﻿               SEQUENCE LISTING

<110>  RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG

<120>  ABHD5 and partial HDAC4 fragments and variants as therapeutic approach for the treatment of cardiovascular diseases

<130>  789-4 PCT

<150>  US61/765,440
<151>  2013-02-15

<160> 22

<170> BiSSAP 1.0

<210> 1
<211> 349
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..349
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Met Ala Ala Glu Glu Glu Glu Val Asp Ser Ala Asp Thr Gly Glu Arg 
1               5                   10                   15    
Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Ile 
            20                   25                  30        
Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val Pro Cys 
        35                   40                  45            
Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Lys Ile Trp 
    50                   55                  60                
Thr Leu Lys Phe Ser His Asn Ile Ser Asn Lys Thr Pro Leu Val Leu 
65                   70                  75                  80
Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                   90                  95    
Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                  105                110        
Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu Val Glu 
        115                  120                125            
Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                  135                140                
Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                  150                155                  160
Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Asn His Leu Ile Leu Val 
                165                  170                175    
Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Asp Arg 
            180                  185                190        
Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                  200                205            
Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                  215                220                
Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                  230                235                  240
Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                  250                255    
Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                  265                270        
Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Lys Met His Pro Asp Ile 
        275                  280                285            
Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                  295                300                
Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                  310                315                  320
Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Glu 
                325                  330                335    
Phe Asn Gln Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                  345                

<210> 2
<211> 349
<212> PRT
<213> Pongo abelii

<220> 
<221> SOURCE
<222> 1..349
<223> /mol_type="protein"
      /organism="Pongo abelii"

<400> 2
Met Ala Ala Glu Glu Glu Glu Val Asp Ser Ala Asp Thr Gly Glu Arg 
1               5                   10                   15    
Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Thr 
            20                   25                  30        
Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val Pro Cys 
        35                   40                  45            
Thr Tyr Lys Lys Glu Pro Val His Ile Ser Asn Gly Asn Lys Ile Trp 
    50                   55                  60                
Thr Leu Lys Phe Ser His Asn Ile Ser Asn Lys Thr Pro Leu Val Leu 
65                   70                  75                  80
Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                   90                  95    
Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                  105                110        
Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu Val Glu 
        115                  120                125            
Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                  135                140                
Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                  150                155                  160
Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Asn His Leu Ile Leu Val 
                165                  170                175    
Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Asp Arg 
            180                  185                190        
Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                  200                205            
Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                  215                220                
Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                  230                235                  240
Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                  250                255    
Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                  265                270        
Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Lys Met His Pro Asp Ile 
        275                  280                285            
Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                  295                300                
Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                  310                315                  320
Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Glu 
                325                  330                335    
Phe Asn Gln Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                  345                

<210> 3
<211> 351
<212> PRT
<213> Mus musculus

<220> 
<221> SOURCE
<222> 1..351
<223> /mol_type="protein"
      /organism="Mus musculus"

<400> 3
Met Lys Ala Met Ala Ala Glu Glu Glu Val Asp Ser Ala Asp Ala Gly 
1               5                   10                   15    
Gly Gly Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr 
            20                   25                  30        
Ser Thr Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val 
        35                   40                  45            
Pro Cys Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Arg 
    50                   55                  60                
Ile Trp Thr Leu Met Phe Ser His Asn Ile Ser Ser Lys Thr Pro Leu 
65                   70                  75                  80
Val Leu Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn 
                85                   90                  95    
Phe Glu Asp Leu Ser Thr Asp Arg Pro Val Tyr Ala Phe Asp Leu Leu 
            100                  105                110        
Gly Phe Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu 
        115                  120                125            
Val Glu Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu 
    130                  135                140                
Arg Leu Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu 
145                  150                155                  160
Ala Ala Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Ser His Leu Ile 
                165                  170                175    
Leu Val Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln 
            180                  185                190        
Glu Arg Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr 
        195                  200                205            
Pro Phe Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu 
    210                  215                220                
Ser Leu Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser 
225                  230                235                  240
Met Phe Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val 
                245                  250                255    
Gln Thr Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr 
            260                  265                270        
Gly Trp Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Gly Leu His Pro 
        275                  280                285            
Asp Ile Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly 
    290                  295                300                
Asn Ser Gly Thr Ser Ile Gln Ser Leu Arg Pro Lys Ser Tyr Val Lys 
305                  310                315                  320
Thr Ile Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro 
                325                  330                335    
Glu Glu Phe Asn Gln Lys Val Lys Glu Ile Cys His Thr Val Asp 
            340                  345                350    

<210> 4
<211> 351
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..351
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 4
Met Lys Ala Met Ala Ala Glu Glu Glu Val Asp Ser Ala Asp Ala Gly 
1               5                   10                   15    
Gly Gly Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr 
            20                   25                  30        
Ser Thr Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val 
        35                   40                  45            
Pro Cys Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Ser 
    50                   55                  60                
Ile Trp Thr Leu Met Phe Ser His Asn Met Ser Ser Lys Thr Pro Leu 
65                   70                  75                  80
Val Leu Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn 
                85                   90                  95    
Phe Glu Asp Leu Ser Thr Asp Arg Pro Val Tyr Ala Phe Asp Leu Leu 
            100                  105                110        
Gly Phe Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu 
        115                  120                125            
Val Glu Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu 
    130                  135                140                
Arg Leu Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu 
145                  150                155                  160
Ala Ala Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Ser His Leu Ile 
                165                  170                175    
Leu Val Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln 
            180                  185                190        
Glu Arg Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr 
        195                  200                205            
Pro Phe Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu 
    210                  215                220                
Ser Leu Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser 
225                  230                235                  240
Met Phe Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val 
                245                  250                255    
Gln Thr Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr 
            260                  265                270        
Gly Trp Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Gly Leu His Pro 
        275                  280                285            
Asp Ile Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly 
    290                  295                300                
Asn Ser Gly Thr Ser Ile Gln Ser Leu Arg Pro Lys Ser Tyr Val Lys 
305                  310                315                  320
Thr Ile Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro 
                325                  330                335    
Glu Glu Phe Asn Gln Lys Val Lys Glu Ile Cys His Thr Val Asp 
            340                  345                350    

<210> 5
<211> 349
<212> PRT
<213> Sus scrofa

<220> 
<221> SOURCE
<222> 1..349
<223> /mol_type="protein"
      /organism="Sus scrofa"

<400> 5
Met Ala Ala Glu Glu Glu Glu Met Asp Ser Thr Asp Ala Cys Glu Arg 
1               5                   10                   15    
Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Thr 
            20                   25                  30        
Ser His Leu Lys Glu Ala Glu Glu Lys Ile Leu Lys Cys Val Pro Cys 
        35                   40                  45            
Ile Tyr Lys Lys Gly Pro Val Arg Ile Ser Asn Gly Asn Lys Ile Trp 
    50                   55                  60                
Thr Leu Lys Leu Ser His Asn Ile Ser Asn Lys Ile Pro Leu Val Leu 
65                   70                  75                  80
Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                   90                  95    
Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                  105                110        
Gly Arg Ser Ser Arg Pro Arg Phe Asp Thr Asp Ala Glu Glu Val Glu 
        115                  120                125            
Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                  135                140                
Asp Lys Val Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                  150                155                  160
Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Ser His Leu Ile Leu Val 
                165                  170                175    
Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Glu Arg 
            180                  185                190        
Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                  200                205            
Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                  215                220                
Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                  230                235                  240
Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                  250                255    
Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                  265                270        
Ala Lys Arg Pro Met Leu His Arg Ile Gly Lys Met Asn Pro Asp Ile 
        275                  280                285            
Pro Val Ser Val Ile Tyr Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                  295                300                
Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                  310                315                  320
Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Asp 
                325                  330                335    
Phe Asn Leu Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                  345                

<210> 6
<211> 1328
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1328
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 6
gcggctatgg cggcggagga ggaggaggtg gactctgccg acaccggaga gaggtcagga      60

tggctaactg gttggctccc cacatggtgc cctacgtcta tatcacacct taaagaagct     120

gaagagaaga tgttaaaatg tgtgccttgc acatacaaaa aagaacctgt tcgtatatct     180

aatggaaata aaatatggac actgaagttc tctcataata tttcaaataa gactccactt     240

gtccttctcc atggttttgg aggaggtctt gggctctggg cactgaattt tggagatctt     300

tgcaccaaca gacctgtcta tgcttttgac ctattgggtt ttggacgaag tagtagaccc     360

aggtttgaca gtgatgcaga agaagtggag aatcagtttg tggaatccat tgaagagtgg     420

agatgtgccc taggattgga caaaatgatc ttgcttgggc acaacctagg tggattcttg     480

gctgctgctt actcgctgaa gtacccatca agggttaatc atctcatttt agtggagcct     540

tggggtttcc ctgaacgacc agaccttgct gatcaagaca gaccaattcc agtttggatc     600

agagccttgg gagcagcatt gactcccttt aaccctttag ctggcctaag gattgcagga     660

ccctttggtt taagtctagt gcagcgttta aggcctgatt tcaaacgaaa gtattcttca     720

atgttcgaag acgatactgt gacagaatac atctaccact gtaatgtgca gactccaagt     780

ggtgagacag cttcaaagaa tatgactatt ccttatggat gggcaaaaag gccaatgctc     840

cagcgaattg gtaaaatgca ccctgacatt ccagtttcag tgatctttgg cgcccgatcc     900

tgcatagatg gcaattctgg caccagcatc cagtccttac gaccacattc atatgtgaag     960

acaatagcta ttcttggggc aggacattat gtatatgcag atcaaccaga agaattcaac    1020

cagaaagtaa aggagatctg cgacactgtg gactgaacac actgaagctc tgatgggaaa    1080

acctggtgac tgatatagtt gttcagcaat aattcatagt ctgtgatgaa gagtagtgaa    1140

tacaacacac aaccaggcag ccttcttgac tatactttgc acatgttttc tttaggaatt    1200

cactcacaca tttaaaccag ttagtgcctt ctagaagaat ggctttcctt tctcctacac    1260

aaaattgaaa tatacaagtc tctaaatata atacctttaa ataaaaggtt atttgtccct    1320

ctgaaaaa                                                             1328


<210> 7
<211> 3276
<212> DNA
<213> Pongo abelii

<220> 
<221> source
<222> 1..3276
<223> /mol_type="DNA"
      /organism="Pongo abelii"

<400> 7
ccagtcggcc tgtcagccgg ctttgagata agtccaggcg cttgcgcggc ggcggctatg       60

gcggcggagg aggaggaggt ggactctgcc gacaccggag agaggtcagg gtggctaact      120

ggttggcttc ccacatggtg ccctacgtct acatcacacc ttaaagaagc tgaagagaag      180

atgttaaaat gtgtgccttg cacatacaaa aaagaacctg ttcatatatc taatggaaat      240

aaaatatgga cactgaagtt ctctcataat atttcaaata agactccact tgtccttctc      300

catggttttg gaggaggtct tgggctctgg gcactgaatt ttggagatct ttgcaccaac      360

agacctgtct atgcttttga cctattgggt tttggacgaa gtagtagacc caggtttgac      420

agtgacgcag aagaagtgga gaatcagttt gtggaatcca ttgaagagtg gagatgtgcc      480

ctaggattgg acaaaatgat cttgcttggg cacaacctag gtggattctt ggctgctgct      540

tactcactga agtacccatc aagggttaat catctcattt tagtggagcc ttggggtttc      600

cctgaacgac cagaccttgc tgatcaagac agaccaattc cagtttggat cagagccttg      660

ggagcagcat tgactccctt taacccttta gctggcctaa ggattgcagg accctttggt      720

ttaagtctag tgcagcgttt aaggcctgat ttcaaacgaa agtattcttc aatgttcgaa      780

gacgatactg tgacagaata catctaccac tgtaatgtgc agactccaag tggtgagaca      840

gctttcaaga atatgactat tccttatgga tgggcaaaaa ggccaatgct ccagcgaatt      900

ggtaaaatgc accctgacat tccagtttca gtgatctttg gcgcccgatc ctgcatagat      960

ggcaattctg gcaccagcat ccagtcctta cgaccacatt catatgtgaa gacaatagct     1020

attcttgggg caggacatta tgtatatgca gatcaaccag aagaattcaa ccagaaagta     1080

aaggagatct gcgacactgt ggactgaaca cactgaagct ctgatgggaa aacctggtga     1140

ctgatacagt tgttcagcaa taattcatag tctgtgatga agagtaatga atacaacata     1200

gaaccaggca gccttcttga ctatactttt gcacatgttt tctttaggaa ttcgctcgca     1260

catttaaacc agttagtgcc ttctagaaga atggctttcc tttctcctac acaaaattga     1320

aatatacaag tctctaaatt taataccttt aaataaaagg ttatttgtcc ctctgatgta     1380

ctgaaaaact aatttttcag ctgaaaattt tttaatctaa ctttgctagt tatttttgta     1440

ttgcaatcta tattgccaat ttaggaagtg atttctgagt ctcttacact gtaaaggtgc     1500

actttatttt ctttgtcttc cccatcatgt atttattgtg tcttgataac tgatattaat     1560

ctaaattcaa tgtgttttta tgtaaaaatt tgtcagttgt ttagaatatt tcactttgtt     1620

tttgaaacgg agtgacaagg cagatttttg gttaaaggac gggagttgat cactatcatt     1680

actttttcta gtttacctct tttttatatt taaggctgct aagccatgtt cagcatttta     1740

aatgtggtct atcctgacat acacagtgta taacaaccta actccttgga acctcttatg     1800

tgtggtataa ttctacactt ccaaggaaca cgacttcagt gattcaggta ctgaaaagcc     1860

ttagctaaaa ggctgttgtt tccccctttc atactgttct tttccatgac ccaggatgca     1920

gcaaatgaaa cagatttctt ctcttaaggg gatattaaga ctgttacttc ctagtaagcc     1980

aagtaatacc atatttttat taacatctaa cttttgtaga tgggtgctaa aattgcatac     2040

gttttaacca ctaaaataga aaaacaagtg gtgctattat gtctcatggc accagaaatg     2100

agctagcact tgggtttgtt gttgttgttt attaagagta ttgtgttaat taaatcatta     2160

catacttgaa gttatattac aaaaattcta gaaggttggt tgaactattt ttttaggaac     2220

taccatcaag tgtagcattt tcttgcagtt ttaaaatgag gaaagcttct ttgaaactgt     2280

gaaatgctcc atgtggtaac tggctgctga gaaaaccctt caccaaaaaa ataaataaaa     2340

attgaatagg attgtcatca agaaggcatc tgtcgctaac gttgcttgtc taggagaaag     2400

gtagctatgt aaataaaaac agtgaactag agcaaatagt ggtttaatgg ttttgttatt     2460

gcatttttaa aatggttaat tagggaattt gtagttgtta ggaaatgtaa ggttgtgtca     2520

ctgttgatta actgccagaa agactgaatg ttctattttc aacatttctc ccctacaaaa     2580

gaatagacaa attatactga agcatgatat aaacatcttc ccaatgaaca atttgtctca     2640

cttgtcagat taactaggtt agtgcaggaa gcaacatgag cgccaagatg tgttgtctga     2700

tttctctacc ttaagaacaa taatagtctt tttagttagt attttggatg gccaggtttc     2760

aaacctgtat gtggtacaaa taatttgggt aatatttttg tatttttgtt ttacacactg     2820

tccaatctca attatccttt gctgggagaa tgacaggttt cacttatata ggaaggtttt     2880

tgcacaggaa atttggtccc agcccttgga aggaagaagt tccttggttt acttagtgaa     2940

tggagtttct ggccacagat gtgccaagtg attcaagaaa gatatacctg aatatcaagt     3000

gataatttat tttcctacag actgaatttg ctttatttga aagatgttgt aactcttttt     3060

aaagttagat tttaccctga ggtatagtat atgtaatttt gtgaagattg agctagaagg     3120

gaagttcaca atcctcacat ttaaaaaaat gtagtgtgtg ctaaatgttt tcttaaaaat     3180

ctattacagc atttgatctt tgttatgcac agtgtacttt tattttacag aataaatttt     3240

cctgtgatag tcacaacaaa aaaaaaaaaa aaaaaa                               3276


<210> 8
<211> 3148
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..3148
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 8
gccgctggga cgccgagcct gcggtggcgc ggccgcgccc tcggatcgtc ccagcgggcg      60

gacgacgcat gcgcgggcgg tgcggtctta agggcggccg cggcccgggg ccgcccagtc     120

ggcctgtcag ccggcttcga ggtgtgtccc tgcgcttgcg cggcggcggt gatgaaagcg     180

atggcggcgg aggaggaggt ggactcggca gacgccggtg gagggtcagg atggctgaca     240

gggtggcttc ctacctggtg tcccacatct acatcacacc ttaaagaagc tgaagagaaa     300

atgttaaaat gtgtcccctg cacttacaag aaagagcctg tgcgcatatc caatggaaac     360

agaatatgga cgctgatgtt ctctcacaac atttctagta agacgccact tgtcctcctt     420

catggttttg gaggaggtct tggactttgg gccctgaatt ttgaagatct aagcaccgat     480

aggcctgtct atgcctttga cctattgggc ttcggaagaa gtagtagacc taggtttgac     540

agtgatgcgg aagaagtgga gaatcagttt gtggaatcca ttgaagagtg gagatgtgcc     600

ctcaggttgg acaaaatgat cttgcttgga cacaacctgg gagggttctt ggctgccgct     660

tactcactga agtacccatc aagggttagt cacctcattt tagtagagcc atggggtttt     720

cctgagcgac cagatcttgc tgatcaagag agaccaattc cagtttggat cagggcccta     780

ggggcagcat tgactccctt taaccccttg gctggcctca ggattgcagg accttttggg     840

ttaagtctag tgcagcgttt gaggcctgat ttcaagcgga agtactcctc tatgtttgaa     900

gatgacacgg tgacagagta catctaccac tgtaatgtac aaaccccaag tggtgagaca     960

gctttcaaaa acatgacgat tccttatggg tgggccaaac ggccaatgct tcagcggata    1020

ggtggcttgc atcctgacat tccagtttca gtgatctttg gagcccgatc ctgcatagat    1080

ggcaactctg gaaccagcat ccagtcactg cgaccgaagt cctacgtgaa gacaattgcc    1140

atcctcgggg cggggcatta tgtgtatgca gatcagccag aagaattcaa ccagaaagtc    1200

aaggagatct gccacacagt agactgagca cacagaacca tgcagcaccc gtgacgggtg    1260

ccgttcatga gcaatcccca cagcccgagg acccccgcag tctcctggac tggactctgc    1320

agctttccac atttaaacca accagtgcct tctagaagaa tggctttcct ttctcctaca    1380

cagaattaaa atataggaga gtctcccaat ttaataatcg ccttaaataa aggttgtcct    1440

tctgatgtac tgaaaaattg tgatttttca gctgagactt ttctcaattt cacctaactg    1500

cttgttaggt gtttggtgtt gcagtccgta tgccagtgta cctagtccat atgccagtgt    1560

acctagtcca tatgccagtg tacctagcga cttctgggcc tgtggtgtta ggtgttggga    1620

agctgcactt tattttcctt gcatgtattt actgtctcta acaactaaca tagttaaccc    1680

aagtattttt atgtaaaaag atttcaattt agaatacttc atttttgaga tggagtttag    1740

aatatttcat tttgaaatgg aacgaaaggg ttaggttttg atgtaaaaga caggagtcaa    1800

tcactagcgt taactttcct tgttttcctg ttttatgatc aaggccgtgt ttcagcattt    1860

taaatgtgtt ccatggtgac atagtgctta cagcaacgca gttcctgggg cccttctgtg    1920

tgtaatctac agggttctat gagaacatat gcatagactc agccattcaa gtgctgagta    1980

gcccgaacct gaaacctgtc ccctttcctt ccagtattcc caggacccag gatctaggtc    2040

ccctcacttg cagggatgtt aacactgttg cctatcggga aaccaagtcc cactgtgttc    2100

tcatgagcaa ccagcttaca tggtgcttaa actggattgc attttaccac taacatttaa    2160

aactatgtgg tgctgttacg tctcatggcg ccagaaatga gatagaactt gtggttattt    2220

ttattgaata ttatgttaat ctaaccactt atatacttga agtaaaatta tgaaaaaaat    2280

ctattatgtt gtttgaactg tttggcagaa accaccattg gatttataac tttctgacag    2340

tgttaaagtg agagacaatt tgaaactatg aaaaagctcc atggaatagc tggatgctga    2400

gaaagccttc tgtctagaga acagagaaca aagagcattg ttaccaacat tgtttgtcca    2460

ggagaaaagc agattacaca aataaaacct cgacctcaca aatcacgact cgatgacttg    2520

agctattaca tttttagtga ctagtcagga aatttttttg aaaatataaa attatatcac    2580

atgtaattaa ctgccagcaa gattagctcc atactttagg agaccgtgaa aatcatattg    2640

aagcgggaca aagcagcctc ccagcgaccc tttatctgac tcatttaacg cattaggtta    2700

gtgcaaggag ccaccgtgag accaaaagtg cttgttctca ccaccttgag aataaaaata    2760

gcctttttcc ccctttatag ttagtgttgt gggtggccag atccacactt gagagtggta    2820

gaacatttgt gcaggactct tacttggcag tcaccagcct cagtcttttg ttcaccaaag    2880

aaaaaaaatt ctgcacaaga aaccggtctg cccaaagaaa ctgacttccc cactgagctg    2940

ctttgcttta ctggaaacct gtgaagcttc ctaaacatta aaatttccat ggtgtgtgca    3000

gtgattgttg taaaggttga agtagtaaag tttataatct gcaaattctt gagaacagtg    3060

gttgctaaac atctttcttg taaacgatct cttaactatc attggtcttt gctaagttat    3120

tttacagaat aaactcgaca gtgctagc                                       3148


<210> 9
<211> 1108
<212> DNA
<213> Rattus norvegicus

<220> 
<221> source
<222> 1..1108
<223> /mol_type="DNA"
      /organism="Rattus norvegicus"

<400> 9
cggcttcgag gtgccttcct gcgcttgcgc ggcggcagtg atgaaagcga tggcggcgga      60

ggaggaggtg gactcggcag acgccggtgg agggtcagga tggctgacag ggtggcttcc     120

tacctggtgt cccacgtcta catcacacct taaagaagct gaagagaaaa tgctaaaatg     180

tgtcccctgc acttacaaga aagaacctgt gcgcatatcc aatggaaaca gcatatggac     240

actgatgttc tcgcacaaca tgtctagtaa gacaccactt gtcctcctgc atggttttgg     300

aggaggtctt ggactttggg ccctgaattt tgaagatcta agcactgata ggcctgtcta     360

tgcctttgac ctattgggct ttggaagaag tagtagacct aggtttgaca gtgacgcgga     420

agaagtggag aatcagtttg tggaatccat tgaagagtgg agatgtgccc tcaggttgga     480

caaaatgatc ttgcttggac acaacctggg agggttcttg gctgctgcct actcactgaa     540

gtacccgtca agggtcagtc acctcatttt agtagaacca tggggttttc ctgagcgacc     600

agatcttgct gatcaagaga gaccaattcc agtttggatc agagccttag gggcagcatt     660

gactcccttt aaccccttgg ctggcctcag gattgcagga ccttttgggt tgagtctagt     720

gcagcgcctg aggccggact tcaagcggaa gtactcctct atgtttgaag atgacacggt     780

gacagagtac atctaccact gtaatgtaca aaccccaagt ggtgagacag ctttcaaaaa     840

catgacgatt ccttacgggt gggccaagcg gcccatgctc cagcgcatag gtggcttgca     900

ccctgacatt ccagtttcag tcatcttcgg cgcccggtcc tgcatagatg gcaactctgg     960

caccagcatc cagtcactgc gacccaagtc atacgtgaag acaattgcta tcctcggggc    1020

agggcattat gtgtatgcag accagccaga ggagttcaac cagaaagtca aggagatctg    1080

ccacacagta gactgagcac acggaacc                                       1108


<210> 10
<211> 1353
<212> DNA
<213> Sus scrofa

<220> 
<221> source
<222> 1..1353
<223> /mol_type="DNA"
      /organism="Sus scrofa"

<400> 10
attgcgcgcg gctatggcag cagaggagga ggagatggac tccacggatg cctgtgagag      60

gtctggatgg ctaactggtt ggcttcccac atggtgccct acatcgacgt cacaccttaa     120

agaagctgaa gagaaaattt taaaatgtgt cccctgcata tacaaaaaag gacctgttcg     180

tatatctaat ggaaataaaa tatggacact gaagctctct cataatattt caaataagat     240

tccccttgtc ctccttcatg gttttggagg aggtctcgga ctttgggcac tgaattttgg     300

agatctttgc accaatagac ccgtctatgc ttttgacctg ctgggctttg gacgaagtag     360

tagacccaga tttgacactg atgcagaaga agtggagaat cagtttgtgg aatccattga     420

agagtggaga tgtgccttag gattggacaa agtgatcttg ctgggacaca acctgggtgg     480

gttcctagct gctgcttact cactgaagta cccctcaagg gttagtcatc tcattttagt     540

tgaaccttgg ggttttcctg agcgaccaga ccttgctgat caagagagac caattccagt     600

ttggatcaga gccttgggag cggcattgac tcccttcaac cctttagctg gtctcaggat     660

tgcaggaccc tttggtttaa gtctagtaca gcgtttaagg cctgatttca aacggaagta     720

ttcttcaatg tttgaagatg atactgtgac agaatatatc taccactgta atgttcagac     780

tcccagtggt gagactgcat tcaaaaatat gactatccct tatggatggg caaaaaggcc     840

aatgctccat cggattggta aaatgaaccc tgacattcca gtttcggtga tctacggagc     900

ccgatcctgc atagatggca attctggcac cagcatccag tcattacgac cacattcata     960

cgtgaagaca atagccattc ttggagcagg acattatgtg tatgcagatc aaccagaaga    1020

cttcaaccta aaagtaaagg agatctgtga cactgtggac tgagtgcaat gcagatgaca    1080

taggaagccc gatggctgat ccagttcctc agcaataatc cccagtctgc aatgaagagt    1140

aaggaatcca gcatgagaac caggcactct tcctgcctgt actttgcaca tgttttcttt    1200

atgaagctac tcacacattt aaaccagttg gtgccttcta gacgattggc tttcctttct    1260

cctacacaaa atcaaaatat acaagaccct ccaaatctaa tagctttaat aaaaggttat    1320

ttgtccctct gctgtaaaaa aaaaaaaaaa aaa                                 1353


<210> 11
<211> 1084
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1084
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 11
Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                   15    
Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                   25                  30        
Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                   40                  45            
Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                   55                  60                
Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                   70                  75                  80
Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                   90                  95    
His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                  105                110        
Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                  120                125            
Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                  135                140                
Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                  150                155                  160
Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                  170                175    
Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                  185                190        
His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                  200                205            
Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                  215                220                
Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                  230                235                  240
Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                  250                255    
Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                  265                270        
Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                  280                285            
Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                  295                300                
Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                  310                315                  320
Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                  330                335    
Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                  345                350        
Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                  360                365            
Gly Gln Gln Asp Thr Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                  375                380                
Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                  390                395                  400
Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                  410                415    
Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly 
            420                  425                430        
Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg 
        435                  440                445            
Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg 
    450                  455                460                
Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu 
465                  470                475                  480
Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln 
                485                  490                495    
Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser 
            500                  505                510        
Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu 
        515                  520                525            
Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu 
    530                  535                540                
Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln 
545                  550                555                  560
Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val 
                565                  570                575    
Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln 
            580                  585                590        
Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr 
        595                  600                605            
Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His 
    610                  615                620                
Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro 
625                  630                635                  640
Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu 
                645                  650                655    
Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser 
            660                  665                670        
Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg 
        675                  680                685            
Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg 
    690                  695                700                
Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr 
705                  710                715                  720
Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys 
                725                  730                735    
Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly 
            740                  745                750        
Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala 
        755                  760                765            
Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys 
    770                  775                780                
Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro 
785                  790                795                  800
Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn 
                805                  810                815    
Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser 
            820                  825                830        
Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln 
        835                  840                845            
Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg 
    850                  855                860                
Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val 
865                  870                875                  880
Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly 
                885                  890                895    
Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg 
            900                  905                910        
Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu 
        915                  920                925            
Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly 
    930                  935                940                
Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu 
945                  950                955                  960
Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His 
                965                  970                975    
Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu 
            980                  985                990        
Leu Gly Asn Glu Leu Asp Pro Leu Pro Glu Lys Val Leu Gln Gln Arg 
        995                  1000                1005            
Pro Asn Ala Asn Ala Val Arg Ser Met Glu Lys Val Met Glu Ile His 
    1010                1015                1020                
Ser Lys Tyr Trp Arg Cys Leu Gln Arg Thr Thr Ser Thr Ala Gly Arg 
1025                1030                1035                1040
Ser Leu Ile Glu Ala Gln Thr Cys Glu Asn Glu Glu Ala Glu Thr Val 
                1045                1050                1055    
Thr Ala Met Ala Ser Leu Ser Val Gly Val Lys Pro Ala Glu Lys Arg 
            1060                1065                1070        
Pro Asp Glu Glu Pro Met Glu Glu Glu Pro Pro Leu 
        1075                1080                

<210> 12
<211> 1081
<212> PRT
<213> Mus musculus

<220> 
<221> SOURCE
<222> 1..1081
<223> /mol_type="protein"
      /organism="Mus musculus"

<400> 12
Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                   15    
Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                   25                  30        
Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Thr Ala Val Pro 
        35                   40                  45            
Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Leu Glu Pro Ala 
    50                   55                  60                
Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln Lys 
65                   70                  75                  80
Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln His 
                85                   90                  95    
Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile Lys 
            100                  105                110        
Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu 
        115                  120                125            
His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys 
    130                  135                140                
Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly 
145                  150                155                  160
Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln Glu 
                165                  170                175    
Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn His 
            180                  185                190        
Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His Ser 
        195                  200                205            
Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Ala Ser Tyr 
    210                  215                220                
Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro Leu 
225                  230                235                  240
Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu Lys 
                245                  250                255    
Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp 
            260                  265                270        
Gly Pro Val Ala Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr Asp 
        275                  280                285            
Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn Ser 
    290                  295                300                
Ser Ser Gly Asn Val Ser Thr Glu Asn Gly Ile Ala Pro Thr Val Pro 
305                  310                315                  320
Ser Ala Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Thr Arg Glu 
                325                  330                335    
Gly Ser Val Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro Asn 
            340                  345                350        
Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ala Ala Gly Ala Ala Gly 
        355                  360                365            
Gln Gln Asp Ala Glu Arg Leu Ala Leu Pro Ala Leu Gln Gln Arg Ile 
    370                  375                380                
Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser Pro Leu 
385                  390                395                  400
Glu Arg Asp Gly Ala Ala Ala His Asn Pro Leu Leu Gln His Met Val 
                405                  410                415    
Leu Leu Glu Gln Pro Pro Thr Gln Thr Pro Leu Val Thr Gly Leu Gly 
            420                  425                430        
Ala Leu Pro Leu His Ser Gln Ser Leu Val Gly Ala Asp Arg Val Ser 
        435                  440                445            
Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg Thr Gln 
    450                  455                460                
Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu Val Ile 
465                  470                475                  480
Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln Phe Gln 
                485                  490                495    
Gln Gln Gln Leu His Leu Ser Lys Ile Ile Ser Lys Pro Ser Glu Pro 
            500                  505                510        
Pro Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu Leu Arg 
        515                  520                525            
Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu Pro Gly 
    530                  535                540                
Gln Lys Glu Pro Ser Leu Ala Gly Val Gln Val Lys Gln Glu Pro Ile 
545                  550                555                  560
Glu Ser Glu Glu Glu Glu Ala Glu Ala Thr Arg Glu Thr Glu Pro Gly 
                565                  570                575    
Gln Arg Pro Ala Thr Glu Gln Glu Leu Leu Phe Arg Gln Gln Ala Leu 
            580                  585                590        
Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr Gln Ala Ser 
        595                  600                605            
Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Ser His Arg Pro Leu 
    610                  615                620                
Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro Met Ser Val 
625                  630                635                  640
Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu Val Tyr Asp 
                645                  650                655    
Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Asn Thr Asn Ser His 
            660                  665                670        
Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu 
        675                  680                685            
Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg Lys Ala Thr 
    690                  695                700                
Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr Leu Leu Tyr 
705                  710                715                  720
Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu 
                725                  730                735    
Gly Ser Leu Thr Ser Val Phe Val Arg Leu Pro Cys Gly Gly Val Gly 
            740                  745                750        
Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ser Gly Ala Ala 
        755                  760                765            
Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys Val Ala Thr 
    770                  775                780                
Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
785                  790                795                  800
Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn Ser Val Ala 
                805                  810                815    
Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Asn Val Ser Lys Ile Leu 
            820                  825                830        
Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Ala Phe 
        835                  840                845            
Tyr Asn Asp Pro Asn Val Leu Tyr Met Ser Leu His Arg Tyr Asp Asp 
    850                  855                860                
Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val Gly Thr Gly 
865                  870                875                  880
Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly Gly Leu Glu 
                885                  890                895    
Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg Thr Val Val 
            900                  905                910        
Met Pro Ile Ala Asn Glu Phe Ala Pro Asp Val Val Leu Val Ser Ser 
        915                  920                925            
Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly Gly Tyr Asn 
    930                  935                940                
Leu Ser Ala Lys Cys Phe Gly Tyr Leu Thr Lys Gln Leu Met Gly Leu 
945                  950                955                  960
Ala Gly Gly Arg Leu Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
                965                  970                975    
Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu Leu Gly Asn 
            980                  985                990        
Glu Leu Glu Pro Leu Pro Glu Lys Val Leu His Gln Arg Pro Asn Ala 
        995                  1000                1005            
Asn Ala Val His Ser Met Glu Lys Val Met Asp Ile His Ser Lys Tyr 
    1010                1015                1020                
Trp Arg Cys Leu Gln Arg Leu Ser Ser Thr Val Gly His Ser Leu Ile 
1025                1030                1035                1040
Glu Ala Gln Lys Cys Glu Lys Glu Glu Ala Glu Thr Val Thr Ala Met 
                1045                1050                1055    
Ala Ser Leu Ser Val Gly Val Lys Pro Ala Glu Lys Arg Ser Glu Glu 
            1060                1065                1070        
Glu Pro Met Glu Glu Glu Pro Pro Leu 
        1075                1080    

<210> 13
<211> 201
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..201
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 13
Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                   15    
Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                   25                  30        
Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                   40                  45            
Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                   55                  60                
Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                   70                  75                  80
Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                   90                  95    
His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                  105                110        
Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                  120                125            
Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                  135                140                
Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                  150                155                  160
Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                  170                175    
Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                  185                190        
His Cys Ile Ser Ser Asp Pro Arg Tyr 
        195                  200    

<210> 14
<211> 201
<212> PRT
<213> Mus musculus

<220> 
<221> SOURCE
<222> 1..201
<223> /mol_type="protein"
      /organism="Mus musculus"

<400> 14
Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                   15    
Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                   25                  30        
Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Thr Ala Val Pro 
        35                   40                  45            
Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Leu Glu Pro Ala 
    50                   55                  60                
Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln Lys 
65                   70                  75                  80
Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln His 
                85                   90                  95    
Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile Lys 
            100                  105                110        
Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu Glu 
        115                  120                125            
His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu Lys 
    130                  135                140                
Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys Gly 
145                  150                155                  160
Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln Glu 
                165                  170                175    
Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn His 
            180                  185                190        
Cys Ile Ser Ser Asp Pro Arg Tyr Trp 
        195                  200    

<210> 15
<211> 3255
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3255
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 15
atgagctccc aaagccatcc agatggactt tctggccgag accagccagt ggagctgctg       60

aatcctgccc gcgtgaacca catgcccagc acggtggatg tggccacggc gctgcctctg      120

caagtggccc cctcggcagt gcccatggac ctgcgcctgg accaccagtt ctcactgcct      180

gtggcagagc cggccctgcg ggagcagcag ctgcagcagg agctcctggc gctcaagcag      240

aagcagcaga tccagaggca gatcctcatc gctgagttcc agaggcagca cgagcagctc      300

tcccggcagc acgaggcgca gctccacgag cacatcaagc aacaacagga gatgctggcc      360

atgaagcacc agcaggagct gctggaacac cagcggaagc tggagaggca ccgccaggag      420

caggagctgg agaagcagca ccgggagcag aagctgcagc agctcaagaa caaggagaag      480

ggcaaagaga gtgccgtggc cagcacagaa gtgaagatga agttacaaga atttgtcctc      540

aataaaaaga aggcgctggc ccaccggaat ctgaaccact gcatttccag cgaccctcgc      600

tactggtacg ggaaaacgca gcacagttcc cttgaccaga gttctccacc ccagagcgga      660

gtgtcgacct cctataacca cccggtcctg ggaatgtacg acgccaaaga tgacttccct      720

cttaggaaaa cagcttctga accgaatctg aaattacggt ccaggctaaa gcagaaagtg      780

gccgaaagac ggagcagccc cctgttacgc aggaaagacg ggccagtggt cactgctcta      840

aaaaagcgtc cgttggatgt cacagactcc gcgtgcagca gcgccccagg ctccggaccc      900

agctcaccca acaacagctc cgggagcgtc agcgcggaga acggtatcgc gcccgccgtc      960

cccagcatcc cggcggagac gagtttggcg cacagacttg tggcacgaga aggctcggcc     1020

gctccacttc ccctctacac atcgccatcc ttgcccaaca tcacgctggg cctgcctgcc     1080

accggcccct ctgcgggcac ggcgggccag caggacaccg agagactcac ccttcccgcc     1140

ctccagcaga ggctctccct tttccccggc acccacctca ctccctacct gagcacctcg     1200

cccttggagc gggacggagg ggcagcgcac agccctcttc tgcagcacat ggtcttactg     1260

gagcagccac cggcacaagc acccctcgtc acaggcctgg gagcactgcc cctccacgca     1320

cagtccttgg ttggtgcaga ccgggtgtcc ccctccatcc acaagctgcg gcagcaccgc     1380

ccactggggc ggacccagtc ggccccgctg ccccagaacg cccaggctct gcagcacctg     1440

gtcatccagc agcagcatca gcagtttctg gagaaacaca agcagcagtt ccagcagcag     1500

caactgcaga tgaacaagat catccccaag ccaagcgagc cagcccggca gccggagagc     1560

cacccggagg agacggagga ggagctccgt gagcaccagg ctctgctgga cgagccctac     1620

ctggaccggc tgccggggca gaaggaggcg cacgcacagg ccggcgtgca ggtgaagcag     1680

gagcccattg agagcgatga ggaagaggca gagcccccac gggaggtgga gccgggccag     1740

cgccagccca gtgagcagga gctgctcttc agacagcaag ccctcctgct ggagcagcag     1800

cggatccacc agctgaggaa ctaccaggcg tccatggagg ccgccggcat ccccgtgtcc     1860

ttcggcggcc acaggcctct gtcccgggcg cagtcctcac ccgcgtctgc caccttcccc     1920

gtgtctgtgc aggagccccc caccaagccg aggttcacga caggcctcgt gtatgacacg     1980

ctgatgctga agcaccagtg cacctgcggg agtagcagca gccaccccga gcacgccggg     2040

aggatccaga gcatctggtc ccgcctgcag gagacgggcc tccggggcaa atgcgagtgc     2100

atccgcggac gcaaggccac cctggaggag ctacagacgg tgcactcgga agcccacacc     2160

ctcctgtatg gcacgaaccc cctcaaccgg cagaaactgg acagtaagaa acttctaggc     2220

tcgctcgcct ccgtgttcgt ccggctccct tgcggtggtg ttggggtgga cagtgacacc     2280

atatggaacg aggtgcactc ggcgggggca gcccgcctgg ctgtgggctg cgtggtagag     2340

ctggtcttca aggtggccac aggggagctg aagaatggct ttgctgtggt ccgcccccct     2400

ggacaccatg cggaggagag cacgcccatg ggcttttgct acttcaactc cgtggccgtg     2460

gcagccaagc ttctgcagca gaggttgagc gtgagcaaga tcctcatcgt ggactgggac     2520

gtgcaccatg gaaacgggac ccagcaggct ttctacagcg accctagcgt cctgtacatg     2580

tccctccacc gctacgacga tgggaacttc ttcccaggca gcggggctcc tgatgaggtg     2640

ggcacagggc ccggcgtggg tttcaacgtc aacatggctt tcaccggcgg cctggacccc     2700

cccatgggag acgctgagta cttggcggcc ttcagaacgg tggtcatgcc gatcgccagc     2760

gagtttgccc cggatgtggt gctggtgtca tcaggcttcg atgccgtgga gggccacccc     2820

acccctcttg ggggctacaa cctctccgcc agatgcttcg ggtacctgac gaagcagctg     2880

atgggcctgg ctggcggccg gattgtcctg gccctcgagg gaggccacga cctgaccgcc     2940

atttgcgacg cctcggaagc atgtgtttct gccttgctgg gaaacgagct tgatcctctc     3000

ccagaaaagg ttttacagca aagacccaat gcaaacgctg tccgttccat ggagaaagtc     3060

atggagatcc acagcaagta ctggcgctgc ctgcagcgca caacctccac agcggggcgt     3120

tctctgatcg aggctcagac ttgcgagaac gaagaagccg agacggtcac cgccatggcc     3180

tcgctgtccg tgggcgtgaa gcccgccgaa aagagaccag atgaggagcc catggaagag     3240

gagccgcccc tgtag                                                      3255


<210> 16
<211> 3246
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..3246
<223> /mol_type="DNA"
      /organism="Mus musculus"

<400> 16
atgagctccc aaagccatcc agatggactt tctggccgag accagcctgt ggagctgctg       60

aatcctgccc gtgtgaacca catgcccagc acggtggacg tggctacagc gctgcctctg      120

caagtggccc ctacagcagt acccatggac ctgcgcttgg accaccagtt ctcactgccc      180

ttggaacctg cattgcggga gcagcaactg cagcaggaac tcctagcact gaaacagaag      240

cagcagatcc agcggcagat actcattgca gagttccagc gtcaacatga gcagttgtcc      300

cgacagcatg aggcacagtt gcatgaacat atcaagcagc agcaggagat gctggccatg      360

aagcaccagc aggagctgct ggagcaccag cggaaactgg agcggcaccg gcaagagcag      420

gagctggaga agcagcaccg tgagcagaag ctgcagcagc tcaagaacaa ggagaagggc      480

aaagagagtg ctgtggcgag cacagaggtg aagatgaagc tgcaggagtt tgttctcaac      540

aagaagaagg ctctagccca ccggaacctg aaccactgca tttccagcga tccccgctac      600

tggtatggga agacacagca cagctccctt gaccagagct ctccacccca gagtggggtg      660

tcagcctcct acaaccaccc cgtcttggga atgtacgacg ccaaagatga cttccctctt      720

aggaaaacag cttctgaacc taacctgaaa ttacgctcaa ggcttaagca gaaagtagct      780

gagagacgga gcagccccct gttgcgcagg aaagatggcc ctgtggccac tgctctaaaa      840

aagcgacccc tggatgttac agactccgca tgcagcagcg cccctggctc cggtcccagc      900

tctccaaata gcagctctgg caacgtcagc actgagaatg gcatcgcacc cactgtgccc      960

agcgctccag ctgagacgag cttggcacac agacttgtga ctcgagaagg ctcagtcgcc     1020

ccacttcctc tctacacgtc accatcctta cccaacatca ccttgggact tcctgccact     1080

ggccctgccg ctggtgcggc aggtcagcag gatgctgaga ggcttgctct cccagctctc     1140

cagcagcgga tcttgttccc tgggacccac ctcaccccgt acctgagcac ctcgcccctg     1200

gagagggacg gtgcagcagc tcacaacccc ctcctgcagc acatggtcct gctggagcag     1260

ccacccaccc agacacccct tgtcacaggc ctgggggcgc tgcccctcca ctcacagtcc     1320

ctggttggtg cggacagggt gtccccatcc attcacaagc tgcggcagca ccgccctctg     1380

gggcgcacgc agtcagcacc cctgccgcag aacgcacagg ccctgcagca cctggtgatc     1440

cagcagcagc accagcagtt cctggagaag cacaagcaac agttccagca gcagcagctg     1500

cacctcagca agataatctc caaacctagt gagccacctc ggcagcctga gagccaccca     1560

gaggagacag aggaggagct ccgtgagcac caggccttgc tggatgagcc ctacctagat     1620

cggctacctg ggcagaagga gccctccctg gctggtgtgc aggtgaagca ggagcccatt     1680

gagagtgagg aggaagaagc ggaggccact cgagagacag agcccggcca gcgcccagcc     1740

actgagcagg agctgctctt cagacagcaa gccctcctac tggagcagca gaggatccac     1800

cagttaagaa actaccaggc atctatggag gctgctggca tccctgtgtc atttggcagc     1860

cacagacctc tgtctcgggc acagtcctcc ccagcatctg ccaccttccc catgtcagtc     1920

caggagcccc ccaccaagcc aaggttcacc acaggtcttg tgtatgacac actgatgttg     1980

aagcatcagt gcacctgtgg gaacaccaac agccacccgg agcatgctgg gaggatccag     2040

agcatctggt cccgcctgca ggagactgga ctccgtggca agtgtgagtg catccgtgga     2100

cgcaaggcca cattggagga gctgcagaca gtgcactcgg aggcccacac actcctctac     2160

ggcacaaatc ctctcaacag acagaaactg gacagtaaga aacttctagg ctcgctgacc     2220

tcagtgttcg tcaggcttcc ttgtggtggt gttggggtgg atagcgacac catatggaat     2280

gaggtgcact cgtctggggc agcccgcctg gctgtaggct gtgtagtgga gctggtcttc     2340

aaggtggcca cgggagagct aaagaatggc tttgctgtgg ttcgtccccc aggacaccat     2400

gccgaggaga gcacacccat gggtttctgc tactttaact ccgtggcagt tgcagccaaa     2460

cttctccagc agaggctgaa tgtgagcaag atcctcattg tagactggga tgtacatcat     2520

gggaatggga cccagcaggc cttctacaat gaccccaatg ttctctacat gtccctgcac     2580

cgctatgacg atgggaactt cttcccagga agtggagcac cagatgaggt gggcacaggg     2640

ccaggcgtgg gtttcaatgt caacatggct ttcacgggtg gcctcgaacc ccccatggga     2700

gacgctgagt acttggcagc cttcagaacg gtggttatgc ctatcgcaaa tgagtttgcc     2760

ccagatgtgg tactggtgtc atcgggcttc gatgctgtgg agggccaccc cacacctctt     2820

ggagggtaca atctctctgc caaatgtttt gggtacttga caaaacagct gatgggctta     2880

gctggtggcc ggcttgtgct ggcccttgag ggaggccatg acctgacagc catctgtgat     2940

gcttctgaag cctgcgtgtc tgctctgctg ggaaacgagc ttgagcctct gccagaaaag     3000

gttctacatc agagacccaa tgccaatgct gtccactcca tggagaaagt gatggacatc     3060

cacagcaagt actggcgctg cctgcagcgt ctgtcctcca cggtggggca ctctctgatt     3120

gaggcgcaaa agtgtgagaa ggaagaagct gagacagtca ccgccatggc ctcgctgtct     3180

gtaggcgtca aacctgctga gaagagatct gaggaggagc ccatggagga ggaaccacca     3240

ctgtag                                                                3246


<210> 17
<211> 603
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..603
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 17
atgagctccc aaagccatcc agatggactt tctggccgag accagccagt ggagctgctg      60

aatcctgccc gcgtgaacca catgcccagc acggtggatg tggccacggc gctgcctctg     120

caagtggccc cctcggcagt gcccatggac ctgcgcctgg accaccagtt ctcactgcct     180

gtggcagagc cggccctgcg ggagcagcag ctgcagcagg agctcctggc gctcaagcag     240

aagcagcaga tccagaggca gatcctcatc gctgagttcc agaggcagca cgagcagctc     300

tcccggcagc acgaggcgca gctccacgag cacatcaagc aacaacagga gatgctggcc     360

atgaagcacc agcaggagct gctggaacac cagcggaagc tggagaggca ccgccaggag     420

caggagctgg agaagcagca ccgggagcag aagctgcagc agctcaagaa caaggagaag     480

ggcaaagaga gtgccgtggc cagcacagaa gtgaagatga agttacaaga atttgtcctc     540

aataaaaaga aggcgctggc ccaccggaat ctgaaccact gcatttccag cgaccctcgc     600

tac                                                                   603


<210> 18
<211> 4959
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..4959
<223> /mol_type="DNA"
      /note="Vector encoding human HDAC4-NT"
      /organism="Artificial Sequence"

<400> 18
gggggggggg gggggggggg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg       60

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc      120

gcgcagagag ggagtggcca actccatcac taggggttcc tagatctgaa ttcggtaccg      180

cggtggcggc cgcttcgagc tcgcccgaca ttgattattg actagttatt aatagtaatc      240

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      300

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      360

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      420

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      480

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      540

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg      600

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc      660

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg      720

taacaactcc gccccatgcg gccgctctag gacccagagc acagagcatc gttcccaggc      780

caggccccag ccactgtctc tttaaccttg aaggcatttt tgggtctcac gtgtccaccc      840

aggcgggtgt cggactttga acggctctta cttcagaaga acggcatggg gtgggggggc      900

ttaggtggcc tctgcctcac ctacaactgc caaaagtggt catggggtta tttttaaccc      960

cagggaagag gtatttattg ttccacagca ggggccggcc agcaggctcc ttgaattctg     1020

cagtcgacgg taccgcggcc gcccccaatt cgagctcgcc cggggatccg ccaccatgag     1080

ctcccaaagc catccagatg gactttctgg ccgagaccag ccagtggagc tgctgaatcc     1140

tgcccgcgtg aaccacatgc ccagcacggt ggatgtggcc acggcgctgc ctctgcaagt     1200

ggccccctcg gcagtgccca tggacctgcg cctggaccac cagttctcac tgcctgtggc     1260

agagccggcc ctgcgggagc agcagctgca gcaggagctc ctggcgctca agcagaagca     1320

gcagatccag aggcagatcc tcatcgctga gttccagagg cagcacgagc agctctcccg     1380

gcagcacgag gcgcagctcc acgagcacat caagcaacaa caggagatgc tggccatgaa     1440

gcaccagcag gagctgctgg aacaccagcg gaagctggag aggcaccgcc aggagcagga     1500

gctggagaag cagcaccggg agcagaagct gcagcagctc aagaacaagg agaagggcaa     1560

agagagtgcc gtggccagca cagaagtgaa gatgaagtta caagaatttg tcctcaataa     1620

aaagaaggcg ctggcccacc ggaatctgaa ccactgcatt tccagcgacc ctcgctacta     1680

gtctagagtc ggggcggccg gccgcttcga gcagacatga taagatacat tgatgagttt     1740

ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct     1800

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt     1860

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc     1920

tacaaatgtg gtaaaatcga taactgggga gagatctagg aacccctagt gatggagttg     1980

gccactccct ctctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     2040

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     2100

cccccccccc cccccccctg cagcccagct gcattaatga atcggccaac gcgcggggag     2160

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     2220

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     2280

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     2340

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     2400

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     2460

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     2520

gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct gtaggtatct     2580

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     2640

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     2700

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     2760

tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat     2820

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     2880

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     2940

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     3000

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     3060

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     3120

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     3180

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     3240

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     3300

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     3360

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     3420

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     3480

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     3540

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     3600

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     3660

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     3720

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     3780

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     3840

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     3900

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     3960

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     4020

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     4080

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     4140

gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga     4200

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     4260

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     4320

ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga     4380

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt     4440

ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa     4500

atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca     4560

gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc     4620

gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg     4680

aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg     4740

ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg     4800

gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg     4860

ccgctacagg gcgcgtcgcg ccattcgcca ttcaggctac gcaactgttg ggaagggcga     4920

tcggtgcggg cctcttcgct attacgccag ctggctgca                            4959


<210> 19
<211> 5932
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..5932
<223> /mol_type="DNA"
      /note="Vector for cardiomyocyte-specific expression of transgenes
      "
      /organism="Artificial Sequence"

<400> 19
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtctc      120

agtccattag gagccagtag cctggaagat gtctttaccc ccagcatcag ttcaagtgga      180

gcagcacata actcttgccc tctgccttcc aagattctgg tgctgagact tatggagtgt      240

cttggaggtt gccttctgcc ccccaaccct gctcccagct ggccctccca ggcctgggtt      300

gctggcctct gctttatcag gattctcaag agggacagct ggtttatgtt gcatgactgt      360

tccctgcata tctgctctgg ttttaaatag cttatctgag cagctggagg accacatggg      420

cttatatggc gtggggtaca tgttcctgta gccttgtccc tggcacctgc caaaatagca      480

gccaacaccc cccaccccca ccgccatccc cctgccccac ccgtcccctg tcgcacattc      540

ctccctccgc agggctggct caccaggccc cagcccacat gcctgcttaa agccctctcc      600

atcctctgcc tcacccagtc ccaagcttta ttgcggtagt ttatcacagt taaattgcta      660

acgcagtcag tgcttctgac acaacagtct cgaacttaag ctgcagaagt tggtcgtgag      720

gcactgggca ggtaagtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg      780

gcttgtcgag acagagaaga ctcttgcgtt tctgataggc acctattggt cttactgaca      840

tccactttgc ctttctctcc acaggtgtcc actcccagtt caattacagc tcttaaggct      900

agagtactta atacgactca ctataggcta gcctcgacgg taccgcgggc ccgggatccg      960

ccaccatggc ttccaaggtg tacgaccccg agcaacgcaa acgcatgatc actgggcctc     1020

agtggtgggc tcgctgcaag caaatgaacg tgctggactc cttcatcaac tactatgatt     1080

ccgagaagca cgccgagaac gccgtgattt ttctgcatgg taacgctgcc tccagctacc     1140

tgtggaggca cgtcgtgcct cacatcgagc ccgtggctag atgcatcatc cctgatctga     1200

tcggaatggg taagtccggc aagagcggga atggctcata tcgcctcctg gatcactaca     1260

agtacctcac cgcttggttc gagctgctga accttccaaa gaaaatcatc tttgtgggcc     1320

acgactgggg ggcttgtctg gcctttcact actcctacga gcaccaagac aagatcaagg     1380

ccatcgtcca tgctgagagt gtcgtggacg tgatcgagtc ctgggacgag tggcctgaca     1440

tcgaggagga tatcgccctg atcaagagcg aagagggcga gaaaatggtg cttgagaata     1500

acttcttcgt cgagaccatg ctcccaagca agatcatgcg gaaactggag cctgaggagt     1560

tcgctgccta cctggagcca ttcaaggaga agggcgaggt tagacggcct accctctcct     1620

ggcctcgcga gatccctctc gttaagggag gcaagcccga cgtcgtccag attgtccgca     1680

actacaacgc ctaccttcgg gccagcgacg atctgcctaa gatgttcatc gagtccgacc     1740

ctgggttctt ttccaacgct attgtcgagg gagctaagaa gttccctaac accgagttcg     1800

tgaaggtgaa gggcctccac ttcagccagg aggacgctcc agatgaaatg ggtaagtaca     1860

tcaagagctt cgtggagcgc gtgctgaaga acgagcagta atgtacaagt aaagcggccg     1920

cgactctaga tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac     1980

ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg     2040

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     2100

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttaaggc     2160

gggaattgat ctaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     2220

cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct     2280

cagtgagcga gcgagcgcgc agagagggag tggccaaccc cccccccccc cccccggcga     2340

ttctcttgtt tgctccagac tctcaggcaa tgacctgata gcctttgtag agacctctca     2400

aaaatagcta ccctctccgg catgaattta tcagctagaa cggttgaata tcatattgat     2460

ggtgatttga ctgtctccgg cctttctcac ccgtttgaat ctttacctac acattactca     2520

ggcattgcat ttaaaatata tgagggttct aaaaattttt atccttgcgt tgaaataaag     2580

gcttctcccg caaaagtatt acagggtcat aatgtttttg gtacaaccga tttagcttta     2640

tgctctgagg ctttattgct taattttgct aattctttgc cttgcctgta tgatttattg     2700

gatgttggaa tcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     2760

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac     2820

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca     2880

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga     2940

aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa     3000

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt     3060

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa     3120

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta     3180

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag     3240

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca     3300

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     3360

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     3420

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     3480

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     3540

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     3600

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     3660

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     3720

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     3780

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     3840

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     3900

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     3960

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     4020

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     4080

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     4140

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     4200

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     4260

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     4320

atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     4380

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     4440

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     4500

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     4560

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     4620

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     4680

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     4740

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     4800

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     4860

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     4920

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg     4980

cgcgttggcc gattcattaa tgcagctggc gtaatagcga agaggcccgc accgatcgcc     5040

cttcccaaca gttgcgcagc ctgaatggcg aatggcgatt ccgttgcaat ggctggcggt     5100

aatattgttc tggatattac cagcaaggcc gatagtttga gttcttctac tcaggcaagt     5160

gatgttatta ctaatcaaag aagtattgcg acaacggtta atttgcgtga tggacagact     5220

cttttactcg gtggcctcac tgattataaa aacacttctc aggattctgg cgtaccgttc     5280

ctgtctaaaa tccctttaat cggcctcctg tttagctccc gctctgattc taacgaggaa     5340

agcacgttat acgtgctcgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag     5400

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     5460

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     5520

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     5580

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     5640

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     5700

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     5760

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     5820

gcttacaatt taaatatttg cttatacaat cttcctgttt ttggggcttt tctgattatc     5880

aaccggggta catatgattg acatgctagt tttacgatta ccgttcatcg cc             5932


<210> 20
<211> 107
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..107
<223> /mol_type="DNA"
      /note="recognition site for micro RNA 122"
      /organism="Artificial Sequence"

<400> 20
gtaatctaga tcgcgaacaa acaccattgt cacactccag tatacacaaa caccattgtc     60

acactccaga tatcacaaac accattgtca cactccaagg cctggct                  107


<210> 21
<211> 544
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..544
<223> /mol_type="DNA"
      /note="Sequence of the human troponin T promoter"
      /organism="Artificial Sequence"

<400> 21
ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt      60

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag     120

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg     180

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac     240

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat     300

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata     360

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca     420

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc     480

tccatcctct gcctcaccca gtcccaagct ttattgcggt agtttatcac agttaaattg     540

ctaa                                                                  544


<210> 22
<211> 828
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..828
<223> /mol_type="DNA"
      /note="CMVMLC260 Promoter"
      /organism="Artificial Sequence"

<400> 22
gcggccgctt cgagctcgcc cgacattgat tattgactag ttattaatag taatcaatta      60

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg     120

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc     180

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa     240

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca     300

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta     360

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt     420

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg     480

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca     540

actccgcccc atgcggccgc tctaggaccc agagcacaga gcatcgttcc caggccaggc     600

cccagccact gtctctttaa ccttgaaggc atttttgggt ctcacgtgtc cacccaggcg     660

ggtgtcggac tttgaacggc tcttacttca gaagaacggc atggggtggg ggggcttagg     720

tggcctctgc ctcacctaca actgccaaaa gtggtcatgg ggttattttt aaccccaggg     780

aagaggtatt tattgttcca cagcaggggc cggccagcag gctccttg                  828


