp Gly Cys Asn Trp Cys Val Trp 
                645                 650                 655     


Gln Gln Leu Cys Thr His Lys Ala Ser Cys Asp Ala Gly Pro Met Val 
            660                 665                 670         


Ala Ser Gln Gln Ser Pro Leu Leu Pro Leu Ile Pro Pro Ala Arg Asp 
        675                 680                 685             


Glu Leu Thr Pro Phe Pro Pro Thr Val Pro Gln Thr Thr Val Thr Pro 
    690                 695                 700                 


Thr Pro Asn Ser Phe Pro Ile Glu Pro Arg Ala Pro Ser Thr Ala Ser 
705                 710                 715                 720 


Asp Val Leu Pro Gly Ala Lys Pro Ser Arg Leu Ser Leu Trp Gly Pro 
                725                 730                 735     


Trp Ala Gly Pro Gly Pro Ile Leu Ser Pro Thr Ser Thr Glu Ser Pro 
            740                 745                 750         


Leu His Glu Lys Pro Leu Pro Pro Asp Pro Pro Thr Ile Pro Gly Thr 
        755                 760                 765             


Thr Val Pro Ala Pro Thr Gly Leu Gly Pro Ser Thr Thr Pro Glu Asp 
    770                 775                 780                 


Leu Leu Ala Ser Tyr Pro Phe Pro Ser Asp Ala Ala Ala Val Ser Pro 
785                 790                 795                 800 


Ala Glu Pro Gly Pro Glu Ala Leu Pro Ser Met Val Ala Leu Asp Gln 
                805                 810                 815     


Pro Pro Gly Thr Val Pro Asp Thr Thr Phe Pro Gly Ala Pro Gly Ser 
            820                 825                 830         


Met Lys Pro Val Leu Asp Trp Leu Thr Lys Gly Gly Gly Glu Leu Pro 
        835                 840                 845             


Glu Ala Asp Glu Trp Met Gly Gly Asp Thr Pro Ala Phe Ser Thr Ser 
    850                 855                 860                 


Thr Leu Leu Ser Gly Asp Gly Asp Ser Ala Glu His Glu Gly Pro Pro 
865                 870                 875                 880 


Ala Pro Leu Ile Leu Leu Ser Ser Leu Asp Tyr Gln Tyr Asp Thr Pro 
                885                 890                 895     


Gly Leu Trp Glu Leu Gly Glu Val Asn Gln Arg Val Ser Ser Cys Pro 
            900                 905                 910         


Cys Val Glu Thr Val Gln Gly Ser Leu Leu Ile Pro Val His Val Glu 
        915                 920                 925             


Arg Glu Val Gln Leu Arg Gly Arg Asn Leu Trp Leu Phe Gln Asp Gly 
    930                 935                 940                 


Pro Arg Ser Ser Glu Cys Val Leu Glu Leu Gly Ser Arg Glu Val Ala 
945                 950                 955                 960 


Val Glu Ala Gln Val Glu Cys Ala Pro Pro Pro Asp Val Trp Cys His 
                965                 970                 975     


Ile Lys Cys Gln Gln His Gln Phe Ser Tyr Glu Ala Leu Lys Pro Glu 
            980                 985                 990         


Leu Gln Val Gly Leu Phe Leu Arg  Trp Ala Gly Gly Leu  Arg Val Asp 
        995                 1000                 1005             


Ser Ala  Asp Gly Leu His Val  Val Leu Tyr Asp Cys  Ser Val Gly 
    1010                 1015                 1020             


His Gly  Asp Cys Ser Arg Cys  Gln Thr Ala Met Pro  Gln Tyr Asp 
    1025                 1030                 1035             


Cys Val  Trp Cys Glu Gly Glu  Arg Pro Arg Cys Val  Ala Arg Glu 
    1040                 1045                 1050             


Ala Cys  Asn Glu Ala Glu Thr  Val Ala Thr Gln Cys  Pro Ala Pro 
    1055                 1060                 1065             


Leu Ile  His Ser Val Asp Pro  Leu Thr Gly Pro Ile  Asp Gly Gly 
    1070                 1075                 1080             


Thr Arg  Val Thr Ile Arg Gly  Ser Asn Leu Gly Gln  His Val Gln 
    1085                 1090                 1095             


Asp Val  Leu Asp Met Val Arg  Val Ala Gly Val Pro  Cys Ala Val 
    1100                 1105                 1110             


Asp Ala  Gly Glu Tyr Asp Val  Ser Ser Ser Leu Val  Cys Ile Thr 
    1115                 1120                 1125             


Gly Ala  Ser Gly Glu Glu Val  Thr Gly Thr Val Ala  Val Glu Val 
    1130                 1135                 1140             


Pro Gly  Arg Gly His Gly Val  Ser Glu Phe Ser Phe  Ala Tyr Gln 
    1145                 1150                 1155             


Asp Pro  Lys Val His Ser Ile  Phe Pro Ala Arg Gly  Pro Arg Ala 
    1160                 1165                 1170             


Gly Gly  Thr Arg Leu Thr Leu  His Gly Ser Lys Leu  Leu Thr Gly 
    1175                 1180                 1185             


Arg Leu  Glu Asp Ile Arg Val  Val Val Gly Asp Gln  Pro Cys His 
    1190                 1195                 1200             


Leu Leu  Leu Glu Gln Gln Ser  Glu Gln Leu His Cys  Glu Thr Gly 
    1205                 1210                 1215             


Pro Tyr  Pro Val Pro Ala Glu  Leu Pro Val Thr Val  Leu Phe Gly 
    1220                 1225                 1230             


Ala Thr  Glu Arg Arg Leu Gln  His Gly Gln Phe Lys  Tyr Thr Ser 
    1235                 1240                 1245             


Asp Pro  Asn Val Thr Ser Val  Gly Pro Ser Lys Ser  Phe Phe Ser 
    1250                 1255                 1260             


Gly Gly  Arg Glu Ile Trp Val  Arg Gly Gln Asp Leu  Asp Val Val 
    1265                 1270                 1275             


Gln Arg  Pro Arg Ile Arg Val  Thr Val Val Pro Arg  Gln His Gly 
    1280                 1285                 1290             


Gln Gly  Leu Ala Gln Lys Gln  His Val Val Pro Glu  Lys Phe Glu 
    1295                 1300                 1305             


Glu Pro  Cys Leu Val Asn Ser  Ser His Leu Leu Met  Cys Arg Thr 
    1310                 1315                 1320             


Pro Ala  Leu Pro Gly Pro Pro  Trp Asp Ser Gly Val  Gln Val Glu 
    1325                 1330                 1335             


Phe Ile  Leu Asp Asn Met Val  Phe Asp Phe Ala Ala  Leu Ser Pro 
    1340                 1345                 1350             


Thr Pro  Phe Ser Tyr Glu Ala  Asp Pro Thr Leu Arg  Ser Leu Asn 
    1355                 1360                 1365             


Pro Glu  Asp Pro Ser Thr Pro  Phe Arg His Lys Pro  Gly Ser Val 
    1370                 1375                 1380             


Phe Ser  Val Glu Gly Glu Asn  Leu Asp Leu Ala Met  Ser Lys Glu 
    1385                 1390                 1395             


Glu Val  Val Ala Met Ile Gly  Asp Gly Pro Cys Val  Val Lys Thr 
    1400                 1405                 1410             


Leu Thr  Arg Asn His Leu Tyr  Cys Glu Pro Pro Val  Glu Gln Pro 
    1415                 1420                 1425             


Leu Pro  His Pro His Ala Leu  Arg Glu Ala Pro Asp  Ala Leu Pro 
    1430                 1435                 1440             


Glu Phe  Thr Val Gln Met Gly  Asn Leu Arg Phe Ser  Leu Gly His 
    1445                 1450                 1455             


Val Gln  Tyr Asp Gly Glu Ser  Pro Val Ala Phe Pro  Val Ala Ala 
    1460                 1465                 1470             


Gln Val  Gly Leu Gly Val Gly  Thr Ser Leu Leu Ala  Leu Gly Val 
    1475                 1480                 1485             


Ile Ile  Ile Val Leu Ile Tyr  Arg Arg Lys Ser Lys  Gln Ala Leu 
    1490                 1495                 1500             


Arg Asp  Tyr Lys Lys Val Gln  Ile Gln Leu Glu Asn  Leu Glu Ser 
    1505                 1510                 1515             


Ser Val  Arg Asp Arg Cys Lys  Lys Glu Phe Thr Asp  Leu Met Thr 
    1520                 1525                 1530             


Glu Met  Thr Asp Leu Thr Ser  Asp Leu Leu Gly Ser  Gly Ile Pro 
    1535                 1540                 1545             


Phe Leu  Asp Tyr Lys Val Tyr  Ala Glu Arg Val Phe  Phe Pro Gly 
    1550                 1555                 1560             


Tyr Arg  Glu Ser Pro Leu His  Arg Asp Leu Gly Val  Pro Asp Ser 
    1565                 1570                 1575             


Arg Arg  Pro Thr Val Glu Gln  Gly Leu Gly Gln Leu  Ser Asn Leu 
    1580                 1585                 1590             


Leu Asn  Ser Lys Leu Phe Leu  Thr Lys Phe Ile His  Thr Leu Glu 
    1595                 1600                 1605             


Ser Gln  Arg Thr Phe Ser Ala  Arg Asp Arg Ala Tyr  Val Ala Ser 
    1610                 1615                 1620             


Leu Leu  Thr Val Ala Leu His  Gly Lys Leu Glu Tyr  Phe Thr Asp 
    1625                 1630                 1635             


Ile Leu  Arg Thr Leu Leu Ser  Asp Leu Val Ala Gln  Tyr Val Ala 
    1640                 1645                 1650             


Lys Asn  Pro Lys Leu Met Leu  Arg Arg Thr Glu Thr  Val Val Glu 
    1655                 1660                 1665             


Lys Leu  Leu Thr Asn Trp Met  Ser Ile Cys Leu Tyr  Thr Phe Val 
    1670                 1675                 1680             


Arg Asp  Ser Val Gly Glu Pro  Leu Tyr Met Leu Phe  Arg Gly Ile 
    1685                 1690                 1695             


Lys His  Gln Val Asp Lys Gly  Pro Val Asp Ser Val  Thr Gly Lys 
    1700                 1705                 1710             


Ala Lys  Tyr Thr Leu Asn Asp  Asn Arg Leu Leu Arg  Glu Asp Val 
    1715                 1720                 1725             


Glu Tyr  Arg Pro Leu Thr Leu  Asn Ala Leu Leu Ala  Val Gly Pro 
    1730                 1735                 1740             


Gly Ala  Gly Glu Ala Gln Cys  Val Pro Val Lys Val  Leu Asp Cys 
    1745                 1750                 1755             


Asp Thr  Ile Ser Gln Ala Lys  Glu Lys Met Leu Asp  Gln Leu Tyr 
    1760                 1765                 1770             


Lys Gly  Val Pro Leu Ala Gln  Arg Pro Asp Ser Cys  Thr Leu Asp 
    1775                 1780                 1785             


Val Glu  Trp Arg Ser Gly Val  Ala Gly His Leu Ile  Leu Ser Asp 
    1790                 1795                 1800             


Glu Asp  Val Thr Ser Glu Leu  Gln Gly Leu Trp Arg  Arg Leu Asn 
    1805                 1810                 1815             


Thr Leu  Gln His Tyr Lys Val  Pro Asp Gly Ala Thr  Val Ala Leu 
    1820                 1825                 1830             


Val Pro  Cys Leu Thr Lys His  Ile Leu Arg Glu Asn  Gln Asp Tyr 
    1835                 1840                 1845             


Val Pro  Gly Glu Arg Thr Pro  Met Leu Glu Asp Val  Asp Glu Gly 
    1850                 1855                 1860             


Gly Ile  Arg Pro Trp His Leu  Val Lys Pro Ser Asp  Glu Pro Glu 
    1865                 1870                 1875             


Pro Pro  Arg Pro Arg Arg Gly  Ser Leu Arg Gly Gly  Glu Arg Glu 
    1880                 1885                 1890             


Arg Ala  Lys Ala Ile Pro Glu  Ile Tyr Leu Thr Arg  Leu Leu Ser 
    1895                 1900                 1905             


Met Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Gln Val 
    1910                 1915                 1920             


Ile Leu  Ser Thr Ser Arg Pro  Val Pro Leu Ala Val  Lys Tyr Phe 
    1925                 1930                 1935             


Phe Asp  Leu Leu Asp Glu Gln  Ala Gln Gln His Gly  Ile Ser Asp 
    1940                 1945                 1950             


Gln Asp  Thr Ile His Ile Trp  Lys Thr Asn Ser Leu  Pro Leu Arg 
    1955                 1960                 1965             


Phe Trp  Ile Asn Ile Ile Lys  Asn Pro Gln Phe Val  Phe Asp Val 
    1970                 1975                 1980             


Gln Thr  Ser Asp Asn Met Asp  Ala Val Leu Leu Val  Ile Ala Gln 
    1985                 1990                 1995             


Thr Phe  Met Asp Ala Cys Thr  Leu Ala Asp His Lys  Leu Gly Arg 
    2000                 2005                 2010             


Asp Ser  Pro Ile Asn Lys Leu  Leu Tyr Ala Arg Asp  Ile Pro Arg 
    2015                 2020                 2025             


Tyr Lys  Gln Met Val Glu Arg  Tyr Tyr Ala Asp Ile  Arg Gln Thr 
    2030                 2035                 2040             


Val Pro  Ala Ser Asp Gln Glu  Met Asn Ser Val Leu  Ala Glu Leu 
    2045                 2050                 2055             


Ser Arg  Asn Cys Ser Ala Asp  Leu Gly Ala Arg Val  Ala Leu His 
    2060                 2065                 2070             


Glu Leu  Tyr Lys Tyr Ile Asn  Lys Tyr Tyr Asp Gln  Ile Ile Thr 
    2075                 2080                 2085             


Ala Leu  Glu Glu Asp Gly Thr  Ala Gln Lys Met Gln  Leu Gly Tyr 
    2090                 2095                 2100             


Arg Leu  Gln Gln Ile Ala Ala  Ala Val Glu Asn Lys  Val Thr Asp 
    2105                 2110                 2115             


Leu 
    


