                         SEQUENCE LISTING

<110>  Sanatris Pharma A/S
 
<120>  ANTIMIR-122 LNA OLIGONUCLEOTIDE CARBOHYDRATE CONJUGATES

<130>  1139WO

<150>  EP13153296.2
<151>  2013-01-30

<150>  EP13157237.2
<151>  2013-02-28

<150>  EP13174092.0
<151>  2013-06-27

<150>  EP13192931.7
<151>  2013-11-14

<150>  EP13192930.9
<151>  2013-11-14

<150>  PCT/EP2013/073859
<151>  2013-11-14

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  LNA nucleosides at position 1, 3, 6, 7, 10, 12, 14 & 15, LNA C 
       are 5-methyl C

<400>  1
ccattgtcac actcc                                                        15


<210>  2
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C are optionally 5-methyl C

<400>  2
acactcc                                                                  7


<210>  3
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  3
cacactcc                                                                 8


<210>  4
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  4
tcacactcc                                                                9


<210>  5
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  beta-D-oxyLNA nucleosides, LNA C are 5-methyl C

<400>  5
tcacactcc                                                                9


<210>  6
<211>  23
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-122

<400>  6
uggaguguga caaugguguu ugu                                               23


<210>  7
<211>  85
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-122

<400>  7
ccuuagcaga gcuguggagu gugacaaugg uguuuguguc uaaacuauca aacgccauua       60

ucacacuaaa uagcuacugc uaggc                                             85


<210>  8
<211>  22
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-122

<400>  8
uggaguguga caaugguguu ug                                                22


<210>  9
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  9
tcagcattgg tattca                                                       16


<210>  10
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  10
cagcattggt attca                                                        15


<210>  11
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (2)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  11
agcattggta ttca                                                         14


<210>  12
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  12
gacgcattgg tattca                                                       16


<210>  13
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  13
gcattggtat tca                                                          13


<210>  14
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc conjugate, e.g Conj1a or conj2a.

<400>  14
cacactcc                                                                 8


<210>  15
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc conjugate, e.g Conj1a or conj2a.

<400>  15
cacactcc                                                                 8


<210>  16
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<400>  16
cacactccca cacactcc                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc conjugate, e.g Conj1a or conj2a.

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<400>  17
cacactccca cacactcc                                                     18


