                         SEQUENCE LISTING

<110>  Thomas Jefferson University
 
<120>  FUSION PROTEINS THAT FACILITATE CANCER CELL DESTRUCTION

<130>  37075_0292_00_WO

<150>  US 61/759,301
<151>  2013-01-31

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Val Ala Gly Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser 
1               5                   10                  15      


Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr 
            20                  25                  30          


Ser Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro 
        35                  40                  45              


Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val 
    50                  55                  60                  


Thr Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile 
65                  70                  75                  80  


Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val 
                85                  90                  95      


Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala 
            100                 105                 110         


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser 
        115                 120                 125             


Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys 
    130                 135                 140                 


Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys 
145                 150                 155                 160 


Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly 
                165                 170                 175     


Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr 
            180                 185                 190         


Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr 
        195                 200                 205             


Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile 
    210                 215                 220                 


Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu 
225                 230                 235                 240 


Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg 
                245                 250                 255     


Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr 
            260                 265                 270         


Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser 
        275                 280                 285             


Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr 
    290                 295                 300                 


Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp 
305                 310                 315                 320 


Leu Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala 
                325                 330                 335     


Glu Asn Thr Gly Ser Asn Glu Arg Asn Ile Tyr 
            340                 345         


<210>  2
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val 
1               5                   10                  15      


Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile 
            20                  25                  30          


Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu 
        35                  40                  45              


Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val 
    50                  55                  60                  


Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly 
65                  70                  75                  80  


Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg 
                85                  90                  95      


Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu 
            100                 105                 110         


Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala 
        115                 120                 125             


Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His 
    130                 135                 140                 


Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn 
145                 150                 155                 160 


Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val 
                165                 170                 175     


Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp 
            180                 185                 190         


Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly 
        195                 200                 205             


Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro 
    210                 215                 220                 


Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val 
225                 230                 235                 240 


Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu 
                245                 250                 255     


Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr 
            260                 265                 270         


Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu 
        275                 280                 285             


Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val 
    290                 295                 300                 


Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val 
305                 310                 315                 320 


Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr 
                325                 330                 335     


Gly Ser Asn Glu Arg 
            340     


<210>  3
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Ala Gly Glu Glu Glu Leu Gln Met Ile Gln Pro Glu Lys Leu Leu 
1               5                   10                  15      


Leu Val Thr Val Gly Lys Thr Ala Thr Leu His Cys Thr Val Thr Ser 
            20                  25                  30          


Leu Leu Pro Val Gly Pro Val Leu Trp Phe Arg Gly Val Gly Pro Gly 
        35                  40                  45              


Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr 
    50                  55                  60                  


Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg 
65                  70                  75                  80  


Ile Ser Ser Ile Thr Pro Ala Asp Val Gly Thr Tyr Tyr Cys Val Lys 
                85                  90                  95      


Phe Arg Lys Gly Ser Pro Glu Asn Val Glu Phe Lys Ser Gly Pro Gly 
            100                 105                 110         


Thr Glu Met Ala Leu Gly Ala Lys Pro Ser Ala Pro Val Val Leu Gly 
        115                 120                 125             


Pro Ala Ala Arg Thr Thr Pro Glu His Thr Val Ser Phe Thr Cys Glu 
    130                 135                 140                 


Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn 
145                 150                 155                 160 


Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Thr Gly Gln 
                165                 170                 175     


Ser Val Ala Tyr Ser Ile Arg Ser Thr Ala Arg Val Val Leu Asp Pro 
            180                 185                 190         


Trp Asp Val Arg Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu 
        195                 200                 205             


Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg 
    210                 215                 220                 


Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Met Arg Val Gly Asn 
225                 230                 235                 240 


Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Ser Leu 
                245                 250                 255     


Gln Leu Thr Trp Ser Glu Asn Gly Asn Val Cys Gln Arg Glu Thr Ala 
            260                 265                 270         


Ser Thr Leu Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Thr Ser Trp 
        275                 280                 285             


Phe Leu Val Asn Ile Ser Asp Gln Arg Asp Asp Val Val Leu Thr Cys 
    290                 295                 300                 


Gln Val Lys His Asp Gly Gln Leu Ala Val Ser Lys Arg Leu Ala Leu 
305                 310                 315                 320 


Glu Val Thr Val His Gln Lys Asp Gln Ser Ser Asp 
                325                 330         


<210>  4
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Gly Ser Ala Cys Cys Gly Ser Ala Gln Leu Leu Phe Asn Lys Thr 
1               5                   10                  15      


Lys Ser Val Glu Phe Thr Phe Cys Asn Asp Thr Val Val Ile Pro Cys 
            20                  25                  30          


Phe Val Thr Asn Met Glu Ala Gln Asn Thr Thr Glu Val Tyr Val Lys 
        35                  40                  45              


Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr Phe Asp Gly Ala Leu Asn 
    50                  55                  60                  


Lys Ser Thr Val Pro Thr Asp Phe Ser Ser Ala Lys Ile Glu Val Ser 
65                  70                  75                  80  


Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys Met Asp Lys Ser Asp Ala 
                85                  90                  95      


Val Ser His Thr Gly Asn Tyr Thr Cys Glu Val Thr Glu Leu Thr Arg 
            100                 105                 110         


Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr Arg Val Val Ser Trp Phe 
        115                 120                 125             


Ser Pro Asn Glu Asn 
    130             


<210>  5
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn 
        115                 120                 


<210>  6
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  7
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu 
1               5                   10                  15      


Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
            20                  25                  30          


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
        35                  40                  45              


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
    50                  55                  60                  


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
65                  70                  75                  80  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
                85                  90                  95      


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
            100                 105                 110         


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
        115                 120                 125             


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
    130                 135                 140                 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
145                 150                 155                 160 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
                165                 170                 175     


Phe Phe Gly Ala Phe Leu Val Gly 
            180                 


<210>  8
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
1               5                   10                  15      


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
            20                  25                  30          


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
        35                  40                  45              


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
    50                  55                  60                  


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
65                  70                  75                  80  


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
                85                  90                  95      


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
            100                 105                 110         


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
        115                 120                 125             


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
    130                 135                 140                 


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
145                 150                 155                 160 


Ala Phe Leu Val Gly 
                165 


<210>  9
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  10
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu Ser Glu Gln Ile Asp Asn 
        275                 280                 285         


<210>  11
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu 
1               5                   10                  15      


Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met 
            20                  25                  30          


Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val 
        35                  40                  45              


Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe 
    50                  55                  60                  


Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro 
65                  70                  75                  80  


Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu 
                85                  90                  95      


Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met 
            100                 105                 110         


Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala 
        115                 120                 125             


Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu 
    130                 135                 140                 


Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
145                 150                 155 


<210>  12
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu 
1               5                   10                  15      


Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro 
            20                  25                  30          


Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys 
        35                  40                  45              


Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val 
    50                  55                  60                  


Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu 
65                  70                  75                  80  


Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val 
                85                  90                  95      


Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp 
            100                 105                 110         


Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp 
        115                 120                 125             


His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu 
    130                 135                 140                 


Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
145                 150                 


<210>  13
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIRP alpha/TRAIL fusion protein

<400>  13

Gly Val Ala Gly Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser 
1               5                   10                  15      


Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr 
            20                  25                  30          


Ser Leu Ile Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro 
        35                  40                  45              


Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val 
    50                  55                  60                  


Thr Thr Val Ser Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile 
65                  70                  75                  80  


Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val 
                85                  90                  95      


Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala 
            100                 105                 110         


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser 
        115                 120                 125             


Gly Pro Ala Ala Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys 
    130                 135                 140                 


Glu Ser His Gly Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys 
145                 150                 155                 160 


Asn Gly Asn Glu Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly 
                165                 170                 175     


Glu Ser Val Ser Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr 
            180                 185                 190         


Arg Glu Asp Val His Ser Gln Val Ile Cys Glu Val Ala His Val Thr 
        195                 200                 205             


Leu Gln Gly Asp Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile 
    210                 215                 220                 


Arg Val Pro Pro Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu 
225                 230                 235                 240 


Asn Gln Val Asn Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg 
                245                 250                 255     


Leu Gln Leu Thr Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr 
            260                 265                 270         


Ala Ser Thr Val Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser 
        275                 280                 285             


Trp Leu Leu Val Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr 
    290                 295                 300                 


Cys Gln Val Glu His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp 
305                 310                 315                 320 


Leu Lys Val Ser Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala 
                325                 330                 335     


Glu Asn Thr Gly Ser Asn Glu Arg Asn Ile Tyr Gly Asp Pro Leu Val 
            340                 345                 350         


Thr Ala Ala Ser Val Leu Glu Phe Gly Gly Ser Gly Gly Gly Ser Glu 
        355                 360                 365             


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Asp Ile 
    370                 375                 380                 


Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
385                 390                 395                 400 


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
                405                 410                 415     


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
            420                 425                 430         


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
        435                 440                 445             


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
    450                 455                 460                 


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
465                 470                 475                 480 


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
                485                 490                 495     


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
            500                 505                 510         


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
        515                 520                 525             


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
    530                 535                 540                 


Phe Phe Gly Ala Phe Leu Val Gly 
545                 550         


<210>  14
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SIRP alpha/TRAIL fusion protein

<400>  14

Ala Ser His His His His His His Met Gly Val Ala Gly Glu Glu Glu 
1               5                   10                  15      


Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly Glu 
            20                  25                  30          


Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly Pro 
        35                  40                  45              


Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr Asn 
    50                  55                  60                  


Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu Thr 
65                  70                  75                  80  


Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr Pro 
                85                  90                  95      


Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser Pro 
            100                 105                 110         


Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg 
        115                 120                 125             


Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala Thr 
    130                 135                 140                 


Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro 
145                 150                 155                 160 


Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser Asp 
                165                 170                 175     


Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser Ile 
            180                 185                 190         


His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser Gln 
        195                 200                 205             


Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu Arg 
    210                 215                 220                 


Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu Glu 
225                 230                 235                 240 


Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr Cys 
                245                 250                 255     


Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 
            260                 265                 270         


Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu Asn 
        275                 280                 285             


Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val Ser 
    290                 295                 300                 


Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp Gly 
305                 310                 315                 320 


Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His Pro 
                325                 330                 335     


Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn Glu 
            340                 345                 350         


Arg Asn Ile Tyr Gly Asp Pro Leu Val Thr Ala Ala Ser Val Leu Glu 
        355                 360                 365             


Phe Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly 
    370                 375                 380                 


Gly Ser Glu Gly Gly Gly Ser Asp Ile Val Arg Glu Arg Gly Pro Gln 
385                 390                 395                 400 


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
                405                 410                 415     


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
            420                 425                 430         


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
        435                 440                 445             


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
    450                 455                 460                 


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
465                 470                 475                 480 


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
                485                 490                 495     


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
            500                 505                 510         


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
        515                 520                 525             


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
    530                 535                 540                 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
545                 550                 555                 560 


Gly 
    


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  16

Gly Gly Gly Gly Ser 
1               5   


<210>  17
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Gly Asp Pro Leu Val Thr Ala Ala Ser Val Leu Glu Phe Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
            20                  25                  30          


Gly Gly Ser Asp Ile 
        35          


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region of human IgG1 linker

<400>  18

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  19
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro 
                245         


<210>  20
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  purification tag

<400>  21

Ala Ser His His His His His His Met 
1               5                   


<210>  22
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization sequence

<400>  22

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Arg Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Tyr Ile Pro Glu 
            20                  25                  30          


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Arg Gly Glu Trp Val 
        35                  40                  45              


Leu Leu Ser Thr Phe Leu 
    50                  


<210>  23
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trimerization sequence

<400>  23

Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn Lys 
1               5                   10                  15      


Glu Leu Ala Asn Glu Leu Arg Arg 
            20                  


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell binding domain of thrombospondin-1

<400>  24

Arg Phe Tyr Val Val Met Trp Lys 
1               5               


