
                                SEQUENCE LISTING

<110> Zauderer, Maurice
      Yoshida, Masaru
      Yamamoto, Koji
      Smith, Ernest S.

<120> Methods for Increasing Immunoglobulin A Levels
  

<130> 50827-441418

<150> 61/759,108
<151> 2013-01-31

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1201
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (79)...(408)

<400> 1
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga 60
actctacctc cagacaga atg aag ttc atc tcg aca tct ctg ctt ctc atg   111
                    Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met
                     1               5                   10
 
ctg ctg gtc agc agc ctc tct cca gtc caa ggt gtt ctg gag gtc tat   159
Leu Leu Val Ser Ser Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr
             15                  20                  25
 
tac aca agc ttg agg tgt aga tgt gtc caa gag agc tca gtc ttt atc   207
Tyr Thr Ser Leu Arg Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile
         30                  35                  40
 
cct aga cgc ttc att gat cga att caa atc ttg ccc cgt ggg aat ggt   255
Pro Arg Arg Phe Ile Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly
     45                  50                  55
 
tgt cca aga aaa gaa atc ata gtc tgg aag aag aac aag tca att gtg   303
Cys Pro Arg Lys Glu Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val
 60                  65                  70                  75
 
tgt gtg gac cct caa gct gaa tgg ata caa aga atg atg gaa gta ttg   351
Cys Val Asp Pro Gln Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu
                 80                  85                  90
 
aga aaa aga agt tct tca act cta cca gtt cca gtg ttt aag aga aag   399
Arg Lys Arg Ser Ser Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys
             95                 100                 105
 
att ccc tga tgctgatatt tccactaaga acacctgcat tcttccctta           448
Ile Pro  

 
tccctgctct ggattttagt tttgtgctta gttaaatctt ttccaggaaa aagaacttcc 508
ccatacaaat aagcatgaga ctatgtaaaa ataaccttgc agaagctgat ggggcaaact 568
caagcttctt cactcacagc accctatata cacttggagt ttgcattctt attcatcagg 628
gaggaaagtt tctttgaaaa tagttattca gttataagta atacaggatt attttgatta 688
tatacttgtt gtttaatgtt taaaatttct tagaaaacaa tggaatgaga atttaagcct 748
caaatttgaa catgtggctt gaattaagaa gaaaattatg gcatatatta aaagcaggct 808
tctatgaaag actcaaaaag ctgcctggga ggcagatgga acttgagcct gtcaagaggc 868
aaaggaatcc atgtagtaga tatcctctgc ttaaaaactc actacggagg agaattaagt 928
cctactttta aagaatttct ttataaaatt tactgtctaa gattaatagc attcgaagat 988
ccccagactt catagaatac tcagggaaag catttaaagg gtgatgtaca catgtatcct 1048
ttcacacatt tgccttgaca aacttctttc actcacatct ttttcactga ctttttttgt 1108
ggggggcggg gccgggggga ctctggtatc taattcttta atgattccta taaatctaat 1168
gacattcaat aaagttgagc aaacatttta ctt                              1201

<210> 2
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser
 1               5                  10                  15      
Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg
            20                  25                  30          
Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile
        35                  40                  45              
Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu
    50                  55                  60                  
Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln
65                  70                  75                  80  
Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser
                85                  90                  95      
Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro
            100                 105                 


<210> 3
<211> 1162
<212> DNA
<213> Mus musculus

<220> 
<221> CDS            
<222> (33)...(362)

<400> 3
gagctaaagg ttgaactcca cctccaggca ga atg agg ctc agc aca gca acg   53
                                    Met Arg Leu Ser Thr Ala Thr
                                     1               5
 
ctg ctt ctc ctc ctg gcc agc tgc ctc tct cca ggc cac ggt att ctg   101
Leu Leu Leu Leu Leu Ala Ser Cys Leu Ser Pro Gly His Gly Ile Leu
         10                  15                  20
 
gaa gcc cat tac aca aac tta aaa tgt agg tgt tct gga gtg att tca   149
Glu Ala His Tyr Thr Asn Leu Lys Cys Arg Cys Ser Gly Val Ile Ser
     25                  30                  35
 
act gtt gtc ggt cta aac atc ata gat cgg att caa gtt acg ccc cct   197
Thr Val Val Gly Leu Asn Ile Ile Asp Arg Ile Gln Val Thr Pro Pro
 40                  45                  50                  55
 
ggg aat ggc tgc ccc aaa act gaa gtt gtg atc tgg acc aag atg aag   245
Gly Asn Gly Cys Pro Lys Thr Glu Val Val Ile Trp Thr Lys Met Lys
                 60                  65                  70
 
aaa gtt ata tgt gtg aat cct cgt gcc aaa tgg tta caa aga tta tta   293
Lys Val Ile Cys Val Asn Pro Arg Ala Lys Trp Leu Gln Arg Leu Leu
             75                  80                  85
 
aga cat gtc caa agc aaa agt ctg tct tca act ccc caa gct cca gtg   341
Arg His Val Gln Ser Lys Ser Leu Ser Ser Thr Pro Gln Ala Pro Val
         90                  95                 100
 
agt aag aga aga gct gcc tga agccactatc atctcaaaag acacacctgc      392
Ser Lys Arg Arg Ala Ala  
    105
 
accttttttt ttatccctgc tctgaatttt agatatgttc ttagttaaag aatttccaag 452
aaaataactc ccctctacaa acaaacatga ctgtaggtaa aacaaagcaa aaacaaacaa 512
gcaaacaaac aaactaaaaa aaacccaatc ctgcaggagc tgagagggaa tgctcaagct 572
ccgttgcata cccaacccac atccttgttc cttaagaaag gctatttgag aacaggcatt 632
tagtgacaac ccacttcaga tgcatgtggt aatagatctg ttgtttaatg ttaaactatc 692
ctagattgtc gaggaatgaa aaacctacat gtcaaatgtg aacttgtagc tcgtactaac 752
aagaggtttg cgagatggac ttcagttatt ttgcaccctt gtaaaacgca ggcttccaaa 812
atagtctcca gaaggttcct gggaagctgg tgcaatgcca tcatgaggtg gtgcaaagca 872
ggtctccttt agagaaaagc ttcctggggg aaacagtcct actttgaaag gttgcttgta 932
taagatttat tgtcttgcat taaaaccagt aacaattgaa agatcctcag cttaaaggtc 992
caggctcttc agcagtatac aaatatattc ctttgcactg tgaccctgat gatctatttt 1052
tattattcat atctttcaca cagacaaaat accagcctct tgtatcagat tctttaatgt 1112
ttcctattca tctggtgtca ttcaataaat gtaatcaaat gttttgctta            1162

<210> 4
<211> 109
<212> PRT
<213> Mus musculus

<400> 4
Met Arg Leu Ser Thr Ala Thr Leu Leu Leu Leu Leu Ala Ser Cys Leu
 1               5                  10                  15      
Ser Pro Gly His Gly Ile Leu Glu Ala His Tyr Thr Asn Leu Lys Cys
            20                  25                  30          
Arg Cys Ser Gly Val Ile Ser Thr Val Val Gly Leu Asn Ile Ile Asp
        35                  40                  45              
Arg Ile Gln Val Thr Pro Pro Gly Asn Gly Cys Pro Lys Thr Glu Val
    50                  55                  60                  
Val Ile Trp Thr Lys Met Lys Lys Val Ile Cys Val Asn Pro Arg Ala
65                  70                  75                  80  
Lys Trp Leu Gln Arg Leu Leu Arg His Val Gln Ser Lys Ser Leu Ser
                85                  90                  95      
Ser Thr Pro Gln Ala Pro Val Ser Lys Arg Arg Ala Ala
            100                 105                 


<210> 5
<211> 82
<212> PRT
<213> Macaca fascicularis

<400> 5
Val Leu Glu Val Tyr Tyr Thr His Leu Arg Cys Arg Cys Val Gln Glu
 1               5                  10                  15      
Ser Ser Val Phe Ile Pro Arg Arg Phe Ile Asp Arg Ile Gln Ile Ser
            20                  25                  30          
Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu Ile Ile Val Trp Lys Lys
        35                  40                  45              
Asn Lys Ser Val Val Cys Val Asp Pro Gln Ala Glu Trp Ile Gln Arg
    50                  55                  60                  
Ile Met Glu Met Leu Arg Lys Lys Ser Ser Ser Thr Pro Pro Val Pro
65                  70                  75                  80  
Val Phe
        


<210> 6
<211> 2902
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (177)...(1295)

<400> 6
aaaaaaaaaa agtgatgagt tgtgaggcag gtcgcggccc tactgcctca ggagacgatg 60
cgcagctcat ttgcttaaat ttgcagctga cggctgccac ctctctagag gcacctggcg 120
gggagcctct caacataaga cagtgaccag tctggtgact cacagccggc acagcc atg 179
                                                              Met
                                                               1
 
aac tac ccg cta acg ctg gaa atg gac ctc gag aac ctg gag gac ctg   227
Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp Leu
             5                   10                  15
 
ttc tgg gaa ctg gac aga ttg gac aac tat aac gac acc tcc ctg gtg   275
Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu Val
         20                  25                  30
 
gaa aat cat ctc tgc cct gcc aca gag ggg ccc ctc atg gcc tcc ttc   323
Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser Phe
     35                  40                  45
 
aag gcc gtg ttc gtg ccc gtg gcc tac agc ctc atc ttc ctc ctg ggc   371
Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu Gly
 50                  55                  60                  65
 
gtg atc ggc aac gtc ctg gtg ctg gtg atc ctg gag cgg cac cgg cag   419
Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg Gln
                 70                  75                  80
 
aca cgc agt tcc acg gag acc ttc ctg ttc cac ctg gcc gtg gcc gac   467
Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala Asp
             85                  90                  95
 
ctc ctg ctg gtc ttc atc ttg ccc ttt gcc gtg gcc gag ggc tct gtg   515
Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser Val
        100                 105                 110
 
ggc tgg gtc ctg ggg acc ttc ctc tgc aaa act gtg att gcc ctg cac   563
Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu His
    115                 120                 125
 
aaa gtc aac ttc tac tgc agc agc ctg ctc ctg gcc tgc atc gcc gtg   611
Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala Val
130                 135                 140                 145
 
gac cgc tac ctg gcc att gtc cac gcc gtc cat gcc tac cgc cac cgc   659
Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His Arg
                150                 155                 160
 
cgc ctc ctc tcc atc cac atc acc tgt ggg acc atc tgg ctg gtg ggc   707
Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val Gly
            165                 170                 175
 
ttc ctc ctt gcc ttg cca gag att ctc ttc gcc aaa gtc agc caa ggc   755
Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln Gly
        180                 185                 190
 
cat cac aac aac tcc ctg cca cgt tgc acc ttc tcc caa gag aac caa   803
His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn Gln
    195                 200                 205
 
gca gaa acg cat gcc tgg ttc acc tcc cga ttc ctc tac cat gtg gcg   851
Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val Ala
210                 215                 220                 225
 
gga ttc ctg ctg ccc atg ctg gtg atg ggc tgg tgc tac gtg ggg gta   899
Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly Val
                230                 235                 240
 
gtg cac agg ttg cgc cag gcc cag cgg cgc cct cag cgg cag aag gca   947
Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys Ala
            245                 250                 255
 
gtc agg gtg gcc atc ctg gtg aca agc atc ttc ttc ctc tgc tgg tca   995
Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp Ser
        260                 265                 270
 
ccc tac cac atc gtc atc ttc ctg gac acc ctg gcg agg ctg aag gcc   1043
Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys Ala
    275                 280                 285
 
gtg gac aat acc tgc aag ctg aat ggc tct ctc ccc gtg gcc atc acc   1091
Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile Thr
290                 295                 300                 305
 
atg tgt gag ttc ctg ggc ctg gcc cac tgc tgc ctc aac ccc atg ctc   1139
Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met Leu
                310                 315                 320
 
tac act ttc gcc ggc gtg aag ttc cgc agt gac ctg tcg cgg ctc ctg   1187
Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu Leu
            325                 330                 335
 
acg aag ctg ggc tgt acc ggc cct gcc tcc ctg tgc cag ctc ttc cct   1235
Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe Pro
        340                 345                 350
 
agc tgg cgc agg agc agt ctc tct gag tca gag aat gcc acc tct ctc   1283
Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser Leu
    355                 360                 365
 
acc acg ttc tag gtcccagtgt ccccttttat tgctgctttt ccttggggca       1335
Thr Thr Phe  
370
 
ggcagtgatg ctggatgctc cttccaacag gagctgggat cctaagggct caccgtggct 1395
aagagtgtcc taggagtatc ctcatttggg gtagctagag gaaccaaccc ccatttctag 1455
aacatccctg ccagctcttc tgccggccct ggggctaggc tggagcccag ggagcggaaa 1515
gcagctcaaa ggcacagtga aggctgtcct tacccatctg cacccccctg ggctgagaga 1575
acctcacgca cctcccatcc taatcatcca atgctcaaga aacaacttct acttctgccc 1635
ttgccaacgg agagcgcctg cccctcccag aacacactcc atcagcttag gggctgctga 1695
cctccacagc ttcccctctc tcctcctgcc cacctgtcaa acaaagccag aagctgagca 1755
ccaggggatg agtggaggtt aaggctgagg aaaggccagc tggcagcaga gtgtggcctt 1815
cggacaactc agtccctaaa aacacagaca ttctgccagg cccccaagcc tgcagtcatc 1875
ttgaccaagc aggaagctca gactggttga gttcaggtag ctgcccctgg ctctgaccga 1935
aacagcgctg ggtccacccc atgtcaccgg atcctgggtg gtctgcaggc agggctgact 1995
ctaggtgccc ttggaggcca gccagtgacc tgaggaagcg tgaaggccga gaagcaagaa 2055
agaaacccga cagagggaag aaaagagctt tcttcccgaa ccccaaggag ggagatggat 2115
caatcaaacc cggcggtccc ctccgccagg cgagatgggg tggggtggag aactcctagg 2175
gtggctgggt ccaggggatg ggaggttgtg ggcattgatg gggaaggagg ctggcttgtc 2235
ccctcctcac tcccttccca taagctatag acccgaggaa actcagagtc ggaacggaga 2295
aaggtggact ggaaggggcc cgtgggagtc atctcaacca tcccctccgt ggcatcacct 2355
taggcaggga agtgtaagaa acacactgag gcagggaagt ccccaggccc caggaagccg 2415
tgccctgccc ccgtgaggat gtcactcaga tggaaccgca ggaagctgct ccgtgcttgt 2475
ttgctcacct ggggtgtggg aggcccgtcc ggcagttctg ggtgctccct accacctccc 2535
cagcctttga tcaggtgggg agtcagggac ccctgccctt gtcccactca agccaagcag 2595
ccaagctcct tgggaggccc cactggggaa ataacagctg tggctcacgt gagagtgtct 2655
tcacggcagg acaacgagga agccctaaga cgtccctttt ttctctgagt atctcctcgc 2715
aagctgggta atcgatgggg gagtctgaag cagatgcaaa gaggcaagag gctggatttt 2775
gaattttctt tttaataaaa aggcacctat aaaacaggtc aatacagtac aggcagcaca 2835
gagacccccg gaacaagcct aaaaattgtt tcaaaataaa aaccaagaag atgtcttcac 2895
atattgt                                                           2902

<210> 7
<211> 372
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp
 1               5                  10                  15      
Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu
            20                  25                  30          
Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser
        35                  40                  45              
Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu
    50                  55                  60                  
Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg
65                  70                  75                  80  
Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala
                85                  90                  95      
Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser
            100                 105                 110         
Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu
        115                 120                 125             
His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala
    130                 135                 140                 
Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His
145                 150                 155                 160 
Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val
                165                 170                 175     
Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln
            180                 185                 190         
Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn
        195                 200                 205             
Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val
    210                 215                 220                 
Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly
225                 230                 235                 240 
Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys
                245                 250                 255     
Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp
            260                 265                 270         
Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys
        275                 280                 285             
Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile
    290                 295                 300                 
Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met
305                 310                 315                 320 
Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu
                325                 330                 335     
Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe
            340                 345                 350         
Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser
        355                 360                 365             
Leu Thr Thr Phe
    370         


<210> 8
<211> 2614
<212> DNA
<213> Mus musculus

<220> 
<221> CDS            
<222> (44)...(1168)

<400> 8
cgacatcaga cagtgaccag cctggtgacg cagagctgca gct atg aac tac cca   55
                                                Met Asn Tyr Pro
                                                 1
 
cta acc ctg gac atg ggc tcc atc aca tac aat atg gat gac ctg tac   103
Leu Thr Leu Asp Met Gly Ser Ile Thr Tyr Asn Met Asp Asp Leu Tyr
 5                   10                  15                  20
 
aag gaa ctg gcc ttc tac agt aac agc acg gag att ccc cta cag gac   151
Lys Glu Leu Ala Phe Tyr Ser Asn Ser Thr Glu Ile Pro Leu Gln Asp
                 25                  30                  35
 
agt aac ttc tgc tct aca gtc gag gga ccc tta ctg acg tcc ttt aag   199
Ser Asn Phe Cys Ser Thr Val Glu Gly Pro Leu Leu Thr Ser Phe Lys
             40                  45                  50
 
gcg gta ttc atg cct gtg gcc tac agc ctc atc ttc ctc ctg ggt atg   247
Ala Val Phe Met Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu Gly Met
         55                  60                  65
 
atg gga aac atc ctg gtg ctg gta atc ctg gag agg cac cgg cac act   295
Met Gly Asn Ile Leu Val Leu Val Ile Leu Glu Arg His Arg His Thr
     70                  75                  80
 
cgg agc tca acc gag acc ttc ctg ttc cac ctc gca gta gcc gac ctt   343
Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala Asp Leu
 85                  90                  95                 100
 
ctc tta gtc ttc atc ctg cct ttt gca gtg gct gag ggc tct gtg ggt   391
Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser Val Gly
                105                 110                 115
 
tgg gtc cta ggg acc ttc ctc tgc aaa act gtg atc gct ctg cac aag   439
Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu His Lys
            120                 125                 130
 
atc aat ttc tac tgc agc agc ctg ctg ctg gcc tgt ata gct gta gac   487
Ile Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala Val Asp
        135                 140                 145
 
cgg tac cta gcc atc gtc cat gct gtt cac gcc tac cgc cgc cgt cga   535
Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg Arg Arg Arg
    150                 155                 160
 
ctc ctc tcc atc cac atc acc tgc acg gcc att tgg ctg gcc ggc ttc   583
Leu Leu Ser Ile His Ile Thr Cys Thr Ala Ile Trp Leu Ala Gly Phe
165                 170                 175                 180
 
ctg ttc gcc tta ccg gaa ctc ctc ttt gcc aag gtt ggc caa cct cat   631
Leu Phe Ala Leu Pro Glu Leu Leu Phe Ala Lys Val Gly Gln Pro His
                185                 190                 195
 
aac aac gac tcc tta cca cag tgc acc ttc tcc cag gaa aac gaa gcg   679
Asn Asn Asp Ser Leu Pro Gln Cys Thr Phe Ser Gln Glu Asn Glu Ala
            200                 205                 210
 
gaa act aga gcc tgg ttc acc tcc cgt ttc ctc tac cac atc ggg ggc   727
Glu Thr Arg Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Ile Gly Gly
        215                 220                 225
 
ttc cta cta ccg atg ctt gtg atg gga tgg tgt tac gtg ggc gtg gtc   775
Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly Val Val
    230                 235                 240
 
cac agg cta ctg cag gcc cag cgg cgc cct cag cgg cag aag gcg gtc   823
His Arg Leu Leu Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys Ala Val
245                 250                 255                 260
 
agg gtg gcc att tta gtg aca agc att ttc ttc ctc tgc tgg tcg ccc   871
Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp Ser Pro
                265                 270                 275
 
tac cac att gtc atc ttc cta gat aca ctg gag agg ctg aag gct gtg   919
Tyr His Ile Val Ile Phe Leu Asp Thr Leu Glu Arg Leu Lys Ala Val
            280                 285                 290
 
aat agc agc tgc gag ctg agt ggc tat ctc tct gtg gcc atc acc ttg   967
Asn Ser Ser Cys Glu Leu Ser Gly Tyr Leu Ser Val Ala Ile Thr Leu
        295                 300                 305
 
tgt gaa ttc ctg ggc ctg gca cac tgc tgt ctc aat ccc atg ctc tac   1015
Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met Leu Tyr
    310                 315                 320
 
acc ttc gct ggc gta aag ttc cgc agt gac ctc tct cgg ctt ctg acc   1063
Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu Leu Thr
325                 330                 335                 340
 
aag ctg ggc tgt gct ggc ccg gcc tcc ctt tgc caa ctt ttc ccc aac   1111
Lys Leu Gly Cys Ala Gly Pro Ala Ser Leu Cys Gln Leu Phe Pro Asn
                345                 350                 355
 
tgg cgc aag agt agt ctc tct gag tca gag aat gct act tcc ctc acc   1159
Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser Leu Thr
            360                 365                 370
 
acc ttc tag atcccggaag tctcggggcc cctgtctgtt tctgttttcc           1208
Thr Phe  

 
ttgggaggat aaagtggtgg cggaacccat ccaactcgag cttgggccag tgtccccaga 1268
tgggaaagct agataaactc tctcaaactt tcccaaaggg gaaagcagcc caaaggcaaa 1328
gcaagctata tccaggccac ctgtatcacc ttagatgaag agaactccat acacctccca 1388
tcctaaccag ctaaagctaa gctcagcttt atttcttcct ggccataggg acaaccacct 1448
ctgctgtggc ccacagtctc atcttcctcc tgattatgag cccagactct cctcccagaa 1508
tgtattccat catcttaaag actactggct gccacagcta cccaccactc ctataccaca 1568
gaggaatagc cagctggcgg cggcagacta tggccttaat gtgcctgtct cataaataca 1628
gacttcatgc cagaccttca accgtgcctt tctcttaacc aagcagaaag ctgaaaccga 1688
tctactttag gtagctgtct ggttccaacc taaccagcat tgggtcagcc ccatgttact 1748
ggatcttgga ttacagactg agggcaagtt ccagaaggtt ctggaagcta gccagtatcc 1808
taagaagagt aaagggcaag ccagcaggaa agaggcccag tggaaaagtg gaaagacacc 1868
ttttccaggc tctaaggaag aacaagtaaa aatcaaaccc agctgtcttc tccacccaat 1928
gtaccaaagc ttacagactg gtggggaaat gagatccagg gccctcgtgg attctacgca 1988
ccaatgggga aggaagccaa cttgcctggg gaaagcaaga tagcaaagtg gtcctagcct 2048
cgagagaggg gacacctagc taagagaatg acgacagagg ttcctgtctt cattaggcag 2108
aggcaatata agaagccaac ctgggcaggc aagtcctcaa accccaggaa ggcagtaccc 2168
tgcccctggg agggtaccac tcacatggaa ccagaggaag ctgctccatg catacatagg 2228
ggaagttagc aggcaattct gagctcggct tcctcccagc caccgatctg ggggcgtggg 2288
ggtaggaagc agagttgcct agtaccactc aagccaaccg tacaagctcc ctgggggatc 2348
ccactgggga aaccaatgct atagcttcag agactgtatc ctcattgcag aaccgtgaag 2408
acacctgggg accccctttt ctgctcccag catccaacaa ccagctggga agaggcaaac 2468
cgggcacaga aataaaaatg caagagatgg catttttgaa ttttctcttt ttaataaaaa 2528
ggcacctata aaacaggtca atacaggcag agacccccgg aacaagccta aaaagtgttt 2588
caaaataaaa acaggaagat gtcttc                                      2614

<210> 9
<211> 374
<212> PRT
<213> Mus musculus

<400> 9
Met Asn Tyr Pro Leu Thr Leu Asp Met Gly Ser Ile Thr Tyr Asn Met
 1               5                  10                  15      
Asp Asp Leu Tyr Lys Glu Leu Ala Phe Tyr Ser Asn Ser Thr Glu Ile
            20                  25                  30          
Pro Leu Gln Asp Ser Asn Phe Cys Ser Thr Val Glu Gly Pro Leu Leu
        35                  40                  45              
Thr Ser Phe Lys Ala Val Phe Met Pro Val Ala Tyr Ser Leu Ile Phe
    50                  55                  60                  
Leu Leu Gly Met Met Gly Asn Ile Leu Val Leu Val Ile Leu Glu Arg
65                  70                  75                  80  
His Arg His Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala
                85                  90                  95      
Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu
            100                 105                 110         
Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile
        115                 120                 125             
Ala Leu His Lys Ile Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys
    130                 135                 140                 
Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr
145                 150                 155                 160 
Arg Arg Arg Arg Leu Leu Ser Ile His Ile Thr Cys Thr Ala Ile Trp
                165                 170                 175     
Leu Ala Gly Phe Leu Phe Ala Leu Pro Glu Leu Leu Phe Ala Lys Val
            180                 185                 190         
Gly Gln Pro His Asn Asn Asp Ser Leu Pro Gln Cys Thr Phe Ser Gln
        195                 200                 205             
Glu Asn Glu Ala Glu Thr Arg Ala Trp Phe Thr Ser Arg Phe Leu Tyr
    210                 215                 220                 
His Ile Gly Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr
225                 230                 235                 240 
Val Gly Val Val His Arg Leu Leu Gln Ala Gln Arg Arg Pro Gln Arg
                245                 250                 255     
Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu
            260                 265                 270         
Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Glu Arg
        275                 280                 285             
Leu Lys Ala Val Asn Ser Ser Cys Glu Leu Ser Gly Tyr Leu Ser Val
    290                 295                 300                 
Ala Ile Thr Leu Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn
305                 310                 315                 320 
Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser
                325                 330                 335     
Arg Leu Leu Thr Lys Leu Gly Cys Ala Gly Pro Ala Ser Leu Cys Gln
            340                 345                 350         
Leu Phe Pro Asn Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala
        355                 360                 365             
Thr Ser Leu Thr Thr Phe
    370                 


<210> 10
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> H1609; VH domain of 3D2 antibody

<400> 10
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln
 1               5                  10                  15      
Thr Leu Asn Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Arg Arg Tyr Asn Pro Ala
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Glu Thr Ser Lys Asn Gln Val
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
                85                  90                  95      
Cys Thr Arg Ile Ala Gly Tyr Tyr Gly Ser Arg Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120             


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> H1609-CDR1

<400> 11
Thr Phe Gly Met Gly Val Gly
 1               5          


<210> 12
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> H1609-CDR2

<400> 12
His Ile Trp Trp Asp Asp Asp Arg Arg Tyr Asn Pro Ala Leu Lys Ser
 1               5                  10                  15      


<210> 13
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> H1609-CDR3

<400> 13
Ile Ala Gly Tyr Tyr Gly Ser Arg Asp Trp Phe Ala Tyr
 1               5                  10              


<210> 14
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> H5188/H2177; VH domain from MAb 5378 and 5261

<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Phe
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Ala His Ile Trp Trp Asp Asp Asp Arg Arg Tyr Asn Pro Ala
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Ile Ala Gly Tyr Tyr Gly Ser Arg Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120             


<210> 15
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> L0293; VL domain from MAb 3D2

<400> 15
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Lys Leu Leu Ile Phe Arg Ala Ser Asp Leu Glu Ser Gly Ile Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Val Asn
65                  70                  75                  80  
Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser Asn
                85                  90                  95      
Lys Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> L0293-CDR1

<400> 16
Arg Ala Ser Glu Ser Val Asp Asn Ser Gly Ile Ser Phe Met His
 1               5                  10                  15  


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> L0293-CDR2

<400> 17
Arg Ala Ser Asp Leu Glu Ser
 1               5          


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> L0293-CDR3

<400> 18
Gln Gln Ser Asn Lys Asp Pro Trp Thr
 1               5                  


<210> 19
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> L5153/L5140; VL domains from MAb 5378 and 5261

<400> 19
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Met
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
        35                  40                  45              
Lys Leu Leu Ile Phe Arg Ala Ser Asp Leu Glu Ser Gly Val Pro Ser
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Lys Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> L5153-CDR1

<400> 20
Arg Ala Ser Glu Ser Val Asp Asn Met Gly Ile Ser Phe Met His
 1               5                  10                  15  


<210> 21
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> L5055; VL domain of MAb 5080

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Ser
            20                  25                  30          
Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
        35                  40                  45              
Lys Leu Leu Ile Phe Arg Ala Ser Asp Leu Glu Ser Gly Val Pro Ser
    50                  55                  60                  
Gly Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                85                  90                  95      
Lys Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110   


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> H. suis 16S rRNA forward primer

<400> 22
ttgggaggct ttgtctttcc a                                           21

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> H. suis 16S rRNA reverse primer

<400> 23
gattagctct gcctcgcggc t                                           21

<210> 24
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> TGF-beta sense primer

<400> 24
tcttggtcca gatcacaact tca                                         23

<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> TGF-beta antisense primer

<400> 25
cactgatacg cctgagtgr                                              19

<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-6 sense primer

<400> 26
gtgagcgctg aatcgaaa                                               18

<210> 27
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-6 antisense primer

<400> 27
gaggatacca ctcccaacag acc                                         23

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> beta-actin sense primer

<400> 28
atcactgacg ctgattgcac                                             20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> beta-actin antisense primer

<400> 29
aaggccaacc gtgaaaagat                                             20  




