                         SEQUENCE LISTING

<110>  ESBATech - a Novartis Company LLC
 
<120>  ACCEPTOR FRAMEWORK FOR CDR GRAFTING

<130>  PCT86604FZ210pau

<140>  not yet assigned
<141>  2013-02-20

<160>  7     

<170>  PatentIn version 3.4

<210>  1
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  variable heavy chain framework a72


<220>
<221>  MISC_FEATURE
<222>  (26)..(75)
<223>  CDR1; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(139)
<223>  CDR2; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (172)..(221)
<223>  CDR3; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Gly Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln His 
65                  70                  75                  80  


Pro Val Lys Gly Leu Glu Trp Ile Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Leu Thr Ile Ser 
    130                 135                 140                 


Val Asp Thr Ser Lys Thr Gln Val Ser Leu Asn Leu Arg Ser Val Thr 
145                 150                 155                 160 


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln 
    210                 215                 220                 


Gly Thr Thr Val Thr Val Ser Ser 
225                 230         


<210>  2
<211>  231
<212>  PRT
<213>  Artificial

<220>
<223>  variable light chain framework KI27


<220>
<221>  MISC_FEATURE
<222>  (24)..(73)
<223>  CDR1; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (89)..(138)
<223>  CDR2; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (171)..(220)
<223>  CDR3; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<400>  2

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly 
65                  70                  75                  80  


Lys Ala Pro Lys Leu Leu Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Val Pro Ser Arg Phe 
    130                 135                 140                 


Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu 
145                 150                 155                 160 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Thr Val Leu Gly 
225                 230     


<210>  3
<211>  483
<212>  PRT
<213>  Artificial

<220>
<223>  framework sequence


<220>
<221>  MISC_FEATURE
<222>  (24)..(73)
<223>  CDR1; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (89)..(138)
<223>  CDR2; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (171)..(220)
<223>  CDR3; at least 3 and up to 50 amino acids can be present or 
       absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (277)..(326)
<223>  Heavy Chain CDR1; at least 3 and up to 50 amino acids can be 
       present or absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (341)..(390)
<223>  Heavy Chain CDR2; at least 3 and up to 50 amino acids can be 
       present or absent; Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (423)..(472)
<223>  Heavy Chain CDR3; at least 3 and up to 50 amino acids can be 
       present or absent; Xaa can be any naturally occurring amino acid

<400>  3

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly 
65                  70                  75                  80  


Lys Ala Pro Lys Leu Leu Ile Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Val Pro Ser Arg Phe 
    130                 135                 140                 


Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu 
145                 150                 155                 160 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr 
            260                 265                 270         


Cys Gly Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Trp Ile Arg Gln His Pro Val Lys Gly Leu 
                325                 330                 335     


Glu Trp Ile Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Arg Leu Thr Ile Ser Val Asp Thr Ser Lys 
385                 390                 395                 400 


Thr Gln Val Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala 
                405                 410                 415     


Val Tyr Tyr Cys Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Thr Val Thr 
465                 470                 475                 480 


Val Ser Ser 
            


<210>  4
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  6

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
1               5                   10      


<210>  7
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  linker sequence

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ala Ser 
            20                  25  


