                         SEQUENCE LISTING

<110>  SHIVARAMAIAH, Srichaitanya
       HARGIS, Billy
       BARTA, John
       BERGHMAN, Luc
       FAULKNER, Olivia
       BIELKE, Lisa
 
<120>  COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA
        OR LIMITING EIMERIA INFECTION

<130>  5658-00201

<150>  US 61/764,681
<151>  2013-02-14

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: composite minimal epitope


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Arg or Met

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa is Val or Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ser or Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is His or Tyr

<400>  1

Pro Xaa Xaa Xaa Xaa Xaa Gly Tyr Gly Ala Cys Glu Xaa Asn Leu Gly 
1               5                   10                  15      


<210>  2
<211>  43
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(43)
<223>  Eimeria maxima MPP

<400>  2

Pro Ser His Asp Ala Pro Glu Ser Glu Arg Thr Pro Arg Val Ile Ser 
1               5                   10                  15      


Phe Gly Tyr Gly Ala Cys Glu His Asn Leu Gly Val Ser Leu Phe Arg 
            20                  25                  30          


Arg Glu Glu Thr Lys Lys Asp Pro Arg Gly Arg 
        35                  40              


<210>  3
<211>  28
<212>  PRT
<213>  Neospora canium

<400>  3

Pro Arg Ile Val Ser Phe Gly Tyr Gly Ala Cys Glu His Asn Leu Gly 
1               5                   10                  15      


Met Ser Leu Tyr Asp Arg Gln Gly Leu Gln Arg Gln 
            20                  25              


<210>  4
<211>  21
<212>  PRT
<213>  Eimeria tenella

<400>  4

Glu Ser Gln Arg Ala Pro Met Val Ile Arg Tyr Gly Tyr Gly Ala Cys 
1               5                   10                  15      


Glu Tyr Asn Leu Gly 
            20      


<210>  5
<211>  10
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Eimeria maxima TRAP-1

<400>  5

Gly Gly Gly Phe Pro Thr Ala Ala Val Ala 
1               5                   10  


<210>  6
<211>  40
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Eimeria maxima TRAP-02

<400>  6

Ala Ala Pro Glu Thr Pro Ala Val Gln Pro Lys Pro Glu Glu Gly His 
1               5                   10                  15      


Glu Arg Pro Glu Pro Glu Glu Glu Glu Glu Lys Lys Glu Glu Gly Gly 
            20                  25                  30          


Gly Phe Pro Thr Ala Ala Val Ala 
        35                  40  


<210>  7
<211>  40
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Eimeria maxima TRAP-03

<400>  7

Gly Gly Gly Phe Pro Thr Ala Ala Val Ala Gly Gly Val Gly Gly Val 
1               5                   10                  15      


Leu Leu Ile Ala Ala Val Gly Gly Gly Val Ala Ala Phe Thr Ser Gly 
            20                  25                  30          


Gly Gly Gly Ala Gly Ala Gln Glu 
        35                  40  


<210>  8
<211>  70
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(70)
<223>  Eimeria maxima TRAP

<400>  8

Ala Ala Pro Glu Thr Pro Ala Val Gln Pro Lys Pro Glu Glu Gly His 
1               5                   10                  15      


Glu Arg Pro Glu Pro Glu Glu Glu Glu Glu Lys Lys Glu Glu Gly Gly 
            20                  25                  30          


Gly Phe Pro Thr Ala Ala Val Ala Gly Gly Val Gly Gly Val Leu Leu 
        35                  40                  45              


Ile Ala Ala Val Gly Gly Gly Val Ala Ala Phe Thr Ser Gly Gly Gly 
    50                  55                  60                  


Gly Ala Gly Ala Gln Glu 
65                  70  


<210>  9
<211>  8
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Avian Influenza virus m2e

<400>  9

Glu Val Glu Thr Pro Ile Arg Asn 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Avian Influenza virus m2e

<400>  10

Glu Val Glu Thr Pro Thr Arg Asn 
1               5               


<210>  11
<211>  12
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Avian Influenza virus HA5 UA

<400>  11

Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
1               5                   10          


<210>  12
<211>  19
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Avian Influenza virus HA5 LB

<400>  12

Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr 
1               5                   10                  15      


Glu Glu Leu 
            


<210>  13
<211>  16
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Avian Influenza virus NP 54-69

<400>  13

Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu Arg Met Val Leu Ser 
1               5                   10                  15      


<210>  14
<211>  14
<212>  PRT
<213>  Avian Influenza


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  Avian Influenza virus NP 147-160

<400>  14

Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
1               5                   10                  


<210>  15
<211>  190
<212>  PRT
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (1)..(190)
<223>  Chicken HMGB1 amino acid

<400>  15

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ser Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Leu Arg Tyr Glu Lys Glu Met Lys Asn Tyr Val Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Val Asp Ala Gly Lys Lys Val Val Ala 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp 
            180                 185                 190 


<210>  16
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 box a1

<400>  16

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ser Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Leu Arg Tyr Glu Lys Glu Met Lys Asn Tyr Val Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr 
                85  


<210>  17
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 box a2

<400>  17

Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu 
1               5                   10                  15      


Arg Trp Lys Thr Met Ser Ser Lys Glu Lys Gly Lys Phe Glu Asp Met 
            20                  25                  30          


Ala Lys Ala Asp Lys Leu Arg Tyr Glu Lys Glu Met Lys Asn Tyr Val 
        35                  40                  45              


Pro Pro Lys Gly Glu Thr 
    50                  


<210>  18
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 box b1

<400>  18

Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe 
1               5                   10                  15      


Cys Ser Glu Phe Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser 
            20                  25                  30          


Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala 
        35                  40                  45              


Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu 
    50                  55                  60                  


Lys Tyr Glu Lys Asp Ile Ala Ala Tyr 
65                  70              


<210>  19
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 box b2

<400>  19

Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu 
1               5                   10                  15      


Phe Arg Pro Lys Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp 
            20                  25                  30          


Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp 
        35                  40                  45              


Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu 
    50                  55                  60                  


Lys Asp Ile Ala Ala 
65                  


<210>  20
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 RAGE Binding domain

<400>  20

Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe Leu Phe 
1               5                   10                  15      


Cys Ser Glu Phe Arg 
            20      


<210>  21
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: HMGB1 proinflammatory cytokine activity

<400>  21

Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly 
1               5                   10                  15      


Lys Val Asp Ala Gly Lys Lys Val Val Ala Lys Ala Glu Lys Ser Lys 
            20                  25                  30          


Lys 
    


<210>  22
<211>  215
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(215)
<223>  HMGB1

<400>  22

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


<210>  23
<211>  205
<212>  PRT
<213>  Danio rerio


<220>
<221>  misc_feature
<222>  (1)..(205)
<223>  Zebra fish HMGB1

<400>  23

Met Gly Lys Asp Pro Thr Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
1               5                   10                  15      


Tyr Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Glu 
            20                  25                  30          


Ala Thr Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
        35                  40                  45              


Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
    50                  55                  60                  


Leu Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Asn Tyr Ile Pro Pro 
65                  70                  75                  80  


Lys Gly Glu Lys Lys Lys Arg Phe Lys Asp Pro Asn Ala Pro Lys Arg 
                85                  90                  95      


Pro Pro Ser Ala Phe Phe Ile Phe Cys Ser Glu Phe Arg Pro Lys Val 
            100                 105                 110         


Lys Glu Glu Thr Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Arg Leu 
        115                 120                 125             


Gly Glu Met Trp Asn Lys Ile Ser Ser Glu Glu Lys Gln Pro Tyr Glu 
    130                 135                 140                 


Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala 
145                 150                 155                 160 


Tyr Arg Ser Lys Gly Lys Val Gly Gly Gly Ala Ala Lys Ala Pro Ser 
                165                 170                 175     


Lys Pro Asp Lys Ala Asn Asp Glu Asp Glu Asp Asp Asp Glu Glu Glu 
            180                 185                 190         


Asp Glu Asp Asp Asp Asp Glu Glu Glu Glu Asp Asp Glu 
        195                 200                 205 


<210>  24
<211>  272
<212>  PRT
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (1)..(272)
<223>  CD154 chicken

<400>  24

Met Asn Glu Ala Tyr Ser Pro Ala Ala Pro Arg Pro Met Gly Ser Thr 
1               5                   10                  15      


Ser Pro Ser Thr Met Lys Met Phe Met Cys Phe Leu Ser Val Phe Met 
            20                  25                  30          


Val Val Gln Thr Ile Gly Thr Val Leu Phe Cys Leu Tyr Leu His Met 
        35                  40                  45              


Lys Met Asp Lys Met Glu Glu Val Leu Ser Leu Asn Glu Asp Tyr Ile 
    50                  55                  60                  


Phe Leu Arg Lys Val Gln Lys Cys Gln Thr Gly Glu Asp Gln Lys Ser 
65                  70                  75                  80  


Thr Leu Leu Asp Cys Glu Lys Val Leu Lys Gly Phe Gln Asp Leu Gln 
                85                  90                  95      


Cys Lys Asp Arg Thr Ala Ser Glu Glu Leu Pro Lys Phe Glu Met His 
            100                 105                 110         


Arg Gly His Glu His Pro His Leu Lys Ser Arg Asn Glu Thr Ser Val 
        115                 120                 125             


Ala Glu Glu Lys Arg Gln Pro Ile Ala Thr His Leu Ala Gly Val Lys 
    130                 135                 140                 


Ser Asn Thr Thr Val Arg Val Leu Lys Trp Met Thr Thr Ser Tyr Ala 
145                 150                 155                 160 


Pro Thr Ser Ser Leu Ile Ser Tyr His Glu Gly Lys Leu Lys Val Glu 
                165                 170                 175     


Lys Ala Gly Leu Tyr Tyr Ile Tyr Ser Gln Val Ser Phe Cys Thr Lys 
            180                 185                 190         


Ala Ala Ala Ser Ala Pro Phe Thr Leu Tyr Ile Tyr Leu Tyr Leu Pro 
        195                 200                 205             


Met Glu Glu Asp Arg Leu Leu Met Lys Gly Leu Asp Thr His Ser Thr 
    210                 215                 220                 


Ser Thr Ala Leu Cys Glu Leu Gln Ser Ile Arg Glu Gly Gly Val Phe 
225                 230                 235                 240 


Glu Leu Arg Gln Gly Asp Met Val Phe Val Asn Val Thr Asp Ser Thr 
                245                 250                 255     


Ala Val Asn Val Asn Pro Gly Asn Thr Tyr Phe Gly Met Phe Lys Leu 
            260                 265                 270         


<210>  25
<211>  261
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(261)
<223>  Human CD154

<400>  25

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Human CD154 peptide

<400>  26

Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Cys 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Gallus gallus


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Chicken CD154 peptide

<400>  27

Trp Met Thr Thr Ser Tyr Ala Pro Thr Ser Ser 
1               5                   10      


<210>  28
<211>  10
<212>  PRT
<213>  Anas sp.


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Duck CD154 peptide

<400>  28

Trp Asn Lys Thr Ser Tyr Ala Pro Met Asn 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Mus sp.


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Mouse CD154 peptide

<400>  29

Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Bos taurus


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Cow CD154 peptide

<400>  30

Trp Ala Pro Lys Gly Tyr Tyr Thr Leu Ser 
1               5                   10  


<210>  31
<211>  918
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic: TRAP MPP HMGB1 nucleotide sequence

<400>  31
ggatccatgg gcggtagcag cagaagcagc gcagcacctg aaacgagagc agtccagccg       60

aaacctgaag aaggccatga aagacctgaa cctgaagaag aagaagagaa aaaagaagaa      120

ggcggcggct ttcctacagc agcagtcgcg ggcggatcaa gcagatcttc cccttctcat      180

gatgcgcctg aaagcgaacg gacgcctcgg gttatctcct ttggttacgg tgcgtgcgaa      240

cataatctgg gcgtctctct ttttagacgc gaagaaacga aaaaagatcc gcgtggacgg      300

ggcggatcaa gcagatcttc catgggtaaa ggcgacccga aaaaacctcg gggcaaaatg      360

tcaagctacg catttttcgt ccaaacatgc agagaagaac ataagaaaaa acatcctgat      420

gctagcgtaa acttttcaga atttagcaaa aaatgttctg aacgttggaa aacgatgtct      480

tccaaagaaa agggtaaatt tgaagatatg gctaaagccg acaaattgcg gtacgaaaaa      540

gaaatgaaaa actacgtacc gcctaaagga gaaacaaaga aaaaatttaa agatccgaac      600

gcccctaaaa gaccgccttc tgcatttttc ctgttttgct ccgaatttcg cccgaaaatt      660

aaaggagaac atcctggtct gagcatcggc gacgttgcga aaaaacttgg agaaatgtgg      720

aataacacgg cagcggatga caaacagccg tatgagaaaa aagctgccaa attgaaagaa      780

aaatacgaaa aagatatcgc agcgtaccgc gcaaaaggaa aagtggacgc gggtaaaaaa      840

gttgtggcta aagcggaaaa atcaaagaag aaaaaggaag aagaagaaga cggcggctca      900

tctcggtcct ccgacgtc                                                    918


<210>  32
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: TRAP MPP HMGB1 peptide

<400>  32

Gly Ser Met Gly Gly Ser Ser Arg Ser Ser Ala Ala Pro Glu Thr Arg 
1               5                   10                  15      


Ala Val Gln Pro Lys Pro Glu Glu Gly His Glu Arg Pro Glu Pro Glu 
            20                  25                  30          


Glu Glu Glu Glu Lys Lys Glu Glu Gly Gly Gly Phe Pro Thr Ala Ala 
        35                  40                  45              


Val Ala Gly Gly Ser Ser Arg Ser Ser Pro Ser His Asp Ala Pro Glu 
    50                  55                  60                  


Ser Glu Arg Thr Pro Arg Val Ile Ser Phe Gly Tyr Gly Ala Cys Glu 
65                  70                  75                  80  


His Asn Leu Gly Val Ser Leu Phe Arg Arg Glu Glu Thr Lys Lys Asp 
                85                  90                  95      


Pro Arg Gly Arg Gly Gly Ser Ser Arg Ser Ser Met Gly Lys Gly Asp 
            100                 105                 110         


Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala Phe Phe Val Gln 
        115                 120                 125             


Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp Ala Ser Val Asn 
    130                 135                 140                 


Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser 
145                 150                 155                 160 


Ser Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Leu 
                165                 170                 175     


Arg Tyr Glu Lys Glu Met Lys Asn Tyr Val Pro Pro Lys Gly Glu Thr 
            180                 185                 190         


Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala 
        195                 200                 205             


Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys Gly Glu His 
    210                 215                 220                 


Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp 
225                 230                 235                 240 


Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala Ala 
                245                 250                 255     


Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys 
            260                 265                 270         


Gly Lys Val Asp Ala Gly Lys Lys Val Val Ala Lys Ala Glu Lys Ser 
        275                 280                 285             


Lys Lys Lys Lys Glu Glu Glu Glu Asp Gly Gly Ser Ser Arg Ser Ser 
    290                 295                 300                 


Asp Val 
305     


<210>  33
<211>  777
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic: MPP HMGB1 nucleotide

<400>  33
ggatccatgg gcggtagcag cagaagcagc ccttctcatg atgcgcctga aagcgaacgg       60

acgcctcggg ttatctcctt tggttacggt gcgtgcgaac ataatctggg cgtctctctt      120

tttagacgcg aagaaacgaa aaaagatccg cgtggacggg gcggatcaag cagatcttcc      180

atgggtaaag gcgacccgaa aaaacctcgg ggcaaaatgt caagctacgc atttttcgtc      240

caaacatgca gagaagaaca taagaaaaaa catcctgatg ctagcgtaaa cttttcagaa      300

tttagcaaaa aatgttctga acgttggaaa acgatgtctt ccaaagaaaa gggtaaattt      360

gaagatatgg ctaaagccga caaattgcgg tacgaaaaag aaatgaaaaa ctacgtaccg      420

cctaaaggag aaacaaagaa aaaatttaaa gatccgaacg cccctaaaag accgccttct      480

gcatttttcc tgttttgctc cgaatttcgc ccgaaaatta aaggagaaca tcctggtctg      540

agcatcggcg acgttgcgaa aaaacttgga gaaatgtgga ataacacggc agcggatgac      600

aaacagccgt atgagaaaaa agctgccaaa ttgaaagaaa aatacgaaaa agatatcgca      660

gcgtaccgcg caaaaggaaa agtggacgcg ggtaaaaaag ttgtggctaa agcggaaaaa      720

tcaaagaaga aaaaggaaga agaagaagac ggcggctcat ctcggtcctc cgacgtc         777


<210>  34
<211>  259
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: MPP HMGB1 peptide

<400>  34

Gly Ser Met Gly Gly Ser Ser Arg Ser Ser Pro Ser His Asp Ala Pro 
1               5                   10                  15      


Glu Ser Glu Arg Thr Pro Arg Val Ile Ser Phe Gly Tyr Gly Ala Cys 
            20                  25                  30          


Glu His Asn Leu Gly Val Ser Leu Phe Arg Arg Glu Glu Thr Lys Lys 
        35                  40                  45              


Asp Pro Arg Gly Arg Gly Gly Ser Ser Arg Ser Ser Met Gly Lys Gly 
    50                  55                  60                  


Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala Phe Phe Val 
65                  70                  75                  80  


Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp Ala Ser Val 
                85                  90                  95      


Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met 
            100                 105                 110         


Ser Ser Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys 
        115                 120                 125             


Leu Arg Tyr Glu Lys Glu Met Lys Asn Tyr Val Pro Pro Lys Gly Glu 
    130                 135                 140                 


Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser 
145                 150                 155                 160 


Ala Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys Gly Glu 
                165                 170                 175     


His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met 
            180                 185                 190         


Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala 
        195                 200                 205             


Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala 
    210                 215                 220                 


Lys Gly Lys Val Asp Ala Gly Lys Lys Val Val Ala Lys Ala Glu Lys 
225                 230                 235                 240 


Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Gly Gly Ser Ser Arg Ser 
                245                 250                 255     


Ser Asp Val 
            


<210>  35
<211>  768
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic: TRAP HMGB1 nucleotide sequence

<400>  35
ggatccatgg gcggtagcag cagaagcagc gcagcacctg aaacgagagc agtccagccg       60

aaacctgaag aaggccatga aagacctgaa cctgaagaag aagaagagaa aaaagaagaa      120

ggcggcggct ttcctacagc agcagtcgcg ggcggatcaa gcagatcttc catgggtaaa      180

ggcgacccga aaaaacctcg gggcaaaatg tcaagctacg catttttcgt ccaaacatgc      240

agagaagaac ataagaaaaa acatcctgat gctagcgtaa acttttcaga atttagcaaa      300

aaatgttctg aacgttggaa aacgatgtct tccaaagaaa agggtaaatt tgaagatatg      360

gctaaagccg acaaattgcg gtacgaaaaa gaaatgaaaa actacgtacc gcctaaagga      420

gaaacaaaga aaaaatttaa agatccgaac gcccctaaaa gaccgccttc tgcatttttc      480

ctgttttgct ccgaatttcg cccgaaaatt aaaggagaac atcctggtct gagcatcggc      540

gacgttgcga aaaaacttgg agaaatgtgg aataacacgg cagcggatga caaacagccg      600

tatgagaaaa aagctgccaa attgaaagaa aaatacgaaa aagatatcgc agcgtaccgc      660

gcaaaaggaa aagtggacgc gggtaaaaaa gttgtggcta aagcggaaaa atcaaagaag      720

aaaaaggaag aagaagaaga cggcggctca tctcggtcct ccgacgtc                   768


<210>  36
<211>  256
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: TRAP HMGB1 peptide

<400>  36

Gly Ser Met Gly Gly Ser Ser Arg Ser Ser Ala Ala Pro Glu Thr Arg 
1               5                   10                  15      


Ala Val Gln Pro Lys Pro Glu Glu Gly His Glu Arg Pro Glu Pro Glu 
            20                  25                  30          


Glu Glu Glu Glu Lys Lys Glu Glu Gly Gly Gly Phe Pro Thr Ala Ala 
        35                  40                  45              


Val Ala Gly Gly Ser Ser Arg Ser Ser Met Gly Lys Gly Asp Pro Lys 
    50                  55                  60                  


Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala Phe Phe Val Gln Thr Cys 
65                  70                  75                  80  


Arg Glu Glu His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser 
                85                  90                  95      


Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp Lys Thr Met Ser Ser Lys 
            100                 105                 110         


Glu Lys Gly Lys Phe Glu Asp Met Ala Lys Ala Asp Lys Leu Arg Tyr 
        115                 120                 125             


Glu Lys Glu Met Lys Asn Tyr Val Pro Pro Lys Gly Glu Thr Lys Lys 
    130                 135                 140                 


Lys Phe Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Ala Phe Phe 
145                 150                 155                 160 


Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys Gly Glu His Pro Gly 
                165                 170                 175     


Leu Ser Ile Gly Asp Val Ala Lys Lys Leu Gly Glu Met Trp Asn Asn 
            180                 185                 190         


Thr Ala Ala Asp Asp Lys Gln Pro Tyr Glu Lys Lys Ala Ala Lys Leu 
        195                 200                 205             


Lys Glu Lys Tyr Glu Lys Asp Ile Ala Ala Tyr Arg Ala Lys Gly Lys 
    210                 215                 220                 


Val Asp Ala Gly Lys Lys Val Val Ala Lys Ala Glu Lys Ser Lys Lys 
225                 230                 235                 240 


Lys Lys Glu Glu Glu Glu Asp Gly Gly Ser Ser Arg Ser Ser Asp Val 
                245                 250                 255     


<210>  37
<211>  32
<212>  PRT
<213>  Toxoplasma gondii


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Toxoplasma gondii RH

<400>  37

Pro Arg Val Ile Ser Phe Gly Tyr Gly Ala Cys Glu His Asn Leu Gly 
1               5                   10                  15      


Val Ser Leu Phe Arg Arg Glu Glu Thr Lys Lys Asp Pro Arg Gly Arg 
            20                  25                  30          


<210>  38
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: Consensus sequence


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (35)..(39)
<223>  Xaa can be any amino acid

<400>  38

Pro Ser His Asp Ala Pro Glu Ser Glx Arg Xaa Pro Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Tyr Gly Ala Cys Glu Xaa Asn Leu Gly Xaa Ser Leu Xaa Xaa 
            20                  25                  30          


Arg Glx Xaa Xaa Xaa Xaa Xaa Pro Arg Gly Arg 
        35                  40              


<210>  39
<211>  841
<212>  PRT
<213>  Toxoplasma gondii


<220>
<221>  misc_feature
<222>  (1)..(841)
<223>  Toxoplasma gondii ROM5

<400>  39

Met Ser Ser Lys Gly Gly Ser Ser Arg Leu Gly Ser Lys Asp Leu Lys 
1               5                   10                  15      


Lys Met Thr Ser Arg Thr Glu Arg Glu Leu Arg Asp Ser Gly Arg Val 
            20                  25                  30          


Arg Gly Glu Val Glu Arg Val Glu Lys Arg Leu Arg Ala Thr Ala Lys 
        35                  40                  45              


Val Lys Glu Gln Pro Pro Thr Gly Asp Tyr Lys Arg Arg Ala Leu Ala 
    50                  55                  60                  


Ser Pro Gly Glu Thr Ala Ala Pro Thr Phe Leu Val Asp Ser Arg Gly 
65                  70                  75                  80  


Ile Pro Arg Lys Thr Ser Ser Thr Ala Pro Arg Lys Ala Thr Leu Arg 
                85                  90                  95      


Pro Ala Ser Ser Ser Pro Arg Leu Ala Ser Ser Ser Arg Pro Thr Glu 
            100                 105                 110         


Ser Thr Leu Pro Ser Ser Ser Ser Arg Ala Leu Gln Gly Ala Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Arg Pro Arg Arg Leu His Glu Ser Ala Ser Gly Arg 
    130                 135                 140                 


Gly Gly Ser Gly Gly Ser Ala Gly Glu Leu Arg Gln Glu Lys Lys Arg 
145                 150                 155                 160 


Leu Pro Glu Leu Glu Ala Ala Glu Ala Ala Pro Ala Ser Cys Val Val 
                165                 170                 175     


Glu Leu Arg Asp Val Thr Ala Arg Lys Gly Arg Thr Ser Pro Ala Thr 
            180                 185                 190         


Pro Pro Glu Thr Ala Gly Ser Ser Val Cys Gly Gln Gly Ser His Ala 
        195                 200                 205             


Arg Thr Ala Glu Lys Leu Glu Glu Gly Thr Ala Ser His Arg Asp Gly 
    210                 215                 220                 


Ser Arg Arg Gly Ser Val Asp Ala Glu Thr Trp Ala Thr Pro Gly Asp 
225                 230                 235                 240 


Gly Ser Ser Ser His Glu Phe Glu Ser Ser Pro Gln Arg Glu Glu Arg 
                245                 250                 255     


Met Gln Pro Gln Glu Thr Gly Arg Arg Glu Leu Ser Ser Glu Pro Arg 
            260                 265                 270         


Ser Gly Asp Leu Thr Lys Asn Gly Gly Asp Gly Gly Pro Arg Arg His 
        275                 280                 285             


Ser Cys Ala Trp Arg Lys Trp Arg Glu His Met Ile Gln Ser Phe Asp 
    290                 295                 300                 


Ile Thr Thr His Pro Phe Pro Pro Arg Gly Asp Gly Ser Pro Arg Arg 
305                 310                 315                 320 


Gly Lys Phe Leu Met Ile Phe Leu Thr Ser Ser Val Leu Phe Phe Val 
                325                 330                 335     


Phe Leu Gln Glu Leu Val Leu Asn Val Thr Thr Phe Asn Gly Arg Cys 
            340                 345                 350         


Met Ser Pro Val Leu Tyr Pro Ser His Asp Ala Pro Glu Ser Glu Arg 
        355                 360                 365             


Thr Pro Arg Val Ile Ser Phe Gly Tyr Gly Ala Cys Glu His Asn Leu 
    370                 375                 380                 


Gly Val Ser Leu Phe Arg Arg Glu Glu Thr Lys Lys Asp Pro Arg Gly 
385                 390                 395                 400 


Arg Trp Thr Pro Gly Pro Leu Thr Glu Arg Cys Ala Ser Gly Arg Cys 
                405                 410                 415     


Ala Ser Asp Asp Gly Trp Pro Ser Asp Leu Val Gln Arg Gly Arg Ala 
            420                 425                 430         


Gln Arg Ser Pro Ala Ala Phe Asp Ser Pro Asn Pro Arg Val Phe Ser 
        435                 440                 445             


Ser Leu Gly Ala Leu Asp Thr Asn Lys Val Arg Asn Tyr Gly Glu Met 
    450                 455                 460                 


Phe Arg Val Val Trp Gly Met Phe Leu His Gly Gly Trp Met His Leu 
465                 470                 475                 480 


Leu Leu Asn Val Ser Cys Gln Ala Gln Thr Leu Trp Ile Leu Glu Pro 
                485                 490                 495     


Ala Trp Gly Phe Leu Arg Thr Leu Ser Leu Trp Ile Val Gly Gly Val 
            500                 505                 510         


Ser Gly Ser Leu Leu Ser Ala Val Ala Asn Pro Cys Thr Val Thr Val 
        515                 520                 525             


Gly Ser Ser Gly Ala Phe Tyr Gly Leu Leu Gly Ala Leu Val Pro Phe 
    530                 535                 540                 


Ser Ile Glu Tyr Trp Asp His Ile Ala Ser Pro Ala Trp Phe Leu Phe 
545                 550                 555                 560 


Cys Val Ser Val Leu Val Met Val Ala Gln Phe Gly Asn Met Val Gly 
                565                 570                 575     


Val Gln Gly Val Asp Asn Asn Ala His Leu Gly Gly Leu Ile Gly Gly 
            580                 585                 590         


Leu Leu Phe Gly Phe Ala Thr Ile Arg Ser Val His Ala Phe Arg Trp 
        595                 600                 605             


Gln Gly Val Ala Glu Arg Met Ala Ser Ser Thr Leu Phe Trp Trp Met 
    610                 615                 620                 


Phe Pro Ala Glu Lys Arg Arg Ser Leu Arg Glu Asp Asn Leu Gln Arg 
625                 630                 635                 640 


Val Ala Arg Glu Arg Glu Glu Arg Ser Ser Gly Arg Ile Pro Pro Pro 
                645                 650                 655     


Lys Phe Val Trp Lys Phe Arg Gly His Glu Arg Glu Trp Cys Val Arg 
            660                 665                 670         


Phe Ala Ala Ala Val Gly Leu Val Thr Phe Trp Ser Val Leu Trp Leu 
        675                 680                 685             


Tyr Leu Leu Val Pro Ser Tyr Tyr Glu Ser Leu Ser Ser Pro Pro Gly 
    690                 695                 700                 


Asn Phe Ser Phe Leu Gly Ser Thr Gly Cys His Cys Cys Arg Val Gln 
705                 710                 715                 720 


Pro Phe Pro Gly Glu Glu Asp Lys Leu Pro Ala Phe His Pro Val Arg 
                725                 730                 735     


Val Asn Arg Gly Leu Phe Trp Cys Phe Val Ser Glu Gly Val Ala Asn 
            740                 745                 750         


Leu Phe Cys Gly Arg Ser Ser Ala Leu Asn Arg Gly Ala Asp Val Tyr 
        755                 760                 765             


Gly Gln Thr Arg Gln Phe Glu Glu Ala Leu Gly Asp Leu Pro Ser Ala 
    770                 775                 780                 


Arg Ala Gly Glu Ala Pro Leu Arg Ile Ala Lys Glu Glu Gly Glu Ser 
785                 790                 795                 800 


Ala Ser Val Trp Gln Arg Leu Val Lys Ser Ala Lys Lys Thr Tyr Asn 
                805                 810                 815     


Ala Val Leu Gly Asn Thr Thr Thr Pro Ala Ala Pro Ser Ala Ala Glu 
            820                 825                 830         


Leu Ala Gln Gln Thr Arg Ala Gly Gln 
        835                 840     


<210>  40
<211>  40
<212>  PRT
<213>  Eimeria maxima


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Eimeria maxima TRAP-02A

<400>  40

Ala Ala Pro Glu Thr Arg Ala Val Gln Pro Lys Pro Glu Glu Gly His 
1               5                   10                  15      


Glu Arg Pro Glu Pro Glu Glu Glu Glu Glu Lys Lys Glu Glu Gly Gly 
            20                  25                  30          


Gly Phe Pro Thr Ala Ala Val Ala 
        35                  40  


